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1. Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries.

Author

Manasyan, Albert, Salas, Ariel, Nolen, Tracy, Chomba, Elwyn, Mazariegos, Manolo, Tshefu Kitoto, Antoinette, Saleem, Sarah, Naqvi, Farnaz, Hambidge, K, Goco, Norman, McClure, Elizabeth, Biasini, Fred, Goldenberg, Robert, Bose, Carl, Koso-Thomas, Marion, Krebs, Nancy, Carlo, Waldemar, and Wallander, Jan

Subjects
community child health, developmental neurology & neurodisability, paediatric neurology, Child, Infant, Humans, Child, Preschool, Communication, Guatemala, Health Personnel, Income, Neurodevelopmental Disorders
Abstract

OBJECTIVE: The Bayley Scales of Infant Development (BSID) is the most used diagnostic tool to identify neurodevelopmental disorders in children under age 3 but is challenging to use in low-resource countries. The Ages and Stages Questionnaire (ASQ) is an easy-to-use, low-cost clinical tool completed by parents/caregivers that screens children for developmental delay. The objective was to determine the performance of ASQ as a screening tool for neurodevelopmental impairment when compared with BSID second edition (BSID-II) for the diagnosis of moderate-to-severe neurodevelopmental impairment among infants at 12 and 18 months of age in low-resource countries. METHODS: Study participants were recruited as part of the First Bites Complementary Feeding trial from the Democratic Republic of Congo, Zambia, Guatemala and Pakistan between October 2008 and January 2011. Study participants underwent neurodevelopmental assessment by trained personnel using the ASQ and BSID-II at 12 and 18 months of age. RESULTS: Data on both ASQ and BSID-II assessments of 1034 infants were analysed. Four of five ASQ domains had specificities greater than 90% for severe neurodevelopmental delay at 18 months of age. Sensitivities ranged from 23% to 62%. The correlations between ASQ communications subscale and BSID-II Mental Development Index (MDI) (r=0.38) and between ASQ gross motor subscale and BSID-II Psychomotor Development Index (PDI) (r=0.33) were the strongest correlations found. CONCLUSION: At 18 months, ASQ had high specificity but moderate-to-low sensitivity for BSID-II MDI and/or PDI

Published
2023

2. Building a predictive model of low birth weight in low- and middle-income countries: a prospective cohort study

Author

Patterson, Jackie K., Thorsten, Vanessa R., Eggleston, Barry, Nolen, Tracy, Lokangaka, Adrien, Tshefu, Antoinette, Goudar, Shivaprasad S., Derman, Richard J., Chomba, Elwyn, Carlo, Waldemar A., Mazariegos, Manolo, Krebs, Nancy F., Saleem, Sarah, Goldenberg, Robert L., Patel, Archana, Hibberd, Patricia L., Esamai, Fabian, Liechty, Edward A., Haque, Rashidul, Petri, Bill, Koso-Thomas, Marion, McClure, Elizabeth M., Bose, Carl L., and Bauserman, Melissa

Published
2023
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3. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants

Author

Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S, DeMauro, Sara B, Van Meurs, Krisa P, Foglia, Elizabeth E, Lakshminrusimha, Satyan, Walsh, Michele C, Watterberg, Kristi L, Wyckoff, Myra H, Das, Abhik, Handley, Sara C, Network, Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Laptook, R, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, St. Pierre, Lucille, Hibbs, Anna Maria, Truog, William E, Pallotto, Eugenia K, Parimi, Prabhu S, Gauldin, Cheri, Holmes, Anne, Knutson, Allison, Gaetano, Lisa, Poindexter, Brenda B, Schibler, Kurt, Merhar, Stephanie L, Grisby, Cathy, Kirker, Kristin, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D, Rhodes-Ryan, Ginger, White, Donna, Carlton, David P, Patel, Ravi M, Loggins, Yvonne, Mackie, Colleen, Bottcher, Diane I, Bremer, Andrew A, Higgins, Rosemary D, Archer, Stephanie Wilson, Sokol, Gregory M, Herron, Dianne E, Tyson, Jon E, Khan, Amir M, Kennedy, Kathleen A, Pedrozza, Claudia, Eason, Elizabeth, Stephens, Emily K, McDavid, Georgia E, Martin, Karen, Hall, Donna, Wright, Sharon L, Sánchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Clark, Erna, Gutentag, Julie, Park, Courtney, Shadd, Julie C, Stein, Melanie, Baugher, Hallie, McCool, Jacqueline, Gantz, Marie G, Bann, Carla M, Wallace, Dennis, Zaterka-Baxter, Kristin M, Gabrio, Jenna, Leblond, David, Auman, Jeanette O'Donnell, Stevenson, David K, Chock, Valerie Y, Ball, M Bethany, Proud, Melinda S, Reichert, Elizabeth N, Williams, R Jordan, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, McNair, Tara, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F, Colaizy, Tarah T, and Ellsbury, Dan L

Subjects
Paediatrics, Biomedical and Clinical Sciences, Prevention, Preterm, Low Birth Weight and Health of the Newborn, Infant Mortality, Clinical Research, Neurosciences, Cardiovascular, Clinical Trials and Supportive Activities, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Reproductive health and childbirth, Good Health and Well Being, Cerebral Intraventricular Hemorrhage, Constriction, Female, Gestational Age, Hospital Mortality, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Retrospective Studies, Umbilical Cord, Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network, Neonatal Research Network, intraventricular hemorrhage, placental transfusion, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo compare in-hospital outcomes after umbilical cord milking vs delayed cord clamping among infants

Published
2021

4. Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women's and Children's Health Research

