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200 results on '"Burdick, J."'

1. Mobile Robot Sensory Coverage in 2-D Environments: An Optimization Approach with Efficiency Bounds

Author

Fourney, E., Burdick, J. W., and Rimon, E. D.

Subjects
Computer Science - Robotics
Abstract

This paper considers three related mobile robot multi-target sensory coverage and inspection planning problems in 2-D environments. In the first problem, a mobile robot must find the shortest path to observe multiple targets with a limited range sensor in an obstacle free environment. In the second problem, the mobile robot must efficiently observe multiple targets while taking advantage of multi-target views in an obstacle free environment. The third problem considers multi-target sensory coverage in the presence of obstacles that obstruct sensor views of the targets. We show how all three problems can be formulated in a MINLP optimization framework. Because exact solutions to these problems are NP-hard, we introduce polynomial time approximation algorithms for each problem. These algorithms combine polynomial-time methods to approximate the optimal target sensing order, combined with efficient convex optimization methods that incorporate the constraints posed by the robot sensor footprint and obstacles in the environment. Importantly, we develop bounds that limit the gap between the exact and approximate solutions. Algorithms for all problems are fully implemented and illustrated with examples. Beyond the utility of our algorithms, the bounds derived in the paper contribute to the theory of optimal coverage planning algorithms.

Published
2024

9. 'An open secret': Public housing and downward raiding in Rio de Janeiro

Author

Garmany, J, Burdick, J, Garmany, J, and Burdick, J

Abstract

This article examines a case of urban displacement currently underway in central Rio de Janeiro, Brazil. In some respects, this case represents a classic example of what researchers call ‘downward raiding’: a type of urban displacement whereby low-income housing is exploited by higher-income groups. Yet, in other respects, it also raises important questions about the ways urban displacement happens in public housing, as well as how downward raiding operates on the ground in cities. By exploring these questions, this article aims to accomplish two goals: first, to investigate an overlooked and often hidden form of urban displacement that, in this case, coincides with a large-scale, public–private housing initiative; and, second, to critically interrogate the concept of downward raiding in order to better understand and define the process. It is argued that by placing greater emphasis on how, empirically speaking, urban displacement happens, researchers may gain new insight into diverse forms of urban displacement in cities around the world.

Published
2020

10. Correspondence : Burdick (Justin) and Engelmann (George), 1881-1882.

Author

Burdick, J. H. (Justin Herbert), 1851-1939, Missouri Botanical Garden, Peter H. Raven Library, and Burdick, J. H. (Justin Herbert), 1851-1939

Subjects
(Justin Herbert), Allium, Botanical specimens, Burdick, J. H, Correspondence, Engelmann, George, Identification, Letters, Liliaceae, Nevada
Published
1881

11. Correspondence : Burdick (Justin) and Engelmann (George), 1881-1882

Author

Burdick, J. H. (Justin Herbert), 1851-1939, Missouri Botanical Garden, Peter H. Raven Library, and Burdick, J. H. (Justin Herbert), 1851-1939

Subjects
(Justin Herbert), Allium, Botanical specimens, Burdick, J. H, Correspondence, Engelmann, George, Identification, Letters, Liliaceae, Nevada

16. A definition of bioinks and their distinction from biomaterial inks

Author

Groll, J., Burdick, J. A., Cho, D. W., Derby, B., Gelinsky, M., Heilshorn, S. C., Jüngst, T., Malda, J., Mironov, V. A., Nakayama, K., Ovsianikov, A., Sun, W., Takeuchi, S., Yoo, J. J., Woodfield, T. B.F., Groll, J., Burdick, J. A., Cho, D. W., Derby, B., Gelinsky, M., Heilshorn, S. C., Jüngst, T., Malda, J., Mironov, V. A., Nakayama, K., Ovsianikov, A., Sun, W., Takeuchi, S., Yoo, J. J., and Woodfield, T. B.F.

Published
2018

17. A definition of bioinks and their distinction from biomaterial inks

Author

LS Equine Muscoskeletal Biology, dES RMSC, Groll, J, Burdick, J A, Cho, D-W, Derby, B, Gelinsky, M, Heilshorn, S C, Jüngst, T, Malda, J, Mironov, V A, Nakayama, K, Ovsianikov, A, Sun, W, Takeuchi, S, Yoo, J J, Woodfield, T B F, LS Equine Muscoskeletal Biology, dES RMSC, Groll, J, Burdick, J A, Cho, D-W, Derby, B, Gelinsky, M, Heilshorn, S C, Jüngst, T, Malda, J, Mironov, V A, Nakayama, K, Ovsianikov, A, Sun, W, Takeuchi, S, Yoo, J J, and Woodfield, T B F

Published
2018

18. A definition of bioinks and their distinction from biomaterial inks

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Groll, J., Burdick, J. A., Cho, D. W., Derby, B., Gelinsky, M., Heilshorn, S. C., Jüngst, T., Malda, J., Mironov, V. A., Nakayama, K., Ovsianikov, A., Sun, W., Takeuchi, S., Yoo, J. J., Woodfield, T. B.F., Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Groll, J., Burdick, J. A., Cho, D. W., Derby, B., Gelinsky, M., Heilshorn, S. C., Jüngst, T., Malda, J., Mironov, V. A., Nakayama, K., Ovsianikov, A., Sun, W., Takeuchi, S., Yoo, J. J., and Woodfield, T. B.F.

Published
2018

19. A definition of bioinks and their distinction from biomaterial inks

Author

Groll, J, Burdick, J A, Cho, D-W, Derby, B, Gelinsky, M, Heilshorn, S C, Jüngst, T, Malda, J, Mironov, V A, Nakayama, K, Ovsianikov, A, Sun, W, Takeuchi, S, Yoo, J J, Woodfield, T B F, LS Equine Muscoskeletal Biology, dES RMSC, LS Equine Muscoskeletal Biology, and dES RMSC

Subjects
ResearchInstitutes_Networks_Beacons/MICRA, Computer science, Biomedical Engineering, Biocompatible Materials, Bioengineering, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Biomaterials, ddc:570, Animals, Humans, Dalton Nuclear Institute, ddc:610, Bioprinting, Biomaterial, General Medicine, 021001 nanoscience & nanotechnology, Biocompatible material, 0104 chemical sciences, ResearchInstitutes_Networks_Beacons/dalton_nuclear_institute, Manchester Institute for Collaborative Research on Ageing, Printing, Three-Dimensional, Ink, 0210 nano-technology, Biotechnology, Biofabrication
Abstract

Biofabrication aims to fabricate biologically functional products through bioprinting or bioassembly (Groll et al 2016 Biofabrication 8 013001). In biofabrication processes, cells are positioned at defined coordinates in three-dimensional space using automated and computer controlled techniques (Moroni et al 2018 Trends Biotechnol. 36 384-402), usually with the aid of biomaterials that are either (i) directly processed with the cells as suspensions/dispersions, (ii) deposited simultaneously in a separate printing process, or (iii) used as a transient support material. Materials that are suited for biofabrication are often referred to as bioinks and have become an important area of research within the field. In view of this special issue on bioinks, we aim herein to briefly summarize the historic evolution of this term within the field of biofabrication. Furthermore, we propose a simple but general definition of bioinks, and clarify its distinction from biomaterial inks.

