18 results on '"Bendok B"'
Search Results
2. 5-ALA for fluorescence-guided resections of newly diagnosed or recurrent meningiomas - the NXDC-MEN-301 study
- Author
-
Suero-Molina, E, Bendok, B, Vogelbaum, M, Cox, A, Wyse, J, Sackmann, M, Ezrin, A, Stummer, W, Suero-Molina, E, Bendok, B, Vogelbaum, M, Cox, A, Wyse, J, Sackmann, M, Ezrin, A, and Stummer, W
- Published
- 2022
3. Additional file 2 of Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-arm, multicenter trial
- Author
-
Carlson, Andrew P., Slot, Emma M. H., van Doormaal, Tristan P. C., Voormolen, E. H. J., Dankbaar, J. W., Depauw, P., Brouwers, B., Germans, M. R., Baert, E., Vandersteene, J., Freyschlag, C. F., Freyschlag, J., Thomé, C., Zenga, F., Penner, F., Abdulazim, A., Sabel, M., Rapp, M., Beez, T., Zuccarello, M., Sauvageau, E., Abdullah, K., Welch, B., Langer, D., Ellis, J., Dehdashti, A., VanGompel, J., Bendok, B., Chaichana, K., Liu, J., Dogan, A., Lim, M. K., and Hayden, M. G.
- Abstract
Additional file 2: DMC Charter.
- Published
- 2022
- Full Text
- View/download PDF
4. Additional file 1 of Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-arm, multicenter trial
- Author
-
Carlson, Andrew P., Slot, Emma M. H., van Doormaal, Tristan P. C., Voormolen, E. H. J., Dankbaar, J. W., Depauw, P., Brouwers, B., Germans, M. R., Baert, E., Vandersteene, J., Freyschlag, C. F., Freyschlag, J., Thomé, C., Zenga, F., Penner, F., Abdulazim, A., Sabel, M., Rapp, M., Beez, T., Zuccarello, M., Sauvageau, E., Abdullah, K., Welch, B., Langer, D., Ellis, J., Dehdashti, A., VanGompel, J., Bendok, B., Chaichana, K., Liu, J., Dogan, A., Lim, M. K., and Hayden, M. G.
- Abstract
Additional file 1: SPIRIT checklist.
- Published
- 2022
- Full Text
- View/download PDF
5. Functional and Physical Outcomes following Use of a Flexible CO2Laser Fiber and Bipolar Electrocautery in Close Proximity to the Rat Sciatic Nerve with Correlation to an In Vitro Thermal Profile Model
- Author
-
Robinson, A. M., primary, Fishman, A. J., additional, Bendok, B. R., additional, and Richter, C.-P., additional
- Published
- 2015
- Full Text
- View/download PDF
6. Functional and Physical Outcomes following Use of a Flexible CO2 Laser Fiber and Bipolar Electrocautery in Close Proximity to the Rat Sciatic Nerve with Correlation to an In Vitro Thermal Profile Model.
- Author
-
Robinson, A. M., Fishman, A. J., Bendok, B. R., and Richter, C.-P.
- Subjects
ELECTROCOAGULATION (Medicine) ,ANIMAL experimentation ,BIOLOGICAL models ,HISTOLOGY ,RATS ,RESEARCH funding ,SCIATIC nerve ,STATISTICS ,DATA analysis ,IN vitro studies - Abstract
This study compared functional and physical collateral damage to a nerve when operating a Codman MALIS Bipolar Electrosurgical System CMC-III or a CO
2 laser coupled to a laser, with correlation to an in vitro model of heating profiles created by the devices in thermochromic ink agarose. Functional damage of the rat sciatic nerve after operating the MALIS or CO2 laser at various power settings and proximities to the nerve was measured by electrically evoked nerve action potentials, and histology of the nerve was used to assess physical damage. Thermochromic ink dissolved in agarose was used to model the spatial and temporal profile of the collateral heating zone of the electrosurgical system and the laser ablation cone. We found that this laser can be operated at 2 W directly above the nerve with minimal damage, while power settings of 5 W and 10 W resulted in acute functional and physical nerve damage, correlating with the maximal heating cone in the thermochromic ink model. MALIS settings up to 40 (11 W) did not result in major functional or physical nerve damage until the nerve was between the forceps tips, correlating with the hottest zone, localized discretely between the tips. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
7. Characterization of cerebral aneurysms using 4D FLOW MRI
- Author
-
Schnell Susanne, Ansari Sameer A, Vakil Parmede, Hurley Michael, Carr James, Batjer Hunt, Bendok Bernard R, Carroll Timothy J, and Markl Michael
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2012
- Full Text
- View/download PDF
8. Building and implementing an institutional registry for a data-driven national neurosurgical practice: experience from a multisite medical center.
