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3 results on '"Bataini Jp"'

1. Treatment of supraglottic cancer by radical high dose radiotherapy

Author

Ennuyer A, Poncet P, N.A. Ghossein, and Bataini Jp

Subjects
Larynx, Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Supraglottic Cancer, Radiation failure, Surgery, Laryngectomy, Radiation therapy, Tracheotomy, medicine.anatomical_structure, Oncology, medicine, Advanced disease, business, Larynx neoplasm
Abstract

Megavoltage radiotherapy was used as a treatment in 218 patients with supraglottic cancer. Forty-five percent had positive nodes and 43% had extralaryngeal disease. Absolute 3- and 5-year survival for T1-T2 was 70 and 60%; for T3-T4 lesions it was 42 and 35%. Differences in survival between patients with negative nodes and those with mobile nodes was unremarkable. One percent recurred in the neck when there was no palpable node initially. Ninety-five percent of mobile nodes were controlled when the primary was cured. The most common failure site was the larynx. Neither subglottic extension nor specific sites of extralaryngeal involvement worsened the prognosis. Eight had major radiation complications, 1 fatal, 7 requiring tracheotomy. Twenty-five had surgery for recurrence, and 7 were salvaged. Our present policy is radiotherapy for early tumors, and for T4, if more than total laryngectomy is required. Surgery is reserved for radiation failure and often for advanced disease limited to larynx.

Published
1974
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2. Malignant gliomas treated after surgery by combination chemotherapy and delayed irradiation. Part I: Analysis of results.

Author

Poisson M, Pouillart P, Bataini JP, Mashaly R, Pertuiset BF, and Metzger J

Subjects
Adolescent, Adult, Aged, Cobalt Radioisotopes administration & dosage, Cobalt Radioisotopes therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy Dosage, Astrocytoma therapy, Brain Neoplasms therapy, Lomustine administration & dosage, Nitrosourea Compounds administration & dosage, Podophyllotoxin analogs & derivatives, Teniposide administration & dosage
Abstract

Forty-six patients with gliomas were introduced after surgery into a therapeutic programme of six cycles of combination chemotherapy with VM26 and CCNU, followed by delayed irradiation six months after surgery with an average dose of 5,800 rads. After irradiation the same preradiation chemotherapy was readministered for an average of four cycles. The results were compared to those from another group of 28 patients treated only by the same chemotherapy (CRC and C groups sucessively). Twelve patients (26%) died before irradiation in the CRC group, six patients (13%) had recurrences at the time of irradiation, and 28 patients (61%) had no clinical or radiological signs of recurrence at the time of irradiation. For the total of treated patients the median survival after surgery was 17 months, and 46% of the patients were surviving at 18 months. The percentage of survivors at 18 months was significantly more elevated in the group treated by combination chemotherapy and delayed irradiation than in a control group treated by the same combination chemotherapy alone. This result suggests that in approximately 50% of cases combination chemotherapy after surgery, and delayed irradiation six months after surgery, cumulated their effects on survival time.

Published
1979
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3. Malignant gliomas treated after surgery by combination chemotherapy and delayed radiation therapy. Part II. Tolerance to irradiation after chemotherapy.

Author

Poisson M, Hauw JJ, Pouillart P, Bataini JP, Mashaly R, Pertuiset BF, and Metzger J

Subjects
Drug Therapy, Combination, Humans, Lomustine administration & dosage, Neoplasm Recurrence, Local, Radiation Tolerance, Radiotherapy Dosage, Teniposide administration & dosage, Brain radiation effects, Brain Neoplasms therapy, Glioma therapy, Lomustine adverse effects, Nitrosourea Compounds adverse effects, Podophyllotoxin analogs & derivatives, Radiotherapy adverse effects, Teniposide adverse effects
Abstract

34 patients operated on for malignant gliomas were successively treated by combination chemotherapy with VM26 and CCNU and conventional radiation therapy with an average dosage of 5,800 Rads, six months after surgery. The general and haematological tolerance of delayed irradiation after chemotherapy was satisfactory. Twelve patients developed neurological complications during or after irradiation. The complications were early in 10 cases, and delayed in 2. They were probably due to tumour growth in five cases, and secondary to irradiation in seven. In four of the seven cases the preradiation chemotherapy seemed to potentiate the radiation effect on the central nervous system.

Published
1979
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