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152 results on '"Bosch‐Nicolau, Pau"'

1. Adherence and toxicity during the treatment of latent tuberculous infection in a referral center in Spain

Author

Ortiz, Juan David Puyana, Rodriguez, Andrea Carolina Garces, Aznar, Maria Luisa, Pereiro, Juan Espinosa, Sanchez-Montalva, Adrian, Martinez-Camprecios, Joan, Saborit, Nuria, Rodrigo-Pendas, Jose Angel, Salgado, Guadalupe Garcia, Cortes, Claudia Broto, Delcor, Nuria Serre, Oliveira, Ines, Maruri, Begona Trevino, Ciruelo, Diana Pou, Salvador, Fernando, Bosch-Nicolau, Pau, Torrecilla-Martinez, Irene, Zules-Ona, Ricardo, Fernandez, Maria Teresa Tortola, and Molina, Israel

Published
2023

4. Author Correction: Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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5. Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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6. Prevalence of Chagas disease among Latin American immigrants in non-endemic countries: an updated systematic review and meta-analysis

Author

Nepomuceno de Andrade, Gisele, Bosch-Nicolau, Pau, Nascimento, Bruno R., Martins-Melo, Francisco Rogerlândio, Perel, Pablo, Geissbühler, Yvonne, Demacq, Caroline, Quijano, Monica, Mosser, Jonathan F., Cousin, Ewerton, Machado, Ísis Eloah, Rodrigues, Matheus Lucca A.C., Ribeiro, Antonio Luiz P., and Molina, Israel

Published
2024
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7. Imported schistosomiasis in travelers: Experience from a referral tropical medicine unit in Barcelona, Spain

Author

Salvador, Fernando, Bocanegra, Cristina, Treviño, Begoña, Sulleiro, Elena, Sánchez-Montalvá, Adrián, Serre-Delcor, Núria, Bosch-Nicolau, Pau, Aznar, M<ce:sup loc='post">a</ce:sup> Luisa, Goterris, Lidia, Pou, Diana, Espiau, María, Martínez-Campreciós, Joan, Espinosa-Pereiro, Juan, Oliveira, Inés, Zarzuela, Francesc, Martínez-Vallejo, Patricia, and Molina, Israel

Published
2024
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8. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author

Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R

Published
2024
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10. Endomyocardial involvement in asymptomatic Latin American migrants with eosinophilia related to helminth infection: A pilot study.

Author

Sempere, Abiu, Salvador, Fernando, Milà, Laia, Casas, Guillem, Durà-Miralles, Xavier, Sulleiro, Elena, Vila-Olives, Rosa, Bosch-Nicolau, Pau, Aznar, Maria Luisa, Espinosa-Pereiro, Juan, Treviño, Begoña, Sánchez-Montalvá, Adrián, Serre-Delcor, Núria, Oliveira-Souto, Inés, Pou, Diana, Rodríguez-Palomares, José, and Molina, Israel

Subjects
LATIN Americans, HELMINTHIASIS, MICROBIOLOGICAL techniques, HYPEREOSINOPHILIC syndrome, LEFT heart atrium
Abstract

Background: Hypereosinophilic syndrome can produce cardiac involvement and endomyocardial fibrosis, which have a poor prognosis. However, there is limited information regarding cardiac involvement among migrants from Latin America with eosinophilia related to helminthiasis. Methods: We conducted a pilot observational study where an echocardiography was performed on migrants from Latin America with both eosinophilia (>450 cells/μL) and a diagnosis of helminth infection, and on migrants from Latin America without eosinophilia or helminth infection. Microbiological techniques included a stool microscopic examination using the Ritchie's formalin-ether technique, and a specific serology to detect Strongyloides stercoralis antibodies. Results: 37 participants were included, 20 with eosinophilia and 17 without eosinophilia. Twenty (54.1%) were men with a mean age of 41.3 (SD 14.3) years. Helminthic infections diagnosed in the group with eosinophilia were: 17 cases of S. stercoralis infection, 1 case of hookworm infection, and 2 cases of S. stercoralis and hookworm coinfection. Among participants with eosinophilia, echocardiographic findings revealed a greater right ventricle thickness (p = 0.001) and left atrial area and volume index (p = 0.003 and p = 0.004, respectively), while showing a lower left atrial strain (p = 0.006) and E-wave deceleration time (p = 0.008). An increase was shown in both posterior and anterior mitral leaflet thickness (p = 0.0014 and p = 0.004, respectively) when compared with participants without eosinophilia. Conclusions: Migrants from Latin America with eosinophilia related to helminthic infections might present incipient echocardiographic alterations suggestive of early diastolic dysfunction, that could be related to eosinophilia-induced changes in the endomyocardium. Author summary: A recent study in migrants from Sub-Saharan Africa with eosinophilia related to helminth infection describes initial findings on cardiac ultrasound in the form of thickening of the posterior leaflet of the mitral valve, but with no clinical manifestations, representing the early stage of the endomyocardial fibrosis process. The aim of the present study is to evaluate the relationship between eosinophilia secondary to helminth infection and cardiac involvement in Latin American patients. In our cohort, eosinophilia in patients was mainly due to Strongyloides stercoralis infection. Among patients with eosinophilia, echocardiographic findings revealed a greater right ventricle thickness and left atrial area and volume index, while showing a lower left atrial strain and E-wave deceleration time when compared with patients without eosinophilia. These alterations are suggestive of early diastolic dysfunction that could be related to eosinophilia-induced changes in the endomyocardium. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Usefulness of Xpert MTB/RIF and Xpert Ultra to Categorize Risk of Tuberculosis Transmission to Household Contacts.

