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Purpose To evaluate the impact of beam quality in terms of distal fall off DFO, 90 10 and lateral penumbra LP, 80 20 of single beam ocular proton therapy OPT and to derive resulting ideal requirements for future systems. Methods Nine different beam models with DFO varying between 1 and 4 mm and LP between 1 and 4 mm were created. Beam models were incorporated into the RayStation with RayOcular treatment planning system version 10 B RaySearch Laboratories, Stockholm, Sweden . Each beam model was applied for eight typical clinical cases, covering different sizes and locations of uveal melanoma. Plans with and without an additional wedge were created, resulting in 117 plans with a total prescribed median dose of 60 Gy RBE to the clinical target volume. Treatment plans were analyzed in terms of V20 V80 penumbra volume, D1 dose to 1 of the volume for optic disc and macula, optic nerve V30 volume receiving 30 Gy RBE , i.e., 50 of prescription , as well as average dose to lens and ciliary body. An LP dependent aperture margin was based on estimated uncertainties, ranging from 1.7 to 4.0 mm. Results V20 V80 showed a strong influence by LP, while DFO was less relevant. The optic disc D1 reached an extra dose of up to 3000 cGy RBE , comparing the defined technical limit of DFO LP 1 mm with DFO 3 mm LP 4 mm. The latter may result from a pencil beam scanning PBS system with static apertures. Plans employing a wedge showed an improvement for organs at risk sparing. Conclusion Plan quality is strongly influenced by initial beam parameters. The impact of LP is more pronounced when compared to DFO. The latter becomes important in the treatment of posterior tumors near the macula, optic disc or optic nerve. The plan quality achieved by dedicated OPT nozzles in single or double scattering design might not be achievable with modified PBS systems

Background and purpose: As a part of the commissioning and quality assurance in proton beam therapy, lateral dose profiles and output factors have to be acquired. Such measurements can be performed with point detectors and are especially challenging in small fields or steep lateral penumbra regions as the detector's volume effect may lead to perturbations. To address this issue, this work aims to quantify and correct for such perturbations of six point detectors in small proton fields created via three different delivery techniques. Methods: Lateral dose profile and output measurements of three proton beam delivery techniques (pencil beam scanning, pencil beam scanning combined with collimators, passive scattering with collimators) were performed using high-resolution EBT3 films, a PinPoint 3D 31022 ionization chamber, a microSilicon diode 60023 and a microDiamond detector 60019 (all PTW Freiburg, Germany). Detector specific lateral dose response functions K(x,y) acting as the convolution kernel transforming the undisturbed dose distribution D(x,y) into the measured signal profiles M(x,y) were applied to quantify perturbations of the six investigated detectors in the proton fields and correct the measurements. A signal theoretical analysis in Fourier space of the dose distributions and detector's K(x,y) was performed to aid the understanding of the measurement process with regard to the combination of detector choice and delivery technique. Results: Quantification of the lateral penumbra broadening and signal reduction at the fields center revealed that measurements in the pencil beam scanning fields are only compromised slightly even by large volume ionization chambers with maximum differences in the lateral penumbra of 0.25 mm and 4% signal reduction at the field center. In contrast, radiation techniques with collimation are not accurately represented by the investigated detectors as indicated by a penumbra broadening up to 1.6 mm for passive scattering with collimators and 2.2 mm for pencil beam scanning with collimators. For a 3 mm diameter collimator field, a signal reduction at field center between 7.6% and 60.7% was asserted. Lateral dose profile measurements have been corrected via deconvolution with the corresponding K(x,y) to obtain the undisturbed D(x,y). Corrected output ratios of the passively scattered collimated fields obtained for the microDiamond, microSilicon and PinPoint 3D show agreement better than 0.9% (one standard deviation) for the smallest field size of 3 mm. Conclusion: Point detector perturbations in small proton fields created with three delivery techniques were quantified and found to be especially pronounced for collimated small proton fields with steep dose gradients. Among all investigated detectors, the microSilicon diode showed the smallest perturbations. The correction strategies based on detector's K(x,y) were found suitable for obtaining unperturbed lateral dose profiles and output factors. Approximation of K(x,y) by considering only the geometrical averaging effect has been shown to provide reasonable prediction of the detector's volume effect. The findings of this work may be used to guide the choice of point detectors in various proton fields and to contribute toward the development of a code of practice for small field proton dosimetry. in press