Author

Patterson, Jackie K, Neuwahl, Simon, Goco, Norman, Moore, Janet, Goudar, Shivaprasad S, Derman, Richard J, Hoffman, Matthew, Metgud, Mrityunjay, Somannavar, Manjunath, Kavi, Avinash, Okitawutshu, Jean, Lokangaka, Adrien, Tshefu, Antoinette, Bose, Carl L, Mwapule, Abigail, Mwenechanya, Musaku, Chomba, Elwyn, Carlo, Waldemar A, Chicuy, Javier, Figueroa, Lester, Krebs, Nancy F, Jessani, Saleem, Saleem, Sarah, Goldenberg, Robert L, Kurhe, Kunal, Das, Prabir, Patel, Archana, Hibberd, Patricia L, Achieng, Emmah, Nyongesa, Paul, Esamai, Fabian, Bucher, Sherri, Liechty, Edward A, Bresnahan, Brian W, Koso-Thomas, Marion, and McClure, Elizabeth M

Published
2023
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5. Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants

Author

Bajaj, Monika, Natarajan, Girija, Shankaran, Seetha, Wyckoff, Myra, Laptook, R, Bell, Edward F, Stoll, Barbara J, Carlo, Waldemar A, Vohr, Betty R, Saha, Shampa, Van Meurs, Krisa P, Sanchez, Pablo J, D'Angio, Carl T, Higgins, Rosemary D, Das, Abhik, Newman, Nancy, Walsh, Michele C, Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research, Polin, Richard A, Keszler, Martin, Hensman, Angelita M, Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Poindexter, Brenda B, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Kandefer, Sarah, Auman, Jeanette O'Donnell, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, Brumbaugh, Jane E, Johnson, Karen J, Campbell, Donia B, Walker, Jacky R, Watterberg, Kristi L, Ohls, Robin K, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B, Cook, Noah, and Chaudhary, Aasma S

Subjects
Paediatrics, Biomedical and Clinical Sciences, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Lung, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cardiopulmonary Resuscitation, Continuous Positive Airway Pressure, Delivery Rooms, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Intubation, Intratracheal, Male, Outcome Assessment, Health Care, Oxygen Inhalation Therapy, Prospective Studies, Registries, Risk Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, CPR, delivery room, endotracheal intubation, moderate Preterm, oxygen, resuscitation, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesTo describe the frequency and extent of delivery room resuscitation and evaluate the association of delivery room resuscitation with neonatal outcomes in moderately preterm (MPT) infants.Study designThis was an observational cohort study of MPT infants delivered at 290/7 to 336/7 weeks' gestational age (GA) enrolled in the Neonatal Research Network MPT registry. Infants were categorized into 5 groups based on the highest level of delivery room intervention: routine care, oxygen and/or continuous positive airway pressure, bag and mask ventilation, endotracheal intubation, and cardiopulmonary resuscitation including chest compressions and/or epinephrine use. The association of antepartum and intrapartum risk factors and discharge outcomes with the intensity of resuscitation was evaluated.ResultsOf 7014 included infants, 1684 (24.0%) received routine care and no additional resuscitation, 2279 (32.5%) received oxygen or continuous positive airway pressure, 1831 (26.1%) received bag and mask ventilation, 1034 (14.7%) underwent endotracheal intubation, and 186 (2.7%) received cardiopulmonary resuscitation. Among the antepartum and intrapartum factors, increasing GA, any exposure to antenatal steroids and prolonged rupture of membranes decreased the likelihood of receipt of all levels of resuscitation. Infants who were small for GA (SGA) had increased risk of delivery room resuscitation. Among the neonatal outcomes, respiratory support at 28 days, days to full oral feeds and length of stay were significantly associated with the intensity of delivery room resuscitation. Higher intensity of resuscitation was associated with increased risk of mortality.ConclusionsThe majority of MPT infants receive some level of delivery room resuscitation. Increased intensity of delivery room interventions was associated with prolonged respiratory and nutritional support, increased mortality, and a longer length of stay.

Published
2018

6. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Laptook, R, Bell, Edward F, Shankaran, Seetha, Boghossian, Nansi S, Wyckoff, Myra H, Kandefer, Sarah, Walsh, Michele, Saha, Shampa, Higgins, Rosemary, Network, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research, Polin, Richard A, Keszler, Martin, Vohr, Betty R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A, Hibbs, Anna Marie, Newman, Nancy S, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F, Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Auten, Kathy J, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Sokol, Gregory M, Herron, Dianne E, Lemons, James A, Appel, Diana D, Miller, Lucy C, Sanchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W Kenneth, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Hastings, Betty K, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, and Brumbaugh, Jane E

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Body Temperature, Female, Fever, Hospital Mortality, Humans, Hypothermia, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Patient Admission, Risk Factors, United States, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network, hyperthermia, hypothermia, prematurity, survival, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, 37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality.ConclusionsLow and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

Published
2018

7. The efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries

Author

Bauserman, Melissa, Leuba, Sequoia I., Hemingway-Foday, Jennifer, Nolen, Tracy L., Moore, Janet, McClure, Elizabeth M., Lokangaka, Adrien, Tsehfu, Antoinette, Patterson, Jackie, Liechty, Edward A., Esamai, Fabian, Carlo, Waldemar A., Chomba, Elwyn, Goldenberg, Robert L., Saleem, Sarah, Jessani, Saleem, Koso-Thomas, Marion, Hoffman, Matthew, Derman, Richard J., Meshnick, Steven R., and Bose, Carl L.

Published
2022
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8. Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings

Author

Chiwila, Melody K., primary, Krebs, Nancy F., additional, Manasyan, Albert, additional, Chomba, Elwyn, additional, Mwenechanya, Musaku, additional, Mazariegos, Manolo, additional, Sami, Neelofar, additional, Pasha, Omrana, additional, Tshefu, Antoinette, additional, Lokangaka, Adrien, additional, Goldenberg, Robert L., additional, Bose, Carl L., additional, Koso-Thomas, Marion, additional, Goco, Norman, additional, Do, Barbara T., additional, McClure, Elizabeth M., additional, Hambidge, K. Michael, additional, Westcott, Jamie E., additional, and Carlo, Waldemar A., additional

Published
2024
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9. Setting research priorities to improve global newborn health and prevent stillbirths by 2025.

