25 results on '"Cao, Tianqing"'
Search Results
2. Brain–computer interface digital prescription for neurological disorders
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Chai, Xiaoke, primary, Cao, Tianqing, additional, He, Qiheng, additional, Wang, Nan, additional, Zhang, Xuemin, additional, Shan, Xinying, additional, Lv, Zeping, additional, Tu, Wenjun, additional, Yang, Yi, additional, and Zhao, Jizong, additional
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- 2024
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3. Common coupled fixed point theorems in $C^*$-algebra-valued metric spaces
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Cao, Tianqing and Xin, Qiaoling
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Mathematics - Operator Algebras ,Mathematics - Functional Analysis ,47H10 - Abstract
In this paper, we prove some common coupled fixed point theorems for mappings satisfying different contractive conditions in the context of complete $C^*$-algebra-valued metric spaces. Moreover, the paper provides an application to prove the existence and uniqueness of a solution for Fredholm nonlinear integral equations., Comment: 12 pages. arXiv admin note: text overlap with arXiv:1506.05545 by other authors
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- 2016
4. Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.
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Cao, Tianqing, He, Shenghong, Wang, Luchen, Chai, Xiaoke, He, Qiheng, Liu, Dongsheng, Wang, Dong, Wang, Nan, He, Jianghong, Wang, Shouyang, Yang, Yi, Zhao, Jizong, and Tan, Huiling
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DEEP brain stimulation , *CONSCIOUSNESS disorders , *MOVEMENT disorders , *LITERATURE reviews , *SUBTHALAMIC nucleus , *PATIENT selection , *BRAIN injuries - Abstract
Background: The management of patients with disorders of consciousness (DOC) presents substantial challenges in clinical practice. Deep brain stimulation (DBS) has emerged as a potential therapeutic approach, but the lack of standardized regulatory parameters for DBS in DOC hinders definitive conclusions. Objective: This comprehensive review aims to provide a detailed summary of the current issues concerning patient selection, target setting, and modulation parameters in clinical studies investigating the application of DBS for DOC patients. Methods: A meticulous systematic analysis of the literatures was conducted, encompassing articles published from 1968 to April 2023, retrieved from reputable databases (PubMed, Embase, Medline, and Web of Science). Results: The systematic analysis of 21 eligible articles, involving 146 patients with DOC resulting from acquired brain injury or other disorders, revealed significant insights. The most frequently targeted regions were the Centromedian‐parafascicular complex (CM‐pf) nuclei and central thalamus (CT), both recognized for their role in regulating consciousness. However, other targets have also been explored in different studies. The stimulation frequency was predominantly set at 25 or 100 Hz, with pulse width of 120 μs, and voltages ranged from 0 to 4 V. These parameters were customized based on individual patient responses and evaluations. The overall clinical efficacy rate in all included studies was 39.7%, indicating a positive effect of DBS in a subset of DOC patients. Nonetheless, the assessment methods, follow‐up durations, and outcome measures varied across studies, potentially contributing to the variability in reported efficacy rates. Conclusion: Despite the challenges arising from the lack of standardized parameters, DBS shows promising potential as a therapeutic option for patients with DOC. However, there still remains the need for standardized protocols and assessment methods, which are crucial to deepen the understanding and optimizing the therapeutic potential of DBS in this specific patient population. [ABSTRACT FROM AUTHOR]
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- 2024
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5. The Quantum Symmetry in Nonbalanced Hopf Spin Models Determined by a Normal Coideal Subalgebra
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Xin Qiaoling and Cao Tianqing
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Mathematics ,QA1-939 - Abstract
For a finite-dimensional cocommutative semisimple Hopf C∗-algebra H and a normal coideal ∗-subalgebra H1, we define the nonbalanced quantum double DH1;H as the crossed product of H with H1op^, with respect to the left coadjoint representation of the first algebra acting on the second one, and then construct the infinite crossed product AH1=⋯⋊H⋊H1^⋊H⋊H1^⋊H⋊⋯ as the observable algebra of nonbalanced Hopf spin models. Under a right comodule algebra action of DH1;H on AH1, the field algebra can be obtained as the crossed product C∗-algebra. Moreover, we prove there exists a duality between the nonbalanced quantum double DH1;H and the observable algebra AH1.
