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2. Performance prediction equations for linear planar structural systems: Concept, formulation, and validation

Author

De Bortoli, M and Zareian, F

Subjects
Civil Engineering, Strategic, Defence & Security Studies, Strategic, Defence & Security Studies
Abstract

This paper presents and validates an analytical formulation, denoted as Performance Prediction Equations (PPEs), that relates the seismic response engineering demand parameter (EDP) of buildings to earthquake parameters such as magnitude, epicentral distance, and type of faulting. PPEs are conceptually novel and can be readily included in any hazard calculation program to directly estimate EDP hazard curves. The PPEs presented herein are based on the linear-ization of response spectrum analysis (RSA) formulation for estimation of the seismic response of multi-degree-of-freedom (MDOF) models for planar structural systems. Equations for mean and variance are provided for floor displacement, interstory drift ratio, and normalized base shear. The input parameters needed to apply the proposed PPEs are the modal properties of the structural system and the selection of an existing ground motion model (GMM). The proposed PPEs are validated against simulated results using a set of planar building models and the Campbell-Bozorgnia 2014 GMM. The comparison confirms that the proposed PPEs provide an accurate estimate of the statistics of the said EDPs.

Published
2018

4. GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy

Author

Volani, C, Pagliaro, A, Rainer, J, Paglia, G, Porro, B, Stadiotti, I, Foco, L, Cogliati, E, Paolin, A, Lagrasta, C, Frati, C, Corradini, E, Falco, A, Matzinger, T, Picard, A, Ermon, B, Piazza, S, De Bortoli, M, Tondo, C, Philippe, R, Medici, A, Lavdas, A, Blumer, M, Pompilio, G, Sommariva, E, Pramstaller, P, Troppmair, J, Meraviglia, V, Rossini, A, Volani C., Pagliaro A., Rainer J., Paglia G., Porro B., Stadiotti I., Foco L., Cogliati E., Paolin A., Lagrasta C., Frati C., Corradini E., Falco A., Matzinger T., Picard A., Ermon B., Piazza S., De Bortoli M., Tondo C., Philippe R., Medici A., Lavdas A. A., Blumer M. J. F., Pompilio G., Sommariva E., Pramstaller P. P., Troppmair J., Meraviglia V., Rossini A., Volani, C, Pagliaro, A, Rainer, J, Paglia, G, Porro, B, Stadiotti, I, Foco, L, Cogliati, E, Paolin, A, Lagrasta, C, Frati, C, Corradini, E, Falco, A, Matzinger, T, Picard, A, Ermon, B, Piazza, S, De Bortoli, M, Tondo, C, Philippe, R, Medici, A, Lavdas, A, Blumer, M, Pompilio, G, Sommariva, E, Pramstaller, P, Troppmair, J, Meraviglia, V, Rossini, A, Volani C., Pagliaro A., Rainer J., Paglia G., Porro B., Stadiotti I., Foco L., Cogliati E., Paolin A., Lagrasta C., Frati C., Corradini E., Falco A., Matzinger T., Picard A., Ermon B., Piazza S., De Bortoli M., Tondo C., Philippe R., Medici A., Lavdas A. A., Blumer M. J. F., Pompilio G., Sommariva E., Pramstaller P. P., Troppmair J., Meraviglia V., and Rossini A.

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a genetic disease associated with sudden cardiac death and cardiac fibro-fatty replacement. Over the last years, several works have demonstrated that different epigenetic enzymes can affect not only gene expression changes in cardiac diseases but also cellular metabolism. Specifically, the histone acetyltransferase GCN5 is known to facilitate adipogenesis and modulate cardiac metabolism in heart failure. Our group previously demonstrated that human primary cardiac stromal cells (CStCs) contribute to adipogenesis in the ACM pathology. Thus, this study aims to evaluate the role of GCN5 in ACM intracellular lipid accumulation. To do so, CStCs were obtained from right ventricle biopsies of ACM patients and from samples of healthy cadaveric donors (CTR). GCN5 expression was increased both in ex vivo and in vitro ACM samples compared to CTR. When GCN5 expression was silenced or pharmacologically inhibited by the administration of MB-3, we observed a reduction in lipid accumulation and a mitigation of reactive oxygen species (ROS) production in ACM CStCs. In agreement, transcriptome analysis revealed that the presence of MB-3 modified the expression of pathways related to cellular redox balance. Altogether, our findings suggest that GCN5 inhibition reduces fat accumulation in ACM CStCs, partially by modulating intracellular redox balance pathways.

Published
2022

8. Are human induced pluripotent stem cell derived cardiomyocytes a good cellular model for studying incomplete penetrance in arrhythmogenic cardiomyopathy?