- Author
-
Bydon M, Goyal A, Biedermann A, Canoy Illies AJ, Paul T, Ghaith AK, Bendok B, Quiñones-Hinojosa A, Spinner RJ, and Meyer FB
- Subjects
- Humans, Neurosurgical Procedures, Registries, Surveys and Questionnaires, Hospitals, Neurosurgery
- Abstract
In an era when healthcare "value" remains a much-emphasized concept, measuring and reporting the quality of neurosurgical care and costs remains a challenge for large multisite health systems. Ensuring cohesion in outcomes across multiple sites is important to the development of a holistic competitive marketing strategy that seeks to promote "brand" performance characterized by a superior quality of patient care. This requires mechanisms for data collection and development of a single uniform outcomes measurement system site wide. Operationalizing a true multidisciplinary effort in this space requires intersection of a vast array of information technology and administrative resources along with the neurosurgeons who provide subject-matter expertise relevant to patient care. To measure neurosurgical quality and safety as well as improve payor contract negotiations, a practice analytics dashboard was created to allow summary visualization of operational indicators such as case volumes, quality outcomes, and relative value units and financial indicators such as total hospital costs and charges in order to provide a comprehensive overview of the "value" of surgical care. The current version of the dashboard summarizes these metrics by site, surgeon, and procedure for nearly 30,000 neurosurgical procedures that have been logged into the Mayo Clinic Enterprise Neurosurgery Registry since transition to the Epic electronic health record (EHR) system. In this article, the authors sought to review their experience in launching this EHR-linked data-driven neurosurgical practice initiative across a large, national multisite academic medical center.
- Published
- 2021
- Full Text
- View/download PDF
9. Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies.
- Author
-
Hoxworth JM, Eschbacher JM, Gonzales AC, Singleton KW, Leon GD, Smith KA, Stokes AM, Zhou Y, Mazza GL, Porter AB, Mrugala MM, Zimmerman RS, Bendok BR, Patra DP, Krishna C, Boxerman JL, Baxter LC, Swanson KR, Quarles CC, Schmainda KM, and Hu LS
- Subjects
- Adult, Aged, Brain Neoplasms pathology, Female, Glioma pathology, Humans, Image Interpretation, Computer-Assisted methods, Magnetic Resonance Imaging methods, Male, Middle Aged, Radiation Injuries diagnostic imaging, Radiation Injuries pathology, Tumor Burden, Brain Neoplasms diagnostic imaging, Glioma diagnostic imaging, Image Interpretation, Computer-Assisted standards, Magnetic Resonance Imaging standards, Neuroimaging methods
- Abstract
Background and Purpose: Perfusion MR imaging measures of relative CBV can distinguish recurrent tumor from posttreatment radiation effects in high-grade gliomas. Currently, relative CBV measurement requires normalization based on user-defined reference tissues. A recently proposed method of relative CBV standardization eliminates the need for user input. This study compares the predictive performance of relative CBV standardization against relative CBV normalization for quantifying recurrent tumor burden in high-grade gliomas relative to posttreatment radiation effects., Materials and Methods: We recruited 38 previously treated patients with high-grade gliomas (World Health Organization grades III or IV) undergoing surgical re-resection for new contrast-enhancing lesions concerning for recurrent tumor versus posttreatment radiation effects. We recovered 112 image-localized biopsies and quantified the percentage of histologic tumor content versus posttreatment radiation effects for each sample. We measured spatially matched normalized and standardized relative CBV metrics (mean, median) and