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1. Ferroptosis and pyroptosis signatures in critical COVID-19 patients

Author

Peleman, Cédric, Van Coillie, Samya, Ligthart, Symen, Choi, Sze Men, De Waele, Jan, Depuydt, Pieter, Benoit, Dominique, Schaubroeck, Hannah, Francque, Sven M., Dams, Karolien, Jacobs, Rita, Robert, Dominique, Roelandt, Ria, Seurinck, Ruth, Saeys, Yvan, Rajapurkar, Mohan, Jorens, Philippe G., Hoste, Eric, and Vanden Berghe, Tom

Published
2023
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4. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF)

Author

Schnell, David, Azoulay, Elie, Benoit, Dominique, Clouzeau, Benjamin, Demaret, Pierre, Ducassou, Stéphane, Frange, Pierre, Lafaurie, Matthieu, Legrand, Matthieu, Meert, Anne-Pascale, Mokart, Djamel, Naudin, Jérôme, Pene, Frédéric, Rabbat, Antoine, Raffoux, Emmanuel, Ribaud, Patricia, Richard, Jean-Christophe, Vincent, François, Zahar, Jean-Ralph, and Darmon, Michael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Rare Diseases, Good Health and Well Being, Antibiotics, Guidelines, Intensive care units, Isolation, Neutropenia, Prognosis, Public Health and Health Services, Clinical sciences
Abstract

Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complications that may require intensive care unit (ICU) admission. Specificities in the management of critically ill neutropenic patients prompted the establishment of guidelines dedicated to intensivists. These recommendations were drawn up by a panel of experts brought together by the French Intensive Care Society in collaboration with the French Group for Pediatric Intensive Care Emergencies, the French Society of Anesthesia and Intensive Care, the French Society of Hematology, the French Society for Hospital Hygiene, and the French Infectious Diseases Society. Literature review and formulation of recommendations were performed using the Grading of Recommendations Assessment, Development and Evaluation system. Each recommendation was then evaluated and rated by each expert using a methodology derived from the RAND/UCLA Appropriateness Method. Six fields are covered by the provided recommendations: (1) ICU admission and prognosis, (2) protective isolation and prophylaxis, (3) management of acute respiratory failure, (4) organ failure and organ support, (5) antibiotic management and source control, and (6) hematological management. Most of the provided recommendations are obtained from low levels of evidence, however, suggesting a need for additional studies. Seven recommendations were, however, associated with high level of evidences and are related to protective isolation, diagnostic workup of acute respiratory failure, medical management, and timing surgery in patients with typhlitis.

Published
2016

9. Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, Zijlstra, Jan G., Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Published
2021
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11. Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies

Author

Mirouse, Adrien, Resche-Rigon, Matthieu, Lemiale, Virginie, Mokart, Djamel, Kouatchet, Achille, Mayaux, Julien, Vincent, François, Nyunga, Martine, Bruneel, Fabrice, Rabbat, Antoine, Lebert, Christine, Perez, Pierre, Renault, Anne, Meert, Anne-Pascale, Benoit, Dominique, Hamidfar, Rebecca, Jourdain, Mercé, Darmon, Michaël, Azoulay, Elie, Pène, Frédéric, and on behalf of the Groupe de Recherche sur la Réanimation Respiratoire en Onco-Hématologie (Grrr-OH)

Published
2017
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13. Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

Author

Dumas, Guillaume, Demoule, Alexandre, Mokart, Djamel, Lemiale, Virginie, Nseir, Saad, Argaud, Laurent, Pène, Frédéric, Kontar, Loay, Bruneel, Fabrice, Klouche, Kada, Barbier, François, Reignier, Jean, Stoclin, Annabelle, Louis, Guillaume, Constantin, Jean-Michel, Wallet, Florent, Kouatchet, Achille, Peigne, Vincent, Perez, Pierre, Girault, Christophe, Jaber, Samir, Cohen, Yves, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lebert, Christine, Lautrette, Alexandre, Bigé, Naike, Raphalen, Jean-Herlé, Papazian, Laurent, Benoit, Dominique, Darmon, Michael, Chevret, Sylvie, and Azoulay, Elie

Published
2019
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14. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Author