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- 2021
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6. C ∗ ‐index of observable algebra in the field algebra determined by a normal group
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Xin Qiaoling, Cao Tianqing, and Jiang Lining
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General Mathematics ,General Engineering - Published
- 2021
7. Jones Type Basic Construction on Hopf Spin Models
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Cao Tianqing, Xin Qiaoling, Wei Xiaomin, and Jiang Lining
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Hopf algebras ,observable algebras ,basic construction ,crossed product ,Mathematics ,QA1-939 - Abstract
Let H be a finite dimensional C∗-Hopf algebra and A the observable algebra of Hopf spin models. For some coaction of the Drinfeld double D(H) on A, the crossed product A⋊D(H)^ can define the field algebra F of Hopf spin models. In the paper, we study C∗-basic construction for the inclusion A⊆F on Hopf spin models. To achieve this, we define the action α:D(H)×F→F, and then construct the resulting crossed product F⋊D(H), which is isomorphic A⊗End(D(H)^). Furthermore, we prove that the C∗-basic construction for A⊆F is consistent to F⋊D(H), which yields that the C∗-basic constructions for the inclusion A⊆F is independent of the choice of the coaction of D(H) on A.
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- 2020
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8. Vascularization converts the lineage fate of bone mesenchymal stem cells to endothelial cells in tissue-engineered bone grafts by modulating FGF2-RhoA/ROCK signaling
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Li, Donglin, Cheng, Pengzhen, Jiang, Huijie, Cao, Tianqing, Wang, Jimeng, Gao, Yi, Lin, Yangjing, Wang, Chunmei, Zhang, Shuaishuai, Li, Junqin, Liu, Bin, Song, Yue, Yang, Liu, and Pei, Guoxian
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- 2018
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9. Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts
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Cheng, Pengzhen, Li, Donglin, Gao, Yi, Cao, Tianqing, Jiang, Huijie, Wang, Jimeng, Li, Junqin, Zhang, Shuaishuai, Song, Yue, Liu, Bin, Wang, Chunmei, Yang, Liu, and Pei, Guoxian
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- 2018
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10. Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion
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Sheng Miao, Liu Yang, Wang Long, Xueyi Zhao, Gao Yi, Dong Wang, Cheng Pengzhen, Ning Fenru, Guoxian Pei, Cao Tianqing, and Weiguang Lu
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QH301-705.5 ,Chemistry ,Angiogenesis ,Biomedical Engineering ,Bone healing ,Extracellular vesicles ,Bone tissue engineering ,Cell biology ,Biomaterials ,Endothelial stem cell ,Focal adhesion ,Extracellular matrix ,Hydrogel ,Tissue engineering ,TA401-492 ,Biology (General) ,Nidogen1 ,Bone regeneration ,Materials of engineering and construction. Mechanics of materials ,Intracellular ,Biotechnology - Abstract
The technique bottleneck of repairing large bone defects with tissue engineered bone is the vascularization of tissue engineered grafts. Although some studies have shown that extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) promote bone healing and repair by accelerating angiogenesis, the effector molecules and the mechanism remain unclear, which fail to provide ideas for the future research and development of cell-free interventions. Here, we found that Nidogen1-enriched EV (EV-NID1) derived from BMSCs interferes with the formation and assembly of focal adhesions (FAs) by targeting myosin-10, thereby reducing the adhesion strength of rat arterial endothelial cells (RAECs) to the extracellular matrix (ECM), and enhancing the migration and angiogenesis potential of RAECs. Moreover, by delivery with composite hydrogel, EV-NID1 is demonstrated to promote angiogenesis and bone regeneration in rat femoral defects. This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism, thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products.
