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1. Identification of bacterial posttranslational modifications that regulate antimicrobial resistance

Author

Barlow, Victoria

Abstract

Rapidly spreading antimicrobial resistance is one of the greatest threats to human health of our time. There exists many mechanisms by which bacteria evade destruction by antibiotics and various research is being conducted globally in an attempt to combat this alarming situation. A so far under-researched area is the hypothesised role of protein post-translational modifications in the regulation of antimicrobial resistance responses. This thesis identifies two proteins involved in antimicrobial resistance and known to undergo post-translational modification, then uses genetic code expansion and unnatural amino acid incorporation to characterise the effect of these modifications on protein function. The first protein is AdeT1, a component of a multi-drug efflux pump from the multidrug resistant pathogen Acinetobacter baumannii, which undergoes lysine propionylation at Lys280 in vivo. Here, such propionylation is shown to modulate function of the efflux pump in living cells, with the propionylated protein complex demonstrating increased ethidium bromide efflux. Further, cells producing propionylated AdeT1 required a 6-fold higher concentration of erythromycin to inhibit their growth compared to cells producing unmodified AdeT1. The second protein investigated is the DNA-binding protein HU from Escherichia coli, which undergoes acetylation at five lysine residues in vivo. The protein was characterised in DNA-binding assays in vitro, which revealed that protein acetylated at Lys86 has significantly lower affinity for DNA compared to its wildtype counterpart. The consequences of such altered binding on bacterial gene expression and antimicrobial resistance are contemplated. Together, the results presented here are in agreement with the known roles of post-translational modifications in modulating protein function and provide evidence toward a novel analysis of posttranslational modifications as regulatory components in antimicrobial resistance responses.

Published
2022

2. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Catherine, Amory, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau Cécile Magne, Caroline, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, Brière, François de la, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Izzo, Francesca, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Federico, Bilotta, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Bystrica, Banská, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela Pirtovšek, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, Serrano, Cristina González, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, García, Ernesto Martínez, Tormo de las Heras, Carolina, Montero, Pablo Troncoso, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Comas, Montserrat Suarez, Escribá, Francisco, Auli, Cristina, Pardo, Osvaldo Pérez, Biddle, Natalia Sierra, Castaño, Ceferina Suárez, Villalobos Rico, María Isabel, Muñoz, Susana Manrique, Martínez, Irene García, Estruch, Nuria Montferrer, Ortíz, Elena Vilardell, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet Wolfe, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano Scalia, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Engelhardt, Thomas, Hansen, Tom G., de Graaff, Jurgen C., and Virag, Katalin

Published
2022
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3. Research into land atmosphere interactions supports the Sustainable Development agenda

Author

Hayman, Garry, primary, Poulter, Benjamin, additional, Ghude, Sachin D., additional, Blyth, Eleanor, additional, Sinha, Vinayak, additional, Archibald, Sally, additional, Ashworth, Kirsti, additional, Barlow, Victoria, additional, Fares, Silvano, additional, Feig, Gregor, additional, Hiyama, Tetsuya, additional, Jin, Jiming, additional, Juhola, Sirkku, additional, Lee, Meehye, additional, Leuzinger, Sebastian, additional, Mahecha, Miguel D., additional, Meng, Xianhong, additional, Odee, David, additional, Purser, Gemma, additional, Sato, Hisashi, additional, Saxena, Pallavi, additional, Semeena, Valiyaveetil S., additional, Steiner, Allison, additional, Wang, Xuemei, additional, and Wolff, Stefan, additional

Published
2024
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5. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Kerovec Sorić, Ivana, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Nouette Gaulain, Karine, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cécile, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Brière, François, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Puric Racic, Selena, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Pirtovšek Štupnik, Špela, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, González Serrano, Cristina, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, Martínez García, Ernesto, Tormo de las Heras, Carolina, Troncoso Montero, Pablo, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Suarez Comas, Montserrat, Escribá, Francisco, Auli, Cristina, Pérez Pardo, Osvaldo, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Villalobos Rico, María Isabel, Manrique Muñoz, Susana, García Martínez, Irene, Montferrer Estruch, Nuria, Vilardell Ortíz, Elena, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Wolfe Barry, Juliet, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Scalia Catenacci, Stefano, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Virag, Katalin, and Engelhardt, Thomas