Bougouin, Wulfran, Marijon, Eloi, Planquette, Benjamin, Karam, Nicole, Dumas, Florence, Celermajer, David, Jost, Daniel, Lamhaut, Lionel, Beganton, Frankie, Cariou, Alain, Meyer, Guy, Jouven, Xavier, Bureau, Côme, Charpentier, Julien, Salem, Omar Ben Hadj, Guillemet, Lucie, Arnaout, Michel, Ferre, Alexis, Geri, Guillaume, Mongardon, Nicolas, Pène, Frédéric, Chiche, Jean-Daniel, Mira, Jean-Paul, Labro, Guylaine, Belon, François, Luu, Vinh-Phuc, Chenet, Julien, Besch, Guillaume, Puyraveau, Marc, Piton, Gaël, Capellier, Gilles, Martin, Maëlle, Lascarrou, Jean-Baptiste, Le Thuaut, Aurélie, Lacherade, Jean-Claude, Martin-Lefèvre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Lebert, Christine, Bachoumas, Konstantinos, Yehia, Aihem, Henry-Laguarrigue, Matthieu, Colin, Gwenhaël, Reignier, Jean, Privat, Elodie, Escutnaire, Joséphine, Dumont, Cyrielle, Baert, Valentine, Vilhelm, Christian, Hubert, Hervé, Robert-Edan, Vincent, Lakhal, Karim, Quartin, Andrew, Hobbs, Brian, Cely, Cynthia, Bell, Cynthia, Pham, Tai, Schein, Roland, Geng, Yimin, Ng, Chaan, Ehrmann, Stephan, Gandonnière, Charlotte Salmon, Boisramé-Helms, Julie, Le Tilly, Olivier, De Bretagne, Isabelle Benz, Mercier, Emmanuelle, Mankikian, Julie, Bretagnol, Anne, Meziani, Ferhat, Halimi, Jean Michel, Le Guellec, Chantal Barin, Gaudry, Stéphane, Hajage, David, Tubach, Florence, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, de Prost, Nicolas, Lautrette, Alexandre, Mayaux, Julien, Nseir, Saad, Ricard, Jean-Damien, Dreyfuss, Didier, Robert, René, Garzotto, Franscesco, Kipnis, Eric, Tetta, Ciro, Ronco, Claudio, Schnell, David, Aurelie, Bourmaud, Reynaud, Marie, Clec’h, Christophe, Benyamina, Mourad, Vincent, François, Mariat, Christophe, Bornstain, Caroline, Rouleau, Stephane, Leroy, Christophe, Cohen, Yves, Morel, Jerome, Legrand, Matthieu, Terreaux, Jeremy, Darmon, Michaël, Cantier, Marie, Morisot, Adeline, Guérot, Emmanuel, Canet, Emmanuel, De Montmollin, Etienne, Voiriot, Guillaume, Neuville, Mathilde, Timsit, Jean-François, Sonneville, Romain, Fayssoil, Abdallah, Stojkovic, Tania, Behin, Anthony, Ogna, Adam, Lofaso, Frédéric, Laforet, Pascal, Wahbi, Karim, Prigent, Helene, Duboc, Denis, Orlikowski, David, Eymard, Bruno, Annane, Djillali, Le Guennec, Loic, Cholet, Clémentine, Bréchot, Nicolas, Hekimian, Guillaume, Besset, Sébastien, Lebreton, Guillaume, Nieszkowska, Ania, Trouillet, Jean Louis, Leprince, Pascal, Combes, Alain, Luyt, Charles-Edouard, Griton, Marion, Sesay, Musa, De Panthou, Nadia Sibaï, Bienvenu, Thomas, Biais, Matthieu, Nouette-Gaulain, Karine, Fossat, Guillaume, Baudin, Florian, Coulanges, Cécile, Bobet, Sabrine, Dupont, Arnaud, Courtes, Léa, Benzekri, Dalila, Kamel, Toufik, Muller, Grégoire, Bercault, Nicolas, Barbier, François, Runge, Isabelle, Skarzynski, Marie, Mathonnet, Armelle, Boulain, Thierry, Jouan, Youenn, Teixera, Noémie, Hassen-Khodja, Claire, Guillon, Antoine, Gaborit, Christophe, Grammatico-Guillon, Leslie, Rebière, Cécile, Azoulay, Elie, Misset, Benoit, Ruckly, Stephane, Garrouste-Orgeas, Maïté, Kentish-Barnes, Nancy, Duranteau, Jacques, Thuong, Marie, Joseph, Liliane, Renault, Anne, Lesieur, Olivier, Larbi, Anne-Gaelle Si, Viquesnel, Gérald, Zuber, Benjamin, Marque, Sophie, Kandelman, Stanislas, Pichon, Nicolas, Floccard, Bernard, Galon, Marion, Chevret, Sylvie, Kentish-Barnes, Nancy, Seegers, Valérie, Legriel, Stéphane, Jaber, Samir, Lefrant, Jean Yves, Reuter, Danielle, Guisset, Olivier, Cracco, Christophe, Seguin, Amélie, Durand-Gasselin, Jacques, Thirion, Marine, Cohen-Solal, Zoé, Foulgoc, Hélène, Rogier, Julien, Delobbe, Elsa, Schortgen, Frédérique, Asfar, Pierre, Julie, Boisramé-Helms, Grimaldi, David, Fabien, Grelon, Anguel, Nadia, Sigismond, Lasocki, Matthieu, Henry-Lagarrigue, Gonzalez, Frédéric, François, Legay, Guitton, Christophe, Schenck, Maleka, Jean-Marc, Doise, Radermacher, Peter, Kentish-Barnes, Nancy, Makunza, Joseph Nsiala, Nathalie, Mejeni Kamdem, Pierre, Akilimali, Adolphe, Kilembe Manzanza, Mahieu, Rafael, Reydel, Thomas, Jamet, Angéline, Chudeau, Nicolas, Huntzinger, Julien, Grange, Steven, Courte, Anne, Lemarie, Jérémie, Gibot, Sébastien, Champey, Julia, Dellamonica, Jean, Du Cheyron, Damien, Contou, Damien, Tadié, Jean-Marc, Cour, Martin, Beduneau, Gaetan, Marchalot, Antoine, Guérin, Laurent, Jochmans, Sebastien, Terzi, Nicolas, Preau, Sebastien, Brun-Buisson, Christian, Dessap, Armand Mekontso, Vedrenne-Cloquet, Meryl, Breinig, Sophie, Jung, Camille, Brussieux, Maxime, Marcoux, Marie-Odile, Durrmeyer, Xavier, Blondé, Renaud, Angoulvant, François, Grasset, Jérôme, Naudin, Jérôme, Dauger, Stéphane, Remy, Solenn, Kolev-Descamp, Karine, Demaret, Julie, Monneret, Guillaume, Javouhey, Etienne, Chomton, Maryline, Sauthier, Michaël, Vallieres, Emilie, Jouvet, Philippe, Geslain, Guillaume, Guellec, Isabelle, Rambaud, Jérôme, Schmidt, Matthieu, Schellongowski, Peter, Dorget, Amandine, Patroniti, Nicolo, Taccone, Fabio Silvio, Miranda, Dinis Reis, Reuter, Jean, Prodanovic, Hélène, Pierrot, Marc, Balik, Martin, Park, Sunghoon, Guérin, Claude, Papazian, Laurent, Jean, Reignier, Ayzac, Louis, Loundou, Anderson, Forel, Jean-Marie, Mezidi, Mehdi, Aublanc, Mylène, Perinel-Ragey, Sophie, Lissonde, Floriane, Louf-Durier, Aurore, Tapponnier, Romain, Yonis, Hodane, Coudroy, Remi, Frat, Jean-Pierre, Boissier, Florence, Thille, Arnaud W., Richard, Flore, Le Gullou-Guillemette, Hélène, Fahri, Jonathan, Kouatchet, Achille, Bodet-Contentin, Laetitia, Garot, Denis, Le Pennec, Déborah, Vecellio, Laurent, Tavernier, Elsa, Dequin, Pierre François, Messika, Jonathan, Martin, Yolaine, Maquigneau, Natacha, Puechberty, Christelle, Stoclin, Annabelle, Villard, Serge, Dechanet, Aline, De Jong, Audrey, Monnin, Marion, Girard, Mehdi, Chanques, Gérald, Molinari, Nicolas, Decavèle, Maxens, Campion, Sébastien, Ainsouya, Roukia, Niérat, Marie-Cécile, Raux, Mathieu, Similowski, Thomas, Demoule, Alexandre, Razazi, Keyvan, Tchir, Martial, May, Faten, Carteaux, Guillaume, Pauline, Rougevin-Baville, Marc, Andronikof, Bedos, Jean Pierre, Mehrsa, Koukabi, Mauger-Briche, Carole, Mijon, François, Trouiller, Pierre, Sztrymf, Benjamin, Cretallaz, Pierre, Mermillod-Blondin, Romain, Savary, Dominique, Sedghiani, Ines, Doghri, Hamdi, Jendoubi, Asma, Hamdi, Dhekra, Cherif, Mohamed Ali, Hechmi, Youssef Zied El, Zouheir, Jerbi, Persico, Nicolas, Maltese, Francois, Ferrigno, Cécile, Bablon, Amandine, Marmillot, Cécile, Roch, Antoine, Sedghiani, Ines, Papin, Grégory, Gainnier, Marc, Argaud, Laurent, Christophe, Adrie, Souweine, Bertrand, Goldgran-Toledano, Dany, Marcotte, Guillaume, Dumenil, Anne Sylvie, Carole, Schwebel, Cecchini, Jerôme, Tuffet, Samuel, Fartoukh, Muriel, Roux, Damien, Thyrault, Martial, Armand, Mekontso Dessap, Chauveau, Simon, Wesner, Nadège, Monnier-Cholley, Laurence, Bigé, Naïke, Ait-Oufella, Hafid, Guidet, Bertrand, Dubée, Vincent, Labroca, Pierre, Lemarié, Jérémie, Chiesa, Gérard, Laroyenne, Isabelle, Borrini, Léo, Klotz, Rémi, Sy, Quoc Phan, Cristina, Marie-Christine, Paysant, Jean, Fillâtre, Pierre, Gacouin, Arnaud, Revest, Matthieu, Tattevin, Pierre, Flecher, Erwan, Le Tulzo, Yves, Jamme, Matthieu, Daviaud, Fabrice, Marin, Nathalie, Thy, Michael, Duceau, Baptiste, Ardisson, Fanny, Sandrine, Valade, Venot, Marion, Schlemmer, Benoît, Zafrani, Lara, Pons, Stéphanie, Styfalova, Lenka, Bouadma, Lila, Radjou, Aguila, Lebut, Jordane, Mourvillier, Bruno, Dorent, Richard, Dilly, Marie-Pierre, Nataf, Patrick, Wolff, Michel, Le Gall, Aëlle, Bourcier, Simon, Tandjaoui-Lambiotte, Yacine, Das, Vincent, Alves, Mikael, Bigé, Naïke, Kamilia, Chtara, Rania, Ammar, Baccouch, Najeh, Turki, Olfa, Ben, Hmida Chokri, Bahloul, Mabrouk, Bouaziz, Mounir, Dupuis, Claire, Perozziello, Anne, Letheulle, Julien, Valette, Marc, Herrmann-Storck, Cécile, Crosby, Laura, Elkoun, Khalid, Madeux, Benjamin, Martino, Frédéric, Migueres, Hélène, Piednoir, Pascale, Posch, Matthias, Thiery, Guillaume, Huynh-Ky, Minh-Tu, Bouchard, Pierre Alexandre, Sarrazin, Jean-François, Lellouche, François, Nay, Mai-Anh, Lortat-Jacob, Brice, Rozec, Bertrand, Colnot, Marion, Belin, Nicolas, Barrot, Loïc, Navellou, Jean-Christophe, Patry, Cyrille, Chaignat, Claire, Claveau, Melanie, Claude, Frédéric, Aubron, Cécile, Mcquilten, Zoe, Bailey, Michael, Board, Jasmin, Buhr, Heidi, Cartwright, Bruce, Dennis, Mark, Forrest, Paul, Hodgson, Carol, Mcilroy, David, Murphy, Deirdre, Murray, Lynnette, Pellegrino, Vincent, Pilcher, David, Sheldrake, Jayne, Tran, Huyen, Vallance, Shirley, Cooper, Jamie, Bombled, Camille, Vidal, Charles, Margetis, Dimitri, Amour, Julien, Coart, Domien, Dubois, Jasperina, Van Herpe, Tom, Mesotten, Dieter, Bailly, Sébastien, Lucet, Jc, Lepape, Alain, L’hériteau, François, Aupée, Martine, Bervas, Caroline, Boussat, Sandrine, Berger-Carbonne, Anne, Machut, Anaïs, Savey, Anne, Tudesq, Jean-Jacques, Valade, Sandrine, Galicier, Lionel, De Bazelaire, Cédric, Munoz-Bongrand, Nicolas, Mignard, Xavier, Biard, Lucie, Mokart, Djamel, Nyunga, Martine, Bruneel, Fabrice, Rabbat, Antoine, Perez, Pierre, Meert, Anne Pascale, Benoit, Dominique, Mariotte, Eric, Ehooman, Franck, Hamidfar-Roy, Rebecca, Hourmant, Yannick, Mailloux, Arnaud, Beurton, Alexandra, Teboul, Jean-Louis, Girroto, Valentina, Laura, Galarza, Richard, Christian, Monnet, Xavier, Dubée, Vincent, Merdji, Hamid, Dang, Julien, Preda, Gabriel, Baudel, Jean-Luc, Desnos, Cyrielle, Zeitouni, Michel, Belaroussi, Ines, Parrot, Antoine, Blayau, Clarisse, Fulgencio, Jean-Pierre, Quesnel, Christophe, Labbe, Vincent, De Chambrun, Marc Pineton, Beloncle, François, Merceron, Sybille, Fedun, Yannick, Lecomte, Bernard, Devaquet, Jérôme, Puidupin, Marc, Verdière, Bruno, Amoura, Zahir, Vuillard, Constance, Xavier, Jais, Bourlier, Delphine, David, Amar, Caroline, Sattler, David, Montani, Gerald, Simmoneau, Olivier, Sitbon, Humbert, Marc, Laurent, Savale, Dujardin, Olivier, Bouglé, Adrien, Ait, Hamou Nora, Salem, Joe Elie, El-Helali, Najoua, Coppere, Zoé, Gibelin, Aude, Taconet, Clementine, Djibre, Michel, Maamar, Adel, Colobert, Elen, Fillatre, Pierre, Uhel, Fabrice, Camus, Christophe, Moraly, Josquin, Dahoumane, Redouane, Maury, Eric, Tan, Boun Kim, Emmanuel, Vivier, Pauline, Misslin, Laurence, Parmeland, Philippe, Poirié, Zahar, Jean-Ralph, Catherine, Haond, Christian, Pommier, Karim, Ait-Bouziad, Mounia, Hocine, Laura, Témime, Rasoldier, Vero Hanitra, Mager, Guy, Eraldi, Jean-Pierre, Gelinotte, Stéphanie, Bougerol, François, Dehay, Julien, Rigaud, Jean-Philippe, Declercq, Pierre Louis, Michel, Julien, Aissa, Nejla, Henard, Sandrine, Guerci, Philippe, Latar, Ichraq, Levy, Bruno, Girerd, Nicolas, Kimmoun, Antoine, Abdallah, Saousen Ben, Nakaa, Sabrine, Hraiech, Kmar, Braiek, Dhouha