Author

Mol, Alexander, Sánchez-Montalvá, Adrián, Espinosa-Pereiro, Juan, Aznar, Maria Luisa, Salvador, Fernando, Bosch-Nicolau, Pau, Souza-Galvão, Maria-Luiza de, Jiménez, María Ángeles, Rodrigo-Pendás, José Ángel, Millet, Joan-Pau, Saborit, Nuria, Broto, Claudia, Molina, Israel, and Tórtola, Teresa

Subjects
LATENT tuberculosis, TUBERCULOSIS, CONTACT tracing, UNIVERSITY hospitals, REGRESSION analysis
Abstract

Background People with pulmonary tuberculosis (PTB) are contagious, particularly to their household contacts. Their infectivity has been associated with the bacterial load in sputum samples. This study investigated if the bacterial load in sputum samples as quantified by Xpert MTB/RIF and Xpert Ultra is correlated with the extent that latent tuberculosis infection (LTBI) occurred in household contacts of people with PTB. Methods A retrospective study was performed including people with PTB presenting at Vall d'Hebron University Hospital, Barcelona, between 2011 and 2021. Their infection ratio, representing the proportion of household members found with LTBI in contact tracing investigation, was compared with the quantitative results of Xpert MTB/RIF and Xpert Ultra using ordinal regression analysis. Results A total of 107 people with PTB were included. Among their 398 household contacts, 126 (31.7%) cases of LTBI and 14 cases with active TB disease (3.5%) were reported. Higher bacterial load in Xpert MTB/RIF and Xpert Ultra baseline sputum was significantly associated with increased infection ratios, providing better estimates than conventional acid-fast bacilli (AFB) smear grading. Conclusions Xpert MTB/RIF and Xpert Ultra could serve as an alternative to AFB sputum-smear grading in determining contact tracing priorities. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain

Author

Puyana Ortiz, Juan David, primary, Garcés Rodríguez, Andrea Carolina Garcés, additional, Aznar, María Luisa, additional, Espinosa Pereiro, Juan, additional, Sánchez-Montalvá, Adrián, additional, Martínez-Campreciós, Joan, additional, Saborit, Nuria, additional, Rodrigo-Pendás, José Ángel, additional, García Salgado, Guadalupe, additional, Broto Cortes, Claudia Broto, additional, Delcor, Nuria Serre, additional, Oliveira, Inés, additional, Treviño Maruri, Begoña Treviño, additional, Ciruelo, Diana Pou, additional, Salvador, Fernando, additional, Bosch-Nicolau, Pau, additional, Torrecilla-Martínez, Irene, additional, Zules-Oña, Ricardo, additional, Tórtola Fernández, María Teresa Tórtola, additional, and Molina, Israel, additional

Published
2023
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15. Corrigendum to “Epidemiological and clinical profile of adult patients with diarrhoea after international travel attended in an International Health referral center” [Trav Med Infect Dis 45 (2022) 102216]

Author

España-Cueto, Sergio, primary, Salvador, Fernando, additional, Oliveira, Inés, additional, Goterris, Lidia, additional, Treviño, Begoña, additional, Sánchez-Montalvá, Adrián, additional, Serre-Delcor, Núria, additional, Sulleiro, Elena, additional, Rodríguez, Virginia, additional, Aznar, María Luisa, additional, Bosch-Nicolau, Pau, additional, Espinosa-Pereiro, Juan, additional, Pou, Diana, additional, and Molina, Israel, additional

Published
2023
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16. Unexpected Loa loa Finding in an Asymptomatic Patient From The Gambia: A Case Report

Author

Treviño, Begoña, primary, Zarzuela, Francesc, additional, Oliveira-Souto, Inés, additional, Maturana, Carles Rubio, additional, Serre-Delcor, Núria, additional, Aznar, Maria L, additional, Pou, Diana, additional, Goterris, Lidia, additional, Salvador, Fernando, additional, Bosch-Nicolau, Pau, additional, Rubio, José M, additional, Ruiz, Edurne, additional, Molina, Israel, additional, and Sulleiro, Elena, additional

Published
2023
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17. Serial lung ultrasound in monitoring viral pneumonia: the lesson learned from COVID-19

Author

Clofent, David, primary, Culebras, Mario, additional, Felipe-Montiel, Almudena, additional, Arjona-Peris, Marta, additional, Granados, Galo, additional, Sáez, María, additional, Pilia, Florencia, additional, Ferreiro, Antía, additional, Álvarez, Antonio, additional, Loor, Karina, additional, Bosch-Nicolau, Pau, additional, and Polverino, Eva, additional

Published
2023
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18. A difficult to treat Leishmania infantum relapse after allogeneic stem cell transplantation

Author

Arts, R.J.W., Ector, G.I.C.G., Bosch-Nicolau, Pau, Molina, Isreal, McCall, M.B.B., Velden, W.J.F.M. van der, Laarhoven, A. van, Mast, Q. de, Dorp, S. van, Arts, R.J.W., Ector, G.I.C.G., Bosch-Nicolau, Pau, Molina, Isreal, McCall, M.B.B., Velden, W.J.F.M. van der, Laarhoven, A. van, Mast, Q. de, and Dorp, S. van

Abstract

Contains fulltext : 292665.pdf (Publisher’s version ) (Open Access)

Published
2023

19. Imported Strongyloides stercoralis infection and diabetes mellitus and other metabolic diseases: Is there any association?

Author

Salvador, Fernando, primary, Galvis, Daniel, additional, Treviño, Begoña, additional, Sulleiro, Elena, additional, Sánchez‐Montalvá, Adrián, additional, Serre‐Delcor, Núria, additional, Goterris, Lidia, additional, Aznar, Mª Luisa, additional, Bosch‐Nicolau, Pau, additional, Oliveira, Inés, additional, Espinosa‐Pereiro, Juan, additional, Pou, Diana, additional, and Molina, Israel, additional

Published
2023
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21. Opportunistic Community Screening of Chronic Chagas Disease Using a Rapid Diagnosis Test in Pharmacies in Barcelona (Catalonia, Spain): Study Protocol and Pilot Phase Results

Author

Silgado, Aroa, primary, Bosch-Nicolau, Pau, additional, Sánchez-Montalvá, Adrián, additional, Cervià, Ariadna, additional, Gomez-i-Prat, Jordi, additional, Bagaria, Guillermo, additional, Rodriguez, Cristina, additional, Goterris, Lidia, additional, Serre-Delcor, Núria, additional, Oliveira-Souto, Inés, additional, Salvador, Fernando, additional, Molina, Israel, additional, and Sulleiro, Elena, additional

Published
2022
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22. Community-acquired pneumonia in hospitalised patients: changes in aetiology, clinical presentation, and severity outcomes in a 10-year period

Author

Sellarès-Nadal, Júlia, primary, Burgos, Joaquín, additional, Martín-Gómez, María Teresa, additional, Antón, Andrés, additional, Sordé, Roger, additional, Romero-Herrero, Daniel, additional, Bosch-Nicolau, Pau, additional, Falcó-Roget, Anna, additional, Kirkegaard, Cristina, additional, Rodríguez-Pardo, Dolors, additional, Len, Oscar, additional, and Falcó, Vicenç, additional

Published
2022
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23. Efficacy and Safety of Tinzaparin in Prophylactic, Intermediate and Therapeutic Doses in Non-Critically Ill Patients Hospitalized with COVID-19: The PROTHROMCOVID Randomized Controlled Trial