Published
2021
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6. Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, Rene, Cajkova, Petra, Mixa, Vladimir, Sedlačkova, Yvona, Knoppova, Lenka, Zlamalova (nee Květoňova), Alena, Vavřina, Martin, Žurek, Jiři, Hansen, Tom, Afshari, Arash, Bille, Anders B., Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Vali, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vahatalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Herve, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, Francois, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cecile, Petry, Lea, Ros, Lilica, Zang, Aurelien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurelien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Briere, Francois, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Loffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schafer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Scholer, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yucetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Sohle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Szekely, Edgar, Kosik, Nandor, Maraczi, Veronika, Schnur, Janos, Csillag, Judit, Gal, Janos, Gobl, Gergely, Hauser, Balazs, Petroczy, Andras, Tovishazi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria C., Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura B., Finamore, Simona A., Porro, Giuliana A., Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald R., Favarato, Moreno, Locatelli, Bruno G., Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der, Anouk, Dortmont, Knijff-van, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella M., Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger M., Isern, Erik R., Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Silvia, Patuleia, Maria Domingas, Esteves, Catarina C., Salgado, Helena, Santos, Maria J., Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyiri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanova, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela P., Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandstrom, Kerstin, Bengt, Sporre, Dorenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnstrom, Ann, Ponten, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bogli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Holzle, Martin, Hurni, Thomas, Johr, Martin, Anna-Ursina, Malar, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse C., Hatipoğlu, Zehra, Ozcengiz, Dilek, Erdost, Hale Aksu, Ocmen, Elvan, Olguner, Cimen, Ayanoglu, Hilmi, Dincer, Pelin C., Umuroglu, Tumay, Azizoglu, Mustafa, Birbicer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet W., Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano S., Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Virag, Katalin, Hansen, Tom G., Harlet, Pierre, Walker, Suellen M., de Graaff, Jurgen C., and Engelhardt, Thomas

Published
2021
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7. Research into land atmosphere interactions supports the Sustainable Development agenda

Author

Hayman, Garry, Poulter, Benjamin, Ghude, Sachin D., Blyth, Eleanor, Sinha, Vinayak, Archibald, Sally, Ashworth, Kirsti, Barlow, Victoria, Fares, Silvano, Feig, Gregor, Hiyama, Tetsuya, Jin, Jiming, Juhola, Sirkku, Lee, Meehye, Leuzinger, Sebastian, Mahecha, Miguel D., Meng, Xianhong, Odee, David, Purser, Gemma, Sato, Hisashi, Saxena, Pallavi, Semeena, Valiyaveetil S., Steiner, Allison, Wang, Xuemei, Wolff, Stefan, Hayman, Garry, Poulter, Benjamin, Ghude, Sachin D., Blyth, Eleanor, Sinha, Vinayak, Archibald, Sally, Ashworth, Kirsti, Barlow, Victoria, Fares, Silvano, Feig, Gregor, Hiyama, Tetsuya, Jin, Jiming, Juhola, Sirkku, Lee, Meehye, Leuzinger, Sebastian, Mahecha, Miguel D., Meng, Xianhong, Odee, David, Purser, Gemma, Sato, Hisashi, Saxena, Pallavi, Semeena, Valiyaveetil S., Steiner, Allison, Wang, Xuemei, and Wolff, Stefan

Abstract

Greenhouse gas emissions and land use change - from deforestation, forest degradation and agricultural intensification - are contributing to climate change and biodiversity loss. Important landbased strategies such as planting trees or growing bioenergy crops (with carbon capture and storage) are needed to achieve the goals of the Paris Climate Agreement and to enhance biodiversity. The integrated Land Ecosystems Atmospheric Processes Study (iLEAPS) is an international knowledge-exchange and capacity-building network, specialising in ecosystems and their role in controlling the exchange of water, energy and chemical compounds between the land surface and the atmosphere. We outline priority directions for land-atmosphere interaction research and its contribution to the sustainable development agenda.