Ben, Adhieb, Ali, M’ghirbi, Abdelwaheb, Ousji, Ali, Hammouda, Zeineb, Abroug, Fekri, Sellami, Walid, Hajjej, Zied, Samoud, Walid, Labbene, Iheb, Ferjani, Mustapha, Medhioub, Fatma Kaaniche, Allela, Rania, Algia, Najla Ben, Cherif, Samar, Attia, Delphine, Herinjatovo, Andrianjafy, Francois, Xavier Laborne, Bouhouri, Med Aziz, Slaoui, Mohamed Taoufik, Soufi, A., Khaleq, K., Hamoudi, D., Nsiri, A., Harrar, R., Maury, Eric, Goursaud, Suzanne, Gauberti, Maxime, Labeyrie, Paul-Emile, Gaberel, Thomas, Agin, Véronique, Maubert, Eric, Vivien, Denis, Gakuba, Clément, Armel, Anwar, Abdou, Rchi, Kalouch, Samira, Yaqini, Khalid, Chlilek, Aziz, Sellami, Walid, Yedder, Soumaya Ben, Tonnelier, Alexandre, Hervé, Fabien, Halley, Guillaume, Frances, Jean-Luc, Moriconi, Mickael, Saoli, Mathieu, Garnero, Aude, Demory, Didier, Arnal, Jean Michel, Canoville, Bertrand, Daubin, Cédric, Brunet, Jennifer, Ghezala, Hassen Ben, Snouda, Salah, Ben, Chiekh Imen, Kaddour, Moez, Ouanes, Islem, Marzouk, Mahdi, Haniez, Françoise, Jaillet, Hélène, Maas, Henri, Andrivet, Pierre, Darné, Christian, Viau, François, Ghezala, Hassen Ben, Ouanes, Islem, Dangers, Laurence, Montlahuc, Claire, Perbet, Sébastien, Ouanes, Islem, Hamouda, Zeineb, Nakee, Sabrine, Ouanes-Besbes, Lamia, Meddeb, Khaoula, Khedher, Ahmed, Sma, Nesrine, Ayachi, Jihene, Khelfa, Messaouda, Fraj, Nesrine, Lakhal, Hend Ben, Hammed, Hedia, Boukadida, Raja, Hafsa, Hajer, Chouchene, Imed, Boussarsar, Mohamed, Ben, Braiek Dhouha, Ouanes-Besbes, Lamia, Benatti, Kaoutar, Dafir, A., Aissaoui, W., Elallame, W., Haddad, W., Cherkab, R., Elkettani, C., Barrou, L., Hamou, Zakaria Ait, Repessé, Xavier, Charron, Cyril, Aubry, Alix, Paternot, Alexis, Maizel, Julien, Slama, Michel, Vieillard-Baron, Antoine, Trifi, Ahlem, Abdellatif, Sami, Fatnassi, Meriem, Daly, Foued, Nasri, Rochdi, Ismail, Khaoula Ben, Lakhal, Salah Ben, Bazalgette, Florian, Daurat, Aurelien, Roger, Claire, Muller, Laurent, Doyen, Denis, Plattier, Rémi, Robert, Alexandre, Hyvernat, Hervé, Bernardin, Gilles, Jozwiak, Mathieu, Gimenez, Julia, Mercado, Pablo, Depret, François, Tilouch, Najla, Mater, Houda, Habiba, Ben Sik Ali, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Pasquier, Pierre, Vuillemin, Quentin, Schaal, Jean-Vivien, Martinez, Thibault, Duron, Sandrine, Trousselard, Marion, Schwartzbrod, Pierre-Eric, Baugnon, Thomas, Dupic, Laurent, Gout, Caroline Duracher, De Saint Blanquat, Laure, Séguret, Sylvie, Le Ficher, Gaelle, Orliaguet, Gilles, Hubert, Philippe, Bigé, Naïke, Leblanc, Guillaume, Briand, Raphael, Brousse, Lucas, Brunet, Valentine, Chatelain, Léonard, Prat, Dominique, Jacobs, Frédéric, Demars, Nadège, Hamzaoui, Olfa, Moneger, Guy, Sztrymf, Benjamin, Duburcq-Gury, Emilie, Satre-Buisson, Léa, Duburcq, Thibault, Poissy, Julien, Robriquet, Laurent, Jourdain, Merce, Sécheresse, Thierry, Miquet, Mattéo, Simond, Alexis, Usseglio, Pascal, Hamdaoui, Yamina, Boussarsar, Mohamed, Desailly, Victoire, Brun, Patrick, Iglesias, Pauline, Huet, Jérémie, Masseran, Clémence, Claudon, Antoine, Ebeyer, Clément, Truong, Thomas, Tesnière, Antoine, Mignon, Alexandre, Gaudry, Stéphane, Resiere, Dabor, Valentino, Ruddy, Fabre, Julien, Roze, Benoit, Ferge, Jean-Louis, Charbatier, Cyrille, Marie, Sabia, Scholsser, Michel, Aitsatou, Signate, Raad, Mathieu, Cabie, Andre, Mehdaoui, Hossein, Cousin, Clement, Rousseau, Christophe, Llitjos, Jean-François, Alby-Laurent, Fanny, Toubiana, Julie, Belaidouni, Nadia, Cherruault, Marlène, Tamburini, Jérome, Bouscary, Didier, Fert, Sarah, Delile, Eugénie, Besnier, Emmanuel, Coquerel, David, Nevière, Rémi, Richard, Vincent, Tamion, Fabienne, Wei, Chaojie, Louis, Huguette, Margaux, Schmitt, Eliane, Albuisson, Sophie, Orlowski, Kimmoun, Antoine, Riad, Zakaria, Coroir, Marine, Rémy, Bernard, Camille, Bombled, Joffre, Jeremie, Aegerter, Philippe, Ilic, Dejan, Ginet, Marc, Pignard, Caroline, Nguyen, Philippe, Mourey, Guillaume, Samain, Emmanuel, Pili-Floury, Sebastien, Jouffroy, Romain, Nicolas, Caill, Alvarez, Jean-Claude, Tomasso, Maraffi, Philippe, Pascal, Raphalen, Jean-Herlé, Frédéric, J. Baud, Vivien, Benoit, Pierre, Carli, Baud, Frederic, Fredj, Hana, Blel, Youssef, Brahmi, Nozha, Ghezala, Hassen Ben, Hanak, Anne-Sophie, Malissin, Isabelle, Poupon, Joel, Risede, Patricia, Chevillard, Lucie, Megarbane, Bruno, Barghouth, Manel, M’rad, Aymen, Hmida, Marwa Ben, Thabet, Hafedh, Liang, Hao, Callebert, Jacques, Lagard, Camille, Megarbane, Bruno, Habacha, Sahar, Chatbri, Bassem, Camillerapp, Christophe, Labat, Laurence, Soichot, Marion, Garçon, Pierre, Goury, Antoine, Kerdjana, Lamia, Voicu, Sebastian, Deye, Nicolas, Megarbane, Bruno, Armel, Anwar, Anas, Benqqa, Othman, Mezgui, Moumine, S., Kalouch, S., Yakini, K. K., Chlilek, A., Hajji, Ahmed, Louati, Assaad, Khaldi, Ammar, Borgi, Aida, Ghali, Nargess, Bouziri, Asma, Menif, Khaled, Ben, Jaballah Najla, Armel, Anwar, Brochon, Jeanne, Dumitrescu, Mihaela, Thévenot, Sarah, Saulnier, Jean-Pascal, Husseini, Khaled, Laland, Catherine, Cremniter, Julie, Bousseau, Anne, Castel, Olivier, Brémaud-Csizmadia, Cassandra, Diss, Margot, Portefaix, Aurélie, Berthiller, Julien, Gillet, Yves, Aoul, Nabil Tabet, Douah, Ali, Addou, Zakaria, Youbi, Houari, Moussati, Mohamed, Belhabiche, Kamel, Mir, Souad, Abada, Sanaa, Amel, Zerhouni, Aouffen, Nabil, Bouzit, Zina, Grati, Ahmed H., Dhonneur, Gilles F., Boussarsar, Mohamed, Lau, Nicolas, Mezhari, Ilham, Roucaud, Nicolas, Le Meur, Matthieu, Paulet, Rémi, Coudray, Jean-Michel, Ghomari, Wahiba Imène, Boumlik, Reda, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Yassine, Hafiani, Mohamed, Cheikh Chaigar, Khalid, Allali, Ihssan, Moussaid, Said, Elyoussoufi, Said, Salmi, Jazia, Amira Ben, Fatima, Jaziri, Wafa, Skouri, Maha, Bennasr, Khaoula, Ben Abdelghni, Sami, Turki, Abdallah Taeib, B., Medhioub, Fatma Kaaniche, Rollet-Cohen, Virginie, Sachs, Philippe, Merchaoui, Zied, Renolleau, Sylvain, Oualha, Mehdi, Eloi, Maxime, Jean, Sandrine, Demoulin, Maryne, Valentin, Cécile, Guilbert, Julia, Walti, Hervé, Carbajal, Ricardo, Leger, Pierre-Louis, Karaca-Altintas, Yasemin, Botte, Astrid, Labreuche, Julien, Drumez, Elodie, Devos, Patrick, Bour, Franck, Leclerc, Francis, Ahmed, Ayari, khaled, Menif, Louati, Assaad, Aida, Borgi, Ammar, Khaldi, Narjess, Ghali, Ahmed, Hajji, Asma, Bouziri, Jaballah, Nejla Ben, Leger, Pierre-Louis, Pansiot, Julien, Besson, Valérie, Palmier, Bruno, Baud, Olivier, Cauli, Bruno, Charriaut-Marlangue, Christiane, Mansuy, Amélie, Michel, Fabrice, Le Bel, Stéphane, Boubnova, Julia, Ughetto, Fabrice, Ovaert, Caroline, Fouilloux, Virginie, Paut, Olivier, Jacquet-Lagrèze, Matthias, Tiebergien, Nicolas, Hanna, Najib, Evain, Jean-Noël, Baudin, Florent, Courtil-Teyssedre, Sonia, Bompard, Dominique, Lilot, Marc, Chardonal, Laurent, Fellahi, Jean-Luc, Claverie, Claire, Pouessel, Guillaume, Dorkenoo, Aimée, Renaudin, Jean-Marie, Eb, Mireille, Deschildre, Antoine, Leteurtre, Stéphane, Yassine, Hafiani, Kamal, Belkadi, Adil, Oboukhlik, Ouafa, Aalalam, Mouhamed, Moussaoui, Rachid, Charkab, Lahoucine, Barrou, Dachraoui, Fahmi, Nakkaa, Sabrine, Zaineb, Hammouda, Mlika, Dorra, Gloulou, Olfa, Boussarsar, Mohamed, Zelmat, Setti-Aouicha, Batouche, Djamila-Djahida, Chaffi, Belkacem, Mazour, Fatima, Benatta, Nadia, Fathallah, Ines, Aloui, Rafaa, Zoubli, Aymen, Kouraichi, Nadia, Fathallah, Ines, Kouraichi, N., Salem, Shireen, Vicaut, Eric, Megarbane, Bruno, Ambroise, David, Loriot, Anne-Marie, Bourgogne, Emmanuel, Megarbane, Bruno, Ghadhoune, Hatem, Jihene, Guissouma, Trabelsi, Insaf, Allouche, Hend, Brahmi, Habib, Samet, Mohamed, Ghord, Hatem El, Lebeau, Rodolphe, Laplanche, Jean-Louis, Benturquia, Nadia, Megarbane, Bruno, Blel, Youssef, M’rad, A., Essafi, Fatma, Benabderrahim, A., Jouffroy, Romain, Resiere, Dabor, Sanchez, Bruno, Inamo, Jocelyn, Megarbane, Bruno, Batouche, Djamila-Djahida, Zerhouni, Amel, Tabeliouna, Kheira, Negadi, Amine, Mentouri, Zahia, Le Gall, Fanny, Hanouz, Jean-Luc, Normand, Hervé, Khoury, Abdo, Sall, Fatimata Seydou, De Luca, Alban, Pugin, Aurore, Pazart, Lionel, Vidal, Chrystelle, Leroux, Franck, Khoury, Abdo, L’Her, Erwan, Marjanovic, Nicolas, Khoury, Abdo, Desmettre, Thibault, Lambert, Christophe, Ragey, Sophie Perinel, Baboi, Loredana, Bazin, Jean-Etienne, Koffel, Catherine, Dhonneur, Gilles, Bouzit, Zina, Bradai, Larbi, Ayed, Issam Ben, Aissa, Fethi, Haouache, Hakim, Marechal, Yoann, Biston, Patrick, Piagnerelli, Michael, Bortolotti, Perrine, Colling, Delphine, Colas, Vincent, Voisin, Benoit, Dewavrin, Florent, Onimus, Thierry, Girardie, Patrick, Saulnier, Fabienne, Urbina, Tomas, Nguyen, Yann, Druoton, Anne-Lise, Soudant, Marc, Barraud, Damien, Conrad, Marie, Cravoisy-Popovic, Aurélie, Nace, Lionel, Bollaert, Pierre-Edouard, Martin, Ruste, Bitker, Laurent, Richard, Jean-Christophe, Brossier, David, Goyer, Isabelle, Marquis, Christopher, Lampin, Marie, Duhamel, Alain, Béhal, Hélène, Dhaoui, Tahar, Godeffroy, Véronique, Devouge, Eve, Evrard, Dominique, Delepoulle, Florence, Racoussot, Sylvie, Grandbastien, Bruno, Lampin, Marie, Heilbronner, Claire, Roy, Emeline, Masson, Alexandra, Hadchouel-Duvergé, Alice, Rigourd, Virginie, Delacroix, Elise, Wroblewski, Isabelle, Pin, Isabelle, Ego, Anne, Payen, Valerie, Debillon, Thierry, Millet, Anne, Denot, Julien, Berthelot, Véronique, Thueux, Emilie, Reymond, Marie, De Larrard, Alexandra, Amblard, Alain, Leger, Pierre-Louis, Aoul, Nabil Tabet, Lemiale, Virginie, Oziel, Johanna, Brule, Noelle, Moreau, Anne-Sophie, Marhbène, Takoua, Sellami, Salma, Jamoussi, Amira, Ayed, Samia, Mhiri, Emna, Slim, Leila, Khelil, Jalila Ben, Besbes, Mohamed, Chawki, Sylvain, Hamdi, Aicha, Ciroldi, Magali, Cottereau, Alice, Obadia, Edouard, Zerbib, Yoann, Andrejak, Claire, Ricome, Sylvie, Dupont, Hervé, Baudin, François, Dureau, Pauline, Tanguy, Audrey, Arbelot, Charlotte, Ben, Hassen Kais, Charfeddine, Ahmed, Granger, Benjamin, Laporte, Lucile, Hermetet, Coralie, Regaieg, Kais, Khemakhem, Rim, Chelly, Hedi, Cheikh, Chaigar Mohammed, Mountij, Hamid, Rghioui, Kawtar, Haddad, Wafae, Cherkab, Rachid, Barrou, Houcine, Naima, Aitmouden, bennani, Othmani M., Regaieg, Kais, Douib, Ahmed, Samet, Amal, Cungi, Pierre-Julien, Nguyen, Cédric, Cotte, Jean, D’aranda, Erwan, Meaudre, Eric, Avaro, Jean-Phillipe, Slaoui, Mohamed Taoufik, Mokline, Amel, Rahmani, Imene, Laajili, Achraf, Amri, Helmi, Gharsallah, Lazheri, Gasri, Bahija, Tlaili, Sofiene, Hammouda, Rym, Messadi, Amen Allah, Sudden Death Expertise Center, AKIKI Study Group, DO-RE-MI-FA Group, ENCEPHALITICA Study Group, for the HYPER2S Investigators and REVA Research Network, for the Purpura Fulminans Study Group, GFRUP RMEF, REVA ECMOnet, REA-RAISIN Study Group, for the EurêClark Study Group, and Groupe Communication et Simulation en Pédiatrie

