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163 results on '"Buller, Richard"'

1. A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

Author

Lazar, Vladimir, Rubin, Eitan, Depil, Stephane, Pawitan, Yudi, Martini, Jean-François, Gomez-Navarro, Jesus, Yver, Antoine, Kan, Zhengyin, Dry, Jonathan R, Kehren, Jeanne, Validire, Pierre, Rodon, Jordi, Vielh, Philippe, Ducreux, Michel, Galbraith, Susan, Lehnert, Manfred, Onn, Amir, Berger, Raanan, Pierotti, Marco A, Porgador, Angel, Pramesh, CS, Ye, Ding-wei, Carvalho, Andre L, Batist, Gerald, Le Chevalier, Thierry, Morice, Philippe, Besse, Benjamin, Vassal, Gilles, Mortlock, Andrew, Hansson, Johan, Berindan-Neagoe, Ioana, Dann, Robert, Haspel, Joel, Irimie, Alexandru, Laderman, Steve, Nechushtan, Hovav, Omari, Amal S Al, Haywood, Trent, Bresson, Catherine, Soo, Khee Chee, Osman, Iman, Mata, Hilario, Lee, Jack J, Jhaveri, Komal, Meurice, Guillaume, Palmer, Gary, Lacroix, Ludovic, Koscielny, Serge, Eterovic, Karina Agda, Blay, Jean-Yves, Buller, Richard, Eggermont, Alexander, Schilsky, Richard L, Mendelsohn, John, Soria, Jean-Charles, Rothenberg, Mace, Scoazec, Jean-Yves, Hong, Waun Ki, and Kurzrock, Razelle

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Biotechnology, Cancer, Lung Cancer, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Molecular Targeted Therapy, Precision Medicine, Transcriptome, Tri-therapy, NSCLC, targeted therapies, algorithm, pathway, tri-therapy, Oncology and carcinogenesis
Abstract

Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. Targeted monotherapies produce high regression rates, albeit for limited patient subgroups, who inevitably succumb. We present a novel strategy for identifying customized combinations of triplets of targeted agents, utilizing a simplified interventional mapping system (SIMS) that merges knowledge about existent drugs and their impact on the hallmarks of cancer. Based on interrogation of matched lung tumor and normal tissue using targeted genomic sequencing, copy number variation, transcriptomics, and miRNA expression, the activation status of 24 interventional nodes was elucidated. An algorithm was developed to create a scoring system that enables ranking of the activated interventional nodes for each patient. Based on the trends of co-activation at interventional points, combinations of drug triplets were defined in order to overcome resistance. This methodology will inform a prospective trial to be conducted by the WIN consortium, aiming to significantly impact survival in metastatic NSCLC and other malignancies.

Published
2015

2. Heartland Virus and Hemophagocytic Lymphohistiocytosis in Immunocompromised Patient, Missouri, USA

Author

Carlson, Abigail L., Pastula, Daniel M., Lambert, Amy J., Staples, J. Erin, Muehlenbachs, Atis, Turabelidze, George, Eby, Charles S., Keller, Jesse, Hess, Brian, Buller, Richard S., Storch, Gregory A., Byrnes, Kathleen, Dehner, Louis, Kirmani, Nigar, and Kuhlmann, F. Matthew

Subjects
Tick-borne diseases -- Development and progression -- Health aspects, Infection -- Development and progression -- Health aspects, Health
Abstract

Heartland virus (HRTV; genus Phlebovirus, family Phenuiviridae [previously Bunyaviridae]) is a suspected tickborne pathogen in the United States (1). The virus was initially identified in 2009, and 9 cases of [...]

Published
2018
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3. Investigation of helicopter loading spectra variations on fatigue crack growth in titanium and aluminium alloys

Author

Buller, Richard Gregory and Irving, Phil E.

Abstract

An investigation has been made into the effect of omitting small, vibratory load cycles from a helicopter load spectrum on the fatigue crack growth rates of high strength titanium (Ti-lOV 2Fe 3A1) and aluminium (7010 T73651) alloys. The investigation is made in the light of new requirements for the damage tolerance design of transport helicopter structures that have normally been designed to safe life criteria. The work aims to improve the damage tolerance design of helicopter structures by understanding the contribution of the vibratory load cycles to fatigue crack growth damage. The experimental work consisted of two parts that considered fatigue crack growth under simple overload type loading and complex fatigue load sequences using compact tension specimens. Simple overload and underload tests were run under near-threshold, plane strain crack growth rates typical of those experienced in helicopter components. These were supplemented by crack closure measurements made using a strain gauge adhered close to the crack tip. Fatigue crack growth rate retardation was observed after an overload and this was reduced if a tensile underload was subsequently applied. The experimental evidence suggested that observed crack growth transient behaviour could be explained by a residual stress field mechanism ahead of the crack tip with closure only serving in a secondary role to modify the applied external loading. A fatigue load sequence was developed for a helicopter rotorhead component and included representations of manoeuvre loads superimposed with the high mean stress, vibratory load cycles. A technique of progressively omitting small load cycles of increasing range from this sequence was used to determine the effect of these cycles on the fatigue crack growth. It was found that the these cycles of 16% range caused up to 80% of the total crack length damage and that the observed crack growth rate of the cycles was three times greater than that predicted by a conservative fatigue crack growth model. These are significant observations because vibratory cycles are usually considered to be non-damaging under a safe life design to which most current transport helicopters have been certified to. It was proposed that the accelerated growth rate of these cycles was caused by frequent underloads in the rotorhead loading sequence. A residual stress field model was invoked to explain this behaviour. The results are used to provide guidance for damage tolerant design of helicopter structures.

