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This research examines the effect of the guided inquiry learning model on students' creative thinking abilities, focusing on studying chemical reaction rate material in Class XI Science at SMAN 4 Praya. This research adopts a quantitative research design with a quasi-experimental research type. The population in this study were all class XI MIPA students at SMAN 4 Praya, consisting of 237 people spread across 7 classes. The sampling technique uses non-probability sampling, seeing a similarity in students' average daily test scores with students in classes XI IPA 3 as the control class and XI IPA 6 as the experimental class. The experimental group was given a guided inquiry learning model, while the control group used conventional teaching methods. This research assesses creative thinking abilities through a description test including three indicators: originality, fluency, and flexibility. In this research, the data analysis technique uses a series of statistical tests, including the Kolmogorov-Smirnov normality and homogeneity tests. Hypothesis testing uses the independent sample t-test. The hypothesis test showed that the t-test results prove that tcount ≥ ttable , namely 4.31 ≥ 2.03, and a significant value of 0.00 ˃ 0.05, then H0 is rejected, and H1 is accepted. Thus, it can be concluded that the guided inquiry learning model positively affects students' creative thinking abilities in the reaction rate material for class XI Science at SMAN 4 Praya. This can also be seen from the results that the average value of the experimental group is higher than the control group's, with the experimental class's average value being 79.03% and the average value of the control class being 62.42%.

The role of local government in regional development planning is an essential topic in the context of sustainable local development. This study aimed to analyze the role of local governments in regional development planning and their impact on the effectiveness and sustainability of development at the local level. The research method used is a qualitative approach with data collection techniques through in-depth interviews, participatory observation, and document analysis related to regional development policies and regulations. This research was conducted in several districts/cities in certain regions, considering diverse geographical, social, and economic contexts. The results showed that the role of local governments in regional development planning is vital in coordinating various interests, resources, and related actors. Local governments act as regulators, facilitators, and implementers in determining the direction, policies, and allocation of development resources. In addition, community and private-sector involvement is also recognized as an integral part of democratic and inclusive planning processes. The impact of the role of local governments in regional development planning can be seen in increasing the effectiveness of development programs, increasing community participation, reducing regional disparities, and improving the community’s quality of life. Nevertheless, challenges such as corruption, lack of interagency coordination, and political uncertainty remain obstacles that must be overcome. This study concludes that the role of local governments in regional development planning is a critical factor in achieving sustainable regional development. Therefore, measures are needed to strengthen institutional capacity, increase transparency, and strengthen public participation to ensure sustainable and inclusive development planning at the local level.

Background: The World Health Organization (WHO) recommends exclusive breastfeeding for six months. Many intervention programs to increase the coverage of exclusive breastfeeding have been carried out, but the coverage of exclusive breastfeeding has not increased significantly. A systematic review analyzed several factors that influence exclusive breastfeeding in developing countries. Mother's occupation was found to be the most frequently mentioned obstacle. Objective: These studies show that the working status of the mother is something that greatly influences the success of exclusive breastfeeding. Methods: This research is a qualitative phenomenological study to see the support and barriers to exclusive breastfeeding for mothers who work in Sukoharjo. Results: The theme found in this study is the support and inhibition of exclusive breastfeeding for working mothers as seen from the Theory of Planned Behavior and Social Cognitive Theory. The obstacles are: 1) incorrect knowledge about exclusive breastfeeding, 2) barriers from some health workers/institutions, 3) families do not support exclusive breastfeeding, 4) there is no regulation on exclusive breastfeeding in the workplace, 5) the workplace does not yet have a special place for pumping and storing breast milk, 6) does not have a role model, 7) breast milk is reduced by working, 8) already has the intention to mix with formula milk, 9) low self-efficacy, and 10) barriers from the baby's internal factors. The supports are: 1) support from health workers/institutions, 2) the workplace provides a special room for pumping and/or storing breast milk, 3) there is an opportunity for pumping breast milk in the workplace, 4) peer support, 5) there is a high expectation of health. good, 6) intention to exclusively breastfeed, 7) good self-efficacy, 8) family support, 9) leave from work and light workload, 10) skills in breastfeeding, 11) no obstacles from the leadership, and 12) smooth mother's milk. Conclusion: This shows that SCT and TPB can be used as a theory to see the variables that influence the practice of exclusive breastfeeding. There is one finding that cannot be directly included in the SCT and/or TPB constructs, namely: skills in providing breast milk.

Background: Globally, a rising trend has been observed in the prevalence of thyroid disorders, with many demographic and geographic factors influencing its epidemiology. Nonetheless, some cases often go undetected due to the inconsistent and non-specific nature of the clinical symptoms. Therefore, we aimed to determine the trend and relationship between various pathological findings in thyroid disease patients and their demographic factors to aid clinicians in making a prompt diagnosis and treatment plan. Methods: A descriptive correlational study was conducted from January 2020 to May 2022 at Jinnah Postgraduate Medical Center, Karachi. We collected data via random sampling from 258 patients suffering from thyroid disorders. We evaluated baseline patient characteristics, along with, thyroid scan and fine needle aspiration cytology (FNAC) reports, and local thyroid gland examination findings. Results: Out of 258 participants, 192 (74.4%) were females, whereas 66 (25.6%) were males, giving a female: male ratio of 2.9: 1. On local examination, 167 (64.7%) were found to have a solitary nodule, 79 (30.6%) had multinodular goiter. Findings revealed that benign follicular lesions had the highest prevalence (35.3%). Moreover, among the cancerous growth, papillary carcinoma presented the highest cases (12.4%). Of 258 cases, 24 patients had non-surgical interventions, while most (234) had surgical interventions. Total thyroidectomy was the most common procedure opted for by 45.3% (n = 117) of the participants, followed by lobectomy 70 (27.1%), near total thyroidectomy 43 (13.2%), modified radical neck dissection 5 (1.9%). Conclusion: Our study showed that nearly all thyroid-related pathologies were more prevalent amongst females than males, with the majority having an acute to sub-acute clinical presentation. Multinodular goiter was a prominent finding indicating a greater need for screening tools and access to healthcare facilities, especially in rural areas, to allow future studies to compare provinces accurately.

Lahan pertanian, terutama di daerah tropis seperti Indonesia, umumnya telah mengalami proses degradasi secara intensif, yang dipicu oleh tingginya intensitas curah hujan dan praktek pemanfaatan lahan yang kurang mengindahkan prinsip konservasi tanah dan air. Akibatnya, telah terjadi kerusakan lingkungan dan penurunan tingkat kesuburan tanah-tanah pertanian dari tahun ketahun, dengan konsekuensi berupa makin rendahnya produktifitas lahan-lahan pertanian tersebut. Penelitian yang dilaksanakan di Kecamatan Parangloe, Kabupaten Gowa, Provinsi Sulawesi Selatan ini, bertujuan untuk mengevaluasi status kerusakan tanah pada lahan budidaya pertanian (lahan kering/cabe, lahan kering/jagung, lahan kering/rambutan dan sawah), dan dibandingkan dengan status kerusakan tanah pada areal non-budidaya (hutan sekunder, semak belukar). Metode penilaian status kerusakan tanah yang digunakan adalah sesuai PERMEN LH No. 07 Tahun 2006 tentang Tata Cara Pengukuran Kriteria Baku Kerusakan Tanah Untuk Produksi Biomassa. Hasil studi mengindikasikan bahwa, dengan menggunakan kriteria Status Kerusakan Tanah pada PERMEN LH No. 07 Tahun 2006 maka, tidak ditemukan adanya perbedaan status kerusakan tanah antara areal bididaya dan areal non-budidaya. Dengan kata lain, parameter yang digunakan untuk menilai Status Kerusakan Tanah pada PERMEN LH No. 07 Tahun 2006 ini, kurang sensitif dipakai untuk menilai perbedaan status kerusakan tanah pada areal budidaya dan areal non-budidaya.