Published
2017
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15. Increased mortality in hematological malignancy patients with acute respiratory failure from undetermined etiology: a Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie (Grrr-OH) study

Author

Contejean, Adrien, Lemiale, Virginie, Resche-Rigon, Matthieu, Mokart, Djamel, Pène, Frédéric, Kouatchet, Achille, Mayaux, Julien, Vincent, François, Nyunga, Martine, Bruneel, Fabrice, Rabbat, Antoine, Perez, Pierre, Meert, Anne-Pascale, Benoit, Dominique, Hamidfar, Rebecca, Darmon, Michael, Jourdain, Mercé, Renault, Anne, Schlemmer, Benoît, and Azoulay, Elie

Published
2016
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17. Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. A groupe de recherche respiratoire en réanimation onco-hématologique (Grrr-OH) study

Author

Lemiale, Virginie, Resche-Rigon, Matthieu, Mokart, Djamel, Pène, Frederic, Rabbat, Antoine, Kouatchet, Achille, Vincent, François, Bruneel, Fabrice, Nyunga, Martine, Lebert, Christine, Perez, Pierre, Meert, Anne-Pascale, Benoit, Dominique, Chevret, Sylvie, and Azoulay, Elie

Published
2015
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18. One-year Mortality of Cancer Patients with an Unplanned ICU Admission:A Cohort Analysis Between 2008 and 2017 in the Netherlands

Author

van der Zee, Esther N., Termorshuizen, Fabian, Benoit, Dominique D., de Keizer, Nicolette F., Bakker, Jan, Kompanje, Erwin J.O., Rietdijk, Wim J.R., Epker, Jelle L., van der Zee, Esther N., Termorshuizen, Fabian, Benoit, Dominique D., de Keizer, Nicolette F., Bakker, Jan, Kompanje, Erwin J.O., Rietdijk, Wim J.R., and Epker, Jelle L.