Author

Muñoz-Rivas, Nuria, primary, Aibar, Jesús, additional, Gabara-Xancó, Cristina, additional, Trueba-Vicente, Ángela, additional, Urbelz-Pérez, Ana, additional, Gómez-Del Olmo, Vicente, additional, Demelo-Rodríguez, Pablo, additional, Rivera-Gallego, Alberto, additional, Bosch-Nicolau, Pau, additional, Perez-Pinar, Montserrat, additional, Rios-Prego, Mónica, additional, Madridano-Cobo, Olga, additional, Ramos-Alonso, Laura, additional, Alonso-Carrillo, Jesús, additional, Francisco-Albelsa, Iria, additional, Martí-Saez, Edelmira, additional, Maestre-Peiró, Ana, additional, Méndez-Bailón, Manuel, additional, Hernández-Rivas, José Ángel, additional, and Torres-Macho, Juan, additional

Published
2022
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25. Case Report: Leishmaniasis in a 33-Year-Old Man with Multiple Sclerosis

Author

Guerra-Amor, Alvaro, primary, Lopez-Gonzalez, Ane, additional, Bosch-Nicolau, Pau, additional, Rodriguez-Acevedo, Breogan, additional, Zabalza, Ana, additional, Sulleiro, Elena, additional, Espinosa-Pereiro, Juan, additional, Aznar, Maria Luisa, additional, Salvador, Fernando, additional, Sánchez-Montalvá, Adrián, additional, and Molina, Israel, additional

Published
2022
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26. Association Between Trypanosoma cruzi DNA in Peripheral Blood and Chronic Chagasic Cardiomyopathy : A Systematic Review

Author

Bosch-Nicolau, Pau, Espinosa-Pereiro, Juan, Salvador, Fernando, Sánchez-Montalvá, Adrián, Molina, Israel, Bosch-Nicolau, Pau, Espinosa-Pereiro, Juan, Salvador, Fernando, Sánchez-Montalvá, Adrián, and Molina, Israel

Abstract

Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020216072, identifier: CRD42020216072., Chronic chagasic cardiomyopathy (CCC) is the most important complication of patients with Chagas disease (CD). The role of persistent detection of DNA in peripheral blood and its association to CCC is unknown. We performed a systematic review up to July 2021, including studies that reported ratios of CCC and PCR positivity among non-treated adult patients. We identified 749 records and selected 12 for inclusion corresponding to 1,686 patients. Eight studies were performed in endemic countries and 4 in non-endemic countries. Only two studies showed an association between CCC and Trypanosoma cruzi parasitemia by means of PCR detection. Six studies reported greater positive PCR ratios among patients with CCC than in the patients with indeterminate chagas disease (ICD) with no statistical significance. A significant risk of bias has been detected among most of the studies. Therefore, while we performed a meta-analysis, wide inter-study heterogeneity impeded its interpretation. Conclusions: With the available information, we could not establish a correlation between PCR-detectable parasitemia and CCC.

Published
2022

27. Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial

Author

Molina-Morant, D., Fernández, M. L., Bosch-Nicolau, Pau, Sulleiro, Elena, Bangher, M., Salvador, F., Sanchez-Montalva, A., Ribeiro, A. L. P., de Paula, A. M. B., Eloi, S., Correa-Oliveira, Rodrigo, Villar, J. C., Sosa-Estani, S., Molina Romero, Israel, and Universitat Autònoma de Barcelona

Subjects
Male, Chagas disease, Medicine (miscellaneous), Aftercare, Parasite Load, Study Protocol, 0302 clinical medicine, purl.org/becyt/ford/3.2 [https], Pharmacology (medical), media_common, 0303 health sciences, lcsh:R5-920, Standard treatment, Neglected Diseases, CLINICAL TRIAL, Trypanocidal Agents, THERAPEUTIC, Multicenter study, Clinical trial, Treatment Outcome, Tolerability, Benznidazole, Nitroimidazoles, Female, purl.org/becyt/ford/3 [https], Safety, Therapeutic, lcsh:Medicine (General), Brazil, medicine.drug, Drug, Adult, medicine.medical_specialty, Randomization, BENZNIDAZOLE, media_common.quotation_subject, Trypanosoma cruzi, 030231 tropical medicine, Argentina, Colombia, 03 medical and health sciences, Pharmacokinetics, Double-Blind Method, Internal medicine, medicine, Humans, 030306 microbiology, business.industry, CHAGAS DISEASE, Regimen, Spain, Case-Control Studies, Chronic Disease, MULTICENTER STUDY, business
Abstract

Background: Chagas disease (CD) continues to be a neglected infectious disease with one of the largest burdens globally. Despite the modest cure rates in adult chronic patients and its safety profile, benznidazole (BNZ) is still the drug of choice. Its current recommended dose is based on nonrandomized studies, and efficacy and safety of the optimal dose of BNZ have been scarcely analyzed in clinical trials.Methods/design: MULTIBENZ is a phase II, randomized, noninferiority, double-blind, multicenter international clinical trial. A total of 240 patients with Trypanosoma CD in the chronic phase will be recruited in four different countries (Argentina, Brazil, Colombia, and Spain). Patients will be randomized to receive BNZ 150 mg/day for 60 days, 400 mg/day for 15 days, or 300 mg/day for 60 days (comparator arm). The primary outcome is the efficacy of three different BNZ therapeutic schemes in terms of dose and duration. Efficacy will be assessed according to the proportion of patients with sustained parasitic load suppression in peripheral blood measured by polymerase chain reaction. The secondary outcomes are related to pharmacokinetics and drug tolerability. The follow-up will be 12 months from randomization to end of study participation. Recruitment was started in April 2018.Conclusion: This is a clinical trial conducted for the assessment of different dose schemes of BNZ compared with the standard treatment regimen for the treatment of CD in the chronic phase. MULTIBENZ may help to clarify which is the most adequate BNZ regimen in terms of efficacy and safety, predicated on sustained parasitic load suppression in peripheral blood. Fil: Molina Morant, D.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España Fil: Fernández, M. L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina Fil: Bosch Nicolau, P.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España Fil: Sulleiro, E.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España Fil: Bangher, M.. Instituto de Cardiologia de Corrientes Juana Francisca Cabral.; Argentina Fil: Salvador, F.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España Fil: Sanchez Montalva, A.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España Fil: Ribeiro, A.L.P.. Universidade Federal de Minas Gerais; Brasil Fil: De Paula, A.M.B.. Universidad Federal de Montes Claros; Brasil Fil: Eloi, S.. Universidade Federal de Minas Gerais; Brasil Fil: Oliveira Correa, Ronaldo. Fundación Oswaldo Cruz; Brasil Fil: Villar, J. C.. Instituto de Cardiología; Colombia Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Molina, I.. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España