Background - The new increasing homeless lately consist of women, children, youth, the elderly and marginalized ethnic or migrant groups. Some of them are working and earn salaries, however, the income is not sufficient to live modestly. Purpose – The purpose of this research is to establish a desired support system to eradicate urban homelessness in the country. Design/methodology/approach – This is an exploratory descriptive method study which employed quantitative techniques. The study employed a social ecological model to investigate behavior of homeless via multiple levels of influences including intrapersonal, interpersonal, organizational, community and public policy. Surveys have been conducted on sixty-five homeless individuals. Findings – It was found that support systems and structures should be derived from the whole streams from families, communities, organizations and government. Employment opportunities, long-term shelters within the community places and highly demanded skills are needed to improve their living condition. Research limitations – This study is only focused on the socio-economic structures of the homeless in a capital city. Originality/value – This is an empirical research using a social ecological model for the homeless in the Kuala Lumpur area. Research on homeless study has received little attention and has yet to be fully explored.

Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition affecting 25%–40% of the worldwide population. NAFLD is traditionally related to obesity and metabolic disorders. NAFLD can also affect non-obese individuals, termed “lean NAFLD” (LN), who exhibit a paradoxical combination of physical leanness and metabolic obesity. Factors contributing to LN remain unclear, necessitating further research. This analysis aims to understand LN’s prevalence and metabolic characteristics compared to obese NAFLD (ON) populations. Methods: This meta-analysis searched various databases until August 1, 2023. Inclusion criteria involved observational studies comparing LN with overweight/obese NAFLD. Data extraction included baseline characteristics, disease occurrence, metabolic profile, and clinical parameters—statistical analysis employed calculating risk ratios (RR) and standard mean differences. Results: Twenty-five studies were analyzed. LN is associated with lower prevalence in both NAFLD (RR 0.27, 95% confidence interval (CI) 0.14–0.52, p =

The research aims to reveal school members’ role in the organizational culture development in increasing skills in Vocational High Schools. The study method used was ethnographic with a qualitative approach. Data collection employed interviews and observations. Interviews were conducted with principals, teachers, students, and students’ parents in Vocational High Schools in Sukoharjo Regency, Central Java Province, Indonesia. Data analysis used interactive analysis, and its validity was checked by triangulation. The results showed that the principal's role in developing organizational culture was to establish organizational culture through the school's vision and mission, develop work programs, and establish school regulations. Provide guidance to school residents in two ways: structurally and non-structurally. Delegating tasks and authorities according to the expertise of each teacher and staff. Provide assessments and rewards and carry out coordination and supervision. At the same time, the role of the teacher is to continue and develop the values of life. Train to develop skills in students. In addition, the role of parents or families in children's education clearly affects the personality of children or students. The family environment was the first and main medium that directly or indirectly influenced behavior in student development.

Abstract Background Benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) are pro-inflammatory cytokine interleukin-8 (IL-8)-associated which causes epithelial hyperplasia of the prostate transitional zone. This study aimed to determine the correlation between the levels of IL-8 serum and the prostate volume with the degree of LUTS severity in patients with BPE. Methods Determination of the correlation between serum IL-8 levels and prostate volume with the LUTS severity degree was conducted using a cross-sectional approach. The International Prostate Symptom Score was used to measure the LUTS severity degree, the enzyme-linked immunosorbent assay (ELISA) technique was used to measure the serum IL-8 level, and the transabdominal ultrasonography (TAUS) was used to measure the prostate volume. The sample used in this study was 32 patients with BPE grouped by the degree of LUTS severity of the patients. The correlation between variables was then analyzed using the Pearson correlation test. Results The prostate volume was higher in severe LUTS degree (38.19 cc) than in the mild LUTS degree (13.05 cc). The levels of serum IL-8 were higher in the severe LUTS degree (21.65 pg/mL) than in the mild LUTS degree (8.44 pg/m). Both the levels of serum IL-8 and the degree of LUTS did not have a significant correlation with the volume of prostate (p > 0.05). On the other side, the prostate volume and the degree of LUTS severity had a significant positive correlation (p = 0.001, R = 0.913). Conclusion The prostate volume and the levels of serum IL-8 are higher in the severe LUTS degree. There is a trend of increasing prostate volume with the severity of LUTS symptoms and higher serum IL-8 levels. The severity of prostate enlargement can be assessed by measuring the levels of IL-8 in the serum.

Abstract Background Nivolumab (Nivo) and ipilimumab (Ipi) have revolutionized cancer treatment by targeting different pathways. Their combination shows promising results in various cancers, including melanoma, but not all studies have demonstrated significant benefits. A meta-analysis was performed to assess the effectiveness and safety of Nivo-Ipi compared to Nivo alone in advanced cancer types (excluding melanoma). Methods Following PRISMA guidelines, we conducted a meta-analysis up to September 30, 2023, searching databases for randomized controlled trials (RCTs). We focused on advanced solid malignancies (excluding melanoma) with specific Nivo and Ipi dosing. Primary outcomes were overall survival (OS), progression-free survival (PFS), grades 3–4 adverse events (AEs), and treatment-related discontinuations. Secondary outcomes included specific adverse events. Statistical analysis in Review Manager included hazard ratio (HR) and risk ratio (RR), assessing heterogeneity (Higgins I 2). Results Nine RCTs, involving 2152 patients covering various malignancies, were analyzed. The Nivo plus Ipi group exhibited a median OS of 12.3 months and a median PFS of 3.73 months, compared to monotherapy with 11.67 months and 3.98 months, respectively. OS showed no significant difference between Nivo and Ipi combination and Nivo alone (HR = 0.97, 95% CI: 0.88 to 1.08, p = 0.61). PFS had a slight improvement with combination therapy (HR = 0.91, 95% CI: 0.82 to 1.00, p = 0.04). Treatment-related cumulative grades 3–4 adverse events were higher with Nivo and Ipi (RR = 1.52, 95% CI: 1.30 to 1.78, p

Jurnal ini bertujuan untuk menambah pemahaman masyarakat tentang penggunaan lampu rotator oleh Satpol PP Kota Jambi. Diantaranya adalah bagaimana ketentuan penggunaan lampu rotator oleh Satpol PP menurut Undang-Undang Nomor 22 Tahun 2009 Tentang Lalu Lintas dan Angkutan Jalan dan tingkat efektivitas penggunaan lampu rotator oleh Satpol PP Kota Jambi. Jurnal ini menggunakan pendekatan sosiologi hukum dengan metode pengumpulan data melalui observasi, wawancara, dan dokumentasi. Berdasarkan penelitian yang dilakukan diperoleh hasil dan kesimpulan sebagai berikut: 1) penggunaan lampu rotator oleh Satpol PP di atur di Undang-Undang Nomor 23 Tahun 2014 Tentang Pemerintah, ketentuan lebih lanjut tentang Satpol PP di atur di Peraturan Pemerintah Nomor 16 Tahun 2018 Tentang Satuan Polisi Pamong Praja, Undang-Undang Nomor 22 Tahun 2009 Tentang Lalu Lintas dan Angkutan Jalan tidak mengatur secara jelas penggunaan lampu rotator oleh Satpol PP tetapi hanya mengatur secara umum tentang tata cara berlalu lintas. 2) lampu rotator yang digunakan oleh Satpol PP Kota Jambi sangat efektif digunakan dalam menjalankan tugas ketika dalam keadaan urgen karena lampu rotator ini bisa menjadi notifikasi bagi masyarakat untuk mengetahui bahwa ketika lampu rotator di hidupkan bahwa ada keadaan yang sangat genting untuk di dahulukan. Kata kunci: Efektivitas, Lampu Rotator, Satuan Polisi Pamong Praja