Abstract

Introduction: A decrease in short-term mortality of critically ill cancer patients with an unplanned intensive care unit (ICU) admission has been described. Few studies describe a change over time of 1-year mortality. Therefore, we examined the 1-year mortality of cancer patients (hematological or solid) with an unplanned ICU admission and we described whether the mortality changed over time. Methods: We used the National Intensive Care Evaluation (NICE) registry and extracted all patients with an unplanned ICU admission in the Netherlands between 2008 and 2017. The primary outcome was 1-year mortality, analyzed with a mixed-effects Cox proportional hazard regression. We compared the 1-year mortality of cancer patients to that of patients without cancer. Furthermore, we examined changes in mortality over the study period. Results: We included 470,305 patients: 10,401 with hematological cancer, 35,920 with solid cancer, and 423,984 without cancer. The 1-year mortality rates were 60.1%, 46.2%, and 28.3% respectively (P<.01). Approximately 30% of the cancer patients surviving their hospital admission died within 1 year, this was 12% in patients without cancer. In hematological patients, 1-year mortality decreased between 2008 and 2011, after which it stabilized. In solid cancer patients, inspection showed neither an increasing nor decreasing trend over the inclusion period. For patients without cancer, 1-year mortality decreased between 2008 and 2013, after which it stabilized. A clear decrease in hospital mortality was seen within all three groups. Conclusion: The 1-year mortality of cancer patients with an unplanned ICU admission (hematological and solid) was higher than that of patients without cancer. About one-third of the cancer patients surviving their hospital admission died within 1 year after ICU admission. We found a decrease in 1-year mortality until 2011 in hematology patients and no decrease in solid cancer patients. Our results suggest that for man

Published
2022

19. Coaching doctors to improve ethical decision-making in adult hospitalised patients potentially receiving excessive treatment: Study protocol for a stepped wedge cluster randomised controlled trial.

Author

Benoit, Dominique D., Vanheule, Stijn, Manesse, Frank, Anseel, Frederik, De Soete, Geert, Goethals, Katrijn, Lievrouw, An, Vansteelandt, Stijn, De Haan, Erik, and Piers, Ruth

Subjects
*ETHICAL decision making, *ADULTS, *CLUSTER randomized controlled trials, *MEDICAL protocols, *SEQUENTIAL analysis, *GROUP dynamics
Abstract

Background: Fast medical progress poses a significant challenge to doctors, who are asked to find the right balance between life-prolonging and palliative care. Literature indicates room for enhancing openness to discuss ethical sensitive issues within and between teams, and improving decision-making for benefit of the patient at end-of-life. Methods: Stepped wedge cluster randomized trial design, run across 10 different departments of the Ghent University Hospital between January 2022 and January 2023. Dutch speaking adult patients and one of their relatives will be included for data collection. All 10 departments were randomly assigned to start a 4-month coaching period. Junior and senior doctors will be coached through observation and debrief by a first coach of the interdisciplinary meetings and individual coaching by the second coach to enhance self-reflection and empowering leadership and managing group dynamics with regard to ethical decision-making. Nurses, junior doctors and senior doctors anonymously report perceptions of excessive treatment via the electronic patient file. Once a patient is identified by two or more different clinicians, an email is sent to the second coach and the doctor in charge of the patient. All nurses, junior and senior doctors will be invited to fill out the ethical decision making climate questionnaire at the start and end of the 12-months study period. Primary endpoints are (1) incidence of written do-not-intubate and resuscitate orders in patients potentially receiving excessive treatment and (2) quality of ethical decision-making climate. Secondary endpoints are patient and family well-being and reports on quality of care and communication; and clinician well-being. Tertiairy endpoints are quantitative and qualitative data of doctor leadership quality. Discussion: This is the first randomized control trial exploring the effects of coaching doctors in self-reflection and empowering leadership, and in the management of team dynamics, with regard to ethical decision-making about patients potentially receiving excessive treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Critically ill cancer patient's resuscitation: a Belgian/French societies' consensus conference

Author

Meert, Anne-Pascale, Wittnebel, Sebastian, Holbrechts, Stéphane, Toffart, Anne-Claire, Lafitte, Jean-Jacques, Piagnerelli, Michaël, Lemaitre, France, Peyrony, Olivier, Calvel, Laurent, Lemaitre, Jean, Canet, Emmanuel, Demoule, Alexandre, Darmon, Michael, Sculier, Jean-Paul, Voigt, Louis, Lemiale, Virginie, Pène, Frédéric, Schnell, David, Lengliné, Etienne, Berghmans, Thierry, Fiévet, Laurence, Jungels, Christiane, Wang, Xiaoxiao, Bold, Ionela, Pistone, Aureliano, Salaroli, Adriano, Grigoriu, Bogdan Dragos, Benoit, Dominique, and Critically ill cancer patients consensus conference group

Subjects
medicine.medical_specialty, Resuscitation, Critical Care, Critical Illness, Conference Reports and Expert Panel, medicine.medical_treatment, Context (language use), Critical Care and Intensive Care Medicine, law.invention, Belgium, law, Neoplasms, Anesthesiology, Intensive care, medicine, Humans, Haematological, Cardiopulmonary resuscitation, Intensive care medicine, Critically ill, Cancer, Mechanical ventilation, business.industry, Sciences bio-médicales et agricoles, Respiration, Artificial, Triage, Intensive care unit, Intensive Care Units, ICU, business, Systematic Reviews as Topic
Abstract

To respond to the legitimate questions raised by the application of invasive methods of monitoring and life-support techniques in cancer patients admitted in the ICU, the European Lung Cancer Working Party and the Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique, set up a consensus conference. The methodology involved a systematic literature review, experts' opinion and a final consensus conference about nine predefined questions1. Which triage criteria, in terms of complications and considering the underlying neoplastic disease and possible therapeutic limitations, should be used to guide admission of cancer patient to intensive care units?2. Which ventilatory support [High Flow Oxygenation, Non-invasive Ventilation (NIV), Invasive Mechanical Ventilation (IMV), Extra-Corporeal Membrane Oxygenation (ECMO)] should be used, for which complications and in which environment?3. Which support should be used for extra-renal purification, in which conditions and environment?4. Which haemodynamic support should be used, for which complications, and in which environment?5. Which benefit of cardiopulmonary resuscitation in cancer patients and for which complications?6. Which intensive monitoring in the context of oncologic treatment (surgery, anti-cancer treatment …)?7. What specific considerations should be taken into account in the intensive care unit?8. Based on which criteria, in terms of benefit and complications and taking into account the neoplastic disease, patients hospitalized in an intensive care unit (or equivalent) should receive cellular elements derived from the blood (red blood cells, white blood cells and platelets)?9. Which training is required for critical care doctors in charge of cancer patients?, info:eu-repo/semantics/published

Published
2021

24. Acute kidney injury in critically ill patients with haematological malignancies: results of a multicentre cohort study from the Groupe de Recherche en Réanimation Respiratoire en Onco-Hématologie

Author

Darmon, Michael, Vincent, François, Canet, Emmanuel, Mokart, Djamel, Pène, Frédéric, Kouatchet, Achille, Mayaux, Julien, Nyunga, Martine, Bruneel, Fabrice, Rabbat, Antoine, Lebert, Christine, Perez, Pierre, Renault, Anne, Meert, Anne-Pascale, Benoit, Dominique, Hamidfar, Rebecca, Jourdain, Mercé, Schlemmer, Benoit, Chevret, Sylvie, Lemiale, Virginie, and Azoulay, Elie

Published
2015
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27. Additional file 4 of Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, Zijlstra, Jan G., Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Subjects
health care facilities, manpower, and services
Abstract

Additional file 4: Fig. S2. a Time from ICU admission until at least 2 PECs during ICU stay (unweighted). b Time from ICU admission until death (unweighted). C Time from ICU admission until TLD during ICU stay (unweighted). TLD: treatment limitation decision, PEC: Perceptions of Excessive Care.