fractional tumor burden for each biopsy. We compared relative CBV performance to predict tumor content, including the Pearson correlation ( r ), against histologic tumor content (0%-100%) and the receiver operating characteristic area under the curve for predicting high-versus-low tumor content using binary histologic cutoffs (≥50%; ≥80% tumor)., Results: Across relative CBV metrics, fractional tumor burden showed the highest correlations with tumor content (0%-100%) for normalized ( r = 0.63, P < .001) and standardized ( r = 0.66, P < .001) values. With binary cutoffs (ie, ≥50%; ≥80% tumor), predictive accuracies were similar for both standardized and normalized metrics and across relative CBV metrics. Median relative CBV achieved the highest area under the curve (normalized = 0.87, standardized = 0.86) for predicting ≥50% tumor, while fractional tumor burden achieved the highest area under the curve (normalized = 0.77, standardized = 0.80) for predicting ≥80% tumor., Conclusions: Standardization of relative CBV achieves similar performance compared with normalized relative CBV and offers an important step toward workflow optimization and consensus methodology., (© 2020 by American Journal of Neuroradiology.)
- Published
- 2020
- Full Text
- View/download PDF
10. A Multicenter Pilot Study on the Clinical Utility of Computational Modeling for Flow-Diverter Treatment Planning.
- Author
-
Chong BW, Bendok BR, Krishna C, Sattur M, Brown BL, Tawk RG, Miller DA, Rangel-Castilla L, Babiker H, Frakes DH, Theiler A, Cloft H, Kallmes D, and Lanzino G
- Subjects
- Female, Humans, Male, Pilot Projects, Software, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation methods, Computer Simulation, Intracranial Aneurysm surgery
- Abstract
Background and Purpose: Selection of the correct flow-diverter size is critical for cerebral aneurysm treatment success, but it remains challenging due to the interplay of device size, anatomy, and deployment. Current convention does not address these challenges well. The goals of this pilot study were to determine whether computational modeling improves flow-diverter sizing over current convention and to validate simulated deployments., Materials and Methods: Seven experienced neurosurgeons and interventional neuroradiologists used computational modeling to prospectively plan 19 clinical interventions. In each patient case, physicians simulated 2-4 flow-diverter sizes that were under consideration based on preprocedural imaging. In addition, physicians identified a preferred device size using the current convention. A questionnaire on the impact of computational modeling on the procedure was completed immediately after treatment. Rotational angiography image data were acquired after treatment and compared with flow-diverter simulations to validate the output of the software platform., Results: According to questionnaire responses, physicians found the simulations useful for treatment planning, and they increased their confidence in device selection in 94.7% of cases. After viewing the simulations results, physicians selected a device size that was different from the original conventionally planned device size in 63.2% of cases. The average absolute difference between clinical and simulated flow-diverter lengths was 2.1 mm. In 57% of cases, average simulated flow-diverter diameters were within the measurement uncertainty of clinical flow-diverter diameters., Conclusions: Physicians found computational modeling to be an impactful and useful tool for flow-diverter treatment planning. Validation results showed good agreement between simulated and clinical flow-diverter diameters and lengths., (© 2019 by American Journal of Neuroradiology.)
- Published
- 2019
- Full Text
- View/download PDF
11. Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning.
