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The paper reflects on La biblioteca pubblica e la sua reputazione, Maria Stella Rasetti's last book, published by Editrice bibliografica. The reflection starts from the reputation as object of study of different disciplines (such as communication, marketing, economics, sociology) and analyzes the importance of library reputation, closely associated with identity and image. Rasetti identifies four classes to place Italian public libraries and proposes a model to measure library reputation, adapted from business models, which uses personalized questionnaires for each class. The paper analyzes model validity and contextualizes it in the field of user satisfaction, performance and libraries impact. The hope is that measuring reputation can help public libraries to build a new narrative that overcomes public administration stereotypes of which they are victims, and to equip citizens with useful skills for work, everyday and social life, making them active and conscious protagonists. [ABSTRACT FROM AUTHOR]

The paper presents Peter Johan Lor’s book, International and comparative librarianship: concepts and methods for global studies (Berlin; Boston: De Gruyter Saur, 2019). As a result of a long research, the book shows the origins and the evolution of international and comparative librarianship as fields of study and research; it explains professional literature development on the subject; it deals with methodological aspects in terms of approaches, techniques and tools of comparison intended as a research strategy to analyze influences, divergences and consonances between different library contexts. Lor’s book is an opportunity for theoretical study but also a working tool, thanks also to the numerous examples that concern different geographic areas of the world and types of library as well as a variety of themes, functions and services. For its systematic approach, completeness and accuracy it is the most updated reference point for comparative studies, especially for library contexts, such as the Italian one, that are still too poor in reflections and real applications. [ABSTRACT FROM AUTHOR]

Music libraries are public or private institutions that collect a multiplicity of musical sources and materials of musical interest. They are special libraries with a strategic role for the institution, with wide and specialized collections and specialist music librarians that have to satisfy the needs of their own user communities. The article examines and discusses functions, services, requirements of music libraries and music librarians to underline that the interest of professional literature is confined almost exclusive to the collections, mainly to cataloging and conservation, without a solid analysis of the organization and management of library services. This applies to all music libraries and especially for Italian conservatoires and music schools libraries, whose data about service quality are poor. A music library is not just a storage of musical materials; especially in the field of music education, it has at least three functions: the conservation and the enhancement of music materials, the support for teaching and research and, last but not least, the cultural and social function for students, music teachers, researchers, musicians and for all citizens. Through the collection of data and evidences, service assessment then becomes an essential means to prove and increase these functions. [ABSTRACT FROM AUTHOR]

PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer, displays tumor suppressor activity by negatively modulating several proteins involved in proliferating signals. Here, through a proteomic-based approach, we identified a list of potential PTPRJ-interacting proteins and among them we focused on CD98hc, a type II glycosylated integral membrane protein encoded by SLC3A2 , corresponding to the heavy chain of a heterodimeric transmembrane amino-acid transporter, including LAT1. CD98hc is widely overexpressed in several types of cancers and contributes to the process of tumorigenesis by interfering with cell proliferation, adhesion, and migration. We first validated PTPRJ-CD98hc interaction, then demonstrated that PTPRJ overexpression dramatically reduces CD98hc protein levels in A549 lung cancer cells. In addition, following to the treatment of PTPRJ-transduced cells with MG132, a proteasome inhibitor, CD98hc levels did not decrease compared to controls, indicating that PTPRJ is involved in the regulation of CD98hc proteasomal degradation. Moreover, PTPRJ overexpression combined with CD98hc silencing consistently reduced cell proliferation and triggered apoptosis of lung cancer cells. Interestingly, by interrogating the can Evolve database, we observed an inverse correlation between PTPRJ and SLC3A2 gene expression. Indeed, the non-small cell lung cancers (NSCLCs) of patients showing a short survival rate express the lowest and the highest levels of PTPRJ and SLC3A2 , respectively. Therefore, the results reported here contribute to shed lights on PTPRJ signaling in cancer cells: moreover, our findings also support the development of a novel anticancer therapeutic approach by targeting the pathway of PTPRJ that is usually downregulated in highly malignant human neoplasias., Competing Interests: CONFLICTS OF INTEREST None.

PTPRJ is a receptor protein tyrosine phosphatase with tumor suppressor activity. Very little is known about the role of PTPRJ ectodomain, although recently both physiological and synthetic PTPRJ ligands have been identified. A putative shorter spliced variant, coding for a 539 aa protein corresponding to the extracellular N-terminus of PTPRJ, is reported in several databases but, currently, no further information is available.Here, we confirmed that the PTPRJ short isoform (named sPTPRJ) is a soluble protein secreted into the supernatant of both endothelial and tumor cells. Like PTPRJ, also sPTPRJ undergoes post-translational modifications such as glycosylation, as assessed by sPTPRJ immunoprecipitation. To characterize its functional activity, we performed an endothelial cell tube formation assay and a wound healing assay on HUVEC cells overexpressing sPTPRJ and we found that sPTPRJ has a proangiogenic activity. We also showed that sPTPRJ expression down-regulates endothelial adhesion molecules, that is a hallmark of proangiogenic activity. Moreover, sPTPRJ mRNA levels in human high-grade glioma, one of the most angiogenic tumors, are higher in tumor samples compared to controls. Further studies will be helpful not only to clarify the way sPTPRJ works but also to supply clues to circumvent its activity in cancer therapy.