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1. Spectroscopy of deeply bound orbitals in neutron-rich Ca isotopes

Author

P.J. Li, J. Lee, P. Doornenbal, S. Chen, S. Wang, A. Obertelli, Y. Chazono, J.D. Holt, B.S. Hu, K. Ogata, Y. Utsuno, K. Yoshida, N.L. Achouri, H. Baba, F. Browne, D. Calvet, F. Château, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, H.N. Liu, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, K. Boretzky, C. Caesar, L.X. Chung, F. Flavigny, S. Franchoo, I. Gasparic, R.-B. Gerst, J. Gibelin, K.I. Hahn, J. Kahlbow, D. Kim, T. Koiwai, Y. Kondo, D. Körper, P. Koseoglou, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Miki, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, F. Schindler, H. Simon, P.-A. Söderström, D. Sohler, S. Takeuchi, H. Toernqvist, J. Tscheuschner, V. Vaquero, V. Wagner, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Unbound states, Knockout reaction, Single-particle strength, Shell evolution, Physics, QC1-999
Abstract

The calcium isotopes are an ideal system to investigate the evolution of shell structure and magic numbers. Although the properties of surface nucleons in calcium have been well studied, probing the structure of deeply bound nucleons remains a challenge. Here, we report on the first measurement of unbound states in 53Ca and 55Ca, populated from 54,56Ca(p,pn) reactions at a beam energy of around 216 MeV/nucleon at the RIKEN Radioactive Isotopes Beam Factory. The resonance properties, partial cross sections, and momentum distributions of these unbound states were analyzed. Orbital angular momentum l assignments were extracted from momentum distributions based on calculations using the distorted wave impulse approximation (DWIA) reaction model. The resonances at excitation energies of 5516(41)keV in 53Ca and 6000(250)keV in 55Ca indicate a significant l =3 component, providing the first experimental evidence for the ν0f7/2 single-particle strength of unbound hole states in the neutron-rich Ca isotopes. The observed excitation energies and cross-sections point towards extremely localized and well separated strength distributions, with some fragmentation for the ν0f7/2 orbital in 55Ca. These results are in good agreement with predictions from shell-model calculations using the effective GXPF1Bs interaction and ab initio calculations and diverge markedly from the experimental distributions in the nickel isotones at Z=28.

Published
2024
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2. Level structures of 56,58Ca cast doubt on a doubly magic 60Ca

Author

S. Chen, F. Browne, P. Doornenbal, J. Lee, A. Obertelli, Y. Tsunoda, T. Otsuka, Y. Chazono, G. Hagen, J.D. Holt, G.R. Jansen, K. Ogata, N. Shimizu, Y. Utsuno, K. Yoshida, N.L. Achouri, H. Baba, D. Calvet, F. Château, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, H.N. Liu, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, L.X. Chung, F. Flavigny, S. Franchoo, I. Gasparic, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, T. Koiwai, Y. Kondo, P. Koseoglou, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, P.-A. Söderström, D. Sohler, S. Takeuchi, H. Törnqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Shell evolution, γ Ray spectroscopy, Physics, QC1-999
Abstract

Gamma decays were observed in 56Ca and 58Ca following quasi-free one-proton knockout reactions from 57,59Sc beams at ≈200 MeV/nucleon. For 56Ca, a γ ray transition was measured to be 1456(12) keV, while for 58Ca an indication for a transition was observed at 1115(34) keV. Both transitions were tentatively assigned as the 21+→0gs+ decays, and were compared to results from ab initio and conventional shell-model approaches. A shell-model calculation in a wide model space with a marginally modified effective nucleon-nucleon interaction depicts excellent agreement with experiment for 21+ level energies, two-neutron separation energies, and reaction cross sections, corroborating the formation of a new nuclear shell above the N = 34 shell. Its constituents, the 0f5/2 and 0g9/2 orbitals, are almost degenerate. This degeneracy precludes the possibility for a doubly magic 60Ca and potentially drives the dripline of Ca isotopes to 70Ca or even beyond.

Published
2023
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3. A first glimpse at the shell structure beyond 54Ca: Spectroscopy of 55K, 55Ca, and 57Ca

Author

T. Koiwai, K. Wimmer, P. Doornenbal, A. Obertelli, C. Barbieri, T. Duguet, J.D. Holt, T. Miyagi, P. Navrátil, K. Ogata, N. Shimizu, V. Somà, Y. Utsuno, K. Yoshida, N.L. Achouri, H. Baba, F. Browne, D. Calvet, F. Château, S. Chen, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, H.N. Liu, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Yoneda, O. Aktas, T. Aumann, L.X. Chung, F. Flavigny, S. Franchoo, I. Gasparic, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, Y. Kondo, P. Koseoglou, J. Lee, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, P.-A. Söderström, D. Sohler, S. Takeuchi, H. Toernqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Radioactive beams, γ-ray spectroscopy, Shell evolution, Physics, QC1-999
Abstract

States in the N=35 and 37 isotopes 55,57Ca have been populated by direct proton-induced nucleon removal reactions from 56,58Sc and 56Ca beams at the RIBF. In addition, the (p,2p) quasi-free single-proton removal reaction from 56Ca was studied. Excited states in 55K, 55Ca, and 57Ca were established for the first time via in-beam γ-ray spectroscopy. Results for the proton and neutron removal reactions from 56Ca to states in 55K and 55Ca for the level energies, excited state lifetimes, and exclusive cross sections agree well with state-of-the-art theoretical calculations using different approaches. The observation of a short-lived state in 57Ca suggests a transition in the calcium isotopic chain from single-particle dominated states at N=35 to collective excitations at N=37.

Published
2022
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4. First spectroscopic study of 51Ar by the (p,2p) reaction

Author

M.M. Juhász, Z. Elekes, D. Sohler, Y. Utsuno, K. Yoshida, T. Otsuka, K. Ogata, P. Doornenbal, A. Obertelli, H. Baba, F. Browne, D. Calvet, F. Château, S. Chen, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, N.L. Achouri, O. Aktas, T. Aumann, L.X. Chung, Zs. Dombrádi, F. Flavigny, S. Franchoo, I. Gašparić, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, T. Koiwai, Y. Kondo, P. Koseoglou, J. Lee, C. Lehr, B.D. Linh, H.N. Liu, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, P.-A. Söderström, S. Takeuchi, H. Törnqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Proton knock-out reaction, γ-ray spectroscopy, Invariant mass method, Nuclear structure, Shell closure, Physics, QC1-999
Abstract

The nuclear structure of 51Ar, an uncharted territory so far, was studied by the (p,2p) reaction using γ-ray spectroscopy for the bound states and the invariant mass method for the unbound states. Two peaks were detected in the γ-ray spectrum and six peaks were observed in the 50Ar+n relative energy spectrum. Comparing the results to our shell-model calculations, two bound and six unbound states were established. Three of the unbound states could only be placed tentatively due to the low number of counts in the relative energy spectrum of events associated with the decay through the first excited state of 50Ar. The low cross sections populating the two bound states of 51Ar could be interpreted as a clear signature for the presence of significant subshell closures at neutron numbers 32 and 34 in argon isotopes. It was also revealed that due to the two valence holes, unbound collective states coexist with individual-particle states in 51Ar.

Published
2021
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5. Restoration of the natural E(1/21+) - E(3/21+) energy splitting in odd-K isotopes towards N = 40

Author

Y.L. Sun, A. Obertelli, P. Doornenbal, C. Barbieri, Y. Chazono, T. Duguet, H.N. Liu, P. Navrátil, F. Nowacki, K. Ogata, T. Otsuka, F. Raimondi, V. Somà, Y. Utsuno, K. Yoshida, N. Achouri, H. Baba, F. Browne, D. Calvet, F. Château, S. Chen, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, L.X. Chung, F. Flavigny, S. Franchoo, I. Gašparić, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, T. Koiwai, Y. Kondo, P. Koseoglou, J. Lee, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, D. Sohler, P.-A. Söderström, S. Takeuchi, H. Törnqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Physics, QC1-999
Abstract

We report on the first γ-ray spectroscopy of 51,53K produced via the 52,54Ca(p,2p) reactions at ∼250 MeV/nucleon. Unambiguous final-state angular-momentum assignments were achieved for beam intensities down to few particles per second by using a new technique based on reaction vertex tracking combined with a thick liquid-hydrogen target. Through γ-ray spectroscopy and exclusive parallel momentum distribution analysis, 3/2+ ground states and 1/2+ first excited states in 51,53K were established quantifying the natural ordering of the 1d3/2 and 2s1/2 proton-hole states that are restored at N = 32 and 34. State-of-the-art ab initio calculations and shell-model calculations with improved phenomenological effective interactions reproduce the present data and predict consistently the increase of the E(1/21+) - E(3/21+) energy differences towards N = 40. Keywords: Spectroscopy, Shell evolution, 51K, 53K

Published
2020
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6. Shell evolution of N = 40 isotones towards 60Ca: First spectroscopy of 62Ti

Author

M.L. Cortés, W. Rodriguez, P. Doornenbal, A. Obertelli, J.D. Holt, S.M. Lenzi, J. Menéndez, F. Nowacki, K. Ogata, A. Poves, T.R. Rodríguez, A. Schwenk, J. Simonis, S.R. Stroberg, K. Yoshida, L. Achouri, H. Baba, F. Browne, D. Calvet, F. Château, S. Chen, N. Chiga, A. Corsi, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, H.N. Liu, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, L.X. Chung, F. Flavigny, S. Franchoo, I. Gašparić, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, T. Koiwai, Y. Kondo, P. Koseoglou, J. Lee, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, D. Sohler, P.-A. Söderström, S. Takeuchi, H. Toernqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
Physics, QC1-999
Abstract