This experimental study aims to measure nuclear cross sections from natC and 27Al which serve as reference targets regarding radioactivation in proton therapy. Graphite and aluminum foils were activated in broad, quasi-monochromatic proton fields generated with the pencil-beam scanning technique. The γ-emissions were analyzed subsequently in a nearby γ-ray spectrometry facility designed for low-level radioactivity measurements. The number of incident protons was measured with a Faraday Cup. A detailed evaluation of the uncertainties was performed. The cross section for the natC(p,x)11C reaction at 100 MeV is (70.2 ± 1.6 (sys.) ± 0.2 (stat.)) mb. The production cross sections from 27Al at 100 MeV are (19.9 ± 0.4 ± 0.3) mb for 22Na and ( 11.5 ± 0.3 ± 0.1 ) mb for 24Na. The systematic uncertainties contribute 2.0%–2.4% of the quoted uncertainties ( k = 1 ) of cross sections. Concluding, radioactivation cross sections were measured with proton fields in a clinically commissioned environment. The measured activation cross sections from aluminum used for monitoring of the proton fluence agree with the averaged values compiled in nuclear reaction data bases. For proton-induced radioactivation from carbon the chemical purity of the target strongly affects the experimental results. The cross section for the production of 11C derived from a measurement with a high-purity graphite target is in line with the largest cross section obtained in prior studies.

Poster-Abstract

Purpose An independent dosimetry audit based on end-to-end testing of the entire chain of radiation therapy delivery is highly recommended to ensure consistent treatments among proton therapy centers. This study presents an auditing methodology developed by the MedAustron Ion Beam Therapy Center (Austria) in collaboration with the National Physical Laboratory (UK) and audit results for five scanned proton beam therapy facilities in Europe. Methods The audit procedure used a homogeneous and an anthropomorphic head phantom. The phantoms were loaded either with an ionization chamber or with alanine pellets and radiochromic films. Homogeneously planned doses of 10 Gy were delivered to a box-like target volume in the homogeneous phantom and to two clinical scenarios with increasing complexity in the head phantom. Results For all tests the mean of the local differences of the absolute dose to water determined with the alanine pellets compared to the predicted dose from the treatment planning system installed at the audited institution was determined. The mean value taken over all tests performed was −0.1 ± 1.0%. The measurements carried out with the ionization chamber were consistent with the dose determined by the alanine pellets with a mean deviation of −0.5 ± 0.6%. Conclusion The developed dosimetry audit method was successfully applied at five proton centers including various “turn-key” Cyclotron solutions by IBA, Varian and Mevion. This independent audit with extension to other tumour sites and use of the correspondent anthropomorphic phantoms may be proposed as part of a credentialing procedure for future clinical trials in proton beam therapy.

Purpose To commission the treatment planning system (TPS) RayStation for proton therapy including beam models for spot scanning and for uniform scanning. Methods Tests consist of procedures from ESTRO booklet number 7, the German DIN for constancy checks of TPSs, and extra tests checking the dose perturbation function. The dose distributions within patients were verified in silico by a comparison of 65 clinical treatment plans with the TPS XiO. Dose-volume parameters, dose differences, and three-dimensional gamma-indices serve as measures of similarity. The monthly constancy checks of Raystation have been automatized with a script. Results The basic functionality of the software complies with ESTRO booklet number 7. For a few features minor enhancements are suggested. The dose distribution in RayStation agrees with the calculation in XiO. This is supported by a gamma-index (3 mm/3%) pass rate of >98.9% (median over 59 plans) for the volume within the 20% isodose line and a difference of V 95 of the PTV (median over 59 plans). If spot scanning is used together with a range shifter, the dose level calculated by RayStation can be off by a few percent. Conclusions RayStation can be used for the creation of clinical proton treatment plans. Compared to XiO RayStation has an improved modelling of the lateral dose fall-off in passively delivered fields. For spot scanning fields with range shifter blocks an empirical adjustment of monitor units is required. The computation of perturbed doses also allows the evaluation of the robustness of a treatment plan.