Author

De Bortoli, M, primary, Meraviglia, V, additional, Mackova, K, additional, Volani, C, additional, Frommelt, LS, additional, Schlittler, M, additional, Cattelan, G, additional, Konig, E, additional, Rauhe, W, additional, Barbuti, A, additional, Zacchigna, S, additional, Pramstaller, PP, additional, and Rossini, A, additional

Published
2022
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10. Evidence of mitochondrial alterations in primary cardiac stromal cells from arrhythmogenic cardiomyopathy hearts

Author

Philippe, R, primary, Volani, C, additional, Medici, A, additional, Texler, B, additional, Pagliaro, A, additional, Stadiotti, I, additional, Meraviglia, V, additional, De Bortoli, M, additional, Guarino, A, additional, Blumer, M, additional, Pompilio, G, additional, Pramstaller, PP, additional, Sommariva, E, additional, Troppmair, J, additional, and Rossini, A, additional

Published
2022
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14. Chemical Quest: general knowledge and popular culture quizzes about the elements in a board game for the class

Author

Bortoli Marco, Balasso Antonella, Carta Giovanni, Cestaro Maristella, Colla Viviana, De Togni Alessandra, Gallani Giulio, Giacometti Cristina, Gianni Laura, Giuffreda Lucia, Granella Manuela, Iarabek Marina, Lion Enrico, Mazzi Giuseppe, Migale Caterina, Milan Stefano, Molesini Paola, Moretto Mara, Predonzan Roberta, Priolisi Ornella, Romualdi Rosella, Rubini Cristina, Scarfì Sandra, Tobaldini Elena, Dalla Tiezza Marco, Nale Enrico, Bellanda Massimo, Kennedy Gordon, Sella Gianpietro, Lanza Alessandro, and Orian Laura

Subjects
periodic table of elements, quizzes, chemical knowledge, popular culture, stem, clil, Chemistry, QD1-999
Abstract

Chemical Quest is an innovative trivia game based on the 102 elements of the periodic table from H to No, developed collaboratively by upper secondary school and university teachers with the aim of increasing the interest of young students (age 14–18) in chemistry. As part of the project, a software version of the game was successfully played in 24 classes. ‘Challenging, sometimes difficult, highly instructive, relaxing, captivating, ….’ are some of the positive comments by students and teachers. In addition, Chemical Quest was conceived to be adaptable since the rules can be modified and the cards can be selected to match the educational objective.

Published
2023
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15. Next Generation Sequencing identifies novel variants in TJP1, TP63 and PPP1R13L genes in Arrhythmogenic Cardiomyopathy patients

Author

Calore, M., Poloni, G., Postma, A. V., Lorenzon, A., Minervini, G., Vazza, G., Li Mura, I. E. A., Telatin, A., Zara, I., Simionati, B., Ponti, J., Occhi, G., Vitiello, L., Bauce, B., Tosatto, S. C. E., van Tintelen, P. J., Rampazzo, A., De Bortoli, M., Cardiologie, RS: FSE DMG, RS: CARIM - R2 - Cardiac function and failure, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: Carim - H05 Gene regulation, MUMC+: DA BV AIOS Nucleaire Geneeskunde (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and MUMC+: DA BV AIOS Radiologie (9)

Published
2019

17. KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern

Author

Teumer, A. (Alexander), Trenkwalder, T. (Teresa), Kessler, T. (Thorsten), Jamshidi, Y. (Yalda), Berg, M.E. (Marten) van den, Kaess, B. (Bernhard), Nelson, C.P. (Christopher P.), Bastiaenen, R. (Rachel), de Bortoli, M. (Marzia), Rossini, A. (Alessandra), Deisenhofer, I. (Isabel), Stark, K. (Klaus), Assa, S. (Solmaz), Braund, P.S. (Peter), Cabrera, C. (Claudia), Dominiczak, A.F. (Anna F.), Gögele, M. (Martin), Hall, L.M. (Leanne M.), Ikram, M.A. (Arfan), Kavousi, M. (Maryam), Lackner, K.J. (Karl), Study, L.C. (Lifelines Cohort), Müller, C., Münzel, T. (Thomas), Nauck, M. (Matthias), Padmanabhan, S. (Sandosh), Pfeiffer, A.F.H. (Andreas), Spector, T.D. (Timothy), Uitterlinden, A.G. (André), Verweij, N. (Niek), Völker, U. (Uwe), Warren, H. (Helen), Zafar, M. (Mobeen), Felix, S.B. (Stephan), Kors, J.A. (Jan), Snieder, H. (Harold), Munroe, P. (Patricia), Penninx, B.W.J.H., Fuchsberger, C. (Christian), Schmidt, G. (Georg), Nolte, I.M. (Ilja), Schunkert, H. (Heribert), Pramstaller, P.P. (Peter Paul), Wild, P.S. (Philipp), Harst, P. (Pim) van der, Stricker, B.H.Ch. (Bruno), Schnabel, R.B. (Renate), Samani, N.J. (Nilesh), Hengstenberg, C. (Christian), Dörr, M. (Marcus), Behr, E.R. (Elijah), Reinhard, W. (Wibke), Teumer, A. (Alexander), Trenkwalder, T. (Teresa), Kessler, T. (Thorsten), Jamshidi, Y. (Yalda), Berg, M.E. (Marten) van den, Kaess, B. (Bernhard), Nelson, C.P. (Christopher P.), Bastiaenen, R. (Rachel), de Bortoli, M. (Marzia), Rossini, A. (Alessandra), Deisenhofer, I. (Isabel), Stark, K. (Klaus), Assa, S. (Solmaz), Braund, P.S. (Peter), Cabrera, C. (Claudia), Dominiczak, A.F. (Anna F.), Gögele, M. (Martin), Hall, L.M. (Leanne M.), Ikram, M.A. (Arfan), Kavousi, M. (Maryam), Lackner, K.J. (Karl), Study, L.C. (Lifelines Cohort), Müller, C., Münzel, T. (Thomas), Nauck, M. (Matthias), Padmanabhan, S. (Sandosh), Pfeiffer, A.F.H. (Andreas), Spector, T.D. (Timothy), Uitterlinden, A.G. (André), Verweij, N. (Niek), Völker, U. (Uwe), Warren, H. (Helen), Zafar, M. (Mobeen), Felix, S.B. (Stephan), Kors, J.A. (Jan), Snieder, H. (Harold), Munroe, P. (Patricia), Penninx, B.W.J.H., Fuchsberger, C. (Christian), Schmidt, G. (Georg), Nolte, I.M. (Ilja), Schunkert, H. (Heribert), Pramstaller, P.P. (Peter Paul), Wild, P.S. (Philipp), Harst, P. (Pim) van der, Stricker, B.H.Ch. (Bruno), Schnabel, R.B. (Renate), Samani, N.J. (Nilesh), Hengstenberg, C. (Christian), Dörr, M. (Marcus), Behr, E.R. (Elijah), and Reinhard, W. (Wibke)

