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Your search keyword '"Blank, Randal S."' showing total 41 results
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41 results on '"Blank, Randal S."'

1. Recurrence-free survival after curative resection of non-small cell lung cancer between inhalational gas anesthesia and propofol-based total intravenous anesthesia: a multicenter, randomized, clinical trial (GAS TIVA trial): protocol description

Author

Kim, Jeayoun, Yoon, Susie, Song, In-Kyung, Lee, Kyuho, Hwang, Wonjung, Kim, Heezoo, Lee, Dong Kyu, Lim, Hyun Kyoung, Kim, Seong-Hyop, Lee, Jong Wha, Hong, Boohwi, Blank, Randal S., Pedoto, Alessia, Popescu, Wanda, Theresa, Glezinis, Martin, Archer Kilbourne, Patteril, Mathew, Pathanasethpong, Atipong, Thongsuk, Yada, Pisitpitayasaree, Tanatporn, Huang, Aijie, Yu, Hui, Kapoor, Poonam Malhotra, Kim, Kyunga, Chi, Sang Ah, and Ahn, Hyun Joo

Published
2024
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3. Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial

Author

Park, MiHye, Yoon, Susie, Nam, Jae-Sik, Ahn, Hyun Joo, Kim, Heezoo, Kim, Hye Jin, Choi, Hoon, Kim, Hong Kwan, Blank, Randal S., Yun, Sung-Cheol, Lee, Dong Kyu, Yang, Mikyung, Kim, Jie Ae, Song, Insun, Kim, Bo Rim, Bahk, Jae-Hyon, Kim, Juyoun, Lee, Sangho, Choi, In-Cheol, Oh, Young Jun, Hwang, Wonjung, Lim, Byung Gun, and Heo, Burn Young

Published
2023
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15. Airway driving pressure is associated with postoperative pulmonary complications after major abdominal surgery: a multicentre retrospective observational cohort study

Author

Douville, Nicholas J., primary, McMurry, Timothy L., additional, Ma, Jennie Z., additional, Naik, Bhiken I., additional, Mathis, Michael R., additional, Colquhoun, DouglasA., additional, Kheterpal, Sachin, additional, Pace, Nathan L., additional, Hedrick, Traci L., additional, Blank, Randal S., additional, Durieux, Marcel E., additional, Bender, Stephen Patrick, additional, and Holubar, Stefan D., additional

Published
2022
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21. A Lower Tidal Volume Regimen during One-lung Ventilation for Lung Resection Surgery Is Not Associated with Reduced Postoperative Pulmonary Complications

Author

Colquhoun, Douglas A., primary, Leis, Aleda M., additional, Shanks, Amy M., additional, Mathis, Michael R., additional, Naik, Bhiken I., additional, Durieux, Marcel E., additional, Kheterpal, Sachin, additional, Pace, Nathan L., additional, Popescu, Wanda M., additional, Schonberger, Robert B., additional, Kozower, Benjamin D., additional, Walters, Dustin M., additional, Blasberg, Justin D., additional, Chang, Andrew C., additional, Aziz, Michael F., additional, Harukuni, Izumi, additional, Tieu, Brandon H., additional, and Blank, Randal S., additional

Published
2021
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22. Development and Impact of an Institutional Enhanced Recovery Program on Opioid Use, Length of Stay, and Hospital Costs Within an Academic Medical Center: A Cohort Analysis of 7774 Patients

Author

Thiele, Robert H., primary, Sarosiek, Bethany M., additional, Modesitt, Susan C., additional, McMurry, Timothy L., additional, Tiouririne, Mohamed, additional, Martin, Linda W., additional, Blank, Randal S., additional, Shilling, Ashley, additional, Browne, James A., additional, Bogdonoff, David L., additional, Bauer, Todd W., additional, and Hedrick, Traci L., additional

Published
2020
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24. Management of One Lung Ventilation– Variation and Trends in Clinical Practice: A Report from the Multicenter Perioperative Outcomes Group (MPOG)

Author

Colquhoun, Douglas A., Naik, Bhiken I., Durieux, Marcel E., Shanks, Amy M., Kheterpal, Sachin, Bender, S. Patrick, and Blank, Randal S.

Subjects
Male, Research Report, Humans, Female, Patient Reported Outcome Measures, Article, Perioperative Care, One-Lung Ventilation
Abstract