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- 2021
11. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System
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Junqin Li, Guoxian Pei, Li Donglin, Yue Song, Hao Wu, Cao Tianqing, Chunmei Wang, Wang Jimeng, Liu Yang, Gao Yi, Liu Bin, Cheng Pengzhen, Shuaishuai Zhang, and Jiang Huijie
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0301 basic medicine ,Homeobox protein NANOG ,lcsh:Internal medicine ,Article Subject ,Chemistry ,Autophagy ,AMPK ,Cell Biology ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,medicine.anatomical_structure ,stomatognathic system ,Dorsal root ganglion ,SOX2 ,Downregulation and upregulation ,Adipogenesis ,medicine ,lcsh:RC31-1245 ,Molecular Biology ,PI3K/AKT/mTOR pathway ,Research Article - Abstract
Our previous studies found that sensory nerve tracts implanted in tissue-engineered bone (TEB) could result in better osteogenesis. To explore the mechanism of the sensory nerve promoting osteogenesis in TEB in vitro, a transwell coculture experiment was designed between dorsal root ganglion (DRG) cells and bone marrow mesenchymal stem cells (BMSCs). BMSC proliferation was determined by CCK8 assay, and osteo-, chondro-, and adipogenic differentiation were assessed by alizarin red, alcian blue, and oil red staining. We found that the proliferation and multipotent differentiation of BMSCs were all enhanced in the coculture group compared to the BMSCs group. Crystal violet staining showed that the clone-forming ability of BMSCs in the coculture group was also enhanced and mRNA levels of Sox2, Nanog, and Oct4 were significantly upregulated in the coculture group. Moreover, the autophagy level of BMSCs, regulating their stemness, was promoted in the coculture group, mediated by the AMPK/mTOR pathway. In addition, AMPK inhibitor compound C could significantly downregulate the protein expression of LC3 and the mRNA level of stemness genes in the coculture group. Finally, we found that the NK1 receptor antagonist, aprepitant, could partly block this effect, which indicated that substance P played an important role in the effect. Together, we conclude that DRG could maintain the stemness of BMSCs by enhancing autophagy through the AMPK/mTOR pathway in a transwell coculture system, which may help explain the better osteogenesis after implantation of the sensory nerve into TEB.
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- 2018
12. Vascularization converts the lineage fate of bone mesenchymal stem cells to endothelial cells in tissue-engineered bone grafts by modulating FGF2-RhoA/ROCK signaling
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Chunmei Wang, Liu Yang, Cao Tianqing, Guoxian Pei, Li Donglin, Junqin Li, Jiang Huijie, Yangjing Lin, Yue Song, Liu Bin, Cheng Pengzhen, Shuaishuai Zhang, Gao Yi, and Wang Jimeng
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0301 basic medicine ,Cancer Research ,Bone Regeneration ,RHOA ,Immunology ,Basic fibroblast growth factor ,Cell fate determination ,Bone and Bones ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Tissue engineering ,Animals ,Humans ,lcsh:QH573-671 ,Protein kinase A ,Bone regeneration ,rho-Associated Kinases ,Tissue Engineering ,biology ,lcsh:Cytology ,Regeneration (biology) ,Mesenchymal stem cell ,Endothelial Cells ,Mesenchymal Stem Cells ,Cell Biology ,Rats ,Cell biology ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Fibroblast Growth Factor 2 ,rhoA GTP-Binding Protein - Abstract
The prevascularization of tissue-engineered bone grafts (TEBGs) has been shown to accelerate capillary vessel ingrowth in bone defect remodeling and to enhance new bone formation. However, the exact mechanisms behind this positive effect remain unknown. Here, we report that basic fibroblast growth factor (FGF2)-Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling functions as a molecular switch to regulate the lineage fate of bone mesenchymal stem cells (BMSCs) and that prevascularization promotes the cell fate switch, which contributes to increased bone regeneration with the use of prevascularized TEBGs compared with control TEBGs. Prevascularized TEBGs enhanced the in vivo endothelial differentiation of BMSCs by inhibiting RhoA/ROCK signaling. In vitro data more clearly showed that BMSCs differentiated into von Willebrand factor (vWF)-positive endothelial cells, and FGF2-induced inhibition of RhoA/ROCK signaling played a key role. Our novel findings uncovered a new mechanism that stimulates the increased vascularization of engineered bone and enhanced regeneration by promoting the endothelial differentiation of BMSCs implanted in TEBGs. These results offer a new molecular target to regulate TEBG-induced bone regeneration.