Abstract: Writing this article aims to find out how the extracurricular management process starts from planning, organizing, implementing, and supervising as a vehicle for educating the character of students at MI Manarul Islam and MI Khadijah Malang City. This article uses a qualitative approach with a multi-site study type of research. Data collection techniques through in-depth interviews, observation, and documentation. The informants in this study were school principals, student assistants, extracurricular coordinators, and extracurricular coaches. The results of this study indicate that the extracurricular management process in Madrasah Ibtidaiyah supports the development of the character of students, namely cooperation, religion, tolerance, mutual assistance, integrity, respect for differences, sportsmanship, maintaining cleanliness, training leadership, discipline, independence, self-confidence, responsibility, obedience , never give up, work hard, concentrate and focus, these characters will affect learning at school and outside of school. Keywords: management; extracurricular; student character Abstrak: Penulisan artikel ini bertujuan untuk mengetahui bagaimana proses manajemen ekstrakurikuler mulai dari perencanaan, pengorganisasian, pelaksanaan, dan pengawasan sebagai wahana mendidik karakter peserta didik di MI Manarul Islam dan MI khadijah Kota Malang. Artikel ini menggunakan pendekatan kualitatif dengan jenis penelitian studi multi situs. Teknik pengumpulan data melalui wawancara mendalam, observasi, dan dokumentasi. Informan dalam penelitian ini yaitu kepala sekolah, waka kesiswaan, koordinator ekstrakurikuler, dan pembina ekstrakurikuler. Hasil penelitian ini menunjukkan bahwa proses manajemen ekstrakurikuler di Madrasah Ibtidaiyah menunjang pengembangan karakter peserta didik yaitu bekerja sama, religius, bertoleransi, saling membantu, integritas, menghormati perbedaan, sportifitas, menjaga kebersihan, melatih kepemimpinan, disiplin, mandiri, percaya diri, bertanggungjawab, ketaatan, pantang menyerah, bekerja keras, berkonsentrasi dan fokus, karakter tersebut akan berpengaruh terhadap pembelajaran di sekolah maupun di luar sekolah. Kata kunci: manajemen; ekstrakurikuler; karakter peserta didik

Stridor is an important symptom which should not be missed, especially in a child. The etiology could be multifactorial and will require a comprehensive investigation into its management. In this case, we discuss the clinician’s dilemma in reaching a diagnosis due to various factors which were present in a single patient. This rare benign laryngeal squamous polyp was eventually diagnosed in an 11-week-old boy who presented with acute stridor. The diagnostic dilemma we discuss in this case was due to multiple maternal and fetal factors. He was a premature baby, intubated at birth, there was a maternal tuberculosis infection and he also had a cutaneous hemangioma which were all part of the diagnostic dilemma faced in his management which eventually led to an acquired subglottic stenosis. Our discussion will focus on how a thorough and proper evaluation is needed especially when there are many deceptive clues or signs present in a patient.

Salivary gland tumors are relatively uncommon neoplasms, presenting a diagnostic challenge for both clinicians and pathologists. When performing a biopsy, there is often an impasse between both specialists, with the clinician trying to remove as little tissue as possible and the pathologist in a perpetual quest for more. While immunohistochemistry (IHC), coupled with hematoxylin-eosin staining greatly helps in reaching a precise diagnosis and framing a management plan, there are no existing guidelines for the implementation of IHC panels in the diagnostic work-up of salivary gland tumors. The main objective of this review is to provide an up-to-date summary of the application of IHC in the diagnosis of salivary gland malignancies and the current treatment strategies. For this narrative review, we identified 50 meta-analyses and systematic reviews published between September 2013 and September 2023 using the PubMed and Google Scholar databases, with the keywords, “IHC in salivary gland tumors” and “immunohistochemistry in salivary gland tumors.” We excluded non-peer-reviewed articles, non-human studies, case reports, and series, and articles that were not in English or those for which the full text was not available; we included the remaining 18 articles in our qualitative data synthesis. To summarize the management strategy, we collated and included the key points from the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (Head and Neck Cancers, Version 1), 2023 and the American Society of Clinical Oncology guidelines. Our findings reflect that IHC markers, in addition to offering significant prognostic insight and guiding surgical strategy, also help plan hormonal and targeted therapies. A thorough understanding of the clinical implications of various IHC markers ensures informed multidisciplinary communication and helps the clinician and pathologist see things from a common perspective, that is, through the same lens.

Erosion is the main problem that affects soil health related to agricultural activities, therefore this study aims to determine the level of erosion hazard in the Jenelata Sub Watershed. RUSLE is used to calculate erosion prediction using rainfall erosion information, soil erodibility value, topographic value and using maps for vegetation and conservation practices, so that erosion values are obtained for Buakkang, Bissoloro, Bontomanai, Jenebatu, Sapaya Village, Paranglompoa, Pattalikang, Tassese, Mangempeng, Paladigan, and Ronaloe. Each was divided into very low classes with land loss of less than 15 t/ha/year with a land area of 7812.38 ha. The low class was land loss of 15 to 60 t/ha/year with a land area of 3263.04 ha. The medium class was land loss of 60 to 180 t/ha/year with a land area of 694.76 ha. The high class was land loss of 180 to 480 t/ha/year with a land area of 3234.03 ha, and the very high class was land loss that is greater than 480 t/ha/year with a land area of 5272.67 ha. This study showed high and very high erosion with a land area of 3234.03 ha and 5272.67 ha and very low erosion with a land area of 7812.38 ha.

Abstract Background Hypertrophic cardiomyopathy (HCM) is a hereditary myocardial disorder, often due to sarcomere gene mutations, characterized by the left ventricular hypertrophy. Current treatments offer symptomatic relief but lack specificity. Mavacamten, an allosteric inhibitor, has shown significant improvements in HCM patients in trials, reducing the requirement for invasive treatments. This meta-analysis assesses Mavacamten’s efficacy and safety as a targeted HCM intervention. Methods This study examined four randomized controlled trials comparing Mavacamten to placebo in HCM patients. Each trial had a unique primary endpoint, and secondary outcomes included improvements in NYHA-FC, eligibility for septal reduction therapy (SRT) or undergoing it, adverse events (serious and treatment-related), atrial fibrillation, and non-sustained ventricular tachycardia. Statistical analysis involved calculating risk ratios (RRs) and assessing heterogeneity. Results The four included studies showed minimal risk of bias and involved 503 patients with HCM (273 Mavacamten and 230 placebo). Mavacamten significantly increased the primary endpoint (RR 2.15, 95% CI 1.20–3.86, P = 0.01) and ≥ 1 NYHA-FC class (RR 2.21, 95% CI 1.48–3.3, P = 0.0001). Mavacamten group had lower rates of SRT compared to those receiving placebo (RR, 0.30, 95% CI 0.22–0.40; P