Published
2018

23. Human BAC Clones: From Chromosomes To Sequences

Author

Cheung, V.G., Narasimhan, S., Arcaro, M., Weber, T., Burdick, J., Morley, M., and Bruzel, A.

Subjects
Genetic research -- Analysis, Human genetics -- Research, Biological sciences
Published
2000

24. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy : not all AIDS-defining conditions are created equal

Author

Antiretroviral Therapy Cohort Collaboration Mocroft A, Sterne JA, Egger M, May M, Grabar S, Furrer H, Sabin C, Fatkenheuer G, Justice A, Reiss P, d'Arminio Monforte A, Gill J, Hogg R, Bonnet F, Kitahata M, Staszewski S, Casabona J, Harris R, Saag M, Chêne G, Costagliola D, Dabis F, D'Arminio Monforte A, de Wolf F, Ledergerber B, Mocroft A, Phillips A, Weller I, Sterne J, Abgrall S, Barin F, Bentata M, Billaud E, Boué F, Burty C, Cabié A, Cotte L, De Truchis P, Duval X, Duvivier C, Enel P, Fredouille Heripret L, Gasnault J, Gaud C, Gilquin J, Katlama C, Khuong MA, Lang JM, Lascaux AS, Launay O, Mahamat A, Mary Krause M, Matheron S, Meynard JL, Pavie J, Pialoux G, Pilorgé F, Poizot Martin I, Pradier C, Reynes J, Rouveix E, Simon A, Tattevin P, Tissot Dupont H, Viard JP, Viget N, Pariente Khayat A, Salomon V, Jacquemet N, Rivet A, Guiguet M, Kousignian I, Lanoy E, Lièvre L, Potard V, Selinger Leneman H, Bouvet E, Crickx B, Ecobichon JL, Leport C, Picard Dahan C, Yeni P, Tisne Dessus D, Weiss L, Salmon D, Sicard D, Auperin I, Roudière L, Fior R, Delfraissy JF, Goujard C, Jung C, Lesprit P, Desplanque N, Meyohas MC, Picard O, Cadranel J, Mayaud C, Bricaire F, Herson S, Clauvel JP, Decazes JM, Gerard L, Molina JM, Diemer M, Sellier P, Berthé H, Dupont C, Chandemerle C, Mortier E, Honoré P, Jeantils V, Tassi S, Mechali D, Taverne B, Gourdon F, Laurichesse H, Fresard A, Lucht F, Eglinger P, Faller JP, Bazin C, Verdon R, Boibieux A, Peyramond D, Livrozet JM, Touraine JL, Trepo C, Ravaux I, Delmont JP, Moreau J, Gastaut JA, Retornaz F, Soubeyrand J, Allegre T, Blanc PA, Galinier A, Ruiz JM, Lepeu G, Granet Brunello P, Esterni JP, Pelissier L, Cohen Valensi R, Nezri M, Chadapaud S, Laffeuillade A, May T, Rabaud C, Raffi F, Arvieux C, Michelet C, Borsa Lebas F, Caron F, Fraisse P, Rey D, Arlet Suau E, Cuzin L, Massip P, Thiercelin Legrand MF, Yasdanpanah Y, Pradinaud R, Sobesky M, Contant M, Montroni M, Scalise G, Braschi MC, Riva A, Tirelli U, Martellotta F, Pastore G, Ladisa N, Suter F, Arici C, Chiodo F, Colangeli V, Fiorini C, Carosi G, Cristini G, Torti C, Minardi C, Bertelli D, Quirino T, Manconi PE, Piano P, Cosco L, Scerbo A, Vecchiet J, D'Alessandro M, Santoro D, Pusterla L, Carnevale G, Lorenzotti S, Viganò P, Mena M, Ghinelli F, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Lo Caputo S, Grisorio B, Ferrara S, Grima P, Grima PF, Pagano G, Cassola G, Alessandrini A, Piscopo R, Toti M, Trezzi M, Soscia F, Tacconi L, Orani A, Perini P, Scasso A, Vincenti A, Chiodera F, Castelli P, Scalzini A, Palvarini L, Moroni M, Lazzarin A, Rizzardini G, Caggese L, Cicconi P, Galli A, Merli S, Pastecchia C, Moioli MC, Esposito R, Mussini C, Abrescia N, Chirianni A, Izzo CM, Piazza M, De Marco M, Viglietti R, Manzillo E, Colomba A, Abbadessa V, Prestileo T, Mancuso S, Ferrari C, Pizzaferri P, Filice G, Minoli L, Bruno R, Novati S, Baldelli F, Camanni G, Petrelli E, Cioppi A, Alberici F, Ruggieri A, Menichetti F, Martinelli C, De Stefano C, La Gala A, Ballardini G, Rizzo E, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Dianzani F, Ippolito G, Antinori A, Antonucci G, Ciardi M, Narciso P, Petrosillo N, Vullo V, De Luca A, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Noto P, Lichtner M, Capobianchi MR, Carletti F, Girardi E, Pezzotti P, Rezza G, Mura MS, Mannazzu M, Caramello P, Di Perri G, Orofino GC, Sciandra M, Grossi PA, Basilico C, Poggio A, Bottari G, Raise E, Ebo F, Pellizzer G, Buonfrate D, Resta F, Loso K, Cozzi Lepri A, Battegay M, Bernasconi E, Böni J, Bucher H, Bürgisser P, Cattacin S, Cavassini M, Dubs R, Elzi L, Erb P, Fischer M, Flepp M, Fontana A, Francioli P, Gorgievski M, Günthard H, Hirsch H, Hirschel B, Hösli I, Kahlert C, Kaiser L, Karrer U, Kind C, Klimkait T, Martinetti G, Martinez B, Müller N, Nadal D, Opravil M, Paccaud F, Pantaleo G, Rickenbach M, Rudin C, Schmid P, Schultze D, Schüpbach J, Speck R, Taffé P, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Gras LA, van Sighem AI, Smit C, Bronsveld W, Hillebrand Haverkort ME, Prins JM, Branger J, Eeftinck Schattenkerk JK, Gisolf J, Godfried MH, Lange JM, Lettinga KD, van der Meer JT, Nellen FJ, van der Poll T, Ruys TA, Steingrover R, Vermeulen JN, Vrouenraets SM, van Vugt M, Wit FW, Kuijpers TW, Pajkrt D, Scherpbier HJ, van Eeden A, Brinkman K, van den Berk GE, Blok WL, Frissen PH, Roos JC, Schouten WE, Mulder JW, van Gorp EC, Wagenaar J, Veenstra J, Danner SA, Van Agtmael MA, Claessen FA, Perenboom RM, Rijkeboer A, van Vonderen MG, Richter C, van der Berg J, Vriesendorp R, Jeurissen FJ, Kauffmann RH, Pogány K, Bravenboer B, ten Napel CH, Kootstra GJ, Sprenger HG, van Assen S, van Leeuwen JT, Doedens R, Scholvinck EH, ten Kate RW, Soetekouw R, van Houte D, Polée MB, Kroon FP, van den Broek PJ, van Dissel JT, Schippers EF, Schreij G, van der Geest S, Lowe S, Verbon A, Koopmans PP, Van Crevel R, de Groot R, Keuter M, Post F, van der Ven AJ, Warris A, van der Ende ME, Gyssens IC, van der Feltz M, Nouwen JL, Rijnders BJ, de Vries TE, Driessen G, van der Flier M, Hartwig NG, Juttman JR, van Kasteren ME, Van de Heul C, Hoepelman IM, Schneider MM, Bonten MJ, Borleffs JC, Ellerbroek PM, Jaspers CA, Mudrikove T, Schurink CA, Gisolf EH, Geelen SP, Wolfs TF, Faber T, Tanis AA, Groeneveld PH, den Hollander JG, Duits AJ, Winkel K, Back NK, Bakker ME, Berkhout B, Jurriaans S, Zaaijer HL, Cuijpers T, Rietra PJ, Roozendaal KJ, Pauw W, van Zanten AP, Smits PH, von Blomberg BM, Savelkoul P, Pettersson A, Swanink CM, Franck PF, Lampe AS, Jansen CL, Hendriks R, Benne CA, Veenendaal D, Storm H, Weel J, van Zeijl JH, Kroes AC, Claas HC, Bruggeman CA, Goossens VJ, Galama JM, Melchers WJ, Poort YA, Doornum GJ, Niesters MG, Osterhaus AD, Schutten M, Buiting AG, Swaans CA, Boucher CA, Schuurman R, Boel E, Jansz AF, Veldkamp A, Beijnen JH, Huitema AD, Burger DM, Hugen PW, van Kan HJ, Losso M, Duran A, Vetter N, Karpov I, Vassilenko A, Mitsura VM, Suetnov O, Clumeck N, De Wit S, Poll B, Colebunders R, Kostov K, Begovac J, Machala L, Rozsypal H, Sedlacek D, Nielsen J, Lundgren J, Benfield T, Kirk O, Gerstoft J, Katzenstein T, Hansen AB, Skinhøj P, Pedersen C, Oestergaard L, Zilmer K, Ristola M, Girard PM, Vanhems P, Rockstroh J, Schmidt R, van Lunzen J, Degen O, Stellbrink HJ, Bogner J, Kosmidis J, Gargalianos P, Xylomenos G, Perdios J, Panos G, Filandras A, Karabatsaki E, Sambattakou H, Banhegyi D, Mulcahy F, Yust I, Turner D, Burke M, Pollack S, Hassoun G, Maayan S, Chiesi A, Mazeu I, Pristera R, Gabbuti A, Montesarchio