Published
2020

29. COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

Author

Sempere-González, Abiu, primary, Salvador, Fernando, additional, Monforte, Arnau, additional, Sampol, Júlia, additional, Espinosa-Pereiro, Juan, additional, Miarons, Marta, additional, Bosch-Nicolau, Pau, additional, Guillén-del-Castillo, Alfredo, additional, Aznar, Maria, additional, Campos-Varela, Isabel, additional, Sánchez-Montalvá, Adrián, additional, Leguízamo-Martínez, Lina, additional, Oliveira, Inés, additional, Antón, Andrés, additional, and Almirante, Benito, additional

Published
2021
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31. Treatment of Complex Cutaneous Leishmaniasis with Liposomal Amphotericin B

Author

Ubals, Maria, primary, Bosch-Nicolau, Pau, additional, Sánchez-Montalvá, Adrián, additional, Salvador, Fernando, additional, Aparicio-Español, Gloria, additional, Sulleiro, Elena, additional, Silgado, Aroa, additional, Soriano-Arandes, Antoni, additional, Espiau, Maria, additional, Ferrer, Berta, additional, Pou, Diana, additional, Treviño, Begoña, additional, Molina, Israel, additional, and García-Patos, Vicente, additional

Published
2021
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32. Risk of Trypanosoma cruzi infection among travellers visiting friends and relatives to continental Latin America

Author

Sánchez-Montalvá, Adrián, primary, Salinas, Catalina, additional, Sullerio, Elena, additional, Salvador, Fernando, additional, Bosch-Nicolau, Pau, additional, Crespillo-Andújar, Clara, additional, Trigo, Elena, additional, Roure, Sílvia, additional, Valerio, Lluís, additional, Espinosa-Pereiro, Juan, additional, and Molina, Israel, additional

Published
2021
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33. Risk of Trypanosoma cruzi infection among travellers visiting friends and relatives to continental Latin America

Author

Sánchez-Montalvá, Adrián, Salinas, Catalina, Sullerio, Elena, Salvador, Fernando, Bosch-Nicolau, Pau, Crespillo-Andújar, Clara, Trigo, Elena, Roure, Silvia, Valerio, Lluís, Espinosa-Pereiro, Juan, Molina Romero, Israel, Sánchez-Montalvá, Adrián, Salinas, Catalina, Sullerio, Elena, Salvador, Fernando, Bosch-Nicolau, Pau, Crespillo-Andújar, Clara, Trigo, Elena, Roure, Silvia, Valerio, Lluís, Espinosa-Pereiro, Juan, and Molina Romero, Israel

Abstract

Chagas disease (CD) is regarded as a possible risk for travellers to endemic areas of continental Latin America (LA). The aim of the study is to determine the risk of Trypanosoma cruzi (TC) infection among travellers to CD endemic areas and to identify risk factors for acquiring TC infection. We designed a multicenter cross-sectional study among travellers in Spain (Badalona, Barcelona and Madrid). All available adults with laboratory confirmed proof of absence of TC infection from January 2012 to December 2015 were contacted. Participants referring a trip to LA after the negative TC screening were offered to participate. We performed a standardized questionnaire of travel related factors and measurement of TC antibodies in serum. A total of 971 participants with baseline negative TC serology were selected from the microbiology records. After excluding participants not meeting inclusion criteria, eighty participants were selected. Sixty three (78.8%) were female, and the median age was 38 (IQR 34-47) years. The reason to travel was visiting friends and relatives in 98.8% of the participants. The median duration of travel was 40 (IQR 30-60) days, with 4911 participants-day of exposure. Seventy seven cases (96.25%) participants had two negative TC serology tests after the travel, two cases (2.5%) had discordant serology results (considered false positive results) and one case was infected before travelling to LA. According to our data, the upper limit of the 95% confidence interval of the incidence rate of TC acquisition in travellers is 0.8 per 1000 participant-days. Among 79 non-CD travellers to TC endemic areas, we found no cases of newly acquired TC infection. The incidence rate of TC acquisition in travellers to endemic countries is less than or equal to 0.8 per 1000 traveller-days. Chagas disease is caused by the protozoan parasite T. cruzi. It is endemic in certain areas of continental Latin America. Few cases of T. cruzi infection have been described in travel

Published
2021

34. Blastocystis sp. Carriage and Irritable Bowel Syndrome : Is the Association Already Established?

Author

Salvador, Fernando, Lobo, Beatriz, Goterris, Lidia, Alonso Cotoner, Carmen, Santos, Javier, Sulleiro, Elena, Bailo, Begoña, Carmena, David, Sánchez-Montalvá, Adrián, Bosch-Nicolau, Pau, Espinosa-Pereiro, Juan, Fuentes, Isabel, Molina, Israel, Salvador, Fernando, Lobo, Beatriz, Goterris, Lidia, Alonso Cotoner, Carmen, Santos, Javier, Sulleiro, Elena, Bailo, Begoña, Carmena, David, Sánchez-Montalvá, Adrián, Bosch-Nicolau, Pau, Espinosa-Pereiro, Juan, Fuentes, Isabel, and Molina, Israel

Abstract

The intestinal protist Blastocystis sp. is one of the most common intestinal parasites observed in humans, and has a worldwide distribution, being more prevalent in developing countries. Although this parasite has been described decades ago, the pathogenic potential it is still not understood completely. It has been suggested that Blastocystis sp. could be related with irritable bowel syndrome, a functional gastrointestinal disorder characterized by abdominal pain, discomfort with defecation, and changes in the frequency or form of stool. In our study, we compare a group of patients with irritable bowel syndrome with a group of healthy volunteers; no differences regarding the occurrence of Blastocystis sp. detection was found between both groups. Background: The aim of the present study is to describe the occurrence of Blastocystis sp. detection among asymptomatic subjects and patients with irritable bowel syndrome in order to evaluate the potential association between irritable bowel syndrome and the parasitic infection. Methods: Cross-sectional study where adult patients with irritable bowel syndrome diagnosed according to Rome IV criteria were included. A control group was formed by asymptomatic subjects older than 18 years. Exclusion criteria were: immunosuppressive condition or having received any drug with demonstrated activity against Blastocystis sp. within the last 6 months before study inclusion. Epidemiological and clinical information was collected from all included participants. Two stool samples were obtained from all participants: one sample for microscopic examination and one sample for Blastocystis sp. PCR detection. Blastocystis sp. infection was defined by the positivity of any of the diagnostic techniques. Results: Seventy-two participants were included (36 asymptomatic subjects and 36 patients with irritable bowel syndrome). Thirty-five (48.6%) were men, and median age of participants was 34 (IQR 29-49) years. The overall rate of Blastocystis sp

