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1. Doença de Crohn e probióticos: uma revisão

Author

Camila Maria Simplicio Revoredo, Jorgiana Libânio, Kalene Frazão, and Mísia Cunha

Subjects
Probióticos, Doença de Crohn, Terapia Nutricional, DOENÇA DE CRHON, DOENÇA DE CRHON/dietoterapia, PROBIÓTICOS, Nutritional diseases. Deficiency diseases, RC620-627, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Objetivo: Apresentar uma revisão sobre o papel dos probióticos na terapia nutricional na Doença de Crohn. Métodos: Foi realizada uma revisão bibliográfica nas bases de dados eletrônicas: Scielo, Pubmed, Biblioteca Virtual em Saúde (BVS) e Google Acadêmico, abrangendo publicações entre 2011 e 2016, com idiomas em língua portuguesa e inglesa. Resultados: A Doença de Crohn envolve um processo inflamatório que afeta várias partes do trato gastrointestinal, nesse sentido, vários estudos têm demonstrado ações benéficas com o uso de probióticos, entre elas, produção de Ácidos Graxos de Cadeia Curta (AGCC), redução da intolerância à lactose, controle da diarreia aguda, melhora da atividade clínica da doença e prevenção de recidivas das doenças inflamatórias intestinais. Conclusão: Os probióticos oferecem benefícios aos pacientes com doença de Crohn, podendo reduzir sintomas como diarreia e melhorar a imunidade destes pacientes, contudo, ainda não há um consenso em relação à recomendação do uso destes em seres humanos. Portanto, faz-se necessário à formulação de pesquisas, que visem estudar a eficiência e a segurança da imunonutrição nesses pacientes.

Published
2018

2. Expression of Nrf2 and NF-κB transcription factors in breast cancer and breast fibroadenoma: Insights for a new therapeutic approach

Author

Rodrigo Jose de Vasconcelos-Valença, Paulo de Tarso Moura-Borges, Aldenora Oliveira do Nascimento-Holanda, Mariella de Almeida Melo, Larysse Cardoso Campos-Verdes, Emerson Brandão Sousa, Camila Guedes Borges de Araújo, Lina Gomes dos Santos, Jackeline Lopes Viana, Benedito Borges da Silva, Pedro Vitor Lopes-Costa, André Luiz Pinho-Sobral, Fidelis Manes Neto, Renato de Oliveira Pereira, Viriato Campelo, Luiz Henrique Gebrim, Lauro Rodolpho Soares-Lopes, Ione Maria Ribeiro Soares-Lopes, Cléciton Braga Tavares, Alesse Ribeiro dos Santos, Camila Maria Simplicio-Revoredo, Eid Gonçalves Coelho, Maria da Conceição Barros-Oliveira, and Maria Liduina Meneses Bezerra-Chaves

Subjects
0301 basic medicine, Oncology, fibroadenoma, medicine.medical_specialty, NF-κB, NRF2, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, Statistical significance, Breast Fibroadenoma, Internal medicine, medicine, Transcription factor, business.industry, Cancer, Institutional review board, medicine.disease, Fibroadenoma, 030104 developmental biology, 030220 oncology & carcinogenesis, immunohistochemistry, Immunohistochemistry, business, Research Paper
Abstract

Background: Cancer and fibroadenoma are the most common breast tumors in women of reproductive age. Nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappaB (NF-κB) transcription factor play an important role in the inflammatory process and in cell proliferation. However, few studies have analyzed these markers in breast cancer and fibroadenoma in women of reproductive age. Results: Light microscopy showed a higher concentration of anti-Nrf2 and anti-NF-κB-stained nuclei in breast cancer than in fibroadenoma. The mean percentage of stained nuclei for Nrf2 was 7.12 ± 5.2 and 43.21 ± 19.83 in the control and study groups, respectively (p < 0.0001). The mean percentage of anti-NF-κB was 10.75 ± 7.09 and 56.14 ± 21.19 (mean ± standard deviation) in the control and study groups, respectively (p < 0.0001). Histological grade 3 tumors showed a significantly higher expression of Nrf2 and NF-κB than grade 1 tumors (p < 0.05). Material and methods: This study was approved by the Institutional Review Board of Federal University of Piaui and all patients assigned an inform consent term prior to the study initiation. Nrf2 and NF-κB expression was evaluated by immunohistochemistry in 66 patients, divided into two groups, control (fibroadenoma, n = 36) and study (cancer, n = 30). The data were analyzed using ANOVA test and the statistical significance was established at p < 0.05. Conclusion: Nrf2 and NF-κB expression was significantly higher in breast cancer than in fibroadenoma, in addition to having a greater association with more aggressive tumors.

Published
2020

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