E, Gargiulo M, Iacomi F, Vlassi C, Finazzi R, Galli M, Ridolfo A, Rozentale B, Aldins P, Chaplinskas S, Hemmer R, Staub T, Bruun J, Maeland A, Ormaasen V, Knysz B, Gasiorowski J, Horban A, Prokopowicz D, Wiercinska Drapalo A, Boron Kaczmarska A, Pynka M, Beniowski M, Mularska E, Trocha H, Antunes F, Valadas E, Mansinho K, Maltez F, Duiculescu D, Rakhmanova A, Vinogradova E, Buzunova S, Jevtovic D, Mokrás M, Staneková D, González Lahoz J, Soriano V, Martin Carbonero L, Labarga P, Clotet B, Jou A, Conejero J, Tural C, Gatell JM, Miró JM, Domingo P, Gutierrez M, Mateo G, Sambeat MA, Karlsson A, Persson PO, Flamholc L, Boffi E, Kravchenko E, Chentsova N, Barton S, Johnson AM, Mercey D, Johnson MA, Murphy M, Weber J, Scullard G, Fisher M, Brettle R, Gatell J, Gazzard B, Friis Møller N, Bannister W, Ellefson M, Borch A, Podlekareva D, Holkmann Olsen C, Kjaer J, Peters L, Reekie J, Raffanti S, Dieterch D, Becker S, Scarsella A, Fusco G, Most B, Balu R, Rana R, Beckerman R, Ising T, Fusco J, Irek R, Johnson B, Hirani A, DeJesus E, Pierone G, Lackey P, Irek C, Johnson A, Burdick J, Leon S, Arch J, Helm EB, Carlebach A, Müller A, Haberl A, Nisius G, Lennemann T, Stephan C, Bickel M, Mösch M, Gute P, Locher L, Lutz T, Klauke S, Knecht G, Khaykin P, Doerr HW, Stürmer M, Babacan E, von Hentig N, Beylot J, Dupon M, Longy Boursier M, Pellegrin JL, Ragnaud JM, Salamon R, Thiébaut R, Lewden C, Lawson Ayayi S, Mercié P, Moreau JF, Morlat P, Bernard N, Lacoste D, Malvy D, Neau D, Blaizeau MJ, Decoin M, Delveaux S, Hannapier C, Labarrère S, Lavignolle Aurillac V, Uwamaliya Nziyumvira B, Palmer G, Touchard D, Balestre E, Alioum A, Jacqmin Gadda H, Bonarek M, Coadou B, Gellie P, Nouts C, Bocquentin F, Dutronc H, Lafarie S, Aslan A, Pistonne T, Thibaut P, Vatan R, Chambon D, De La Taille C, Cazorla C, Ocho A, Viallard JF, Caubet O, Cipriano C, Lazaro E, Couzigou P, Castera L, Fleury H, Lafon ME, Masquelier B, Pellegrin I, Breilh D, Blanco P, Loste P, Caunègre L, Bonnal F, Farbos S, Ferrand M, Ceccaldi J, Tchamgoué S, De Witte S, Buy E, Alexander C, Barrios R, Braitstein P, Brumme Z, Chan K, Cote H, Gataric N, Geller J, Guillemi S, Harrigan PR, Harris M, Joy R, Levy A, Montaner J, Montessori V, Palepu A, Phillips E, Phillips P, Press N, Tyndall M, Wood E, Yip B, Bhagani S, Breen R, Byrne P, Carroll A, Cuthbertson Z, Dunleavy A, Geretti AM, Heelan B, Johnson M, Kinloch de Loes S, Lipman M, Madge S, Marshall N, Nair D, Nebbia G, Prinz B, Shah S, Swader L, Tyrer M, Youle M, Chaloner C, Grabowska H, Holloway J, Puradiredja J, Ransom D, Tsintas R, Bansi L, Fox Z, Harris E, Hill T, Lampe F, Lodwick R, Smith C, Amoah E, Booth C, Clewley G, Garcia Diaz A, Gregory B, Janossy G, Labbett W, Thomas M, Read R, Krentz H, Beckthold B, Schmeisser N, Alquézar A, Esteve A, Podzamczer D, Murillas J, Romero A, Agustí C, Agüero F, Ferrer E, Riera M, Segura F, Navarro G, Force L, Vilaró J, Masabeu A, García I, Guadarrama M, Montoliu A, Ortega N, Lazzari E, Puchol E, Sanchez M, Blanco JL, Garcia Alcaide F, Martinez E, Mallolas J, López Dieguez M, García Goez JF, Sirera G, Romeu J, Negredo E, Miranda C, Capitan MC, Olmo M, Barragan P, Saumoy M, Bolao F, Cabellos C, Peña C, Sala M, Cervantes M, Jose Amengual M, Navarro M, Penelo E, Barrufet P, Raper JL, Mugavero MJ, Willig JH, Schumacher J, Chang PW, Westfall AO, Cloud G, Lin HY, Acosta EP, Colette Kempf M, Allison JJ, Pisu M., NAPPA, SALVATORE, Mocroft, A, Mancuso, S, Antiretroviral Therapy Cohort Collaboration Mocroft, A, Sterne, Ja, Egger, M, May, M, Grabar, S, Furrer, H, Sabin, C, Fatkenheuer, G, Justice, A, Reiss, P, d'Arminio Monforte, A, Gill, J, Hogg, R, Bonnet, F, Kitahata, M, Staszewski, S, Casabona, J, Harris, R, Saag, M, Chêne, G, Costagliola, D, Dabis, F, D'Arminio Monforte, A, de Wolf, F, Ledergerber, B, Phillips, A, Weller, I, Sterne, J, Abgrall, S, Barin, F, Bentata, M, Billaud, E, Boué, F, Burty, C, Cabié, A, Cotte, L, De Truchis, P, Duval, X, Duvivier, C, Enel, P, Fredouille Heripret, L, Gasnault, J, Gaud, C, Gilquin, J, Katlama, C, Khuong, Ma, Lang, Jm, Lascaux, A, Launay, O, Mahamat, A, Mary Krause, M, Matheron, S, Meynard, Jl, Pavie, J, Pialoux, G, Pilorgé, F, Poizot Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Tattevin, P, Tissot Dupont, H, Viard, Jp, Viget, N, Pariente Khayat, A, Salomon, V, Jacquemet, N, Rivet, A, Guiguet, M, Kousignian, I, Lanoy, E, Lièvre, L, Potard, V, Selinger Leneman, H, Bouvet, E, Crickx, B, Ecobichon, Jl, Leport, C, Picard Dahan, C, Yeni, P, Tisne Dessus, D, Weiss, L, Salmon, D, Sicard, D, Auperin, I, Roudière, L, Fior, R, Delfraissy, Jf, Goujard, C, Jung, C, Lesprit, P, Desplanque, N, Meyohas, Mc, Picard, O, Cadranel, J, Mayaud, C, Bricaire, F, Herson, S, Clauvel, Jp, Decazes, Jm, Gerard, L, Molina, Jm, Diemer, M, Sellier, P, Berthé, H, Dupont, C, Chandemerle, C, Mortier, E, Honoré, P, Jeantils, V, Tassi, S, Mechali, D, Taverne, B, Gourdon, F, Laurichesse, H, Fresard, A, Lucht, F, Eglinger, P, Faller, Jp, Bazin, C, Verdon, R, Boibieux, A, Peyramond, D, Livrozet, Jm, Touraine, Jl, Trepo, C, Ravaux, I, Delmont, Jp, Moreau, J, Gastaut, Ja, Retornaz, F, Soubeyrand, J, Allegre, T, Blanc, Pa, Galinier, A, Ruiz, Jm, Lepeu, G, Granet Brunello, P, Esterni, Jp, Pelissier, L, Cohen Valensi, R, Nezri, M, Chadapaud, S, Laffeuillade, A, May, T, Rabaud, C, Raffi, F, Arvieux, C, Michelet, C, Borsa Lebas, F, Caron, F, Fraisse, P, Rey, D, Arlet Suau, E, Cuzin, L, Massip, P, Thiercelin Legrand, Mf, Yasdanpanah, Y, Pradinaud, R, Sobesky, M, Contant, M, Montroni, M, Scalise, G, Braschi, Mc, Riva, A, Tirelli, U, Martellotta, F, Pastore, G, Ladisa, N, Suter, F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Cosco, L, Scerbo, A, Vecchiet, J, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Lorenzotti, S, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Lo Caputo, S, Grisorio, B, Ferrara, S, Grima, P, Grima, Pf, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Toti, M, Trezzi, M, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Palvarini, L, Moroni, M, Lazzarin, A, Rizzardini, G, Caggese, L, Cicconi, P, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Mussini, C, Abrescia, N, Chirianni, A, Izzo, Cm, Piazza, M, De Marco, M, Viglietti, R, Manzillo, E, Nappa, Salvatore, Colomba, A, Abbadessa, V, Prestileo, T, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Baldelli, F, Camanni, G, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, La Gala, A, Ballardini, G, Rizzo, E, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Cauda, R, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, Ciardi, M, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Noto, P, Lichtner, M, Capobianchi, Mr, Carletti, F, Girardi, E, Pezzotti, P, Rezza, G, Mura, M, Mannazzu, M, Caramello, P, Di Perri, G, Orofino, Gc, Sciandra, M, Grossi, Pa, Basilico, C, Poggio, A, Bottari, G, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Resta, F, Loso, K, Cozzi