Published
2024

10. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe

Author

Disma, Nicola, primary, Engelhardt, Thomas, additional, Hansen, Tom G., additional, de Graaff, Jurgen C., additional, Virag, Katalin, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Sorić, Ivana Kerovec, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Catherine, Amory, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Gaulain, Karine Nouette, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau Cécile Magne, Caroline, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, Brière, François de la, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Kaufmann, Jost, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Izzo, Francesca, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Federico, Bilotta, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Racic, Selena Puric, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Bystrica, Banská, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Štupnik, Špela Pirtovšek, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, Serrano, Cristina González, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, García, Ernesto Martínez, additional, Tormo de las Heras, Carolina, additional, Montero, Pablo Troncoso, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Comas, Montserrat Suarez, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pardo, Osvaldo Pérez, additional, Biddle, Natalia Sierra, additional, Castaño, Ceferina Suárez, additional, Villalobos Rico, María Isabel, additional, Muñoz, Susana Manrique, additional, Martínez, Irene García, additional, Estruch, Nuria Montferrer, additional, Ortíz, Elena Vilardell, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Riva, Thomas, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Barry, Juliet Wolfe, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Catenacci, Stefano Scalia, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

Published
2022
Full Text
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11. Measuring the Morphologic Response of Braided Rivers to Lateral Constriction

Author

Barlow, Victoria

Subjects
active width, channel pattern change, Braided river, braiding intensity, Physical and Environmental Geography, Geographic Information Sciences, lateral confinement, Canterbury Plains NZ
Abstract

The aim of this thesis is to understand the morphologic changes to a set of historically braided rivers that have been narrowed. Braided rivers from the agriculturally developed Canterbury Plains, New Zealand, were studied from a period prior to much development (mid-1900s) to the present. Narrowing of channels, decreased braiding intensity, and loss of braided planforms were determined based on aerial imagery, changing the geography of braiding along all rivers. Channel width and count were statistically correlated and show the predictability of braiding change based on narrowing. Reaches with initially wide channels require more narrowing to induce a simplification of braiding, while narrower reaches may be closer to a threshold of change and require less narrowing to transition. The implications of the results can be used in river management to create wide enough river corridors that allow the rivers to maintain their naturally braided planforms while mitigating flood risk.

Published
2022

12. Scoping a floods and droughts research infrastructure (FDRI): report for the FDRI community, May 2020 to January 2022

Author

Old, Gareth, Reynard, Nick, Rees, Gwyn, Coxon, Gemma, Wagener, Thorsten, Bloomfield, John, Buytaert, Wouter, Fry, Matthew, Barlow, Victoria, Spencer, Marcia, Badcock, Nichola, Smith, Rebecca, Old, Gareth, Reynard, Nick, Rees, Gwyn, Coxon, Gemma, Wagener, Thorsten, Bloomfield, John, Buytaert, Wouter, Fry, Matthew, Barlow, Victoria, Spencer, Marcia, Badcock, Nichola, and Smith, Rebecca

Abstract

This report has been produced to summarise the results of the floods and droughts research infrastructure scoping study for the interested community.

