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1. Factors associated with failed epidural blood patch after accidental dural puncture in obstetrics: a prospective, multicentre, international cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean., Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Mercier, Frederic, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen, Truong Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Stamelos, Mattheios, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manuel, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintaric, Tatjana, Chiquito, Teresa, Monedero, Pablo, De Carlos-Errea, Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Jörnvall, Henrik, Nordström, Johan, Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Daamen, Sylvia, Farsi, Slama, Feijten, Prisca, Harlet, Pierre, Leva, Brigitte, Plichon, Benoît, Magnuson, Anders, Guasch, Emilia, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2022
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3. Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry.

Author

Kaufmann, Elisabeth, Peltola, Jukka, Colon, Albert J., Lehtimäki, Kai, Majtanik, Milan, Mai, Jürgen K., Bóné, Beata, Bentes, Carla, Coenen, Volker, Gil‐Nagel, Antonio, Goncalves‐Ferreira, Antonio J., Ryvlin, Philippe, Taylor, Rod, Brionne, Thomas C., Gielen, Frans, Song, Shannon, and Boon, Paul

Subjects
DEEP brain stimulation, PARTIAL epilepsy, EPILEPSY surgery, NEURAL stimulation, EPILEPSY, BRAIN stimulation, TEMPORAL lobectomy
Abstract

Objective: Short‐term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT‐DBS) were reported for people with drug‐resistant focal epilepsy (PwE). Because long‐term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT‐DBS. Methods: In this multicenter registry, PwE with ANT‐DBS were followed up for safety, efficacy, and battery longevity. Follow‐up ended after 5 years or upon study closure. Clinical characteristics and stimulation settings were compared between PwE with no benefit, improvers, and responders, that is, PwE with average monthly seizure frequency reduction rates of ≥50%. Results: Of 170 eligible PwE, 104, 62, and 49 completed the 3‐, 4‐, and 5‐year follow‐up, respectively. Most discontinuations (68%) were due to planned study closure as follow‐up beyond 2 years was optional. The 5‐year follow‐up cohort had a median seizure frequency reduction from 16 per month at baseline to 7.9 per month at 5‐year follow‐up (p <.001), with most‐pronounced effects on focal‐to‐bilateral tonic–clonic seizures (n = 15, 77% reduction, p =.008). At last follow‐up (median 3.5 years), 41% (69/170) of PwE were responders. Unifocal epilepsy (p =.035) and a negative history of epilepsy surgery (p =.002) were associated with larger average monthly seizure frequency reductions. Stimulation settings did not differ between response groups. In 179 implanted PwE, DBS‐related adverse events (AEs, n = 225) and serious AEs (n = 75) included deterioration in epilepsy or seizure frequency/severity/type (33; 14 serious), memory/cognitive impairment (29; 3 serious), and depression (13; 4 serious). Five deaths occurred (none were ANT‐DBS related). Most AEs (76.3%) manifested within the first 2 years after implantation. Activa PC depletion (n = 37) occurred on average after 45 months. Significance: MORE provides further evidence for the long‐term application of ANT‐DBS in clinical routine practice. Although clinical benefits increased over time, side effects occurred mainly during the first 2 years. Identified outcome modifiers can help inform PwE selection and management. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Molecular characterization of the circadian clock in patients with Parkinson's disease–CLOCK4PD Study protocol.

Author

Yalçin, Müge, Peralta, Ana Rita, Bentes, Carla, Silva, Cristiana, Guerreiro, Tiago, Ferreira, Joaquim J., and Relógio, Angela

Subjects
CIRCADIAN rhythms, PARKINSON'S disease, RESEARCH protocols, SLEEP, SLEEP interruptions, SEX (Biology), GENE expression profiling, DEEP brain stimulation
Abstract

Introduction: Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism's physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alterations at the molecular expression level for core-clock and clock-controlled genes in PD is still missing. Methods and analysis: The proposed study protocol will be used to characterize expression profiles of circadian genes obtained from saliva samples in PD patients and controls. For this purpose, 20 healthy controls and 70 PD patients will be recruited. Data from clinical assessment, questionnaires, actigraphy tracking and polysomnography will be collected and clinical evaluations will be repeated as a follow-up in one-year time. We plan to carry out sub-group analyses considering several clinical factors (e.g., biological sex, treatment dosages, or fluctuation of symptoms), and to correlate reflected changes in CR of measured genes with distinct PD phenotypes (diffuse malignant and mild/motor-predominant). Additionally, using NanoStringⓇ multiplex technology on a subset of samples, we aim to further explore potential CR alterations in hundreds of genes involved in neuropathology pathways. Discussion: CLOCK4PD is a mono-centric, non-interventional observational study aiming at the molecular characterization of CR alterations in PD. We further plan to determine physiological modifications in sleep and activity patterns, and clinical factors correlating with the observed CR changes. Our study may provide valuable insights into the intricate interplay between CR and PD with a potential to be used as a predictor of circadian alterations reflecting distinct disease phenotypes, symptoms, and progression outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean, Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Soued, Mickaël, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen Troung, Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Tsaroucha, Athanasia, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Morina, Qamile, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., Van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyaba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Tavares, Francisca, Vasconcelos, Pedro, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manue, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintraic, Tatjana, Chiquito, Teresa, Monedero, Pablo, Carlos-Errea, De Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Cendaña, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Nordstöm, Johan L., Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Magnuson, Anders, Fernando, Roshan, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2020
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11. Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate

Author

Koepp, Matthias J., primary, Trinka, Eugen, additional, Mah, Yee‐Haur, additional, Bentes, Carla, additional, Knake, Susanne, additional, Gigli, Gian Luigi, additional, Serratosa, José M., additional, Zelano, Johan, additional, Magalhães, Luís M., additional, Pereira, Ana, additional, Moreira, Joana, additional, and Soares‐da‐Silva, Patrício, additional

Published
2023
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12. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, Colon, Albert J., Pimentel, José, Coenen, Volker A., Gil-Nagel, Antonio, Gonçalves Ferreira, António, Lehtimäki, Kai, Ryvlin, Philippe, Taylor, Rod S., Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla, Bosak, Magdalena, Burneo, Jorge G., Chamadoira, Clara, Elger, Christian E., Erőss, Loránd, Fabo, Dániel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Järvenpää, Soila, Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew, Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana, Rácz, Attila, Rainha Campos, Alexandre, Rego, Ricardo, Ricciuti, Riccardo A., Rona, Sabine, Rouhl, Rob P.W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack, Abouihia, Abdallah, Brionne, Thomas C., Gielen, Frans, Boon, Paul A.J.M., Tampere University, Clinical Medicine, Department of Neurosciences and Rehabilitation, and Repositório da Universidade de Lisboa

Subjects
Medicine and Health Sciences, Neurology (clinical), 3124 Neurology and psychiatry
Abstract

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation. Classification of evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., The MORE registry was sponsored and funded by Medtronic, plc.

Published
2023

15. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Author

Ferreira-Atuesta, Carolina, primary, de Tisi, Jane, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, Khoury, Jean, additional, Yardi, Ruta, additional, Vegh, Deborah T, additional, Butler, James, additional, Lee, Hamin J, additional, Deli-Peri, Victoria, additional, Yao, Yi, additional, Wang, Feng-Peng, additional, Zhang, Xiao-Bin, additional, Shakhatreh, Lubna, additional, Siriratnam, Pakeeran, additional, Neal, Andrew, additional, Sen, Arjune, additional, Tristram, Maggie, additional, Varghese, Elizabeth, additional, Biney, Wendy, additional, Gray, William P, additional, Peralta, Ana Rita, additional, Rainha-Campos, Alexandre, additional, Gonçalves-Ferreira, António J C, additional, Pimentel, José, additional, Arias, Juan Fernando, additional, Terman, Samuel, additional, Terziev, Robert, additional, Lamberink, Herm J, additional, Braun, Kees P J, additional, Otte, Willem M, additional, Rugg-Gunn, Fergus J, additional, Gonzalez, Walter, additional, Bentes, Carla, additional, Hamandi, Khalid, additional, O'Brien, Terence J, additional, Perucca, Piero, additional, Yao, Chen, additional, Burman, Richard J, additional, Jehi, Lara, additional, Duncan, John S, additional, Sander, Josemir W, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2022
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18. Sleep and awakening quality during COVID-19 confinement

Author

Paiva, Teresa, Reis, Cátia, Feliciano, Amélia, Canas-Simião, Hugo, Machado, Maria Augusta, Gaspar, Tânia, Tomé, Gina, Branquinho, Cátia, Silva, Maria Raquel, Ramiro, Lúcia, Gaspar, Susana, Bentes, Carla, Sampaio, Francisco, Pinho, Lara, Pereira, Conceição, Carreiro, Alexandra, Moreira, Susana, Luzeiro, Isabel, Pimentel, Joana, Videira, Gabriela, Fonseca, Júlio, Bernarda, Ana, Castro, Joana Vaz, Rebocho, Sofia, Almondes, Katie, Canhão, Helena, Matos, Margarida Gaspar, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Health-related behaviors, SDG 3 - Good Health and Well-being, Health, Attitudes, Health, Toxicology and Mutagenesis, Mood, Public Health, Environmental and Occupational Health, COVID-19, Dependences, Health professionals, Sleep patients, Sleep/awakening quality, Calamity Experience Check List
Abstract

Acknowledgments: Gina Tomé is a postdoctorate funded by the Fundação Ciência e Tecnologia (FCT) SFRH/BPD/108637/2015. Objective: The aim of this study was to evaluate sleep and awakening quality (SQ and AQ) during COVID-19 in a large and diversified population in order to identify significant associations and risks in terms of demography, health and health-related behaviors, sleep variables, mental health, and attitudes. Methods/Results:Online surveys were used for data collection, received from 5479 individuals from the general population, sleep disorder patients, and COVID-involved (medical doctors (MDs) and nurses) and COVID-affected professionals (teachers, psychologists, and dentists). SQ and AQ were worse in adults, females, and high-education subjects. Feeling worse, having economic problems, depression, anxiety, irritability, and a high Calamity Experience Check List (CECL) score during COVID were significantly associated with poor SQ and AQ. Shorter sleep duration, increased latency, poor nutrition, low physical activity, increased mobile and social network use, more negative and less positive attitudes and behaviors were associated with poor AQ. Conclusions: The SQ logistic regression showed gender, morbidities, CECL, and awakenings as relevant, whereas, for AQ, relevant variables further included age and physical activity. Aiming to have a high stress compliance, each individual should sleep well, have important control of their mood, practice positive behaviors while dismissing negative behaviors and attitudes, practice exercise, have adequate nutrition, and beware of technologies and dependences. publishersversion published

