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1. Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective.

Author

Zaidat, Osama, Ribo, Marc, Mattle, Heinrich, Saver, Jeffrey, Bozorgchami, Hormozd, Yoo, Albert, Ehm, Alexandra, Kottenmeier, Emilie, Cameron, Heather, Qadeer, Rana, and Andersson, Tommy

Subjects
economics, stroke, thrombectomy, Brain Ischemia, Humans, Ischemic Stroke, Retrospective Studies, Stents, Stroke, Thrombectomy, Treatment Outcome, United States
Abstract

BACKGROUND: First-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed. OBJECTIVE: To assess the economic impact of achieving complete or near complete reperfusion after the first pass. METHODS: Post hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c-3 was achieved, stratified into two groups: (1) mTICI 2c-3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK). RESULTS: Among patients who achieved mTICI 2c-3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0-2 80.46% vs 61.04%, p

Published
2021

2. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study.

Author

de Havenon, Adam, Narata, Ana, Amelot, Aymeric, Saver, Jeffrey, Bozorgchami, Hormozd, Mattle, Heinrich, Ribo, Marc, Andersson, Tommy, and Zaidat, Osama

Subjects
angiography, brain, stroke, thrombectomy, Brain Ischemia, Endovascular Procedures, Humans, Infarction, Middle Cerebral Artery, Middle Cerebral Artery, Stroke, Thrombectomy, Treatment Outcome
Abstract

BACKGROUND: The benefit of endovascular thrombectomy for acute ischemic stroke with M2 segment middle cerebral artery occlusion remains controversial, with uncertainty and paucity of data specific to this population. OBJECTIVE: To compare outcomes between M1 and M2 occlusions in the Analysis of Revascularization in Ischemic Stroke with EmboTrap (ARISE II) trial. METHODS: We performed a prespecified analysis of the ARISE II trial with the primary outcome of 90-day modified Rankin Scale score of 0-2, which we termed good outcome. Secondary outcomes included reperfusion rates and major adverse events. The primary predictor was M2 occlusion, which we compared with M1 occlusion. RESULTS: We included 183 patients, of whom 126 (69%) had M1 occlusion and 57 (31%) had M2 occlusion. There was no difference in the reperfusion rates or adverse events between M2 and M1 occlusions. The rate of good outcome was not different in M2 versus M1 occlusions (70.2% vs 69.7%, p=0.946). In a logistic regression model adjusted for age, sex, and baseline National Institutes of Health Stroke Scale score, M2 occlusions did not have a significantly different odds of good outcome compared with M1 occlusions (OR 0.94, 95% CI 0.47 to 1.88, p=0.87). CONCLUSION: In ARISE II, M2 occlusions achieved a 70.2% rate of good outcome at 90 days, which is above published rates for untreated M2 occlusions and superior to prior reports of M2 occlusions treated with endovascular thrombectomy. We also report similar rates of good outcome, successful reperfusion, death, and other adverse events when comparing the M1 and M2 occlusions.

Published
2021

3. New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke: Primary Results of the Multicenter TIGER Trial.

Author

Gupta, Rishi, Saver, Jeffrey L, Levy, Elad, Zaidat, Osama O, Yavagal, Dileep, Liebeskind, David S, Khaldi, Ahmad, Gross, Bradley, Lang, Michael, Narayanan, Sandra, Jankowitz, Brian, Snyder, Kenneth, Siddiqui, Adnan, Davies, Jason, Lin, Eugene, Hassan, Ameer, Hanel, Ricardo, Aghaebrahim, Amin, Kaushal, Ritesh, Malek, Ali, Mueller-Kronast, Nils, Starke, Robert, Bozorgchami, Hormozd, Nesbit, Gary, Horikawa, Masahiro, Priest, Ryan, Liu, Jesse, Budzik, Ronald F, Pema, Peter, Vora, Nirav, Taqi, M Asif, Samaniego, Edgar, Wang, Qingliang Tony, Nossek, Erez, Dabus, Guilherme, Linfante, Italo, Puri, Ajit, Abergel, Eitan, Starkman, Sidney, Tateshima, Satoshi, Jadhav, Ashutosh P, and TIGER Trial Investigators

Subjects
TIGER Trial Investigators, Humans, Thrombectomy, Aged, Middle Aged, Female, Male, Endovascular Procedures, Ischemic Stroke, goal, intracranial hemorrhage, laboratories, reperfusion, stent, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

[Figure: see text].

