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1. High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration

Author

Rusev, Stefan, Thon, Patrick, Dyck, Birte, Ziehe, Dominik, Rahmel, Tim, Marko, Britta, Palmowski, Lars, Nowak, Hartmuth, Ellger, Björn, Limper, Ulrich, Schwier, Elke, Henzler, Dietrich, Ehrentraut, Stefan Felix, Bergmann, Lars, Unterberg, Matthias, Adamzik, Michael, Koos, Björn, and Rump, Katharina

Published
2024
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4. Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis: A Prospective Cohort Study

Author

Adamzik, Michael, Adamzik, Stephanie, Bazzi, Maha, Bergmann, Lars, von Busch, Alexander, Haberl, Helge, Koos, Björn, Nowak, Hartmuth, Rahmel, Barbara, Rahmel, Tim, Rump, Katharina, Unterberg, Matthias, Willemsen, Katrin, Wolf, Alexander, Zuelch, Birgit, Anft, Moritz, Babel, Nina, Annecke, Thorsten, Defosse, Jerome M., Limper, Ulrich, Wappler, Frank, Bode, Christian, Ehrentraut, Stefan F., Putensen, Christian, Schewe, Jens-Christian, Bracht, Thilo, Sitek, Barbara, Eisennacher, Martin, Kleefisch, Daniel, Marcus, Katrin, Ellger, Björn, Oswald, Daniel, Ertmer, Christian, Zarbock, Alexander, Frey, Ulrich H., Fuchs, Katrin, Henzler, Dietrich, Köhler, Thomas, Schwier, Elke, Thon, Patrick, Trübner, Ellen, Zimmer, Frieda, Palmowski, Lars, Witowski, Andrea, Marko, Britta, and Ziehe, Dominik

Published
2024
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5. Risk assessment for major adverse cardiovascular events after noncardiac surgery using self-reported functional capacity: international prospective cohort study

Author

Lurati, Giovanna, Spadaro, Savino, Matute, Purificación, Ionescu, Daniela, Bolliger, Daniel, Szczeklik, Wojciech, Turhan, Sanem Cakar, van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Howell, Simon J., Gupta, Anil, De Hert, Stefan, Ovezov, Alexey, Tollinche, Luis E., Kuzmanovska, Biljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Fleischmann, Edith, Meistelman, Claude, Buggy, Donal J., Calleja, Paul, Hasani, Antigona, Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Piekarski, Florian, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Yeoh, Cindy B., Malinovska-Nikolovska, Liljana, Golubović, Mladjan, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Bonnet, Jean François, Cusack, Barbara, Nallbani, Rajmonda, Daamen, Sylvia, Plichon, Benoit, Harlet, Pierre, Farsi, Slama, Sepehr, Saman Homayun, Espinosa, David, Lurati Buse, Giovanna A., Mauermann, Eckhard, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, and Chammartin-Basnet, Frederique

Published
2023
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6. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Hemmes, Sabrine NT., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Uhlig, Christopher, Marín, Conrado Minguez, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Della Rocca, Giorgio, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe DJ., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Gil, Manuel Granell, Vidal Melo, Marcos F., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Ferrando, Carlos, Belda, Javier, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, Garcia del Valle, Santiago, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, Matta, Manuel de la, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Galve, Ana Isabel, Izquierdo, Ana, Jurado, Ana, Pérez, Ana María, Mugarra, Ana, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Román, Javie Ignacio, Acosta, Jesús, Rico-Feijoo, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., Pérez, Jose María, Marcos, Jose Miguel, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Mᵃ Justina, Tisner, Manuel, Barrio, María, Alonso, María Dolores, García, María, Hernández, María J., Alberola, María José, Parra, María, Argente, María Pilar, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Saleh Alfouzan, Rawan Abdullah, Alruqaie, Reef, Altermatt, Fernando, Luís de Castro Araujo, Bruno, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Tortosa, Isabel Belda, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Pérez, Elena Biosca, Birr, Katja, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Dincer, Pelin Corman, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, Junior, Paulo do Nascimento, Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Arı, Dilek Erdoğan, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Palahí, Christina Fortià, Galimberti, Andrea, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Ilić, Maja Karaman, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Barcelos, Gleicy Keli, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kivrak, Selin, Klarić, Vlasta, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Freitas de Lemos, Marília, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K., Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Pinheiro Módolo, Norma Sueli, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K., Murphy, Zoe, Nalwaya, Pramod, Naumovski, Filip, Navalesi, Paolo, Navarro e Lima, Lais Helena, Adam, Višnja Nesek, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, O'Connor, Michael, Oprea, Günther, Sungur, Mukadder Orhan, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Gonzalez, Estefania Palma, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Machado, Humberto S., Nunes, Catarina S., Sabbatini, Giovanni, Samuels, Jon D., Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Artiles, Tania Socorro, Castro, Diogo Sousa, Sousa, Miguel, Spadaro, Savino, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Altun, Gulbin Tore, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, Zhong, Jing, Campos, Niklas S., Librero, Julian, Ball, Lorenzo, and Serpa Neto, A.

Published
2022
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7. Psychometric Properties of Clinical Indicators for Identification and Management of Advanced Parkinson’s Disease: Real-World Evidence From G7 Countries

Author

Antonini, Angelo, Pahwa, Rajesh, Odin, Per, Henriksen, Tove, Soileau, Michael J., Rodriguez-Cruz, Ramon, Isaacson, Stuart H., Merola, Aristide, Lindvall, Susanna, Domingos, Josefa, Alobaidi, Ali, Jalundhwala, Yash J., Kandukuri, Prasanna L., Parra, Juan Carlos, Kukreja, Pavnit K., Onuk, Koray, Bergmann, Lars, Pike, James, and Ray Chaudhuri, K.

Published
2022
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8. The impact of the COVID-19 pandemic on non-COVID induced sepsis survival

Author

Unterberg, Matthias, Rahmel, Tim, Rump, Katharina, Wolf, Alexander, Haberl, Helge, von Busch, Alexander, Bergmann, Lars, Bracht, Thilo, Zarbock, Alexander, Ehrentraut, Stefan Felix, Putensen, Christian, Wappler, Frank, Köhler, Thomas, Ellger, Björn, Babel, Nina, Frey, Ulrich, Eisenacher, Martin, Kleefisch, Daniel, Marcus, Katrin, Sitek, Barbara, Adamzik, Michael, Koos, Björn, and Nowak, Hartmuth

Published
2022
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9. Does the 5–2-1 criteria identify patients with advanced Parkinson's disease? Real-world screening accuracy and burden of 5–2-1-positive patients in 7 countries

Author

Malaty, Irene A., Martinez-Martin, Pablo, Chaudhuri, K. Ray, Odin, Per, Skorvanek, Matej, Jimenez-Shahed, Joohi, Soileau, Michael J., Lindvall, Susanna, Domingos, Josefa, Jones, Sarah, Alobaidi, Ali, Jalundhwala, Yash J., Kandukuri, Prasanna L., Onuk, Koray, Bergmann, Lars, Femia, Samira, Lee, Michelle Y., Wright, Jack, and Antonini, Angelo

Published
2022
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10. Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis

Author

Ziehe, Dominik, primary, Wolf, Alexander, additional, Rahmel, Tim, additional, Nowak, Hartmuth, additional, Haberl, Helge, additional, Bergmann, Lars, additional, Rump, Katharina, additional, Dyck, Birte, additional, Palmowski, Lars, additional, Marko, Britta, additional, Witowski, Andrea, additional, Willemsen, Katrin Maria, additional, Pfaender, Stephanie, additional, Eisenacher, Martin, additional, Anft, Moritz, additional, Babel, Nina, additional, Bracht, Thilo, additional, Sitek, Barbara, additional, Bayer, Malte, additional, Zarbock, Alexander, additional, von Groote, Thilo, additional, Putensen, Christian, additional, Ehrentraut, Stefan Felix, additional, Weisheit, Christina, additional, Adamzik, Michael, additional, Unterberg, Matthias, additional, and Koos, Björn, additional

Published
2024
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12. Improved Sleep Correlates with Improved Quality of Life and Motor Symptoms with Foslevodopa/Foscarbidopa.