Excited states in the N=40 isotone 62Ti were populated via the 63V(p,2p)62Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using γ-ray spectroscopy. The energies of the 21+→0gs+ and 41+→21+ transitions, observed here for the first time, indicate a deformed 62Ti ground state. These energies are increased compared to the neighboring 64Cr and 66Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for 62Ti show a dominant configuration with four neutrons excited across the N=40 gap. Likewise, they indicate that the N=40 island of inversion extends down to Z=20, disfavoring a possible doubly magic character of the elusive 60Ca. Keywords: Shell evolution, Radioactive beams, Gamma-ray spectroscopy

Published
2020
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7. Extended p3/2 Neutron Orbital and the N=32 Shell Closure in Ca52

Author

M. Enciu, H. N. Liu, A. Obertelli, P. Doornenbal, F. Nowacki, K. Ogata, A. Poves, K. Yoshida, N. L. Achouri, H. Baba, F. Browne, D. Calvet, F. Château, S. Chen, N. Chiga, A. Corsi, M. L. Cortés, A. Delbart, J-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y. L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, L. X. Chung, F. Flavigny, S. Franchoo, I. Gasparic, R.-B. Gerst, J. Gibelin, K. I. Hahn, D. Kim, Y. Kondo, P. Koseoglou, J. Lee, C. Lehr, P. J. Li, B. D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S. Y. Park, D. Rossi, E. Sahin, P.-A. Söderström, D. Sohler, S. Takeuchi, H. Toernqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, and L. Zanetti

Subjects
General Physics and Astronomy
Published
2022
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9. Investigation of the ground-state spin inversion in the neutron-rich Cl47,49 isotopes

Author

Jason D. Holt, Carlo Barbieri, Zaihong Yang, I. Murray, D. M. Rossi, K. I. Hahn, S. Y. Park, C. Hilaire, Kazuyuki Ogata, C. Lehr, H. Baba, Duo Yan, David Steppenbeck, H. Törnqvist, P. Koseoglou, Masahiro Yasuda, V. Lapoux, Yasuhiro Togano, N. L. Achouri, R.-B. Gerst, Alessandra Corsi, T. Lokotko, B. D. Linh, L. Stuhl, H. Wang, Dóra Sohler, M. Gómez-Ramos, Igor Gašparić, H. N. Liu, Y. L. Sun, Takashi Nakamura, E. Sahin, Petr Navrátil, V. Panin, W. Rodriguez, N. Shimizu, J. M. Gheller, A. Moro, Victor Vaquero, L. X. Chung, Thomas Duguet, K. Moschner, Hiroyoshi Sakurai, Kathrin Wimmer, Dong-Wook Kim, A. Delbart, N. T. Khai, V. Wagner, N. Paul, P. Doornenbal, T. Motobayashi, V. Somà, D. Calvet, T. Isobe, K. Yoneda, O. Aktas, V. Werner, Y. Yamada, Thomas Aumann, F. Flavigny, N. D. Ton, T. Kobayashi, A. Giganon, X. X. Xu, F. Château, Hideaki Otsu, Julien Gibelin, Si-Ge Chen, N. T. T. Phuc, P. A. Söderström, A. Gillibert, Nobuyuki Chiga, A. Obertelli, T. Koiwai, Tomohiro Uesaka, F. Browne, M. MacCormick, Satoshi Takeuchi, M. L. Cortés, Masaki Sasano, S. Franchoo, Yutaka Utsuno, Jenny Lee, Yuya Kubota, L. Zanetti, and Yosuke Kondo

Subjects
Physics, Isotope, 010308 nuclear & particles physics, 0103 physical sciences, Neutron, Atomic physics, 010306 general physics, Spin (physics), Ground state, 01 natural sciences, Inversion (discrete mathematics), Nuclear theory
Published
2021
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10. Pairing Forces Govern Population of Doubly Magic Ca54 from Direct Reactions

Author

J. M. Gheller, S. Y. Park, K. Yoneda, Masaki Sasano, P. A. Söderström, D. Sohler, D. Körper, H. Simon, A. Gillibert, K. Miki, Satoshi Takeuchi, Yasuhiro Togano, M. MacCormick, R.-B. Gerst, Duo Yan, Tomohiro Uesaka, Fabia Schindler, V. Wagner, B. D. Linh, M. Holl, A. Corsi, N. Paul, Igor Gašparić, H. N. Liu, P. Koseoglou, E. Sahin, Yosuke Kondo, T. Lokotko, T. Isobe, Victor Vaquero, M. L. Cortés, V. Werner, Takashi Nakamura, W. Rodriguez, Zaihong Yang, A. Delbart, S. Franchoo, F. Château, V. Lapoux, P. Doornenbal, K. I. Hahn, L. Stuhl, I. Murray, C. Caesar, Kazuyuki Ogata, C. Lehr, T. Kobayashi, X. X. Xu, C. Hilaire, Si-Ge Chen, Yutaka Utsuno, V. Panin, A. Giganon, Jenny Lee, N. L. Achouri, L. X. Chung, Y. L. Sun, K. Moschner, Yuya Kubota, D. M. Rossi, H. Baba, F. Flavigny, Masahiro Yasuda, L. Zanetti, Kathrin Wimmer, Dong-Wook Kim, O. Aktas, F. Browne, S. Wang, A. Obertelli, J. Kahlbow, Hiroyoshi Sakurai, T. Motobayashi, Julien Gibelin, K. Boretzky, D. Calvet, David Steppenbeck, H. Törnqvist, Thomas Aumann, Nobuyuki Chiga, T. Koiwai, Kazuki Yoshida, Hideaki Otsu, Hirofumi Yamada, and J. Tscheuschner

Subjects
Physics, education.field_of_study, Proton, 010308 nuclear & particles physics, Nuclear Theory, Population, Nuclear shell model, General Physics and Astronomy, 01 natural sciences, 7. Clean energy, Pairing, Excited state, 0103 physical sciences, Neutron, Atomic physics, Nuclear Experiment, 010306 general physics, Nucleon, Ground state, education
Abstract

Direct proton-knockout reactions of ^{55}Sc at ∼220 MeV/nucleon were studied at the RIKEN Radioactive Isotope Beam Factory. Populated states of ^{54}Ca were investigated through γ-ray and invariant-mass spectroscopy. Level energies were calculated from the nuclear shell model employing a phenomenological internucleon interaction. Theoretical cross sections to states were calculated from distorted-wave impulse approximation estimates multiplied by the shell model spectroscopic factors, which describe the wave function overlap of the ^{55}Sc ground state with states in ^{54}Ca. Despite the calculations showing a significant amplitude of excited neutron configurations in the ground-state of ^{55}Sc, valence proton removals populated predominantly the ground state of ^{54}Ca. This counterintuitive result is attributed to pairing effects leading to a dominance of the ground-state spectroscopic factor. Owing to the ubiquity of the pairing interaction, this argument should be generally applicable to direct knockout reactions from odd-even to even-even nuclei.

Published
2021
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11. First spectroscopic study of V63 at the N=40 island of inversion

Author

K. Moschner, David Steppenbeck, F. Browne, Jenny Lee, H. Törnqvist, Y. L. Sun, Kathrin Wimmer, Yuya Kubota, A. Gillibert, V. Panin, E. Sahin, L. X. Chung, D. Calvet, T. Isobe, Alessandra Corsi, Dóra Sohler, R.-B. Gerst, M. MacCormick, Yosuke Kondo, F. Château, Hideaki Otsu, P. Doornenbal, Hirofumi Yamada, N. Paul, V. Werner, Satoshi Takeuchi, M. L. Cortés, Masahiro Yasuda, D. M. Rossi, S. Franchoo, C. Lehr, W. Rodriguez, H. Baba, S. Y. Park, Z. Elekes, A. Giganon, Kazuyuki Ogata, Nobuyuki Chiga, Duo Yan, T. Lokotko, L. Zanetti, L. Stuhl, K. Yoneda, T. Koiwai, Takashi Nakamura, A. Delbart, Masaki Sasano, N. L. Achouri, S. Wang, B. D. Linh, Igor Gašparić, H. N. Liu, Yasuhiro Togano, V. Wagner, P. Koseoglou, F. Flavigny, J. M. Gheller, Tomohiro Uesaka, A. Obertelli, Zs. Dombrádi, Hiroyoshi Sakurai, T. Motobayashi, Julien Gibelin, Dong-Wook Kim, O. Aktas, V. Lapoux, K. Yoshida, M. M. Juhász, Kamila Sieja, Zaihong Yang, I. Murray, K. I. Hahn, T. Kobayashi, X. X. Xu, Si-Ge Chen, P. A. Söderström, Victor Vaquero, Thomas Aumann, and C. Hilaire

Subjects
Physics, 010308 nuclear & particles physics, Island of inversion, 0103 physical sciences, Geophysics, 010306 general physics, 01 natural sciences
Published
2021
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12. First spectroscopic study of $^{51}$Ar by the (p,2p) reaction