Published
2021

4. Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment and Worse Outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke)

Author

Froehler, Michael T, Saver, Jeffrey L, Zaidat, Osama O, Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P, Haussen, Diogo C, Hellinger, Frank R, Yavagal, Dileep R, Yao, Tom L, Liebeskind, David S, Jadhav, Ashutosh P, Gupta, Rishi, Hassan, Ameer E, Martin, Coleman O, Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G, Gandhi, Ravi H, Peterson, Eric C, Dashti, Shervin R, Given, Curtis A, Mehta, Brijesh P, Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H, Kvamme, Peter, Grobelny, Thomas J, Hussain, Muhammad S, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J, Ecker, Robert D, Schirmer, Clemens M, Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P, Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H, Dumont, Travis M, Alhajeri, Abdulnasser, Taqi, M Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S, Chitale, Rohan, Deshaies, Eric M, Robinson, David H, Kallmes, David F, Baxter, Blaise W, Jumaa, Mouhammad A, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D, Suzuki, Shuichi, Fessler, Richard D, Almandoz, Josser E Delgado, Martin, Jerry C, and Mueller-Kronast, Nils H

Subjects
Stroke, Clinical Research, Brain Disorders, Endovascular Procedures, Hospitals, Humans, Ischemia, Patient Transfer, Prospective Studies, Registries, Survival Analysis, Thrombectomy, Time Factors, Treatment Outcome, emergency medical services, endovascular treatment, ischemic stroke, stent retriever, systems of care, STRATIS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundEndovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.MethodsSTRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours. Patients underwent MT with or without intravenous tissue plasminogen activator and were admitted to endovascular-capable centers via either interhospital transfer or direct presentation. The primary clinical outcome was functional independence (modified Rankin Score 0-2) at 90 days. We assessed (1) real-world time metrics of stroke care delivery, (2) outcome differences between direct and transfer patients undergoing MT, and (3) the potential impact of local hospital bypass.ResultsA total of 984 patients were analyzed. Median onset-to-revascularization time was 202.0 minutes for direct versus 311.5 minutes for transfer patients (P

Published
2017

6. Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions: Analysis From the North American Solitaire Stent-Retriever Acute Stroke Registry

Author

Zaidi, Syed F., Castonguay, Alicia C., Jumaa, Mouhammad A., Malisch, Tim W., Linfante, Italo, Marden, Franklin A., Abraham, Michael G., Chebl, Alex Bou, Novakovic, Roberta, Taqi, M. Asif, Nogueira, Raul G., Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Dabus, Guilherme, Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Nguyen, Thanh N., Yoo, Albert J., Shaltoni, Hashem, Janardhan, Vallabh, Chen, Peng R., Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, Gupta, Rishi, and Zaidat, Osama O.

Published
2019
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7. Impact of Balloon Guide Catheter Use on Clinical and Angiographic Outcomes in the STRATIS Stroke Thrombectomy Registry

Author

Zaidat, Osama O., Mueller-Kronast, Nils H., Hassan, Ameer E., Haussen, Diogo C., Jadhav, Ashutosh P., Froehler, Michael T., Jahan, Reza, Ali Aziz-Sultan, Mohammad, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Gupta, Rishi, Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin, Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad Shazam, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Chebl, Alex Bou, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, Muhammad A., Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David, Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammed, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado-Almandoz, Josser, Martin, Jerry C., and Liebeskind, David S.

Published
2019
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8. Abstract Number ‐ 7: Final Angiographic, Clinical and Thrombus Composition Results of 1000 Patients in the EXCELLENT Registry

Author

Nogueira, Raul G, primary, Andersson, Tommy, additional, Yoo, Albert J, additional, Hanel, Ricardo A, additional, Zaidat, Osama O, additional, Hacke, Werner, additional, Jovin, Tudor, additional, Fiehler, Jens, additional, De Meyer, Simon F, additional, Brinjikji, Waleed, additional, Doyle, Karen, additional, Liebeskind, David S, additional, Haussen, Diogo, additional, Inoa, Violiza, additional, Humphries, William, additional, Woodward, Keith B, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Bozorgchami, Hormozd, additional, Levy, Elad I, additional, Boor, Stephan, additional, Cohen, Jose, additional, Dashti, Shervin R, additional, Taqi, Muhammad A, additional, Budzik, Ronald F, additional, Schirmer, Clemens M, additional, Hussain, Shazam, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Puri, Ajit S, additional, Chitale, Rohan V, additional, Brekenfeld, Caspar, additional, and Siddiqui, Adnan H, additional

Published
2023
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9. Abstract 28: First Pass Outcomes And Associated Clot Characteristics: Secondary Analysis Of The Excellent Registry

Author

Andersson, Tommy, primary, Nogueira, Raul G, additional, Yoo, Albert J, additional, Hanel, Ricardo, additional, Zaidat, Osama O, additional, Hacke, Werner, additional, Jovin, Tudor, additional, Fiehler, Jens, additional, De Meyer, Simon F, additional, Brinjikji, Waleed, additional, Doyle, Karen, additional, Liebeskind, David S, additional, Haussen, Diogo C, additional, Inoa, Violiza, additional, Humphries, William E, additional, Woodward, Keith B, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Bozorgchami, Hormozd, additional, Levy, Elad I, additional, Boor, Stephan, additional, Cohen, Jose, additional, Dashti, Shervin R, additional, Taqi, Muhammad A, additional, Budzik, Ronald F, additional, Schirmer, Clemens M, additional, Hussain, M. Shazam, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Puri, Ajit S, additional, Chitale, Rohan V, additional, Brekenfeld, Caspar, additional, and Siddiqui, Adnan H, additional