Author

Yoshida, Sachiyo, Martines, José, Lawn, Joy E, Wall, Stephen, Souza, Joăo Paulo, Rudan, Igor, Cousens, Simon, neonatal health research priority setting group, Aaby, Peter, Adam, Ishag, Adhikari, Ramesh Kant, Ambalavanan, Namasivayam, Arifeen, Shams Ei, Aryal, Dhana Raj, Asiruddin, Sk, Baqui, Abdullah, Barros, Aluisio Jd, Benn, Christine S, Bhandari, Vineet, Bhatnagar, Shinjini, Bhattacharya, Sohinee, Bhutta, Zulfiqar A, Black, Robert E, Blencowe, Hannah, Bose, Carl, Brown, Justin, Bührer, Christoph, Carlo, Wally, Cecatti, Jose Guilherme, Cheung, Po-Yin, Clark, Robert, Colbourn, Tim, Conde-Agudelo, Agustin, Corbett, Erica, Czeizel, Andrew E, Das, Abhik, Day, Louise Tina, Deal, Carolyn, Deorari, Ashok, Dilmen, Uğur, English, Mike, Engmann, Cyril, Esamai, Fabian, Fall, Caroline, Ferriero, Donna M, Gisore, Peter, Hazir, Tabish, Higgins, Rosemary D, Homer, Caroline Se, Hoque, DE, Irgens, Lorentz, Islam, MT, de Graft-Johnson, Joseph, Joshua, Martias Alice, Keenan, William, Khatoon, Soofia, Kieler, Helle, Kramer, Michael S, Lackritz, Eve M, Lavender, Tina, Lawintono, Laurensia, Luhanga, Richard, Marsh, David, McMillan, Douglas, McNamara, Patrick J, Mol, Ben Willem J, Molyneux, Elizabeth, Mukasa, GK, Mutabazi, Miriam, Nacul, Luis Carlos, Nakakeeto, Margaret, Narayanan, Indira, Olusanya, Bolajoko, Osrin, David, Paul, Vinod, Poets, Christian, Reddy, Uma M, Santosham, Mathuram, Sayed, Rubayet, Schlabritz-Loutsevitch, Natalia E, Singhal, Nalini, Smith, Mary Alice, Smith, Peter G, Soofi, Sajid, Spong, Catherine Y, Sultana, Shahin, Tshefu, Antoinette, van Bel, Frank, Gray, Lauren Vestewig, Waiswa, Peter, Wang, Wei, Williams, Sarah LA, Wright, Linda, Zaidi, Anita, Zhang, Yanfeng, Zhong, Nanbert, Zuniga, Isabel, and Bahl, Rajiv

Subjects
neonatal health research priority setting group, Public Health and Health Services
Abstract

BackgroundIn 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.MethodsWe used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.ResultsNine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.ConclusionThese findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2016

10. Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Author

Yoshida, Sachiyo, Martines, José, Lawn, Joy E, Wall, Stephen, Souza, Joăo Paulo, Rudan, Igor, Cousens, Simon, Aaby, Peter, Adam, Ishag, Adhikari, Ramesh Kant, Ambalavanan, Namasivayam, Arifeen, Shams EI, Aryal, Dhana Raj, Asiruddin, Sk, Baqui, Abdullah, Barros, Aluisio JD, Benn, Christine S, Bhandari, Vineet, Bhatnagar, Shinjini, Bhattacharya, Sohinee, Bhutta, Zulfiqar A, Black, Robert E, Blencowe, Hannah, Bose, Carl, Brown, Justin, Bührer, Christoph, Carlo, Wally, Cecatti, Jose Guilherme, Cheung, Po–Yin, Clark, Robert, Colbourn, Tim, Conde–Agudelo, Agustin, Corbett, Erica, Czeizel, Andrew E, Das, Abhik, Day, Louise Tina, Deal, Carolyn, Deorari, Ashok, Dilmen, Uğur, English, Mike, Engmann, Cyril, Esamai, Fabian, Fall, Caroline, Ferriero, Donna M, Gisore, Peter, Hazir, Tabish, Higgins, Rosemary D, Homer, Caroline SE, Hoque, DE, Irgens, Lorentz, Islam, MT, de Graft–Johnson, Joseph, Joshua, Martias Alice, Keenan, William, Khatoon, Soofia, Kieler, Helle, Kramer, Michael S, Lackritz, Eve M, Lavender, Tina, Lawintono, Laurensia, Luhanga, Richard, Marsh, David, McMillan, Douglas, McNamara, Patrick J, Mol, Ben Willem J, Molyneux, Elizabeth, Mukasa, GK, Mutabazi, Miriam, Nacul, Luis Carlos, Nakakeeto, Margaret, Narayanan, Indira, Olusanya, Bolajoko, Osrin, David, Paul, Vinod, Poets, Christian, Reddy, Uma M, Santosham, Mathuram, Sayed, Rubayet, Schlabritz–Loutsevitch, Natalia E, Singhal, Nalini, Smith, Mary Alice, Smith, Peter G, Soofi, Sajid, Spong, Catherine Y, Sultana, Shahin, Tshefu, Antoinette, van Bel, Frank, Gray, Lauren Vestewig, Waiswa, Peter, Wang, Wei, Williams, Sarah LA, Wright, Linda, Zaidi, Anita, Zhang, Yanfeng, Zhong, Nanbert, Zuniga, Isabel, and Bahl, Rajiv

Subjects
Public Health, Health Sciences, Infant Mortality, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, neonatal health research priority setting group, Public Health and Health Services, Public health
Abstract

BackgroundIn 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.MethodsWe used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.ResultsNine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.ConclusionThese findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Published
2015

11. A multifaceted intervention to improve syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cluster randomised controlled trial

Author

Althabe, Fernando, Chomba, Elwyn, Tshefu, Antoinette K, Banda, Ernest, Belizán, María, Bergel, Eduardo, Berrueta, Mabel, Bertrand, Jane, Bose, Carl, Cafferata, Maria Luisa, Carlo, Waldemar A, Ciganda, Alvaro, Donnay, France, García Elorrio, Ezequiel, Gibbons, Luz, Klein, Karen, Liljestrand, Jerker, Lusamba, Paul D, Mavila, Arlette K, Mazzoni, Agustina, Nkamba, Dalau M, Mwanakalanga, Friday H, Mwapule Tembo, Abigail, Mwenechanya, Musaku, Pyne-Mercier, Lee, Spira, Cintia, Wetshikoy, Jean D, Xiong, Xu, and Buekens, Pierre