Abstract

BACKGROUND: The presence of an early repolarization pattern (ERP) on the surface ECG is associated with risk of ventricular fibrillation and sudden cardiac death. Family studies have shown that ERP is a highly heritable trait, but molecular genetic determinants are unknown. METHODS: To identify genetic susceptibility loci for ERP, we performed a GWAS and meta-analysis in 2,181 cases and 23,641 controls of European ancestry. RESULTS. We identified a genome-wide significant (P < 5 × 10-8) locus in the potassium voltage-gated channel subfamily D member 3 (KCND3) gene that was successfully replicated in additional 1,124 cases and 12,510 controls. A subsequent joint meta-analysis of the discovery and replication cohorts identified rs1545300 as the lead SNP at the KCND3 locus (OR 0.82 per minor T allele, P = 7.7 × 10-12) but did not reveal additional loci. Colocalization analyses indicate causal effects of KCND3 gene expression levels on ERP in both cardiac left ventricle and tibial artery. CONCLUSIONS: In this study, we identified for the first time to our knowledge a genome-wide significant association of a genetic variant with ERP. Our findings of a locus in the KCND3 gene provide insights not only into the genetic determinants but also into the pathophysiological mechanism of ERP, discovering a promising candidate for functional studies.

Published
2019
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22. Nature and strength of chalcogen-pi bonds

Author

Bortoli, M., Ahmad, Shah Masood, Hamlin, Trevor A., Bickelhaupt, F.Matthias, Orian, L., Bortoli, M., Ahmad, Shah Masood, Hamlin, Trevor A., Bickelhaupt, F.Matthias, and Orian, L.

Abstract

Item does not contain fulltext

Published
2018

23. Panipopituirarismo, sudorazione profusa e tumore: quale correlazione?

Author

Neri, M., Coghi, A., Balter, R., Bonetti, E., Chinello, M., De Bortoli, M., Pegoraro, A., Vitale, VALENTINA ANGELA, Zaccaron, A., Davi, M. V., Camoglio, F. S., and Cesaro, S.

Subjects
età pediatrica, ipertensione, feocromocitoma, feocromocitoma, ipertensione, età pediatrica
Published
2017

25. Analisi di sopravvivenza ed esiti nei pazienti pediatrici con tumore cerebrale in età pediatirca trattati presso il centro di oncoematologia pediatrica di Verona dal 1999 al 2017

Author

Coghi, A., Lorenzi, Maya, Tridello, G., De Bortoli, M., Panizzolo, I. S., Balter, R., Bonetti, E., Chinello, M., Pegoraro, A., Vitale, V., Zaccaron, A., Sala, F., Mazzarotto, Renzo, Pioli, Fabio, Ghimenton, C., and Cesaro, S.

Subjects
pediatria, tumori cerebrali, pediatria, medulloblastoma, medulloblastoma, tumori cerebrali
Published
2017

32. 073_16729-B2 Co-Inheritance of Mutations Associated With Arrhythmogenic Cardiomyopathy and Hypertrophic Cardiomyopathy

Author

De Bortoli, M., primary, Calore, C., additional, Lorenzon, A., additional, Calore, M., additional, Poloni, G., additional, Mazzotti, E., additional, Rigato, I., additional, Marra, M. Perazzolo, additional, Melacini, P., additional, Iliceto, S., additional, Thiene, G., additional, Basso, C., additional, Daliento, L., additional, Corrado, D., additional, Bauce, B., additional, and Rampazzo, A., additional

Published
2017
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34. Haploidentical HSCT with Post-Transplant High-Dose Cyclophosphamide in Children and Adolescents with High Risk Hematological Malignancies. A Retrospective Multicenter Study from the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Author

Berger, M., Lanino, E., Cesaro, Simone, Zecca, M., Masetti, R., Vassallo, E., De Bortoli, M., Mina, T., Belotti, T., Prete, A., and Fagioli, F.