Published
2021
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28. Additional file 2 of Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, Zijlstra, Jan G., Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Abstract

Additional file 2. Master dissertation of E. Uyttersprot.

Published
2021
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29. Additional file 5 of Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, G.Zijlstra, Jan, Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Abstract

Additional file 5: Table S3. Mortality and TLDs across subgroups (unweighted results)

Published
2021
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30. Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure

Author

Lemiale, V, Dumas, G, Demoule, A, Pène, F, Kouatchet, A, Bisbal, M, Nseir, S, Argaud, L, Kontar, L, Klouche, K, Barbier, F, Seguin, A, Louis, G, Constantin, JM, Mayaux, J, Wallet, F, Peigne, V, Girault, C, Oziel, J, Nyunga, M, Terzi, N, Bouadma, L, Lautrette, A, Bige, N, Raphalen, JH, Papazian, L, Bruneel, F, Lebert, C, Benoit, Dominique, Meert, AP, Jaber, S, Mokart, D, Darmon, M, Azoulay, E, de Recherche en Reanimation Respiratoire du patient d’Onco-Hématologie (GRRR-OH, Groupe, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Picardie Jules Verne (UPJV), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
medicine.medical_specialty, Multivariate analysis, Oxygenation index, high-flow nasal oxygen, medicine.medical_treatment, Acute respiratory failure, Critical Care and Intensive Care Medicine, medicine.disease_cause, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Anesthesiology, Medicine and Health Sciences, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Intubation, Immunocompromised, acute respiratory failure, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Correction, 030208 emergency & critical care medicine, lcsh:RC86-88.9, High-flow nasal oxygen, medicine.disease, 3. Good health, Pneumonia, immunocompromised, 030228 respiratory system, Anesthesia, Economie, business, Nasal cannula
Abstract

Background: Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in immunocompromised patients, including all patients who received high-flow nasal cannula (HFNC). The first objective was to evaluate the accuracy of the ROX index to predict intubation for patients with acute respiratory failure. Results: In the study, 302 patients received HFNC. Acute respiratory failure was mostly related to pneumonia (n = 150, 49.7%). Within 2 (1–3) days, 115 (38.1%) patients were intubated. The ICU mortality rate was 27.4% (n = 83). At 6 h, the ROX index was lower for patients who needed intubation compared with those who did not [4.79 (3.69–7.01) vs. 6.10 (4.48–8.68), p < 0.001]. The accuracy of the ROX index to predict intubation was poor [AUC = 0.623 (0.557–0.689)], with low performance using the threshold previously found (4.88). In multivariate analysis, a higher ROX index was still independently associated with a lower intubation rate (OR = 0.89 [0.82–0.96], p = 0.04). Conclusion: A ROX index greater than 4.88 appears to have a poor ability to predict intubation in immunocompromised patients with acute respiratory failure, although it remains highly associated with the risk of intubation and may be useful to stratify such risk in future studies., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

31. Additional file 4 of Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study

Author

Oeyen, Sandra, De Corte, Wouter, Benoit, Dominique, Annemans, Lieven, Dhondt, Annemieke, Vanholder, Raymond, Decruyenaere, Johan, and Hoste, Eric

Abstract

Variability in SF-36. In this additional file, more detailed information is given regarding variability of the SF-36 at the different time points in the 1-year cohort and 4-year cohort. Median norm-based scores with interquartile ranges on the different domains of the SF-36 over time are given in a table. (PDF 81 kb)

Published
2021
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32. Additional file 2 of Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study

Author

Oeyen, Sandra, De Corte, Wouter, Benoit, Dominique, Annemans, Lieven, Dhondt, Annemieke, Vanholder, Raymond, Decruyenaere, Johan, and Hoste, Eric

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

SF-36 assessments over time. In this additional file, evolutions in SF-36 assessments are described through figures in the 1-year cohort (47 AKI-RRT (A) and 94 non-AKI-RRT patients (B)) and in the 4-year cohort (28 AKI-RRT (C) patients and 28 non-AKI-RRT patients (D)). Percentages of patients with some or severe problems in the different domains of the SF-36 are given over the different time points: baseline, 3 months and 1 year (1-year cohort) and baseline, 3 months, 1 year and 4 years (4-year cohort). (PDF 126 kb)

Published
2021
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33. Additional file 1 of Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, G.Zijlstra, Jan, Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Subjects
Data_FILES
Abstract

Additional file 1. Definitions of collected data.

Published
2021
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35. Additional file 3 of Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique D., van der Zee, Esther N., Darmon, Michael, Reyners, An K. L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, Zijlstra, Jan G., Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin J. O., Piers, Ruth, and Azoulay, Elie

Subjects
genetic structures, sense organs, behavioral disciplines and activities, psychological phenomena and processes
Abstract

Additional file 3: Fig. S1. Flowchart study unweighted results: number of ICU’s, clinicians, perceptions and patients. PEC: Perceptions of Excessive Care. Combined endpoint: death, poor quality of life or not being at home.

Published
2021
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36. Additional file 1 of Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study

Author

Oeyen, Sandra, De Corte, Wouter, Benoit, Dominique, Annemans, Lieven, Dhondt, Annemieke, Vanholder, Raymond, Decruyenaere, Johan, and Hoste, Eric

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

EQ-5D assessments over time. In this additional file, evolutions in EQ-5D assessments are described through figures in the 1-year cohort (47 AKI-RRT (A) and 94 non-AKI-RRT patients (B)) and in the 4-year cohort (28 AKI-RRT (C) patients and 28 non-AKI-RRT patients (D)). Percentages of patients with some or severe problems in the different dimensions of the EQ-5D are given over the different time points: baseline, 3 months and 1 year (1-year cohort) and baseline, 3 months, 1 year and 4 years (4-year cohort). (PDF 111 kb)

Published
2021
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37. Hepatic dysfunction impairs prognosis in critically ill patients with hematological malignancies: A post-hoc analysis of a prospective multicenter multinational dataset

Author

Bisbal, Magali, Darmon, Michael, Saillard, Colombe, Mallet, Vincent, Mouliade, Charlotte, Lemiale, Virginie, Benoit, Dominique, Pène, Frédéric, Kouatchet, Achille, Demoule, Alexandre, Vincent, Francois, Nyunga, Martine, Bruneel, Fabrice, Lebert, Christine, Renault, Anne, Meert, Anne-Pascale, Hamidfar, Rébecca, Jourdain, Mercé, Azoulay, Elie, Mokart, Djamel, Bisbal, Magali, Darmon, Michael, Saillard, Colombe, Mallet, Vincent, Mouliade, Charlotte, Lemiale, Virginie, Benoit, Dominique, Pène, Frédéric, Kouatchet, Achille, Demoule, Alexandre, Vincent, Francois, Nyunga, Martine, Bruneel, Fabrice, Lebert, Christine, Renault, Anne, Meert, Anne-Pascale, Hamidfar, Rébecca, Jourdain, Mercé, Azoulay, Elie, and Mokart, Djamel

Abstract

Purpose: Hyperbilirubinemia is frequent in patients with hematological malignancies admitted to the intensive care unit (ICU). Literature about hepatic dysfunction (HD) in this context is scarce. Methods: We investigated the prognostic impact of HD analyzing a prospective multicenter cohort of 893 critically ill hematology patients. Two groups were defined: patients with HD (total bilirubin ≥33 μmol/L at ICU admission) and patients without HD. Results: Twenty one percent of patients were found to have HD at ICU admission. Cyclosporine, antimicrobials before ICU admission, abdominal symptoms, ascites, history of liver disease, neutropenia, increased serum creatinine and myeloma were independently associated with HD. Etiology remained undetermined in 73% of patients. Hospital mortality was 56.3% and 36.3% respectively in patients with and without HD (p < 0.0001). Prognostic factors independently associated with hospital mortality in HD group were, performance status >1 (OR = 2.07, 95% CI = 1.49–2.87, p < 0.0001), invasive mechanical ventilation (OR = 3.92, 95% CI = 2.69–5.71, p < 0.0001), renal replacement therapy (OR = 1.74, 95% CI = 1.22–2.47, p = 0.002), vasoactive drug (OR = 1.81, 95% CI = 1.21–2.71, p = 0.004) and SOFA score without bilirubin level at ICU admission (OR = 1.09, 95% CI = 1.04–1.14, p < 0.0001). Conclusions: HD is common, underestimated, infrequently investigated, and is associated with impaired outcome in critically ill hematology patients. HD should be considered upon ICU admission and managed as other organ dysfunctions., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

38. Feasibility of ICU follow-up consultations: A mixed approach

Author

Preiser, Jean-Charles, Creteur, Jacques, Sculier, Jean-Paul, Motte, Serge, Benoit, Dominique, Bulpa, Pierre, Kornreich, Charles, Piagnerelli, Michaël, Prevedello, Danielle Heloisa, Preiser, Jean-Charles, Creteur, Jacques, Sculier, Jean-Paul, Motte, Serge, Benoit, Dominique, Bulpa, Pierre, Kornreich, Charles, Piagnerelli, Michaël, and Prevedello, Danielle Heloisa