Published
2022

15. Corrigendum to ‘Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study’ (Br J Anaesth 2021; 126: 1173–81)

Author

Disma, Nicola, primary, Virag, Katalin, additional, Riva, Thomas, additional, Kaufmann, Jost, additional, Engelhardt, Thomas, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Kerovec Sorić, Ivana, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Nouette Gaulain, Karine, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau, Caroline, additional, Magne, Cécile, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, de la Brière, François, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Wolfler, Andrea, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Zanaboni, Clelia, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Bilotta, Federico, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Puric Racic, Selena, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Pirtovšek Štupnik, Špela, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, González Serrano, Cristina, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, Martínez García, Ernesto, additional, Tormo de las Heras, Carolina, additional, Troncoso Montero, Pablo, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Suarez Comas, Montserrat, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pérez Pardo, Osvaldo, additional, Sierra Biddle, Natalia, additional, Suárez Castaño, Ceferina, additional, Villalobos Rico, María Isabel, additional, Manrique Muñoz, Susana, additional, García Martínez, Irene, additional, Montferrer Estruch, Nuria, additional, Vilardell Ortíz, Elena, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Wolfe Barry, Juliet, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Scalia Catenacci, Stefano, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

Published
2021
Full Text
View/download PDF

16. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Author

Disma, Nicola, primary, Virag, Katalin, additional, Riva, Thomas, additional, Kaufmann, Jost, additional, Engelhardt, Thomas, additional, Habre, Walid, additional, Breschan, Christian, additional, Likar, Rudolf, additional, Platzer, Manuela, additional, Edelman, Isole, additional, Eger, Johanes, additional, Heschl, Stefan, additional, Messerer, Brigitte, additional, Vittinghof, Maria, additional, Kroess, Ruth, additional, Stichlberger, Martina, additional, Kahn, David, additional, Pirotte, Thierry, additional, Pregardien, Caroline, additional, Veyckemans, Francis, additional, Stevens, France, additional, Berghmans, Johan, additional, Bauters, Annemie, additional, De Baerdemaeker, Luc, additional, De Hert, Stefan, additional, Lapage, Koen, additional, Parashchanka, Aliaksandra, additional, Van Limmen, Jurgen, additional, Wyffels, Piet, additional, Lauweryns, Julie, additional, Najafi, Nadia, additional, Vundelinckx, Joris, additional, Butković, Diana, additional, Kerovec Sorić, Ivana, additional, Kralik, Sandra, additional, Markić, Ana, additional, Azman, Josip, additional, Markic, Josko, additional, Pupacic, Daniela, additional, Frelich, Michal, additional, Reimer, Petr, additional, Urbanec, René, additional, Cajková, Petra, additional, Mixa, Vladimír, additional, Sedláčková, Yvona, additional, Knoppová, Lenka, additional, Zlámalová (neé Květoňová), Alena, additional, Vavřina, Martin, additional, Žurek, Jiří, additional, Hansen, Tom, additional, Afshari, Arash, additional, Bille, Anders Bastholm, additional, Ellekvist, Marguerite, additional, Ilmoja, Mari-Liis, additional, Moor, Reet, additional, Kikas, Reet, additional, Väli, Merle, additional, Kallio, Kariantti, additional, Reponen, Elisa, additional, Suominen, Pertti, additional, Suvanto, Sami, additional, Vähätalo, Raisa, additional, Kokki, Hannu, additional, Kokki, Merja, additional, Harju, Jarkko, additional, Kokkonen, Miia, additional, Vieri, Jenni, additional, Manner, Tuula, additional, Amory, Catherine, additional, Ludot, Hugues, additional, Bert, Dina, additional, Godart, Juliette, additional, Laffargue, Anne, additional, Dupont, Hervé, additional, Urbina, Benjamin, additional, Baujard, Catherine, additional, Roulleau, Philippe, additional, Staiti, Giuseppe, additional, Bordes, Maryline, additional, Nouette