الملخص: أهداف البحث: حب الشباب الشائع مشكلة شائعة، مع معدل حدوث مرتفع نسبيا بين الآسيويين. بالمناسبة، تم إثبات الخصائص المحتملة المضادة للميكروبات والمضادة للالتهابات لقشور الموز في دراسات سابقة؛ ومع ذلك، لم يتم دراستها في حالة حب الشباب. هدفت الدراسة الحالية إلى معرفة التأثيرات الوقائية لمستخلص قشر الموز (موسى بالبسيانا) بسبب حب الشباب. طريقة البحث: تم تقسيم ثلاثين جرذا إلى خمس مجموعات (عدد = 6 فئران في كل مجموعة): مجموعة حب الشباب، مجموعة حب الشباب الشائع المعالجة بـ 0.15 ٪ قشر الموز (موسى بالبيسيانا) ، مجموعة حب الشباب الشائع المعالجة بنسبة 0.30 ٪ قشر الموز (موسى بالبيسيانا)، مجموعة حب الشباب الشائع المعالجة 0.60 ٪ قشر الموز (موسى بالبيسيانا)، وحب الشباب الشائع المجموعة التي تم إعطاؤها الكليندامايسين كدواء قياسي. قمنا بتقييم حجم العقيدات وعدد البكتيريا وعلم الأنسجة ومستويات السيتوكين (انترليوكن-1، وانتر فيرون جاما، وعامل نخر العظم-ألفا، انترليوكن-8). تم استخدام المقايسات المناعية المرتبطة بالإنزيم لقياس مستويات السيتوكين. بالإضافة إلى ذلك، أجرينا دراسات الالتحام الجزيئي لتحديد التفاعلات بين المواد الكيميائية النباتية (تريغونيلين، الفانيلين، حمض الفيروليك، حمض الأيزوفانيليك، الروتين، والسالسولينول) عبر مسارات المستقبل الشبيه بالتول-2 والعامل النووي – كابا ب. النتائج: أدت جميع جرعات قشر الموز (موسى بالبيسيانا) إلى تثبيط نمو البكتيريا وإنتاج السيتوكينات المنشطة للالتهابات مقارنة بمجموعة حب الشباب، بالإضافة إلى علاج التهاب الأنسجة. تم قمع حجم العقدة بشكل معنوي بأعلى جرعتين من قشر الموز (موسى بالبيسيانا) مقارنة بمجموعة حب الشباب. ومع ذلك، يظل تأثيره الدوائي أدنى من تأثير الكليندامايسين. أظهرت دراسات الالتحام أن المركب النباتي ذو الطاقة التفاعلية الأكثر سلبية مع المستقبل الشبيه بالتول-2 والعامل النووي – كابا ب كان روتيني. الاستنتاجات: تشير هذه النتائج إلى أن مستخلص قشر الموز (موسى بالبيسيانا) يعمل كعامل مضاد للالتهابات ضد حب الشباب الشائع، عن طريق قمع تكوينات العقيدات، وتثبيط نمو البكتيريا، وتقليل إنتاج السيتوكينات المسببة للالتهابات. Abstract: Objective: Acne vulgaris (AV) is a common problem with a relatively high incidence rate among Asian people. The potential antimicrobial and anti-inflammatory properties of banana peels have been demonstrated in previous studies but have not been studied in cases of AV. Therefore, this study was aimed at investigating the protective effects of banana (Musa balbisiana) peel extract (MBPE) against AV. Methods: Thirty rats were divided into five groups (n = 6 rats per group): an AV group, AV group treated with 0.15% MBPE, AV group administered 0.30% MBPE, AV group administered 0.60% MBPE, and AV group administered clindamycin (the standard drug treatment). We assessed nodule size, bacterial count, histopathology, and cytokine levels (IL-1α, IFN-γ, tumor necrosis factor (TNF)-α, and IL-8). Enzyme linked immunoassays were used to measure the cytokine levels. In addition, we performed molecular docking studies to determine the interactions between phytochemicals (trigonelline, vanillin, ferulic acid, isovanillic acid, rutin, and salsolinol) via the Toll-like receptor 2 (TLR2) and nuclear factor-kappa B (NF-κB) pathways. Results: All MBPE treatment groups, compared with the AV group, showed suppression of both bacterial growth and proinflammatory cytokine production, as well as resolved tissue inflammation. The nodule size was significantly suppressed in the groups receiving the two highest doses of MBPE, compared with the AV group. However, the pharmacological action of MBPE remained inferior to that of clindamycin. Docking studies demonstrated that rutin was the phytocompound with the most negative interaction energy with TLR2 or NF-κB. Conclusions: Our results indicated that MBPE has anti-inflammatory effects against AV, by suppressing nodule formation, inhibiting bacterial growth, and decreasing proinflammatory cytokine production.

This study is a qualitative descriptive research that focuses on integrating Inquiry-Based Learning (IBL) into the teaching of English in elementary schools in Indonesia. The research methodology includes interviews with teachers, classroom observations, and analysis of curriculum documents. The aim is to explore the challenges, experiences, and perceptions of implementing IBL approaches. It highlights the potential benefits of IBL, such as increased student engagement and language proficiency, but also identifies challenges, such as limited resources and varying levels of teacher readiness. The research emphasizes the importance of addressing these challenges while leveraging the potential benefits of IBL to create enriching learning experiences for students. The study's practical implications are discussed, focusing on enhancing English instruction practices in elementary schools. It emphasizes the need for comprehensive professional development, supportive classroom environments, and curriculum alignment. This research provides insights into IBL implementation in the Indonesian context and contributes to the ongoing discourse on effective English language education.

IntroductionStroke is a significant global health concern, and numerous studies have established a link between depression and an increased risk of stroke. While many investigations explore this link, some overlook its long-term effects. Depression may elevate stroke risk through physiological pathways involving nervous system changes and inflammation. This systematic review and meta-analysis aimed to assess the association between depression and stroke.MethodologyWe conducted a comprehensive search of electronic databases (PubMed, Embase, Scopus, and PsycINFO) from inception to 9 April 2023, following the Preferred Reporting Items for Systemic Review and Meta-analysis (PRISMA) and Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. We included all articles assessing the association between different stroke types and depression, excluding post-stroke depression. Two investigators independently extracted data and assessed quality using the Newcastle–Ottawa Scale and Cochrane Risk of Bias tool, utilizing a random-effects model for data synthesis. The primary outcome was the association of depression with stroke, with a secondary focus on the association of antidepressants with stroke.ResultsThe initial search yielded 10,091 articles, and 44 studies were included in the meta-analysis. The pooled analysis revealed a significant association between depression and stroke risk, with an overall hazard ratio of 1.41 (95% CI 1.32, 1.50; p

The purpose of this study is to determine the Implementation of the Inside Outside Circle Cooperative Learning Model on Pythagorean Theorem Material for Students of SMP Negeri 13 Banda Aceh. The method used in this study is a quasi-experimental research method. The research design used was one group pre test-post test design. This research was conducted at SMP Negeri 13 Banda Aceh and was carried out on December 11, 2023 in class VIII in the odd semester of the 2022/2023 academic year. The population in this study was all 31 students of Class VIII SMP Negeri 13 Banda Aceh. While the sample is class VIII-5 consisting of 31 students. Most students obtained grades greater than or equal to KKM scores, with an average score of 87.56. From the analysis of the t test, it was calculated that it was 3.82 greater than the table t. This shows that the Inside Outside Circle model affects the learning outcomes of Pythagorean Theorem material for grade VIII students of SMPN 13 Banda Aceh. The implementation of the Inside Outside Circle Cooperative Learning Model on the Pythagorean Theorem material grade VIII SMPN 13 Banda Aceh achieved maximum learning completeness. This model is very good to be applied to the teaching and learning process, because it can stimulate students to concentrate on the material being studied

Timor deer breeding activities as a type of animal that has economic value have been widely carried out in Indonesia. However, management in the form of determining harvest quotas that affect the feasibility of business is still minimal in various captive Timor deer in Indonesia.The objective of this research were to determine the harvest quota of timor deer and finansial feasibility of cavtive breeding of Sadhana Arifnusa. The harvest quota which is carried out once a year is determined based on the calculation of the break even point (BEP). The scenario of harvesting twice a year is based on the growth rate, and population harvesting rate. Financial feasibility is measured based on investment appraisal criteria, namely Net Present Value, Benefit Cost Ratio, Internal Rate of Return, and Payback Period. The result revealed that the harvest quota which is carried out once a year were 5 individuals, population size that must be available at the time of harvest is 48 individuals. Meanwhile, the harvest quota that is carried out twice a year from year 1 to year 3 is 2 individuals. Based on the financial value of the scheme without slaughter and the scheme with slaughter, it can be said that the timor deer captive business potentially profitable and feasible to develop with NPV values ​​of Rp. 428,748,935 and Rp. 934,136,423 respectively; BCR value respectively 1.66 and 2.46; IRR value of 28.89% and 32.89% respectively, and ability to return investment after 4.6 years and 5.1 years.