Published
2021

35. GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.

Author

Casares-Marfil, Desiré, Kerick, Martin, Andrés-León, Eduardo, Bosch-Nicolau, Pau, Molina, Israel, Martin, Javier, Acosta-Herrera, Marialbert, Casares-Marfil, Desiré, Kerick, Martin, Andrés-León, Eduardo, Bosch-Nicolau, Pau, Molina, Israel, Martin, Javier, and Acosta-Herrera, Marialbert

Abstract

A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzing the correlation among single nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) levels as cis methylation quantitative trait loci (cis-mQTL) within this region. A total of 2,611 SNPs were tested against 2,647 DNAm sites, in a subset of 37 chronic Chagas cardiomyopathy patients and 20 asymptomatic individuals from the GWAS. We identified 6,958 significant cis-mQTLs (False Discovery Rate [FDR]<0.05) at 1 Mb each side of the GWAS leading variant, where six of them potentially modulate the expression of the SAC3D1 gene, the reported gene in the previous GWAS. In addition, a total of 268 cis-mQTLs showed differential methylation between chronic Chagas cardiomyopathy patients and asymptomatic individuals. The most significant cis-mQTLs mapped in the gene bodies of POLA2 (FDR = 1.04x10-11), PLAAT3 (FDR = 7.22x10-03), and CCDC88B (FDR = 1.89x10-02) that have been associated with cardiovascular and hematological traits in previous studies. One of the most relevant interactions correlated with hypermethylation of CCDC88B. This gene is involved in the inflammatory response, and its methylation and expression levels have been previously reported in Chagas cardiomyopathy. Our findings support the functional relevance of the previously associated genomic region, highlighting the regulation of novel genes that could play a role in the chronic cardiac form of the disease.

Published
2021

36. Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study.

Author

Sánchez-Montalvá, Adrián, Álvarez-Sierra, Daniel, Martínez-Gallo, Mónica, Perurena-Prieto, Janire, Arrese-Muñoz, Iria, Ruiz-Rodríguez, Juan Carlos, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Martínez-Gómez, Xavier, Antón, Andrés, Martínez-Valle, Ferran, Riveiro-Barciela, Mar, Blanco-Grau, Albert, Rodríguez-Frias, Francisco, Castellano-Escuder, Pol, Poyatos-Canton, Elisabet, Bas-Minguet, Jordi, Martínez-Cáceres, Eva, Sánchez-Pla, Alex, and Zurera-Egea, Coral

Subjects
PATHOLOGICAL laboratories, COVID-19 testing, COHORT analysis, NEUTROPHIL lymphocyte ratio, ACUTE phase proteins
Abstract

Background: Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited. Objectives: To measure the predictive performance of currently used clinical laboratory tests alone or combined with clinical variables and explore the predictive power of immunological tests adequate for clinical laboratories. Methods: Data from 2,600 COVID-19 patients of the first wave of the pandemic in the Barcelona area (exploratory cohort of 1,579, validation cohorts of 598 and 423 patients) including clinical parameters and laboratory tests were retrospectively collected. 28-day survival and maximal severity were the main outcomes considered in the multiparametric classical and machine learning statistical analysis. A pilot study was conducted in two subgroups (n=74 and n=41) measuring 17 cytokines and 27 lymphocyte phenotypes respectively. Findings: 1) Despite a strong association of clinical and laboratory variables with the outcomes in classical pairwise analysis, the contribution of laboratory tests to the combined prediction power was limited by redundancy. Laboratory variables reflected only two types of processes: inflammation and organ damage but none reflected the immune response, one major determinant of prognosis. 2) Eight of the thirty variables: age, comorbidity index, oxygen saturation to fraction of inspired oxygen ratio, neutrophil-lymphocyte ratio, C-reactive protein, aspartate aminotransferase/alanine aminotransferase ratio, fibrinogen, and glomerular filtration rate captured most of the combined statistical predictive power. 3) The interpretation of clinical and laboratory variables was moderately improved by grouping them in two categories i.e., inflammation related biomarkers and organ damage related biomarkers; Age and organ damage-related biomarker tests were the best predictors of survival, and inflammatory-related ones were the best predictors of severity. 4) The pilot study identified immunological tests (CXCL10, IL-6, IL-1RA and CCL2), that performed better than most currently used laboratory tests. Conclusions: Laboratory tests for clinical management of COVID 19 patients are valuable but limited predictors due to redundancy; this limitation could be overcome by adding immunological tests with independent predictive power. Understanding the limitations of tests in use would improve their interpretation and simplify clinical management but a systematic search for better immunological biomarkers is urgent and feasible. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Blastocystis sp. Carriage and Irritable Bowel Syndrome: Is the Association Already Established?

Author

Salvador, Fernando, primary, Lobo, Beatriz, additional, Goterris, Lidia, additional, Alonso-Cotoner, Carmen, additional, Santos, Javier, additional, Sulleiro, Elena, additional, Bailo, Begoña, additional, Carmena, David, additional, Sánchez-Montalvá, Adrián, additional, Bosch-Nicolau, Pau, additional, Espinosa-Pereiro, Juan, additional, Fuentes, Isabel, additional, and Molina, Israel, additional

Published
2021
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39. Early outcomes of tocilizumab in adults hospitalized with severe COVID19. An initial report from the Vall dHebron COVID19 prospective cohort study

Author

Sanchez-Montalva, Adrian, Selares-Nadal, Julia, Espinosa-Pereiro, Juan, Fernandez-Hidalgo, Nuria, Perez-Hoyos, Santiago, Salvador, Fernando, Dura-Miralles, Xavier, Miarons, Marta, Anton, Andres, Eremiev, Simeon, Sempere-Gonzalez, Abiu, Bosch-Nicolau, Pau, Monforte-Pallares, Arnau, Augustin, Salvador, Sampol, Julia, Guillen-del-Castillo, Alfredo, and Almirante, Benito