Lepri, A, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Gorgievski, M, Günthard, H, Hirsch, H, Hirschel, B, Hösli, I, Kahlert, C, Kaiser, L, Karrer, U, Kind, C, Klimkait, T, Martinetti, G, Martinez, B, Müller, N, Nadal, D, Opravil, M, Paccaud, F, Pantaleo, G, Rickenbach, M, Rudin, C, Schmid, P, Schultze, D, Schüpbach, J, Speck, R, Taffé, P, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R, Yerly, S, Gras, La, van Sighem, Ai, Smit, C, Bronsveld, W, Hillebrand Haverkort, Me, Prins, Jm, Branger, J, Eeftinck Schattenkerk, Jk, Gisolf, J, Godfried, Mh, Lange, Jm, Lettinga, Kd, van der Meer, Jt, Nellen, Fj, van der Poll, T, Ruys, Ta, Steingrover, R, Vermeulen, Jn, Vrouenraets, Sm, van Vugt, M, Wit, Fw, Kuijpers, Tw, Pajkrt, D, Scherpbier, Hj, van Eeden, A, Brinkman, K, van den Berk, Ge, Blok, Wl, Frissen, Ph, Roos, Jc, Schouten, We, Mulder, Jw, van Gorp, Ec, Wagenaar, J, Veenstra, J, Danner, Sa, Van Agtmael, Ma, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, Mg, Richter, C, van der Berg, J, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Pogány, K, Bravenboer, B, ten Napel, Ch, Kootstra, Gj, Sprenger, Hg, van Assen, S, van Leeuwen, Jt, Doedens, R, Scholvinck, Eh, ten Kate, Rw, Soetekouw, R, van Houte, D, Polée, Mb, Kroon, Fp, van den Broek, Pj, van Dissel, Jt, Schippers, Ef, Schreij, G, van der Geest, S, Lowe, S, Verbon, A, Koopmans, Pp, Van Crevel, R, de Groot, R, Keuter, M, Post, F, van der Ven, Aj, Warris, A, van der Ende, Me, Gyssens, Ic, van der Feltz, M, Nouwen, Jl, Rijnders, Bj, de Vries, Te, Driessen, G, van der Flier, M, Hartwig, Ng, Juttman, Jr, van Kasteren, Me, Van de Heul, C, Hoepelman, Im, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Jaspers, Ca, Mudrikove, T, Schurink, Ca, Gisolf, Eh, Geelen, Sp, Wolfs, Tf, Faber, T, Tanis, Aa, Groeneveld, Ph, den Hollander, Jg, Duits, Aj, Winkel, K, Back, Nk, Bakker, Me, Berkhout, B, Jurriaans, S, Zaaijer, Hl, Cuijpers, T, Rietra, Pj, Roozendaal, Kj, Pauw, W, van Zanten, Ap, Smits, Ph, von Blomberg, Bm, Savelkoul, P, Pettersson, A, Swanink, Cm, Franck, Pf, Lampe, A, Jansen, Cl, Hendriks, R, Benne, Ca, Veenendaal, D, Storm, H, Weel, J, van Zeijl, Jh, Kroes, Ac, Claas, Hc, Bruggeman, Ca, Goossens, Vj, Galama, Jm, Melchers, Wj, Poort, Ya, Doornum, Gj, Niesters, Mg, Osterhaus, Ad, Schutten, M, Buiting, Ag, Swaans, Ca, Boucher, Ca, Schuurman, R, Boel, E, Jansz, Af, Veldkamp, A, Beijnen, Jh, Huitema, Ad, Burger, Dm, Hugen, Pw, van Kan, Hj, Losso, M, Duran, A, Vetter, N, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, Clumeck, N, De Wit, S, Poll, B, Colebunders, R, Kostov, K, Begovac, J, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Lundgren, J, Benfield, T, Kirk, O, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Oestergaard, L, Zilmer, K, Ristola, M, Girard, Pm, Vanhems, P, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Bogner, J, Kosmidis, J, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambattakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Chiesi, A, Mazeu, I, Pristera, R, Gabbuti, A, Montesarchio, E, Gargiulo, M, Iacomi, F, Vlassi, C, Finazzi, R, Galli, M, Ridolfo, A, Rozentale, B, Aldins, P, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska Drapalo, A, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, F, Valadas, E, Mansinho, K, Maltez, F, Duiculescu, D, Rakhmanova, A, Vinogradova, E, Buzunova, S, Jevtovic, D, Mokrás, M, Staneková, D, González Lahoz, J, Soriano, V, Martin Carbonero, L, Labarga, P, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, Jm, Miró, Jm, Domingo, P, Gutierrez, M, Mateo, G, Sambeat, Ma, Karlsson, A, Persson, Po, Flamholc, L, Boffi, E, Kravchenko, E, Chentsova, N, Barton, S, Johnson, Am, Mercey, D, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Brettle, R, Gatell, J, Gazzard, B, Friis Møller, N, Bannister, W, Ellefson, M, Borch, A, Podlekareva, D, Holkmann Olsen, C, Kjaer, J, Peters, L, Reekie, J, Raffanti, S, Dieterch, D, Becker, S, Scarsella, A, Fusco, G, Most, B, Balu, R, Rana, R, Beckerman, R, Ising, T, Fusco, J, Irek, R, Johnson, B, Hirani, A, Dejesus, E, Pierone, G, Lackey, P, Irek, C, Johnson, A, Burdick, J, Leon, S, Arch, J, Helm, Eb, Carlebach, A, Müller, A, Haberl, A, Nisius, G, Lennemann, T, Stephan, C, Bickel, M, Mösch, M, Gute, P, Locher, L, Lutz, T, Klauke, S, Knecht, G, Khaykin, P, Doerr, Hw, Stürmer, M, Babacan, E, von Hentig, N, Beylot, J, Dupon, M, Longy Boursier, M, Pellegrin, Jl, Ragnaud, Jm, Salamon, R, Thiébaut, R, Lewden, C, Lawson Ayayi, S, Mercié, P, Moreau, Jf, Morlat, P, Bernard, N, Lacoste, D, Malvy, D, Neau, D, Blaizeau, Mj, Decoin, M, Delveaux, S, Hannapier, C, Labarrère, S, Lavignolle Aurillac, V, Uwamaliya Nziyumvira, B, Palmer, G, Touchard, D, Balestre, E, Alioum, A, Jacqmin Gadda, H, Bonarek, M, Coadou, B, Gellie, P, Nouts, C, Bocquentin, F, Dutronc, H, Lafarie, S, Aslan, A, Pistonne, T, Thibaut, P, Vatan, R, Chambon, D, De La Taille, C, Cazorla, C, Ocho, A, Viallard, Jf, Caubet, O, Cipriano, C, Lazaro, E, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Breilh, D, Blanco, P, Loste, P, Caunègre, L, Bonnal, F, Farbos, S, Ferrand, M, Ceccaldi, J, Tchamgoué, S, De Witte, S, Buy, E, Alexander, C, Barrios, R, Braitstein, P, Brumme, Z, Chan, K, Cote, H, Gataric, N, Geller, J, Guillemi, S, Harrigan, Pr, Harris, M, Joy, R, Levy, A, Montaner, J, Montessori, V, Palepu, A, Phillips, E, Phillips, P, Press, N, Tyndall, M, Wood, E, Yip, B, Bhagani, S, Breen, R, Byrne, P, Carroll, A, Cuthbertson, Z, Dunleavy, A, Geretti, Am, Heelan, B, Johnson, M, Kinloch de Loes, S, Lipman, M, Madge, S, Marshall, N, Nair, D, Nebbia, G, Prinz, B, Shah, S, Swader, L, Tyrer, M, Youle, M, Chaloner, C, Grabowska, H, Holloway, J, Puradiredja, J, Ransom, D, Tsintas, R, Bansi, L, Fox, Z, Harris, E, Hill, T, Lampe, F, Lodwick, R, Smith, C, Amoah, E, Booth, C, Clewley, G, Garcia Diaz, A, Gregory, B, Janossy, G, Labbett, W, Thomas, M, Read, R, Krentz, H, Beckthold, B, Schmeisser, N, Alquézar, A, Esteve, A, Podzamczer, D, Murillas, J, Romero, A, Agustí, C, Agüero, F, Ferrer, E, Riera, M, Segura, F, Navarro, G, Force, L, Vilaró, J, Masabeu, A, García, I, Guadarrama, M, Montoliu, A, Ortega, N, Lazzari, E, Puchol, E, Sanchez, M, Blanco, Jl, Garcia Alcaide, F, Martinez, E, Mallolas, J, López Dieguez, M, García Goez, Jf, Sirera, G, Romeu, J, Negredo, E, Miranda, C, Capitan, Mc, Olmo, M, Barragan, P, Saumoy, M, Bolao, F, Cabellos, C, Peña, C, Sala, M, Cervantes, M, Jose Amengual, M, Navarro, M, Penelo, E, Barrufet, P, Raper, Jl, Mugavero, Mj, Willig, Jh, Schumacher, J, Chang, Pw, Westfall, Ao, Cloud, G, Lin, Hy, Acosta, Ep, Colette Kempf, M, Allison, Jj, Pisu, M., Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, Other departments, General Internal Medicine, Graduate School, Global Health, Paediatric Infectious Diseases / Rheumatology / Immunology, and Medical Microbiology and Infection Prevention