The mangrove ecosystem of Lusi Sidoarjo Island has uniqueness and beauty with great potential to be developed as an education and conservation-based tourism. The main step that can be taken in efforts to develop mangrove tourism is identifying regional conditions and potentials through carrying capacity analysis. Carrying capacity analysis is needed to anticipate excess visitors who can potentially cause damage to the tourism environment. This study carried out in June – July 2022, aimed to analyze the potential and carrying capacity of mangrove ecosystems on Lusi Island as an education and conservation-based tourism. The method used in this study is descriptive quantitative by collecting data through observation, interviews, and field surveys. The calculation was made to determine the carrying capacity of the area. The results showed that the area's carrying capacity was 360 visitors/day with a diverse potential for mangroves, flora, fauna, and abundant content of metals and minerals based on XRD and XRF analysis, and literature studies. Based on the results of the analysis, it can be interpreted that Lusi Sidoarjo Island has a great amount of potential to be developed as an education and conservation-based tourism.

Freshwater fisheries product tilapia (Oreochromis niloticus) has the potential to be developed and has a very high economic value, particularly in the city of Tarakan. Fish ectoparasites are a problem that frequently occurs and is discovered in aquaculture. This study aimed to determine the type of ectoparasites that infect tilapia in aquaculture ponds in Kampung Satu and Sebengkok. The technique involved collecting tilapia samples from various ponds and then transporting them to the laboratory. A total of 30 samples were taken from the container that was set up on a tray, and they were all put to death by being stabbed in the brain nerves. It was done to identify ectoparasites on the gills, eyes, scales, and fins of the fish. Two forms of ectoparasites, Dactylogyrus sp. and Trichodina sp., which were only present in the gills, were identified in the tilapia. In the moderate infection group, the prevalence rate in Kampung Satu was 86%, and in the very frequent infection category, it was 66% in Sebengkok. In Kampung Satu, the level of ectoparasites was 3,84, which is considered low, and 8,30, which is considered medium, in Sebengkok.

Abstract Background Iron deficiency can impair immune function, increasing tuberculosis (TB) susceptibility and severity. The research aimed to investigate iron deficiency anemia in TB patients and household contacts and its association with natural resistance‐associated macrophage protein 1 (NRAMP1) polymorphism and expression. Methods The levels of iron, ferritin, and transferrin were measured in the serum by ELISA (Enzyme‐Linked Immunosorbent Assay). NRAMP1 polymorphisms were determined by polymerase chain reaction (PCR) and sequencing. NRAMP1 gene expression was measured by real‐time PCR. Interferon‐gamma release assay (IGRA) checked on household contacts to screen household contacts with positive IGRA as the control. Results This study involved 35 TB cases and 35 TB contacts. The results showed that the serum Fe levels were found to be lower in the TB case group (median 149.6 μmol/L) than in the positive IGRA household contacts group (median 628.53 μmol/L) with a p‐value

Despite availability of strategies against viral hepatitis, it is still a serious disease, which millions of people are already infected with, hence it yet needs to be focused on. As an attempt, we formulated a single mathematical model describing behaviour of all strains of viral hepatitis, presented in the literature. The basic reproduction number(R_0) at disease free equilibrium point is computed, feasible region has been determined. For local stability of the model, R_0 has been taken into account and for global stability of the model Lyapunov method is followed. The model is then applied to the data available for Afghanistan for the year 2020. Based on the data, values of the parameters are estimated, using Minimum Mean Absolute Error (MAE) method. Numerical simulation is performed to support the model and then the results are plotted and represented graphically. One-at-a-time sensitivity analysis (OAT) method is used for sensitivity analysis and involved parameters have been examined for the propose of sensitivity analysis, it indicated that infection rates of acute and chronic states of viral hepatitis are the most sensitive and critical parameters. It has been observed that large number of populations can become infected followed by small increment of infection rates. It has also been noticed that, entire population of Afghanistan could become infected, if no prevention measures were taken. The model presented in this paper is useful for forecasting outbreak by viral hepatitis and it can further be modified by including prevention measures.

This study aims to analyze the addition of the minimum age limit for marriage in law No. 16 of 2019 and its relevance to efforts to suppress requests for marital dispensation. This study used the library research method with a statutory and conceptual approach. The results of the study show that the formulation of changes to the minimum age limit for marriage in Law Number 16 of 2019 has implemented efforts to prevent early marriage. If viewed from the perspective of hikmatut tasyri', it contains an affirmation that the change represents the maintenance of maqashid sharia. Efforts to increase the minimum age limit for marriage are closely related to the impact of the surge in marriage dispensations received by the religious courts. The marriage dispensation actually applies to legal subjects who do not meet the minimum age criteria and if this minimum age limit is changed to a higher one, the relevance of the dispensation application will also increase. It can be seen that efforts to prevent early marriage are realized in the implementation of the minimum age limit, but the agenda of minimizing dispensation is the responsibility of justice enforcers, namely the panel of judges. Considerations given in the marriage dispensation judicial process are expected to prioritize physical, mental, sociological, and economic conditions.

BackgroundThis study addresses the pervasive issue of heightened preoperative anxiety in healthcare, particularly among pediatric patients. Recognizing the various sources of anxiety, we explored both pharmacological and nonpharmacological interventions. Focusing on distraction techniques, including active and passive forms, our meta-analysis aimed to provide comprehensive insights into their impact on preoperative anxiety in pediatric patients.MethodsFollowing the PRISMA and Cochrane guidelines, this meta-analysis and systematic review assessed the efficacy of pharmaceutical and distraction interventions in reducing pain and anxiety in pediatric surgery. This study was registered on PROSPERO (CRD42023449979).ResultsThis meta-analysis, comprising 45 studies, investigated pharmaceutical interventions and distraction tactics in pediatric surgery. Risk of bias assessment revealed undisclosed risks in performance and detection bias. Distraction interventions significantly reduced preoperative anxiety compared to control groups, with notable heterogeneity. Comparison with Midazolam favored distraction techniques. Subgroup analysis highlighted varied efficacies among distraction methods, with a notable reduction in anxiety levels. Sensitivity analysis indicated stable results. However, publication bias was observed, suggesting a potential reporting bias.ConclusionOur study confirms distraction techniques as safe and effective for reducing pediatric preoperative anxiety, offering a valuable alternative to pharmacological interventions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=449979, PROSPERO [CRD42023449979].

Actinomycosis is a rare, chronic, and suppurative disease caused by Actinomyces species, which are filamentous, obligate, Gram-positive bacteria. This report presents a case of anterior abdominal actinomycosis in a 40-year-old female with a history of intrauterine contraceptive device placement. The patient presented with severe abdominal pain, an abdominal mass, low-grade fever, and weight loss. Imaging studies revealed thickening of the left rectus abdominis muscle and pericolic fat stranding. An exploratory laparotomy confirmed dense adhesions from the transverse colon and omentum to the abdominal wall with a purulent discharge. Resection of the affected colon segment and primary anastomosis were performed. Histopathological examination revealed characteristic colonies of Actinomyces within abscesses, confirming the diagnosis of actinomycosis. The patient received appropriate antibiotic therapy and showed improvement. This case highlights the rare occurrence of abdominal wall actinomycosis associated with an intrauterine contraceptive device and emphasizes the importance of considering actinomycosis in the differential diagnosis of abdominal pathologies. Thus, medical history related to intrauterine contraceptive device use should be regarded as in differentials if a patient presents vague abdominal mass and pain, and small details in history should be emphasized and looked upon so that a timely decision can be made for the betterment of the patient.