Published
2023
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10. Abstract 24: Primary Results Of The Preset For Occlusive Stroke Treatment (prost) Randomized Clinical Trial

Author

Nogueira, Raul G, primary, Hanel, Ricardo, additional, Klisch, Joachim, additional, Moehlenbruch, Markus, additional, Bozorgchami, Hormozd, additional, Samaniego, Edgar A, additional, Liebeskind, David S, additional, Lobsien, Donald, additional, Pielenz, Daniel, additional, Sauvageau, Eric, additional, Aghaebrahim, Amin N, additional, Clark, Wayne M, additional, Priest, Ryan, additional, Ortega-Gutierrez, Santiago, additional, Lopes, Demetrius, additional, Billingsley, Joshua, additional, Haussen, Diogo C, additional, Al-Bayati, Alhamza R, additional, Siddiqui, Adnan H, additional, Chen, Michael, additional, Schramm, Peter, additional, Narayanan, Sandra, additional, Roth, Christian, additional, Boeckh-Behrens, Tobias, additional, Hassan, Ameer E, additional, Fifi, Johanna T, additional, Budzik, Ronald, additional, Tarpley, Jason W, additional, Starke, Robert, additional, and Raz, Eytan, additional

Published
2023
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11. Primary Results of the Multicenter ARISE II Study (Analysis of Revascularization in Ischemic Stroke With EmboTrap)

Author

Zaidat, Osama O., Bozorgchami, Hormozd, Ribó, Marc, Saver, Jeffrey L., Mattle, Heinrich P., Chapot, René, Narata, Ana Paula, Francois, Olivier, Jadhav, Ashutosh P., Grossberg, Jonathan A., Riedel, Christian H., Tomasello, Alejandro, Clark, Wayne M., Nordmeyer, Hannes, Lin, Eugene, Nogueira, Raul G., Yoo, Albert J., Jovin, Tudor G., Siddiqui, Adnan H., Bernard, Thierry, Claffey, Mairsíl, Andersson, Tommy, Ribo, M., Hetts, S., Hacke, W., Mehta, Brijesh, Hacein-Bey, L., Kim, A., Abou-Chebl, A., Shabe, P., Hetts, S., Hacein-Bey, L., Kim, A., Abou-Chebl, A., Dix, J., Gurian, J., Zink, W.E., Dabus, G., O’Leary, N., Reilly, A., Lee, K., Foley, J., Dolan, M., Hartley, E., Clark, T., Nadeau, K., Shama, J., Hull, L., Brown, B., Priest, R., Nesbit, G., Horikawa, M., Hoak, D., Petersen, B., Beadell, Noah, Herrick, Kory, White, C., Stacey, M., Ford, S., Liu, J., Ribó, M., Sanjuan, E., Sanchis, M., Molina, C., Rodríguez-Luna, D., Boned Riera, S., Pagola, J., Rubiera, M., Juega, J., Rodríguez, N., Muller, N., Stauder, M., Stracke, P., Heddier, M., Charron, V., Decock, A., Herbreteau, D., Bibi, R., De Sloovere, A.S., Doutreloigne, I., Pieters, D., Dewaele, T., Bourgeois, P., Vanhee, F., Vanderdouckt, P., Vancaster, E., Baxendell, L., Gilchrist, V., Cannon, Y., Graves, C., Armbruster, K., Jovin, T., Jankowitz, B., Ducruet, A., Aghaebrahim, A., Kenmuir, C., Shoirah, H., Molyneaux, B., Tadi, P., Walker, G., Starr, M., Doppelheuer, S., Schindler, K., Craft, L., Schultz, M., Perez, H., Park, J., Hall, A., Mitchell, A., Webb, L., Haussen, D., Frankel, M., Bianchi, N., Belagaje, S., Mahdi, N., Lahoti, S., Katema, A., Winningham, M., Anderson, A., Tilley, D.A., Steinhauser, T., Scott, D., Thacker, A., Calderon, V., Lin, E., Becke, S., Krieter, S., Jansen, O., Wodarg, F., Larsen, N., Binder, A., Wiesen, C., Hartney, M., Bookhagan, L., Ross, H., Gay, J., Snyder, K., Levy, E., Davies, J., Sonig, A., Rangel-Castilla, L., Mowla, A., Shakir, H., Fennell, V., Atwal, G., Natarajan, S., Beecher, J., Thornton, J., Cullen, A., Brennan, P., O’Hare, A., Asadi, H., Budzik, R., Taylor, M., Jennings, M., Laube, F., Jackson, J., Gatrell, R., Reebel, L., Albon, A., Gerniak, J., Groezinger, K., Lauf, M., Voraco, N., Pema, P., Davis, T., Hicks, W., Mejilla, J., Teleb, M., Sunenshine, P., Russo, E., Flynn, R., Twyford, J., Ver Hage, A., Smith, E., Apolinar, L., Blythe, S., Maxan, J., Carter, J., Taschner, T., Bergmann, U., Meckel, S., Elsheik, S., Urbach, H., Maurer, C., Egger, K., Niesen, W.D., Baxter, B.W., Knox, A., Hazelwood, B., Quarfordt, S., Calvert, J., Hawk, H., Malek, R., Padidar, A., Tolley, U., Gutierrez, A., Mordasini, P., Seip, T., Balasubramaniam, R., Gralla, J., Fischer, U., Zibold, F., Piechowiak, E., DeLeacy, R., Apruzzeses, R., Alfonso, C., Haslett, J., Fifi, J., Mocco, J., Starkman, S., Guzy, J., Grunberg, N., Szeder, V., Tateshima, S., Duckwiler, G., Nour, M., Liebeskind, D., Tang, X., Hinman, J., Tipirneni, A., Yavagal, D., Guada, L., Bates, K., Balladeras, S., Bokka, S.K., Suir, S., Caplan, J., Kandewall, P., Peterson, E., Starke, R.M., Puri, A., Hawk, M., Brooks, C., L’Heurex, J., Ty, K., Rex, D., Massari, F., Wakhloo, A., Lozano, D., Rodrigua, K.D., Pierot, L., Fabienne, M., Sebastien, S., and Emmoinoli, M.G.