Author

Zs. Dombradi, S. Y. Park, T. Isobe, F. Browne, K. Moschner, Thomas Aumann, R.-B. Gerst, F. Château, Kathrin Wimmer, X. X. Xu, Z. Elekes, L. Zanetti, Hideaki Otsu, B. D. Linh, Hirofumi Yamada, Si-Ge Chen, P. A. Söderström, Yutaka Utsuno, Igor Gašparić, H. N. Liu, Jenny Lee, Zaihong Yang, I. Murray, Yasuhiro Togano, F. Flavigny, K. I. Hahn, L. Stuhl, Yuya Kubota, V. Wagner, Tomohiro Uesaka, A. Giganon, D. Kim, M. MacCormick, C. Lehr, V. Panin, L. X. Chung, P. Koseoglou, T. Lokotko, Y.L. Sun, E. Sahin, K. Yoneda, Victor Vaquero, M. L. Cortés, Takashi Nakamura, S. Franchoo, P. Doornenbal, Satoshi Takeuchi, Masahiro Yasuda, O. Aktas, A. Gillibert, V. Lapoux, Nobuyuki Chiga, Takaharu Otsuka, T. Koiwai, Hiroyoshi Sakurai, T. Motobayashi, M. M. Juhász, Kazuki Yoshida, David Steppenbeck, Julien Gibelin, H. Törnqvist, Toshio Kobayashi, Kazuyuki Ogata, W. Rodriguez, N. L. Achouri, C. Hilaire, S. Wang, Donghang Yan, N. Paul, A. Obertelli, J. M. Gheller, Yosuke Kondo, V. Werner, D. Calvet, D. M. Rossi, Masaki Sasano, H. Baba, D. Sohler, A. Corsi, A. Delbart, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), RIKEN Nishina Center for Accelerator-Based Science, European Research Council, European Commission, Helmholtz International Center for FAIR, German Research Foundation, Alexander von Humboldt Foundation, Ministry of Science and Technology of Vietnam, Government of South Korea, Agencia Estatal de Investigación (España), Federal Ministry of Education and Research (Germany), Helmholtz Graduate School for Hadron and Ion Research, and National Research, Development and Innovation Office (Hungary)

Subjects
Nuclear and High Energy Physics, Shell closure, γ -ray spectroscopy, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 0103 physical sciences, Bound state, nuclear shell model, proton knock-out reaction, gamma-ray spectroscopy, invariant-mass method, radioactive beams, Invariant mass, Neutron, ddc:530, Nuclear structure, 010306 general physics, Spectroscopy, Physics, Valence (chemistry), Proton knock-out reaction, 010308 nuclear & particles physics, Invariant mass method, Isotopes of argon, lcsh:QC1-999, Excited state, γ-ray spectroscopy, Atomic physics, lcsh:Physics
Abstract

8 pags., 4 figs., 3 tabs., The nuclear structure of 51Ar, an uncharted territory so far, was studied by the (p,2p) reaction using γ-ray spectroscopy for the bound states and the invariant mass method for the unbound states. Two peaks were detected in the γ-ray spectrum and six peaks were observed in the 50Ar+n relative energy spectrum. Comparing the results to our shell-model calculations, two bound and six unbound states were established. Three of the unbound states could only be placed tentatively due to the low number of counts in the relative energy spectrum of events associated with the decay through the first excited state of 50Ar. The low cross sections populating the two bound states of 51Ar could be interpreted as a clear signature for the presence of significant subshell closures at neutron numbers 32 and 34 in argon isotopes. It was also revealed that due to the two valence holes, unbound collective states coexist with individual-particle states in 51Ar., We are very grateful to the RIKEN Nishina Center accelerator staff for providing the stable beam and to the BigRIPS team for the smooth operation of the secondary beams. The development of the MINOS device has been supported by the European Research Council through the ERC Grant No. MINOS-258567. F. B. was supported by the RIKEN Special Postdoctoral Researcher Program. K. O. acknowledges the support by Grant-in-Aid for Scientific Research JP16K05352. Y. U. acknowledges the support by Grant-in-Aid for Scientific Research 20K03981. Y. L. S. acknowledges the support of Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2015-705023) from the European Union and the support from the Helmholtz International Center for FAIR. H. N. L. acknowledges the support from the Enhanced Eurotalents program (PCOFUND-GA-2013-600382) co-funded by CEA and the European Union. T. A., C. L., D. R., H. T., V. W., L. Z., H. N. L., V. W. and A. O. acknowledge the support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Project No. 279384907-SFB 1245. R. B. G. acknowledges the support from the DFG under Grant No. BL 1513/1-1. Y. L. S. and A. O. acknowledge the support from the Alexander von Humboldt Foundation. B. D. L. and L. X. C. acknowledge the support from the Vietnam Ministry of Science and Technology under Grant No. ĐTCB.01/21/VKHKTHN. I. G. has been supported by HIC for FAIR and HRZZ under project No. 1257 and 7194. K. I. H., D. K. and S. Y. P. acknowledge the support from the NRF grant funded by the Korea government (No. 2017R1A2B2012382 and 2019M7A1A1033186). F. B. acknowledge the support from the RIKEN Special Postdoctoral Researcher Program. D. S. and Z. E. were supported by projects No. GINOP-2.3.3-15-2016-00034 and No. K128947. V. V. acknowledges support from the Spanish Ministerio de Economía y Competitividad under Contract No. FPA2017-84756-C4-2-P. V. W. and P. K. acknowledge the support from BMBF grants 05P15RDFN1 and 05P19RDFN1. P. K. acknowledges support from HGS-HIRe. This work was also supported by NKFIH (114454).

Published
2021
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13. N=32 shell closure below calcium: Low-lying structure of Ar50

Author

Nobuyuki Chiga, K. Moschner, T. Koiwai, Hiroyoshi Sakurai, V. Lapoux, A. Gillibert, Yutaka Utsuno, D. Calvet, T. Isobe, Kathrin Wimmer, T. Motobayashi, Jenny Lee, Achim Schwenk, H. Toernqvist, Yuya Kubota, Victor Vaquero, R.-B. Gerst, F. Château, W. Rodriguez, N. Shimizu, B. D. Linh, D. M. Rossi, Masahiro Yasuda, Tomohiro Uesaka, Hideaki Otsu, Igor Gašparić, H. N. Liu, V. Panin, H. Baba, Kazuyuki Ogata, L. X. Chung, S. Y. Park, Julien Gibelin, Hirofumi Yamada, K. Yoshida, C. Lehr, Duo Yan, L. Achouri, Zaihong Yang, L. Stuhl, A. Giganon, I. Murray, S. Wang, N. Paul, L. Zanetti, E. Sahin, Y. L. Sun, J. Simonis, A. Obertelli, K. Yoneda, C. Hilaire, K. I. Hahn, V. Werner, David Steppenbeck, Jason D. Holt, P. Doornenbal, A. Delbart, M. MacCormick, P. Koseoglou, J. M. Gheller, Alessandra Corsi, Thomas Aumann, Masaki Sasano, Dóra Sohler, Satoshi Takeuchi, M. L. Cortés, S. Franchoo, T. Kobayashi, F. Flavigny, X. X. Xu, Si-Ge Chen, P. A. Söderström, Dong-Wook Kim, F. Browne, O. Aktas, Yosuke Kondo, Yasuhiro Togano, T. Lokotko, Takashi Nakamura, Javier Fernandez Menendez, and V. Wagner

Subjects
Physics, 010308 nuclear & particles physics, 0103 physical sciences, Closure (topology), Shell (structure), Calcium low, 010306 general physics, 01 natural sciences, Molecular physics
Published
2020
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14. Shell evolution of $N=40$ isotones towards $^{60}$Ca: First spectroscopy of $^{62}$Ti

Author

Masaki Sasano, S. M. Lenzi, Kazuki Yoshida, E. Sahin, V. Wagner, Hiroyoshi Sakurai, F. Nowacki, T. Isobe, W. Rodriguez, P. Doornenbal, Donghang Yan, D. Kim, T. Motobayashi, M.L. Cortés, Jason D. Holt, V. Lapoux, D. M. Rossi, Toshio Kobayashi, F. Flavigny, A. Giganon, B. D. Linh, F. Château, V. Panin, H. Baba, N. Paul, L. X. Chung, D. Calvet, X. X. Xu, David Steppenbeck, V. Werner, Igor Gašparić, H. N. Liu, A. Delbart, Yosuke Kondo, Si-Ge Chen, L. Achouri, Julien Gibelin, Tomohiro Uesaka, J. M. Gheller, A. Corsi, S. R. Stroberg, Alfredo Poves, Achim Schwenk, Satoshi Takeuchi, Thomas Aumann, R.-B. Gerst, C. Lehr, Jenny Lee, Yasuhiro Togano, C. Hilaire, Y.L. Sun, P. Koseoglou, Nobuyuki Chiga, K. Yoneda, F. Browne, Victor Vaquero, Yuya Kubota, T. Lokotko, T. Koiwai, Zaihong Yang, Takashi Nakamura, S. Wang, J. Simonis, I. Murray, Javier Fernandez Menendez, A. Obertelli, Kazuyuki Ogata, A. Gillibert, H. Toernqvist, M. MacCormick, Masahiro Yasuda, Hideaki Otsu, K. I. Hahn, L. Stuhl, O. Aktas, Hirofumi Yamada, Dóra Sohler, S. Franchoo, Tomás R. Rodríguez, L. Zanetti, K. Moschner, Kathrin Wimmer, S. Y. Park, P. A. Söderström, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), UAM. Departamento de Física Teórica, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), RIKEN Nishina Center for Accelerator-Based Science, Japan Society for the Promotion of Science, Ministerio de Ciencia, Innovación y Universidades (España), Ministry of Science and Technology of Vietnam, Helmholtz International Center for FAIR, Croatian Science Foundation, National Research, Development and Innovation Office (Hungary), Ministerio de Economía y Competitividad (España), National Research Foundation of Korea, European Commission, Natural Sciences and Engineering Research Council of Canada, Federal Ministry of Education and Research (Germany), and National Research Council of Canada