Author

Chaudhuri, K. Ray, Facheris, Maurizio F., Bergmans, Bruno, Bergquist, Filip, Criswell, Susan R., Jia, Jia, Kukreja, Pavnit, Mukai, Yohei, Spiegel, Amy M., Gupta, Resmi, Bergmann, Lars, and Pahwa, Rajesh

Subjects
QUALITY of life, PARKINSON'S disease, CLINICAL trials, PEARSON correlation (Statistics), SUBCUTANEOUS infusions
Abstract

Background: Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives: Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167). Methods: Pearson correlations between sleep (Parkinson's Disease Sleep Scale‐2 [PDSS‐2]) and quality of life (QoL; Parkinson's Disease Questionnaire‐39), motor experiences of daily living (m‐EDL; Movement Disorder Society‐Unified Parkinson's Disease Scale Part II), and "Off"/"On" times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS‐2 score. Results: Baseline sleep correlated moderately with QoL (r = 0.44, P < 0.001) and weakly with m‐EDL (r = 0.28; P < 0.001). Sleep improvement weakly correlated with improved "Off" time (r = 0.37; P < 0.001) and QoL (r = 0.36; P < 0.001). Regression analyses demonstrated significant positive associations for improved sleep, "Off" time, QoL, and m‐EDL. Conclusions: Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and "Off" time. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion

Author

Ziehe, Dominik, primary, Marko, Britta, additional, Thon, Patrick, additional, Rahmel, Tim, additional, Palmowski, Lars, additional, Nowak, Hartmuth, additional, von Busch, Alexander, additional, Wolf, Alexander, additional, Witowski, Andrea, additional, Vonheder, Jolene, additional, Ellger, Björn, additional, Wappler, Frank, additional, Schwier, Elke, additional, Henzler, Dietrich, additional, Köhler, Thomas, additional, Zarbock, Alexander, additional, Ehrentraut, Stefan Felix, additional, Putensen, Christian, additional, Frey, Ulrich Hermann, additional, Anft, Moritz, additional, Babel, Nina, additional, Adamzik, Michael, additional, Koos, Björn, additional, Bergmann, Lars, additional, Unterberg, Matthias, additional, and Rump, Katharina, additional

Published
2024
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14. AQP3 and AQP9—Contrary Players in Sepsis?

Author

Thon, Patrick, primary, Rahmel, Tim, additional, Ziehe, Dominik, additional, Palmowski, Lars, additional, Marko, Britta, additional, Nowak, Hartmuth, additional, Wolf, Alexander, additional, Witowski, Andrea, additional, Orlowski, Jennifer, additional, Ellger, Björn, additional, Wappler, Frank, additional, Schwier, Elke, additional, Henzler, Dietrich, additional, Köhler, Thomas, additional, Zarbock, Alexander, additional, Ehrentraut, Stefan Felix, additional, Putensen, Christian, additional, Frey, Ulrich Hermann, additional, Anft, Moritz, additional, Babel, Nina, additional, Sitek, Barbara, additional, Adamzik, Michael, additional, Bergmann, Lars, additional, Unterberg, Matthias, additional, Koos, Björn, additional, and Rump, Katharina, additional

Published
2024
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15. Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration—A New Potential Drug in Sepsis Therapy?

Author

Rump, Katharina, primary, Koos, Björn, additional, Ziehe, Dominik, additional, Thon, Patrick, additional, Rahmel, Tim, additional, Palmowski, Lars, additional, Marko, Britta, additional, Wolf, Alexander, additional, Witowski, Andrea, additional, Bazzi, Zainab, additional, Bazzi, Maha, additional, Orlowski, Jennifer, additional, Adamzik, Michael, additional, Bergmann, Lars, additional, and Unterberg, Matthias, additional

Published
2024
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16. The Association between the rs3747406 Polymorphism in the Glucocorticoid-Induced Leucine Zipper Gene and Sepsis Survivals Depends on the SOFA Score.

Author

Rusev, Stefan, Thon, Patrick, Rahmel, Tim, Ziehe, Dominik, Marko, Britta, Nowak, Hartmuth, Ellger, Björn, Limper, Ulrich, Schwier, Elke, Henzler, Dietrich, Ehrentraut, Stefan Felix, Bergmann, Lars, Unterberg, Matthias, Adamzik, Michael, Koos, Björn, and Rump, Katharina

Subjects
LEUCINE zippers, SEPSIS, SINGLE nucleotide polymorphisms, GENETIC variation, GENETIC polymorphisms, SOFAS
Abstract

The variability in mortality in sepsis could be a consequence of genetic variability. The glucocorticoid system and the intermediate TSC22D3 gene product—glucocorticoid-induced leucine zipper—are clinically relevant in sepsis, which is why this study aimed to clarify whether TSC22D3 gene polymorphisms contribute to the variance in sepsis mortality. Blood samples for DNA extraction were obtained from 455 patients with a sepsis diagnosis according to the Sepsis-III criteria and from 73 control subjects. A SNP TaqMan assay was used to detect single-nucleotide polymorphisms (SNPs) in the TSC22D3 gene. Statistical and graphical analyses were performed using the SPSS Statistics and GraphPad Prism software. C-allele carriers of rs3747406 have a 2.07-fold higher mortality rate when the sequential organ failure assessment (SOFA) score is higher than eight. In a multivariate COX regression model, the SNP rs3747406 with a SOFA score ≥ 8 was found to be an independent risk factor for 30-day survival in sepsis. The HR was calculated to be 2.12, with a p-value of 0.011. The wild-type allele was present in four out of six SNPs in our cohort. The promoter of TSC22D3 was found to be highly conserved. However, we discovered that the C-allele of rs3747406 poses a risk for sepsis mortality for SOFA Scores higher than 6. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Levodopa Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: DUOGLOBE Final 3-Year Results

Author

Chaudhuri, K. Ray, primary, Kovács, Norbert, additional, Pontieri, Francesco E., additional, Aldred, Jason, additional, Bourgeois, Paul, additional, Davis, Thomas L., additional, Cubo, Esther, additional, Anca-Herschkovitsch, Marieta, additional, Iansek, Robert, additional, Siddiqui, Mustafa S., additional, Simu, Mihaela, additional, Bergmann, Lars, additional, Ballina, Mayra, additional, Kukreja, Pavnit, additional, Ladhani, Omar, additional, Jia, Jia, additional, and Standaert, David G., additional

Published
2023
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21. The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis

Author

Thon, Patrick, primary, Rump, Katharina, additional, Knorr, Annika, additional, Dyck, Birte, additional, Ziehe, Dominik, additional, Unterberg, Matthias, additional, Nowak, Hartmuth, additional, Bergmann, Lars, additional, Wolf, Alexander, additional, Bazzi, Maha, additional, Orlowski, Jennifer, additional, Peters, Marcus, additional, Zarbock, Alexander, additional, Brenner, Thorsten, additional, Adamzik, Michael, additional, Rahmel, Tim, additional, and Koos, Björn, additional

Published
2022
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22. Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

Author

Rump, Katharina, primary, Holtkamp, Caroline, additional, Bergmann, Lars, additional, Nowak, Hartmuth, additional, Unterberg, Matthias, additional, Orlowski, Jennifer, additional, Thon, Patrick, additional, Bazzi, Zainab, additional, Bazzi, Maha, additional, Adamzik, Michael, additional, Koos, Björn, additional, and Rahmel, Tim, additional