Subjects
allogeneic stem cell transplantation, haploidentical, high-risk patients
Published
2015

36. Addition-Elimination or Nucleophilic Substitution? Understanding the Energy Profiles for the Reaction of Chalcogenolates with Dichalcogenides

Author

Bortoli, M., Wolters, L.P., Orian, L., Bickelhaupt, F.M., Bortoli, M., Wolters, L.P., Orian, L., and Bickelhaupt, F.M.

Abstract

Item does not contain fulltext, We have quantum chemically explored the mechanism of the substitution reaction between CH3X- and the homo- and heterodichalcogenides CH3X'X '' CH3 (X, X', X '' = S, Se, Te) using relativistic density functional theory at ZORA-OLYP/TZ2P and COSMO for simulating the effect of aqueous solvation. In the gas phase, all substitution reactions proceed via a triple-well additionelimination mechanism that involves a stable three-center intermediate. Aqueous solvation, in some cases, switches the character of the mechanism to double-well S(N)2 in which the stable three-center intermediate has become a labile transition state. We rationalize reactivity trends and some puzzling aspects of these elementary reactions, in particular, vanishing activation energies and ghost three-center intermediates, using the activation strain model (ASM).

Published
2016

37. Poster session 1Cell growth, differentiation and stem cells - Heart72Understanding the metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and differentiation?73Expression of pw1/peg3 identifies a new cardiac adult stem cell population involved in post-myocardial infarction remodeling74Long-term stimulation of iPS-derived cardiomyocytes using optogenetic techniques to promote phenotypic changes in E-C coupling75Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells76Constitutive beta-adrenoceptor-mediated cAMP production controls spontaneous automaticity of human induced pluripotent stem cell-derived cardiomyocytes77Formation and stability of T-tubules in cardiomyocytes78Identification of miRNAs promoting human cardiomyocyte proliferation by regulating Hippo pathway79A direct comparison of foetal to adult epicardial cell activation reveals distinct differences relevant for the post-injury response80Role of neuropilins in zebrafish heart regeneration81Highly efficient immunomagnetic purification of cardiomyocytes derived from human pluripotent stem cells82Cardiac progenitor cells posses a molecular circadian clock and display large 24-hour oscillations in proliferation and stress tolerance83Influence of sirolimus and everolimus on bone marrow-derived mesenchymal stem cell biology84Endoglin is important for epicardial behaviour following cardiac injuryCell death and apoptosis - Heart87Ultrastructural alterations reflecting Ca2+ handling and cell-to-cell coupling disorders precede occurrence of severe arrhythmias in intact animal heart88Urocortin-1 promotes cardioprotection through ERK1/2 and EPAC pathways: role in apoptosis and necrosis89Expression p38 MAPK and Cas-3 in myocardium LV of rats with experimental heart failure at melatonin and enalapril introductionTranscriptional control and RNA species - Heart92Accumulation of beta-amyloid 1-40 in HF patients: the role of lncRNA BACE1-AS93Role of miR-182 in zebrafish and mouse models of Holt-Oram syndrome94Mir-27 distinctly regulates muscle-enriched transcription factors and growth factors in cardiac and skeletal muscle cells95AF risk factors impair PITX2 expression leading to Wnt-microRNA-ion channel remodelingCytokines and cellular inflammation - Heart98Post-infarct survival depends on the interplay of monocytes, neutrophils and interferon gamma in a mouse model of myocardial Infarction99Inflammatory cd11b/c cells play a protective role in compensated cardiac hypertrophy by promoting an orai3-related pro-survival signal100Anti-inflammatory effects of endothelin receptor blockade in the atrial tissue of spontaneously hypertensive rats101Mesenchymal stromal cells reduce NLRP3 inflammasome activity in Coxsackievirus B3-induced myocarditis102Mesenchymal stromal cells modulate monocytes trafficking in Coxsackievirus B3-induced myocarditis103The impact of regulatory T lymphocytes on long-term mortality in patients with chronic heart failure104Temporal dynamics of dendritic cells after ST-elevation myocardial infarction relate with improvement of myocardial functionGrowth factors and neurohormones - Heart107Preconditioning of hypertrophied heart: miR-1 and IGF-1 crosstalk108Modulation of catecholamine secretion from human adrenal chromaffin cells by manipulation of G protein-coupled receptor kinase-2 activity109Evaluation of cyclic adenosin-3,5- monophosphate and neurohormones in patients with chronic heart failureNitric oxide and reactive oxygen species - Heart112Hydrogen sulfide donor inhibits oxidative and nitrosative stress, cardiohemodynamics disturbances and restores cNOS coupling in old rats113Role and mechanisms of action of aldehydes produced by monoamine oxidase A in cardiomyocyte death and heart failure114Exercise training has contrasting effects in myocardial infarction and pressure-overload due to different endothelial nitric oxide synthase regulation115S-Nitroso Human Serum Albumin dose-dependently leads to vasodilation and alters reactive hyperaemia in coronary arteries of an isolated mouse heart model116Modulating endothelial nitric oxide synthase with folic acid attenuates doxorubicin-induced cardiomyopathy119Effects of long-term very high intensity exercise on aortic structure and function in an animal model120Electron paramagnetic resonance spectroscopy quantification of nitrosylated hemoglobin (HbNO) as an index of vascular nitric oxide bioavailability in vivo121Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen speciesExtracellular matrix and fibrosis - Heart124MicroRNA-19b is associated with myocardial collagen cross-linking in patients with severe aortic stenosis. Potential usefulness as a circulating biomarker125A new ex vivo model to study cardiac fibrosis126Heterogeneity of fibrosis and fibroblast differentiation in the left ventricle after myocardial infarction127Effect of carbohydrate metabolism degree compensation to the level of galectin-3 changes in hypertensive patients with chronic heart failure and type 2 diabetes mellitus128Statin paradox in association with calcification of bicuspid aortic valve interstitial cells129Cardiac function remains impaired despite reversible cardiac fibrosis after healed experimental viral myocarditisIon channels, ion exchangers and cellular electrophysiology - Heart132Identifying a novel role for PMCA1 (Atp2b1) in heart rhythm instability133Mutations of the caveolin-3 gene as a predisposing factor for cardiac arrhythmias134The human sinoatrial node action potential: time for a computational model135iPSC-derived cardiomyocytes as a model to dissect ion current alterations of genetic atrial fibrillation136Postextrasystolic potentiation in healthy and diseased hearts: effects of the site of origin and coupling interval of the preceding extrasystole137Absence of Nav1.8-based (late) sodium current in rabbit cardiomyocytes and human iPSC-CMs138hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit cellular electrophysiological