Subjects
Nuclear and High Energy Physics, Nuclear Theory, Ab initio, FOS: Physical sciences, Shell evolution, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Radioactive beams, Gamma-ray spectroscopy, Nuclear Theory (nucl-th), 0103 physical sciences, ddc:530, Nuclear Experiment (nucl-ex), 010306 general physics, Spectroscopy, Nuclear Experiment, Physics, 010308 nuclear & particles physics, Island of inversion, Isotone, Starke Wechselwirkung und exotische Kerne – Abteilung Blaum, Física, lcsh:QC1-999, Excited state, Quadrupole, Atomic physics, Nucleon, Ground state, lcsh:Physics
Abstract

7 pags., 4 figs., 1 tab., Excited states in the N=40 isotone Ti were populated via the V(p,2p)Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using γ-ray spectroscopy. The energies of the 2 →0 and 4 →2 transitions, observed here for the first time, indicate a deformed Ti ground state. These energies are increased compared to the neighboring Cr and Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for Ti show a dominant configuration with four neutrons excited across the N=40 gap. Likewise, they indicate that the N=40 island of inversion extends down to Z=20, disfavoring a possible doubly magic character of the elusive Ca., We thank the RIKEN Nishina Center accelerator staff and the Bi-gRIPS team for the stable operation of the high-intensity Zn beam and for the preparation of the secondary beam setting. K.O. ac-knowledges the support by Grant-in-Aid for Scientific Research of the Japan Society for the Promotion of Science (JSPS) JP16K05352. A.P. is supported in part by the Ministerio de Ciencia, Innovación y Universidades (Spain), Severo Ochoa Programme SEV-2016-0597 and grant PGC-2018-94583. F.B. is supported by the RIKEN Spe-cial Postdoctoral Researcher Program. L.X.C. and B.D.L. would like to thank the Vietnam Ministry of Science and Technology (MOST) for its support through the Physics Development Program Grant No. ÐTÐLCN.25/18. I.G. has been supported by HIC for FAIR and Croatian Science Foundation under projects no. 1257 and 7194. D. So. was supported by the the European Regional Develop-ment Fund contract No. GINOP-2.3.3-15-2016-00034 and the National Research, Development and Innovation Fund of Hungary via Project No. K128947. V.V. acknowledges support from the Span-ish Ministerio de Economía y Competitividad under Contract No. FPA2017-84756-C4-2-P. K.I.H., D.K. and S.Y.P. acknowledge the sup-port from the National Research Foundation of Korea grant No. 2018R1A5A1025563 and 2019M7A1A1033186. The development of MINOS was supported by the European Research Council through the ERC Grant No. MINOS-258567. This work was also supported by the JSPS KAKENHI Grant No. 18K03639, MEXT as “Priority is-sue on post-K computer” (Elucidation of the fundamental laws and evolution of the universe), the Joint Institute for Computational Fundamental Science (JICFuS), the CNS-RIKEN joint project for large-scale nuclear structure calculations, Natural Sciences and Engineering Research Council (NSERC) of Canada, the Deutsche Forschungsgemeinschaft – Projektnummer 279384907 – SFB 1245, the PRISMA Cluster of Excellence, and the BMBF under Contracts No. 05P18RDFN1 and 05P19RDFN1. TRIUMF receives funding via a contribution through the National Research Council Canada. Com-putations were performed at the Jülich Supercomputing Center (JURECA)

Published
2020
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15. Quasifree Neutron Knockout from Ca54 Corroborates Arising N=34 Neutron Magic Number

Author

V. Wagner, V. Somà, F. Flavigny, K. Moschner, S. Y. Park, V. Panin, Kathrin Wimmer, M. MacCormick, S. Takeuchi, M. L. Cortés, S. Franchoo, Hideaki Otsu, D. Calvet, D. M. Rossi, Toshio Kobayashi, K. Yoneda, Tomohiro Uesaka, Masaki Sasano, T. Lokotko, P. Koseoglou, Dóra Sohler, H. Baba, N. Paul, P. A. Söderström, David Steppenbeck, Nobuyuki Chiga, E. Sahin, Petr Navrátil, Thomas Aumann, Takashi Nakamura, F. Browne, S. J. Chen, Donghang Yan, V. Werner, T. Isobe, R.-B. Gerst, P. Doornenbal, T. Koiwai, F. Château, A. Corsi, A. Gillibert, Takaharu Otsuka, Hiroyoshi Sakurai, A. Delbart, F. Raimondi, H. Yamada, Shuopei Wang, Y. L. Sun, Victor Vaquero, T. Motobayashi, L. X. Chung, H. Törnqvist, J. M. Gheller, Yasuhiro Togano, W. Rodriguez, Y. Chazono, A. Giganon, Carlo Barbieri, Kazuyuki Ogata, C. Lehr, Masahiro Yasuda, C. Hilaire, N. L. Achouri, Yosuke Kondo, Julien Gibelin, X. X. Xu, B. D. Linh, J. Kahlbow, Igor Gašparić, H. N. Liu, A. Obertelli, L. Zanetti, Yutaka Utsuno, Jenny Lee, Yuya Kubota, V. Lapoux, K. Yoshida, Dong-Wook Kim, O. Aktas, Zaihong Yang, I. Murray, K. I. Hahn, and L. Stuhl

Subjects
Physics, Hydrogen, Nuclear Theory, General Physics and Astronomy, chemistry.chemical_element, Impulse (physics), 01 natural sciences, Vertex (geometry), Isotopes of calcium, Transverse plane, chemistry, Excited state, 0103 physical sciences, Neutron, Atomic physics, Nuclear Experiment, 010306 general physics, Excitation
Abstract

Exclusive cross sections and momentum distributions have been measured for quasifree one-neutron knockout reactions from a ^{54}Ca beam striking on a liquid hydrogen target at ∼200 MeV/u. A significantly larger cross section to the p_{3/2} state compared to the f_{5/2} state observed in the excitation of ^{53}Ca provides direct evidence for the nature of the N=34 shell closure. This finding corroborates the arising of a new shell closure in neutron-rich calcium isotopes. The distorted-wave impulse approximation reaction formalism with shell model calculations using the effective GXPF1Bs interaction and ab initio calculations concur our experimental findings. Obtained transverse and parallel momentum distributions demonstrate the sensitivity of quasifree one-neutron knockout in inverse kinematics on a thick liquid hydrogen target with the reaction vertex reconstructed to final state spin-parity assignments.

Published
2019
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16. The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer

Author

Lisa D. Yee, Stephan Lehr, Jackelyn A. Alva-Ornelas, Ruth O'Regan, Peter Wend, C Hilaire, Tiffany N. Seagroves, Lily Yang, Robert D. Cardiff, Julio Silva, Ikbale El Ayachi, Raisa I. Krutilina, Gustavo A. Miranda-Carboni, Wendy Silva, Iram Fatima, Andrew C. White, William E. Lowry, Joseph Kerby Gray, Stephanie Runke, Victoria L. Seewaldt, William L. Kuenzinger, and Susan A. Krum

Subjects
0301 basic medicine, Cancer Research, Drug Resistance, Triple Negative Breast Neoplasms, Transgenic, Metastasis, Mice, 0302 clinical medicine, Transcription Factor 4, Antineoplastic Combined Chemotherapy Protocols, Neoplasm Metastasis, Triple-negative breast cancer, beta Catenin, Cancer, Tumor, biology, EZH2, Heterocyclic, Wnt signaling pathway, Acetylation, Drug Synergism, Middle Aged, Survival Rate, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Female, Development of treatments and therapeutic interventions, medicine.drug, Lymphoid Enhancer-Binding Factor 1, Oncology and Carcinogenesis, Mice, Transgenic, macromolecular substances, Pyrimidinones, Article, Cell Line, 03 medical and health sciences, Bridged Bicyclo Compounds, Breast cancer, HMGA2, Cell Line, Tumor, Proto-Oncogene Proteins, Breast Cancer, Biomarkers, Tumor, medicine, AXIN2, Animals, Humans, Doxorubicin, Enhancer of Zeste Homolog 2 Protein, Oncology & Carcinogenesis, Alleles, business.industry, HMGA2 Protein, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Wnt Proteins, 030104 developmental biology, Drug Resistance, Neoplasm, biology.protein, Cancer research, Neoplasm, business, Biomarkers
Abstract

Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in MMTV-Wnt10bLacZ transgenic mice during metastasis, and Hmga2 haploinsufficiency decreased EZH2 protein expression, repressing lung metastasis. A novel autoregulatory loop interdependent on HMGA2 and EZH2 expression is essential for β-CATENIN/TCF-4/LEF-1 transcription. Mechanistically, both HMGA2 and EZH2 displaced Groucho/TLE1 from TCF-4 and served as gatekeepers for K49 acetylation on β-CATENIN, which is essential for transcription. In addition, we discovered that HMGA2-EZH2 interacts with the PRC2 complex. Absence of HMGA2 or EZH2 expression or chemical inhibition of Wnt signaling in a chemoresistant patient-derived xenograft (PDX) model of TNBC abolished visceral metastasis, repressing AXIN2, MYC, EZH2, and HMGA2 expression in vivo. Combinatorial therapy of a WNT inhibitor with doxorubicin synergistically activated apoptosis in vitro, resensitized PDX-derived cells to doxorubicin, and repressed lung metastasis in vivo. We propose that targeting the WNT10B biomarker network will provide improved outcomes for TNBC. Significance: These findings reveal targeting the WNT signaling pathway as a potential therapeutic strategy in triple-negative breast cancer.