Gaulain, Karine, additional, Hamonic, Yann, additional, Semjen, François, additional, Jacqmarcq, Olivier, additional, Lejus-Bourdeau, Caroline, additional, Magne, Cécile, additional, Petry, Léa, additional, Ros, Lilica, additional, Zang, Aurélien, additional, Bennis, Mehdi, additional, Coustets, Bernard, additional, Fesseau, Rose, additional, Constant, Isabelle, additional, Khalil, Eliane, additional, Sabourdin, Nada, additional, Audren, Noemie, additional, Descarpentries, Thomas, additional, Fabre, Fanny, additional, Legrand, Aurélien, additional, Druot, Emilie, additional, Orliaguet, Gilles, additional, Sabau, Lucie, additional, Uhrig, Lynn, additional, de la Brière, François, additional, Jonckheer, Karin, additional, Mission, Jean-Paul, additional, Scordo, Lucia, additional, Couchepin, Caroline, additional, Dadure, Christophe, additional, De la Arena, Pablo, additional, Hertz, Laurent, additional, Pirat, Philippe, additional, Sola, Chrystelle, additional, Bellon, Myriam, additional, Dahmani, Souhayl, additional, Julien-Marsollier, Florence, additional, Michelet, Daphne, additional, Depret-Donatien, Veronique, additional, Lesage, Anne, additional, Laschat, Michael, additional, Wappler, Frank, additional, Becke, Karin, additional, Brunner, Lena, additional, Oppenrieder, Karin, additional, Badelt, Gregor, additional, Hochmuth, Karin, additional, Koller, Bernhard, additional, Reil, Anita, additional, Richter, Sebastian, additional, Fischer, Thomas, additional, Diers, Anja, additional, Schorer, Clemens, additional, Weyland, Andreas, additional, Cohausz, Ruth, additional, Kretz, Franz-Josef, additional, Löffler, Michaela, additional, Wilbs, Markus, additional, Hoehne, Claudia, additional, Ulrici, Johanna, additional, Goeters, Christiane, additional, Flinspach, Armin, additional, Klages, Matthias, additional, Lindau, Simone, additional, Messroghli, Leila, additional, Zacharowski, Kai, additional, Eisner, Christoph, additional, Mueller, Thomas, additional, Richter, Daniel, additional, Schäfer, Melanie, additional, Weigand, Markus, additional, Weiterer, Sebastian, additional, Ochsenreiter, Miriam, additional, Schöler, Michael, additional, Terboven, Tom, additional, Eggemann, Isabel, additional, Haussmann, Sascha, additional, Leister, Nicolas, additional, Menzel, Christoph, additional, Trieschmann, Uwe, additional, Yücetepe, Sirin, additional, Keilig, Susanna, additional, Kranke, Peter, additional, Jelting, Yvonne, additional, Baehner, Torsten, additional, Ellerkmann, Richard, additional, Ghamari, Shahab, additional, Neumann, Claudia, additional, Söhle, Martin, additional, Chloropoulou, Pelagia, additional, Ntritsou, Vagia, additional, Papagiannopoulou, Pinelopi, additional, Garini, Eleana, additional, Karafotia, Afroditi, additional, Mammi, Panagoula, additional, Bali, Evangelia, additional, Iordanidou, Despoina, additional, Malisiova, Anna, additional, Polyzoi, Artemis, additional, Tsiotou, Adelais, additional, Sapi, Erzsebet, additional, Székely, Edgar, additional, Kosik, Nandor, additional, Maráczi, Veronika, additional, Schnur, Janos, additional, Csillag, Judit, additional, Gál, János, additional, Göbl, Gergely, additional, Hauser, Balázs, additional, Petróczy, András, additional, Tövisházi, Gyula, additional, Blain, Stuart, additional, Gallagher, Sarah, additional, Harte, Sinead, additional, Jackson, Mandy, additional, Meehan, Emma, additional, Nawoor, Zeenat, additional, O’Hare, Brendan, additional, Ross, Mark, additional, Lerro, Daniela, additional, Astuto, Marinella, additional, Grasso, Chiara, additional, Scalisi, Rita, additional, Frasacco, Giulia, additional, Lenares, Elena, additional, Leone, Roberto, additional, Grazzini, Maurizia, additional, Minardi, Carmelo, additional, Zadra, Nicola, additional, Cinnella, Gilda, additional, Cotoia, Antonella, additional, Galante, Dario, additional, De