The research aimed to identify potential words in the Indonesian language and sought to explain why these words were not included in Indonesian vocabulary lists or were difficult to realize in natural conversations. In order to achieve these goals, data were collected using introspection, documentation, and interview methods. Furthermore, the collected data were analyzed using a generative morphology approach, mainly related to concepts of potential words. According to the approach, each language has (1) a List of Morphemes (LM), (2) Word Formation Rules (WFR), and (3) a Filter (F). WFR stated that every language was capable of producing new potential words, yet not all those potential words could easily pass through the filter to enter the lexicon of actual words used in real life. The potential words discussed in the research were restricted to those showing morpho-syntactic interconnection among Indonesian affixes. The results indicate that numerous potential words in the Indonesian language are constructed out of such affixal interconnection. However, the potential words do not surface in the lexicon for two reasons: first, because the words fail to compete with others that compensate for their absence; second, because the words are difficult to manifest due to their low frequency in everyday speech.

The harmful effects of exposure to light (UV) can be prevented by using sunscreen. This study aims to determine the best formulation contained in various herbal plants to be used as a manufacturing material sunscreen. The method in this study is the study of literature from the research journal database on the internet, namely through google scholar and Proquest University of Mataram. Sunscreens are assessed in terms of light protection factor expressed by the SPF value (Sun Protection Factor) to determine the effectiveness of sunscreen preparations or the ability to withstand UV rays. Several types of herbal plants that grow in various regions in Indonesia contain photoprotective bioactive compounds. Aromatic ginger (Kaempferia galanga L.) is a herbal plant widely used as an ingredient in sunscreens with a high protection category. Cinnamic derivatives, namely ethyl para-methoxycinnamate (EPMS), are one of the compounds contained in aromatic ginger and can be used as a manufacturing material sunscreen that is good and safe for the skin.

The movement of a company can’t be separated from resources owned by the company. In this case, the success of a company is strongly supported by the human resources in it. Good work management in a company can be reflected in the creation of a balance between labor productivity and the demands of the company's progress. Therefore, this research aims to analyze internal and external factors related to the productivity of plantation employees in the agroindustrial company engaged in the production and largest pineapple exporter in Indonesia, PT. Great Giant Pineapple. This research also aims to analyze factors most influence productivity of plantation employees. This research was conducted by taking data from 220 respondents of plantation employees using the convenience technique method. Furthermore, data processing and validity and reliability test were carried out using SPSS 17 Ver 25.0, and quantitative tests were processed using SmartPLS to analyze the structural equation model using SEM-PLS. Based on the result, there are six factors that influence the productivity of plantation employees: motivation, competence, work environment, discipline, work quality, and incentive, which are then tested on employee productivity factors. The factor of motivation, competence, discipline, work quality, and incentive have a significant effect on the productivity of employees, while the work environment factor has an insignificant effect on the productivity of employees.

The aim of this study is to determine what types of psychological factors sixth-semester EFL higher education students confront when speaking English and how to overcome these psychological factors. This study employs qualitative descriptive methods with two variables. This research used the technique of purposive sampling to select participants, in which volunteers are chosen based on the criteria and objectives of the study. In this study, twenty 2019 Academic Foreign Language Student of the Sixth Semester participated. This research employed qualitative data analysis techniques (questionnaire). The score assigned to each student as a result. Using the Likert Scale Procedure, the data obtained from this study were analyzed. The findings revealed that the majority of students are affected by the same psychological factors, namely Anxiety, Lack of Self-Confidence, Fear, and Shyness. The majority of students are terrified of speaking English. They experience discomfort and agitation if they are required to answer or ask questions in English. Also, the results demonstrated that the sixth-semester ABA UMI class of 2019 possessed an extremely high degree of motivation. This is where they feel that learning English is crucial, since they are constantly asking their professors and peers about subjects they do not understand, and their desire to learn in English is quite strong. The study suggests that educators should focus on enhancing students' psychological factors, particularly motivation, anxiety, and self-confidence, to improve their speaking performance in the EFL classroom. The findings of this study contribute to the body of knowledge on the impact of psychological factors on EFL learners' speaking skills, and can help educators develop effective strategies to improve their students' speaking proficiency in the EFL classroom.

The proximity of the Macaca fascicularis habitat to locations of human activity, especially in the IPB University area, disrupts human activity, especially in the morning and evening. The act of Maccaca fascicularis entering human territory increases the potential for human conflict with Macaca fascicularis. This research aims to identify the variables that cause conflict in the IPB Dramaga Campus environment by describing the intensity of influence and interdependent relationships between variables and grouping them from the most influential to the least influential. This research was conducted at IPB University, Bogor, Indonesia in 2021. The object of this research was the Macaca fascicularis group located at the IPB Dramaga Campus. Data collection was carried out by applying the Focus Group Discussion method to determine the influencing variables and human conflict with Macaca fascicularis. Data analysis was carried out using the Micmac Method. Based on the research results, there are factors that influence food, vegetation, culture, and the important role of human activity, land, population, and mitigation. The Primate Animal Study Center (PSSP) in collaboration with the Bogor BKSDA is making efforts to overcome disturbances using the Trapping Cage method, which is a method carried out by storing iron cages filled with fruit such as bananas and others in several locations that are suspected to be frequently visited areas and Increase the active role of the community around the IPB campus which is affected by long-tailed monkeys by providing incentives for people who are able to catch long-tailed monkeys without causing harm.

A 48-year-old male with a large histologically proven leiomyosarcoma of the left upper lip underwent wide local excision and local advancement flap reconstruction, without adjunctive radiation or chemotherapy. A review of the literature reveals the need for standardised criteria in the diagnosis of leiomyosarcoma by histopathological features.

Abstract The potential impact of autonomous robots on everyday life is evident in emerging applications such as precision agriculture, search and rescue, and infrastructure inspection. However, such applications necessitate operation in unknown and unstructured environments with a broad and sophisticated set of objectives, all under strict computation and power limitations. We therefore argue that the computational kernels enabling robotic autonomy must be scheduled and optimized to guarantee timely and correct behavior, while allowing for reconfiguration of scheduling parameters at runtime. In this paper, we consider a necessary first step towards this goal of computational awareness in autonomous robots: an empirical study of a base set of computational kernels from the resource management perspective. Specifically, we conduct a data-driven study of the timing, power, and memory performance of kernels for localization and mapping, path planning, task allocation, depth estimation, and optical flow, across three embedded computing platforms. We profile and analyze these kernels to provide insight into scheduling and dynamic resource management for computation-aware autonomous robots. Notably, our results show that there is a correlation of kernel performance with a robot’s operational environment, justifying the notion of computation-aware robots and why our work is a crucial step towards this goal.

The agribusiness program is one of the Cigombong TTP programs that can help assisted farmers and breeders and partners market their products at a better price. This study aims (1) to analyze the consumer decision-making process for the Cigombong TTP agribusiness program and (2) to analyze the consumer satisfaction of the Cigombong TTP agribusiness program product. The method used is descriptive analysis, Customer Satisfaction Index (CSI) and Importance Performance Analysis (IPA). The results showed that the decision-making process of most consumers of the TTP Cigombong agribusiness program was motivated to get quality products, sought information from family or friends, the most interesting promotions were product quality, considering product purchases as needed, making planned purchases regularly every week. once and expressed satisfaction after purchasing the TTP Cigombong agribusiness program product. Based on CSI analysis, consumers are satisfied with the performance of the TTP Cigombong agribusiness program with a value of 79.19% and the priority attributes to be repaired according to the IPA matrix are the attributes of security assurance or product certification.