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- 2018
13. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin
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Cao Tianqing, Guoxian Pei, Chunmei Wang, Yue Song, Long Bi, Kaifeng Lin, Wang Jimeng, Shu He, Li Donglin, and Shuaishuai Zhang
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0301 basic medicine ,bone substitutes ,Pharmaceutical Science ,platelet-rich fibrin ,Biocompatible Materials ,02 engineering and technology ,Polyvinyl alcohol ,chemistry.chemical_compound ,Tissue engineering ,International Journal of Nanomedicine ,Osteogenesis ,Drug Discovery ,nano-biphasic calcium phosphate ,Ceramic ,three-dimensional printing ,Original Research ,Tissue Scaffolds ,Cell Differentiation ,General Medicine ,Adhesion ,021001 nanoscience & nanotechnology ,Platelet-rich fibrin ,Cold Temperature ,polyvinyl alcohol ,visual_art ,tissue engineering ,Printing, Three-Dimensional ,visual_art.visual_art_medium ,Intercellular Signaling Peptides and Proteins ,Hydroxyapatites ,Rabbits ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions ,Materials science ,Biocompatibility ,education ,Biophysics ,Bioengineering ,Bone healing ,Bone and Bones ,Biomaterials ,03 medical and health sciences ,Nano ,Cell Adhesion ,Animals ,Cell Proliferation ,Wound Healing ,Organic Chemistry ,Mesenchymal Stem Cells ,X-Ray Microtomography ,Alkaline Phosphatase ,030104 developmental biology ,Freeze Drying ,chemistry ,Nanoparticles ,Biomedical engineering - Abstract
Yue Song,1,* Kaifeng Lin,2,* Shu He,3,* Chunmei Wang,1 Shuaishuai Zhang,1 Donglin Li,1 Jimeng Wang,4 Tianqing Cao,1 Long Bi,1 Guoxian Pei1 1Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi’an, China; 2Second Department of Orthopedics and Traumatology, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou, China; 3Department of Orthopedics, Xi’an Hong Hui Hospital, Xi’an, China; 4Department of Orthopedics, The 251st Hospital of Chinese PLA, Zhangjiakou, China *These authors contributed equally to this work Background and aim: As a newly emerging three-dimensional (3D) printing technology, low-temperature robocasting can be used to fabricate geometrically complex ceramic scaffolds at low temperatures. Here, we aimed to fabricate 3D printed ceramic scaffolds composed of nano-biphasic calcium phosphate (BCP), polyvinyl alcohol (PVA), and platelet-rich fibrin (PRF) at a low temperature without the addition of toxic chemicals.Methods: Corresponding nonprinted scaffolds were prepared using a freeze-drying method. Compared with the nonprinted scaffolds, the printed scaffolds had specific shapes and well-connected internal structures.Results: The incorporation of PRF enabled both the sustained release of bioactive factors from the scaffolds and improved biocompatibility and biological activity toward bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. Additionally, the printed BCP/PVA/PRF scaffolds promoted significantly better BMSC adhesion, proliferation, and osteogenic differentiation in vitro than the printed BCP/PVA scaffolds. In vivo, the printed BCP/PVA/PRF scaffolds induced a greater extent of appropriate bone formation than the printed BCP/PVA scaffolds and nonprinted scaffolds in a critical-size segmental bone defect model in rabbits.Conclusion: These experiments indicate that low-temperature robocasting could potentially be used to fabricate 3D printed BCP/PVA/PRF scaffolds with desired shapes and internal structures and incorporated bioactive factors to enhance the repair of segmental bone defects. Keywords: three-dimensional printing, nano-biphasic calcium phosphate, polyvinyl alcohol, platelet-rich fibrin, bone substitutes, tissue engineering
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- 2018
14. CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
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Ji Chuanlei, Chao Shen, Jiang Huijie, Cao Tianqing, Wang Jimeng, Liu Yang, Guoxian Pei, Yue Song, Li Donglin, Gao Yi, Cheng Pengzhen, Junqin Li, Chunmei Wang, and Shuaishuai Zhang
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0301 basic medicine ,CD31 ,Vascular Endothelial Growth Factor A ,Angiogenesis ,Science ,Bone Morphogenetic Protein 2 ,Down-Regulation ,Neovascularization, Physiologic ,Metaphysis ,Biology ,Bone morphogenetic protein 2 ,Article ,Neovascularization ,03 medical and health sciences ,Osteogenesis ,medicine ,Animals ,Endosteum ,Multidisciplinary ,Tibia ,Bone Injury ,Anatomy ,Hypoxia-Inducible Factor 1, alpha Subunit ,Rats ,Endothelial stem cell ,030104 developmental biology ,medicine.anatomical_structure ,Cancellous Bone ,cardiovascular system ,Medicine ,Female ,medicine.symptom ,Transcription Factors - Abstract
CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the distribution of these vessels in rat tibiae and their temporal and spatial distribution during the bone defect repair process to improve our understanding of the importance of these vessels. We confirmed that CD31hiEmcnhi vessels were specially distributed around the trabecular bones near metaphysis and endosteum in rat tibiae. At 3 days post bone injury, CD31hiEmcnhi vessels proliferated and were extensively distributed across the entire repair area. At 7 and 14 days post-injury, these vessels decreased but were specially distributed around the growing trabecular bones near the frontier growth area, suggesting that these vessels support new bone formation. The distribution of CD31hiEmcnhi vessels and the transcriptions of Hif-1α and VEGFA, as well as BMP2 and Osterix decreased at 7 and 14 days post-injury under osteoporotic conditions, in combination with insufficient osteogenesis. Our research is of great significance to help understand the important role of CD31hiEmcnhi vessels in supporting new trabecular bones formation during bone defect repair process.