Published
2022
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24. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults The HandiCAP Randomized Clinical Trial

Author

Meersch, Melanie, Weiss, Raphael, Kuellmar, Mira, Bergmann, Lars, Thompson, Astrid, Griep, Leonore, Kusmierz, Desiree, Buchholz, Annika, Wolf, Alexander, Nowak, Hartmuth, Rahmel, Tim, Adamzik, Michael, Haaker, Jan Gerrit, Goettker, Carina, Gruendel, Matthias, Hemping-Bovenkerk, Andre, Goebel, Ulrich, Braumann, Julius, Wisudanto, Irawan, Wenk, Manuel, Flores-Bergmann, Darius, Boehmer, Andreas, Cleophas, Sebastian, Hohn, Andreas, Houben, Anne, Ellerkmann, Richard K., Larmann, Jan, Sander, Julia, Weigand, Markus A., Eick, Nicolas, Ziemann, Sebastian, Bormann, Eike, Gerss, Joachim, Sessler, Daniel, I, Wempe, Carola, Massoth, Christina, Zarbock, Alexander, Meersch, Melanie, Weiss, Raphael, Kuellmar, Mira, Bergmann, Lars, Thompson, Astrid, Griep, Leonore, Kusmierz, Desiree, Buchholz, Annika, Wolf, Alexander, Nowak, Hartmuth, Rahmel, Tim, Adamzik, Michael, Haaker, Jan Gerrit, Goettker, Carina, Gruendel, Matthias, Hemping-Bovenkerk, Andre, Goebel, Ulrich, Braumann, Julius, Wisudanto, Irawan, Wenk, Manuel, Flores-Bergmann, Darius, Boehmer, Andreas, Cleophas, Sebastian, Hohn, Andreas, Houben, Anne, Ellerkmann, Richard K., Larmann, Jan, Sander, Julia, Weigand, Markus A., Eick, Nicolas, Ziemann, Sebastian, Bormann, Eike, Gerss, Joachim, Sessler, Daniel, I, Wempe, Carola, Massoth, Christina, and Zarbock, Alexander

Abstract

IMPORTANCE Intraoperative handovers of anesthesia care are common. Handovers might improve care by reducing physician fatigue, but there is also an inherent risk of losing critical information. Large observational analyses report associations between handover of anesthesia care and adverse events, including higher mortality. OBJECTIVE To determine the effect of handovers of anesthesia care on postoperative morbidity and mortality. DESIGN, SETTING, AND PARTICIPANTS This was a parallel-group, randomized clinical trial conducted in 12 German centers with patients enrolled between June 2019 and June 2021 (final follow-up, July 31, 2021). Eligible participants had an American Society of Anesthesiologists physical status 3 or 4 and were scheduled for major inpatient surgery expected to last at least 2 hours. INTERVENTIONS A total of 1817 participants were randomized to receive either a complete handover to receive anesthesia care by another clinician (n = 908) or no handover of anesthesia care (n = 909). None of the participating institutions used a standardized handover protocol. MAIN OUTCOMES AND MEASURES The primary outcome was a 30-day composite of all-cause mortality, hospital readmission, or serious postoperative complications. There were 19 secondary outcomes, including the components of the primary composite, along with intensive care unit and hospital lengths of stay. RESULTS Among 1817 randomized patients, 1772 (98%; mean age, 66 [SD, 12] years; 997 men [56%]; and 1717 [97%] with an American Society of Anesthesiologists physical status of 3) completed the trial. The median total duration of anesthesia was 267 minutes (IQR. 206-351 minutes), and the median time from start of anesthesia to first handover was 144 minutes in the handover group (IQR, 105-213 minutes). The composite primary outcome occurred in 268 of 891 patients (30%) in the handover group and in 284 of 881(33%) in the no handover group (absolute risk difference [RD], -2.5%; 95% CI, -6.8% to 1.9%; od