Published
2019
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12. A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial

Author

Hambidge, K Michael, Westcott, Jamie E, Garcés, Ana, Figueroa, Lester, Goudar, Shivaprasad S, Dhaded, Sangappa M, Pasha, Omrana, Ali, Sumera A, Tshefu, Antoinette, Lokangaka, Adrien, Derman, Richard J, Goldenberg, Robert L, Bose, Carl L, Bauserman, Melissa, Koso-Thomas, Marion, Thorsten, Vanessa R, Sridhar, Amaanti, Stolka, Kristen, Das, Abhik, McClure, Elizabeth M, and Krebs, Nancy F

Published
2019
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13. Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with malaria

Author

Morris, Carrie A, Onyamboko, Marie A, Capparelli, Edmund, Koch, Matthew A, Atibu, Joseph, Lokomba, Vicky, Douoguih, Macaya, Hemingway-Foday, Jennifer, Wesche, David, Ryder, Robert W, Bose, Carl, Wright, Linda, Tshefu, Antoinette K, Meshnick, Steven, and Fleckenstein, Lawrence

Abstract

Abstract Background The World Health Organization endorses the use of artemisinin-based combination therapy for treatment of acute uncomplicated falciparum malaria in the second and third trimesters of pregnancy. However, the effects of pregnancy on the pharmacokinetics of artemisinin derivatives, such as artesunate (AS), are poorly understood. In this analysis, the population pharmacokinetics of oral AS, and its active metabolite dihydroartemisinin (DHA), were studied in pregnant and non-pregnant women at the Kingasani Maternity Clinic in the DRC. Methods Data were obtained from 26 pregnant women in the second (22 - 26 weeks) or the third (32 - 36 weeks) trimester of pregnancy and from 25 non-pregnant female controls. All subjects received 200 mg AS. Plasma AS and DHA were measured using a validated LC-MS method. Estimates for pharmacokinetic and variability parameters were obtained through nonlinear mixed effects modelling. Results A simultaneous parent-metabolite model was developed consisting of mixed zero-order, lagged first-order absorption of AS, a one-compartment model for AS, and a one-compartment model for DHA. Complete conversion of AS to DHA was assumed. The model displayed satisfactory goodness-of-fit, stability, and predictive ability. Apparent clearance (CL/F) and volume of distribution (V/F) estimates, with 95% bootstrap confidence intervals, were as follows: 195 L (139-285 L) for AS V/F, 895 L/h (788-1045 L/h) for AS CL/F, 91.4 L (78.5-109 L) for DHA V/F, and 64.0 L/h (55.1-75.2 L/h) for DHA CL/F. The effect of pregnancy on DHA CL/F was determined to be significant, with a pregnancy-associated increase in DHA CL/F of 42.3% (19.7 - 72.3%). Conclusions In this analysis, pharmacokinetic modelling suggests that pregnant women have accelerated DHA clearance compared to non-pregnant women receiving orally administered AS. These findings, in conjunction with a previous non-compartmental analysis of the modelled data, provide further evidence that higher AS doses would be required to maintain similar DHA levels in pregnant women as achieved in non-pregnant controls.

Published
2011

14. Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC

Author

Onyamboko, Marie A, Meshnick, Steven R, Fleckenstein, Lawrence, Koch, Matthew A, Atibu, Joseph, Lokomba, Victor, Douoguih, Macaya, Hemingway-Foday, Jennifer, Wesche, David, Ryder, Robert W, Bose, Carl, Wright, Linda L, Tshefu, Antoinette K, and Capparelli, Edmund V

Abstract

Abstract Background In many malaria-endemic countries, increasing resistance may soon compromise the efficacy of sulphadoxine-pyrimethamine (SP) for intermittent preventative treatment (IPT) of malaria in pregnancy. Artemisinin-based IPT regimens represent a promising potential alternative to SP. Pharmacokinetic and safety data supporting the use of artemisinin derivatives in pregnancy are urgently needed. Methods Subjects included pregnant women with asymptomatic falciparum parasitaemia between 22-26 weeks (n = 13) or 32-36 weeks gestation (n = 13), the same women at three months postpartum, and 25 non-pregnant parasitaemic controls. All subjects received 200 mg orally administered AS. Plasma total and free levels of AS and its active metabolite DHA were determined using a validated LC-MS method. Non-compartmental pharmacokinetic analysis was performed using standard methods. Results All pregnant women delivered live babies. The median birth weight was 3025 grams [range 2130, 3620]; 2 of 26 babies had birth weights less than 2500 grams. Rates of parasite clearance by 12 hours post-dose were high and comparable among the groups. Rapid elimination of AS was observed in all three groups. The 90% CI for the pregnancy:postpartum ratio of geometric means for total and free AUC fell within the pre-specified 0.66 - 1.50 therapeutic equivalence interval. However, more pronounced pharmacokinetic differences were observed between the pregnancy and control subjects, with the 90% CI for the pregnancy:control ratio of geometric means for both total 0.68 (90% CI 0.57-0.81) and free AUC 0.78 (90% CI 0.63-0.95) not fully contained within the 0.66 - 1.50 interval. All subjects cleared parasites rapidly, and there was no difference in the percentage of women who were parasitaemic 12 hours after dosing. Conclusions A single dose of orally administered AS was found to be both effective and without adverse effects in this study of second and third trimester pregnant women in the DRC. Although DHA AUC during pregnancy and postpartum were similar, the AUC for the pregnant group was less than the non-pregnant controls. The findings of this study suggest that additional studies on the pharmacokinetics of AS in pregnant women are needed. Trial Registration ClinicalTrials.gov: NCT00538382

Published
2011

15. Prevention of maternal and neonatal death/infections with a single oral dose of azithromycin in women in labour in low-income and middle-income countries (A-PLUS): a study protocol for a multinational, randomised placebo-controlled clinical trial