Published
1999

6. Predictive Accuracy and Densitometric Analysis of Point-of-Care Immunoassay for Adenoviral Conjunctivitis

Author

Johnson, Spencer D., primary, Harthan, Jennifer S., additional, Than, Tammy, additional, Migneco, Mary K., additional, Shorter, Ellen, additional, Whiteside, Meredith M., additional, Morettin, Christina E., additional, Olson, Christian K., additional, Rosemann, Crystal A., additional, Margolis, Mathew S., additional, Haertter, Leonard W., additional, Huecker, Julia B., additional, Rodic-Polic, Bojana, additional, Buller, Richard S., additional, Storch, Gregory A., additional, Gordon, Mae O., additional, and Hartwick, Andrew T. E., additional

Published
2021
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8. Genome sequence of enterovirus D68 from St. Louis, Missouri, USA

Author

Wylie, Kristine M., Wylie, Todd N., Orvedahl, Anthony, Buller, Richard S., Herter, Brandi N., Magrini, Vincent, Wilson, Richard K., and Storch, Gregory A.

Subjects
Nucleotide sequencing -- Methods, DNA sequencing -- Methods, Enteroviruses -- Genetic aspects, Health
Abstract

To the Editor: During the current (2014) enterovirus/ rhinovirus season in the United States, enterovirus D68 (EV-D68) is circulating at an unprecedented level. As of October 6, 2014, the Centers [...]

Published
2015

18. Clinical and epidemiologic characterization of WU polyomavirus infection, St. Louis, Missouri

Author

Le, Binh-Minh, Demertzis, Lee M., Wu, Guang, Tibbets, Robert J., Buller, Richard, Arens, Max Q., Gaynor, Anne M., Storch, Gregory A., and Wang, David

Subjects
Polyoma virus -- Identification and classification, Polyoma virus -- Health aspects, Respiratory tract infections -- Risk factors, Respiratory tract infections -- Diagnosis, Respiratory tract infections -- Research
Abstract

WU polyomavirus is a recently described polyomavirus found in patients with respiratory infections. Of 2,637 respiratory samples tested in St. Louis, Missouri, 2.7% were positive for WU polyomavirus by PCR, [...]

Published
2007

26. Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in Persons Coinfected with Human Immuno deficiency Virus

Author

Paddock, Christopher D., Folk, Scott M., Shore, G. Merrill, Machado, Linda J., Huycke, Mark M., Slater, Leonard N., Liddell, Allison M., Buller, Richard S., Storch, Gregory A., Monson, Thomas P., Rimland, David, Sumner, John W., Singleton, Joseph, Bloch, Karen C., Tang, Yi-Wei, Standaert, Steven M., and Childs, James E.

Subjects
Comorbidity -- Research, HIV patients -- Health aspects, Ehrlichiosis -- Development and progression, Opportunistic infections -- Development and progression, Health, Health care industry
Published
2001

31. National Working Group Meeting on ALK diagnostics in lung cancer

Author

Cooper, Wendy, Fox, Stephen, O'Toole, Sandra, Morey, Adrienne, Frances, Glenn, Pavlakis, Nick, O'Byrne, Ken, Dettrick, Andrew, Leong, Trishe, Rathi, Vivek, Spagnolo, Dominic, Hemmings, Chris, Singh, Mahendra, Moffat, David, Tsao, Ming-Sound, Wilner, Keith, Buller, Richard, Pitman Lowenthal, Susan, Arifeen, Shams, Binko, Justin, Alam, Mahmood, Cooper, Wendy, Fox, Stephen, O'Toole, Sandra, Morey, Adrienne, Frances, Glenn, Pavlakis, Nick, O'Byrne, Ken, Dettrick, Andrew, Leong, Trishe, Rathi, Vivek, Spagnolo, Dominic, Hemmings, Chris, Singh, Mahendra, Moffat, David, Tsao, Ming-Sound, Wilner, Keith, Buller, Richard, Pitman Lowenthal, Susan, Arifeen, Shams, Binko, Justin, and Alam, Mahmood

Abstract

The global landscape of molecular testing is rapidly changing, with the recent publication of the International Association for the Study of Lung Cancer (IASLC)/College of American Pathologists (CAP) guidelines and the ALK Atlas. The IASLC/CAP guidelines recommend that tumors from patients with non-small cell lung cancer (NSCLC) be tested for ALK rearrangements in addition to epidermal growth factor receptor (EGFR) mutations. The spur for this recommendation is the availability of novel therapies that target these rearrangements. This article is based on coverage of a Pfizer-sponsored National Working Group Meeting on ALK Diagnostics in Lung Cancer, held around the 15th World Lung Cancer Conference, in Sydney on October 31, 2013. It is based on the presentations given by the authors at the meeting and the discussion that ensued. The content for this article was discussed and agreed on by the authors.