abnormalitiesMicrocirculation141Atherogenic indices, collagen type IV turnover and the development of microvascular complications- study in diabetics with arterial hypertension142Changes in the microvasculature and blood viscosity in women with rheumatoid arthritis, hypercholesterolemia and hypertensionAtherosclerosis145Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis146Obstructive sleep apnea causes aortic remodeling in a chronic murine model147Aortic perivascular adipose tissue displays an aged phenotype in early and late atherosclerosis in ApoE-/- mice148A systematic evaluation of the cellular innate immune response during the process of human atherosclerosis149Inhibition of Coagulation factor Xa increases plaque stability and attenuates the onset and progression of atherosclerotic plaque in apolipoprotein e-deficient mice150Regulatory CD4+ T cells from patients with atherosclerosis display pro-inflammatory skewing and enhanced suppression function151Hypoxia-inducible factor (HIF)-1alpha regulates macrophage energy metabolism by mediating miRNAs152Extracellular S100A4 is a key player of smooth muscle cell phenotypic transition: implications in atherosclerosis153Microparticles of healthy origins improve atherosclerosis-associated endothelial progenitor cell dysfunction via microRNA transfer154Arterial remodeling and metabolism impairment in early atherosclerosis155Role of pannexin1 in atherosclerotic plaque formationCalcium fluxes and excitation-contraction coupling158Amphiphysin II induces tubule formation in cardiac cells159Interleukin 1 beta regulation of connexin 43 in cardiac fibroblasts and the effects of adult cardiac myocyte:fibroblast co-culture on myocyte contraction160T-tubular electrical defects contribute to blunted beta-adrenergic response in heart failure161Beat-to-beat variability of intracellular Ca2+ dynamics of Purkinje cells in the infarct border zone of the mouse heart revealed by rapid-scanning confocal microscopy162The efficacy of late sodium current blockers in hypertrophic cardiomyopathy is dependent on genotype: a study on transgenic mouse models with different mutations163Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signalingContractile apparatus166Towards an engineered heart tissue model of HCM using hiPSC expressing the ACTC E99K mutation167Diastolic mechanical load delays structural and functional deterioration of ultrathin adult heart slices in culture168Structural investigation of the cardiac troponin complex by molecular dynamics169Exercise training restores myocardial and oxidative skeletal muscle function from myocardial infarction heart failure ratsOxygen sensing, ischaemia and reperfusion172A novel antibody specific to full-length stromal derived factor-1 alpha reveals that remote conditioning induces its cleavage by endothelial dipeptidyl peptidase 4173Attenuation of myocardial and vascular arginase activity by vagal nerve stimulation via a mechanism involving alpha-7 nicotinic receptor during cardiac ischemia and reperfusion174Novel nanoparticle-mediated medicine for myocardial ischemia-reperfusion injury simultaneously targeting mitochondrial injury and myocardial inflammation175Acetylcholine plays a key role in myocardial ischaemic preconditioning via recruitment of intrinsic cardiac ganglia176The role of nitric oxide and VEGFR-2 signaling in post ischemic revascularization and muscle recovery in aged hypercholesterolemic mice177Efficacy of ischemic preconditioning to protect the human myocardium: the role of clinical conditions and treatmentsCardiomyopathies and fibrosis180Plakophilin-2 haploinsufficiency leads to impaired canonical Wnt signaling in ARVC patient181Improved technique for customized, easier, safer and more reliable transverse aortic arch banding and debanding in mice as a model of pressure overload hypertrophy182Late sodium current inhibitors for the treatment of inducible obstruction and diastolic dysfunction in hypertrophic cardiomyopathy: a study on human myocardium183Angiotensin II receptor antagonist fimasartan has protective role of left ventricular fibrosis and remodeling in the rat ischemic heart184Role of High-Mobility Group Box 1 (HMGB1) redox state on cardiac fibroblasts activities and heart function after myocardial infarction185Atrial remodeling in hypertrophic cardiomyopathy: insights from mouse models carrying different mutations in cTnT186Electrophysiological abnormalities in ventricular cardiomyocytes from a Maine Coon cat with hypertrophic cardiomyopathy: effects of ranolazine187ZBTB17 is a novel cardiomyopathy candidate gene and regulates autophagy in the heart188Inhibition of SRSF4 in cardiomyocytes induces left ventricular hypertrophy189Molecular characterization of a novel cardiomyopathy related desmin frame shift mutation190Autonomic characterisation of electro-mechanical remodeling in an in-vitro leporine model of heart failure191Modulation of Ca2+-regulatory function by three novel mutations in TNNI3 associated with severe infant restrictive cardiomyopathyAging194The aging impact on cardiac mesenchymal like stromal cells (S+P+)195Reversal of premature aging markers after bariatric surgery196Sex-associated differences in vascular remodeling during aging: role of renin-angiotensin system197Role of the receptor for advanced glycation end-products (RAGE) in age dependent left ventricle dysfunctionsGenetics and epigenetics200hsa-miR-21-5p as a key factor in aortic remodeling during aneurysm formation201Co-inheritance of mutations associated with arrhythmogenic and hypertrophic cardiomyopathy in two Italian families202Lamin a/c hot spot codon 190: form various amino acid substitutions to clinical effects203Treatment with aspirin and atorvastatin attenuate cardiac injury induced by rat chest irradiation: Implication of myocardial miR-1, miR-21, connexin-43 and PKCGenomics, proteomics, metabolomics, lipidomics and glycomics206Differential phosphorylation of desmin at serines 27 and 31 drives the accumulation of preamyloid oligomers in heart failure207Potential role of kinase Akt2 in the reduced recovery of type 2 diabetic hearts subjected to ischemia / reperfusion injury208A proteomics comparison of extracellular matrix remodelling in porcine coronary arteries upon stent implantationMetabolism, diabetes mellitus and obesity211Targeting grk2 as therapeutic strategy for cancer associated to diabetes212Effects of salbutamol on large arterial stiffness in patients with metabolic syndrome213Circulating microRNA-1 and microRNA-133a: potential biomarkers of myocardial steatosis in type 2 diabetes mellitus214Anti-inflammatory nutrigenomic effects of hydroxytyrosol in human adipocytes - protective mechanisms of mediterranean diets in obesity-related inflammation215Alterations in the metal content of different cardiac regions within a rat model of diabetic cardiomyopathyTissue engineering218A novel conductive patch for application in cardiac tissue engineering219Establishment of a simplified and improved workflow from neonatal heart dissociation to cardiomyocyte purification and characterization220Effects of flexible substrate on cardiomyocytes cell culture221Mechanical stretching on cardiac adipose progenitors upregulates sarcomere-related genes

