192 results on '"Baukrowitz, Thomas"'
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2. Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
3. Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
4. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier
5. Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.
6. Functional Conversion between A-Type and Delayed Rectifier K + Channels by Membrane Lipids
7. PIP$_2$ and PIP as Determinants for ATP Inhibition of K$_{ATP}$ Channels
8. Two Functionally Distinct Subsites for the Binding of Internal Blockers to the Pore of Voltage-Activated K + Channels
9. Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K$^+$ Channel
10. Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia
11. KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function
12. The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism
13. The pore structure and gating mechanism of K2P channels
14. RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels
15. Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
16. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel
17. Structural Basis for Gating of the Two-Pore Domain K+ (K2P) Channels TASK-1 and TALK-2
18. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis
19. Functional conversion between A-type and delayed rectifier [K.sup.+] channels by membrane lipids
20. Inward rectification in KATP channels: a pH switch in the pore
21. Characterisation of the Versatile Gating Behaviour in Talk-2 K2P Channels
22. Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
23. Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels
24. Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels
25. Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels
26. The inward rectification mechanism of the HERG cardiac potassium channel
27. The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels
28. A Pharmacological Masterkey Mechanism to Unlock the Selectivity Filter Gate in K+ Channels
29. Erratum: The pore structure and gating mechanism of K2P channels
30. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
31. Silver as a Probe of Selectivity Filter Gating in TREK-1 K2P Channels
32. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states
33. Liposome-Based in Vitro Biosynthesis of Two-Pore Domain Potassium Channels for Functional Studies
34. Polymodal Gating of the TREK-2 K2P Potassium Channel Involves Structurally Distinct Open States
35. A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels
36. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
37. Sensing the Electrochemical K+ Gradient: The Voltage Gating Mechanism in K2P Potassium Channels
38. Bidirectional control of Kir-channel activity by phosphoinositides and LC-acyl-CoA esters
39. Insights into the structural nature of the transition state in the Kir channel gating pathway
40. State-Dependent Network Connectivity Determines Gating in a K+ Channel
41. Structural and Thermodynamic Characterization of the Gating Pathway in a K+ Channel
42. A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels
43. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1
44. Structural and Mechanistic Insights into Gating of K2P Channels
45. A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore
46. Identification of Gating Mutations in the Trek-1 k2p Potassium Channel by Functional Complementation in K+ uptake Deficient Yeast
47. PIP2-Binding to an Open State Model of Kir1.1 Probed by Multiscale Biomolecular Simulations
48. Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel
49. A Structural Model of a Kir Channel in the Open State Derived from Mutagenic Scanning of the Pore Gating Energetics
50. TREK Channel Pore Probed by Cysteine Scanning Mutagenesis and Structural Modelling
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