Published
2021

20. a challenging semiology

Author

Leal Rato, Miguel, Ionel, Cristina, Baduro, Yanina, Oliveira, Renato, Franco, Ana Catarina, Peralta, Ana Rita, Bentes, Carla, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Neurology, Clinical Neurology
Abstract

publishersversion published

Published
2020

21. Sleep and Awakening Quality during COVID-19 Confinement: Complexity and Relevance for Health and Behavior

Author

Paiva, Teresa, primary, Reis, Cátia, additional, Feliciano, Amélia, additional, Canas-Simião, Hugo, additional, Machado, Maria Augusta, additional, Gaspar, Tânia, additional, Tomé, Gina, additional, Branquinho, Cátia, additional, Silva, Maria Raquel, additional, Ramiro, Lúcia, additional, Gaspar, Susana, additional, Bentes, Carla, additional, Sampaio, Francisco, additional, Pinho, Lara, additional, Pereira, Conceição, additional, Carreiro, Alexandra, additional, Moreira, Susana, additional, Luzeiro, Isabel, additional, Pimentel, Joana, additional, Videira, Gabriela, additional, Fonseca, Júlio, additional, Bernarda, Ana, additional, Vaz Castro, Joana, additional, Rebocho, Sofia, additional, Almondes, Katie, additional, Canhão, Helena, additional, and Matos, Margarida Gaspar, additional