Published
2019

17. How Robust is the N=34 Subshell Closure? First Spectroscopy of Ar52

Author

Nobuyuki Chiga, T. Lokotko, Si Chen, T. Koiwai, Takashi Nakamura, D. Calvet, K. Moschner, E. Sahin, Yosuke Kondo, A. Corsi, N.L. Achouri, Kathrin Wimmer, T. Kobayashi, F. Browne, X. X. Xu, David Steppenbeck, B. D. Linh, A. Delbart, J. M. Gheller, V. Wagner, H. Törnqvist, P. Doornenbal, M. MacCormick, R.-B. Gerst, Igor Gašparić, C. Lehr, Hiroyoshi Sakurai, Masahiro Yasuda, C. Hilaire, H.N. Liu, A. Giganon, F. Flavigny, M. L. Cortés, T. Motobayashi, S. Franchoo, Thomas Aumann, C.A. Bertulani, A. Gillibert, V. Panin, Hideaki Otsu, L. X. Chung, P. A. Söderström, Gustav R. Jansen, Hirofumi Yamada, Masaki Sasano, R. Stroberg, D. Sohler, Julien Gibelin, L. Zanetti, Victor Vaquero, V. Lapoux, T. Isobe, N. Paul, S. Wang, Yasuhiro Togano, Jenny Lee, Achim Schwenk, Yuya Kubota, Satoshi Takeuchi, V. Werner, A. Obertelli, F. Château, P. Koseoglou, Gaute Hagen, Dong-Wook Kim, O. Aktas, Zaihong Yang, I. Murray, K. I. Hahn, L. Stuhl, Jason D. Holt, Tomohiro Uesaka, K. Yoneda, S. Y. Park, Duo Yan, D. M. Rossi, H. Baba, Y. L. Sun, T. D. Morris, and W. Rodriguez

Subjects
Physics, Isotope, Closure (topology), General Physics and Astronomy, 01 natural sciences, 3. Good health, Neutron number, 0103 physical sciences, Atomic number, Atomic physics, Nuclear Experiment, 010306 general physics, Spectroscopy, Nuclear theory, Excitation, Energy (signal processing)
Abstract

The first γ-ray spectroscopy of ^{52}Ar, with the neutron number N=34, was measured using the ^{53}K(p,2p) one-proton removal reaction at ∼210 MeV/u at the RIBF facility. The 2_{1}^{+} excitation energy is found at 1656(18) keV, the highest among the Ar isotopes with N>20. This result is the first experimental signature of the persistence of the N=34 subshell closure beyond ^{54}Ca, i.e., below the magic proton number Z=20. Shell-model calculations with phenomenological and chiral-effective-field-theory interactions both reproduce the measured 2_{1}^{+} systematics of neutron-rich Ar isotopes, and support a N=34 subshell closure in ^{52}Ar.

Published
2019
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18. Spectroscopy of neutron-rich scandium isotopes

Author

A. Delbart, T. Motobayashi, L. Zanetti, Julien Gibelin, Tomohiro Uesaka, T. Kobayashi, X. X. Xu, H. Toernqvist, Si-Ge Chen, P. A. Söderström, S. Wang, F. Flavigny, A. Obertelli, V. Wagner, M. Lettmann, D. Calvet, J. M. Gheller, T. Isobe, A. Giganon, F. Château, Thomas Aumann, Makoto Yasuda, Victor Vaquero, A. Gillibert, V. Panin, L. X. Chung, E. Sahin, S. Y. Park, T. Lokotko, Duo Yan, P. Doornenbal, K. Moschner, M. MacCormick, C. Hilaire, Kathrin Wimmer, Alessandra Corsi, Satoshi Takeuchi, Takashi Nakamura, R.-B. Gerst, B. D. Linh, M. L. Cortés, S. Franchoo, Igor Gašparić, H. N. Liu, K. Yoneda, C. Lehr, Jenny Lee, F. Browne, Yuya Kubota, Masaki Sasano, N. Paul, D. M. Rossi, V. Werner, Yasuhiro Togano, Yosuke Kondo, H. Baba, N. L. Achouri, Hideaki Otsu, Hirofumi Yamada, Y. L. Sun, Dong-Wook Kim, O. Aktas, V. Lapoux, Zaihong Yang, I. Murray, K. I. Hahn, David Steppenbeck, L. Stuhl, W. Rodriguez, Nobuyuki Chiga, T. Koiwai, Norbert Pietralla, D. Sohler, P. Koseoglou, Hiroyoshi Sakurai, RIKEN Nishina Center for Accelerator-Based Science, Technische Universität Darmstadt, Helmholtz Centre for Heavy Ion Research, Federal Ministry of Education and Research (Germany), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, History, Isotope, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, chemistry.chemical_element, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Computer Science Applications, Education, International school, Neutron physics, Nuclear physics, chemistry, 0103 physical sciences, Physics::Accelerator Physics, ddc:530, Neutron, Scandium, Nuclear Experiment, 010306 general physics, Spectroscopy
Abstract

7 pags., 7 figs. -- XXIII International School on Nuclear Physics, Neutron Physics and Applications 22-28 September 2019, Varna, Bulgaria, Within the SEASTAR III campaign at the Radioactive Isotope Beam Factory, at the RIKEN Nishina Center, neutron-rich isotopes in the vicinity of 53K were produced from the fragmentation of the primary 70Zn beam on a 9Be target. After nucleon knockout reactions on the secondary liquid hydrogen MINOS target the known γ rays of the neutron-rich 55Sc isotope were observed (shown in this proceedings) and γ rays from 57,59Sc isotopes have been identified for the first time. The evolution of the occupied nucleon orbitals of these nuclei in the ground and excited state is investigated under the prism of the tensor force., We are grateful to the RIKEN Nishina Center accelerator staff for their work in the primary beam delivery and the BigRIPS team for preparing the secondary beams. This work was supported by the cooperation between TU Darmstadt and the GSI Helmholtz Center for Heavy Ion Research, by the Helmholtz Graduate School for Hadron and Ion Research for FAIR and its abroad program and the BMBF under grant No. 05P19RDFN1. D.S. was supported by projects No. GINOP2.3.3-15-2016-00034 and No. K128947.

Published
2020
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19. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Author

