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2. Nuclear miRNAs: Gene Regulation Activities.

Author

Billi, Monia, De Marinis, Elisabetta, Gentile, Martina, Nervi, Clara, and Grignani, Francesco

Subjects
*GENETIC regulation, *MICRORNA, *GENE enhancers, *MESSENGER RNA, *NON-coding RNA, *GENE expression
Abstract

MicroRNAs (miRNAs) are small non-coding RNAs which contribute to the regulation of many physiological and pathological processes. Conventionally, miRNAs perform their activity in the cytoplasm where they regulate gene expression by interacting in a sequence-specific manner with mature messenger RNAs. Recent studies point to the presence of mature miRNAs in the nucleus. This review summarizes current findings regarding the molecular activities of nuclear miRNAs. These molecules can regulate gene expression at the transcriptional level by directly binding DNA on the promoter or the enhancer of regulated genes. miRNAs recruit different protein complexes to these regions, resulting in activation or repression of transcription, through a number of molecular mechanisms. Hematopoiesis is presented as a paradigmatic biological process whereby nuclear miRNAs possess a relevant regulatory role. Nuclear miRNAs can influence gene expression by affecting nuclear mRNA processing and by regulating pri-miRNA maturation, thus impacting the biogenesis of miRNAs themselves. Overall, nuclear miRNAs are biologically active molecules that can be critical for the fine tuning of gene expression and deserve further studies in a number of physiological and pathological conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Genetic lesions disrupting calreticulin 3′‐untranslated region in JAK2 mutation‐negative polycythemia vera

Author

Quattrocchi, Alberto, primary, Maiorca, Carlo, additional, Billi, Monia, additional, Tomassini, Simona, additional, De Marinis, Elisabetta, additional, Cenfra, Natalia, additional, Equitani, Francesco, additional, Gentile, Martina, additional, Ceccherelli, Alessia, additional, Banella, Cristina, additional, Mecarocci, Sergio, additional, Scerpa, Maria Cristina, additional, Pisanò, Stefania, additional, Pacilli, Annalisa, additional, Di Cristofano, Claudio, additional, Mancini, Massimiliano, additional, Guglielmelli, Paola, additional, Vannucchi, Alessandro Maria, additional, Noguera, Nelida, additional, Grignani, Francesco, additional, Cimino, Giuseppe, additional, and Nervi, Clara, additional

Published
2020
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6. Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer

Author

Ulivi, Paola, primary, Petracci, Elisabetta, additional, Marisi, Giorgia, additional, Baglivo, Sara, additional, Chiari, Rita, additional, Billi, Monia, additional, Canale, Matteo, additional, Pasini, Luigi, additional, Racanicchi, Serena, additional, Vagheggini, Alessandro, additional, Delmonte, Angelo, additional, Mariotti, Marita, additional, Ludovini, Vienna, additional, Bonafè, Massimiliano, additional, Crinò, Lucio, additional, and Grignani, Francesco, additional

Published
2019
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7. Transcriptional targeting by microRNA-Polycomb complexes

Author

Zardo, Giuseppe, Ciolfi, Alberto, Vian, Laura, Billi, Monia, Racanicchi, Serena, Grignani, Francesco, and Nervi, Clara

Subjects
Extra Views, microRNA, Base Sequence, Models, Genetic, Transcription, Genetic, Polycomb-Group Proteins, Chromatin, chromatin remodeling, Epigenesis, Genetic, Hematopoiesis, Evolution, Molecular, MicroRNAs, microRNA-DNA interaction, Humans, Cell Lineage, transcriptional gene silencing, Promoter Regions, Genetic, Polycomb complexes
Abstract

Advances in the understanding of the epigenetic events underlying the regulation of developmental genes expression and cell lineage commitment are revealing novel regulatory networks. These also involve distinct components of the epigenetic pathways, including chromatin histone modification, DNA methylation, repression by polycomb complexes and microRNAs. Changes in chromatin structure, DNA methylation status and microRNA expression levels represent flexible, reversible and heritable mechanisms for the maintenance of stem cell states and cell fate decisions. We recently provided novel evidence showing that microRNAs, besides determining the post-transcriptional gene silencing of their targets, also bind to evolutionarily conserved complementary genomic seed-matches present on target gene promoters. At these sites, microRNAs can function as a critical interface between chromatin remodeling complexes and the genome for transcriptional gene silencing. Here, we discuss our novel findings supporting a role of the transcriptional chromatin targeting by polycomb-microRNA complexes in lineage fate determination of human hematopoietic cells.

Published
2012

10. Acute and chronic cannabidiol treatment: in vitro toxicological aspects on human oral cells.

Author

Marinucci, Lorella, Valenti, Chiara, Negri, Paolo, Billi, Monia, Di Michele, Alessandro, Bruscoli, Stefano, Coniglio, Maddalena, and Pagano, Stefano

Abstract

The article focuses on investigating the biological effects of acute and chronic CBD administration on gingival fibroblasts and oral keratinocytes, assessing cell viability, morphology, migration, apoptosis, cell cycle, gene expression, endocannabinoid system receptors, and DNA damage.

Published
2023

11. In vitro effects of electronic cigarette and heated tobacco product (IQOS) on oral cells.

Author

Marinucci, Lorella, Coniglio, Maddalena, Valenti, Chiara, Di Michele, Alessandro, Billi, Monia, Bruscoli, Stefano, Negri, Paolo, Lombardo, Guido, Cianetti, Stefano, and Pagano, Stefano

Subjects
ELECTRONIC cigarettes, TOBACCO products, POLAR effects (Chemistry), CIGARETTE smoke, SMOKING, ORAL mucosa
Abstract

The article presents a study on in vitro effects of electronic cigarette and heated tobacco product (IQOS) on oral cells. Topics include information on smoking related deaths annually in world; biological effects of electronic cigarette (e-cigarette) and heated tobacco product (IQOS) extracts on human gingival fibroblasts and human oral keratinocytes cells; and how cell viability is analysed by MTT assay.

Published
2022

13. ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological Spectrum

Author

Falini, Brunangelo, primary, Bigerna, Barbara, additional, Fizzotti, Marco, additional, Pulford, Karen, additional, Pileri, Stefano A., additional, Delsol, Georges, additional, Carbone, Antonino, additional, Paulli, Marco, additional, Magrini, Umberto, additional, Menestrina, Fabio, additional, Giardini, Roberto, additional, Pilotti, Silvana, additional, Mezzelani, Alessandra, additional, Ugolini, Barbara, additional, Billi, Monia, additional, Pucciarini, Alessandra, additional, Pacini, Roberta, additional, Pelicci, Pier-Giuseppe, additional, and Flenghi, Leonardo, additional

Published
1998
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