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Objective: To compare components of glycemic and energy homeostasis in women with metabolically healthy normal weight (MHNW) and metabolically unhealthy (MUNW), metabolically unhealthy overweight/obese (MUO) and metabolically healthy (MHO) phenotypes. Methodology: Cross-sectional study with 104 women (18-45 years): 30 MHNW, 17 MUNW, 27 MHO, 30 MUO. Overweight was considered BMI ≥ 25 kg/m² and metabolic health without of changes in blood pressure, glycemic, lipemic levels and cardiovascular disease. The standard mixed meal tolerance test and indirect calorimetry were performed (assessments at -15, 0, 30, 60, 120 and 180 min). The quantifications were: areas under the curve (AUC) for glucose, insulin, C peptide, glucagon and GLP-1; insulin sensitivity (IS) by oral glucose insulin sensitivity index; energy expenditure, respiratory quotient, and carbohydrate and lipid oxidation rate were measured at rest and after oral stimulation. Results: The groups did not differ regarding age and HbA1c levels. IS was decreased in MUO compared to MHNW and MHO (p Conclusion: In young and normoglycemic women, there was lower IS and insulin secretion for the MUO phenotype. The greater rate of lipid oxidation in this group compared to the lean ones may be a reflection of the lower IS, and the inability to switch the use of energy substrate to the higher carbohydrate availability after oral stimulation. BMI is not an ideal indicator of the presence or absence of metabolic health. However, even in MHO individuals’, physiological adaptations may happen to maintain the metabolic parameters within normal range. Disclosure F.B. Ribeiro: None. I. Solar: None. R.G. Freitas: None. A.S. Hanada: None. M.G. Barbosa: None. C.M. Xavier: None. N.S.K. Crouchan: None. V.F.D. Santos: None. B.G. Neto: None. I.T. Silva: None. L.G.D. Folchetti: None. B. Almeida Pititto: None. S.G. Ferreira-Vivolo: None. A.J. Vasques: None. Funding Fundação de Apoio a Pesquisa do Estado de São Paulo (2017/10185-9)

Introduction: Many studies report that environmental factors occurring in childhood may modulate the composition of the gut microbiota in adulthood, which in turn, produces short chain fatty acids (SCFA) with metabolic effects on inflammatory cascades associated with glycemic homeostasis. Objective: This study aims to analyze associations between type of delivery (vaginal/cesarean section), type of breast-feeding (maternal/artificial) and solid food introduction (start and quality) with fecal SCFA concentrations in women. Method: A cross-sectional study including 106 women, 28±5 years old and BMI 25±5 kg/m2, a questionnaire regarding from birth until the first year of life. For quantification of acetate, butyrate and propionate it was used gas chromatography-mass spectrometry in fecal samples. Results: Of the women surveyed 63% were cesarean delivered and 93% received maternal breast milk at some point. There was no correlation between SCFA concentration and type of delivery (p>0.05). Positive correlation was found between breastfeeding time and butyrate (r=0.24; p=0.02), there was a tendency with propionate (r=0.20; p=0.06). There was no correlation between time received infant formula and SCFA. There was a tendency of correlation between butyrate and beginning of cow’s milk intake (r=0.194; p=0.052). Age at solid food introduction correlates with propionate (r=0.22; p=0.026) and butyrate (r=0.25; p=0.012), and report a tendency with the acetate (r=0.18; p=0.07). In the first year of life, individuals who prefer salty crackers and pasta/potatoes had less concentration of propionate and acetate, respectively (p=0.026). Conclusion: The type of delivery was not associated with SCFA, but there was a favorable association with prolonged breastfeeding, late beginning of cow’s milk intake, introduction of solids starting after 6 months of age and lower intake of refined cereals. Disclosure M.G. Barbosa: None. I. Solar: None. R.G. Freitas: None. F.B. Ribeiro: None. C.O. Ramos: None. M.R. Sant’Ana: None. A.S. Hanada: None. N.S.K. Crouchan: None. C.M. Xavier: None. B.G. Neto: None. L.G.D. Folchetti: None. I.T. Silva: None. B. Almeida-Pititto: None. S.G. Ferreira-Vivolo: None. A.J. Vasques: None. Funding São Paulo Research Foundation (2017/10185-9, 2019/05450-0)

A obesidade e caracterizada por uma doenca cronica nao transmissivel, podendo resultar em diferentes fenotipos metabolicos. Um dado de extrema importância para um bom planejamento na pratica clinica do nutricionista e o gasto energetico de repouso, podendo ser estimado por equacoes preditivas ou mensurado pela calorimetria indireta, metodo padrao-ouro. O presente trabalho e um estudo transversal, parte do Nutritionists Health Study - NutriHS, que teve como objetivo comparar o gasto energetico de repouso estimado por 12 equacoes preditivas versus o mensurado por calorimetria indireta em 78 jovens mulheres agrupadas em quatro diferentes fenotipos metabolicos e de adiposidade corporal. Para os quatro grupos estudados, foi possivel observar que a equacao com melhor acuracia individual e populacional foi a de Owen 2, que leva em consideracao a composicao corporal do individuo. A maioria das equacoes comumente utilizadas superestimaram o gasto energetico de repouso em mais de 50%, sugerindo que sua utilizacao na pratica clinica e em pesquisa deve ser feita com cautela.

A obesidade e uma doenca multifatorial associada a diversas comorbidades. Com prevalencia crescente, torna-se fundamental a avaliacao nutricional nestes individuos. Novos indices para avaliacao da adiposidade corporal tem sido propostos como ferramentas de baixo custo, eficacia e praticidade¹²³. Objetivou-se avaliar se os indices de adiposidade corporal (IAC), de forma corporal (IFC), e massa gorda relativa (MGR) diferem dos marcadores antropometricos tradicionais (indice de massa corporal- IMC, circunferencia de cintura- CC e relacao cintura quadril- RCQ) na identificacao de um perfil metabolico desfavoravel e na avaliacao da adiposidade corporal em mulheres.