Published
2022

25. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Campos, Niklas S., primary, Bluth, Thomas, additional, Hemmes, Sabrine N.T., additional, Librero, Julian, additional, Pozo, Natividad, additional, Ferrando, Carlos, additional, Ball, Lorenzo, additional, Mazzinari, Guido, additional, Pelosi, Paolo, additional, Gama de Abreu, Marcelo, additional, Schultz, Marcus J., additional, Serpa Neto, A., additional, Hemmes, Sabrine NT., additional, Severgnini, Paolo, additional, Hollmann, Markus W., additional, Binnekade, Jan M., additional, Wrigge, Hermann, additional, Canet, Jaume, additional, Hiesmayr, Michael, additional, Schmid, Werner, additional, Tschernko, Edda, additional, Jaber, Samir, additional, Hedenstierna, Göran, additional, Putensen, Christian, additional, Marti, Agnes, additional, Bacuzzi, Alessandro, additional, Brodhun, Alexander, additional, Molin, Alexandre, additional, Merten, Alfred, additional, Parera, Ana, additional, Brunelli, Andrea, additional, Cortegiani, Andrea, additional, Güldner, Andreas, additional, Reske, Andreas W., additional, Gratarola, Angelo, additional, Giarratano, Antonino, additional, Bastin, Bea, additional, Heyse, Bjorn, additional, Mazul-Sunko, Branka, additional, Amantea, Bruno, additional, Barberis, Bruno, additional, Uhlig, Christopher, additional, Marín, Conrado Minguez, additional, Celentano, Cristian, additional, La Bella, Daniela, additional, D’Antini, David, additional, Velghe, David, additional, Sulemanji, Demet, additional, De Robertis, Edoardo, additional, Hartmann, Eric, additional, Montalto, Francesca, additional, Tropea, Francesco, additional, Mills, Gary H., additional, Cinnella, Gilda, additional, Della Rocca, Giorgio, additional, Caggianelli, Girolamo, additional, Pellerano, Giulia, additional, Mollica, Giuseppina, additional, Bugedo, Guillermo, additional, Mulier, Jan-Paul, additional, Vandenbrande, Jeroen, additional, Geib, Johann, additional, Yaqub, Jonathan, additional, Florez, Jorge, additional, Mayoral, Juan F., additional, Sprung, Juraj, additional, Van Limmen, Jurgen, additional, Bos, Lieuwe DJ., additional, de Baerdemaeker, Luc, additional, Jamaer, Luc, additional, Spagnolo, Luigi, additional, Strys, Lydia, additional, Gil, Manuel Granell, additional, Vidal Melo, Marcos F., additional, Unzueta, Maria Carmen, additional, Moral, Maria Victoria, additional, Ferner, Marion, additional, Weiss, Martin, additional, Vanoni, Massimo, additional, Schaefer, Maximilian S., additional, Prieto, Mercè, additional, Grio, Michele, additional, Spieth, Peter Markus, additional, Simon, Philipp, additional, Bodger, Phoebe, additional, Sierra, Pilar, additional, Laufenberg-Feldmann, Rita, additional, Rusca, Roberta, additional, Proietti, Rodolfo, additional, Raineri, Santi Maurizio, additional, Caroleo, Santo, additional, Sabaté, Sergi, additional, De Hert, Stefan, additional, Pezzato, Stefano, additional, Treschan, Tanja A., additional, Goranovic, Tatjana, additional, Koch, Thea, additional, Kiss, Thomas, additional, Perilli, Valter, additional, Cegarra, Virginia, additional, Belda, Javier, additional, Soro, Marina, additional, Unzueta, Carmen, additional, Suarez-Sipmann, Fernando, additional, Librero, Julián, additional, Llombart, Alicia, additional, Rovira, Lucas, additional, Granell, Manuel, additional, Aldecoa, César, additional, Diaz-Cambronero, Oscar, additional, Balust, Jaume, additional, Garutti, Ignacio, additional, Gonzalez, Rafael, additional, Gallego, Lucia, additional, Garcia del Valle, Santiago, additional, Redondo, Javier, additional, Pestaña, David, additional, Rodríguez, Aurelio, additional, García, Javier, additional, Matta, Manuel de la, additional, Ibáñez, Maite, additional, Barrios, Francisco, additional, Hernández, Samuel, additional, Torres, Vicente, additional, Peiró, Salvador, additional, Villena, Abigail, additional, Carramiñana, Albert, additional, Gallego-Casilda, Alberto, additional, Duca, Alejandro, additional, Alcón, Amalia, additional, Miñana, Amanda, additional, Asensio, Ana, additional, Colás, Ana, additional, Galve, Ana Isabel, additional, Izquierdo, Ana, additional, Jurado, Ana, additional, Pérez, Ana María, additional, Mugarra, Ana, additional, Gutierrez, Andrea, additional, De Miguel, Ángeles, additional, Lozano, Angels, additional, Katime, Antonio, additional, Romero, Antonio, additional, Garrigues, Beatriz, additional, Ayas, Begoña, additional, Arocas, Blanca, additional, Delgado, Carlos, additional, Fernández, Carmen, additional, Romero, Carolina, additional, Gallego, Clara, additional, Garcés, Cristina, additional, Lisbona, Cristina, additional, Parrilla, Cristina, additional, López-Herrera, Daniel, additional, González, Domingo, additional, Llamazares, Eduardo, additional, Del Rio, Elena, additional, Lozano, Elena, additional, Pastor, Ernesto, additional, Chamorro, Estefanía, additional, Gracia, Estefanía, additional, Sánchez, Ester, additional, Romero, Esther, additional, Díez, Fernando, additional, Serralta, Ferran, additional, Daviu, Francisco, additional, Sandín, Francisco, additional, Aguilar, Gerardo, additional, Tusman, Gerardo, additional, Azparren, Gonzalo, additional, Martínez-Pallí, Graciela, additional, Benítez, Inmaculada, additional, Hernandéz, Inmaculada, additional, India, Inmaculada, additional, León, Irene, additional, Fuentes, Isabel, additional, Ruiz, Isabel, additional, Puig, Jaume, additional, Román, Javie Ignacio, additional, Acosta, Jesús, additional, Rico-Feijoo, Jesús, additional, Olmedo, Jonathan, additional, Carbonell, Jose A., additional, Alonso, Jose M., additional, Pérez, Jose María, additional, Marcos, Jose Miguel, additional, Navarro, Jose, additional, Valdivia, Jose, additional, Carrizo, Juan, additional, Piqueras, Laura, additional, Soriano, Laura, additional, Vaquero, Laura, additional, Miguel, Lisset, additional, Muñoz, Lorena, additional, Valencia, Lucia, additional, Olmedilla, Luis, additional, Etulain, Mᵃ Justina, additional, Tisner, Manuel, additional, Barrio, María, additional, Alonso, María Dolores, additional, García, María, additional, Hernández, María J., additional, Alberola, María José, additional, Parra, María, additional, Argente, María Pilar, additional, Vila, María, additional, De Fez, Mario, additional, Agilaga, Marta, additional, Gine, Marta, additional, Ayuso, Mercedes, additional, García, Mercedes, additional, Bejarano, Natalia, additional, Peña, Natalia, additional, Ojeda, Nazario, additional, Martínez, Nilda, additional, García, Nuria, additional, Padrón, Oto, additional, García, Pablo, additional, Valls, Paola, additional, Cruz, Patricia, additional, Piñeiro, Patricia, additional, Charco, Pedro, additional, Anaya, Rafael, additional, López, Ramiro, additional, Rodríguez, Rayco, additional, Martínez, Rocío, additional, Pujol, Roger, additional, Dosdá, Rosa, additional, Lardies, Rosa, additional, Díaz, Ruben, additional, Villazala, Rubén, additional, Zapatero, Sara, additional, Cabrera, Sergio, additional, Sánchez, Sergio, additional, Martin, Silvia, additional, Diaz, Suzana, additional, Franco, Tania, additional, Moreno, Tania, additional, Socorro, Tania, additional, Gilabert, Vicente, additional, Balandrón, Victor, additional, Moral, Victoria, additional, Cegarra, Virgina, additional, Varón, Viviana, additional, Abelha, Fernando, additional, Abitağaoğlu, Sühayla, additional, Achilles, Marc, additional, Adebesin, Afeez, additional, Adriaensens, Ine, additional, Ahene, Charles, additional, Akbar, Fatima, additional, Al Harbi, Mohammed, additional, Al Khoury al Kallab, Rita, additional, Albanel, Xavier, additional, Aldenkortt, Florence, additional, Saleh Alfouzan, Rawan Abdullah, additional, Alruqaie, Reef, additional, Altermatt, Fernando, additional, Luís de Castro Araujo, Bruno, additional, Arbesú, Genaro, additional, Artsi, Hanna, additional, Aurilio, Caterina, additional, Ayanoglu, Omer Hilmi, additional, Baig, Harris, additional, Baird, Yolanda, additional, Balonov, Konstantin, additional, Banks, Samantha, additional, Bao, Xiaodong, additional, Baumgartner, Mélanie, additional, Tortosa, Isabel Belda, additional, Bergamaschi, Alice, additional, Bergmann, Lars, additional, Bigatello, Luca, additional, Pérez, Elena Biosca, additional, Birr, Katja, additional, Bojaxhi, Elird, additional, Bonenti, Chiara, additional, Bonney, Iwona, additional, Bos, Elke M.E., additional, Bowman, Sara, additional, Braz, Leandro Gobbo, additional, Brugnoni, Elisa, additional, Brull, Sorin J., additional, Brunetti, Iole, additional, Bruni, Andrea, additional, Buenvenida, Shonie L., additional, Busch, Cornelius Johannes, additional, Camerini, Giovanni, additional, Capatti, Beatrice, additional, Carmona, Javiera, additional, Carungcong, Jaime, additional, Carvalho, Marta, additional, Cattan, Anat, additional, Cavaleiro, Carla, additional, Chiumello, Davide, additional, Ciardo, Stefano, additional, Coburn, Mark, additional, Colella, Umberto, additional, Contreras, Victor, additional, Dincer, Pelin Corman, additional, Cotter, Elizabeth, additional, Crovetto, Marcia, additional, Darrah, William, additional, Davies, Simon, additional, Del Cojo Peces, Enrique, additional, Delphin, Ellise, additional, Diaper, John, additional, Junior, Paulo do Nascimento, additional, Donatiello, Valerio, additional, Dong, Jing, additional, Dourado, Maria do Socorro, additional, Dullenkopf, Alexander, additional, Ebner, Felix, additional, Elgendy, Hamed, additional, Ellenberger, Christoph, additional, Arı, Dilek Erdoğan, additional, Ermert, Thomas, additional, Farah, Fadi, additional, Fernandez-Bustamante, Ana, additional, Ferreira, Cristina, additional, Fiore, Marco, additional, Fonte, Ana, additional, Palahí, Christina Fortià, additional, Galimberti, Andrea, additional, Garofano, Najia, additional, Giaccari, Luca Gregorio, additional, Gilsanz, Fernando, additional, Girrbach, Felix, additional, Gobbi, Luca, additional, Godfried, Marc Bernard, additional, Goettel, Nicolai, additional, Goldstein, Peter A., additional, Goren, Or, additional, Gorlin, Andrew, additional, Graterol, Juan, additional, Guyon, Pierre, additional, Haire, Kevin, additional, Harou, Philippe, additional, Helf, Antonia, additional, Hempel, Gunther, additional, Hernández Cádiz, María José, additional, Heyse, Björn, additional, Huercio, Ivan, additional, Ilievska, Jasmina, additional, Jakus, Lien, additional, Jeganath, Vijay, additional, Jelting, Yvonne, additional, Jung, Minoa, additional, Kabon, Barbara, additional, Kacha, Aalok, additional, Ilić, Maja Karaman, additional, Karuppiah, Arunthevaraja, additional, Kavas, Ayse Duygu, additional, Barcelos, Gleicy Keli, additional, Kellogg, Todd A., additional, Kemper, Johann, additional, Kerbrat, Romain, additional, Khodr, Suraya, additional, Kienbaum, Peter, additional, Kir, Bunyamin, additional, Kivrak, Selin, additional, Klarić, Vlasta, additional, Köksal, Ceren, additional, Kowark, Ana, additional, Kranke, Peter, additional, Kuvaki, Bahar, additional, Kuzmanovska, Biljana, additional, Laffey, John, additional, Lange, Mirko, additional, Freitas de Lemos, Marília, additional, Licker, Marc-Joseph, additional, López-Baamonde, Manuel, additional, López-Hernández, Antonio, additional, Lopez-Martinez, Mercedes, additional, Luise, Stéphane, additional, MacGregor, Mark, additional, Magalhães, Danielle, additional, Maillard, Julien, additional, Malerbi, Patrizia, additional, Manimekalai, Natesan, additional, Margarson, Michael, additional, Markstaller, Klaus, additional, Martin, Archer K., additional, Martin, David P., additional, Martin, Yvette N., additional, Martínez-Ocon, Julia, additional, Martin-Loeches, Ignacio, additional, Maseda, Emilio, additional, Matot, Idit, additional, McAuliffe, Niamh, additional, McKenzie, Travis J., additional, Medina, Paulina, additional, Meersch, Melanie, additional, Menzen, Angelika, additional, Mertens, Els, additional, Meurer, Bernd, additional, Meyer-Treschan, Tanja, additional, Miao, Changhong, additional, Micalizzi, Camilla, additional, Milić, Morena, additional, Pinheiro Módolo, Norma Sueli, additional, Moine, Pierre, additional, Mölders, Patrick, additional, Montero-Feijoo, Ana, additional, Moret, Enrique, additional, Muller, Markus K., additional, Murphy, Zoe, additional, Nalwaya, Pramod, additional, Naumovski, Filip, additional, Navalesi, Paolo, additional, Navarro e Lima, Lais Helena, additional, Adam, Višnja Nesek, additional, Neumann, Claudia, additional, Newell, Christopher, additional, Nisnevitch, Zoulfira, additional, Nizamuddin, Junaid, additional, Novazzi, Cecilia, additional, O'Connor, Michael, additional, Oprea, Günther, additional, Sungur, Mukadder Orhan, additional, Özbilgin, Şule, additional, Pace, Maria Caterina, additional, Pacheco, Marcos, additional, Packianathaswamy, Balaji, additional, Gonzalez, Estefania Palma, additional, Papaspyros, Fotios, additional, Paredes, Sebastián, additional, Passavanti, Maria Beatrice, additional, Pedemonte, Juan Cristobal, additional, Peremin, Sanja, additional, Philipsenburg, Christoph, additional, Pinho, Daniela, additional, Pinho, Silvia, additional, Posthuma, Linda M., additional, Pota, Vincenzo, additional, Preckel, Benedikt, additional, Priani, Paolo, additional, Rached, Mohamed Aymen, additional, Radoeshki, Aleksandar, additional, Ragazzi, Riccardo, additional, Rajamanickam, Tamilselvan, additional, Rajamohan, Arthi, additional, Ramakrishna, Harish, additional, Rangarajan, Desikan, additional, Reiterer, Christian, additional, Renew, J. Ross, additional, Reynaud, Thomas, additional, Rhys, Rhidian, additional, Rivas, Eva, additional, Robitzky, Luisa, additional, Rossaint, Rolf, additional, Rubulotta, Francesca, additional, Machado, Humberto S., additional, Nunes, Catarina S., additional, Sabbatini, Giovanni, additional, Samuels, Jon D., additional, Sanahuja, Josep Martí, additional, Sansone, Pasquale, additional, Santos, Alice, additional, Sayedalahl, Mohamed, additional, Scharffenberg, Martin, additional, Schiffer, Eduardo, additional, Schliewe, Nadja, additional, Schorer, Raoul, additional, Schumann, Roman, additional, Selmo, Gabriele, additional, Sendra, Mar, additional, Senturk, Mert, additional, Shaw, Kate, additional, Shosholcheva, Mirjana, additional, Sibai, Abdulrazak, additional, Simonassi, Francesca, additional, Sinno, Claudia, additional, Sivrikoz, Nukhet, additional, Skandalou, Vasiliki, additional, Smith, Neil, additional, Soares, Maria, additional, Artiles, Tania Socorro, additional, Castro, Diogo Sousa, additional, Sousa, Miguel, additional, Spadaro, Savino, additional, Stamatakis, Emmanouil, additional, Steiner, Luzius A., additional, Stevenazzi, Andrea, additional, Suarez-de-la-Rica, Alejandro, additional, Suppan, Mélanie, additional, Teichmann, Robert, additional, Tena Guerrero, José Maria, additional, Thiel, Bram, additional, Tolós, Raquel, additional, Altun, Gulbin Tore, additional, Tucci, Michelle, additional, Turnbull, Zachary A., additional, Turudić, Žana, additional, Unterberg, Matthias, additional, Van Nieuwenhove, Yves, additional, Van Waesberghe, Julia, additional, Vidal Melo, Marcos Francisco, additional, Vitković, Bibiana, additional, Vivona, Luigi, additional, Vizcaychipi, Marcela, additional, Volta, Carlo Alberto, additional, Weber, Anne, additional, Weingarten, Toby N., additional, Wittenstein, Jakob, additional, Wyffels, Piet, additional, Yagüe, Julio, additional, Yates, David, additional, Yavru, Ayşen, additional, Zac, Lilach, additional, and Zhong, Jing, additional