Published
2018
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12. First Pass Effect: A New Measure for Stroke Thrombectomy Devices

Author

Zaidat, Osama O., Castonguay, Alicia C., Linfante, Italo, Gupta, Rishi, Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Dabus, Guilherme, Malisch, Tim W., Marden, Franklin A., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Nguyen, Thanh N., Taqi, M. Asif, Abraham, Michael G., Yoo, Albert J., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Roberta, Abou-Chebl, Alex, Chen, Peng R., Britz, Gavin W., Sun, Chung-Huan J., Bansal, Vibhav, Kaushal, Ritesh, Nanda, Ashish, and Nogueira, Raul G.

Published
2018
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13. Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry

Author

Mueller-Kronast, Nils H., Zaidat, Osama O., Froehler, Michael T., Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Liebeskind, David S., Jadhav, Ashutosh P., Gupta, Rishi, Hassan, Ameer E., Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin R., Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad S., Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, M. Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David H., Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammad A., Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado Almandoz, Josser E., Martin, Jerry C., and Haussen, Diogo C.

Published
2017
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14. Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry

Author

Linfante, Italo, Walker, Gail R., Castonguay, Alicia C., Dabus, Guilherme, Starosciak, Amy K., Yoo, Albert J., Abou-Chebl, Alex, Britz, Gavin W., Marden, Franklin A., Alvarez, Alexandria, Gupta, Rishi, Sun, Chun-Huan J., Martin, Coleman, Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Malisch, Tim W., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Nguyen, Thanh N., Taqi, M. Asif, Abraham, Michael G., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Roberta, Chen, Peng R., Kaushal, Ritesh, Nanda, Ashish, Issa, Mohammad A., Nogueira, Raul G., and Zaidat, Osama O.

Published
2015
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16. Influence of Age on Clinical and Revascularization Outcomes in the North American Solitaire Stent-Retriever Acute Stroke Registry

Author

Castonguay, Alicia C., Zaidat, Osama O., Novakovic, Roberta, Nguyen, Thanh N., Taqi, M. Asif, Gupta, Rishi, Sun, Chung-Huan J., Martin, Coleman, Holloway, William E., Mueller-Kronast, Nils, E. English, Joey, Linfante, Italo, Dabus, Guilherme, Malisch, Tim W., Marden, Franklin A., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Abraham, Michael G., Janardhan, Vallabh, Shaltoni, Hashem, Yoo, Albert J., Abou-Chebl, Alex, Chen, Peng R., Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, A. Issa, Mohammad, and Nogueira, Raul G.

Published
2014
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17. North American SOLITAIRE Stent-Retriever Acute Stroke Registry: Choice of Anesthesia and Outcomes

Author

Abou-Chebl, Alex, Zaidat, Ossama O., Castonguay, Alicia C., Gupta, Rishi, Sun, Chung-Huan J., Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Linfante, Italo, Dabus, Guilherme, Malisch, Timothy W., Marden, Franklin A., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Micahel T., Badruddin, Aamir, Nguyen, Thanh N., Taqi, Muhammad, Abraham, Michael G., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Roberta, Yoo, Albert J., Chen, Peng R., Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, Issa, Mohammad A., and Nogueira, Raul G.

