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5. Reproductive (epi)genetics

Author

Lynch, C., primary, Tee, N., additional, Rouse, H., additional, Gordon, A., additional, Sati, L., additional, Zeiss, C., additional, Soygur, B., additional, Bassorgun, I., additional, Goksu, E., additional, Demir, R., additional, McGrath, J., additional, Groendahl, M. L., additional, Thuesen, L., additional, Andersen, A. N., additional, Loft, A., additional, Smitz, J., additional, Adriaenssens, T., additional, Vikesa, J., additional, Borup, R., additional, Mersy, E., additional, Kisters, N., additional, Macville, M. V. E., additional, Engelen, J. J. M., additional, Consortium, S.-E. N. N., additional, Menheere, P. P. C. A., additional, Geraedts, J. P., additional, Coumans, A. B. C., additional, Frints, S. G. M., additional, Aledani, T., additional, Assou, S., additional, Traver, S., additional, Ait-ahmed, O., additional, Dechaud, H., additional, Hamamah, S., additional, Mizutani, E., additional, Suzumori, N., additional, Sugiyama, C., additional, Hattori, Y., additional, Sato, T., additional, Ando, H., additional, Ozaki, Y., additional, Sugiura-Ogasawara, M., additional, Wissing, M., additional, Kristensen, S. G., additional, Andersen, C. Y., additional, Mikkelsen, A. L., additional, Hoest, T., additional, Velthut-Meikas, A., additional, Simm, J., additional, Metsis, M., additional, Salumets, A., additional, Palini, S., additional, Galluzzi, L., additional, De Stefani, S., additional, Primiterra, M., additional, Wells, D., additional, Magnani, M., additional, Bulletti, C., additional, Vogt, P. H., additional, Frank-Herrmann, P., additional, Bender, U., additional, Strowitzki, T., additional, Besikoglu, B., additional, Heidemann, P., additional, Wunsch, L., additional, Bettendorf, M., additional, Jelinkova, L., additional, Vilimova, S., additional, Kosarova, M., additional, Sebek, P., additional, Volemanova, E., additional, Kruzelova, M., additional, Civisova, J., additional, Svobodova, L., additional, Sobotka, V., additional, Mardesic, T., additional, van de Werken, C., additional, Santos, M. A., additional, Eleveld, C., additional, Laven, J. S. E., additional, Baart, E. B., additional, Pylyp, L. Y., additional, Spinenko, L. A., additional, Zukin, V. D., additional, Perez-Sanz, J., additional, Matorras, R., additional, Arluzea, J., additional, Bilbao, J., additional, Gonzalez-Santiago, N., additional, Yeh, N., additional, Koff, A., additional, Barlas, A., additional, Romin, Y., additional, Manova-Todorova, K., additional, Hoz, C. D. l., additional, Mauri, A. L., additional, Nascimento, A. M., additional, Vagnini, L. D., additional, Petersen, C. G., additional, Ricci, J., additional, Massaro, F. C., additional, Cavagna, M., additional, Pontes, A., additional, Oliveira, J. B. A., additional, Baruffi, R. L. R., additional, Franco, J. G., additional, Wu, E. X., additional, Ma, S., additional, Parriego, M., additional, Sole, M., additional, Boada, M., additional, Coroleu, B., additional, Veiga, A., additional, Kakourou, G., additional, Poulou, M., additional, Vrettou, C., additional, Destouni, A., additional, Traeger-Synodinos, J., additional, Kanavakis, E., additional, Yatsenko, A. N., additional, Georgiadis, A. P., additional, McGuire, M. M., additional, Zorrilla, M., additional, Bunce, K. D., additional, Peters, D., additional, Rajkovic, A., additional, Olszewska, M., additional, Kurpisz, M., additional, Gilbertson, A. Z. A., additional, Ottolini, C. S., additional, Summers, M. C., additional, Sage, K., additional, Handyside, A. H., additional, Thornhill, A. R., additional, Griffin, D. K., additional, Chung, M. K., additional, Kim, J. W., additional, Lee, J. H., additional, Jeong, H. J., additional, Kim, M. H., additional, Ryu, M. J., additional, Park, S. J., additional, Kang, H. Y., additional, Lee, H. S., additional, Zimmermann, B., additional, Banjevic, M., additional, Hill, M., additional, Lacroute, P., additional, Dodd, M., additional, Sigurjonsson, S., additional, Lau, P., additional, Prosen, D., additional, Chopra, N., additional, Ryan, A., additional, Hall, M., additional, McAdoo, S., additional, Demko, Z., additional, Levy, B., additional, Rabinowitz, M., additional, Vereczeky, A., additional, Kosa, Z. S., additional, Savay, S., additional, Csenki, M., additional, Nanassy, L., additional, Dudas, B., additional, Domotor, Z. S., additional, Debreceni, D., additional, Rossi, A., additional, Alegretti, J. R., additional, Cuzzi, J., additional, Bonavita, M., additional, Tanada, M., additional, Matunaga, P., additional, Fettback, P., additional, Rosa, M. B., additional, Maia, V., additional, Hassun, P., additional, Motta, E. L. A., additional, Piccolomini, M., additional, Gomes, C., additional, Barros, B., additional, Nicoliello, M., additional, Criscuolo, T., additional, Miyadahira, E., additional, Montjean, D., additional, Benkhalifa, M., additional, Berthaut, I., additional, Griveau, J. F., additional, Morcel, K., additional, Bashamboo, A., additional, McElreavey, K., additional, Ravel, C., additional, Rubio, C., additional, Rodrigo, L., additional, Mateu, E., additional, Mercader, A., additional, Peinado, V., additional, Buendia, P., additional, Milan, M., additional, Delgado, A., additional, Al-Asmar, N., additional, Escrich, L., additional, Campos-Galindo, I., additional, Garcia-Herrero, S., additional, Poo, M. E., additional, Mir, P., additional, Simon, C., additional, Reyes-Engel, A., additional, Cortes-Rodriguez, M., additional, Lendinez, A., additional, Perez-Nevot, B., additional, Palomares, A. R., additional, Galdon, M. R., additional, Ruberti, A., additional, Minasi, M. G., additional, Biricik, A., additional, Colasante, A., additional, Zavaglia, D., additional, Iammarrone, E., additional, Fiorentino, F., additional, Greco, E., additional, Demir, N., additional, Ozturk, S., additional, Sozen, B., additional, Morales, R., additional, Lledo, B., additional, Ortiz, J. A., additional, Ten, J., additional, Llacer, J., additional, Bernabeu, R., additional, Nagayoshi, M., additional, Tanaka, A., additional, Tanaka, I., additional, Kusunoki, H., additional, Watanabe, S., additional, Temel, S. G., additional, Beyazyurek, C., additional, Ekmekci, G. C., additional, Aybar, F., additional, Cinar, C., additional, Kahraman, S., additional, Nordqvist, S., additional, Karehed, K., additional, Akerud, H., additional, Gultomruk, M., additional, Tulay, P., additional, Findikli, N., additional, Yagmur, E., additional, Karlikaya, G., additional, Ulug, U., additional, Bahceci, M., additional, Bargallo, M. F., additional, Arevalo, M. R., additional, Salat, M. M., additional, Barbat, I. V., additional, Lopez, J. T., additional, Algam, M. E., additional, Boluda, A. B., additional, de Oya, G. C., additional, Tolmacheva, E. N., additional, Kashevarova, A. A., additional, Skryabin, N. A., additional, Lebedev, I. N., additional, Semaco, E., additional, Belo, A., additional, Riboldi, M., additional, Luz, L., additional, Nobrega, N., additional, Mazetto, R., additional, Alegretti, J. A., additional, Bibancos, M., additional, Serafini, P., additional, Neupane, J., additional, Vandewoestyne, M., additional, Heindryckx, B., additional, Deroo, T., additional, Lu, Y., additional, Ghimire, S., additional, Lierman, S., additional, Qian, C., additional, Deforce, D., additional, De Sutter, P., additional, Viloria, T., additional, Martinez-Jabaloyas, J. M., additional, Gil-Salom, M., additional, Capalbo, A., additional, Treff, N., additional, Cimadomo, D., additional, Tao, X., additional, Ferry, K., additional, Ubaldi, F. M., additional, Rienzi, L., additional, Scott, R. T., additional, Katzorke, N., additional, Vogt, H. P., additional, Hehr, A., additional, Gassner, C., additional, Paulmann, B., additional, Kowalzyk, Z., additional, Klatt, M., additional, Krauss, S., additional, Seifert, D., additional, Seifert, B., additional, Hehr, U., additional, Lobascio, M., additional, Varricchio, M. T., additional, Rubino, P., additional, Bono, S., additional, Cotarelo, R. P., additional, Spizzichino, L., additional, Colicchia, A., additional, Giannini, P., additional, Suhorutshenko, M., additional, and Rosenstein-Tamm, K., additional