Improvements in technology have led to further enhancements in cyber security threats. Additionally, the mass application of IoT technology and networks has made the ecosystem vulnerable to cyber-attacks. Thus, this study focuses on analysing methods to enhance the security and privacy of IoT devices and networks against cyber threats/AI through a primary quantitative method. The methodology section looks into different factors associated with the development of the study. In order to analyse cyber security, a primary quantitative method is employed. It is found that factors such as data security protocol, type of IoT device, users’ precautions, and regulatory policy are related to the security measures of the study. The discussion section briefly considers the findings of the study. Moreover, detailed observation can be found in the discussion section of the study.

BACKGROUND: Extra Virgin Olive Oil (EVOO) is a fat source classified as monounsaturated fatty acid. Previous studies have shown that 47.5% of breastfeeding mothers have less fat intake when compared to the Adequacy of Nutrition Rate (RDA). EVOO consumption can improve the composition of breast milk. However, no research has been found regarding the body composition of breastfeeding mothers after consuming EVOO. This study aims to determine the effect of EVOO on the body composition of breastfeeding mothers 0-24 months. MATERIALS AND METHODS: The study was conducted at the Sudiang Raya and Tamalanrea Health Centers in Makassar City with a randomized clinical trial design from January to February 2023. The sample was breastfeeding mothers 0-24 months divided into the intervention group (EVOO and Nutrition Education, n = 17) and the control (Nutrition Education, n = 17). Instruments with Bioelectrical Impedence Analysis tools. Data analysis using t-test. RESULTS: The sample is breastfeeding mothers aged between ≤19 and >35 years. The results of the analysis showed that the average pre-post test, % fat mass (FM) P = 0.426 and % fat free mass (FFM) P = 0.508 (P > 0.05), meant that there was no significant difference. Between the two groups there was no significant difference at the end of the study, %FM P = 0.469 and %FFM P = 0.529 (P > 0.05). CONCLUSIONS: In the intervention group that was given EVOO, it was possible to maintain%FM and%FFM in the normal percentage range, while in the control group, there was a decrease from the normal to less/low range.

Abstract Background Hypertension, a leading cause of global mortality and morbidity, affects approximately 1.28 billion adults worldwide, with most cases occurring in low- and middle-income countries. Despite several methods for managing mild to moderate hypertension, effective management of severe or resistant hypertension remains challenging. Renal denervation, a promising non-pharmacological technique, has emerged as a potential solution. Main body Renal denervation works by modifying the renal sympathetic nerve supply through techniques such as ultrasound, radiofrequency energy, or injection of neurolytic agents, reducing blood pressure. Clinical trials, including the RADIANCE series, have shown consistent effectiveness of ultrasound renal denervation in lowering blood pressure, especially in patients who were previously unresponsive to anti-hypertensive medications. After a follow-up of 2 months, mean ambulatory systolic blood pressure during the daytime decreased significantly in the ultrasound renal denervation group compared to the sham group. However, further research is needed to determine renal denervation's long-term safety and efficacy. Conclusions In conclusion, renal denervation holds great potential in improving the treatment of uncontrolled or resistant hypertension treatment, but more investigations and trials are necessary to establish its effectiveness and safety.

Purpose: To prove the effect of Miana (M), Quercetin (Q), and the combination as an anti-inflammatory agent and Cefixime (C) as an antibiotic in Balb/c mice infected with Salmonella enterica serovar Typhi (S. Typhi) and related to the dynamics of NF-κB mRNA expression and NF-κB protein levels. Methods: A cohort study on male Balb/c mice with subjects consisted of 8 groups with 5 each group by administration of M, Q, M + Q, M + C, Q + C, M + Q + C, C only and sterile distilled water group as negative control. The statistical significance of the difference group was defined as P values less than 0.05. Results: Decreased mRNA expression of NF-κB, NF-κB protein levels, and bacterial load after administration of M + C, Q + C, or M + Q + C showed significant differences when compared to the negative control. The decline in NF-κB was stronger when M + Q + C was given compared to M, Q, M + Q, or C only. Conclusion: The effects of NF-κB suppression appear to be the same between the administration of M, Q and the M + Q when C added. However, the suppression of NF-κB was not significant without adding C.

Lutung Sentarum (Presbytis Chrysomelas spp cruciger) is a member of the Presbyis tribe. Langur Sentarum (Presbytis Chrysomelas Cruciger) is one of the endemic animals in West Kalimantan with unprotected status, but is vulnerable to extinction. The study was conducted to obtain data on the demographic parameters of animal populations and their management in the Sepandan Resort area. The research was conducted through field observations to obtain data on demographic parameters with the concentration count method based on consideration of the characteristics of species distribution and field conditions in the research area. Population size data collection was carried out at 15 observation points, which were spread across all habitats types in the research study area. Observations or population size calculations at one point were carried out three times, namely in the morning (06.00 – 08.00), afternoon (12.00 – 14.00) and afternoon (16.00 – 18.00), and three replicates were carried out. The results of data from Lutung sentarum at the Sepandan resort found 8 groups from 2 areas, namely in Pelaik hamlet 2 groups and in Kedungkang hamlet 6 groups. Each group relatively had 1 adult male. Total individuals found were 58 individuals consisting of: 8 adult males, 25 adult females, 5 juvenile males, 18 juvenile females and 2 chicks. The total number of adult males and juveniles is 13 individuals and the total number of females is 43 individuals. The results in the sex ratio calculation of the encounter of 8 groups consisting of 13 males and 43 females were composed of sex ratio values of 1: 3. Total natality value of 8 groups of langur sentarum is 0.08.

The headline is the main highlight that readers see in a news story. Tempodotco digitized its printed news headlines. The digitization of this news title is done by visualizing it in the form of a poster. The purpose of this study is to describe the semantic behavior of groups of basic verbs, derivative verbs, and verbal phrases in forming metaphors and personifications in news titles on the Tempodotco digital media Instagram page. This research method uses descriptive method. The data collection method is the method of listening and documentation. The type of data in this research is qualitative data in the form of pictures and words in the news title. Data analysis used the Miles and Huberman model which includes data analysis, data reduction, data display, and data verification. In this study, it was found that 1) the basic verb group has three inherent meanings of action or action and one inherent meaning of state. The language style formed is three metaphors and one personification. 2) The semantic behavior of the derived verb group which is transitive has five inherent meanings, one action inherent meaning, and one process inherent meaning. The language style formed is three metaphors and two personifications. 3) The semantic behavior of the verbal phrase group has all the inherent meanings of the action and forms three metaphors and one personification. In this study, there is no reduplication of the verb. Keywords: Title, Verb, Semantics, Metaphor, Personification, Phrase

The Public Service Innovation Network is a form of cooperation in the development of public service innovations that are run between related agencies, as an effort so that all parties are connected to each other in the development of public service innovations. This research is based on qualitative research method with descriptive type. Data were collected through interviews, observation and documentation. The data validation technique uses the theory of Miles & Huberman. The results of the research show that the implementation of the South Sulawesi JIPP is well implemented, with the ability to distribute the latest information with the support of a website that was created, as a learning tool and a data center for public service innovation information, and become a center for accelerating the quality of public services in the province of South Sulawesi so that a number of Regional Apparatus Organizations have succeeded. won an award at the Public Service Innovation Competition at the National level. The Public Service Innovation Network is a stakeholder collaboration node for the success of the one agency one innovation movement so that ultimately a creative climate is created to create public service innovations in the scope.