Ruth Graham, Charlotte Eglinton, Swapna Kunhunny, J Banns, Alison K Wright, Sunil Munshi, C Khuoge, Beverley McClelland, A Benford, Jean Buxton, Maia Beridze, K Deighton, Neha Chopra, Nichola Motherwell, Emily C. O'Brien, Sonia S. Anand, Anand Dixit, Una Poultney, N Beridze, Jessica Beavan, K Dizayee, Thompson G. Robinson, Deborah Howcroft, Alison Sarah rachel Mcloughlin, A Kenton, Derek Esson, A Tittle, L Matter, Kerstin Knops, C Hubbuck, Kath Chapman, R Rangasamay, Ranjan Sanyal, Sarah Lewis, Alpha Anthony, Sarah Board, Janice Irvine, Anna Verrion, Katherine Whittamore, N Khizanishvili, L O'Shea, Lisa Shaw, K Ayes, Tracey Dobson, N Akiashvili, Gill Rogers, Jenny Peters, Alda Remegoso, S S Hansen, James A. White, T Attygalle, Rosalind Brown, Irene Martin, Manesh R. Patel, D O'Kane, Stuart J. Pocock, Khalid Rashed, G Spurling, Sharon Tysoe, Frances Harrington, Margo Henry, Rowilson Jarapa, Julia Hindle, K A Kay, Carinna Vickers, S Duty, Angela Bowring, David Eveson, Saul Sundayi, Mary Kambafwile, Rashmi Kumar, Jack Roffe, Marilyn James, Natalie Temple, R Oliver, Christine Kelly, M Niemierko, J Chembala, S Jones, M Dent, K Chatterjee, S Atkinson, J Tomlinson, S Norman, E Cattermole, P Daboo, Nicola Gilzeane, Anne Hardwick, Pietro Cariga, C Rankin, David A. Wood, Lelia Duley, John Bamford, L Holford, J Good, C Ambulo, S Gomm, Girish Muddegowda, Fiona Wright, M Alao, L Sztriha, Maite D. Rodriguez, Christine Dickson, S Merotra, Helen Bearne, Ann Needle, Emma Mckenzie, Olga Balazikova, Emily Osborne, A Lankester, Rod S Taylor, Pauline Fitzell, Bernard Esisi, E Young, Richard Donnelly, Anu Joyson, Debbie Morgan, Fran Watson, Caroline Mcinnes, C Padilla-Harris, Stephanie McCann, T Ajao, Suzanne Lucas, Inez Wynter, Barbara Longland, Don Sims, Gavin Bateman, Anthony Hemsley, Vera Cvoro, Fiona Kennedy, Peter Langhorne, Adrian Butler, P Jacob, Barry Moynihan, Amit K. Mistri, W Sunman, Hannah Beadle, Polly Scutt, M Garside, Glyn Fletcher, Deborah Walstow, L Ryan, Michelle Fawcett, D Wilkinson, E Gibson, O Orugun, Malcolm R. Macleod, Philip M.W. Bath, Elio Giallombardo, T Kherkheulidze, Lourda Kerin, Clare Doyle, Brigid Hairsine, N Kakabadze, B Wadams, Enas Lawrence, Dinesh Chadha, I Memon, Cheryl L. Perkins, Victoria Sutton, C.B. Patel, A Ravindrane, K Javaid, Mahmud Sajid, T Tsanava, Y Duodu, Timothy J. England, Geoffrey A. Rose, Sheila Nyabadza, Louisa M. Christensen, M Bajoriene, F Faola, J Kok, C Vernon, Aravindakshan Manoj, E Horsley, T Gordon, Linda Cowie, S Hurdowar, D Sandler, Temi Adedoyin, Mandy Couser, C Jenkins, C Pringle, Paula Lopez, Vicky Taylor, James Cunningham, Gillian Courtauld, S Maheswaran, H Rehman, Christine Roffe, M Sein, Carla Richardson, John B. Davis, Nenette Abano, Racquel Carpio, Sheila Mashate, P Christian, Lynn Dixon, Dulka Manawadu, Jeanette Grocott, Peter Owusu-Agyei, P Farren, F K Chan, Komal Ali, Annemarei Ranta, Judith Clarke, Dean Waugh, Stan Heptinstall, M Reader, Nikola Sprigg, John F. Corrigan, Caroline Roughan, F Brodie, Paula Harman, P Webster, Kenneth Smith, Julie Reddan, Angela Willberry, Peter Howard, Kay Finney, S Buddha, C Hewitt, M Zaidi, Tracy Marsden, Heather Gow, Robert A. Dineen, Kimberley Netherton, Kashif Musarrat, Emma Barbon, V Riddell, G Storey, Ahamad Hassan, O Adegbaju, S Wong, Bethan Charles, Bindu Gregary, Rhys Williams, M G Metiu, Nilofer Dayal, C Lawlor, Kirsten E Anderson, R Icart Palau, N Khanom, C Stevenson, Prabel Datta, Betty Mokoena, Kelly Chan, Amanda Hedstrom, Sonia Raj, Y Gruenbeck, D Dellafera, Georgina Butt, A Peacocke, James Okwera, L Mokoena, Holly Maguire, Mohana Maddula, C Bailey, Ian Shread, LáShauntá M. Glover, Elizabeth Keeling, Mari Smith, Jane Powell, A Tevdoradze, Christopher Price, Hannah Rudenko, K Gill, Laura Howaniec, P Lingwood, Katherine Marks, Ivan Iniesta, F Barrett, Barbara Madigan, Emery N. Brown, Katie Flaherty, Gail Hann, Mark Barber, Kelley Storey, Aparna Pusalkar, Jason P. Appleton, Joanne Hiden, R Jolly, Hedley C. A. Emsley, J Chambers, Christina Kruuse, Mairead Osborn, P Lai, Tracy Fuller, David G. Bruce, Robert Namushi, Martin Cooper, Peter Murphy, Naomi Jeyaraj, Hayley Kingwell, A Nair, Robert S.M. Davies, Katrina McCormick, Rachel L. Lakey, Sharon Dealing, F Leslie, Peter Wilkinson, Amitava Banerjee, Penelope Cox, Janice E. O’Connell, N Sikondari, Sandra Leason, Lisa J Woodhouse, Judith Bell, Puneet Dangri, Donna Butler, Judith Dube, Rachel Gascoyne, Amberly Brigden, Debs Kelly, Renuka Erande, Kirsty Harkness, Sarah Trippier, Kirsten Harvey, Georgina Ayres, R Rowland-Axe, E Campbell, Sue Lyjko, Sylvia Szabo, David Mangion, Suzanne Ragab, C Hilaire, Alan A Montgomery, Dawn Tomlin, John Paterson, K Muhidden, Grace Auld, C Keaveney, Hannah Crowther, Lisa Hyatt, Louise E. Jackson, K Castro, Khaled Elfandi, H Russell, S Tennant, Ozlem Redjep, Tim Cassidy, Linda Y Johnson, Amulya Misra, E Khoromana, Catherine Ovington, Stuart Maguire, S Khan, Zoe Mellor, Michael Funnell, Hugh S. Markus, Emma Richards, I Toidze, Colin Smith, R Sivakumar, Janet Wilson, Amina Ahmed, A Mohd Nor, A Barkat, Line Bentsen, K Whysall, Carol L Clarke, N Sengupta, Meena Srinivasan, Balakrishna Kumar, Mgg Soliman, A Thomson, Adrian Barry, Abul Azim, Ed Gamble, H Eccleson, Kelly Marie Shaw, Christine Schofield, Linetty Makawa, Carole Hays, David Hargroves, Jordi Margalef, S Butler, H Webb, Carol Denniss, Samantha Stafford, Faye Shelton, D Forrest, Amanda Buck, Tarn Nozedar, Indira Natarajan, Jane Perez, Susanna R. Stevens, Denise Button, Mary Johnes, Samantha Keenan, Olivia C. Geraghty, Eva Beranova, Emma Jinks, S Hassan, Caroline McGhee, Nicola Persad, Gunaratnam Gunathilagan, Clare Buckley, Jennifer Mitchell, Mike Clarke, Mathew Burn, B Bhaskaran, D Hayward, Lucy Belle Guthrie, S Meenakshisundaram, Anushka Warusevitane, O Speirs, J O'Callaghan, Sudipto Ghosh, Peter Wilding, Helen Cochrane, Susan Clayton, Mandy Doherty, Fiona Price, L Montague, Valerie Hogg, S Arif, Beth Hazel, Margaret Ball, S Johnson-Holland, S Booth, N Rands, Dionne Hove, Teresa Thompson, C Krarup Hansen, Lisa Manning, Andrew Smith, Jo Howe, Jill Greig, Kailash Krishnan, Caroline Watchurst, L Finlay, Sandra Nelson, Toby Black, S Tilby, Zin Naing, D Morse, David Broughton, K Preece, M Platton, M Siddiqui, Angela Dodd, Catrin Blank, Maria Bokhari, Jacqueline Furnace, F Hammonds, Helen Guy, A Lehman, J Hunt, S Windebank, Becky Jupp, K Fotherby, Ruth Bellfield, P Wanklyn, D Hilton, Amy Steele, S Mahmood, N Lobjanidze, Sarah Finlay, L Hunt, M Krasinska-Chavez, Gemma Grimwood, H H Jensen, J. Duignan, Jane Gaylard, Asaipillai Asokanathan, Joanna O'Reilly, J Kessell, Diane Havard, T Fluskey, L Lee-Carbon, Graham Venables, Margi Godfrey, L Boxall, C Douglass, Emelda Veraque, Elaine Amis, M Chowdhury, Rekha Keshvara, Adrian Blight, G Thomas, Marc Randall, S Stoddart, Paul Guyler, Rita Ghatala, Janet T Scott, Kathy J. Jenkins, Sarah Ross, John Aeron-Thomas, C Allcock, J Goodsell, Ifan Jones, D Kakabadze, T T Thomsen, V Petrovic, I. Watson, C Athulathmudali, Hanne Christensen, Susan Crawford, Christine Kamara, James McIlmoyle, Stephen Woodward, Christine McAlpine, Emma Temlett, Gwendoline Wilkes, Benjamin Hyams, L Mills, S Brixey, Raj Shekhar, P Findlay, Markus, Hugh [0000-0002-9794-5996], and Apollo - University of Cambridge Repository

Subjects
Male, medicine.medical_specialty, Georgia, Ticlopidine, Denmark, Hemorrhage, 030204 cardiovascular system & hematology, Risk Assessment, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Ischemia, Recurrence, Modified Rankin Scale, Internal medicine, medicine, Humans, Thrombolytic Therapy, Prospective Studies, cardiovascular diseases, Stroke, Aged, Aspirin, business.industry, Dipyridamole, General Medicine, Guideline, Middle Aged, Clopidogrel, medicine.disease, United Kingdom, Treatment Outcome, Ischemic Attack, Transient, Research Design, Acute Disease, Platelet aggregation inhibitor, Drug Therapy, Combination, Female, business, Platelet Aggregation Inhibitors, 030217 neurology & neurosurgery, New Zealand, medicine.drug
Abstract

Summary Background Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with that of guideline-based antiplatelet therapy. Methods We did an international, prospective, randomised, open-label, blinded-endpoint trial in adult participants with ischaemic stroke or transient ischaemic attack (TIA) within 48 h of onset. Participants were assigned in a 1:1 ratio using computer randomisation to receive loading doses and then 30 days of intensive antiplatelet therapy (combined aspirin 75 mg, clopidogrel 75 mg, and dipyridamole 200 mg twice daily) or guideline-based therapy (comprising either clopidogrel alone or combined aspirin and dipyridamole). Randomisation was stratified by country and index event, and minimised with prognostic baseline factors, medication use, time to randomisation, stroke-related factors, and thrombolysis. The ordinal primary outcome was the combined incidence and severity of any recurrent stroke (ischaemic or haemorrhagic; assessed using the modified Rankin Scale) or TIA within 90 days, as assessed by central telephone follow-up with masking to treatment assignment, and analysed by intention to treat. This trial is registered with the ISRCTN registry, number ISRCTN47823388. Findings 3096 participants (1556 in the intensive antiplatelet therapy group, 1540 in the guideline antiplatelet therapy group) were recruited from 106 hospitals in four countries between April 7, 2009, and March 18, 2016. The trial was stopped early on the recommendation of the data monitoring committee. The incidence and severity of recurrent stroke or TIA did not differ between intensive and guideline therapy (93 [6%] participants vs 105 [7%]; adjusted common odds ratio [cOR] 0·90, 95% CI 0·67–1·20, p=0·47). By contrast, intensive antiplatelet therapy was associated with more, and more severe, bleeding (adjusted cOR 2·54, 95% CI 2·05–3·16, p Interpretation Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice. Funding National Institutes of Health Research Health Technology Assessment Programme, British Heart Foundation.