Subjects
Male, Infectious diseases and international health [NCEBP 13], Lymphoma, 030312 virology, Esophageal candidiasis, Cohort Studies, 0302 clinical medicine, Interquartile range, 030212 general & internal medicine, AIDS-Related, Lymphoma, AIDS-Related, 0303 health sciences, Mortality rate, Progressive multifocal leukoencephalopathy, Hazard ratio, Prognosis, 3. Good health, Pathogenesis and modulation of inflammation [N4i 1], Infectious Diseases, Combination, Drug Therapy, Combination, Female, Infection and autoimmunity [NCMLS 1], Human, Microbiology (medical), Adult, medicine.medical_specialty, Prognosi, Anti-HIV Agents, antiretroviral therapy, Infectious Disease, Article, AIDS-Related Opportunistic Infection, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Drug Therapy, Internal medicine, medicine, Humans, AIDS-defining event, Proportional Hazards Models, AIDS-Related Opportunistic Infections/diagnosis/ mortality, Acquired Immunodeficiency Syndrome/complications/diagnosis/drug, therapy/ mortality, Anti-HIV Agents/ therapeutic use, AIDS-Related/diagnosis/mortality, Acquired Immunodeficiency Syndrome, AIDS-Related Opportunistic Infections, business.industry, Proportional hazards model, Poverty-related infectious diseases [N4i 3], Anti-HIV Agent, medicine.disease, mortality, Confidence interval, Immunology, Proportional Hazards Model, Cohort Studie, business
Abstract

