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1. The Multiple Object Test as a performance-based tool to assess the decline of ADL function in Parkinson's disease.

Author

Aline Beyle, Hannah Glonnegger, Bernhard Cerff, Susanne Gräber, Daniela Berg, and Inga Liepelt-Scarfone

Subjects
Medicine, Science
Abstract

INTRODUCTION:As cognitive-driven worsening of activities of the daily living (ADL) in Parkinson's disease (PD) is the core feature of PD dementia (PDD), there is great need for sensitive quantitative assessment. Aim of our study was the evaluation of cognitive-driven worsening of ADL by the performance-based Multiple Object Test (MOT), offering an essential clinical advantage as it is quick and easy to apply in a clinical context even on severely impaired patients. METHODS:73 PD patients were assessed longitudinally over a period of 37 (6-49) months. According to their neuropsychological profile the sample was divided into two groups: PD patients with (n = 34, PD-CI) and without cognitive impairment (n = 39, PD-noCI). The MOT comprises five routine tasks (e.g. to make coffee) quick and easy to apply. Quantitative (total error number, processing time) and qualitative parameters (error type) were analyzed using non-parametric test statistic (e.g.Wilcoxon signed-rank test, binary logistic regression). RESULTS:Median number of total errors (p = 0.001), processing time (p

Published
2018
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2. Home-Based Physical Behavior in Late Stage Parkinson Disease Dementia: Differences between Cognitive Subtypes

Author

Rob C. van Lummel, Susanne Gräber, Daniela Berg, Inga Liepelt-Scarfone, Jos Prinzen, Walter Maetzler, Bernhard Cerff, Silvia Del Din, Patricia Sulzer, Malte Kampmeyer, Dominik Blum, and Markus A. Hobert

Subjects
Male, Activities of daily living, Statistics as Topic, Pilot Projects, Disease, Neuropsychological Tests, 0302 clinical medicine, Activities of Daily Living, Accelerometry, physiology [Energy Metabolism], 030212 general & internal medicine, Aged, 80 and over, Parkinson Disease, Cognition, Middle Aged, Neurology, classification [Cognitive Dysfunction], Female, Psychology, diagnosis [Parkinson Disease], Locomotion, Algorithms, Adult, medicine.medical_specialty, Sitting, Statistics, Nonparametric, 03 medical and health sciences, physiology [Locomotion], Internal medicine, mental disorders, medicine, Dementia, Humans, Cognitive Dysfunction, ddc:610, Exercise, Aged, Odds ratio, medicine.disease, Confidence interval, Cross-Sectional Studies, diagnosis [Cognitive Dysfunction], psychology [Activities of Daily Living], Physical therapy, Neurology (clinical), Ordered logit, Energy Metabolism, human activities, physiology [Exercise], 030217 neurology & neurosurgery
Abstract

Background: For the early diagnosis of Parkinson disease dementia (PDD), objective home-based tools are needed to quantify even mild stages of dysfunction of the activities of daily living (ADL). Objectives: In this pilot study, home-based physical behavior was assessed to examine whether it is possible to distinguish mild cognitive impairment (PD-MCI) from PDD. Methods: Fifty-five patients with mild to severe Parkinson disease (PD) participated in this cross-sectional study. Based on comprehensive neuropsychological testing, PD patients were classified as cognitively nonimpaired (PD-NC), PD-MCI or PDD. For physical behavior assessments, patients wore the accelerometer DynaPort® (McRoberts) for 3 days. Ordinal logistic regression models with continuous Y were applied to correct results for motor impairment and depressive symptoms. Results: After excluding 7 patients due to insufficient wearing time, 48 patients with a mean of 2 recorded days were analyzed (17 PD-NC, 22 PD-MCI, 9 PDD). ADL-impaired PDD patients showed fewer sedentary bouts than non-ADL-impaired PD-MCI (p = 0.01, odds ratio [OR] = 8.9, 95% confidence interval [CI] = 1.8-45.2) and PD-NC (p = 0.01, OR = 10.3, CI = 1.6-67.3) patients, as well as a longer sedentary bout length (PD-NC: p = 0.02, OR = 0.1, CI = 0.02-0.65; PD-MCI: p = 0.02, OR = 0.14, CI = 0.03-0.69). These differences were mainly caused by fewer (PD-NC: p = 0.02, OR = 9.6, CI = 1.5-62.4; PD-MCI: p = 0.01, OR = 8.5, CI = 1.5-37.3) but longer sitting bouts (PD-NC: p = 0.03, OR = 0.12, CI = 0.02-0.80; PD-MCI: p = 0.04, OR = 0.19, CI = 0.04-0.93). Tests assessing executive function, visuoconstruction and attention correlated significantly with specific activity parameters (ρ ≥ 0.3; p < 0.05). Conclusion: Objective assessment of physical behavior, in particular the detection of sedentary bouts, is a promising contributor to the discrimination between PD-MCI and PDD.