Published
2022
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27. Additional file 1 of Does the 5���2-1 criteria identify patients with advanced Parkinson's disease? Real-world screening accuracy and burden of 5���2-1-positive patients in 7 countries

Author

Malaty, Irene A., Martinez-Martin, Pablo, Chaudhuri, K. Ray, Odin, Per, Skorvanek, Matej, Jimenez-Shahed, Joohi, Soileau, Michael J., Lindvall, Susanna, Domingos, Josefa, Jones, Sarah, Alobaidi, Ali, Jalundhwala, Yash J., Kandukuri, Prasanna L., Onuk, Koray, Bergmann, Lars, Femia, Samira, Lee, Michelle Y., Wright, Jack, and Antonini, Angelo

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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29. DUOGLOBE : One‐Year Outcomes in a Real‐World Study of Levodopa Carbidopa Intestinal Gel for Parkinson's Disease

Author

Standaert, David G., primary, Aldred, Jason, additional, Anca‐Herschkovitsch, Marieta, additional, Bourgeois, Paul, additional, Cubo, Esther, additional, Davis, Thomas L., additional, Iansek, Robert, additional, Kovács, Norbert, additional, Pontieri, Francesco E., additional, Siddiqui, Mustafa S., additional, Simu, Mihaela, additional, Bergmann, Lars, additional, Kukreja, Pavnit, additional, Robieson, Weining Z., additional, and Chaudhuri, K. Ray, additional

Published
2021
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31. The \(\it NF{\kappa}B1\) promoter polymorphism (-94ins/delATTG) is associated with susceptibility to cytomegalovirus infection after kidney transplantation and should have implications on CMV prophylaxis regimens

Author

Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Vornweg, Svenja (Dr. med.), Rump, Katharina (Dr. rer. nat.), Rahmel, Tim (Dr. med.), Unterberg, Matthias, Koos, Björn, Schenker, Peter (Prof. Dr. med.), Viebahn, Richard (Prof. Dr. med.), Adamzik, Michael (Prof. Dr. med.), and Bergmann, Lars (Dr. med.)