Author

Hemingway-Foday, Jennifer, primary, Tita, Alan, additional, Chomba, Elwyn, additional, Mwenechanya, Musaku, additional, Mweemba, Trecious, additional, Nolen, Tracy, additional, Lokangaka, Adrien, additional, Tshefu Kitoto, Antoinette, additional, Lomendje, Gustave, additional, Hibberd, Patricia L, additional, Patel, Archana, additional, Das, Prabir Kumar, additional, Kurhe, Kunal, additional, Goudar, Shivaprasad S, additional, Kavi, Avinash, additional, Metgud, Mrityunjay, additional, Saleem, Sarah, additional, Tikmani, Shiyam S, additional, Esamai, Fabian, additional, Nyongesa, Paul, additional, Sagwe, Amos, additional, Figueroa, Lester, additional, Mazariegos, Manolo, additional, Billah, Sk Masum, additional, Haque, Rashidul, additional, Shahjahan Siraj, Md, additional, Goldenberg, Robert L, additional, Bauserman, Melissa, additional, Bose, Carl, additional, Liechty, Edward A, additional, Ekhaguere, Osayame A, additional, Krebs, Nancy F, additional, Derman, Richard, additional, Petri, William A, additional, Koso-Thomas, Marion, additional, McClure, Elizabeth, additional, and Carlo, Waldemar A, additional

Published
2023
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16. Institutional deliveries and stillbirth and neonatal mortality in the Global Network's Maternal and Newborn Health Registry

Author

Goudar, Shivaprasad S., Goco, Norman, Somannavar, Manjunath S., Kavi, Avinash, Vernekar, Sunil S., Tshefu, Antoinette, Chomba, Elwyn, Garces, Ana L., Saleem, Sarah, Naqvi, Farnaz, Patel, Archana, Esamai, Fabian, Bose, Carl L., Carlo, Waldemar A., Krebs, Nancy F., Hibberd, Patricia L., Liechty, Edward A., Koso-Thomas, Marion, Nolen, Tracy L., Moore, Janet, Iyer, Pooja, McClure, Elizabeth M., Goldenberg, Robert L., and Derman, Richard J.

Published
2020
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17. Cesarean birth in the Global Network for Women’s and Children’s Health Research: trends in utilization, risk factors, and subgroups with high cesarean birth rates

Author

Harrison, Margo S., Garces, Ana L., Goudar, Shivaprasad S., Saleem, Sarah, Moore, Janet L., Esamai, Fabian, Patel, Archana B., Chomba, Elwyn, Bose, Carl L., Liechty, Edward A., Krebs, Nancy F., Derman, Richard J., Hibberd, Patricia L., Carlo, Waldemar A., Tshefu, Antoinette, Koso-Thomas, Marion, McClure, Elizabeth M., and Goldenberg, Robert L.

Published
2020
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18. Why are the Pakistani maternal, fetal and newborn outcomes so poor compared to other low and middle-income countries?

Author

Aziz, Aleha, Saleem, Sarah, Nolen, Tracy L., Pradhan, Nousheen Akber, McClure, Elizabeth M., Jessani, Saleem, Garces, Ana L., Hibberd, Patricia L., Moore, Janet L., Goudar, Shivaprasad S., Dhaded, Sangappa M., Esamai, Fabian, Tenge, Constance, Patel, Archana B., Chomba, Elwyn, Mwenechanya, Musaku, Bose, Carl L., Liechty, Edward A., Krebs, Nancy F., Derman, Richard J., Carlo, Waldemar A., Tshefu, Antoinette, Koso-Thomas, Marion, Siddiqi, Sameen, and Goldenberg, Robert L.

Published
2020
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19. Maternal mortality in six low and lower-middle income countries from 2010 to 2018: risk factors and trends

Author

Bauserman, Melissa, Thorsten, Vanessa R., Nolen, Tracy L., Patterson, Jackie, Lokangaka, Adrien, Tshefu, Antoinette, Patel, Archana B., Hibberd, Patricia L., Garces, Ana L., Figueroa, Lester, Krebs, Nancy F., Esamai, Fabian, Nyongesa, Paul, Liechty, Edward A., Carlo, Waldemar A., Chomba, Elwyn, Goudar, Shivaprasad S., Kavi, Avinash, Derman, Richard J., Saleem, Sarah, Jessani, Saleem, Billah, Sk Masum, Koso-Thomas, Marion, McClure, Elizabeth M., Goldenberg, Robert L., and Bose, Carl

Published
2020
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20. Development of the Global Network for Women’s and Children’s Health Research’s socioeconomic status index for use in the network’s sites in low and lower middle-income countries

Author

Patel, Archana B., Bann, Carla M., Garces, Ana L., Krebs, Nancy F., Lokangaka, Adrien, Tshefu, Antoinette, Bose, Carl L., Saleem, Sarah, Goldenberg, Robert L., Goudar, Shivaprasad S., Derman, Richard J., Chomba, Elwyn, Carlo, Waldemar A., Esamai, Fabian, Liechty, Edward A., Koso-Thomas, Marion, McClure, Elizabeth M., and Hibberd, Patricia L.

Published
2020
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21. Rates and risk factors for preterm birth and low birthweight in the global network sites in six low- and low middle-income countries

Author

Pusdekar, Yamini V., Patel, Archana B., Kurhe, Kunal G., Bhargav, Savita R., Thorsten, Vanessa, Garces, Ana, Goldenberg, Robert L., Goudar, Shivaprasad S., Saleem, Sarah, Esamai, Fabian, Chomba, Elwyn, Bauserman, Melissa, Bose, Carl L., Liechty, Edward A., Krebs, Nancy F., Derman, Richard J., Carlo, Waldemar A., Koso-Thomas, Marion, Nolen, Tracy L., McClure, Elizabeth M., and Hibberd, Patricia L.