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- 2017
15. C⁎-Basic Construction from the Conditional Expectation on the Drinfeld Double
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Xin, Qiaoling, Jiang, Lining, and Cao, Tianqing
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Article Subject ,lcsh:Mathematics ,lcsh:QA1-939 - Abstract
Let D(G) be the Drinfeld double of a finite group G and D(G;H) be the crossed product of C(G) and CH, where H is a subgroup of G. Then the sets D(G) and D(G;H) can be made C⁎-algebras naturally. Considering the C⁎-basic construction C⁎〈D(G),e〉 from the conditional expectation E of D(G) onto D(G;H), one can construct a crossed product C⁎-algebra C(G/H×G)⋊CG, such that the C⁎-basic construction C⁎〈D(G),e〉 is C⁎-algebra isomorphic to C(G/H×G)⋊CG.
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- 2019
16. Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts
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Gao Yi, Jiang Huijie, Guoxian Pei, Liu Bin, Li Donglin, Wang Jimeng, Cheng Pengzhen, Liu Yang, Cao Tianqing, Shuaishuai Zhang, Yue Song, Junqin Li, and Chunmei Wang
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Calcium Phosphates ,0301 basic medicine ,Angiogenesis ,medicine.medical_treatment ,Neovascularization, Physiologic ,Medicine (miscellaneous) ,Connective tissue ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Fibrin ,Animals, Genetically Modified ,lcsh:Biochemistry ,03 medical and health sciences ,Tissue engineering ,medicine ,Animals ,lcsh:QD415-436 ,Connective tissue growth factor ,lcsh:R5-920 ,Bone Transplantation ,Tissue Engineering ,Tissue Scaffolds ,biology ,Chemistry ,Research ,Growth factor ,Fibrinogen ,Cell migration ,Cell Biology ,Rats ,Cell biology ,Transplantation ,CTGF ,030104 developmental biology ,medicine.anatomical_structure ,biology.protein ,Tissue-engineered bone grafts ,Molecular Medicine ,Female ,Prevascularization ,lcsh:Medicine (General) - Abstract
Background Vascularization is one of the most important processes in tissue-engineered bone graft (TEBG)-mediated regeneration of large segmental bone defects. We previously showed that prevascularization of TEBGs promoted capillary vessel formation within the defected site and accelerated new bone formation. However, the precise mechanisms and contribution of endogenous cells were not explored. Methods We established a large defect (5 mm) model in the femur of EGFP+ transgenic rats and implanted a β-tricalcium phosphate (β-TCP) scaffold seeded with exogenous EGFP− cells; the femoral vascular bundle was inserted into the scaffold before implantation in the prevascularized TEBG group. Histopathology and scanning electron microscopy were performed and connective tissue growth factor (CTGF) and fibrin expression, exogenous cell survival, endogenous cell migration and behavior, and collagen type I and III deposition were assessed at 1 and 4 weeks post implantation. Results We found that the fibrinogen content can be increased at the early stage of vascular bundle transplantation, forming a fibrin reticulate structure and tubular connections between pores of β-TCP material, which provides a support for cell attachment and migration. Meanwhile, CTGF expression is increased, and more endogenous cells can be recruited and promote collagen synthesis and angiogenesis. By 4 weeks post implantation, the tubular connections transformed into von Willebrand factor-positive capillary-like structures with deposition of type III collagen, and accelerated angiogenesis of endogenous cells. Conclusions These findings demonstrate that prevascularization promotes the recruitment of endogenous cells and collagen deposition by upregulating fibrinogen and CTGF, directly resulting in new blood vessel formation. In addition, this molecular mechanism can be used to establish fast-acting angiogenesis materials in future clinical applications. Electronic supplementary material The online version of this article (10.1186/s13287-018-0925-y) contains supplementary material, which is available to authorized users.