Aim To verify the consistency of dose and range measurement in an interinstitution comparison among proton therapy institutions in Germany which use the pencil-beam scanning technique. Methods Following a peer-to-peer approach absorbed dose and range have been intercompared in several missions at two hosting centers with two or three visiting physics teams of participating institutions using their own dosimetry equipment. A meta-analysis has been performed integrating the results of the individual missions. Dose has been determined with ionization chambers according to the dosimetry protocol IAEA TRS-398. For determination of the depth of the distal 80% dose the teams used either a scanning water phantom, a variable water column or a multi-layer ionization chamber. Results The systematic deviation between measured doses of the participating institutions is less than 1%. Ranges differ systematically less than 0.4 mm. Conclusions The match of measured dose and range is better than expected from the respective uncertainties. As all physics teams agree on the assessment of absorbed dose and range, an important prerequisite for a start of joint clinical studies is fulfilled.

Acquisition of quasi‐monoenergetic ("pristine") depth‐dose curves is an essential task in the frame of commissioning and quality assurance of a proton therapy treatment head. For pencil beam scanning delivery modes this is often accomplished by measuring the integral ionization in a plane perpendicular to the axis of an unscanned beam. We focus on the evaluation of three integral detectors: two of them are plane‐parallel ionization chambers with an effective radius of 4.1 cm and 6.0 cm, respectively, mounted in a scanning water phantom. The third integral detector is a 6.0 cm radius multilayer ionization chamber. The experimental results are compared with the corresponding measurements under broad field conditions, which are performed with a small radius plane‐parallel chamber and a small radius multilayer ionization chamber. We study how a measured depth‐dose curve of a pristine proton field depends on the detection device, by evaluating the shape of the depth‐dose curve, the relative charge collection efficiency, and intercomparing measured ranges. Our results show that increasing the radius of an integral chamber from 4.1 cm to 6.0 cm increases the collection efficiency by 0%–3.5% depending on beam energy and depth. Ranges can be determined by the large electrode multilayer ionization chamber with a typical uncertainty of 0.4 mm on a routine basis. The large electrode multilayer ionization chamber exhibits a small distortion in the Bragg Peak region. This prohibits its use for acquisition of base data, but is tolerable for quality assurance. The good range accuracy and the peak distortion are characteristics of the multilayer ionization chamber design, as shown by the direct comparison with the small electrode counterpart. PACS number: 87.55.Qr

We present here a novel method for using a single device in the daily quality assurance (QA) of pencil beam scanning (PBS) proton beams and an improved method for uniform scanning (US). The device can be used to measure the spot position, spot sigma, range, output, collinearity of the X‐ray system and proton beam, and to QA the first scatterers and a number of other imaging and mechanical checks. We have performed the daily QA according to this procedure for more than six months in both a PBS gantry and a US gantry. All of the tests were found to be sensitive and accurate enough to determine if the property being tested is within the tolerance. The output has remained within the ±2% tolerance, with the majority of measurements within ±1%, and the range was within ±0.5mm. The collinearity of the proton beam in both gantries is within the ±1mm tolerance in both X and Y directions for all measurements. A novel procedure to measure the functionality of the first scatterers in the US gantry is included in the QA procedure. It was found to be sensitive enough to pick up the thinnest scatterer of 0.6 mm in both possible failure methods — when it always remains in the beam or in the case when it never goes into the beam. The daily QA procedure presented here can be implemented at PBS or US proton therapy centers with a minimal outlay for equipment and setup time. The procedure can be performed in less than 30 min, and has been found to be accurate and reliable enough for the QA of a proton therapy gantry before patient treatment every day. PACS number: 87.55.Qr