Published
2020
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22. The relationship between birth intervals and adverse maternal and neonatal outcomes in six low and lower-middle income countries

Author

Bauserman, Melissa, Nowak, Kayla, Nolen, Tracy L., Patterson, Jackie, Lokangaka, Adrien, Tshefu, Antoinette, Patel, Archana B., Hibberd, Patricia L., Garces, Ana L., Figueroa, Lester, Krebs, Nancy F., Esamai, Fabian, Liechty, Edward A., Carlo, Waldemar A., Chomba, Elwyn, Mwenechanya, Musaku, Goudar, Shivaprasad S., Ramadurg, Umesh, Derman, Richard J., Saleem, Sarah, Jessani, Saleem, Koso-Thomas, Marion, McClure, Elizabeth M., Goldenberg, Robert L., and Bose, Carl

Published
2020
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23. Stillbirth 2010–2018: a prospective, population-based, multi-country study from the Global Network

Author

McClure, Elizabeth M., Saleem, Sarah, Goudar, Shivaprasad S., Garces, Ana, Whitworth, Ryan, Esamai, Fabian, Patel, Archana B., Tikmani, Shiyam Sunder, Mwenechanya, Musaku, Chomba, Elwyn, Lokangaka, Adrien, Bose, Carl L., Bucher, Sherri, Liechty, Edward A., Krebs, Nancy F., Yogesh Kumar, S., Derman, Richard J., Hibberd, Patricia L., Carlo, Waldemar A., Moore, Janet L., Nolen, Tracy L., Koso-Thomas, Marion, and Goldenberg, Robert L.

Published
2020
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24. Neonatal deaths in infants born weighing ≥ 2500 g in low and middle-income countries

Author

Saleem, Sarah, Naqvi, Farnaz, McClure, Elizabeth M., Nowak, Kayla J., Tikmani, Shiyam Sunder, Garces, Ana L., Hibberd, Patricia L., Moore, Janet L., Nolen, Tracy L., Goudar, Shivaprasad S., Kumar, Yogesh, Esamai, Fabian, Marete, Irene, Patel, Archana B., Chomba, Elwyn, Mwenechanya, Musaku, Bose, Carl L., Liechty, Edward A., Krebs, Nancy F., Derman, Richard J., Carlo, Waldemar A., Tshefu, Antoinette, Koso-Thomas, Marion, Siddiqi, Sameen, and Goldenberg, Robert L.

Published
2020
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25. The Global Network Maternal Newborn Health Registry: a multi-country, community-based registry of pregnancy outcomes

Author

McClure, Elizabeth M., Garces, Ana L., Hibberd, Patricia L., Moore, Janet L., Goudar, Shivaprasad S., Saleem, Sarah, Esamai, Fabian, Patel, Archana, Chomba, Elwyn, Lokangaka, Adrien, Tshefu, Antoinette, Haque, Rashidul, Bose, Carl L., Liechty, Edward A., Krebs, Nancy F., Derman, Richard J., Carlo, Waldemar A., Petri, William, Koso-Thomas, Marion, and Goldenberg, Robert L.

Published
2020
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26. Oligohydramnios: a prospective study of fetal, neonatal and maternal outcomes in low-middle income countries

Author

Figueroa, Lester, McClure, Elizabeth M., Swanson, Jonathan, Nathan, Robert, Garces, Ana L., Moore, Janet L., Krebs, Nancy F., Hambidge, K. Michael, Bauserman, Melissa, Lokangaka, Adrien, Tshefu, Antoinette, Mirza, Waseem, Saleem, Sarah, Naqvi, Farnaz, Carlo, Waldemar A., Chomba, Elwyn, Liechty, Edward A., Esamai, Fabian, Swanson, David, Bose, Carl L., and Goldenberg, Robert L.

Published
2020
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28. Polyhydramnios among women in a cluster-randomized trial of ultrasound during prenatal care within five low and low-middle income countries: a secondary analysis of the first look study

Author

Bauserman, Melissa, Nathan, Robert, Lokangaka, Adrien, McClure, Elizabeth M., Moore, Janet, Ishoso, Daniel, Tshefu, Antoinette, Figueroa, Lester, Garces, Ana, Harrison, Margo S., Wallace, Dennis, Saleem, Sarah, Mirza, Waseem, Krebs, Nancy, Hambidge, Michael, Carlo, Waldemar, Chomba, Elwyn, Miodovnik, Menachem, Koso-Thomas, Marion, Liechty, Edward A., Esamai, Fabian, Swanson, Jonathan, Swanson, David, Goldenberg, Robert L., and Bose, Carl

Published
2019
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29. Delayed and Interrupted Ventilation with Excess Suctioning after Helping Babies Breathe with Congolese Birth Attendants

Author

Patterson, Jackie K., primary, Ishoso, Daniel, additional, Eilevstjønn, Joar, additional, Bauserman, Melissa, additional, Haug, Ingunn, additional, Iyer, Pooja, additional, Kamath-Rayne, Beena D., additional, Lokangaka, Adrien, additional, Lowman, Casey, additional, Mafuta, Eric, additional, Myklebust, Helge, additional, Nolen, Tracy, additional, Patterson, Janna, additional, Tshefu, Antoinette, additional, Bose, Carl, additional, and Berkelhamer, Sara, additional

Published
2023
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30. Theory-Driven Process Evaluation of a Complementary Feeding Trial in Four Countries

Author

Newman, Jamie E., Garces, Ana, Mazariegos, Manolo, Hambidge, K. Michael, Manasyan, Albert, Tshefu, Antoinette, Lokangaka, Adrien, Sami, Neelofar, Carlo, Waldemar A., Bose, Carl L., Pasha, Omrana, Goco, Norman, Chomba, Elwyn, Goldenberg, Robert L., Wright, Linda L., Koso-Thomas, Marion, and Krebs, Nancy F.