Published
2013
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6. SELECTED ORAL COMMUNICATION SESSION, SESSION 25: TRANSLATIONAL RESEARCH, Monday 4 July 2011 17:00 - 18:00

Author

Ben-Ami, I., primary, Chuderland, D., additional, Kaplan-Kraicer, R., additional, Grossman, H., additional, Ron-El, R., additional, Shalgi, R., additional, Huszar, G., additional, Geerts, N., additional, Vanderlick, K., additional, McGrath, J., additional, Alegretti, J., additional, Motta, E. L. A., additional, Serafini, P., additional, Rocha, A. M., additional, Criscuolo, T., additional, Smith, G. D., additional, Liebenthron, J., additional, Montag, M., additional, Koster, M., additional, van der Ven, K., additional, and van der Ven, H., additional

Published
2011
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9. Impaired glucose oxidation and glucose-induced thermogenesis in renal transplant recipients.

Author

de Pascale, E, Giordano, M, Carone, M, Pluvio, C, Pluvio, M, Criscuolo, T, Infantone, L, and Castellino, P

Abstract

Renal transplant recipients often show various metabolic abnormalities including reduced glucose tolerance, impaired insulin sensitivity and altered lipid metabolism. However, the acute effects of carbohydrate ingestion on substrate utilization and energy expenditure have not been fully elucidated.