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- 2018
17. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System
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Zhang, Shuaishuai, primary, Li, Junqin, additional, Jiang, Huijie, additional, Gao, Yi, additional, Cheng, Pengzhen, additional, Cao, Tianqing, additional, Li, Donglin, additional, Wang, Jimeng, additional, Song, Yue, additional, Liu, Bin, additional, Wu, Hao, additional, Wang, Chunmei, additional, Yang, Liu, additional, and Pei, Guoxian, additional
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- 2018
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18. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin
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Song, Yue, primary, Lin, Kaifeng, additional, He, Shu, additional, Wang, Chunmei, additional, Zhang, Shuaishuai, additional, Li, Donglin, additional, Wang, Jimeng, additional, Cao, Tianqing, additional, Bi, Long, additional, and Pei, Guoxian, additional
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- 2018
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19. CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
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Wang, Jimeng, primary, Gao, Yi, additional, Cheng, Pengzhen, additional, Li, Donglin, additional, Jiang, Huijie, additional, Ji, Chuanlei, additional, Zhang, Shuaishuai, additional, Shen, Chao, additional, Li, Junqin, additional, Song, Yue, additional, Cao, Tianqing, additional, Wang, Chunmei, additional, Yang, Liu, additional, and Pei, Guoxian, additional
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- 2017
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20. Geothermal observations in east Liaoning and haicheng seismic area
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Wang Andong, Ren Yuhe, Sun Wenfu, Yu Longwei, Liang Jingming, Cao Tianqing, and Gu Haoding
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- 1988
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21. Processed Strong-Motion Records from the Limón, Costa Rica Earthquake of 22 April 1991
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Darragh, Robert, Cao, Tianqing Q., Cramer, Chris H., Shakal, Anthony F., and Santana Barboza, Guillermo
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Costa Rica ,Limon earthquake ,Accelerogram ,Strong motion ,Processed records - Abstract
Están disponibles los registros digitales obtenidos para uso de los investigadores interesados en estudiar la severidad del terremoto desde el punto de vista instrumental. Se incluyen los acelerogramas obtenidos con equipo Kinemetrics SMA-1 y sus correspondientes integraciones, velocidades y desplazamientos. Se trata de archivos de caracteres ASCII fácilmente legible por medio de diferentes rutinas de análisis de datos. Strong-motion records were recovered from 15 accelerographs at 14 stations operated by the Strong Motion Instrumentation Program of the Earthquake Engineering Laboratory (EEL) at the University of Costa Rica (Santana and others, 1991) following the damaging Limón, Costa Rica earthquake of April 22, 1991. The sites range in epicentral distance from 73 to 160 km; peak horizontal accelerations at ground level ranged from 0.03 to 0.27 g. The accelerograms are characterized by long duration of strong shaking, of approximately 30 seconds. An extensive strong motion data set from a moment magnitude (Mw) 7.5 earthquake is rare. Because of the importance of these data not only to Costa Rica but also to California, the California Strong Motion Instrumentation Program (CSMIP), in cooperation with the University of Costa Rica, digitized and processed these data for distribution to engineers, seismologists and others concerned with the seismic safety problem. This processed data is the second extensive set of data from an earthquake with magnitude between the magnitude 7 Lorna Prieta earthquake and the magnitude 7.8 Chile and Tabas, Iran earthquakes. Universidad de Costa Rica/[]/UCR/Costa Rica UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ingeniería::Instituto Investigaciones en Ingeniería (INII)
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- 1995
22. WGCEP historical California earthquake catalog
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Felzer, Karen R., primary and Cao, Tianqing, additional
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- 2008
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23. Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion
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Cheng, Pengzhen, Cao, Tianqing, Zhao, Xueyi, Lu, Weiguang, Miao, Sheng, Ning, Fenru, Wang, Dong, Gao, Yi, Wang, Long, Pei, Guoxian, and Yang, Liu
- Abstract
The technique bottleneck of repairing large bone defects with tissue engineered bone is the vascularization of tissue engineered grafts. Although some studies have shown that extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) promote bone healing and repair by accelerating angiogenesis, the effector molecules and the mechanism remain unclear, which fail to provide ideas for the future research and development of cell-free interventions. Here, we found that Nidogen1-enriched EV (EV-NID1) derived from BMSCs interferes with the formation and assembly of focal adhesions (FAs) by targeting myosin-10, thereby reducing the adhesion strength of rat arterial endothelial cells (RAECs) to the extracellular matrix (ECM), and enhancing the migration and angiogenesis potential of RAECs. Moreover, by delivery with composite hydrogel, EV-NID1 is demonstrated to promote angiogenesis and bone regeneration in rat femoral defects. This study identifies the intracellular binding target of EV-NID1 and further elucidates a novel approach and mechanism, thereby providing a cell-free construction strategy with precise targets for the development of vascularized tissue engineering products.