- Author
-
Hu LS, Yoon H, Eschbacher JM, Baxter LC, Dueck AC, Nespodzany A, Smith KA, Nakaji P, Xu Y, Wang L, Karis JP, Hawkins-Daarud AJ, Singleton KW, Jackson PR, Anderies BJ, Bendok BR, Zimmerman RS, Quarles C, Porter-Umphrey AB, Mrugala MM, Sharma A, Hoxworth JM, Sattur MG, Sanai N, Koulemberis PE, Krishna C, Mitchell JR, Wu T, Tran NL, Swanson KR, and Li J
- Subjects
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Brain Neoplasms diagnostic imaging, Brain Neoplasms pathology, Glioblastoma diagnostic imaging, Glioblastoma pathology, Machine Learning, Neuroimaging methods
- Abstract
Background and Purpose: MR imaging-based modeling of tumor cell density can substantially improve targeted treatment of glioblastoma. Unfortunately, interpatient variability limits the predictive ability of many modeling approaches. We present a transfer learning method that generates individualized patient models, grounded in the wealth of population data, while also detecting and adjusting for interpatient variabilities based on each patient's own histologic data., Materials and Methods: We recruited patients with primary glioblastoma undergoing image-guided biopsies and preoperative imaging, including contrast-enhanced MR imaging, dynamic susceptibility contrast MR imaging, and diffusion tensor imaging. We calculated relative cerebral blood volume from DSC-MR imaging and mean diffusivity and fractional anisotropy from DTI. Following image coregistration, we assessed tumor cell density for each biopsy and identified corresponding localized MR imaging measurements. We then explored a range of univariate and multivariate predictive models of tumor cell density based on MR imaging measurements in a generalized one-model-fits-all approach. We then implemented both univariate and multivariate individualized transfer learning predictive models, which harness the available population-level data but allow individual variability in their predictions. Finally, we compared Pearson correlation coefficients and mean absolute error between the individualized transfer learning and generalized one-model-fits-all models., Results: Tumor cell density significantly correlated with relative CBV ( r = 0.33, P < .001), and T1-weighted postcontrast ( r = 0.36, P < .001) on univariate analysis after correcting for multiple comparisons. With single-variable modeling (using relative CBV), transfer learning increased predictive performance ( r = 0.53, mean absolute error = 15.19%) compared with one-model-fits-all ( r = 0.27, mean absolute error = 17.79%). With multivariate modeling, transfer learning further improved performance ( r = 0.88, mean absolute error = 5.66%) compared with one-model-fits-all ( r = 0.39, mean absolute error = 16.55%)., Conclusions: Transfer learning significantly improves predictive modeling performance for quantifying tumor cell density in glioblastoma., (© 2019 by American Journal of Neuroradiology.)
- Published
- 2019
- Full Text
- View/download PDF
12. Evaluation of 4D vascular flow and tissue perfusion in cerebral arteriovenous malformations: influence of Spetzler-Martin grade, clinical presentation, and AVM risk factors.
- Author
-
Wu C, Ansari SA, Honarmand AR, Vakil P, Hurley MC, Bendok BR, Carr J, Carroll TJ, and Markl M
- Subjects
- Adult, Dominance, Cerebral physiology, Female, Humans, Intracranial Arteriovenous Malformations classification, Intracranial Arteriovenous Malformations diagnosis, Male, Microcirculation physiology, Middle Aged, Risk Factors, Angiography, Digital Subtraction methods, Blood Flow Velocity physiology, Cerebral Angiography methods, Cerebrovascular Circulation physiology, Image Interpretation, Computer-Assisted methods, Imaging, Three-Dimensional methods, Intracranial Arteriovenous Malformations physiopathology, Magnetic Resonance Angiography methods
- Abstract
Background and Purpose: The role of intracranial hemodynamics in the pathophysiology and risk stratification of brain AVMs remains poorly understood. The purpose of this study was to assess the influence of Spetzler-Martin grade, clinical history, and risk factors on vascular flow and tissue perfusion in cerebral AVMs., Materials and Methods: 4D flow and perfusion MR imaging was performed in 17 patients with AVMs. Peak velocity and blood flow were quantified in AVM feeding and contralateral arteries, draining veins, and the straight sinus. Regional perfusion ratios (CBF, CBV, and MTT) were calculated between affected and nonaffected hemispheres., Results: Regarding flow parameters, high-grade AVMs (Spetzler-Martin grade of >2) demonstrated significantly increased peak velocity and blood flow in the major feeding arteries (P < .001 and P = .004) and straight sinus (P = .003 and P = .012) and increased venous draining flow (P = .001). The Spetzler-Martin grade significantly correlated with cumulative feeding artery flow (r = 0.85, P < .001) and draining vein flow (r = 0.80, P < .001). Regarding perfusion parameters, perinidal CBF and CBV ratios were significantly lower (P < .001) compared with the remote ratios and correlated negatively with cumulative feeding artery flow (r = -0.60, P = .014 and r = -0.55, P = .026) and draining vein flow (r = -0.60, P = .013 and r = -0.56, P = .025). Multiple regression analysis revealed no significant association of AVM flow or perfusion parameters with clinical presentation (rupture and seizure history) and AVM risk factors., Conclusions: Macrovascular flow was significantly associated with increasing Spetzler-Martin grade and correlated with perinidal microvascular perfusion in cerebral AVMs. Future longitudinal studies are needed to evaluate the potential of comprehensive cerebral flow and perfusion MR imaging for AVM risk stratification., (© 2015 by American Journal of Neuroradiology.)