Published
2021
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22. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Gupta, Anil, primary, von Heymann, Christian, additional, Magnuson, Anders, additional, Alahuhta, Seppo, additional, Fernando, Roshan, additional, Van de Velde, Marc, additional, Mercier, Frédéric J., additional, Schyns-van den Berg, Alexandra M.J.V., additional, Casier, Isabelle, additional, Bryon, Bart, additional, Soetens, Filiep, additional, Dewandre, Pierre-Yves, additional, Lambert, Geraldine, additional, Christiaen, Jan, additional, Schepers, Roel, additional, Van Houwe, Patrick, additional, Kalmar, Alain, additional, Vanoverschelde, Henk, additional, Bauters, Monique, additional, Roofthooft, Eva, additional, Devroe, Sarah, additional, Jadrijevic, Ana, additional, Jokic, Aleksandra, additional, Marin, Damjan, additional, Sklebar, Ivan, additional, Mihaljević, Slobodan, additional, Kosinova, Martina, additional, Stourac, Petr, additional, Adamus, Milan, additional, Kufa, Christian, additional, Volfová, Ivana, additional, Zaoralová, Blažena, additional, Froeslev-Friis, Christina, additional, Mygil, Bjoern, additional, Krebs Albrechtsen, Charlotte, additional, Kavasmaa, Tomi, additional, Mäyrä, Anne, additional, Mennander, Susanna, additional, Rautaneva, Kati, additional, Hiekkanen, Tuula, additional, Kontinen, Vesa, additional, Linden, Kirsti, additional, Toivakka, Sara, additional, Boselli, Emmanuel, additional, Greil, Pierre-Édouard, additional, Mascle, Olivier, additional, Courbon, Aurelie, additional, Lutz, Jean, additional, Simonet, Thérèse, additional, Barbier, Marie, additional, Hlioua, Tarik, additional, Meniolle d’Hauthville, Fleur, additional, Quintin, Christine, additional, Bouattour, Karim, additional, Lecinq, Agnès, additional, Soued, Mickaël, additional, Bonnet, Marie-Pierre, additional, Carbonniere, Mathieu, additional, Fischer, Catherine, additional, Picard, Paola-Carla, additional, Bonnin, Martine, additional, Storme, Brigitte, additional, Bouthors, Anne-Sophie, additional, Detente, Thomas, additional, Nguyen Troung, Minh, additional, Keita, Hawa, additional, Nebout, Sophie, additional, Osse, Lauranne, additional, Delmas, Anne, additional, Vial, Florence, additional, Kaufner, Lutz, additional, Hoefing, Christoph, additional, Mueller, Stefan, additional, Becke, Karin, additional, Blobner, Manfred, additional, Lewald, Heidrun, additional, Schaller, Stefan Josef, additional, Muggleton, Ellis, additional, Bette, Birgit, additional, Neumann, Claudia, additional, Weber, Stefan, additional, Grünewald, Matthias, additional, Ohnesorge, Henning, additional, Helf, Antonia, additional, Jelting, Yvonne, additional, Kranke, Peter, additional, Welfle, Sabine, additional, Staikou, Chryssoula, additional, Stavrianopoulou, Antonia, additional, Tsaroucha, Athanasia, additional, Kalopita, Konstantina, additional, Loukeri, Anastasia, additional, Valsamidis, Dimitrios, additional, Matsota, Paraskevi, additional, Thorsteinsson, Adalbjörn, additional, Tome, Riad, additional, Eidelman, Leonid A., additional, Davis, Atara, additional, Orbach-Zinger, Sharon, additional, Ioscovich, Alexander, additional, Ramona, Iacob, additional, De Simone, Luigi, additional, Pesetti, Barbara, additional, Brazzi, Luca, additional, Zito, Alessandro, additional, Camorcia, Michela, additional, Della Rocca, Giorgio, additional, Aversano, Marco, additional, Frigo, Maria Grazia, additional, Todde, Cristina, additional, Morina, Qamile, additional, Macas, Andrius, additional, Keraitiene, Grazina, additional, Rimaitis, Kestutis, additional, Borg, Francis, additional, Tua, Carl, additional, Kuijpers-Visser, Agnes Geertje, additional, Schyns-van den Berg, Alexandra, additional, Hollmann, Markus W., additional, Van den Berg, Tijs, additional, Koolen, Eric, additional, Dons, Ilse, additional, van der Knijff, Anouk, additional, van der Marel, Caroline, additional, Ruysschaert, Nele, additional, Pelka, Michal, additional, Pluymakers, Christine, additional, Koopman, Seppe, additional, Teunissen, Aart-Jan, additional, Cornelisse, Dick, additional, van Dasselaar, Nick, additional, Verdouw, Bastiaan, additional, Beenakkers, Ingrid, additional, Dahl, Vegard, additional, Hagen, Robert, additional, Vivaldi, Francesco, additional, Eriksen, John Reidar, additional, Wiszt, Radovan, additional, Aslam Tayyaba, Naz, additional, Ringvold, Else-Marie, additional, Chutkowski, Radosław, additional, Skirecki, Tomasz, additional, Wódarski, Bartłomiej, additional, Faria, Maria Aida, additional, Ferreira, Amélia, additional, Sampaio, Ana Catarina, additional, Ferreira, Irene, additional, Matias, Bernardo, additional, Teixeira, Joana, additional, Araujo, Rita, additional, Cabido, Herminia, additional, Fortuna, Rosario, additional, Lemos, Paulo, additional, Cardoso, Carolina, additional, Moura, Fernando, additional, Pereira, Cristiana, additional, Pereira, Sandra, additional, Tavares, Francisca, additional, Vasconcelos, Pedro, additional, Abecasis, Manuel, additional, Lança, Filipa, additional, Muchacho, Paulo, additional, Ormonde, Lucindo, additional, Guedes-Araujo, Isabel, additional, Pinho-Oliveira, Vitor, additional, Paredes, Paulo, additional, Bentes, Carla, additional, Gouveia, Francisco, additional, Milheiro, Ana, additional, Castanheira, Cláudia, additional, Neves, Miriam, additional, Pacheco, Vânia, additional, Cortez, Mara, additional, Tranquada, Raquel, additional, Tareco, Glória, additional, Furtado, Inês, additional, Pereira, Estela, additional, Marinho, Luísa, additional, Seabra, Manue, additional, Bulasevic, Aleksandra, additional, Kendrisic, Mirjana, additional, Jovanovic, Lidija, additional, Pujić, Borislava, additional, Kutlesic, Marija, additional, Grochova, Monika, additional, Simonova, Jana, additional, Pavlovic, Gordana, additional, Rozman, Ales, additional, Blajic, Iva, additional, Graovac, Dragan, additional, Stopar Pintraic, Tatjana, additional, Chiquito, Teresa, additional, Monedero, Pablo, additional, Carlos-Errea, De Joaquin, additional, Guillén-Casbas, Roque, additional, Veiga-Gil, Leonor, additional, Basso, Morena, additional, Garcia Bartolo, Carolina, additional, Hernandez, Cristian, additional, Ricol, Laura, additional, De Santos, Maroto Pinar, additional, Gràcia Solsona, Josep A., additional, López-Baamonde, Manuel, additional, Magaldi Mendaña, Marta, additional, Plaza Moral, Ana María, additional, Vendrell, Marina, additional, Trillo, Lourdes, additional, Perez Garcia, Anibal Ricardo, additional, Alamillo Salas, Clara, additional, Moret, Enric, additional, Ramió, Laura, additional, Aguilar Sanchez, Jose Luis, additional, Soler Pedrola, Maria, additional, Valldeperas Hernandez, Maria Inmaculada, additional, Aldalur, Gorka, additional, Bárcena, Estíbaliz, additional, Herrera, Julia, additional, Iturri, Fernando, additional, Martínez, Alberto, additional, Martínez, Leire, additional, Serna, Rosa, additional, Gilsanz, Fernando, additional, Guasch Arevalo, Emilia, additional, Iannuccelli, Fabrizio, additional, Latorre, Julieta, additional, Rodriguez Roca, Cristina, additional, Pérez Pardo, Osvaldo Ceferino, additional, Sierra Biddle, Natalia, additional, Suárez Cendaña, Ceferina, additional, Hernández González, Lourdes, additional, Remacha González, Caridad, additional, Sánchez Nuez, Raquel, additional, Anta, Diego, additional, Beleña, Jose M., additional, García-Cuadrado, Carmen, additional, Garcia, Irene, additional, Manrique, Susana, additional, Suarez, Elena, additional, Hein, Anette, additional, Arbman, Elisabet, additional, Hansson, Helena, additional, Tillenius, Monika, additional, Al-Taie, Ruaa, additional, Ledin-Eriksson, Susanne, additional, Lindén-Söndersö, Anja, additional, Rosén, Ola, additional, Austruma, Evija, additional, Gillberg, Lars, additional, Darvish, Bijan, additional, Gupta, Anil, additional, Nordstöm, Johan L., additional, Persson, Jan, additional, Rosenberg, Jan, additional, Brühne, Lars, additional, Forshammar, Johan, additional, Ugarph Edfeldt, Malin, additional, Rolfsson, Håkan, additional, Hellblom, Anna, additional, Levin, Katarina, additional, Rabow, Sofus, additional, Thorlacius, Karin, additional, Bansch, Peter, additional, Robertson (Baeriswyl), Moira, additional, Stamer, Ulrike, additional, Mathivon, Stanislas, additional, Savoldelli, Georges, additional, Auf der Maur, Pia, additional, Filipovic, Miodrag, additional, Dullenkopf, Alexander, additional, Brunner, Maya, additional, Girard, Thierry, additional, Vonlanthen, Claudia, additional, Ozbilgin, Sule, additional, Gunaydin D, Berrin, additional, Corman Dincer, Pelin, additional, and Tas Tuna, Ayca, additional