Published
2017

20. Les inventions hydrauliques dans l'Antiquité romaine : entre fictions littéraires et réalités archéologiques

Author

Hélène Dessales, Archéologies d'Orient et d'Occident et Sciences des textes (AOROC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Corcy M.-S., Douyère-Demeulenaere C., Hilaire-Pérez L., Dessales, Hélène, and Corcy M.-S., Douyère-Demeulenaere C., Hilaire-Pérez L.

Subjects
History, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, archive, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, archéologie, histoire, invention, Antiquité romaine, industrialisation, ComputingMilieux_MISCELLANEOUS, sources littéraires, Techniques hydrauliques
Abstract

Le choix de privilégier le cas des inventions hydrauliques dans l’Antiquité romaine découle de plusieurs constats, à des degrés de lecture différents. D’une part, ces inventions apparaissent, dans les sources écrites du moins, mais aussi à travers les vestiges archéologiques, comme un héritage technique de la Grèce et de l’Orient : c’est donc s’interroger sur leur statut d’inventio, en tant que création résolument nouvelle, et plus généralement, sur la nature des progrès techniques de la Rome...

Published
2003

21. Prevalence of HIV, Hepatitis C and Hepatitis B Infection Among Detainees in a French Administrative Detention Centre.

Author

Mancy S, Fabbro-Peray P, Alonso S, Berkaoui H, Lambremon L, Vidal H, Hilaire C, Herrmann D, Dapoigny J, and Kinné M

Subjects
Humans, Male, Female, Adult, Prevalence, France epidemiology, Cross-Sectional Studies, Prospective Studies, Pilot Projects, Prisoners statistics & numerical data, Middle Aged, Coinfection epidemiology, Young Adult, Hepatitis B epidemiology, Hepatitis B diagnosis, Hepatitis C epidemiology, Hepatitis C diagnosis, HIV Infections epidemiology, HIV Infections diagnosis
Abstract

Background: In France, migrants constitute a significant proportion of people diagnosed with HIV, hepatitis C (HCV) and B (HBV). This study estimated the prevalence of these three viruses among detainees at a French administrative detention centre (CRA), through systematic Rapid Diagnostic Test (RDT) screening., Methods: This prospective, single-centre, cross-sectional, pilot study included detainees at the Nîmes CRA from February to December 2022. The primary endpoint was HIV, HCV and HBV prevalence determined by RDT. Secondary outcomes were: co-infections; study acceptability, reasons for non-inclusion, causes of non-contributory samples; and concordance between serological tests and RDT., Results: Among the 350 people agreeing to participate of 726 eligible, five refused the RDT, leaving 345 analysable participants for a participation rate of 47.5% (345/726). Participants were predominantly male (90%) with an average age of 31 years. The most common country of origin was Algeria (34%). Twenty (6%) had taken drugs intravenously and 240 (70%) had had unprotected sex within a median of 4.92 [1.08; 15] months. Virus prevalence was: 0% HIV; 4.64 [2.42; 6.86] % HCV; and 2.32 [1.01; 4.52] % HBV. Eleven (73%) of the RDT HCV positive cases were confirmed serologically. RDT detected one false-positive HCV case, as an anti-HCV Ac serological test was negative. Of the eight patients with positive HBV RDT, one declined the serology testing, thus 100% (7/7) of the tested RDT positive cases were confirmed by serology., Conclusion: The study highlighted the need to screen detainees for HIV, HCV and HBV infection and suitability of RDTs., (© 2024. The Author(s).)

Published
2024
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22. The Secretome of Human Dental Pulp Stem Cells and Its Components GDF15 and HB-EGF Protect Amyotrophic Lateral Sclerosis Motoneurons against Death.

Author

Younes R, Issa Y, Jdaa N, Chouaib B, Brugioti V, Challuau D, Raoul C, Scamps F, Cuisinier F, and Hilaire C

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable paralytic disorder caused by the progressive death of upper and lower motoneurons. Although numerous strategies have been developed to slow disease progression and improve life quality, to date only a few therapeutic treatments are available with still unsatisfactory therapeutic benefits. The secretome of dental pulp stem cells (DPSCs) contains numerous neurotrophic factors that could promote motoneuron survival. Accordingly, DPSCs confer neuroprotective benefits to the SOD1 G93A mouse model of ALS. However, the mode of action of DPSC secretome on motoneurons remains largely unknown. Here, we used conditioned medium of human DPSCs (DPSCs-CM) and assessed its effect on survival, axonal length, and electrical activity of cultured wildtype and SOD1 G93A motoneurons. To further understand the role of individual factors secreted by DPSCs and to circumvent the secretome variability bias, we focused on GDF15 and HB-EGF whose neuroprotective properties remain elusive in the ALS pathogenic context. DPSCs-CM rescues motoneurons from trophic factor deprivation-induced death, promotes axon outgrowth of wildtype but not SOD1 G93A mutant motoneurons, and has no impact on the spontaneous electrical activity of wildtype or mutant motoneurons. Both GDF15 and HB-EGF protect SOD1 G93A motoneurons against nitric oxide-induced death, but not against death induced by trophic factor deprivation. GDF15 and HB-EGF receptors were found to be expressed in the spinal cord, with a two-fold increase in expression for the GDF15 low-affinity receptor in SOD1 G93A mice. Therefore, the secretome of DPSCs appears as a new potential therapeutic candidate for ALS., Competing Interests: The authors declare no conflict of interest.

Published
2023
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23. Synaptic Transmission and Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis

Author

Scamps F, Aimond F, Hilaire C, Raoul C, and Araki T

Abstract

Amyotrophic lateral sclerosis is a fatal adult-onset neurodegenerative disease characterized by progressive muscular weakness and atrophy. The primary feature of amyotrophic lateral sclerosis is the selective loss of motoneurons in the brain and spinal cord. However, changes in synaptic transmission and motoneuron excitability are among the first events that take place during development and accompany the relentless deterioration of motor circuitry. This chapter aims to summarize the current understanding of defects in intrinsic electrophysiological properties of motoneurons, local GABAergic and glycinergic inhibitory as well as cholinergic modulatory interneuron networks, and long-range glutamatergic excitatory input neurons that can precede disease onset or occur during the progression of the disease. We summarize evidence that therapeutic options that target synaptic transmission and intrinsic features of motoneurons might represent novel effective strategies for patients with amyotrophic lateral sclerosis., (Copyright: The Authors.)

Published
2021
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24. Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis.

Author

Soulard C, Salsac C, Mouzat K, Hilaire C, Roussel J, Mezghrani A, Lumbroso S, Raoul C, and Scamps F

Subjects
Animals, Biomarkers metabolism, Chloride Channels metabolism, Choline metabolism, Disease Progression, Exons genetics, HEK293 Cells, Humans, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Receptors, Muscarinic metabolism, Sequence Deletion genetics, Amyotrophic Lateral Sclerosis pathology, Amyotrophic Lateral Sclerosis physiopathology, Anoctamins metabolism, Motor Activity, Motor Neurons metabolism, Motor Neurons pathology, Phospholipid Transfer Proteins metabolism, Presynaptic Terminals pathology, Spinal Cord pathology
Abstract

Neuronal Ca 2+ entry elicited by electrical activity contributes to information coding via activation of K + and Cl - channels. While Ca 2+ -dependent K + channels have been extensively studied, the molecular identity and role of Ca 2+ -activated Cl - channels (CaCCs) remain unclear. Here, we demonstrate that TMEM16F governs a Ca 2+ -activated Cl - conductance in spinal motoneurons. We show that TMEM16F is expressed in synaptic clusters facing pre-synaptic cholinergic C-boutons in α-motoneurons of the spinal cord. Mice with targeted exon deletion in Tmem16f display decreased motor performance under high-demanding tasks attributable to an increase in the recruitment threshold of fast α-motoneurons. Remarkably, loss of TMEM16F function in a mouse model of amyotrophic lateral sclerosis (ALS) significantly reduces expression of an activity-dependent early stress marker and muscle denervation, delays disease onset, and preserves muscular strength only in male ALS mice. Thus, TMEM16F controls motoneuron excitability and impacts motor resistance as well as motor deterioration in ALS., Competing Interests: Declaration of Interests Authors declare no competing interests., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2020
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25. Myotube elasticity of an amyotrophic lateral sclerosis mouse model.

