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1. Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

Author

Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Hernández-Gallego, Jesús [0000-0002-9410-1720], Llamas-Velasco, Sara [0000-0002-9174-2610], Bermejo-Pareja, Felix [0000-0002-5413-232X], Vega, Saturio [0000-0001-5034-0140], Tapias-Merino, Ester [0000-0002-8720-7375], Rodríguez-Sánchez, Emiliano [0000-0003-3667-7155], Boycheva, Elina [0000-0002-9506-8491], González-Serrano, José Ignacio [0000-0003-0795-3026], Vizcaino Sánchez-Rodrigo, José-María [0000-0001-9464-9393], Contador, Israel [0000-0002-7841-1307], Garcia-Ptacek, Sara [0000-0002-1537-6129], Sierra-Hidalgo, Fernando [0000-0003-4044-8304], Carro, Eva [0000-0002-6504-4579], Villarejo-Galende, Alberto [0000-0002-6834-7620], Benito-León, Julián [0000-0002-1769-4809], Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Félix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, González-Serrano, José Ignacio, Gil-García, Juan-Francisco, Trincado, Rocío, Vizcaino Sánchez-Rodrigo, José-María, Cacho, Jesús, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Cubo, Esther, Carro, Eva, Villarejo-Galende, Alberto, García García-Patino, Rosalía, Benito-León, Julián, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Hernández-Gallego, Jesús [0000-0002-9410-1720], Llamas-Velasco, Sara [0000-0002-9174-2610], Bermejo-Pareja, Felix [0000-0002-5413-232X], Vega, Saturio [0000-0001-5034-0140], Tapias-Merino, Ester [0000-0002-8720-7375], Rodríguez-Sánchez, Emiliano [0000-0003-3667-7155], Boycheva, Elina [0000-0002-9506-8491], González-Serrano, José Ignacio [0000-0003-0795-3026], Vizcaino Sánchez-Rodrigo, José-María [0000-0001-9464-9393], Contador, Israel [0000-0002-7841-1307], Garcia-Ptacek, Sara [0000-0002-1537-6129], Sierra-Hidalgo, Fernando [0000-0003-4044-8304], Carro, Eva [0000-0002-6504-4579], Villarejo-Galende, Alberto [0000-0002-6834-7620], Benito-León, Julián [0000-0002-1769-4809], Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Félix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, González-Serrano, José Ignacio, Gil-García, Juan-Francisco, Trincado, Rocío, Vizcaino Sánchez-Rodrigo, José-María, Cacho, Jesús, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Cubo, Esther, Carro, Eva, Villarejo-Galende, Alberto, García García-Patino, Rosalía, and Benito-León, Julián

Abstract

Background The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. Objective The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Methods A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. Results In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Conclusions Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection).

Published
2019

2. Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

Author

Hernández-Gallego, Jesús, primary, Llamas-Velasco, Sara, additional, Bermejo-Pareja, Felix, additional, Vega, Saturio, additional, Tapias-Merino, Ester, additional, Rodríguez-Sánchez, Emiliano, additional, Boycheva, Elina, additional, Serrano, José Ignacio, additional, Gil-García, Juan-Francisco, additional, Trincado, Rocio, additional, Sánchez-Rodrigo, José-María Vizcaino, additional, Cacho, Jesús, additional, Contador, Israel, additional, Garcia-Ptacek, Sara, additional, Sierra-Hidalgo, Fernando, additional, Cubo, Esther, additional, Carro, Eva, additional, Villarejo-Galende, Alberto, additional, García García-Patino, Rosalía, additional, and Benito-León, Julián, additional

Published
2019
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3. Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study

Author

Sara Llamas-Velasco, Juan-Francisco Gil-García, Alberto Villarejo-Galende, Esther Cubo, Jesús Hernández-Gallego, Ester Tapias-Merino, Eva Carro, Julián Benito-León, Sara Garcia-Ptacek, José Ignacio Serrano, Jesus L. Cacho, Emiliano Rodríguez-Sánchez, Elina Boycheva, Rosalía García García-Patino, José-María Vizcaino Sánchez-Rodrigo, Saturio Vega, Israel Contador, Félix Bermejo-Pareja, F. Sierra-Hidalgo, Rocío Trincado, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Hernández-Gallego, Jesús [0000-0002-9410-1720], Llamas-Velasco, Sara [0000-0002-9174-2610], Bermejo-Pareja, Felix [0000-0002-5413-232X], Vega, Saturio [0000-0001-5034-0140], Tapias-Merino, Ester [0000-0002-8720-7375], Rodríguez-Sánchez, Emiliano [0000-0003-3667-7155], Boycheva, Elina [0000-0002-9506-8491], González-Serrano, José Ignacio [0000-0003-0795-3026], Vizcaino Sánchez-Rodrigo, José-María [0000-0001-9464-9393], Contador, Israel [0000-0002-7841-1307], Garcia-Ptacek, Sara [0000-0002-1537-6129], Sierra-Hidalgo, Fernando [0000-0003-4044-8304], Carro, Eva [0000-0002-6504-4579], Villarejo-Galende, Alberto [0000-0002-6834-7620], Benito-León, Julián [0000-0002-1769-4809], Hernández-Gallego, Jesús, Llamas-Velasco, Sara, Bermejo-Pareja, Felix, Vega, Saturio, Tapias-Merino, Ester, Rodríguez-Sánchez, Emiliano, Boycheva, Elina, González-Serrano, José Ignacio, Vizcaino Sánchez-Rodrigo, José-María, Contador, Israel, Garcia-Ptacek, Sara, Sierra-Hidalgo, Fernando, Carro, Eva, Villarejo-Galende, Alberto, and Benito-León, Julián

Subjects
Longitudinal study, medicine.medical_specialty, 020205 medical informatics, Demographics, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, mild cognitive impairment, 0202 electrical engineering, electronic engineering, information engineering, medicine, Dementia, 030212 general & internal medicine, NEDICES, Medical diagnosis, Original Paper, business.industry, pilot study, Headache, General Medicine, medicine.disease, Biobank, stroke, Test (assessment), population-based study, Family medicine, Parkinson’s disease, Essential tremor, Observational study, observational study, Lifestyle habits, business
Abstract

Background The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank. Objective The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Methods A selection of patients and participants of the planned NEDICES-2 underwent face-to-face interviews including a comprehensive questionnaire on demographics, current medications, medical conditions, and lifestyle habits. Biological samples (blood, saliva, urine, and hair) were also obtained. Furthermore, every participant was examined by a neurologist. Results In this pilot study, 567 study participants were enrolled (196 from hospitals and 371 from primary care physician lists). Of these 567, 310 completed all study procedures (questionnaires and the neurological evaluation). The study was time-consuming for several primary care physicians. Hence, a few primary care physicians from some areas refused to participate, which led to a reconfiguration of study areas. In addition, the central biobank needed to be supplemented by the biobanks of local Spanish National Health System hospitals. Conclusions Population-based epidemiological surveys, such as the NEDICES-2, require a pilot study to evaluate the feasibility of all aspects of a future field study (population selection, methods and instruments to be used, neurological diagnosis agreement, and data collection)., Our thanks to all collaborators in this feasibility pilot study, the Instituto de Salud Carlos III and the Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), and the two hospital computer experts (Victoria Garcia Baquero and Teresa Garcia Morales), who created the website (http://nedices2.ciberned.com/estudio-de-salud-nedices-2/). We would also like to thank Miss Jennifer Gates for the editing and proofreading of the manuscript.

Published
2019

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