Lung-protective ventilation (LPV) has been demonstrated to improve clinical outcomes in surgical patients. There are very limited data on the current use of LPV for patients undergoing 1-lung ventilation (1LV) despite evidence that 1LV may be a particularly important setting for its use. In this multicenter study, we report trends in ventilation practice for patients undergoing 1LV.The Multicenter Perioperative Outcomes Group database was used to identify patients undergoing 1LV. We retrieved and calculated median initial and overall tidal volume (VT) for the cohort and for high-risk subgroups (female sex, obesity [body mass index30 kg/m], and short stature), percentage of patients receiving positive end-expiratory pressure (PEEP) ≥5 cm H2O, LPV during 1LV (VT ≤ 6 mL/kg predicted body weight [PBW] and PEEP ≥5 cm H2O), and ventilator driving pressure (ΔP; plateau airway pressure - PEEP).Data from 5609 patients across 4 institutions were included in the analysis. Median VT was calculated for each case and since the data were normally distributed, the mean is reported for the entire cohort and subgroups. Mean of median VT during 1LV for the cohort was 6.49 ± 1.82 mL/kg PBW. VT (mL/kg PBW) for high-risk subgroups was significantly higher; 6.86 ± 1.97 for body mass index ≥30 kg/m, 7.05 ± 1.92 for female patients, and 7.33 ± 2.01 for short stature patients. Mean of the median VT declined significantly over the study period (from 6.88 to 5.72; P.001), and the proportion of patients receiving LPV increased significantly over the study period (from 9.1% to 54.6%; P.001). These changes coincided with a significant decrease in ΔP during the study period, from 19.4 cm H2O during period 1 to 17.3 cm H2O in period 12 (P = .003).Despite a growing awareness of the importance of protective ventilation, a large proportion of patients undergoing 1LV continue to receive VT PEEP levels outside of recommended thresholds. Moreover, VT remains higher and LPV less common in high-risk subgroups, potentially placing them at elevated risk for iatrogenic lung injury.

Published
2018

27. Management of One-lung Ventilation

Author

Blank, Randal S., primary, Colquhoun, Douglas A., additional, Durieux, Marcel E., additional, Kozower, Benjamin D., additional, McMurry, Timothy L., additional, Bender, S. Patrick, additional, and Naik, Bhiken I., additional

Published
2016
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28. Intraoperative Lung-Protective Ventilation Trends and Practice Patterns

Author

Bender, S. Patrick, primary, Paganelli, William C., additional, Gerety, Lyle P., additional, Tharp, William G., additional, Shanks, Amy M., additional, Housey, Michelle, additional, Blank, Randal S., additional, Colquhoun, Douglas A., additional, Fernandez-Bustamante, Ana, additional, Jameson, Leslie C., additional, and Kheterpal, Sachin, additional

Published
2015
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35. Fiberoptic Intubation: An Overview and Update.

Author

Collins, Stephen R. and Blank, Randal S.

Subjects
TRACHEA intubation, ANESTHESIA, AIRWAY (Anatomy), ALGORITHMS, DEAD, FIBER optics, PATIENT positioning, CONTINUING education units
Abstract

Fiberoptic intubation (FOI) is an effective technique for establishing airway access in patients with both anticipated and unanticipated difficult airways. First described in the late 1960s, this approach can facilitate airway management in a variety of clinical scenarios given proper patient preparation and technique. This paper seeks to review the pertinent technology, clinical techniques, and indications for and complications of its use. The role of FOI in airway management algorithms is discussed. Evidence is presented comparing FOI to other techniques with regard to difficult airway management. In addition, we have reviewed the literature on training processes and skill development in FOI. [ABSTRACT FROM AUTHOR]

Published
2014
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39. The Smooth Muscle α-Actin Gene Promoter Is Differentially Regulated in Smooth Muscle versusNon-smooth Muscle Cells (∗)

Author

Shimizu, Richard T., Blank, Randal S., Jervis, Ramiro, Lawrenz-Smith, Susan C., and Owens, Gary K.

Abstract

To identify potential regulators of smooth muscle cell (SMC) differentiation, we studied the molecular mechanisms that control the tissue-specific transcriptional expression of SM α-actin, the most abundant protein in fully differentiated SMCs. A construct containing the region from −1 to −125 of the promoter (p125CAT) had high transcriptional activity in SMCs (57-fold > promoterless) and endothelial cells (ECs) (18-fold) but not in skeletal myoblasts or myotubes. Mutation of either of two highly conserved CC(AT-rich)6GG (CArG) motifs at −62 and −112 abolished the activity of p125CAT in SMCs but had no effect in ECs. In contrast, high transcriptional activity in skeletal myotubes, which also express SM α-actin, required at least 271 base pairs of the promoter (−1 to ≥−271). Constructs containing 547 base pairs or more of the promoter were transcriptionally active in SMCs and skeletal myotubes but had no activity in skeletal myoblasts or ECs, cell types that do not express SM α-actin. Electrophoretic mobility shift assays provided evidence for binding of a unique serum response factor-containing complex of factors to the CArG box elements in SMCs. Results indicate that: 1) transcriptional expression of SM α-actin in SMCs requires the interaction of the CArG boxes with SMC nucleoprotein(s); 2) expression of SM α-actin in skeletal myotubes requires different cis-elements and trans-factors than in SMCs; and 3) negative-acting cis-elements are important in restricting transcription in cells that do not express SM α-actin.

Published
1995
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41. Special article: the endothelial glycocalyx: emerging concepts in pulmonary edema and acute lung injury.

Author

Collins SR, Blank RS, Deatherage LS, and Dull RO

Subjects
Algorithms, Capillary Permeability physiology, Humans, Lung surgery, Mechanotransduction, Cellular, Acute Lung Injury pathology, Endothelium pathology, Glycocalyx pathology, Pulmonary Edema pathology
Abstract

The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood. In this special article, we highlight key concepts of endothelial dysfunction with regards to the glycocalyx and provide new insights into the glycocalyx as a mediator of processes central to the development of pulmonary edema and lung injury.

Published
2013
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