Contains fulltext : 80963.pdf (Publisher’s version ) (Open Access) BACKGROUND: The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. METHODS: We analyzed data from 31,620 patients with no prior ADEs who started combination antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for sex, HIV transmission group, number of antiretroviral drugs initiated, regimen, age, date of starting combination antiretroviral therapy, and CD4+ cell count and HIV RNA load at initiation of combination antiretroviral therapy. ADEs that occurred in

Published
2009

25. A Robotically-Assembled 100-Meter Space Telescope

Author

Hogstrom, K., Backes, P., Burdick, J., Kennedy, B., Kim, J., Lee, N., Malakhova, G., Mukherjee, R., Sergio Pellegrino, and Wu, Y. -H

Abstract

The future of astronomy may rely on extremely large space telescopes in order to image Earth-sized exoplanets or study the first stars. These telescopes will not be possible without a radical shift in design methods and concepts that are not limited by the size of a single payload fairing. In-Space Telescope Assembly Robotics (ISTAR) is one solution. The ISTAR project has developed a concept for an optical space telescope with a collecting area of nearly 8000 square meters, launched in pieces from the ground, and assembled by highly dexterous robots in space. The concept has been demonstrated to meet optical requirements and failure criteria. This paper focuses on the design and feasibility analysis of the telescope structure, as it has to be stiff and precise enough to maintain optical tolerances while also being amenable to robotic operations. The overall optical scheme of the telescope is first presented, which includes four main elements: a spherical primary mirror roughly hexagonal in shape spanning 100 meters flat to flat; an eyepiece containing all subsequent mirrors and detectors; a metrology system; and a sun shade. The conceived structure that connects and supports these components is then detailed, beginning with the concept of operations and assembly process and ending with the results of a comprehensive structural analysis. Particular attention is given to the truss structure that supports the primary mirror segments, called the backplane. The backplane design uses both robotic assembly and deployable structures to reduce assembly time, featuring expanding truss modules grouped with pre-assembled clusters of mirror segments that are connected together in space. The truss geometry of the structure was chosen from a vast design space, which was first narrowed using “back-of-the-envelope” analytical methods, to satisfy vibrational stiffness and mass criteria. Higher fidelity simulations using finite element analysis and matrix methods were then used to demonstrate that the structure meets optical and failure strength requirements while subjected to loads typically encountered in the space environment. This paper includes many of the decisions and trades made throughout the activity, providing a reference for the design of large modular space structures and laying the groundwork for future flight missions of this nature.

Published
2014

27. Moderated Poster Session 4: Monday 4 May 2015, 15:30-16:30 * Room: Moderated Poster Area

Author

Werner, R. A., primary, Maya, Y., additional, Yamane, T., additional, Rischpler, C., additional, Fukushima, K., additional, Chen, X., additional, Lapa, C., additional, Herrmann, K., additional, Higuchi, T., additional, Thorn, S., additional, Stacy, M., additional, Purcell, B., additional, Doviak, H., additional, Shuman, J., additional, Perez, E., additional, Burdick, J., additional, Spinale, F., additional, Sinusas, A., additional, Treibel, T., additional, Bandula, S., additional, Fontana, M., additional, White, S., additional, Gilbertson, J., additional, Punwani, S., additional, Gillmore, J., additional, Hawkins, P., additional, Taylor, S., additional, Moon, J., additional, Caobelli, F., additional, Wollenweber, T., additional, Kuehn, C., additional, Bavendiek, U., additional, Schuetze, C., additional, Geworski, L., additional, Bauersachs, J., additional, Haverich, A., additional, Bengel, F., additional, Barysheva, N., additional, Merkulova, I., additional, Shabanova, M., additional, Gaman, S., additional, Veselova, T., additional, Shariya, M., additional, Kelion, A. D., additional, Pakkal, M., additional, Chowdhury, F., additional, Nagaraj, N., additional, Birchall, J., additional, Dixon, K., additional, Banya, W., additional, Mccann, G., additional, Gershlick, A., additional, Dirschinger, R., additional, Nicolosi, S., additional, Kossmann, H., additional, Meinicke, A., additional, Hanus, F., additional, Goetze, K., additional, Laugwitz, K., additional, Schwaiger, M., additional, and Nekolla, S., additional

Published
2015
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32. Eccentricity estimator for wide-angle fovea sensor by FMI descriptor approach

Author

Shimizu, Sota, Burdick, J. W., Shimizu, Sota, and Burdick, J. W.

Abstract

This paper proposes a method for estimating eccentricity that corresponds to an incident angle to a fovea sensor. The proposed method applies Fourier-Mellin Invariant descriptor for estimating rotation, scale, and translation, by taking both geometrical distortion and non-uniform resolution of a space-variant image by the fovea sensor into account. The following 2 points are focused in this paper. One is to use multi-resolution images computed by discrete wavelet transform for reducing noise caused by foveation properly. Another is to use a variable window function (although the window function is generally used for reducing DFT leakage caused by both ends of a signal.) for changing an effective field of view (FOV) in order not to sacrifice high accuracy. The simulation compares the root mean square (RMS) of the foveation noise between uniform and non-uniform resolutions, when a resolution level and a FOV level are changed, respectively. Experimental results show that the proposed method is consistent with the wide-angle space-variant image by the fovea sensor, i.e., it does not sacrifice high accuracy in the central FOV.

Published
2009

33. A General Stance Stability Test Based on Stratified Morse Theory With Application to Quasi-Static Locomotion Planning

Author

Rimon, E., Mason, R., Burdick, J. W., Or, Y., Rimon, E., Mason, R., Burdick, J. W., and Or, Y.

Abstract

This paper considers the stability of an object supported by several frictionless contacts in a potential field such as gravity. The bodies supporting the object induce a partition of the object's configuration space into strata corresponding to different contact arrangements. Stance stability becomes a geometric problem of determining whether the object's configuration is a local minimum of its potential energy function on the stratified configuration space. We use Stratified Morse Theory to develop a generic stance stability test that has the following characteristics. For a small number of contacts---less than three in 2-D and less than six in 3-D---stance stability depends both on surface normals and surface curvature at the contacts. Moreover, lower curvature at the contacts leads to better stability. For a larger number of contacts, stance stability depends only on surface normals at the contacts. The stance stability test is applied to quasi-static locomotion planning in two dimensions. The region of stable center-of-mass positions associated with a $k$-contact stance is characterized. Then, a quasi-static locomotion scheme for a three-legged robot over a piecewise linear terrain is described. Finally, friction is shown to provide robustness and enhanced stability for the frictionless locomotion plan. A full maneuver simulation illustrates the locomotion scheme.