This research explains politeness in the Sumbawa ethnic language on social media, including the types of politeness that tend to be used. The politeness theories of Lakoff, Leech, Brown and Levinson, Grice, and Pranowo are the theories used to explain this. Data was collected using documentation methods through the use of language on social media sites such as Instagram, Facebook, and WhatsApp, either individually or in groups. The data was then analyzed using principles in pragmatic studies. The research results show that not all types of language politeness proposed by experts are used by the Sumbawa ethnic group. The politeness type of giving sympathy, showing agreement or similarity, giving praise, and avoiding arguments are the dominant types of politeness used with the person you are talking to. Comprehensive studies need to be carried out in all domains to obtain a politeness model for the Sumbawa ethnic language.

This study aims to determine the effect of Self-Regulated Learning (SRL) and motivation on laboratory activities of Chemistry Education students. Three theoretical hypotheses are proposed, namely (1) SRL has a direct effect on laboratory activities of Chemistry Education students; (2) SRL has a direct effect on the motivation of chemistry education students; and (3) SRL has an indirect effect on laboratory activities through motivation as a mediator. The instrument was a questionnaire distributed to respondents totaling 268 chemistry education students. Filling out the questionnaire is carried out after students have carried out practicum for one semester. The research results show that SRL has a significant effect on laboratory activities and motivation. The influence of motivation as an intervening SRL was found to be insignificant on laboratory activities.

Kesehatan harus dilihat sebagai investasi dalam peningkatan kualitas Sumber daya manusia berperan penting dan ketika pandemi virus Covid-19 masih terjadi di seluruh dunia, termasuk di Indonesia. Kearifan lokal yang tumbuh dan dapat ditemukan nilai kebenarannya berdasarkan berbagai fakta yang berlaku secara spesifik di lingkungan budaya masyarakat. Dalam upaya memelihara kesehatan dan menjaga kebersihan lingkungan maupun warganya, kearifan lokal masyarakat pedesaan di Jawa dapat ditiru. Dengan mencuci tangan merupakan strategi yang dikatakan sangat efektif dalam mencegah penyebaran infeksi virus corona.Metode pengumpulan data penelitian ini diambil dari sumber data. Sumber yang digunakan antara lain buku teks, jurnal ilmiah, bahan referensi statistik, hasil penelitian dan sumber lain yang terkait. Jenis penelitian yang digunakan dalam penelitian ini yaitu penelitian kepustakaan yang berisi tentang teori-teori yang berkaitan dengan pertanyaan penelitian. Berdasarkan pembahasan maka dapat disimpulkan bahwa Kampanye cuci tangan pakai sabun terus dilakukan di tengah pandemi. Padahal, gerakan cuci tangan terbukti dapat meminimalkan risiko penyakit. Namun, karena pandemi cuci tangan pakai sabun sudah menjadi kebiasaan yang harus dimiliki karena diyakini bisa menurunkan kasus Covid-19. Padasan adalah solusi yang dapat dilestarikan kembali di setiap rumah agar kembali menjadi budaya, ikhtiar yang sehat. Padasan tidak selalu harus dalam bentuk ember tanah liat, memiliki keran di depan rumah dengan sabun tangan adalah salah satu bentuk upaya kami untuk mencegah penyebaran virus.

Pendapatan Usaha Mikro dan Kecil bidang Kuliner di Banjarbaru pada tahun 2015-2019 mengalami peningkatan. Perkembangan usaha dapat dipengaruhi oleh kompetensi kewirausahan dan faktor eksternal. Tujuan penelitian ini adalah menganalisis pengaruh karakteristik individu dan karakteristik psikologi terhadap kompetensi kewirausahaan, pengaruh kompetensi kewirausahaan dan faktor eksternal terhadap kinerja usaha, dan pengaruh faktor eksternal terhadap kompetensi kewirausahaan. Penelitian ini dilakukan dengan menggunakan teknik survei. Alat analisis data menggunakan SEM. Sampel pada penelitian ini sebanyak 210. Metode pengumpulan data dilakukan dengan wawancara langsung dan google form melalui whatssapp responden. Hasil penelitian menunjukkan bahwa wirausaha yang ulet dan memiliki motivasi yang tinggi maka kompetensi kewirausahaan tinggi. Wirausaha yang memiliki kemampuan teknik yang tinggi maka kinerja usaha tinggi. Wirausaha yang memiliki jaringan sosial yang banyak maka kinerja usaha tinggi. Kesimpulan pada penelitian ini adalah karakteristik individu dan karakteristik psikologi berpengaruh positif terhadap kompetensi kewirausahaan, kompetensi kewirausahaan dan faktor eksternal berpengaruh positif terhadap kinerja usaha.

Permasalahan yang akan diangkat dalam program pengabdian kepada masyarakat ini adalah pengelolaan sumber daya alam atau potensi yang dimiliki Desa Margahayu. Program Pengabdian kepada Masyarakat ini bertujuan untuk memberikan platform informasi potensi yang dimiliki Desa Margahayu agar masyarakat luar dapat mengenal Desa Margahayu lebih jauh. Program Pengabdian kepada Masyarakat dilaksanakan di Desa Margahayu dengan metode (1) tatap muka/tatap maya, (2) pertemuan perwakilan antar desa, (3) pandangan jarak jauh (eagle’s eye), (4) diskusi dengan tokoh masyarakat dan (5) observasi. Langkah-langkah yang dilakukan dalam penyelesaian masalah ini yaitu pembuatan website dan video profil desa, pembuatan video tutorial pupuk dan pengolahan jahe, pembelajaran les Bahasa inggris secara online serta pembuatan X Banner dan spanduk mengenai Covid-19. Diharapkan program kerja pengabdian kepada masyarakat ini dapat bermanfaat bagi pihak dan masyarakat Desa Margahayu

This paper aims to discuss the pattern of resolution of the Ambon conflict that occurred in 1999-2002 and was caused by various complex factors. This study offers a conflict resolution approach using the so-called BakuBae theology, which is based on religious values and local wisdom. In this qualitative research, the author deals with the theme from the perspectives of theology, history, and culture, and uses convergence as the theme point. This study found that the dynamics of the Ambon conflict had a multi-dimensional background (political, economic, social, and cultural). The pattern of conflict resolution using a top-down approach to the security aspect, namely the role of the TNI-Polri institutions, which tend to be repressive, has caused the division of social and religious identities between Salam-Sarane (Islam-Christian) in Ambon. This actually complicates the process of ending the conflict. On the other hand, the bottom-up approach of the BakuBae social movement has involved civil society and grassroots groups that play a significant role in conflict resolution. The program of BakuBae has become the right pattern for conflict resolution. The findings of BakuBae's work are the key to a solution to the conflict in Ambon.

Dairy cows are one of the strategic livestock in Indonesia. However, increased dairy demand, which exceeds domestic dairy production, increases dairy import quantity. As dairy import increases, import tariff as an import restriction policy can be used to protect the sustainability of domestic dairy production. This study aimed to investigate the impact of import tariff policy on dairy supply and demand in Indonesia. This study used secondary data obtained from various official institutions. Factors determining dairy supply and demand were estimated using two-stage least squares (2SLS), and the impact of import tariff policy was estimated using a simultaneous equation system model. The empirical results indicate that the import tariff policy has a positive impact on dairy supply and a negative impact on dairy demand. Import tariffs were a factor determining the positive impact on dairy production, dairy cow population, and domestic dairy prices. The import tariff policy also had a negative impact on decreasing the quantity of dairy imports. It is concluded that import tariffs could be an important dairy import restriction policy to protect domestic dairy production and dairy producers in Indonesia.