Published
2020
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24. Clinical course and variability of non-Rasmussen, nonstroke motor and sensory epilepsia partialis continua: A European survey and analysis of 65 cases

Author

Mameniskiene, Ruta, Bast, Thomas, Bentes, Carla, Canevini, Maria P., Dimova, Petia, Granata, Tiziana, Hgenhaven, Hans, Jakubi, Bosanka Jocic, Marusic, Petr, Melikyan, Gayane, Michelucci, Roberto, Mukhin, Konstantin Y., Oehl, Bernhard, Ragona, Francesca, Rossetti, Andrea O., Rubboli, Guido, Schubert, Susanne, Stephani, Ulrich, Strobel, Julia, Vignoli, Aglaia, Zarubova, Jana, and Wolf, Peter

Published
2011
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25. Interrater agreement of classification of photoparoxysmal electroencephalographic response

Author

Beniczky, Sándor, primary, Aurlien, Harald, additional, Franceschetti, Silvana, additional, Martins da Silva, Antonio, additional, Bisulli, Francesca, additional, Bentes, Carla, additional, Canafoglia, Laura, additional, Ferri, Lorenzo, additional, Krýsl, David, additional, Rita Peralta, Ana, additional, Rácz, Attila, additional, Cross, J. Helen, additional, and Arzimanoglou, Alexis, additional

Published
2020
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26. INTRAOPERATIVE ANTICOAGULATION MONITORIZATION IN VASCULAR SURGERY ��� DOES A BLIND DOSIS FITS ALL?

Author

Coelho, Nuno Henriques, Pontes, Raquel Laranja, Silva, Rita, Martins, Victor, Oliveira, Cármen, Campos, Jacinta, Sousa, Pedro, Coelho, Andreia, Augusto, Rita, Semião, Carolina, Pinto, Evelise, Ribeiro, João, Canedo, Alexandra, and Bentes, Carla

Subjects
Vascular surgery, Unfractionated heparin, Heparina não fracionada, Activated clotting time, Heparinization monitoring, Anticoagulation monitorization, Cirurgia vascular, Monitorização intraoperatória da anticoagulação
Abstract

Introduction: Unfractionated heparin (UFH) has been used for decades to prevent thrombotic events during vascular surgery. Although it is known that UFH has a complex and nonlinear pharmacokinetics, with great individual variability, anticoagulation monitorization in vascular surgery is not routine and a standard empirical dose is often used. Activated clotting time (ACT) has been shown to be a simple, reliable and inexpensive way to monitor UFH anticoagulant effect, being routinely used during cardiac surgery. However, heparinisation remains a dilemma in vascular surgery and few studies emphasized the role of anticoagulation monitoring in this setting. Objectives: To investigate whether a fixed heparin dose of 5000 IU in arterial vascular surgery results in adequate and homogeneous heparinisation in all patients. Secondary endpoints: to identify preoperative factors for heparin response, intraoperative events and outcomes. Methods: This observational prospective pilot study included 30 consecutive patients undergoing arterial vascular surgery. ACT monitoring was performed before clamping and at 3, 30 and 60 minutes after 5000 IU UFH bolus. Preoperative and intraoperative data were also accessed. A target ACT of ��� 200 s was set, taking in account of the lowest ACT value admitted by vascular surgery recommendations. Results: The average ACT value increased to 210.20 �� 28.82 s (1.61 �� 0.25 times vs baseline) 3 minutes after bolus, then declined to 191.60 �� 21.86 s and 173.4 �� 21.37 s after 30 and 60 minutes, respectively. Three minutes after UFH bolus, 53% patients had ACT ��� 200 s, decreasing to one third and 7% at 30 and 60 minutes, respectively. Even when weight-based, a correlation between heparin dose per kilogram and ACT change was not found (r = 0.187; p = 0.322). There was also no correlation between ACT values and preoperative hemoglobin, platelet count, creatinine clearance or INR. There was a positive correlation between preoperative aPTT and intraoperative ACT measurements (r = 0.432; p = 0.017). There was no difference between ACT values and previous antithrombotic/anticoagulant therapy and between intraoperative ACT and intraoperative blood loss. Conclusions: This study confirms that administrating a fixed or even a weight-based heparinisation is insufficient to provide consistent anticoagulation levels in all patients. Perioperative anticoagulation should be monitored and ACT-based. Larger clinical RCT's are warranted., Angiologia e Cirurgia Vascular, Vol 14 No 4 (2018): December

Published
2019
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27. The EEG in acute ischaemic cerebrovascular disease

Author

Bentes, Carla Cristina Paulo Gabriel, Ferro, José Manuel Morão Cabral, and Paiva, Maria Teresa de Aguiar dos Santos

Subjects
Epilepsy, Ciências Médicas::Medicina Clínica [Domínio/Área Científica], Alteplase, EEG, Transient ischaemic attacks, Cerebrovascular disease, Teses de doutoramento - 2018, Ischaemic stroke, Intravenous thrombolysis, Acute symptomatic seizures
Abstract