Published
2014

33. Cyclosporin A Reverses Chemoresistance in Patients With Gynecologic Malignancies1

Author

Sood, Anil K, Sorosky, Joel I, Squatrito, Robert C, Skilling, Jeffrey S, Anderson, Barrie, and Buller, Richard E

Subjects
Ovarian Neoplasms, Time Factors, Brief Article, Genital Neoplasms, Female, Uterine Cervical Neoplasms, Middle Aged, Drug Resistance, Multiple, Treatment Outcome, Uterine Neoplasms, Cyclosporine, Disease Progression, Humans, Female, Choriocarcinoma, Immunosuppressive Agents
Abstract

Multidrug resistance is a major obstacle in successful systemic therapy of gynecologic malignancies. The objectives of this study are to evaluate the activity of cyclosporin A used to overcome drug resistance in a variety of gynecologic malignancies. Forty women (29 with ovarian cancer, 7 with uterine cancer, 3 with cervical cancer, and 1 with choriocarcinoma) were treated with cyclosporin A, 4 mg/kg intravenously, 6 hours before and 18 hours after the specific chemotherapeutic agent, to which the tumor had developed drug resistance. All patients had shown resistance to the chemotherapy agent used in combination with cyclosporin A. All patients had been heavily pretreated (mean, 2.8 previous chemotherapy regimens). Overall, among 38 available patients with gynecologic malignancies, a 29% objective response rate was observed. Twenty-six (65%) of all patients received three or more cycles of cyclosporin A. There was a 25% response rate for patients with ovarian cancer patients and 50% for those with uterine cancer. There were no responses among the three patients with cervical cancer, and the patient with choriocarcinoma had a complete response. All patients were evaluable for toxicity. Leukopenia and nausea were the most common toxic reactions, but in most cases they were transient, and only three patients required a treatment delay. The most common grade 3 or 4 toxicity was thrombocytopenia, which was observed in 22% of the patients. Cyclosporin A is well tolerated and has significant potential for reversal of chemoresistance in heavily pretreated patients with ovarian and uterine malignancies.

Published
1999

36. Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination

Author

DiFeo, Analisa, primary, Narla, Goutham, additional, Hirshfeld, Jennifer, additional, Camacho-Vanegas, Olga, additional, Narla, Jyothsna, additional, Rose, Stephen L., additional, Kalir, Tamara, additional, Yao, Shen, additional, Levine, Alice, additional, Birrer, Michael J., additional, Bonome, Tomas, additional, Friedman, Scott L., additional, Buller, Richard E., additional, and Martignetti, John A., additional

Published
2006
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45. Infections withEhrlichia chaffeensisandEhrlichia ewingiiin Persons Coinfected with Human Immunodeficiency Virus

Author

Paddock, Christopher D., primary, Folk, Scott M., additional, Shore, G. Merrill, additional, Machado, Linda J., additional, Huycke, Mark M., additional, Slater, Leonard N., additional, Liddell, Allison M., additional, Buller, Richard S., additional, Storch, Gregory A., additional, Monson, Thomas P., additional, Rimland, David, additional, Sumner, John W., additional, Singleton, Joseph, additional, Bloch, Karen C., additional, Tang, Yi‐Wei, additional, Standaert, Steven M., additional, and Childs, James E., additional

Published
2001
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46. Molecular Determinants of Ovarian Cancer Plasticity

Author

Sood, Anil K., primary, Seftor, Elisabeth A., additional, Fletcher, Mavis S., additional, Gardner, Lynn M.G., additional, Heidger, Paul M., additional, Buller, Richard E., additional, Seftor, Richard E.B., additional, and Hendrix, Mary J.C., additional

Published
2001
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50. An ovarian cancer tumor marker, CA 125, comes of age

Author

Buller, Richard E. and DiSaia, Philip J.

Subjects
Tumor markers -- Research -- Care and treatment -- Prognosis, Cancer -- Care and treatment, Ovarian cancer -- Prognosis -- Research -- Care and treatment, Health, Care and treatment, Research, Prognosis
Abstract

The Scientific Board of the California Medical Association presents the following inventory of items of progress in obstetrics and gynecology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, research workers, or scholars to stay abreast of these items of progress in obstetrics and gynecology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another The items of progress listed below were selected by the Advisory Panel to the Section on Obstetrics and Gynecology of the California Medical Association, and the summaries were prepared under its direction., AN ANTIGEN COMMON to fetal coelomic epithelium and its adult derivatives, CA 125, has received intensive research and now practical clinical scrutiny in the management of ovarian carcinomas of an [...]

Published
1990

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