Abstract

Background: Modulation of the immune system to prevent lung injury is being widely used against the new coronavirus disease (COVID19) despite the scarcity of evidence. Methods: We report preliminary results from the Vall dHebron prospective cohort study at Vall dHebron University Hospital, in Barcelona (Spain), including all consecutive patients who had a confirmed infection with the severe acute respiratory syndrome coronavirus2 (SARSCoV2) and who were treated with tocilizumab until March 25th. The primary endpoint was mortality at 7 days after tocilizumab administration. Secondary endpoints were admission to the intensive care unit, development of ARDS and respiratory insufficiency among others. Results: 82 patients with COVID19 received at least one dose of tocilizumab. The mean (SD) age was 59.1 (19.8) years, 63% were male, 22% were of non Spanish ancestry, and the median (IQR) ageadjusted Charlson index at baseline was 3 (1 to 4) points. Respiratory failure and ARDS developed in 62 (75.6%) and 45 (54.9%) patients, respectively. Median time from symptom onset to ARDS development was 8 (5 to 11) days. The median time from symptom onset to the first dose of tocilizumab was 9 (7 to 11) days. Mortality at 7 days was 26.8%. Hazard ratio for mortality was 3.3; 95% CI, 1.3 to 8.5 (age adjusted hazard ratio for mortality 2.1; 95% CI, 0.8 to 5.8) if tocilizumab was administered after the onset of ARDS. Conclusion: Time from lung injury onset to tocilizumab administration may be critical to patient recovery. Our preliminary data could inform bedside decisions until more data from clinical trials becomes available.

Published
2020
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40. Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network

Author

Herrador, Zaida, Perez-Molina, Jose A., Henriquez Camacho, Cesar Augusto, Rodriguez-Guardado, Azucena, Bosch-Nicolau, Pau, Calabuig, Eva, Dominguez-Castellano, Angel, Asuncion Perez-Jacoiste, Maria, Ladron de Guevara, M. Concepcion, Mena, Ana, Manuel Ruiz-Giardin, Jose, Torrus, Diego, Wikman-Jorgensen, Philip, Benito, Agustin, Lopez-Velez, Rogelio, Aguilera, Paloma, Martinez Serrano, Maria, Garcia Rodriguez, Magdalena, Diaz Menendez, Marta, Meije, Yolanda, Martinez-Montauti, Joaquim, Sanz, Xavier, Pacheco Tenza, Isabel, Gonzalez Cuello, Inmaculada, Martinez Lopez, Belen, Llenas-Garcia, Jara, Masia, Mar, Padilla, Sergio, Romero, Monica, Ramos Rincon, Jose Manuel, Suarez, Ines, Perez-Ayala, Ana, Maria Herrero, Juan, Lizasoain, Manuel, Rojo, Pablo, Matarranz, Mariano, Zarco, Carlos, Fernandez Suarez, Jonathan, Boga Ribeiro, Jose Antonio, Goikoetxea Aguirre, Josune, Zubero Sulibarria, Miren Zurine, Sanmartin Lopez, Juan Victor, Velasco Arribas, Maria, Penaranda Vera, Maria, Molina, Israel, Sanchez Montalva, Adrian, Salvador, Fernando, Monge-Maillo, Begona, Norman, Francesca, Chamorro Tojeiro, Sandra, Trevino-Maruri, Begoria, Serre Delcor, Nuria, Soriano-Arandes, Antonio, Pou Ciruelo, Diana, Bocanegra, Cristina, REDIVI Study Grp, Instituto de Salud Carlos III, European Regional Development Fund, Instituto de Salud Carlos III - ISCIII, and European Regional Development Fund (ERDF/FEDER)

Subjects
Adult, Male, medicine.medical_specialty, Pediatrics, 030231 tropical medicine, Neurocysticercosis, Disease, Albendazole, Serology, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, parasitic diseases, Taenia solium, medicine, Travel medicine, Humans, 030212 general & internal medicine, Retrospective Studies, business.industry, Cysticercosis, Public Health, Environmental and Occupational Health, Neglected Diseases, medicine.disease, Europe, medicine.drug_formulation_ingredient, Neglected diseases, Infectious Diseases, Spain, business, Imported infectious diseases, Travel Medicine, medicine.drug
Abstract

Background: Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology: Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results: 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions: Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened., We would thanks Maria Jesus Perteguer from the National Center of Microbiology for the information and update on NCC lab techniques currently performed in Spain. The corresponding author's affiliation centre belongs to the ISCIII-Sub. Gral. Redes-Network Biomedical Research on Tropical Diseases (RICET in Spanish) grant RD16CIII/0003/0001, RD16/0027/0020, RD16CIII/0003/0001 and the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2020

41. Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network

Author

Universidad de Sevilla. Departamento de Medicina, Herrador, Zaida, Pérez-Molina, José A., Henríquez Camacho, César Augusto, Rodriguez-Guardado, Azucena, Bosch-Nicolau, Pau, Calabuig, Eva, Domínguez Castellano, Angel, Bocanegra, Cristina, Universidad de Sevilla. Departamento de Medicina, Herrador, Zaida, Pérez-Molina, José A., Henríquez Camacho, César Augusto, Rodriguez-Guardado, Azucena, Bosch-Nicolau, Pau, Calabuig, Eva, Domínguez Castellano, Angel, and Bocanegra, Cristina

Abstract

Background Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened.

Published
2020

42. Epidemiological and clinical profile of immunosuppressed patients with imported strongyloidiasis: a substudy from a larger cohort of the +REDIVI Spanish Collaborative Network.

Author

Salvador, Fernando, primary, Treviño, Begoña, additional, Chamorro-Tojeiro, Sandra, additional, Pou, Diana, additional, Herrero-Martínez, Juan María, additional, Rodríguez-Guardado, Azucena, additional, Oliveira-Souto, Inés, additional, Torrús, Diego, additional, Goikoetxea, Josune, additional, Zubero, Zuriñe, additional, Velasco, María, additional, Bosch-Nicolau, Pau, additional, Aznar, Mª Luisa, additional, López-Vélez, Rogelio, additional, and Pérez-Molina, José A., additional

Published
2020
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44. Strongyloidiasis screening in migrants living in Spain: systematic review and meta‐analysis

Author

Salvador, Fernando, primary, Treviño, Begoña, additional, Bosch‐Nicolau, Pau, additional, Serre‐Delcor, Núria, additional, Sánchez‐Montalvá, Adrián, additional, Oliveira, Inés, additional, Sulleiro, Elena, additional, Aznar, Mª Luisa, additional, Pou, Diana, additional, Sao‐Avilés, Augusto, additional, and Molina, Israel, additional

Published
2019
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45. Strongyloidiasis screening in migrants living in Spain: systematic review and meta-analysis.