Published
2000
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10. Impaired glucose oxidation and glucose-induced thermogenesis in renal transplant recipients

Author

Lorena Infantone, M. Pluvio, Mauro Giordano, Emanuela de Pascale, Tullio Criscuolo, Pietro Castellino, C. Pluvio, M. Carone, DE PASCALE, E, Giordano, Mauro, Carone, M, Pluvio, C, Pluvio, M, Criscuolo, T, Infantone, L, and Castellino, P.

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Anti-Inflammatory Agents, Administration, Oral, Carbohydrate metabolism, Glomerulonephritis, Lipid oxidation, Reference Values, Internal medicine, medicine, Humans, Insulin, Transplantation, business.industry, Metabolic disorder, Calorimetry, Indirect, Thermogenesis, Carbohydrate, Lipid Metabolism, medicine.disease, Kidney Transplantation, Glucose, Endocrinology, Basal (medicine), Nephrology, Basal metabolic rate, Carbohydrate Metabolism, Prednisone, Drug Therapy, Combination, Female, Energy Metabolism, business, Oxidation-Reduction, Immunosuppressive Agents
Abstract

Background. Renal transplant recipients often show various metabolic abnormalities including reduced glucose tolerance, impaired insulin sensitivity and altered lipid metabolism. However, the acute effects of carbohydrate ingestion on substrate utilization and energy expenditure have not been fully elucidated. Methods. We evaluated: (i) basal energy expenditure (EE) and substrate utilization, (ii) metabolic fate of an oral glucose load, and (iii) substrate-induced thermogenesis in: (a) 15 non-diabetic renal transplant recipients (Tx) (BMI 25 ± 1) on triple immunosuppressive therapy, (b) 11 patients with primary glomerulonephritis (BMI 25 ± 1) (Cort) receiving prednisone treatment, and (c) 12 healthy subjects (BMI 26 ± 1) (N). Continuous indirect calorimetry was performed in the basal post-absorptive state for 60 min and continued for an additional 180 min following an oral glucose load (75 g). Results. In the basal state, EE was similar in the three study groups. It averaged 14.6 ± 0.7, 15.7 ± 1.3, and 14.1 ± 0.8 cal/kg/min in Tx, Cort, and N respectively. Glucose oxidation was higher in N (1.3 ± 0.2 mg/kg/min) than in Tx (0.7 ± 0.2) and Cort (1.0 ± 0.2) (P

Published
2000

11. Bioactivity of prolactin in systemic sclerosis.

Author

La Montagna G, Meli R, Criscuolo T, D'Angelo S, and Valentini G

Subjects
Adolescent, Adult, Aged, Blood Sedimentation, C-Reactive Protein analysis, Cell Division, Cell Line, Tumor, Female, Humans, Intercellular Adhesion Molecule-1 blood, Male, Middle Aged, Peptide Fragments blood, Procollagen blood, Receptors, Interleukin-2 blood, Scleroderma, Systemic pathology, Scleroderma, Systemic physiopathology, Severity of Illness Index, Skin pathology, von Willebrand Factor analysis, Prolactin blood, Scleroderma, Systemic blood
Abstract

Objectives: To evaluate basal serum prolactin (PRL) levels in systemic sclerosis (SSc) patients with different degrees of skin involvement, and investigate its relationship with some of the clinical and serological parameters of the disease., Methods: Basal serum PRL was measured in 44 SSc patients (38 F, 6 M) using a rat NB2 lymphoma line cell proliferation assay. Other parameters measured were: serum aminoterminal propeptide of type III procollagen (PIIINP) by RIA; soluble alpha interleukin-2 receptor (IL-2 sRalpha), serum intercellular adhesion molecule-1 (ICAM-1), von Willebrand factor (vWF) by ELISA; the erythrocyte sedimentation rate (ESR); and C-reactive protein (CRP). Skin and organ/system involvement were assessed according to Medsger et al.'s organ/system severity scale, and global disease activity index according to Valentini et al., Results: The serum PRL concentration in the SSc patients was 13.8 ng/ml (95%CI from 3.2 to 49.1 ng/ml), similar than that in control subjects (12.8 ng/nl: 95%CI 3.0 to 18.4 ng/ml). Hyperprolactinemia, defined as a level > 20 ng/ml (mean 30.9 ng/ml, median 29.3) was found in a total of 6 cases (13.6%; 95%CI 5.8 to 28%) cases: in 1 out of 6 men (16.7%; 95%CI -26% to 59%) and similarly in 5/38 women (13.2%; 95%CI 1.9% to 24.4%). No correlation was found between PRL levels and SSc subgroup (lcSSc, icSSc, dcSSc), serologial parameters, or the level of disease activity. Finally, no significant correlations were found with clinical or serological variables., Conclusions: The findings confirm that mild hyperprolactinemia occurs in at subgroup of SSc patients. However, prospective studies are needed to better define the relationship between PRL and disease activity in scleroderma.

Published
2004

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