Abstract

En dépit d’arguments convaincants en faveur de la mise en œuvre d'un programme de suivi en soins intensifs, les centres expérimentés qui gèrent ces programmes depuis des années en analysent la faisabilité du point de vue des coûts, sans succès. Bien qu'aucun rapport coût-efficacité n'ait encore été démontré, l'équipe des soins intensifs pense intuitivement que la mise en œuvre d'un programme de suivi en soins intensifs pourrait présenter des avantages. Le sens de la responsabilité sociale guide les prestataires de soins de santé à tous les niveaux de soins. Peu d'analyses secondaires ou de résultats secondaires ont montré un bénéfice psychologique pour les patients et les familles qui ont participé à un programme de suivi en soins intensifs. Cependant, aucune étude de faisabilité du point de vue des valeurs n'avait été menée avant cette thèse.Malgré les progrès technologiques et, par conséquent, la diminution du taux de mortalité en soins intensifs, de plus en plus de patients sont confrontés à des conséquences à long terme. L'idée d'un suivi en soins intensifs visant à traiter ces conséquences pour améliorer la qualité de vie des patients semble logique. Même si quelques études qualitatives ont démontré une amélioration de la qualité de vie (QV) après la sortie de l'USI, la QV ne revient pas au niveau connu avant la maladie qui a motivé l'admission. La QV des survivants des soins intensifs a été rapportée comme étant inférieure à celle des personnes qui n'ont pas été admises en soins intensifs.En ce qui concerne le système de santé belge, aucun modèle standard n'est disponible à ce jour pour guider les professionnels de la santé vers la mise en œuvre ou les prochaines étapes des soins une fois que le patient a quitté l'unité de soins intensifs. Le système de santé influence la progression et le déroulement d'un nouveau programme. Lorsque les décideurs comprennent l'importance de l'innovation et de l'amélioration, cela stimule l'action des nouveaux programmes et sou, Doctorat en Sciences médicales (Médecine), info:eu-repo/semantics/nonPublished

Published
2021

39. Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Author

Benoit, Dominique, van der Zee, Esther E.N., Darmon, Michael, Reyners, An A.K.L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, G.Zijlstra, Jan, Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin Jo E.J.O., Piers, Ruth R.D., Azoulay, Elie, Benoit, Dominique, van der Zee, Esther E.N., Darmon, Michael, Reyners, An A.K.L., Metaxa, Victoria, Mokart, Djamel, Wilmer, Alexander, Depuydt, Pieter, Hvarfner, Andreas, Rusinova, Katerina, G.Zijlstra, Jan, Vincent, François, Lathyris, Dimitrios, Meert, Anne-Pascale, Devriendt, Jacques, Uyttersprot, Emma, Kompanje, Erwin Jo E.J.O., Piers, Ruth R.D., and Azoulay, Elie

Abstract

Background: Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptions of excessive care (PECs) by ICU clinicians in patients with and without cancer. Methods: This study is a sub-analysis of the large multicentre DISPROPRICUS study. Clinicians of 56 ICUs in Europe and the United States completed a daily questionnaire about the appropriateness of care during a 28-day period. We compared the cumulative incidence of patients with concordant PECs, treatment limitation decisions (TLDs) and death between patients with uncontrolled and controlled cancer, and patients without cancer. Results: Of the 1641 patients, 117 (7.1%) had uncontrolled cancer and 270 (16.4%) had controlled cancer. The cumulative incidence of concordant PECs in patients with uncontrolled and controlled cancer versus patients without cancer was 20.5%, 8.1%, and 9.1% (p < 0.001 and p = 0.62, respectively). In patients with concordant PECs, we found no evidence for a difference in time from admission until death (HR 1.02, 95% CI 0.60–1.72 and HR 0.87, 95% CI 0.49–1.54) and TLDs (HR 0.81, 95% CI 0.33–1.99 and HR 0.70, 95% CI 0.27–1.81) across subgroups. In patients without concordant PECs, we found differences between the time from admission until death (HR 2.23, 95% CI 1.58–3.15 and 1.66, 95% CI 1.28–2.15), without a corresponding increase in time until TLDs (NA, p = 0.3 and 0.7) across subgroups. Conclusions: The absence of a difference in time from admission until TLDs and death in patients with concordant PECs makes bias by ICU clinicians towards cancer patients unlikely. However, the differences between the time from admission until death, without a corresponding increase in time until TLDs, suggest prognostic unawareness, uncertainty or optimism in ICU clinicians who did not provide PECs, more specifically in patients with uncontrolled cancer. This, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

40. Assessment of mortality and performance status in critically ill cancer patients:A retrospective cohort study

Author

van der Zee, Esther N., Noordhuis, Lianne M., Epker, Jelle L., van Leeuwen, Nikki, Wijnhoven, Bas P.L., Benoit, Dominique D., Bakker, Jan, Kompanje, Erwin J.O., van der Zee, Esther N., Noordhuis, Lianne M., Epker, Jelle L., van Leeuwen, Nikki, Wijnhoven, Bas P.L., Benoit, Dominique D., Bakker, Jan, and Kompanje, Erwin J.O.

Abstract

Introduction Given clinicians’ frequent concerns about unfavourable outcomes, Intensive Care Unit (ICU) triage decisions in acutely ill cancer patients can be difficult, as clinicians may have doubts about the appropriateness of an ICU admission. To aid to this decision making, we studied the survival and performance status of cancer patients 2 years following an unplanned ICU admission. Materials and methods This was a retrospective cohort study in a large tertiary referral university hospital in the Netherlands. We categorized all adult patients with an unplanned ICU admission in 2017 into two groups: patients with or without an active malignancy. Descriptive statistics, Pearson’s Chi-square tests and the Mann-Whitney U tests were used to evaluate the primary objective 2-year mortality and performance status. A good performance status was defined as ECOG performance status 0 (fully active) or 1 (restricted in physically strenuous activity but ambulatory and able to carry out light work). A multivariable binary logistic regression analysis was used to identify factors associated with 2-year mortality within cancer patients. Results Of the 1046 unplanned ICU admissions, 125 (12%) patients had cancer. The 2-year mortality in patients with cancer was significantly higher than in patients without cancer (72% and 42.5%, P <0.001). The median performance status at 2 years in cancer patients was 1 (IQR 0–2). Only an ECOG performance status of 2 (OR 8.94; 95% CI 1.21–65.89) was independently associated with 2-year mortality. Conclusions In our study, the majority of the survivors have a good performance status 2 years after ICU admission. However, at that point, three-quarter of these cancer patients had died, and mortality in cancer patients was significantly higher than in patients without cancer. ICU admission decisions in acutely ill cancer patients should be based on performance status, severity of illness and long-term prognosis, and this should be communicated

Published
2021

41. Outcome of cancer patients considered for intensive care unit admission in two university hospitals in the Netherlands:the danger of delayed ICU admissions and off-hour triage decisions

Author

van der Zee, Esther N., Benoit, Dominique D., Hazenbroek, Marinus, Bakker, Jan, Kompanje, Erwin J.O., Kusadasi, Nuray, Epker, Jelle L., van der Zee, Esther N., Benoit, Dominique D., Hazenbroek, Marinus, Bakker, Jan, Kompanje, Erwin J.O., Kusadasi, Nuray, and Epker, Jelle L.

Abstract

Background: Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an association could be found between 30-day mortality, and ICU admission consultation conditions and triage decisions. Methods: We conducted a retrospective cohort study in two large referral university hospitals in the Netherlands. We identified all adult cancer patients for whom ICU admission was requested from 2016 to 2019. Via a multivariable logistic regression analysis, we assessed the association between 30-day mortality, and ICU admission consultation conditions and triage decisions. Results: Of the 780 cancer patients for whom ICU admission was requested, 332 patients (42.6%) were considered ‘too well to benefit’ from ICU admission, 382 (49%) patients were immediately admitted to the ICU and 66 patients (8.4%) were considered ‘too sick to benefit’ according to the consulting intensivist(s). The 30-day mortality in these subgroups was 30.1%, 36.9% and 81.8%, respectively. In the patient group considered ‘too well to benefit’, 258 patients were never admitted to the ICU and 74 patients (9.5% of the overall study population, 22.3% of the patients ‘too well to benefit’) were admitted to the ICU after a second ICU admission request (delayed ICU admission). Thirty-day mortality in these groups was 25.6% and 45.9%. After adjustment for confounders, ICU consultations during off-hours (OR 1.61, 95% CI 1.09–2.38, p-value 0.02) and delayed ICU admission (OR 1.83, 95% CI 1.00–3.33, p-value 0.048 compared to “ICU admission”) were independently associated with 30-day mortality. Conclusion: The ICU denial rate in our study was high (51%). Sixty percent of the ICU triage decisions in cancer patients were made during off-hours, and 22.3% of the patients initially considered “too well to benefit” from ICU admission were subsequently admitted to the ICU. Both decisions during off-hours and a delayed ICU admissi

Published
2021

42. Performance of the ROX index to predict intubation in immunocompromised patients receiving high-flow nasal cannula for acute respiratory failure