Published
2014
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18. Predictors of unfavorable outcomes despite substantial reperfusion: Insights from Analysis of Revascularization in Ischemic Stroke With EmboTrap II Study.

Author

Siddiqui, Adnan H, Waqas, Muhammad, Andersson, Tommy, Saver, Jeffrey L, Mattle, Heinrich P, Bozorgchami, Hormozd, Ribó, Marc, and Zaidat, Osama O

Subjects
ISCHEMIC stroke, REPERFUSION, THROMBOLYTIC therapy, CEREBRAL infarction, INTRACRANIAL hemorrhage, LOGISTIC regression analysis
Abstract

Background: A considerable proportion of stroke patients have unfavorable outcomes despite substantial reperfusion during mechanical thrombectomy for large vessel occlusion. This study aimed to determine predictors of unfavorable outcomes despite substantial reperfusion (modified thrombolysis in cerebral infarction score of ≥2b). Methods: We conducted a post hoc analysis of Analysis of Revascularization in Ischemic Stroke With EmboTrap, a prospective, multicenter study on the efficacy of the EmboTrap revascularization device. We included patients with anterior large vessel occlusion, substantial reperfusion within three passes, and 3-month follow-up. Univariate and multivariate logistic regression analyses were performed to determine independent predictors of dependency or death (modified Rankin Score 3–6) at 90 days. Results: Of the 176 patients included in the study, 124 (70.45%) achieved modified Rankin Score of 0–2 at 90 days and 52 (29.6%) had modified Rankin Score of 3–6. On univariate analysis, patient age and initial National Institutes of Health Stroke Scale score were significantly higher in the modified Rankin Score of 3–6 groups (71.4 ± 11.3 years vs. 66.0 ± 13.1 years, 0.01; 18.9 ± 4.13 vs. 14.6 ± 4.36, p < 0.01, respectively). Mean number of passes and symptomatic intracranial hemorrhage were also higher in patients with modified Rankin Score of 3–6 (2.46 ± 1.42 vs. 1.65 ± 0.9, p < 0.01; 13.5% vs. 2.4%, p = 0.008). On multivariate analysis, initial National Institutes of Health Stroke Scale score and mean number of passes and were independent predictors of modified Rankin Score of 3–6 at 90 days. Conclusion: More severe initial neurologic deficit and higher number of passes in patients with substantial reperfusion were independent predictors of dependency or death. These findings highlight a reduction in the number of passes required to achieve reperfusion as a therapeutic target to improve the outcome after thrombectomy. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Benchmarking the Extent and Speed of Reperfusion: First Pass TICI 2c-3 Is a Preferred Endovascular Reperfusion Endpoint

Author

Yoo, Albert J., primary, Soomro, Jazba, additional, Andersson, Tommy, additional, Saver, Jeffrey L., additional, Ribo, Marc, additional, Bozorgchami, Hormozd, additional, Dabus, Guilherme, additional, Liebeskind, David S., additional, Jadhav, Ashutosh, additional, Mattle, Heinrich, additional, and Zaidat, Osama O., additional

Published
2021
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20. Abstract P496: Clot Characteristics in Mechanical Thrombectomy: Interim Analysis of the EXCELLENT Registry

Author

Nogueira, Raul, primary, Siddiqui, Adnan H, additional, De Meyer, Simon F, additional, Doyle, Karen, additional, Fiehler, Jens, additional, Hacke, Werner, additional, Hanel, Ricardo, additional, Liebeskind, David S, additional, Zaidat, Osama O, additional, Haussen, Diogo C, additional, Humphries, William, additional, Woodward, Keith B, additional, Jabbour, Pascal M, additional, Dashti, Shervin R, additional, Bozorgchami, Hormozd, additional, Levy, Elad, additional, Schirmer, Clemens M, additional, Taqi, Muhammad A, additional, De Leacy, Reade A, additional, Boor, Stephan, additional, Hussain, M. Shazam, additional, Puri, Ajit S, additional, Estrade, Laurent, additional, and Andersson, Tommy, additional

Published
2021
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22. Abstract P14: Per Pass Clot Retrieval Technique: Interim Analysis of the Excellent Registry

Author

Siddiqui, Adnan H, primary, Waqas, Muhammad, additional, Andersson, Tommy, additional, De Meyers, Simon F, additional, Fiehler, Jens, additional, Hacke, Werner, additional, Hanel, Ricardo, additional, Jovin, Tudor, additional, Liebeskind, David S, additional, Yoo, Albert J, additional, Zaidat, Osama O, additional, Haussen, Diogo C, additional, Inoa, Violiza, additional, Woodward, Keith, additional, Humphries, William E, additional, Jabbour, Pascal M, additional, Francois, Olivier, additional, Dashti, Shervin R, additional, Bozorgchami, Hormozd, additional, Levy, Elad, additional, Budzik, Ronald, additional, Schirmer, Clemens, additional, Taqi, Muhammad A, additional, Estrade, Laurent, additional, De Leacy, Reade A, additional, Boor, Stephan, additional, Hussain, Shazam, additional, Puri, Ajit S, additional, and Nogueira, Raul G, additional

