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1. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases

Author

Yousif, Zaid K, Koola, Jejo D, Macedo, Etienne, Cerda, Jorge, Goldstein, Stuart L, Chakravarthi, Rajasekara, Lewington, Andrew, Selewski, David, Zappitelli, Michael, Cruz, Dinna, Tolwani, Ashita, Joy, Melanie S, Jha, Vivekanand, Ramachandran, Raja, Ostermann, Marlies, Yang, Li, Pandya, Bhavna, Acharya, Anjali, Brophy, Patrick, Ponce, Daniela, Steinke, Julia, Bouchard, Josee, Irarrazabal, Carlos E, Irarrazabal, Romina, Boltansky, Andrés, Askenazi, David, Kolhe, Nitin, Granado, Rolando Claure-Del, Benador, Nadine, Castledine, Clare, Davenport, Andrew, Barratt, Jonathan, Bhandari, Sunil, Riley, Alyssa A, Akcan-Arikan, Ayse, Davis, TK, Farmer, Christopher, Hogarth, Michael, Thomas, Mark, Murray, Patrick T, Robinson-Cohen, Cassianne, Nicoletti, Paola, Vaingankar, Sucheta, Mehta, Ravindra, and Awdishu, Linda

Subjects
Kidney Disease, Patient Safety, Renal and urogenital, Good Health and Well Being
Published
2023

2. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases

Author

Yousif, Zaid K., Koola, Jejo D., Macedo, Etienne, Cerda, Jorge, Goldstein, Stuart L., Chakravarthi, Rajasekara, Lewington, Andrew, Selewski, David, Zappitelli, Michael, Cruz, Dinna, Tolwani, Ashita, Joy, Melanie S., Jha, Vivekanand, Ramachandran, Raja, Ostermann, Marlies, Pandya, Bhavna, Acharya, Anjali, Brophy, Patrick, Ponce, Daniela, Steinke, Julia, Bouchard, Josee, Irarrazabal, Carlos E., Irarrazabal, Romina, Boltansky, Andrés, Askenazi, David, Kolhe, Nitin, Claure-Del Granado, Rolando, Benador, Nadine, Castledine, Clare, Davenport, Andrew, Barratt, Jonathan, Bhandari, Sunil, Riley, Alyssa A., Davis, T.K., Farmer, Christopher, Hogarth, Michael, Thomas, Mark, Murray, Patrick T., Robinson-Cohen, Cassianne, Nicoletti, Paola, Vaingankar, Sucheta, Mehta, Ravindra, and Awdishu, Linda

Published
2023
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3. Variation in renal service provision in the UK

Author

Castledine, Clare

Subjects
362.1966
Abstract

Introduction: There is variation in both the incidence of renal replacement therapy (RRT) and the proportion of patients using home as opposed to hospital based treatments for their renal disease. The determinants of this variation have not been fully elucidated and this work seeks to explain this variation by looking at socio-demographic, health status, access to healthcare and renal centre practice pattern factors. Methods: The determinants of RRT incidence were examined using an ecological approach. Multilevel Poisson regression models using local health' area rate of RRT incidence per year as the outcome variable were constructed. Publically available information about the socio-demographic, health status and healthcare access of each local health area were then included in these models as explanatory variables. A national renal centre survey was purposely designed to determine the practice patterns in use in each renal centre. The contents of this survey were determined by using a two stage modified Delphi consensus generating process with a group of renal stakeholders. The survey results were then added to these models to further explain variation in RRT incidence. The determinants of home dialysis uptake were examined using individual patient level logistic regression models with the percentage of patients using home dialysis in that centre as the outcome variable and individual patient characteristics as the explanatory variables. The survey responses were then added to these models to further explain variation. Results: Population socio-demographic, health status and access to healthcare markers were all associated with RRT incidence. Renal centre capacity, rates of treatment in older persons, use of variable price contracts with private dialysis companies and the number of out-patient appointments provided were all practice patterns associated with RRT incidence. Age, distance lived from a renal unit, socio-economic deprivation score, ethnic group and primary renal disease were all associated with use of home dialysis. There were higher rates of home dialysis in centres with physician enthusiasm for the modality, home visits for education, home visits for troubleshooting problems once on home therapy and centres with a responsive access service.

Published
2013

9. UK Renal Registry 20th Annual Report:Chapter 1 UK Renal Replacement Therapy Adult Incidence in 2016: National and Centre-specific Analyses

Author

Hole, Barnaby, Gilg, Julie, Casula, Anna, Methven, Shona, and Castledine, Clare

Subjects
Transplantation, Acute haemodialysis, Renal replacement therapy, Incidence, Diabetes, Peritoneal dialysis, Incidence rates, Comorbidity, urologic and male genital diseases, End stage renal disease, Haemodialysis, Glomerulonephritis, End stage renal failure, Registries, Established renal failure, Treatment modality, Dialysis
Abstract

The incidence rate in the UK decreased from 120 per million population (pmp) in 2015 to 118 pmp in 2016 reflecting renal replacement therapy (RRT) initiation for 7,759 new patients. The median age of all incident patients was 64.3 years, but this was highly dependent on ethnicity (66.2 years for White incident patients, 58.7 years for non-White patients). Diabetic renal disease remained the single most common cause of renal failure treated by RRT (28.6%). By 90 days, 66.6% of patients were on haemodialysis (HD), 19.6% on peritoneal dialysis (PD), 9.3% had a functioning transplant (Tx) and 4.6% had died or stopped treatment. The percentage of RRT patients at 90 days who had a functioning transplant varied between centres from 0% to 31% (between 2% and 31% for transplanting centres and between 0% and 19% for non-transplanting centres). The mean EGFR at the start of RRT was 7.4 ml/min/1.73 m2 by the CKD-EPI method and 8.5 ml/min/1.73 m2 by the MDRD method, similar to the previous five years. Late presentation continued to fall from 23.9% in 2006 to 15.6% in 2016. Timeline codes indicated that 6,891 first-ever HD sessions were delivered in 2016 across 62 centres in England, Wales and Northern Ireland. Of these, 2,581 (37.5%) were classified as acute HD and the remaining 4,310 (62.5%) as HD for established renal failure (ERF). Data relating to the first HD session were available for 5,373 (78.0%) HD starts. After centre exclusions, 4,191 (79.7%) of 5,257 timeline and sessional HD start dates were on the same day and 97.2% were within two weeks of each other. These low levels of discordance are unlikely to meaningfully influence overall survival data for HD recipients. Of the 2,581 individuals who received acute HD, 790 (30.6%) developed ERF and 1,791 (69.4%) died, stopped RRT or recovered renal function. It is vital that coding is consistent between centres. The UK Renal Registry (UKRR) asks clinicians to use the timeline to record the date of first dialysis and separately, the date on which the patient is deemed to have reached ERF. This allows patients who have an acute start to be distinguished from those whose start on RRT was planned.

Published
2018

14. Estimated GFR Reporting Influences Recommendations for Dialysis Initiation

Author

Brimble, K. Scott, primary, Mehrotra, Rajnish, additional, Tonelli, Marcello, additional, Hawley, Carmel M., additional, Castledine, Clare, additional, McDonald, Stephen P., additional, Levidiotis, Vicki, additional, Gangji, Azim S., additional, Treleaven, Darin J., additional, Margetts, Peter J., additional, and Walsh, Michael, additional

Published
2013
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