Author

Salvador, Fernando, Treviño, Begoña, Bosch‐Nicolau, Pau, Serre‐Delcor, Núria, Sánchez‐Montalvá, Adrián, Oliveira, Inés, Sulleiro, Elena, Aznar, Mª Luisa, Pou, Diana, Sao‐Avilés, Augusto, Molina, Israel, Bosch-Nicolau, Pau, Serre-Delcor, Núria, Sánchez-Montalvá, Adrián, and Sao-Avilés, Augusto

Subjects
IMMIGRANTS, META-analysis, SYSTEMATIC reviews, MEDICAL screening, SECERNENTEA infections
Abstract

Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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46. Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

Author

Strauss, Mariana, Acosta Herrera, Marialbert, Alcaraz, Alexia, Casares Marfil, Desiré, Bosch Nicolau, Pau, Lo Presti, Maria Silvina, Molina, Israel, González, Clara Isabel, Martín, Javier, Chagas Genetics CYTED Network, Universidad Nacional de Córdoba (Argentina), Ministerio de Ciencia y Tecnología de Córdoba (Argentina), Institut Català de la Salut, [Strauss M, Lo Presti MS] Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, FCM, INICSA-CONICET-UNC, Córdoba, Argentina. [Acosta-Herrera M, Alcaraz A, Casares-Marfil D] Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, España. [Bosch-Nicolau P, Molina I] Unitat de Medicina Tropical i Salut Internacional Drassanes, Vall d'Hebron Hospital Universitari, Barcelona, Spain. PROSICS, Barcelona, España, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Male, RC955-962, enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::tripanosomiasis::enfermedad de Chagas [ENFERMEDADES], Cohort Studies, 0302 clinical medicine, Mathematical and Statistical Techniques, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Ethnicities, Protozoans, Trypanosoma Cruzi, education.field_of_study, Statistics, Interleukin-18, Eukaryota, Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Trypanosoma::Trypanosoma cruzi [ORGANISMS], purl.org/becyt/ford/3.1 [https], Hispanic or Latino, Middle Aged, Metaanalysis, Population groupings, META-ANALYSIS, Malalties parasitàries, Infectious Diseases, Cohort, Physical Sciences, Amèrica Llatina, purl.org/becyt/ford/3 [https], Female, Public aspects of medicine, RA1-1270, Cardiomyopathies, Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease [DISEASES], Brazil, Cohort study, Research Article, Neglected Tropical Diseases, Chagas disease, Adult, Bolivia, Trypanosoma, Chagas, Malaltia de, Geographic Locations::Americas::Latin America [GEOGRAPHICALS], 030231 tropical medicine, Population, Argentina, Cardiology, Single-nucleotide polymorphism, Biology, Colombia, Research and Analysis Methods, Genetic Predisposition, Polymorphism, Single Nucleotide, 03 medical and health sciences, purl.org/becyt/ford/3.3 [https], Young Adult, TRYPANOSOMA CRUZI INFECTION, Genetic variation, parasitic diseases, Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Trypanosoma::Trypanosoma cruzi [ORGANISMOS], medicine, Genetic predisposition, Parasitic Diseases, Genetics, Humans, Chagas Disease, Genetic Predisposition to Disease, Allele, Statistical Methods, education, Aged, Evolutionary Biology, CARDIOMYOPATHY, Protozoan Infections, Population Biology, CHAGAS DISEASE, Public Health, Environmental and Occupational Health, IL18, Organisms, Biology and Life Sciences, Latin American people, medicine.disease, Tropical Diseases, Parasitic Protozoans, 030104 developmental biology, Latin America, Genetics of Disease, People and places, localizaciones geográficas::Américas::Latinoamérica [DENOMINACIONES GEOGRÁFICAS], Mathematics, Population Genetics, Demography
Abstract

Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66–0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64–0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied., This research was supported by grants from Ministerio de Ciencia y Tecnología de Córdoba (GRFT 2017, https://mincyt.cba.gov.ar/), Secretaría de Ciencia y Tecnología, Universidad Nacional de Córdoba, Argentina (https://www.unc.edu.ar/ciencia-y-tecnología/) and Red Iberoamericana de medicina genómica en enfermedad de Chagas - CYTED (http://www.cyted.org). Mariana Strauss performed the experimental work in this article during an internship at the Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, España. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2019

48. Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression

Author

Bosch-Nicolau, Pau, Ubals, Maria, Salvador, Fernando, Sánchez-Montalvá, Adrián, Aparicio, Gloria, Erra Duran, Alba, Martínez de Salazar, Pablo, Sulleiro Igual, Elena, Molina Romero, Israel, Universitat Autònoma de Barcelona, [Bosch-Nicolau P, Salvador F, Sánchez-Montalvá A, Molina I] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de salut internacional de l'Institut Català de la Salut (PROSICS), ICS, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Ubals M, Aparicio G] Servei de Dermatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Erra A] Servei de Reumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Martinez de Salazar P, Sulleiro E] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Programa de salut internacional de l'Institut Català de la Salut (PROSICS), ICS, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Male, Physiology, Biopsy, RC955-962, Gastroenterology, Etanercept, Medicaments antineoplàstics, 0302 clinical medicine, Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies::Retrospective Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Bone Marrow, Recurrence, Zoonoses, Immune Physiology, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Child, Leishmaniasis, Protozoans, Leishmania, Aged, 80 and over, Innate Immune System, Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis [DISEASES], Mediterranean Region, Eukaryota, Middle Aged, Infectious Diseases, enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis [ENFERMEDADES], Cytokines, Raonament basat en casos, Female, Public aspects of medicine, RA1-1270, Immunosuppressive Agents, medicine.drug, Research Article, Neglected Tropical Diseases, aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::monocinas::factor de necrosis tumoral alfa [COMPUESTOS QUÍMICOS Y DROGAS], Adult, medicine.medical_specialty, Adolescent, Leishmania Infantum, 030231 tropical medicine, Immunology, técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes::estudios retrospectivos [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Surgical and Invasive Medical Procedures, Rheumatoid Arthritis, Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha [CHEMICALS AND DRUGS], Injections, Intramuscular, Autoimmune Diseases, 03 medical and health sciences, Young Adult, Cutaneous leishmaniasis, Rheumatology, Leishmaniosi, Internal medicine, medicine, Adalimumab, Parasitic Diseases, Humans, Aged, Retrospective Studies, Miltefosine, Protozoan Infections, business.industry, Tumor Necrosis Factor-alpha, Arthritis, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Molecular Development, medicine.disease, Tropical Diseases, Infliximab, Golimumab, Parasitic Protozoans, 030104 developmental biology, Visceral leishmaniasis, Immune System, Clinical Immunology, Clinical Medicine, business, Developmental Biology, Systematic Reviews as Topic
Abstract