Author

Andre, E, primary, Yaniz-Galende, E, primary, Hamilton, C, primary, Dusting, G J, primary, Hellen, N, primary, Poulet, CE, primary, Diez Cunado, M, primary, Smits, AM, primary, Lowe, V, primary, Eckardt, D, primary, Du Pre, B, primary, Sanz Ruiz, R, primary, Moerkamp, A T, primary, Tribulova, N, primary, Smani, T, primary, Liskova, Y V, primary, Greco, S, primary, Guzzolino, E, primary, Franco, D, primary, Lozano-Velasco, E, primary, Knorr, M, primary, Pavoine, C, primary, Bukowska, A, primary, Van Linthout, S, primary, Miteva, K, primary, Sulzgruber, P, primary, Latet, S C, primary, Portnychenko, A, primary, Cannavo, A, primary, Kamilova, U, primary, Sagach, VF, primary, Santin, Y, primary, Octavia, Y, primary, Haller, PM, primary, Rubies, C, primary, Dei Zotti, F, primary, Wong, KHK, primary, Gonzalez Miqueo, A, primary, Kruithof, BPT, primary, Kadur Nagaraju, C, primary, Shaposhnikova, Y, primary, Songia, P, primary, Lindner, D, primary, Wilson, C, primary, Benzoni, P, primary, Fabbri, A, primary, Campostrini, G, primary, Jorge, E, primary, Casini, S, primary, Mengarelli, I, primary, Nikolov, A, primary, Bublikov, DS, primary, Kheloufi, M, primary, Walker, R E, primary, Van Dijk, RA, primary, Posthuma, JJ, primary, Dumitriu, I E, primary, Karshovska, E, primary, Sakic, A, primary, Alexandru, N, primary, Martin-Lorenzo, M, primary, Molica, F, primary, Taylor, RF, primary, Mcarthur, L, primary, Crocini, C, primary, Matsuyama, T-A, primary, Mazzoni, L, primary, Lin, W K, primary, Owen, TJ, primary, Scigliano, M, primary, Sheehan, A, primary, Bezerra Gurgel, A R, primary, Bromage, DI, primary, Kiss, A, primary, Ikeda, G, primary, Pickard, J M J, primary, Wirth, G, primary, Casos, K, primary, Khudiakov, A, primary, Nistal, JF, primary, Ferrantini, C, primary, Park, S-J, primary, Di Maggio, S, primary, Gentile, F, primary, Dini, L, primary, Buyandelger, B, primary, Larrasa-Alonso, J, primary, Schirmer, I, primary, Chin, SH, primary, Cimiotti, D, primary, Martini, 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Published
2016
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38. 4-IPP, a selective MIF inhibitor, causes mitotic catastrophe in thyroid carcinomas