Author

Varga B, Martin-Fernandez M, Hilaire C, Sanchez-Vicente A, Areias J, Salsac C, Cuisinier FJG, Raoul C, Scamps F, and Gergely C

Subjects
Actins genetics, Amyotrophic Lateral Sclerosis physiopathology, Animals, Cell Differentiation genetics, Disease Models, Animal, Elasticity physiology, Gene Expression Regulation drug effects, Humans, Mechanical Phenomena, Mice, Microscopy, Atomic Force, Muscle Fibers, Skeletal pathology, Muscle Fibers, Skeletal ultrastructure, Muscle Weakness genetics, Mutation, Myosins genetics, Superoxide Dismutase-1 chemistry, Amyotrophic Lateral Sclerosis genetics, Muscle Development genetics, Muscle Fibers, Skeletal chemistry, Superoxide Dismutase-1 genetics
Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor system leading to generalized paralysis and death of patients. The understanding of early pathogenic mechanisms will help to define early diagnostics criteria that will eventually provide basis for efficient therapeutics. Early symptoms of ALS usually include muscle weakness or stiffness. Therefore, mechanical response of differentiated myotubes from primary cultures of mice, expressing the ALS-causing SOD1 G93A mutation, was examined by atomic force microscopy. Simultaneous acquisition of topography and cell elasticity of ALS myotubes was performed by force mapping method, compared with healthy myotubes and supplemented with immunofluorescence and qRT-PCR studies. Wild type myotubes reveal a significant difference in elasticity between a narrow and a wide population, consistent with maturation occurring with higher actin expression relative to myosin together with larger myotube width. However, this is not true for SOD1 G93A expressing myotubes, where a significant shift of thin population towards higher elastic modulus values was observed. We provide evidence that SOD1 mutant induces structural changes that occurs very early in muscle development and well before symptomatic stage of the disease. These findings could significantly contribute to the understanding of the role of skeletal muscle in ALS pathogenesis.

Published
2018
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26. Development of a sublingual allergy vaccine for grass pollinosis.

Author

Frati F, Scurati S, Puccinelli P, David M, Hilaire C, Capecce M, Marcucci F, and Incorvaia C

Subjects
Administration, Sublingual, Allergens immunology, Dendritic Cells immunology, Humans, Immunotherapy adverse effects, Mouth Mucosa immunology, Poaceae immunology, Pollen immunology, Rhinitis, Allergic, Seasonal immunology, Desensitization, Immunologic methods, Immunotherapy methods, Rhinitis, Allergic, Seasonal therapy
Abstract

Grass pollen is a very common cause of allergic rhinitis and asthma. The only treatment targeting the underlying causes of allergy is immunotherapy (IT). Sublingual immunotherapy (SLIT) has been introduced to solve the problem of systemic reactions to subcutaneous IT (SCIT). This article evaluates the characteristics of the allergen extract, Staloral, in terms of practical administration, effectiveness, safety, and mechanism of action. Efficacy data were obtained from double-blind, placebo-controlled studies using Staloral in patients sensitized to grass pollen, while practical administration, cost-effectiveness, and mechanism of action data were provided by well designed studies. The efficacy and safety of Staloral, as demonstrated by review of published studies which used doses up to 1125 times those administered with SCIT, shows that this allergen extract has optimal characteristics for treating patients with seasonal allergies due to grass pollens. The main mechanism of action is the interaction between dendritic cells of the oral mucosa and the subsequent tolerance induced in T-cells.

Published
2010
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27. Adherence issues related to sublingual immunotherapy as perceived by allergists.

Author

Scurati S, Frati F, Passalacqua G, Puccinelli P, Hilaire C, and Incorvaia C

Abstract

Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence., Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10., Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists., Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.

Published
2010
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28. Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.

Author

Boudes M, Sar C, Menigoz A, Hilaire C, Péquignot MO, Kozlenkov A, Marmorstein A, Carroll P, Valmier J, and Scamps F

Subjects
Animals, Bestrophins, Cell Membrane metabolism, Eye Proteins genetics, Gene Knockdown Techniques, Green Fluorescent Proteins genetics, Ion Channels, Membrane Potentials physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Patch-Clamp Techniques, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Transfection, Calcium metabolism, Chlorides metabolism, Eye Proteins metabolism, Ganglia, Spinal physiology, Sciatic Nerve injuries, Sensory Receptor Cells physiology
Abstract

We investigated the molecular determinants of Ca(2+)-activated chloride current (CaCC) expressed in adult sensory neurons after a nerve injury. Dorsal root ganglia express the transcripts of three gene families known to induce CaCCs in heterologous systems: bestrophin, tweety, and TMEM16. We found with quantitative transcriptional analysis and in situ hybridization that nerve injury induced upregulation of solely bestrophin-1 transcripts in sensory neurons. Gene screening with RNA interference in single neurons demonstrated that mouse Best1 is required for the expression of CaCC in injured sensory neurons. Transfecting injured sensory neurons with bestrophin-1 mutants inhibited endogenous CaCC. Exogenous expression of the fusion protein green fluorescent protein-Bestrophin-1 in naive neurons demonstrated a plasma membrane localization of the protein that generates a CaCC with biophysical and pharmacological properties similar to endogenous CaCC. Our data suggest that Best1 belongs to a group of genes upregulated by nerve injury and supports functional CaCC expression in injured sensory neurons.

Published
2009
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29. NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons.

Author

Pieraut S, Laurent-Matha V, Sar C, Hubert T, Méchaly I, Hilaire C, Mersel M, Delpire E, Valmier J, and Scamps F

Subjects
Age Factors, Animals, Cells, Cultured, Humans, Intracellular Fluid metabolism, Intracellular Fluid physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurites drug effects, Neurites metabolism, Neurons, Afferent drug effects, Neurons, Afferent metabolism, Phosphorylation drug effects, Sodium-Potassium-Chloride Symporters deficiency, Sodium-Potassium-Chloride Symporters genetics, Sodium-Potassium-Chloride Symporters physiology, Solute Carrier Family 12, Member 2, Neurites physiology, Neurons, Afferent physiology, Sodium-Potassium-Chloride Symporters metabolism
Abstract

Peripheral nerve section promotes regenerative, elongated neuritic growth of adult sensory neurons. Although the role of chloride homeostasis, through the regulation of ionotropic GABA receptors, in the growth status of immature neurons in the CNS begins to emerge, nothing is known of its role in the regenerative growth of injured adult neurons. To analyze the intracellular Cl- variation after a sciatic nerve section in vivo, gramicidin perforated-patch recordings were used to study muscimol-induced currents in mice dorsal root ganglion neurons isolated from control and axotomized neurons. We show that the reversal potential of muscimol-induced current, E(GABA-A), was shifted toward depolarized potentials in axotomized neurons. This was attributable to Cl- influx because removal of extracellular Cl- prevented this shift. Application of bumetanide, an inhibitor of NKCC1 cotransporter and E(GABA-A) recordings in sensory neurons from NKCC1-/- mice, identified NKCC1 as being responsible for the increase in intracellular Cl- in axotomized neurons. In addition, we demonstrate with a phospho-NKCC1 antibody that nerve injury induces an increase in the phosphorylated form of NKCC1 in dorsal root ganglia that could account for intracellular Cl- accumulation. Time-lapse recordings of the neuritic growth of axotomized neurons show a faster growth velocity compared with control. Bumetanide, the intrathecal injection of NKCC1 small interfering RNA, and the use of NKCC1-/- mice demonstrated that NKCC1 is involved in determining the velocity of elongated growth of axotomized neurons. Our results clearly show that NKCC1-induced increase in intracellular chloride concentration is a major event accompanying peripheral nerve regeneration.

Published
2007
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30. Controlled excitations of the Belousov-Zhabotinsky reaction: Experimental procedures.

Author

Peralta C, Frank C, Zaharakis A, Cammalleri C, Testa M, Chaterpaul S, Hilaire C, Lang D, Ravinovitch D, Sobel SG, and Hastings HM

Subjects
Catalysis, Computer Simulation, Ions, Kinetics, Time, Bromides chemistry, Models, Chemical, Phenanthrolines chemistry, Silver chemistry
Abstract

The purpose of this research was to explore the unstirred, ferroin-catalyzed Belousov-Zhabotinsky (BZ) reaction as an experimental model for the response of excitable media to small perturbations (slightly larger than the threshold for excitations). Following Showalter et al. (Showalter, K.; Noyes, R. M.; Turner, H. J.Am. Chem. Soc. 1979, 101, 7463-69), we used a positively biased silver electrode to release silver ions into a BZ reaction mixture, removing bromide ions and causing an excitation if sufficient bromide was removed. We found (1) a scaling region in which the delay before activation increased linearly as the size of the perturbation decreased, qualitatively consistent with but not fully explained by the Oregonator of Field et al. (Field, R. J.; Körõs, E.; Noyes, R. M. J. Am. Chem. Soc. 1972, 94, 8649-64); (2) evidence for a 10 s oligomerization time scale; and (3) that activations were always delayed until after the end of a pulse of current, with the delay essentially constant for sufficiently long pulses, an effect not seen in simple ODE models but consistent with the anomalously large current apparently required for activation (Showalter, K.; Noyes, R. M. J. Am. Chem. Soc. 1976, 98, 3730-31) and explainable by bromide transport. Overall, the BZ system appeared to be well-suited as an experimental prototype, despite its complexity.

Published
2006
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