Published
2021
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23. Balloon Guide Catheter Improves Revascularization and Clinical Outcomes With the Solitaire Device: Analysis of the North American Solitaire Acute Stroke Registry

Author

Nguyen, Thanh N., Malisch, Timothy, Castonguay, Alicia C., Gupta, Rishi, Sun, Chung-Huan J., Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey D., Linfante, Italo, Dabus, Guilherme, Marden, Franklin A., Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael T., Badruddin, Aamir, Taqi, Muhammad, Abraham, Michael G., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Roberta, Yoo, Albert J., Abou-Chebl, Alex, Chen, Peng R., Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, Issa, Mohammad A., Masoud, Hesham, Nogueira, Raul G., Norbash, Alexander M., and Zaidat, Osama O.

Published
2014
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24. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study

Author

de Havenon, Adam, Narata, Ana Paula, Amelot, Aymeric, Saver, Jeffrey L, Bozorgchami, Hormozd, Mattle, Heinrich Paul, Ribo, Marc, Andersson, Tommy, Zaidat, Osama, de Havenon, Adam, Narata, Ana Paula, Amelot, Aymeric, Saver, Jeffrey L, Bozorgchami, Hormozd, Mattle, Heinrich Paul, Ribo, Marc, Andersson, Tommy, and Zaidat, Osama

Abstract

The benefit of endovascular thrombectomy for acute ischemic stroke with M2 segment middle cerebral artery occlusion remains controversial, with uncertainty and paucity of data specific to this population. To compare outcomes between M1 and M2 occlusions in the Analysis of Revascularization in Ischemic Stroke with EmboTrap (ARISE II) trial. We performed a prespecified analysis of the ARISE II trial with the primary outcome of 90-day modified Rankin Scale score of 0-2, which we termed good outcome. Secondary outcomes included reperfusion rates and major adverse events. The primary predictor was M2 occlusion, which we compared with M1 occlusion. We included 183 patients, of whom 126 (69%) had M1 occlusion and 57 (31%) had M2 occlusion. There was no difference in the reperfusion rates or adverse events between M2 and M1 occlusions. The rate of good outcome was not different in M2 versus M1 occlusions (70.2% vs 69.7%, p=0.946). In a logistic regression model adjusted for age, sex, and baseline National Institutes of Health Stroke Scale score, M2 occlusions did not have a significantly different odds of good outcome compared with M1 occlusions (OR 0.94, 95% CI 0.47 to 1.88, p=0.87). In ARISE II, M2 occlusions achieved a 70.2% rate of good outcome at 90 days, which is above published rates for untreated M2 occlusions and superior to prior reports of M2 occlusions treated with endovascular thrombectomy. We also report similar rates of good outcome, successful reperfusion, death, and other adverse events when comparing the M1 and M2 occlusions

Published
2020

25. Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy : a United States and European perspective

Author

Zaidat, Osama, Ribo, Marc, Mattle, Heinrich Paul, Saver, Jeffrey L, Bozorgchami, Hormozd, Yoo, Albert J, Ehm, Alexandra, Kottenmeier, Emilie, Cameron, Heather L, Qadeer, Rana A, Andersson, Tommy, Zaidat, Osama, Ribo, Marc, Mattle, Heinrich Paul, Saver, Jeffrey L, Bozorgchami, Hormozd, Yoo, Albert J, Ehm, Alexandra, Kottenmeier, Emilie, Cameron, Heather L, Qadeer, Rana A, and Andersson, Tommy

Abstract

First-pass effect (FPE), restoring complete or near complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2c-3) in a single pass, is an independent predictor for good functional outcomes in the endovascular treatment of acute ischemic stroke. The economic implications of achieving FPE have not been assessed. To assess the economic impact of achieving complete or near complete reperfusion after the first pass. Post hoc analyses were conducted using ARISE II study data. The target population consisted of patients in whom mTICI 2c-3 was achieved, stratified into two groups: (1) mTICI 2c-3 achieved after the first pass (FPE group) or (2) after multiple passes (non-FPE group). Baseline characteristics, clinical outcomes, and healthcare resource use were compared between groups. Costs from peer-reviewed literature were applied to assess cost consequences from the perspectives of the United States (USA), France, Germany, Italy, Spain, Sweden, and United Kingdom (UK). Among patients who achieved mTICI 2c-3 (n=172), FPE was achieved in 53% (n=91). A higher proportion of patients in the FPE group reached good functional outcomes (90-day modified Rankin Scale score 0-2 80.46% vs 61.04%, p<0.01). The patients in the FPE group had a shorter mean length of stay (6.10 vs 9.48 days, p<0.01) and required only a single stent retriever, whereas 35% of patients in the non-FPE group required at least one additional device. Driven by improvement in clinical outcomes, the FPE group had lower procedural/hospitalization-related (24-33% reduction) and annual care (11-27% reduction) costs across all countries. FPE resulted in improved clinical outcomes, translating into lower healthcare resource use and lower estimated costs