Submitted by Paula Guerreiro (passarinho@reitoria.ulisboa.pt) on 2019-04-24T09:31:28Z No. of bitstreams: 1 ULSD7328948_td_Carla_Bentes.pdf: 36684370 bytes, checksum: fe0111442d8fff5a08d66e12df78c4a6 (MD5) Made available in DSpace on 2019-05-06T09:09:06Z (GMT). No. of bitstreams: 1 ULSD7328948_td_Carla_Bentes.pdf: 36684370 bytes, checksum: fe0111442d8fff5a08d66e12df78c4a6 (MD5) Previous issue date: 2018

Published
2018

32. Early EEG predicts poststroke epilepsy

Author

Bentes, Carla, primary, Martins, Hugo, additional, Peralta, Ana Rita, additional, Morgado, Carlos, additional, Casimiro, Carlos, additional, Franco, Ana Catarina, additional, Fonseca, Ana Catarina, additional, Geraldes, Ruth, additional, Canhão, Patrícia, additional, Pinho e Melo, Teresa, additional, Paiva, Teresa, additional, and Ferro, José M., additional

Published
2018
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34. Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients

Author

Bentes, Carla, primary, Peralta, Ana Rita, additional, Martins, Hugo, additional, Casimiro, Carlos, additional, Morgado, Carlos, additional, Franco, Ana Catarina, additional, Viana, Pedro, additional, Fonseca, Ana Catarina, additional, Geraldes, Ruth, additional, Canhão, Patrícia, additional, Pinho e Melo, Teresa, additional, Paiva, Teresa, additional, and Ferro, José M., additional

Published
2017
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39. Sleep-related eating disorder secondary to zolpidem.

Author

Nzwalo, Hipólito, Ferreira, Ligia, Peralta, Rita, and Bentes, Carla

Subjects
DIAGNOSIS of eating disorders, SLEEP disorder diagnosis, DIFFERENTIAL diagnosis, EATING disorders, INGESTION, SLEEP, SLEEP disorders, ZOLPIDEM
Abstract

Sleep-related eating disorder (SRED) is characterised by eating episodes during the first period of the night sleep with partial loss consciousness, and amnesia. It can rarely be induced by some drugs, including zolpidem. We present a video report of a patient with a 1-year history of SRED caused by zolpidem causing important repercussions in the sleep structure and life quality. The night eating episodes ceased promptly with discontinuation of zolpidem. Upon the follow-up, the sleep structure improved and the daily consequences disappeared. As in few reported cases of zolpidem-induced SRED, our patient was suffering from the parasomnia for a long time before the diagnosis. Active exclusion of symptoms suggestive of SRED in patients under zolpidem treatment can avoid the deleterious effect of the sleep disorder. [ABSTRACT FROM AUTHOR]

Published
2013
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40. EEG as a prognostic tool after cardiac arrest

Author

Guedes, Beatriz Faustino, Bentes, Carla, and Manita, Manuel

Subjects
Padrões malignos, Prognóstico, Padrões benignos, Paragem cardiorespiratória, Padrões altamente malignos, Ciências Médicas [Domínio/Área Científica], EEG, Teses de mestrado - 2020
Abstract

Tese de mestrado, Neurociências, Universidade de Lisboa, Faculdade de Medicina, 2020 Submitted by Fernando João Machado (fjmachado@fm.ul.pt) on 2021-02-05T14:02:45Z No. of bitstreams: 1 12466_Tese.pdf: 2040471 bytes, checksum: 6190b30bf4d5b83b79b8236ef8399a7b (MD5) Made available in DSpace on 2021-02-05T14:02:59Z (GMT). No. of bitstreams: 1 12466_Tese.pdf: 2040471 bytes, checksum: 6190b30bf4d5b83b79b8236ef8399a7b (MD5) Previous issue date: 2020-07-20

Published
2020

41. Psychiatric disorders in drug-resistant epileptic patients submitted to DBS

Author

Nascimento, Patrícia Bidarra Figueiredo Cravo Do, Bentes, Carla, and Novais, Filipa

Subjects
Neurologia, Síndromes psiquiátricas, Núcleo anterior do tálamo-estimulação cerebral profunda, Symptom checklist-90, Ciências Médicas [Domínio/Área Científica], Sintomas psiquiátricos, Epilepsia
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020 Submitted by Sofia Amador (sofiamador@fm.ul.pt) on 2021-06-02T10:10:05Z No. of bitstreams: 1 PatriciaBNascimento.pdf: 2208346 bytes, checksum: 033622acea486b78ca12cd1533075c65 (MD5) Made available in DSpace on 2021-06-04T10:37:07Z (GMT). No. of bitstreams: 1 PatriciaBNascimento.pdf: 2208346 bytes, checksum: 033622acea486b78ca12cd1533075c65 (MD5) Previous issue date: 2020-07-17

Published
2020

42. Non REM sleep pathology in REM sleep behavior disorder : arousal analysis

Author

Miguel, Rita Cristina Alves Louro, Peralta, Ana Rita Fernandes, 1976, and Bentes, Carla Cristina Paulo Gabriel

Subjects
Sono não REM, Teses de mestrado - 2018, Microdespertar, Análise espetral, Ciências Médicas [Domínio/Área Científica], Parassónia, RBD
Abstract

Tese de mestrado, Neurociências, Universidade de Lisboa, Faculdade de Medicina, 2018 Submitted by Fernando João Machado (fjmachado@fm.ul.pt) on 2018-05-22T14:25:53Z No. of bitstreams: 1 11503_Tese.pdf: 1801606 bytes, checksum: aa2388885b408eed678ecff5238c0bc4 (MD5) Made available in DSpace on 2018-05-22T14:26:04Z (GMT). No. of bitstreams: 1 11503_Tese.pdf: 1801606 bytes, checksum: aa2388885b408eed678ecff5238c0bc4 (MD5) Previous issue date: 2017