Background Tumor necrosis factor alpha (TNF-α) blockers are recognized as a risk factor for reactivation of granulomatous infections. Leishmaniasis has been associated with the use of these drugs, although few cases have been reported. Methodology We performed a retrospective observational study including patients with confirmed leishmaniasis acquired in the Mediterranean basin that were under TNF-α blockers therapy at the moment of the diagnosis. Patients diagnosed in our hospital from 2008 to 2018 were included. Moreover, a systematic review of the literature was performed and cases fulfilling the inclusion criteria were also included. Principal findings Forty-nine patients were analyzed including nine cases from our series. Twenty-seven (55.1%) cases were male and median age was 55 years. Twenty-five (51%) patients were under infliximab treatment, 20 (40.8%) were receiving adalimumab, 2 (4.1%) etanercept, one (2%) golimumab and one (2%) a non-specified TNF-α blocker. Regarding clinical presentation, 28 (57.1%) presented as cutaneous leishmaniasis (CL), 16 (32.6%) as visceral leishmaniasis (VL) and 5 (10.2%) as mucocutaneous leishmaniasis (MCL). All VL and MCL patients were treated with systemic therapies. Among CL patients, 13 (46.4%) were treated with a systemic drug (11 received L-AmB, one intramuscular antimonials and one miltefosine) while 14 (50%) patients were given local treatment (13 received intralesional pentavalent antimonials, and one excisional surgery). TNF-α blockers were interrupted in 32 patients (65.3%). After treatment 5 patients (10.2%) relapsed. Four patients with a CL (3 initially treated with local therapy maintaining TNF-α blockers and one treated with miltefosine) and one patient with VL treated with L-AmB maintaining TNF-α blockers. Conclusions This data supports the assumption that the blockage of TNF-α modifies clinical expression of leishmaniasis in endemic population modulating the expression of the disease leading to atypical presentations. According to the cases reported, the best treatment strategy would be a systemic drug and the discontinuation of the TNF-α blockers therapy until clinical resolution., Author summary Tumor necrosis factor alpha (TNF-α) blockers are widely used in numerous inflammatory diseases such rheumatoid arthritis, psoriasis or inflammatory bowel diseases. They have been recognized as a risk factor for reactivation of granulomatous infections. Although few cases have been reported, Leishmaniasis has been associated with the use of these drugs. Leishmania infantum is the main causative agent of leishmaniasis in Southern Europe and is prone to produce the visceral form. However, TNF-α has been implicated in the initial events of the infection mediating the disease expression. In our series, we have observed a surprisingly high proportion of cutaneous form (32.6%) and muco-cutaneous form (10.2%). Clinical outcome observed in this series is also unusual. Four cases (14.3%) with cutaneous leishmaniasis who received local therapy relapsed. Among patients with visceral leishmaniasis, one patient who maintained TNF-α blockers therapy relapsed despite etiological treatment. This data supports the assumption that the blockage of TNF-α modifies clinical expression of leishmaniasis leading to atypical presentations. According to the cases reported we proposed as best treatment strategy a systemic drug and the discontinuation of the TNF-α blockers therapy until clinical resolution.

Published
2019

49. Strongyloides stercoralis infection : A systematic review of endemic cases in Spain

Author

Barroso, Maria, Salvador, Fernando, Sánchez-Montalvá, Adrián, Bosch-Nicolau, Pau, Molina Romero, Israel, Barroso, Maria, Salvador, Fernando, Sánchez-Montalvá, Adrián, Bosch-Nicolau, Pau, and Molina Romero, Israel

Abstract

Strongyloides stercoralis infection, a neglected tropical disease, is widely distributed. Autochthonous cases have been described in Spain, probably infected long time ago. In recent years the number of diagnosed cases has increased due to the growing number of immigrants, travelers and refugees, but endemically acquired cases in Spain remains undetermined. We systematically searched the literature for references on endemic strongyloidiasis cases in Spain. The articles were required to describe Strongyloides stercoralis infection in at least one Spanish-born person without a history of travel to endemic areas and be published before 31st May 2018. Epidemiological data from patients was collected and described individually as well as risk factors to acquisition of the infection, diagnostic technique that lead to the diagnosis, presence of eosinophilia and clinical symptoms at diagnosis. Thirty-six studies were included, describing a total of 1083 patients with an average age of 68.3 years diagnosed with endemic strongyloidiasis in Spain. The vast majority of the cases were described in the province of Valencia (n = 1049). Two hundred and eight of the 251 (82.9%) patients in whom gender was reported were male, and most of them had current or past dedication to agriculture. Seventy percent had some kind of comorbidity. A decreasing trend in the diagnosed cases per year is observed from the end of last decade. However, there are still nefigw diagnoses of autochthonous cases of strongyloidiasis in Spain every year. With the data provided by this review it is likely that in Spain strongyloidiasis might have been underestimated. It is highly probable that the infection remains undiagnosed in many cases due to low clinical suspicion among Spanish population without recent travel history in which the contagion probably took place decades ago. S. stercoralis is a soil transmitted helminth that is common in many subtropical and tropical countries, but is also found in other re

Published
2019

50. A case report of long treatment with Itraconazole in a patient with chronic Chagas disease

Author

Bosch-Nicolau, Pau, Salvador, Fernando, Sánchez-Montalvá, Adrián, Sulleiro, Elena, Burgos, Joaquín, Molina Romero, Israel, Bosch-Nicolau, Pau, Salvador, Fernando, Sánchez-Montalvá, Adrián, Sulleiro, Elena, Burgos, Joaquín, and Molina Romero, Israel

Abstract

Background: Current available treatments (benznidazole and nifurtimox) for Chagas disease (CD) show limited efficacy in chronic phase and frequent undesirable effects. Ergosterol synthesis inhibitors (ESI) had been considered as promising drugs for CD treatment and despite its recent poor results in several clinical trials, different strategies have been proposed to optimize its role in this infection. Case presentation: We present a case of chronic Chagas disease in patient diagnosed with HIV who received treatment for histoplasmosis with itraconazol during twelve months. Even though T. cruzi rt-PCR was persistently negative during treatment, when itraconazol was stopped she presented with a positive blood rt-PCR. Conclusion: Several studies using different ESI had been published for CD treatment. Either in vitro or in vivo assays demonstrated activity against T. cruzi of the different triazole derivatives so different clinical trials had been carried out to evaluate its efficacy and safety. Despite contradictory evidence in the animal model, longer treatments along with other treatment strategies previously proposed suggests that ESI failure rates in positive peripheral blood rt-PCR are higher than that obtained with the current treatments of choice.

Published
2019

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