Published
2020

28. First Pass Effect

Author

Zaidat, Osama O., primary, Castonguay, Alicia C., additional, Linfante, Italo, additional, Gupta, Rishi, additional, Martin, Coleman O., additional, Holloway, William E., additional, Mueller-Kronast, Nils, additional, English, Joey D., additional, Dabus, Guilherme, additional, Malisch, Tim W., additional, Marden, Franklin A., additional, Bozorgchami, Hormozd, additional, Xavier, Andrew, additional, Rai, Ansaar T., additional, Froehler, Michael T., additional, Badruddin, Aamir, additional, Nguyen, Thanh N., additional, Taqi, M. Asif, additional, Abraham, Michael G., additional, Yoo, Albert J., additional, Janardhan, Vallabh, additional, Shaltoni, Hashem, additional, Novakovic, Roberta, additional, Abou-Chebl, Alex, additional, Chen, Peng R., additional, Britz, Gavin W., additional, Sun, Chung-Huan J., additional, Bansal, Vibhav, additional, Kaushal, Ritesh, additional, Nanda, Ashish, additional, and Nogueira, Raul G., additional

Published
2018
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29. Clinical and Angiographic Outcomes with the Combined Local Aspiration and Retriever in the North American Solitaire Stent-Retriever Acute Stroke (NASA) Registry

Author

Malisch, Tim W., primary, Zaidat, Osama O., additional, Castonguay, Alicia C., additional, Marden, Franklin A., additional, Gupta, Rishi, additional, Sun, Chung-Huan J., additional, Martin, Coleman O., additional, Holloway, William E., additional, Mueller-Kronast, Nils, additional, English, Joey, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Bozorgchami, Hormozd, additional, Xavier, Andrew, additional, Rai, Ansaar T., additional, Froehler, Michael, additional, Badruddin, Aamir, additional, Nguyen, Thanh N., additional, Taqi, M. Asif, additional, Abraham, Michael G., additional, Janardhan, Vallabh, additional, Shaltoni, Hashem, additional, Novakovic, Robin, additional, Yoo, Albert J., additional, Abou-Chebl, Alex, additional, Chen, Peng Roc, additional, Britz, Gavin W., additional, Kaushal, Ritesh, additional, Nanda, Ashish, additional, and Nogueira, Raul G., additional

Published
2017
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30. Rescue Thrombectomy in Large Vessel Occlusion Strokes Leads to Better Outcomes than Intravenous Thrombolysis Alone: A ‘Real World' Applicability of the Recent Trials

Author

Nogueira, Raul G., primary, Zaidat, Osama O., additional, Castonguay, Alicia C., additional, Haussen, Diogo C., additional, Martin, Coleman O., additional, Holloway, William E., additional, Mueller-Kronast, Nils, additional, English, Joey, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Malisch, Tim W., additional, Marden, Franklin A., additional, Bozorgchami, Hormozd, additional, Xavier, Andrew, additional, Rai, Ansaar T., additional, Froehler, Michael T., additional, Badruddin, Aamir, additional, Nguyen, Thanh N., additional, Taqi, M. Asif, additional, Abraham, Michael G., additional, Janardhan, Vallabh, additional, Yoo, Albert J., additional, Shaltoni, Hashem, additional, Abou-Chebl, Alex, additional, Chen, Peng R., additional, Britz, Gavin W., additional, Novakovic, Roberta, additional, Nanda, Ashish, additional, Kaushal, Ritesh, additional, Issa, Mohammad A., additional, Frankel, Michael R., additional, and Gupta, Rishi, additional

Published
2016
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31. Abstract 197: Time Dependency and Relationship to Reperfusion Grade in Acute Ischemic Stroke

Author

Prabhakaran, Shyam, primary, Castonguay, Alicia C, additional, Gupta, Rishi, additional, Chung-Huan J. Sun, Chung-Huan, additional, Coleman Martin, Coleman, additional, Holloway, William, additional, Mueller-Kronast, Nils, additional, English, Joey, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Malisch, Tim, additional, Marden, Franklin, additional, Bozorgchami, Hormozd, additional, Xavier, Andrew, additional, Rai, Ansaar, additional, Froehler, Michael, additional, Badruddin, Aamir, additional, Abraham, Michael, additional, Janardhan, Vallabh, additional, Shaltoni, Hashem, additional, Yoo, Albert, additional, Abou-Chebl, Alex, additional, Chen, Peng, additional, Britz, Gavin, additional, Kaushal, Ritesh, additional, Nanda, Ashish, additional, Nogueira, Raul, additional, Nguyen, Thanh, additional, and Zaidat, Osama O, additional

