1. Developing a novel patient reported outcomes measure for prostate cancer patients receiving radionuclide therapy
- Author
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Gudenkauf, Lisa M, Chavez, Melody N, Maconi, Melinda Leigh, Geiss, Carley, Seyedroudbari, Ameen, Thin, Pan, Hoogland, Aasha I, Nguyen, Kathleen, Murthy, Vishnu, Armstrong, Wesley R, Komrokji, Khaled, Oswald, Laura B, Jim, Heather SL, El-Haddad, Ghassan, Fendler, Wolfgang P, Herrmann, Ken, Cella, David, Czernin, Johannes, Hofman, Michael S, Dicker, Adam P, Calais, Jeremie, Tagawa, Scott T, and Gonzalez, Brian D
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Prostate Cancer ,Urologic Diseases ,Good Health and Well Being ,Male ,Humans ,Prostatic Neoplasms ,Radioisotopes ,Patient Reported Outcome Measures ,genitourinary oncology ,radionuclide therapy ,radiophar ,maceuticals ,patient -reported outcomes ,prostate cancer ,radionu ,clide therapy ,patient-reported outcomes ,radiopharmaceuticals ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
The field of radionuclide therapy (RNT) for prostate cancer (PC) is growing rapidly, with recent Food and Drug Administration approval of the first 177Lu-PSMA ligand. We aimed to develop the first patient-reported outcome (PRO) measure for PC patients receiving RNT. Methods: We identified relevant symptoms and toxicities by reviewing published trials and interviews with PC patients receiving RNT (n = 29), caregivers (n = 14), and clinicians (n = 11). Second, we selected items for measure inclusion. Third, we refined the item list with input from experts in RNTs and PROs. Fourth, we finalized the Functional Assessment of Cancer Therapy-Radionuclide Therapy (FACT-RNT) with patient input. Results: This multistep process yielded a brief 15-item measure deemed by key stakeholders to be relevant and useful in the context of RNT for PC. Conclusion: The FACT-RNT is a new standardized tool to monitor relevant symptoms and toxicities among PC patients in RNT trials and real-world settings.
- Published
- 2023