Author

Varinelli, L, Caccia, D, Volpi, C, Caccia, C, De Bortoli, M, Taverna, E, Gualeni, A, Leoni, V, Gloghini, A, Manenti, G, Bongarzone, I, Volpi, CC, Gualeni, AV, Varinelli, L, Caccia, D, Volpi, C, Caccia, C, De Bortoli, M, Taverna, E, Gualeni, A, Leoni, V, Gloghini, A, Manenti, G, Bongarzone, I, Volpi, CC, and Gualeni, AV

Abstract

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is over-expressed in several human neoplastic cells. When MIF binds its receptor (CD74) and co-receptor (CD44), it initiates signaling cascades that orchestrate cell proliferation and survival, and it can directly modulate the activity of AMPK. These activities indicate that MIF potentially regulates cell survival and metabolism. We found that MIF was primarily co-expressed with CD74 in 16 out of 23 papillary thyroid carcinoma (PTC) and in all the 27 available anaplastic thyroid carcinoma (ATC) biopsy samples. MIF and CD74 were co-expressed in TPC-1 and HTC-C3 cell lines. The selective MIF inhibitor, 4-iodo-6- phenylpyrimidine (4-IPP), blocked MIF/CD74 internalization, activated JNK, and dosedependently inhibited proliferation inducing apoptosis and mitotic cell death. In two CD74-negative cell lines, NIM-1 and K1, 4-IPP treatment partially reduced proliferation. Coordinated MIF and CD74 expression appeared to confer in tumor cells the plasticity necessary to escape cell cycle regulation, metabolic changes, and stress conditions. MIF/CD74 signaling removal made cells susceptible to apoptosis and mitotic cell death. This finding suggests a possible avenue for targeting DNA endoreduplication, thus preventing the proliferation of therapy-resistant cell subpopulations. This study highlights MIF/CD74 axis as an important player in the biology of aggressive thyroid neoplasms.

Published
2015

41. Ostreopsis cf. ovata Fukuyo in the gulf of Trieste (Northern Adriatic sea): taxonomy, toxin content and ultrastructure

Author

Honsell, G, Battocchi, C, Blasutto, O, DE BORTOLI, M, Dellaversano, C, Boscolo, S, Marzari, R, Penna, Antonella, Tartaglione, L, Poli, M, Tubaro, A., K. Pagou, D.M. Anderson et al., G., Honsell, C., Battocchi, O., Blasutto, M., De Bortoli, Dell'Aversano, Carmela, S., Boscolo, R., Marzari, A., Penna, Tartaglione, Luciana, M., Poli, and A., Tubaro

Subjects
HR LC-MS, ovatoxin
Published
2010

44. TUMOUR BIOLOGY

Author

Geller, T., primary, Prakash, V., additional, Batanian, J., additional, Guzman, M., additional, Duncavage, E., additional, Gershon, T., additional, Crowther, A., additional, Wu, J., additional, Liu, H., additional, Fang, F., additional, Davis, I., additional, Tripolitsioti, D., additional, Ma, M., additional, Kumar, K., additional, Grahlert, J., additional, Egli, K., additional, Fiaschetti, G., additional, Shalaby, T., additional, Grotzer, M., additional, Baumgartner, M., additional, Braoudaki, M., additional, Lambrou, G. I., additional, Giannikou, K., additional, Millionis, V., additional, Papadodima, S. A., additional, Settas, N., additional, Sfakianos, G., additional, Stefanaki, K., additional, Kattamis, A., additional, Spiliopoulou, C. A., additional, Tzortzatou-Stathopoulou, F., additional, Kanavakis, E., additional, Gholamin, S., additional, Mitra, S., additional, Feroze, A., additional, Zhang, M., additional, Esparza, R., additional, Kahn, S., additional, Richard, C., additional, Achrol, A., additional, Volkmer, A., additional, Liu, J., additional, Volkmer, J., additional, Majeti, R., additional, Weissman, I., additional, Cheshier, S., additional, Bhatia, K., additional, Brown, N., additional, Teague, J., additional, Lo, P., additional, Challis, J., additional, Beshay, V., additional, Sullivan, M., additional, Mechinaud, F., additional, Hansford, J., additional, Arifin, M. Z., additional, Dahlan, R. H., additional, Sobana, M., additional, Saputra, P., additional, Tisell, M. 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Published
2014
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46. Evaluation of VOC measurements in the EXPOLIS study