- Published
- 2015
- Full Text
- View/download PDF
13. Quantifying Intracranial Aneurysm Wall Permeability for Risk Assessment Using Dynamic Contrast-Enhanced MRI: A Pilot Study.
- Author
-
Vakil P, Ansari SA, Cantrell CG, Eddleman CS, Dehkordi FH, Vranic J, Hurley MC, Batjer HH, Bendok BR, and Carroll TJ
- Subjects
- Adult, Aged, Contrast Media, Female, Humans, Logistic Models, Male, Middle Aged, Observer Variation, Pilot Projects, Risk Assessment, Risk Factors, Capillary Permeability, Intracranial Aneurysm pathology, Magnetic Resonance Imaging methods
- Abstract
Background and Purpose: Pathological changes in the intracranial aneurysm wall may lead to increases in its permeability; however the clinical significance of such changes has not been explored. The purpose of this pilot study was to quantify intracranial aneurysm wall permeability (K(trans), VL) to contrast agent as a measure of aneurysm rupture risk and compare these parameters against other established measures of rupture risk. We hypothesized K(trans) would be associated with intracranial aneurysm rupture risk as defined by various anatomic, imaging, and clinical risk factors., Materials and Methods: Twenty-seven unruptured intracranial aneurysms in 23 patients were imaged with dynamic contrast-enhanced MR imaging, and wall permeability parameters (K(trans), VL) were measured in regions adjacent to the aneurysm wall and along the paired control MCA by 2 blinded observers. K(trans) and VL were evaluated as markers of rupture risk by comparing them against established clinical (symptomatic lesions) and anatomic (size, location, morphology, multiplicity) risk metrics., Results: Interobserver agreement was strong as shown in regression analysis (R(2) > 0.84) and intraclass correlation (intraclass correlation coefficient >0.92), indicating that the K(trans) can be reliably assessed clinically. All intracranial aneurysms had a pronounced increase in wall permeability compared with the paired healthy MCA (P < .001). Regression analysis demonstrated a significant trend toward an increased K(trans) with increasing aneurysm size (P < .001). Logistic regression showed that K(trans) also predicted risk in anatomic (P = .02) and combined anatomic/clinical (P = .03) groups independent of size., Conclusions: We report the first evidence of dynamic contrast-enhanced MR imaging-modeled contrast permeability in intracranial aneurysms. We found that contrast agent permeability across the aneurysm wall correlated significantly with both aneurysm size and size-independent anatomic risk factors. In addition, K(trans) was a significant and size-independent predictor of morphologically and clinically defined high-risk aneurysms., (© 2015 by American Journal of Neuroradiology.)
- Published
- 2015
- Full Text
- View/download PDF
14. Functional and physical outcomes following use of a flexible CO2 laser fiber and bipolar electrocautery in close proximity to the rat sciatic nerve with correlation to an in vitro thermal profile model.