Subjects
virus diseases
Abstract

Infections with cytomegalovirus (CMV) are one of the most frequent opportunistic infections in kidney transplant recipients. Current risk-adapted CMV chemoprophylaxis regimens are based almost solely on the donor and recipient CMV serostatus. Of note, the \(\it NF{\kappa}B1\) -94ins/delATTG promoter polymorphism was recently associated with a higher risk of CMV infection. Since single genetic association studies suffer from poor reliability for drawing therapeutic implications, we performed this confirmatory study and included 256 kidney transplant recipients from 2007 to 2014 in this retrospective study. Patients were genotyped for the -94ins/delATTG \(\it NF{\kappa}B1\) promoter polymorphism and followed up for 12 months. The incidence of CMV infection within 12 months after kidney transplantation was 37.5% (33/88) for the ins/ins, 21.5% (28/130) for the ins/del, and 23.7% (9/38) for the del/del genotypes (\(\it p\) = 0.023). Moreover, we evaluated the time of CMV infection onset. Ins/ins carriers had primarily late-onset CMV infection (median 194 days; interquartile range (IQR) 117–267 days) compared with heterozygous (ins/del; median 158 days; IQR 82–195 days) and homozygous deletion allele carriers (del/del; median 95 days; 84–123 days). Multivariate-restricted Cox regression model confirmed the ins/ins genotype to be an independent risk factor for the development of late-onset CMV infections. These findings should have an impact on post-kidney transplantation CMV chemoprophylaxis regimens.

Published
2021

32. The aquaporin 3 promoter polymorphism − 1431 A/G is associated with acute graft rejection and cytomegalovirus infection in kidney recipients due to altered immune cell migration

Author

Rump, Katharina (Dr. rer. nat.), Rahmel, Tim (Dr. med.), Rustige, Anna-Maria (Dr. med.), Unterberg, Matthias, Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Koos, Björn, Schenker, Peter (Prof. Dr. med.), Viebahn, Richard (Prof. Dr. med.), Adamzik, Michael (Prof. Dr. med.), and Bergmann, Lars (Dr. med.)

Subjects
ddc:610
Abstract

Major complications after kidney transplantation are graft rejection and cytomegalovirus (CMV) infection, which are related to T-cell function, which depends on aquaporin 3 (AQP3) expression. The impact of the AQP3 A(−1431)G promoter polymorphism in kidney transplant recipients was unelucidated and we explored the effect of AQP3 polymorphism on immune cell function and its association with graft rejection and CMV infection in 237 adult patients within 12 months after transplantation. AQP3 promoter polymorphism was molecular and functional characterized. Kaplan–Meier plots evaluated the relationship between genotypes and the incidence of CMV infection and graft rejection. AQP3 A(−1431)G A-allele was associated with enhanced immune cell migration and AQP3 expression in T-cells. The incidences of rejection were 45.4% for the A-allele and 27.1% for G-allele carriers (\(\it p\) = 0.005) and the A-allele was a strong risk factor (hazard ratio (HR): 1.95; 95% CI: 1.216 to 3.127; \(\it p\) = 0.006). The incidences for CMV infection were 21% for A-allele and 35% for G-allele carriers (\(\it p\) = 0.013) and G-allele was an independent risk factor (\(\it p\) = 0.023), with a doubled risk for CMV infection (HR: 1.9; 95% CI: 1.154 to 3.128; \(\it p\) = 0.012). Hence, A-allele confers more resistance against CMV infection, but susceptibility to graft rejection mediated by T-cells. Thus, AQP3-genotype adapted management of immunosuppression and antiviral prophylaxis after kidney transplantation seems prudent.

Published
2020

33. The Aquaporin3 Promoter Polymorphism −1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration

Author

Rump, Katharina, Rahmel, Tim, Rustige, Anna-Maria, Unterberg, Matthias, Nowak, Hartmuth, Koos, Björn, Schenker, Peter, Viebahn, Richard, Adamzik, Michael, and Bergmann, Lars

Subjects
AQP3 −1431 A/G, virus diseases, kidney transplantation, migration, AQP3, polymorphism, surgical procedures, operative, lcsh:Biology (General), rejection, aquaporin 3, CMV infection, cytomegalovirus, lcsh:QH301-705.5, rs3860987
Abstract

Major complications after kidney transplantation are graft rejection and cytomegalovirus (CMV) infection, which are related to T-cell function, which depends on aquaporin3 (AQP3) expression. The impact of the AQP3 A(&minus, 1431)G promoter polymorphism in kidney transplant recipients was unelucidated and we explored the effect of AQP3 polymorphism on immune cell function and its association with graft rejection and CMV infection in 237 adult patients within 12 months after transplantation. AQP3 promoter polymorphism was molecular and functional characterized. Kaplan&ndash, Meier plots evaluated the relationship between genotypes and the incidence of CMV infection and graft rejection. AQP3 A(&minus, 1431)G A-allele was associated with enhanced immune cell migration and AQP3 expression in T-cells. The incidences of rejection were 45.4% for the A-allele and 27.1% for G-allele carriers (p = 0.005) and the A-allele was a strong risk factor (hazard ratio (HR): 1.95, 95%CI: 1.216 to 3.127, p = 0.006). The incidences for CMV infection were 21% for A-allele and 35% for G-allele carriers (p = 0.013) and G-allele was an independent risk factor (p = 0.023), with a doubled risk for CMV infection (HR: 1.9, 95%CI: 1.154 to 3.128, p = 0.012). Hence, A-allele confers more resistance against CMV infection, but susceptibility to graft rejection mediated by T-cells. Thus, AQP3-genotype adapted management of immunosuppression and antiviral prophylaxis after kidney transplantation seems prudent.

Published
2020

34. Major adverse kidney events are associated with the aquaporin 5-1364A/C promoter polymorphism in sepsis

Author

Bergmann, Lars (Dr. med.), Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Siffert, Winfried (Prof. Dr. med.), Peters, Jürgen, Adamzik, Michael (Prof. Dr. med.), Koos, Björn, and Rahmel, Tim (Dr. med.)

Subjects
ddc:610
Abstract

Since the functionally important \(\it AQP5\) -1364A/C single nucleotide promoter polymorphism alters key mechanisms of inflammation and survival in sepsis, it may affect the risk of an acute kidney injury. Accordingly, we tested the hypothesis in septic patients that this \(\it AQP5\) polymorphism is associated with major adverse kidney events and also validated its impact on 90-day survival. In this prospective observational monocentric genetic association study 282 septic patients were included and genotyped for the \(\it AQP5\) –1364A/C polymorphism (rs3759129). The primary endpoint was the development of major adverse kidney events within 30 days. In AC/CC genotypes, major adverse kidney events were less frequent (41.7%) than in AA genotypes (74.3%; OR:0.34; 95%-CI: 0.18–0.62; \(\it p\) < 0.001). Ninety-day survival was also associated with the \(\it AQP5\) polymorphism (\(\it p\) = 0.004), with 94/167 deaths (56.3%) in AA genotypes, but only 46/115 deaths (40.0%) in C-allele carriers. Multiple proportional hazard analysis revealed AC/CC genotypes to be at significantly lower risk for death within 90 days (HR: 0.60; 95%-CI: 0.42-0.86; \(\it p\) = 0.006). These findings confirm the important role of the AQP5 -1364A/C polymorphism as an independent prognostic factor in sepsis. Furthermore, we demonstrate a strong association between this \(\it AQP5\) polymorphism and susceptibility for major adverse kidney events suggesting a promising characteristic in terms of precision medicine.