Author

Jurvelin, J Edwards, R Saarela, K Laine-Ylijoki, J De Bortoli, M Oglesby, L Schlapfer, K Georgoulis, L and Tischerova, E Hanninen, O Jantunen, M

Abstract

Personal exposures and microenvironment concentrations of 30 target VOCs were measured for 401 participants living in five European cities as a part of the EXPOLIS (Air Pollution Exposure Distributions within Adult Urban Populations in Europe) study. Measurements in Basel used an active charcoal (Carbotech) adsorbent as opposed to the Tenax TA used in the other study centres. In addition, within each centre, personal and microenvironment VOC sampling required different sampling pumps and, because of different sampling durations, different sampling flow rates. Thus, careful testing of the sampling and analysis procedures was required to ensure accuracy and comparability of collected data. Monitor comparison tests using Tenax TA showed a mean VOC concentration ratio of 0.95 between the personal and microenvironment monitors. The LODs for the target VOCs using Tenax TA ranged from 0.7 to 5.2 mug m(-3). The LODs for the 14 target compounds quantifiable using Carbotech ranged from 0.9 to 3.2 mug m(-3). Tenax TA field blanks showed no remarkable contamination with the target VOCs, except benzaldehyde, a known artefact with this adsorbent. Thus, the diffusion barrier system used prevented contamination of Tenax TA samples by passive diffusion during non-sampling periods. Duplicate and parallel evaluations of the Tenax TA and Carbotech showed an average difference of

Published
2001

49. Techno-economic evaluation of narrowband and broadband access network alternatives and evolution scenario assessment

Author

Olsen, B.T. Zaganiaris, A. Stordahl, K. Ims, L.Aa. Myhre, D. Øverli, T. Tahkokorpi, M. Welling, I. Drieskens, M. Kraushaar, J. Mononen, J. Lähteenoja, M. Markatos, S. De Bortoli, M. Ferrero, U. Ravera, M. Balzaretti, S. Fleuren, F. Gieschen, N. De Oliveira Duarte, M. De Castro, E.

Abstract

The paper presents the main results obtained within the Research in Advanced Communications in Europe (RACE) project: 2087 TITAN (Tool for Introduction Scenarios and Techno-Economic Evaluation of The Access Network) regarding minimum-risk introductory routes for new narrowband and broadband services in the residential and small business market. The project developed a methodology and a tool for technoeconomic evaluation of advanced narrowband and broadband telecommunications networks and services. Results from four extensive access network studies are presented. For the narrowband services, optical access and radio in the local loop have been assessed and compared to conventional copper layout in a greenfield environment. Access network upgrade strategies for emerging new broadband services have been evaluated in three studies, with technological options ranging from enhanced copper to hybrid-fiber-coax (HFC) and broadband passive optical networks. An extensive study on different broadband access network upgrade alternatives for public network operators (PNO's) were carried out, taking into account the diversity of conditions met today by European countries. In another study, the effect of competition in the access network was modeled assuming two main operators sharing the market. Broadband upgrade alternatives were evaluated for a new cable operator, competing with the dominant public network operator. In addition, video-on-demand (VoD) and Internet access upgrades have been analyzed. The paper demonstrates the viability of techno-economic studies for the access network, including in-depth analysis of the time-dependence of component cost, tariffs, service-penetrations and market shares. This work intends to support establishing guidelines for strategic decisions regarding the development of the access network alternatives of different operators.

Published
1996

50. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

Author

Garlanda, C, Riva, F, Polentarutti, N, Buracchi, C, Sironi, M, De Bortoli, M, Muzio, M, Bergottini, R, Scanziani, E, Vecchi, A, Hirsch, E, Mantovani, A, Garlanda, C, Riva, F, Polentarutti, N, Buracchi, C, Sironi, M, De Bortoli, M, Muzio, M, Bergottini, R, Scanziani, E, Vecchi, A, Hirsch, E, and Mantovani, A

Abstract

TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Here we report that Tir8 has a unique pattern of expression, which includes mucosal tissues and dendritic cells (DC). Tir8-deficient DC showed increased cytokine production in response to TLR agonists (lipopolysaccharide, CpG oligodeoxynucleotides). Tir8-deficient mice had normal susceptibility to systemic lipopolysaccharide toxicity and to i.p. or s.c. inflammation. However, Tir8-deficient mice were more susceptible to intestinal inflammation. Thus, TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract.

Published
2004

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