Published
2008

34. Integrated parylene-cabled silicon probes for neural prosthetics

Author

Huang, R., Pang, C., Tai, Y. C., Emken, J., Ustun, C., Andersen, R., Burdick, J., Huang, R., Pang, C., Tai, Y. C., Emken, J., Ustun, C., Andersen, R., and Burdick, J.

Abstract

Recent advances in the field of neural prosthetics have demonstrated the thought control of a computer cursor. This capability relies primarily on electrode array surgically implanted into the brain as an acquisition source of neural activity. Various technologies have been developed for signal extraction; however most suffer from either fragile electrode shanks and bulky cables or inefficient use of surgical site areas. Here we present a design and initial testing results from high electrode density, silicon based arrays system with an integrated parylene cable. The greatly reduced flexible rigidity of the parylene cable is believed to relief possible mechanical damages due to relative motion between a brain and its skull.

Published
2008

35. A hybrid systems model for supervisory cognitive state identification and estimation in neural prosthetics

Author

Hudson, N., Burdick, J. W., Hudson, N., and Burdick, J. W.

Abstract

This paper presents a method to identify a class of hybrid system models that arise in cognitive neural prosthetic medical devices that aim to help the severely handicapped. In such systems a “supervisory decoder” is required to classify the activity of multi-unit extracellular neural recordings into a discrete set of modes that model the evolution of the brain’s planning process. We introduce a Gibbs sampling method to identify the key parameters of a GLHMM, a hybrid dynamical system that combines a set of generalized linear models (GLM) for dynamics of neuronal signals with a hidden Markov model (HMM) that describes the discrete transitions between the brain’s cognitive or planning states. Multiple neural signals of mixed type, including local field potentials and spike arrival times, are integrated into the model using the GLM framework. The identified model can then be used as the basis for the supervisory decoding (or estimation) of the current cognitive or planning state. The identification algorithm is applied to extracellular neural recordings obtained from set of electrodes acutely implanted in the posterior parietal cortex of a rhesus monkey. The results demonstrate the ability to accurately decode changes in behavioral or cognitive state during reaching tasks, even when the model parameters are identified from small data sets. The GLHMM models and the associated identification methods are generally applicable beyond the neural application domain.

Published
2008

36. High-Density Flexible Parylene-Based Multielectrode Arrays for Retinal and Spinal Cord Stimulation

Author

Rodger, D. C., Fong, A. J., Li, W., Ameri, H., Lavrov, I., Zhong, H., Saati, S., Menon, P., Meng, E., Burdick, J. W., Roy, R. R., Edgerton, V. R., Weiland, J. D., Humayun, M. S., Tai, Y. C., Rodger, D. C., Fong, A. J., Li, W., Ameri, H., Lavrov, I., Zhong, H., Saati, S., Menon, P., Meng, E., Burdick, J. W., Roy, R. R., Edgerton, V. R., Weiland, J. D., Humayun, M. S., and Tai, Y. C.

Abstract

Novel flexible parylene-based high-density electrode arrays have been developed for functional electrical stimulation in retinal and spinal cord applications. These electrode arrays are microfabricated according to single-metal-layer and, most recently, dual-metal-layer processes. A new heat-molding process has been implemented to conform electrode arrays to approximate the curvature of canine retinas, and chronic implantation studies have been undertaken to study the mechanical effects of parylene-based prostheses on the retina, with excellent results to date. Electrode arrays have also been implanted and tested on the spinal cords of murine models, with the ultimate goal of facilitation of locomotion after spinal cord injury; these arrays provide a higher density and better spatial control of stimulation and recording than is typically possible using traditional fine-wire electrodes. Spinal cord stimulation typically elicited three muscle responses, an early (direct), a middle (monosynaptic), and a late (polysynaptic) response, classified based on latency after stimulation. Stimulation at different rostrocaudal levels of the cord yielded markedly different muscle responses, highlighting the need for such high-density arrays.

Published
2007

37. Electrolysis-based diaphragm actuators

Author

Pang, C., Tai, Y.-C., Burdick, J. W., Andersen, R. A., Pang, C., Tai, Y.-C., Burdick, J. W., and Andersen, R. A.

Abstract

This work presents a new electrolysis-based microelectromechanical systems (MEMS) diaphragm actuator. Electrolysis is a technique for converting electrical energy to pneumatic energy. Theoretically electrolysis can achieve a strain of 136 000% and is capable of generating a pressure above 200 MPa. Electrolysis actuators require modest electrical power and produce minimal heat. Due to the large volume expansion obtained via electrolysis, small actuators can create a large force. Up to 100 µm of movement was achieved by a 3 mm diaphragm. The actuator operates at room temperature and has a latching and reversing capability.

Published
2006

38. Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice

Author

Cai, L. L., Fong, A. J., Otoshi, C. K., Liang, Y. Q., Cham, J. G., Zhong, H., Roy, R. R., Edgerton, V. R., Burdick, J. W., Cai, L. L., Fong, A. J., Otoshi, C. K., Liang, Y. Q., Cham, J. G., Zhong, H., Roy, R. R., Edgerton, V. R., and Burdick, J. W.

Abstract

This paper studies the possible benefit that can be obtained by introducing variability into the robotic control of trajectories used to train hindlimb locomotion in adult spinal mice. The spinal cords of adult female Swiss-Webster mice were completely transected at a mid-thoracic level. Fourteen days post-transection, the spinal mice were robotically trained to step in the presence of a 5-HT agonist, quipazine, for a period of six weeks. In this pilot study nine animals were divided into three groups, each receiving a different control strategy: a fixed training trajectory (Group A), a variable training trajectory without interlimb coordination imposed (Group B) and a variable training trajectory with hindlimb bilateral coordination imposed (Group C). Preliminary results indicate that Group A recovers more slowly than the two groups receiving variable modes of robotic training. Groups B and C show higher levels of recovery than Group A in terms of the number of steps performed during testing sessions, as well as in their step periodicity and shape consistency. Group C displays a higher incidence of alternating stepping than Group B. These results indicate that variable trajectory robotic training paradigms may be more effective than fixed trajectory paradigms in promoting robust post-injury stepping behavior. Furthermore, it appears that the inclusion of interlimb coordination is an important contribution to successful training.

Published
2005

39. Cognitive based neural prosthetics

Author

Andersen, R. A., Musallam, S., Burdick, J. W., Cham, J. G., Andersen, R. A., Musallam, S., Burdick, J. W., and Cham, J. G.

Abstract

Intense activity in neural prosthetic research has recently demonstrated the possibility of robotic interfaces that respond directly to the nervous system. The question remains of how the flow of information between the patient and the prosthetic device should be designed to provide a safe, effective system that maximizes the patient’s access to the outside world. Much recent work by other investigators has focused on using decoded neural signals as low-level commands to directly control the trajectory of screen cursors or robotic end-effectors. Here we review results that show that high-level, or cognitive, signals can be decoded from planned arm movements. These results, coupled with fundamental limitations in signal recording technology, motivate an approach in which cognitive neural signals play a larger role in the neural interface. This proposed paradigm predicates that neural signals should be used to instruct external devices, rather than control their detailed movement. This approach will reduce the effort required of the patient and will take advantage of established and on-going robotics research in intelligent systems and human-robot interfaces.