Published
2020

35. Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections

Author

Rahmel, Tim (Dr. med.), Schmitz, Stefanie, Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Schepanek, Kaspar, Bergmann, Lars (Dr. med.), Halberstadt, Peter, Hörter, Stefan (Dipl.), Peters, Jürgen, and Adamzik, Michael (Prof. Dr. med.)

Abstract

Patients with severe infections and especially sepsis have a high in-hospital mortality, but even hospital survivors face long-term sequelae, decreased health-related quality of life, and high risk of death, suggesting a great need for specialized aftercare. However, data regarding a potential benefit of post-discharge rehabilitation in these patients are scarce. In this retrospective matched cohort study the claim data of a large German statutory health care insurer was analyzed. 83,974 hospital survivors having suffered from septic shock, sepsis, and severe infections within the years 2009–2016 were identified using an ICD abstraction strategy closely matched to the current Sepsis-3 definition. Cases were analyzed and compared with their matched pairs to determine their 5-year mortality and the impact of post-discharge rehabilitation. Five years after hospital discharge, mortality of initial hospital survivors were still increased after septic shock (\(HR_{adj}\) 2.03, 95%-CI 1.87 to 2.19; \(\it P\)

Published
2020

36. Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare

Author

Rahmel, Tim, Schmitz, Stefanie, Nowak, Hartmuth, Schepanek, Kaspar, Bergmann, Lars, Halberstadt, Peter, Hörter, Stefan, Peters, Jürgen, and Adamzik, Michael

Subjects
Male, Patients, Pulmonology, Science, Urology, Medizin, Aftercare, Pathology and Laboratory Medicine, Communicable Diseases, Rehabilitation Medicine, Signs and Symptoms, Diagnostic Medicine, Sepsis, Medicine and Health Sciences, Humans, Hospital Mortality, Survivors, Aged, Retrospective Studies, Shock, Septic, Hospitals, Patient Discharge, Health Care, Intensive Care Units, Severe Sepsis, Health Care Facilities, Urinary Tract Infections, Respiratory Infections, Quality of Life, Medicine, Female, Research Article
Abstract

Patients with severe infections and especially sepsis have a high in-hospital mortality, but even hospital survivors face long-term sequelae, decreased health-related quality of life, and high risk of death, suggesting a great need for specialized aftercare. However, data regarding a potential benefit of post-discharge rehabilitation in these patients are scarce. In this retrospective matched cohort study the claim data of a large German statutory health care insurer was analyzed. 83,974 hospital survivors having suffered from septic shock, sepsis, and severe infections within the years 2009–2016 were identified using an ICD abstraction strategy closely matched to the current Sepsis-3 definition. Cases were analyzed and compared with their matched pairs to determine their 5-year mortality and the impact of post-discharge rehabilitation. Five years after hospital discharge, mortality of initial hospital survivors were still increased after septic shock (HRₐdj 2.03, 95%-CI 1.87 to 2.19; P

Published
2020

37. The NFKB1 Promoter Polymorphism (-94ins/delATTG) Is Associated with Susceptibility to Cytomegalovirus Infection after Kidney Transplantation and Should Have Implications on CMV Prophylaxis Regimens

Author

Nowak, Hartmuth, primary, Vornweg, Svenja, additional, Rump, Katharina, additional, Rahmel, Tim, additional, Unterberg, Matthias, additional, Koos, Björn, additional, Schenker, Peter, additional, Viebahn, Richard, additional, Adamzik, Michael, additional, and Bergmann, Lars, additional

Published
2021
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38. Detection of Borrelia burgdorferi DNA in urine of patients with ocular Lyme borreliosis

Author

Pleyer, Uwe, Priem, Susanne, Bergmann, Lars, Burmester, Gerd, Hartmann, Christian, and Krause, Andreas

Subjects
Uveitis -- Physiological aspects -- Diagnosis, Lyme disease -- Diagnosis, Polymerase chain reaction -- Physiological aspects, Health
Abstract

Abstract Aim--To evaluate the diagnostic value of the polymerase chain reaction (PCR) to detect Borrelia burgdorferi DNA in patients with ocular Lyme borreliosis. Methods--Of 256 consecutive uveitis patients six selected [...]

Published
2001

39. Application of the ‘5-2-1’ screening criteria in advanced Parkinson’s disease: interim analysis of DUOGLOBE

Author

Aldred, Jason, primary, Anca-Herschkovitsch, Marieta, additional, Antonini, Angelo, additional, Bajenaru, Ovidiu, additional, Bergmann, Lars, additional, Bourgeois, Paul, additional, Cubo, Esther, additional, Davis, Thomas L, additional, Iansek, Robert, additional, Kovács, Norbert, additional, Kukreja, Pavnit, additional, Onuk, Koray, additional, Pontieri, Francesco E, additional, Robieson, Weining, additional, Siddiqui, Mustafa S, additional, Simu, Mihaela, additional, Standaert, David G, additional, and Chaudhuri, K Ray, additional

Published
2020
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41. The Aquaporin 3 Promoter Polymorphism −1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration

Author

Rump, Katharina, primary, Rahmel, Tim, additional, Rustige, Anna-Maria, additional, Unterberg, Matthias, additional, Nowak, Hartmuth, additional, Koos, Björn, additional, Schenker, Peter, additional, Viebahn, Richard, additional, Adamzik, Michael, additional, and Bergmann, Lars, additional

Published
2020
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46. DNA methylation of a NF-\(\kappa\)B binding site in the aquaporin 5 promoter impacts on mortality in sepsis

Author

Rump, Katharina (Dr. rer. nat.), Unterberg, Matthias, Dahlke, Agnes Maria, Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Koos, Björn, Bergmann, Lars (Dr. med.), Siffert, Winfried (Prof. Dr. med.), Schäfer, Simon Thomas (Dr. med.), Peters, Jürgen, Adamzik, Michael (Prof. Dr. med.), and Rahmel, Tim (Dr. med.)

Subjects
ddc:610
Abstract

Altered aquaporin 5 (\(\it AQP5\)) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic regulation via DNA methylation might contribute to a differential \(\it AQP5\) expression in sepsis, we tested the hypotheses that DNA methylation of the \(\it AQP5\) promotor (1) influences \(\it AQP5\) expression, (2) is associated with the 30-day survival of septic patients, and (3) alters the nuclear transcription factor NF-\(\kappa\)B binding. \(\it AQP5\) mRNA expression was quantified by real-time PCR in whole blood samples of 135 septic patients. \(\textit {In silico}\) computer analysis of the \(\it AQP5\) promoter (nt-567 to nt-975) revealed seven putative inflammatory transcription factor binding sites and methylation of these sites was analyzed. Electrophoretic mobility shift assays were performed to assess the binding of nuclear NF-\(\kappa\)B to the \(\it AQP5\) promoter region nt-937. After adjustment for multiple testing, a greater methylation rate was found at cytosine site nt-937 in the \(\it AQP5\) promoter linked to NF-\(\kappa\)B binding in non-survivors compared to survivors (p = 0.002, p\(_{adj}\) = 0.014). This was associated with greater \(\it AQP5\) mRNA expression in non-survivors (p = 0.037). Greater (\(\geq\)16%) promoter methylation at nt-937 was also associated with an independently increased risk of death within 30 days (HR: 3.31; 95% CI: 1.54–6.23; p = 0.002). We detected a functionally important \(\it AQP5\) promoter cytosine site (nt-937) linked to the binding of the inflammatorily acting nuclear transcription factor NF-\(\kappa\)B, with increased methylation in sepsis non-survivors. Thus, nt-937 \(\it AQP5\) promoter methylation, presumably related to NF-\(\kappa\)B binding, is prognostically relevant in sepsis and demonstrates that epigenetic changes impact on sepsis outcome.