Abstract

We conducted a theory-driven process evaluation of a cluster randomized controlled trial comparing two types of complementary feeding (meat versus fortified cereal) on infant growth in Guatemala, Pakistan, Zambia and the Democratic Republic of Congo. We examined process evaluation indicators for the entire study cohort (N = 1236) using chi-square tests to examine differences between treatment groups. We administered exit interviews to 219 caregivers and 45 intervention staff to explore why caregivers may or may not have performed suggested infant feeding behaviors. Multivariate regression analysis was used to determine the relationship between caregiver scores and infant linear growth velocity. As message recall increased, irrespective of treatment group, linear growth velocity increased when controlling for other factors (P < 0.05), emphasizing the importance of study messages. Our detailed process evaluation revealed few differences between treatment groups, giving us confidence that the main trial's lack of effect to reverse the progression of stunting cannot be explained by differences between groups or inconsistencies in protocol implementation. These findings add to an emerging body of literature suggesting limited impact on stunting of interventions initiated during the period of complementary feeding in impoverished environments. The early onset and steady progression support the provision of earlier and comprehensive interventions.

Published
2014
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31. Factors influencing referrals for ultrasound-diagnosed complications during prenatal care in five low and middle income countries

Author

Franklin, Holly L., Mirza, Waseem, Swanson, David L., Newman, Jamie E., Goldenberg, Robert L., Muyodi, David, Figueroa, Lester, Nathan, Robert O., Swanson, Jonathan O., Goldsmith, Nicole, Kanaiza, Nancy, Naqvi, Farnaz, Pineda, Irma Sayury, López-Gomez, Walter, Hamsumonde, Dorothy, Bolamba, Victor Lokomba, Fogleman, Elizabeth V., Saleem, Sarah, Esamai, Fabian, Liechty, Edward A., Garces, Ana L., Krebs, Nancy F., Michael Hambidge, K., Chomba, Elwyn, Mwenechanya, Musaku, Carlo, Waldemar A., Tshefu, Antoinette, Lokangaka, Adrien, Bose, Carl L., Koso-Thomas, Marion, Miodovnik, Menachem, and McClure, Elizabeth M.

Published
2018
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33. Perceptions and experiences of Congolese midwives implementing a low-cost battery-operated heart rate meter during newborn resuscitation

Author

Thornton, Madeline, primary, Ishoso, Daniel, additional, Lokangaka, Adrien, additional, Berkelhamer, Sara, additional, Bauserman, Melissa, additional, Eilevstjønn, Joar, additional, Iyer, Pooja, additional, Kamath-Rayne, Beena D., additional, Mafuta, Eric, additional, Myklebust, Helge, additional, Patterson, Janna, additional, Tshefu, Antoinette, additional, Bose, Carl, additional, and Patterson, Jackie K., additional

Published
2022
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35. Simplified antibiotic regimens for young infants with possible serious bacterial infection when the referral is not feasible in the Democratic Republic of the Congo

Author

Lokangaka, Adrien, Ishoso, Daniel Katuashi, Tshefu, Antoinette Kitoto, Kalonji, Michel, Takoy, Paulin, Kokolomami, Jack, Otomba, John, Aboubaker, Samira, Qazi, Shamim Ahmad, Nisar, Yasir Bin, Bahl, Rajiv, Bose, Carl, Coppieters, Yves, Lokangaka, Adrien, Ishoso, Daniel Katuashi, Tshefu, Antoinette Kitoto, Kalonji, Michel, Takoy, Paulin, Kokolomami, Jack, Otomba, John, Aboubaker, Samira, Qazi, Shamim Ahmad, Nisar, Yasir Bin, Bahl, Rajiv, Bose, Carl, and Coppieters, Yves

Abstract

Introduction Neonates with serious bacterial infections should be treated with injectable antibiotics after hospitalization, which may not be feasible in many low resource settings. In 2015, the World Health Organization (WHO) launched a guideline for the management of young infants (0- 59 days old) with possible serious bacterial infection (PSBI) when referral for hospital treatment is not feasible. We evaluated the feasibility of the WHO guideline implementation in the Democratic Republic of the Congo (DRC) to achieve high coverage of PSBI treatment. Methods From April 2016 to March 2017, in a longitudinal, descriptive, mixed methods implementation research study, we implemented WHO PSBI guideline for sick young infants (0-59 dyas of age) in the public health programme setting in five health areas of North and South Ubangi Provinces with an overall population of about 60,000. We conducted policy dialogue with national and sub-national level government planners, decision-makers, academics and other stakeholders. We established a Technical Support Unit to provide implementation support. We built the capacity of health workers and managers and ensured the availability of necessary medicines and commodities. We followed infants with PSBI signs up to 14 days. The research team systematically collected data on adherence to treatment and outcomes. Results We identified 3050 live births and 285 (9.3%) young infants with signs of PSBI in the study area, of whom 256 were treated. Published data have reported 10% PSBI incidence rate in young infants. Therefore, the estimated coverage of treatment was 83.9% (256/305). Another 426 from outside the study catchment area were also identified with PSBI signs by the nurses of a health centre within the study area. Thus, a total of 711 young infants with PSBI were identified, 285 (40%) 7-59 days old infants had fast breathing (pneumonia), 141 (20%) 0-6 days old had fast breathing (severe pneumonia), 233 (33%) had signs of clinical s, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

36. Randomized controlled trial of meat compared with multimicronutrient-fortified cereal in infants and toddlers with high stunting rates in diverse settings

Author

Krebs, Nancy F, Mazariegos, Manolo, Chomba, Elwyn, Sami, Neelofar, Pasha, Omrana, Tshefu, Antoinette, Carlo, Waldemar A, Goldenberg, Robert L, Bose, Carl L, Wright, Linda L, Koso-Thomas, Marion, Goco, Norman, Kindem, Mark, McClure, Elizabeth M, Westcott, Jamie, Garces, Ana, Lokangaka, Adrien, Manasyan, Albert, Imenda, Edna, Hartwell, Tyler D, and Hambidge, K Michael

Published
2012
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37. Simplified antibiotic regimens for young infants with possible serious bacterial infection when the referral is not feasible in the Democratic Republic of the Congo

Author

Lokangaka, Adrien, primary, Ishoso, Daniel, additional, Tshefu, Antoinette, additional, Kalonji, Michel, additional, Takoy, Paulin, additional, Kokolomami, Jack, additional, Otomba, John, additional, Aboubaker, Samira, additional, Qazi, Shamim Ahmad, additional, Nisar, Yasir Bin, additional, Bahl, Rajiv, additional, Bose, Carl, additional, and Coppieters, Yves, additional