Published
2018

43. Ocorrência circadiária de crises em doentes com epilepsia

Author

Nzwalo, Hipólito José Da Silva, Paiva, Teresa, 1945, and Bentes, Carla

Subjects
Teses de mestrado - 2016, Crises, Ciências Médicas::Ciências da Saúde [Domínio/Área Científica], Ocorrência circadiária, Epilepsia
Abstract

Tese de mestrado, Ciências do Sono, Faculdade de Medicina, Universidade de Lisboa, 2016 Submitted by Lucília Mateus (luciliamateus@fm.ul.pt) on 2016-05-16T08:41:16Z No. of bitstreams: 1 11044_Tese.pdf: 1748801 bytes, checksum: 7e3fe8617a04fab11dd35bb786abf447 (MD5) Made available in DSpace on 2016-05-16T16:03:48Z (GMT). No. of bitstreams: 1 11044_Tese.pdf: 1748801 bytes, checksum: 7e3fe8617a04fab11dd35bb786abf447 (MD5) Previous issue date: 2016

Published
2016

44. Sonolência excessiva diurna após tratamento com CPAP na síndrome da apneia obstrutiva do sono

Author

Pereira, Flávio Miguel Lourenço, Bentes, Carla, and Peralta, Ana Rita

Subjects
Síndrome da apneia obstrutiva do sono, Tratamento, Sonolência excessiva, Ciências Médicas [Domínio/Área Científica]
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014 Submitted by Biblioteca da Faculdade de Medicina da Universidade de Lisboa (repositorio@medicina.ulisboa.pt) on 2016-06-07T14:33:53Z No. of bitstreams: 1 FlavioMLPereira.pdf: 588149 bytes, checksum: 69ef3af0b09a6dec03ce175ac8552f02 (MD5) Made available in DSpace on 2016-06-07T17:30:53Z (GMT). No. of bitstreams: 1 FlavioMLPereira.pdf: 588149 bytes, checksum: 69ef3af0b09a6dec03ce175ac8552f02 (MD5) Previous issue date: 2014

Published
2014

45. Epilepsia refratária e estimulação cerebral profunda : 2 casos de heterotopia subcortical em banda

Author

Pinelo, Sara Ferreira, Bentes, Carla, and Pimentel, José

Subjects
Heterotopia subcortical em banda, Ciências Médicas [Domínio/Área Científica], Epilepsia refratária, Malformação do desenvolvimento cortical, Neuroestimulação, Estimulação cerebral profunda, Epilepsia
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014 Submitted by Biblioteca da Faculdade de Medicina da Universidade de Lisboa (repositorio@medicina.ulisboa.pt) on 2016-07-21T12:40:17Z No. of bitstreams: 1 SaraFPinelo.pdf: 648438 bytes, checksum: 5abbe1b63c93b55efb50f6550be1ba24 (MD5) Made available in DSpace on 2016-08-10T09:41:36Z (GMT). No. of bitstreams: 1 SaraFPinelo.pdf: 648438 bytes, checksum: 5abbe1b63c93b55efb50f6550be1ba24 (MD5) Previous issue date: 2014

46. Frequência de crises epiléticas em doentes submetidos a craniectomia descompressiva após AVC

Author

Fernandes, Tiago da Silveira Sampaio, Bentes, Carla, and Melo, Teresa Pinho e

Subjects
Neurologia, AVC isquémico, Ciências Médicas [Domínio/Área Científica], Hemicraniectomia descompressiva, Epilepsia
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020 Submitted by Sofia Amador (sofiamador@fm.ul.pt) on 2021-10-29T07:37:14Z No. of bitstreams: 1 TiagoSFernandes.pdf: 1104563 bytes, checksum: 564407352350aef8681297945d4e5629 (MD5) Made available in DSpace on 2021-10-29T10:12:01Z (GMT). No. of bitstreams: 1 TiagoSFernandes.pdf: 1104563 bytes, checksum: 564407352350aef8681297945d4e5629 (MD5) Previous issue date: 2020-07-17

47. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.

Author

Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, and Galovic M

Subjects
Humans, Adult, Anticonvulsants adverse effects, Neoplasm Recurrence, Local drug therapy, Seizures drug therapy, Epilepsy drug therapy, Epilepsy surgery, Epilepsy, Generalized drug therapy, Epilepsies, Partial
Abstract