Published
2005

42. Recording advances for neural prosthetics

Author

Andersen, R. A., Burdick, J. W., Musallam, S., Scherberger, H., Pesaran, B., Meeker, D., Corneil, B. D., Fineman, I., Nenadic, Z., Branchaud, E., Cham, J. G., Greger, B., Tai, Y. C., Mojarradi, M. M., Andersen, R. A., Burdick, J. W., Musallam, S., Scherberger, H., Pesaran, B., Meeker, D., Corneil, B. D., Fineman, I., Nenadic, Z., Branchaud, E., Cham, J. G., Greger, B., Tai, Y. C., and Mojarradi, M. M.

Abstract

An important challenge for neural prosthetics research is to record from populations of neurons over long periods of time, ideally for the lifetime of the patient. Two new advances toward this goal are described, the use of local field potentials (LFPs) and autonomously positioned recording electrodes. LFPs are the composite extracellular potential field from several hundreds of neurons around the electrode tip. LFP recordings can be maintained for longer periods of time than single cell recordings. We find that similar information can be decoded from LFP and spike recordings, with better performance for state decodes with LFPs and, depending on the area, equivalent or slightly less than equivalent performance for signaling the direction of planned movements. Movable electrodes in microdrives can be adjusted in the tissue to optimize recordings, but their movements must be automated to be a practical benefit to patients. We have developed automation algorithms and a meso-scale autonomous electrode testbed, and demonstrated that this system can autonomously isolate and maintain the recorded signal quality of single cells in the cortex of awake, behaving monkeys. These two advances show promise for developing very long term recording for neural prosthetic applications.

Published
2004

44. A comparative study of probabilistic roadmap planners

Author

Geometrie, Beeldwetenschappen en Virtuele Omgevingen, Dep Informatica, Geraerts, R.J., Overmars, M.H., Boissonnat, J-D., Burdick, J., Goldberg, K., Hutchinson, S., Geometrie, Beeldwetenschappen en Virtuele Omgevingen, Dep Informatica, Geraerts, R.J., Overmars, M.H., Boissonnat, J-D., Burdick, J., Goldberg, K., and Hutchinson, S.

Published
2003

45. Kinematic reducibility of multiple model systems

Author

Murphey, T. D., Burdick, J. W., Murphey, T. D., and Burdick, J. W.

Abstract

This paper considers the relationship between second order multiple model systems and first order multiple model systems. Such a relationship is important to, among other things, studying path planning for mechanical control systems. This is largely due to the fact that the computational complexity of a path planning problem rapidly increases with the dimension of the state space, implying that being able to reduce a path planning problem from TQ to Q can be helpful. Not surprisingly, the necessary and sufficient condition for such a reduction is that each model constituting a multiple model control system be reducible. We present an extensive example in order to illustrate how these results can provide insight into the control of some specific physical systems.

Published
2003

46. Experiments in nonsmooth control of distributed manipulation

Author

Murphey, T. D., Burdick, J. W., Burgess, J., Homyk, A., Murphey, T. D., Burdick, J. W., Burgess, J., and Homyk, A.

Abstract

This paper describes an experimental modular distributed manipulation system upon which one can implement a variety of control schemes. We have shown elsewhere that when one includes the nonsmooth effects of friction into a model of distributed manipulation, nonsmooth feedback laws must generally be used to control distributed manipulators. We summarize results obtained with this experimental system that confirm the validity of control schemes proposed by the authors in recent papers. We describe the control algorithms in some detail and include specifics of the experimental set-up and experimental results.

Published
2003

47. Smooth feedback control algorithms for distributed manipulators

Author

Murphey, T. D., Burdick, J. W., Murphey, T. D., and Burdick, J. W.

Abstract

This paper introduces a smooth control algorithm for controlling fully actuated distributed manipulation systems that operate by frictional contact. The control law scales linearly with the number of actuators and is simple to implement. Moreover, we prove that control law has desirable robustness properties in the presence of the nonsmooth mechanics inherent in distributed manipulation systems that rely upon frictional contact. This algorithm has been implemented on an experimental distributed manipulation test-bed, whose structure is briefly reviewed. The experimental results confirm the validity and performance of the algorithm.

Published
2003

48. Uncertainty Management for Complex Systems

Author

CALIFORNIA INST OF TECH PASADENA CONTROL AND DYNAMICAL SYSTEMS, Doyle, John, Marsden, J., Ortiz, M., Schroder, P., Burdick, J., CALIFORNIA INST OF TECH PASADENA CONTROL AND DYNAMICAL SYSTEMS, Doyle, John, Marsden, J., Ortiz, M., Schroder, P., and Burdick, J.

Abstract

MURI researchers at Caltech have made dramatic progress in creating a fundamental theory of uncertainty management in complex, multiscale systems with a variety of applications from shear flow turbulence to networking protocols to global optimization. Military and commercial technological visions emphasize ubiquitous control, communications, and computing, with both biology and nanotechnology creating additional novel multi-scale challenges. A rigorous, practical, and unified theoretical framework will be essential for this vision, but until now it has proven stubbornly elusive. This research offers not only a theoretical research direction of unprecedented promise, but one that has already proven remarkably useful in a wide variety of practical applications. The results of this research will not only provide a rigorous basis for designing future networks of networks involving ubiquitous control, communications, and computing, but also will resolve many persistent mysteries at the foundation of physics. The major objective of this research is to develop an understanding of uncertainty management in complex systems. In addition to fundamental theory, the authors' objective is to provide tools for modeling, tractable simulation, and control of complex systems, with an emphasis on uncertainty and robustness. The increase in robustness, productivity, and throughput created by the enormous internal complexity of the power grid, the Internet, and other complex systems is accompanied by new hypersensitivities to perturbations the system was not designed to handle. This phenomenon is at the heart of power law statistics observed in failure events, with mostly small events but a "heavy tail" of large events. This "robust-yet-fragile" feature is characteristic of complex systems throughout engineering and biology. Appendixes discuss highly optimized transitions to turbulence and laminar-turbulent transition forced by free-stream turbulence. (95 refs.)

Published
2002

49. Global exponential stabilizability for distributed manipulation systems

Author

Murphey, T. D., Burdick, J. W., Murphey, T. D., and Burdick, J. W.

Abstract

Considers the global exponential stability of planar distributed manipulation control schemes. The programmable vector field approach is a commonly proposed method for distributed manipulation control. The authors (2001) showed that when one takes into account the discreteness of actuator arrays and the mechanics of actuator/object contact, the controls designed by the programmable vector field approach can be unstable at the desired equilibrium configuration. We show here how a discontinuous feedback law that locally stabilizes the manipulated object at the equilibrium can be combined with the programmable vector field approach to control the object's motions. We prove that the combined system is globally exponentially stabilizable even in the presence of changes in contact state. Simulations illustrate the results.

Published
2002

50. Nonsmooth controllability theory and an example

Author

Murphey, T. D., Burdick, J. W., Murphey, T. D., and Burdick, J. W.

Abstract

Extends results in local controllability analysis for multiple model driftless affine (MMDA) control systems. Such controllability results can be interpreted as non-smooth extensions of Chow's theorem, and use a set-valued Lie bracket. In particular, we formulate controllability in terms of generalized differential quotients. Additionally, we present an extensive example in order to illustrate how these results can provide insight into the control of some specific physical systems. Moreover, the paper indicates that a multiple model system consisting of individually controllable models is not necessarily controllable.

Published
2002

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