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- 2021
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24. Anatomical-related factors and outcome of percutaneous short-term spinal cord stimulation electrode shift in patients with disorders of consciousness: a retrospective study.
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He Q, Yang C, Xu Y, Niu H, Wu H, Huang H, Chai X, Cao T, Wang N, Wong P, He J, Yang Y, and Zhao J
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Background: Disorders of consciousness (DoC) represent a spectrum of neurological conditions that pose significant treatment challenges. Percutaneous short-term spinal cord stimulation (SCS) has emerged as a promising experimental diagnostic treatment to assess and potentially improve consciousness levels. However, the effectiveness of this intervention is frequently compromised by the shift of electrodes, particularly in the cervical region, which can negatively affect therapeutic outcomes., Methods: This retrospective study aimed to study if electrodes shift in percutaneous short-term SCS in patients with DoC would affect the outcome. We analyzed the relationship between electrode shift length and patient outcome, as well as the correlation with various anatomical parameters, including the actual length of the cervical spine, linear length, spinal canal transverse diameter, spinal canal diameter, and C2 cone height, in a cohort of patients undergoing the procedure., Results: Our findings revealed that in patients with better outcome, there are significant less patient with electrode shift ( p = 0.019). Further, a linear correlation was found between the length of electrode shift and patients' outcome (Rho = 0.583, p = 0.002), with longer shift lengths associated with poorer outcomes. Contrary to our expectations, there was no significant association between the measured anatomical parameters and the extent of electrode shift. However, a trend was found between the actual length of the cervical spine and the shift of the electrode ( p = 0.098). Notably, the shorter spinal canal transverse diameter was found to be significantly associated with better outcome in patients with DoC receiving percutaneous short-term SCS ( p = 0.033)., Conclusion: These results highlight the clinical importance of electrode stability in the cervical region during SCS treatment for patients with DoC. Ensuring secure placement of electrodes may play a crucial role in enhancing patients' outcome and minimize postoperative complications. Given the lack of association with expected anatomical parameters, future research should investigate other factors that could impact electrode stability to optimize this therapeutic intervention., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 He, Yang, Xu, Niu, Wu, Huang, Chai, Cao, Wang, Wong, He, Yang and Zhao.)
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- 2024
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25. Preoperative nomogram predicting ventriculoperitoneal shunt longevity after initial shunt failure.
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Liu D, He Q, Niu J, Li L, Geng R, Cao T, Wang X, Lv Z, He J, Zhao J, Chen G, and Yang Y
- Abstract
Background and Objectives: Initial shunt failure following ventriculoperitoneal (VP) shunt surgery has a significant impact on the working time of the shunt. However, there are few studies regarding factors affecting VP shunt longevity. Hence, in this study, we aimed to build a nomogram to predict the longevity of the replacement VP shunt in patients with initial shunt failure., Methods: From 2011 to 2021, 142 patients with initial VP failure who underwent VP shunt revision were enrolled and relevant clinical and demographic factors were analyzed. Univariate and multivariate Cox proportional hazard regression models were used to choose predictors, and a nomogram was constructed using nine independent prognostic variables: sex, age, hydrocephalus type, intensive care unit admission, tracheostomy, decompressive craniectomy, craniotomy, lumbar cisterna drainage, and ventricular drainage. The prediction models' discrimination, accuracy, calibration, and clinical value were evaluated using Harrell's C-index, a calibration plot, and decision curve analysis., Results: At 1 month, 3 months, and 5 years, the nomogram's C-index was 0.680, 0.708, and 0.694, respectively. The nomogram's calibration plot provided a good fit for the overall prediction over the course of 1 year. Decision curve analysis predicted that 1-3 months after surgery will yield good net benefits between 30 and 50% probability thresholds., Conclusion: A preoperative nomogram may be an effective tool for assessing VP shunt longevity after initial VP shunt placement., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Liu, He, Niu, Li, Geng, Cao, Wang, Lv, He, Zhao, Chen and Yang.)
- Published
- 2024
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