Published
2015
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33. Clinical and Angiographic Outcomes with the Combined Local Aspiration and Retriever in the North American Solitaire Stent-Retriever Acute Stroke (NASA) Registry

Author

Malisch, Tim W., Zaidat, Osama O., Castonguay, Alicia C., Marden, Franklin A., Gupta, Rishi, Sun, Chung-Huan J., Martin, Coleman O., Holloway, William E., Mueller-Kronast, Nils, English, Joey, Linfante, Italo, Dabus, Guilherme, Bozorgchami, Hormozd, Xavier, Andrew, Rai, Ansaar T., Froehler, Michael, Badruddin, Aamir, Nguyen, Thanh N., Taqi, M. Asif, Abraham, Michael G., Janardhan, Vallabh, Shaltoni, Hashem, Novakovic, Robin, Yoo, Albert J., Abou-Chebl, Alex, Chen, Peng Roc, Britz, Gavin W., Kaushal, Ritesh, Nanda, Ashish, and Nogueira, Raul G.

Abstract

Background:Various techniques are used to enhance the results of mechanical thrombectomy with stent-retrievers, including proximal arrest with balloon guide catheter (BGC), conventional large bore proximal catheter (CGC), or in combination with local aspiration through a large-bore catheter positioned at the clot interface (Aspiration-Retriever Technique for Stroke [ARTS]). We evaluated the impact of ARTS in the North American Solitaire Acute Stroke (NASA) registry. Summary:Data on the use of the aspiration technique were available for 285 anterior circulation patients, of which 29 underwent ARTS technique, 131 CGC, and 125 BGC. Baseline demographics were comparable, except that ARTS patients are less likely to have hypertension or atrial fibrillation. The ARTS group had more ICA occlusions (41.4 vs. 22% in the BGC, p= 0.04 and 26% in CGC, p= 0.1) and less MCA/M1 occlusions (44.8 vs. 68% in BGC and 62% in CGC). Time from arterial puncture to reperfusion or end of procedure with ARTS was shorter than with CGC (54 vs. 91 min, p= 0.001) and was comparable to the BGC time (54 vs. 67, p= 0.11). Final degree of reperfusion was comparable among the groups (TICI [modified Thrombolysis in Cerebral Infarction] score 2b or higher was 72 vs. 70% for CGC vs. 78% for BGC). Procedural complications, mortality, and good clinical outcome at 90 days were similar between the groups. Key Messages:The ARTS mechanical thrombectomy in acute ischemic stroke patients appears to yield better results as compared to the use of CGCs with no significant difference when compared to BGC. This early ARTS technique NASA registry data are limited by the earlier generation distal large bore catheters and small sample size. Future studies should focus on the comparison of ARTS and BGC techniques.

Published
2018
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35. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study

Author

de Havenon, Adam, Narata, Ana Paula, Amelot, Aymeric, Saver, Jeffrey L, Bozorgchami, Hormozd, Mattle, Heinrich Paul, Ribo, Marc, Andersson, Tommy, and Zaidat, Osama O

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND The benefit of endovascular thrombectomy for acute ischemic stroke with M2 segment middle cerebral artery occlusion remains controversial, with uncertainty and paucity of data specific to this population. OBJECTIVE To compare outcomes between M1 and M2 occlusions in the Analysis of Revascularization in Ischemic Stroke with EmboTrap (ARISE II) trial. METHODS We performed a prespecified analysis of the ARISE II trial with the primary outcome of 90-day modified Rankin Scale score of 0-2, which we termed good outcome. Secondary outcomes included reperfusion rates and major adverse events. The primary predictor was M2 occlusion, which we compared with M1 occlusion. RESULTS We included 183 patients, of whom 126 (69%) had M1 occlusion and 57 (31%) had M2 occlusion. There was no difference in the reperfusion rates or adverse events between M2 and M1 occlusions. The rate of good outcome was not different in M2 versus M1 occlusions (70.2% vs 69.7%, p=0.946). In a logistic regression model adjusted for age, sex, and baseline National Institutes of Health Stroke Scale score, M2 occlusions did not have a significantly different odds of good outcome compared with M1 occlusions (OR 0.94, 95% CI 0.47 to 1.88, p=0.87). CONCLUSION In ARISE II, M2 occlusions achieved a 70.2% rate of good outcome at 90 days, which is above published rates for untreated M2 occlusions and superior to prior reports of M2 occlusions treated with endovascular thrombectomy. We also report similar rates of good outcome, successful reperfusion, death, and other adverse events when comparing the M1 and M2 occlusions.

36. Abstract WP85.

Author

Beadell, Noah, Bozorgchami, Hormozd, and Fields, Jeremy

Published
2013

37. Abstract WP25.

Author

Bozorgchami, Hormozd, Fields, Jeremy, Walker, Gary, Jahans, Cindy, and Lutsep, Helmi

Published
2013

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