- Author
-
Robinson AM, Fishman AJ, Bendok BR, and Richter CP
- Subjects
- Animals, Electrocoagulation methods, Female, Fiber Optic Technology methods, Laser Therapy methods, Lasers, Male, Rats, Surgical Instruments, Carbon Dioxide therapeutic use, Lasers, Gas therapeutic use, Sciatic Nerve surgery
- Abstract
This study compared functional and physical collateral damage to a nerve when operating a Codman MALIS Bipolar Electrosurgical System CMC-III or a CO2 laser coupled to a laser, with correlation to an in vitro model of heating profiles created by the devices in thermochromic ink agarose. Functional damage of the rat sciatic nerve after operating the MALIS or CO2 laser at various power settings and proximities to the nerve was measured by electrically evoked nerve action potentials, and histology of the nerve was used to assess physical damage. Thermochromic ink dissolved in agarose was used to model the spatial and temporal profile of the collateral heating zone of the electrosurgical system and the laser ablation cone. We found that this laser can be operated at 2 W directly above the nerve with minimal damage, while power settings of 5 W and 10 W resulted in acute functional and physical nerve damage, correlating with the maximal heating cone in the thermochromic ink model. MALIS settings up to 40 (11 W) did not result in major functional or physical nerve damage until the nerve was between the forceps tips, correlating with the hottest zone, localized discretely between the tips.
- Published
- 2015
- Full Text
- View/download PDF
15. Intracranial 4D flow MRI: toward individualized assessment of arteriovenous malformation hemodynamics and treatment-induced changes.
- Author
-
Ansari SA, Schnell S, Carroll T, Vakil P, Hurley MC, Wu C, Carr J, Bendok BR, Batjer H, and Markl M
- Subjects
- Adult, Cerebral Arteries pathology, Cerebral Veins pathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index, Young Adult, Cerebrovascular Circulation physiology, Embolization, Therapeutic methods, Hemodynamics physiology, Imaging, Three-Dimensional methods, Intracranial Arteriovenous Malformations pathology, Intracranial Arteriovenous Malformations physiopathology, Intracranial Arteriovenous Malformations therapy, Magnetic Resonance Angiography methods
- Abstract
Background and Purpose: Arteriovenous malformations are an important etiology of hemorrhagic stroke. However, current imaging modalities and risk do not provide insights into individual AVM hemodynamics and its role in pathophysiology. The aims of this study are to determine whether intracranial 4D flow MR imaging can provide insights into arteriovenous malformation hemodynamics independent of the Spetzler-Martin grade and to report the changes in flow observed during staged embolization., Materials and Methods: Intracranial 3D blood flow was assessed in 20 patients with AVM (age = 39 ± 15 years, Spetzler-Martin grade ranging from 1-4) with the use of 4D flow MR imaging (temporal resolution = 45 ms, spatial resolution = [1.2-1.6mm](3)). AVM hemodynamics were visualized by means of time-integrated 3D pathlines depicting the AVM arterial feeding and venous draining patterns over the cardiac cycle. Analysis included the grading of feeding and draining velocities on a 3-point scale (0 = low <25 cm/s, 1 = medium <50 cm/s, 2 = high >50 cm/s). For 4 of 20 patients undergoing 4D flow MR imaging follow-up after staged embolization, peak velocities were quantified in arterial feeders, draining veins, the sagittal sinus, and contralateral arteries., Results: In 50% of the cases with Spetzler-Martin grade >2, heterogeneous flow (velocity grade differences >1) was found across arteries and veins. Velocities in draining veins increased from Spetzler-Martin grade = 1 (grading = 0.5 ± 0.6) to Spetzler-Martin grade ≥3 (1.1 ± 0.6), whereas arterial velocities were similar (1.7 ± 0.6 versus 1.5 ± 0.6). In the postembolization subgroup of 4 patients, 4D flow MR imaging demonstrated successively more compact AVM and redistribution of velocities. Changes in arterial and venous velocities during treatment were highly different among individuals., Conclusions: Spetzler-Martin grade does not reflect differences in 3D AVM arterial and venous hemodynamics, and an individual assessment of AVM hemodynamics may be needed for improved lesion characterization. Four-dimensional flow MR imaging may have the potential to monitor and guide embolization treatment planning.