Published
2022
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40. Helping Babies Survive Training Programs: Evaluating a Teaching Cascade in Ethiopia

Author

Worku Bogale, Bose Carl, Jones Denise, Weinberg Steven, Patterson Jacquelyn, and Kumera Megerssa

Subjects
Adult, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Future studies, education, Global Health, Midwifery, Training (civil), Dreyfus model of skill acquisition, Education, Education, Nursing, Continuing, Pregnancy, Infant Mortality, medicine, Global health, Training, Humans, Developing Countries, Global Health, Education, Infant, Newborn, Helping Babies Survive, Helping Babies Breathe, Training, Neonatal mortality, business.industry, Infant, Newborn, Infant, General Medicine, Middle Aged, Newborn, Helping Babies Breathe, Family medicine, Helping Babies Survive, Christian ministry, Original Article, Female, Clinical Competence, Curriculum, Ethiopia, business
Abstract

Background: 2.6 million neonates die annually; the vast majority of deaths occur in low- and middle-income countries (LMICs). The Helping Babies Survive (HBS) programs are commonly used in LMICs to reduce neonatal mortality through education. They are typically disseminated using a train-the-trainer cascade. However, there is little published literature on the extent and cost of dissemination. In 2015, the Ethiopian Ministry of Health and partner organizations implemented a countrywide HBS training cascade for midwives in 169 hospitals.Methods: We quantified the extent of HBS dissemination, and characterized barriers that impeded successful hospital-based training by surveying a representative from each of the 169 participant hospitals. This occurred from September 2017 to April 2018. We also assessed the cost of the training cascade. To assess acquisition of knowledge and skill in the training cascade, multiple-choice question examinations (MCQE) and objective structured clinical evaluations (OSCE) were conducted.Results: Hospital-based training occurred in 132 participant hospitals (78%). 1,146 midwives, 69% of those employed by participant hospitals, received hospital-based training. Barriers included lack of preparation of hospital-based educators and limited logistical support. The cascade cost an average of 2,105 USD per facility or 197 USD per trainee. Knowledge improved and skills were adequate for regional workshop attendees based on MCQE and OSCE performance.Conclusion: The train-the-trainer strategy is an effective and affordable strategy for widespread dissemination of the HBS programs in LMICs. Future studies should assess knowledge and skill acquisition following the variety of pragmatic training approaches that may be employed at the facility-level.

Published
2019

43. Implementing the Dubowitz assessment of gestational age in India and Malawi: a cross-sectional study of participants in a training workshop

Author

North, Krysten, primary, Bellad, Roopa M., additional, Bose, Carl, additional, Dhaded, Sangappa M., additional, Goudar, Shivaprasad S., additional, Herekar, Veena, additional, Hoffman, Irving, additional, Mvalo, Tisungane, additional, Phiri, Melda, additional, Saidi, Friday, additional, Vernekar, Sunil S., additional, Vesel, Linda, additional, Lee, Anne C. C., additional, and Semrau, Katherine E. A., additional

Published
2021
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44. Gestational weight gain in 4 low- and middle-income countries and associations with birth outcomes: a secondary analysis of the Women First Trial

Author

Bauserman, Melissa S, primary, Bann, Carla M, additional, Hambidge, K Michael, additional, Garces, Ana L, additional, Figueroa, Lester, additional, Westcott, Jamie L, additional, Patterson, Jackie K, additional, McClure, Elizabeth M, additional, Thorsten, Vanessa R, additional, Aziz, Sumera Ali, additional, Saleem, Sarah, additional, Goldenberg, Robert L, additional, Derman, Richard J, additional, Herekar, Veena, additional, Somannavar, Manjunath, additional, Koso-Thomas, Marion W, additional, Lokangaka, Adrien L, additional, Tshefu, Antoinette K, additional, Krebs, Nancy F, additional, and Bose, Carl L, additional

Published
2021
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45. Additional file 1 of The relationship between birth intervals and adverse maternal and neonatal outcomes in six low and lower-middle income countries

Author

Bauserman, Melissa, Nowak, Kayla, Nolen, Tracy L., Patterson, Jackie, Lokangaka, Adrien, Tshefu, Antoinette, Patel, Archana B., Hibberd, Patricia L., Garces, Ana L., Figueroa, Lester, Krebs, Nancy F., Esamai, Fabian, Liechty, Edward A., Carlo, Waldemar A., Chomba, Elwyn, Musaku Mwenechanya, Shivaprasad S. Goudar, Ramadurg, Umesh, Derman, Richard J., Saleem, Sarah, Jessani, Saleem, Koso-Thomas, Marion, McClure, Elizabeth M., Goldenberg, Robert L., and Bose, Carl

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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46. Helping Babies Survive Programs as an Impetus for Quality Improvement.

Author

Ehret, Danielle E Y, Patterson, Jackie K, KC, Ashish, Worku, Bogale, Kamath-Rayne, Beena D, Bose, Carl L, Ehret, Danielle E Y, Patterson, Jackie K, KC, Ashish, Worku, Bogale, Kamath-Rayne, Beena D, and Bose, Carl L

Abstract

Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs targeting the 3 leading causes of neonatal mortality, has been commonly used to educate providers in evidence-based practices in low-resource settings. Quality improvement (QI) can play a pivotal role in translating this education into improved care. Measurement of key process and outcome indicators, derived from the algorithms ("Action Plans") central to these training programs, can assist health care providers in understanding the baseline quality of their care, identifying gaps, and assessing improvement. Helping Babies Survive has been the focus of QI programs in Kenya, Nepal, Honduras, and Ethiopia, with critical lessons learned regarding the challenge of measurement, necessity of facility-based QI mentorship and multidisciplinary teams, and importance of systemic commitment to improvement in promoting a culture of QI. Complementing education with QI strategies to identify and close remaining gaps in newborn care will be essential to achieving the Sustainable Development Goals and Every Newborn Action Plan targets in the coming decade.

Published
2020
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