Published
2017
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3. Front & Back Matter

Author

Hana Stufkova, Jessica Mandrioli, Amelia Conte, Federica Violi, Elmar H. Pinkhardt, Takahiro Fukuda, Maria Carmela Tartaglia, Yosr Bouhlal, Hans-Jürgen Huppertz, Andrew B. Singleton, Daniela Vidinska, Marie Coutelier, Carla Sanchis-Segura, Ai-Ling Shen, David S. Howland, Margot Samson, María Sol Fittipaldi-Márquez, Alexis Brice, Jos Prinzen, Marco Vinceti, Francesco Curcio, Sean B. Chong, Mario Sabatelli, Chien-Yeh Hsu, Satz Mengensatzproduktion, Nuno Sousa, Giovanni Stevanin, Samir Abu-Rumeileh, Peter Grill, Che-Yi Chou, Ricardo Taipa, Valeria A. Sansone, Monika Macakova, Daniela Berg, Rob van Lummel, Rim Amouri, Antonio Baldi, Hsiu-Chen Lin, Hisashi Hashimoto, Olga Vintonyak, Jiri Klima, Perrine Charles, Nova Sanvilli, Jinhui Ding, Yuan-Fu Tseng, Daniel O. Claassen, Antonio Belenguer, Jana Krizova, Sampath K. Arepalli, Marie Rodinova, Manuel Melo Pires, Christian Lunetta, Cristina Forn, Alexandra Durr, Elisa Majounie, Markus A. Hobert, Gian Luigi Gigli, Silvia Del Din, Martina Fabris, Andrew C Robinson, Ghada Eleuch-Fayache, Jan Motlik, Steven J. Clipman, Inga Liepelt-Scarfone, Faycal Hentati, Dominik Blum, Zdenka Ellederova, Bernhard Cerff, Druckerei Stückle, J. Raphael Gibbs, Bernhard Michalke, Hana Hansikova, Hsiu-Li Lin, Sebastiano D'Anna, Cassandra Jessica Anor, Hans-Peter Müller, Dena G. Hernandez, Malte Kampmeyer, Tomonori Kawabe, César Ávila, Lucio D'Anna, Fanny Mochel, Houda Nehdi, Bozena Bohuslavova, Monia B. Hammer, Paulo Brochado, Mariarosaria Valente, David M. A. Mann, Nikolay Solovyev, Patrício Costa, Walter Maetzler, David F. Tang-Wai, Álvaro Javier Cruz-Gómez, Ron Keren, Cinzia Pistis, Albert C. Ludolph, Martin Gorges, Patricia Sulzer, Antonin Pavlok, Moriaki Kusakabe, Susanne Gräber, Sean O'Connor, Jiri Zeman, Amardeep Saund, Inês Reis, and Jan Kassubek

Subjects
Optics, Neurology, business.industry, Neurology (clinical), Dermatology, business, Geology, Front (military)
Published
2012
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