More than half of adults with epilepsy undergoing resective epilepsy surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. We aimed to identify predictors of seizure recurrence after starting postoperative antiseizure medication withdrawal and develop and validate predictive models. We performed an international multicentre observational cohort study in nine tertiary epilepsy referral centres. We included 850 adults who started antiseizure medication withdrawal following resective epilepsy surgery and were free of seizures other than focal non-motor aware seizures before starting antiseizure medication withdrawal. We developed a model predicting recurrent seizures, other than focal non-motor aware seizures, using Cox proportional hazards regression in a derivation cohort (n = 231). Independent predictors of seizure recurrence, other than focal non-motor aware seizures, following the start of antiseizure medication withdrawal were focal non-motor aware seizures after surgery and before withdrawal [adjusted hazard ratio (aHR) 5.5, 95% confidence interval (CI) 2.7-11.1], history of focal to bilateral tonic-clonic seizures before surgery (aHR 1.6, 95% CI 0.9-2.8), time from surgery to the start of antiseizure medication withdrawal (aHR 0.9, 95% CI 0.8-0.9) and number of antiseizure medications at time of surgery (aHR 1.2, 95% CI 0.9-1.6). Model discrimination showed a concordance statistic of 0.67 (95% CI 0.63-0.71) in the external validation cohorts (n = 500). A secondary model predicting recurrence of any seizures (including focal non-motor aware seizures) was developed and validated in a subgroup that did not have focal non-motor aware seizures before withdrawal (n = 639), showing a concordance statistic of 0.68 (95% CI 0.64-0.72). Calibration plots indicated high agreement of predicted and observed outcomes for both models. We show that simple algorithms, available as graphical nomograms and online tools (predictepilepsy.github.io), can provide probabilities of seizure outcomes after starting postoperative antiseizure medication withdrawal. These multicentre-validated models may assist clinicians when discussing antiseizure medication withdrawal after surgery with their patients., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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48. Usefulness of EEG for the differential diagnosis of possible transient ischemic attack.

Author

Bentes C, Canhão P, Peralta AR, Viana P, Fonseca AC, Geraldes R, Pinho E Melo T, Paiva T, and Ferro JM

Abstract

Objective: EEG value in possible transient ischemic attacks (TIA) is unknown. We aim to quantify focal slow wave activity (FSWA) and epileptiform activity (EA) frequency in possible TIA, and to analyse its contribution to the final diagnosis of seizures and/or definitive TIA., Methods: Prospective longitudinal study of possible TIA patients evaluated at a tertiary centre during 36 months and with 1-3 months follow-up. EEG was performed as soon as possible (early EEG) and one month later (late EEG). A stroke neurologist established final diagnosis after reassessing all clinical and diagnostic tests., Results: 80 patients underwent an early EEG (45.8 h after possible TIA): 52 had FSWA and 6 of them also EA. Early FSWA was associated with epileptic seizure or definitive TIA final diagnosis (p = .041). Patients with these diagnoses had more frequently early FSWA (19/23; 82.6%) than EA (6/23; 26.1%). 6/13 (46.2%) patients with epileptic seizure final diagnosis had EA.In the late EEG, 43 (58.1%) patients demonstrated persistent FSWA and 3 of them also EA. Persistent FSWA in the late EEG was more frequent in seizures than in TIA patients (91.7% vs. 45.5%). FSWA disappearance was associated with acute vascular lesion on neuroimage., Conclusions: FSWA was the commonest EEG abnormality found in the early EEG of patients with possible TIA, but did not distinguish between TIA and seizure patients. In patients with seizures, FSWA was more common than EA and its presence in the late EEG was more likely in patients with epileptic seizures than with TIA., Significance: The majority of possible TIA patients with the final diagnosis of epileptic seizures do not have EA in the early or late EEG.

Published
2017
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49. [Convulsive status epilepticus. Physiopathologic and clinical features].

Author

Bentes CC and Pimentel JG

Subjects
Child, Humans, Prognosis, Status Epilepticus classification, Status Epilepticus etiology, Terminology as Topic, Status Epilepticus diagnosis, Status Epilepticus physiopathology
Abstract

Convulsive status epilepticus (CSE) is a medical emergency with a prognosis associated to its duration, aetiology and patient age. On account of the absence of a satisfactory definition and of its clinical and electroencephalographical dynamic temporal evolution, recognition of this entity is a major clinical problem. Only the early recognition of CSE allows an urgent treatment, the reason why it should be adopted the following practical definition: 5 min or more of continuous seizures or two or more seizures without regain of consciousness between them. The treatment should be immediately initiated whenever a patient has a convulsion that persists more than 5 min, has a second seizure in the posictal period, or experience a generalized tonic-clonic convulsion at the time of arrival in the emergency department. The typical temporal evolution of CSE affects its prognosis since subtil SE is more refractory to treatment than evident SE. The monitoring of any kind of treatment protocol should have not only a careful clinical observation but also an EEG continuous record.

Published
2003

50. [Convulsive status epilepticus. Therapeutic protocol].

Author

Bentes CC and Pimentel JG

Subjects
Child, Clinical Protocols, Humans, Status Epilepticus drug therapy
Abstract

Convulsive status epilepticus (CSE) in a medical emergency with a prognosis associated to its duration, claiming an early and effective treatment. The authors present the treatment protocol proposed at the Hospital de Santa Maria. The chosen definition of CSE allows its rapid treatment, and the electroencephalographic record the monitoring of its real efficacy. The treatment protocol is initiated whenever there are: continuous seizures persisting for more than 5 min, or two or more seizures surveying without regain of consciousness between them. The goal is stopping convulsive activity in less than 30 min and interrupting any epileptiform electroencephalographic activity. The initial pharmacological treatment of CSE includes lorazepam and fosphenitoin, a phenitoin prodrug. The first is chosen by the longer duration of its antiseizure effect as compared with diazepam; the second allows the administration of an identical dose but in a shorter period of time as compared to the mother drug; besides, it has few local and systemic effects and can be given intramuscularly after stopping the CSE. Drugs with a rapid clinical effect and rapid clearance, as midazolam and propofol should be used for treating refractory SE. Pentobarbital is the last anesthetic drug to be used because of its adverse cardiovascular effects and long-lasting action which can delay weaning from ventilatory support.

Published
2003

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