- Published
- 2013
- Full Text
- View/download PDF
16. Preoperative Onyx embolization of aggressive vertebral hemangiomas.
- Author
-
Hurley MC, Gross BA, Surdell D, Shaibani A, Muro K, Mitchell CM, Doppenberg EM, and Bendok BR
- Subjects
- Adult, Female, Humans, Lumbar Vertebrae, Male, Treatment Outcome, Dimethyl Sulfoxide therapeutic use, Embolization, Therapeutic methods, Hemangioma therapy, Polyvinyls therapeutic use, Spinal Neoplasms therapy
- Abstract
We report the first use of Onyx in the embolization of spinal tumors in 2 cases of aggressive vertebral hemangioma. In both cases, Onyx embolization provided effective preoperative tumor devascularization after the initial prolonged particulate embolization with Embospheres made little overall impact. Onyx enables a more rapid and visible embolization than particles and is less technically demanding than traditional liquid embolic agents, such as n-butyl cyanoacrylate.
- Published
- 2008
- Full Text
- View/download PDF
17. Cerebral cavernous malformations: clinical insights from genetic studies.
- Author
-
Mindea SA, Yang BP, Shenkar R, Bendok B, Batjer HH, and Awad IA
- Subjects
- Animals, Brain Neoplasms diagnosis, Brain Neoplasms physiopathology, Cerebral Veins abnormalities, Cerebral Veins pathology, Cerebral Veins physiopathology, Disease Models, Animal, Hemangioma, Cavernous, Central Nervous System diagnosis, Hemangioma, Cavernous, Central Nervous System physiopathology, Hispanic or Latino genetics, Humans, Inheritance Patterns genetics, Mice, Brain Neoplasms genetics, Genetic Predisposition to Disease, Hemangioma, Cavernous, Central Nervous System genetics
- Abstract
Familial disease is responsible for one third to one half of cerebral cavernous malformation (CCM) cases presenting to clinical attention. Much has been learned in the past decade about the genetics of these cases, which are all inherited in an autosomal dominant pattern, at three known chromosome loci. Unique features of inherited CCMs in Hispanic-Americans of Mexican descent have been described. The respective genes for each locus have been identified and preliminary observations on disease pathways and mechanisms are coming to light, including possible explanations for selectivity of neural milieu and relationships to endothelial layer abnormalities. Mechanisms of lesion genesis in cases of genetic predisposition are being investigated, with evidence to support a two-hit model emerging from somatic mutation screening of the lesions themselves and from lesion formation in transgenic murine models of the disease. Other information on potential inflammatory factors has emerged from differential gene expression studies. Unique phenotypic features of solitary versus familial cases have emerged: different associations with venous developmental anomaly and the exceptionally high penetrance rates that are found in inherited cases when high-sensitivity screening is performed with gradient echo magnetic resonance imaging. This information has changed the landscape of screening and counseling for patients and their families, and promises to lead to the development of new tools for predicting, explaining, and modifying disease behavior.
- Published
- 2006
- Full Text
- View/download PDF
18. Temporary balloon occlusion to test adequacy of collateral flow to the retina and tolerance for endovascular aneurysmal coiling.
- Author
-
Shaibani A, Khawar S, Bendok B, Walker M, Russell EJ, and Batjer HH
- Subjects
- Aneurysm therapy, Carotid Artery Diseases therapy, Carotid Artery, Internal, Female, Humans, Intracranial Aneurysm therapy, Middle Aged, Neck blood supply, Time Factors, Aneurysm physiopathology, Balloon Occlusion, Carotid Artery Diseases physiopathology, Collateral Circulation, Embolization, Therapeutic instrumentation, Intracranial Aneurysm physiopathology, Ophthalmic Artery, Retinal Vessels physiopathology
- Abstract
Two carotid ophthalmic artery aneurysms with incorporation of the artery into the neck were referred for endovascular assessment. Temporary balloon occlusion at the aneurysm neck was performed in an attempt to assess the adequacy of collateral flow to the retina. During inflation, the patients reported visual deterioration that resolved upon deflation, which indicates that collateral blood flow was insufficient. The patients were referred for surgical clipping to ensure preservation of the ophthalmic artery.
- Published
- 2004
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.