Published
2019

47. The aquaporin 5 −1364A/C promoter polymorphism is associated with cytomegalovirus infection risk in kidney transplant recipients

Author

Rahmel, Tim (Dr. med.), Nowak, Hartmuth Sebastian Burkhard (Dr. med.), Frisenda, Sandra (Dr. med.), Rump, Katharina (Dr. rer. nat.), Koos, Björn, Schenker, Peter (Prof. Dr. med.), Viebahn, Richard (Prof. Dr. med.), Adamzik, Michael (Prof. Dr. med.), and Bergmann, Lars (Dr. med.)

Subjects
ddc:610
Abstract

\(\bf Background:\) The aquaporin 5 (AQP5) −1364A/C promoter single nucleotide polymorphism affects key mechanisms of inflammation and immune cell migration. Thus, it could be involved in the pathogenesis of cytomegalovirus infection. Accordingly, we tested the hypothesis that the AQP5 promoter −1364A/C polymorphism is associated with the risk of cytomegalovirus infection in kidney transplantation recipients. \(\bf Methods:\) We included 259 adult patients who received a kidney transplant from 2007 and 2014 in this observational study. Patients were genotyped for the AQP5 promoter −1364A/C single nucleotide polymorphism and followed up for 12 months after transplantation. Kaplan–Meier plots and multivariable proportional hazard analyses were used to evaluate the relationship between genotypes and the incidence of cytomegalovirus infection. \(\bf Results:\) The incidences of cytomegalovirus infection within 12 months after kidney transplantation were 22.9% for the AA genotypes (43/188) and 42.3% for the AC/CC genotypes (30/71; p = 0.002). Furthermore, multivariable COX regression revealed the C-allele of the AQP5 −1364A/C polymorphism to be a strong and independent risk factor for cytomegalovirus infection. In this analysis, AC/CC subjects demonstrated a more than 2-fold increased risk for cytomegalovirus infection within the first year after kidney transplantation (hazard ratio: 2.28; 95% CI: 1.40–3.73; p = 0.001) compared to that in individuals with homozygous AA genotypes. \(\bf Conclusions:\) With respect to opportunistic cytomegalovirus infections (attributable to immunosuppression after kidney transplantation), the C-allele of the AQP5 −1364A/C promoter polymorphism is independently associated with an increased 12-months infection risk. These findings emphasize the importance of genetic variations as additional risk factors of cytomegalovirus infection after solid organ transplantations and might also facilitate the discovery of novel therapeutic targets.

Published
2019

48. A novel understanding of postoperative complications

Author

Holtkamp, Caroline, Koos, Björn, Unterberg, Matthias, Rahmel, Tim (Dr. med.), Bergmann, Lars (Dr. med.), Bazzi, Zainab, Bazzi, Maha, Bukhari, Hassan, Adamzik, Michael (Prof. Dr. med.), and Rump, Katharina (Dr. rer. nat.)

Subjects
ddc:610
Abstract

\(\bf Background\) Propofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile. However, propofol could have long term effects on neuronal cells and is associated with post-operative delirium (POD). In this context, one of the contributing factors to the pathogenesis of POD is a reduction of cholinesterase activity. Accordingly, we investigated the effects of propofol on the methylation, expression and activity of cholinergic genes and proteins in an \(\it in-vitro\) model. \(\bf Results\) We found that propofol indeed reduced the activity of AChE / BChE in our \(\it in-vitro\) model, without affecting the protein levels. Furthermore, we could show that propofol reduced the methylation of a repressor region of the CHRNA7 gene without changing the secretion of pro–or anti-inflammatory cytokines. Lastly, propofol changed the expression patterns of genes responsible for maintaining the epigenetic status of the cell and accordingly reduced the tri-methylation of H3 K27. \(\bf Conclusion\) In conclusion we found a possible functional link between propofol treatment and POD, due to a reduced cholinergic activity. In addition to this, propofol changed the expression of different maintenance genes of the epigenome that also affected histone methylation. Thus, propofol treatment may also induce strong, long lasting changes in the brain by potentially altering the epigenetic landscape.

Published
2019

49. A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes

Author

Holtkamp, Caroline, Koos, Björn, Unterberg, Matthias, Rahmel, Tim, Bergmann, Lars, Bazzi, Zainab, Bazzi, Maha, Bukhari, Hassan, Adamzik, Michael, and Rump, Katharina

Subjects
Physiology, Cholinergic Agents, Biochemistry, Epigenesis, Genetic, Histones, Postoperative Complications, Immune Physiology, Medicine and Health Sciences, Cholinesterases, Postoperative Period, Propofol, Innate Immune System, DNA methylation, Chemical Reactions, Neurochemistry, Neurotransmitters, Chromatin, Cholinergic Neurons, Nucleic acids, Chemistry, Physical Sciences, Cytokines, Medicine, Epigenetics, DNA modification, Chromatin modification, Research Article, Chromosome biology, Methyl Ethers, Cell biology, Science, Cholinergics, Immunology, Methylation, Promoter Regions, Cell Line, Tumor, DNA-binding proteins, Genetics, Humans, Gene Regulation, Biology and life sciences, Proteins, Delirium, DNA, Molecular Development, Immune System, Gene expression, Neuroscience, Developmental Biology
Abstract

BackgroundPropofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile. However, propofol could have long term effects on neuronal cells and is associated with post-operative delirium (POD). In this context, one of the contributing factors to the pathogenesis of POD is a reduction of cholinesterase activity. Accordingly, we investigated the effects of propofol on the methylation, expression and activity of cholinergic genes and proteins in an in-vitro model.ResultsWe found that propofol indeed reduced the activity of AChE / BChE in our in-vitro model, without affecting the protein levels. Furthermore, we could show that propofol reduced the methylation of a repressor region of the CHRNA7 gene without changing the secretion of pro-or anti-inflammatory cytokines. Lastly, propofol changed the expression patterns of genes responsible for maintaining the epigenetic status of the cell and accordingly reduced the tri-methylation of H3 K27.ConclusionIn conclusion we found a possible functional link between propofol treatment and POD, due to a reduced cholinergic activity. In addition to this, propofol changed the expression of different maintenance genes of the epigenome that also affected histone methylation. Thus, propofol treatment may also induce strong, long lasting changes in the brain by potentially altering the epigenetic landscape.

Published
2019

50. Additional file 1 of Characterizing advanced Parkinson’s disease: OBSERVE-PD observational study results of 2615 patients

Author

Fasano, Alfonso, Fung, Victor, Lopiano, Leonardo, Bulent Elibol, Smolentseva, Irina, Seppi, Klaus, Takáts, Annamária, Onuk, Koray, Parra, Juan, Bergmann, Lars, Sail, Kavita, Yash Jalundhwala, and Pirtosek, Zvezdan

Subjects
musculoskeletal, neural, and ocular physiology, cardiovascular system, musculoskeletal system, circulatory and respiratory physiology
Abstract

Table S1. Types of current Parkinson’s disease treatment. Table S2. Sensitivity analysis of correlations between physician’s judgment of APD and individual Delphi criteria for APD (ongoing DAT patients excluded). Table S3. Association between physician’s judgment of APD and individual prognostic parameters. (PDF 57 kb)

Published
2019
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