Author

Lemiale, Virginie, Dumas, Guillaume, Demoule, Alexandre, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Nseir, Saad, Argaud, Laurent, Kontar, Loay, Klouche, Kada, Barbier, François, Seguin, Amélie, Louis, Guillaume, Constantin, Jean Michel, Mayaux, Julien, Wallet, Florent, Peigne, Vincent, Girault, Christophe, Oziel, Johanna, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lautrette, Alexandre, Bige, Naike, Raphalen, Jean Herle, Papazian, Laurent, Bruneel, Fabrice, Lebert, Christine, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Mokart, Djamel, Darmon, Michael, Azoulay, Elie, Lemiale, Virginie, Dumas, Guillaume, Demoule, Alexandre, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Nseir, Saad, Argaud, Laurent, Kontar, Loay, Klouche, Kada, Barbier, François, Seguin, Amélie, Louis, Guillaume, Constantin, Jean Michel, Mayaux, Julien, Wallet, Florent, Peigne, Vincent, Girault, Christophe, Oziel, Johanna, Nyunga, Martine, Terzi, Nicolas, Bouadma, Lila, Lautrette, Alexandre, Bige, Naike, Raphalen, Jean Herle, Papazian, Laurent, Bruneel, Fabrice, Lebert, Christine, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Mokart, Djamel, Darmon, Michael, and Azoulay, Elie

Abstract

Background: Delayed intubation is associated with high mortality. There is a lack of objective criteria to decide the time of intubation. We assessed a recently described combined oxygenation index (ROX index) to predict intubation in immunocompromised patients. The study is a secondary analysis of randomized trials in immunocompromised patients, including all patients who received high-flow nasal cannula (HFNC). The first objective was to evaluate the accuracy of the ROX index to predict intubation for patients with acute respiratory failure. Results: In the study, 302 patients received HFNC. Acute respiratory failure was mostly related to pneumonia (n = 150, 49.7%). Within 2 (1–3) days, 115 (38.1%) patients were intubated. The ICU mortality rate was 27.4% (n = 83). At 6 h, the ROX index was lower for patients who needed intubation compared with those who did not [4.79 (3.69–7.01) vs. 6.10 (4.48–8.68), p < 0.001]. The accuracy of the ROX index to predict intubation was poor [AUC = 0.623 (0.557–0.689)], with low performance using the threshold previously found (4.88). In multivariate analysis, a higher ROX index was still independently associated with a lower intubation rate (OR = 0.89 [0.82–0.96], p = 0.04). Conclusion: A ROX index greater than 4.88 appears to have a poor ability to predict intubation in immunocompromised patients with acute respiratory failure, although it remains highly associated with the risk of intubation and may be useful to stratify such risk in future studies., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

43. Impact of early ICU admission for critically ill cancer patients: Post-hoc analysis of a prospective multicenter multinational dataset.

Author

Hourmant, Yannick, Kouatchet, Achille, Lopez, René, Mokart, Djamel, Pène, Frédéric, Mayaux, Julien, Bruneel, Fabrice, Lebert, Christine, Renault, Anne, Meert, Anne-Pascale, Benoit, Dominique, Lemiale, Virginie, Azoulay, Elie, Darmon, Michael, Hourmant, Yannick, Kouatchet, Achille, Lopez, René, Mokart, Djamel, Pène, Frédéric, Mayaux, Julien, Bruneel, Fabrice, Lebert, Christine, Renault, Anne, Meert, Anne-Pascale, Benoit, Dominique, Lemiale, Virginie, Azoulay, Elie, and Darmon, Michael

Abstract

Objectives: Early intensive care unit (ICU) admission, in Critically Ill Cancer Patients (CICP), is believed to have contributed to the prognostic improvement of critically ill cancer patients. The primary objective of this study was to assess the association between early ICU admission and hospital mortality in CICP. Design: Retrospective analysis of a prospective multicenter dataset. Early admission was defined as admission in the ICU < 24 h of hospital admission. We assessed the association between early ICU admission and hospital mortality in CICP via survival analysis and propensity score matching. Results: Of the 1011patients in our cohort, 1005 had data available regarding ICU admission timing and were included. Overall, early ICU admission occurred in 455 patients (45.3%). Crude hospital mortality in patients with early and delayed ICU admission was 33.6% (n = 153) vs. 43.1% (n = 237), respectively (P = 0.02). After adjustment for confounders, early compared to late ICU admission was not associated with hospital mortality (HR 0.92; 95%CI 0.76–1.11). After propensity score matching, hospital mortality did not differ between patients with early (35.2%) and late (40.6%) ICU admission (P = 0.13). In the matched cohort, early ICU admission was not associated with mortality after adjustment on SOFA score (HR 0.89; 95%CI 0.71–1.12). Similar results were obtained after adjustment for center effect. Conclusion: In this cohort, early ICU admission was not associated with a better outcome after adjustment for confounder and center effect. The uncertainty with regard to the beneficial effect of early ICU on hospital mortality suggests the need for an interventional study., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

46. Determinants of Procedural Pain Intensity in the Intensive Care Unit. The Europain® Study

Author

Puntillo, Kathleen A., Max, Adeline, Timsit, Jean-Francois, Vignoud, Lucile, Chanques, Gerald, Robleda, Gemma, Roche-Campo, Ferran, Mancebo, Jordi, Divatia, Jigeeshu V., Soares, Marcio, Ionescu, Daniela C., Grintescu, Ioana M., Vasiliu, Irena L., Maggiore, Salvatore Maurizio, Rusinova, Katerina, Owczuk, Radoslaw, Egerod, Ingrid, Papathanassoglou, Elizabeth D. E., Kyranou, Maria, Joynt, Gavin M., Burghi, Gastón, Freebairn, Ross C., Ho, Kwok M., Kaarlola, Anne, Gerritsen, Rik T., Kesecioglu, Jozef, Sulaj, Miroslav M. S., Norrenberg, Michelle, Benoit, Dominique D., Seha, Myriam S. G., Hennein, Akram, Periera, Fernando J., Benbenishty, Julie S., Abroug, Fekri, Aquilina, Andrew, Monte, Júlia R. C., An, Youzhong, and Azoulay, Elie

Published
2014
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50. Oxygenation Strategy during Acute Respiratory Failure in Critically-Ill Immunocompromised Patients

Author

Lemiale, Virginie, De Jong, Audrey, Dumas, Guillaume, Demoule, Alexandre, Mokart, Djamel, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Bruneel, Fabrice, Lebert, Christine, Vinatier, Isabelle, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Darmon, Michael, Azoulay, Elie, Lemiale, Virginie, De Jong, Audrey, Dumas, Guillaume, Demoule, Alexandre, Mokart, Djamel, Pène, Frédéric, Kouatchet, Achille, Bisbal, Magali, Bruneel, Fabrice, Lebert, Christine, Vinatier, Isabelle, Benoit, Dominique, Meert, Anne-Pascale, Jaber, Samir, Darmon, Michael, and Azoulay, Elie

Abstract

Objectives: To assess the response to initial oxygenation strategy according to clinical variables available at admission. Design: Multicenter cohort study. Setting: Thirty French and Belgium medical ICU. Subjects: Immunocompromised patients with hypoxemic acute respiratory failure. Interventions: None. Measurements and Main Results: Data were extracted from the Groupe de Recherche en Reanimation Respiratoire du patient d'Onco-Hématologie database. Need for invasive mechanical ventilation was the primary endpoint. Secondary endpoint was day-28 mortality. Six-hundred forty-nine patients were included. First oxygenation strategies included standard oxygen (n = 245, 38%), noninvasive ventilation (n = 285; 44%), high-flow nasal cannula oxygen (n = 55; 8%), and noninvasive ventilation + high-flow nasal cannula oxygen (n = 64; 10%). Bilateral alveolar pattern (odds ratio = 1.67 [1.03-2.69]; p = 0.04), bacterial (odds ratio = 1.98 [1.07-3.65]; p = 0.03) or opportunistic infection (odds ratio = 4.75 [2.23-10.1]; p < 0.001), noninvasive ventilation use (odds ratio = 2.85 [1.73-4.70]; p < 0.001), Sequential Organ Failure Assessment score (odds ratio = 1.19 [1.10-1.28]; p < 0.001), and ratio of Pao2and Fio2less than 100 at ICU admission (odds ratio = 1.96 [1.27-3.02]; p = 0.0002) were independently associated with intubation rate. Day-28 mortality was independently associated with bacterial (odds ratio = 2.34 [1.10-4.97]; p = 0.03) or opportunistic infection (odds ratio = 4.96 [2.11-11.6]; p < 0.001), noninvasive ventilation use (odds ratio = 2.35 [1.35-4.09]; p = 0.003), Sequential Organ Failure Assessment score (odds ratio = 1.19 [1.10-1.28]; p < 0.001), and ratio of Pao2and Fio2less than 100 at ICU admission (odds ratio = 1.97 [1.26-3.09]; p = 0.003). High-flow nasal cannula oxygen use was neither associated with intubation nor mortality rates. Conclusions: Some clinical characteristics at ICU admission including etiology and severity of acute respiratory failure enable to, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

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