Lorenzo, Brita, additional, Kuppers, Beate, additional, Bottazzi, Giulia, additional, Caramelli, Fabio, additional, Mondardini, Maria Cristina, additional, Rossetti, Emanuele, additional, Picardo, Sergio, additional, Vittori, Alessandro, additional, Camporesi, Anna, additional, Wolfler, Andrea, additional, Calderini, Edoardo, additional, Colantonio, Laura Brigitta, additional, Finamore, Simona Anna, additional, Porro, Giuliana Anna, additional, Bonfiglio, Rachele, additional, Disma, Nicola, additional, Kotzeva, Svetlana, additional, Mameli, Leila, additional, Mattioli, Girolamo, additional, Micalizzi, Camilla, additional, Montaguti, Alessia, additional, Pistorio, Angela, additional, Zanaboni, Clelia, additional, Guddo, Anna, additional, Neba, Gerald Rogan, additional, Favarato, Moreno, additional, Locatelli, Bruno Guido, additional, Maffioletti, Micol, additional, Sonzogni, Valter, additional, Garra, Rossella, additional, Sammartino, Maria, additional, Sbaraglia, Fabio, additional, Cortegiani, Andrea, additional, Moscarelli, Alessandra, additional, Attanasi, Elena, additional, Tesoro, Simonetta, additional, Agapiti, Cristina, additional, Pinzoni, Francesca, additional, Vezzoli, Cesare, additional, Bilotta, Federico, additional, Barzdina, Arta, additional, Straume, Zane, additional, Zundane, Anda, additional, Lukosiene, Laura, additional, Maraulaite, Irena, additional, Razlevice, Ilona, additional, Schmitz, Bernd, additional, Mifsud, Stephanie, additional, Aehling, Carolin, additional, Allison, Celia, additional, De Boer, Rients, additional, Emal, Dina, additional, Stevens, Markus, additional, Buitenhuis, Marielle, additional, de Graaff, Jurgen, additional, De Liefde, Inge, additional, Machotta, Andreas, additional, Scoones, Gail, additional, Staals, Lonneke, additional, Tomas, Jeremy, additional, Van der Knijff-van Dortmont, Anouk, additional, Veldhuizen, Marianne, additional, Alders, David, additional, Buhre, Wolfgang, additional, Schafrat, Eva, additional, Schreiber, Jan, additional, Vermeulen, Petronella Mari, additional, Hendriks, Mark, additional, Lako, Sandra, additional, Voet-Lindner, Marieke, additional, Pieters, Barbe, additional, Scheffer, Gert-Jan, additional, Tielens, Luc, additional, Absalom, Anthony R., additional, Bergsma, Margot, additional, De Ruiter, Joke, additional, Meier, Sascha, additional, Volkers, Martin, additional, Zweers, Tjerk, additional, Beukers, Anne M., additional, Boer, Christa, additional, Dertinger, Jurgen, additional, Numan, Sandra, additional, Van Zaane, Bas, additional, Boerke, Wenche B., additional, Ekiz, Nil, additional, Stensrud, Kristoffer, additional, Drage, Inger Marie, additional, Isern, Erik Ramon, additional, Bartkowska-Sniatkowska, Alicja, additional, Grzeskowiak, Malgorzata, additional, Juzwa-Sobieraj, Magdalena, additional, Rosada-Kurasińska, Jowita, additional, Baranowski, Artur, additional, Jakubowska, Karina, additional, Lewandowska, Dorota, additional, Mierzewska-Schmidt, Magdalena, additional, Sawicki, Piotr, additional, Urban-Lechowicz, Magdalena, additional, Przemyslaw, Pomianek, additional, Zielinska, Marzena, additional, Leal, Teresa, additional, Soares, Maria, additional, Pina, Pedro, additional, Pinho, Sílvia, additional, Patuleia, Maria Domingas, additional, Esteves, Catarina Cruz, additional, Salgado, Helena, additional, Santos, Maria João, additional, Badeti, Rodica, additional, Cindea, Iulia, additional, Oana, Loredana, additional, Gurita, Adriana, additional, Ilie, Luminita, additional, Mocioiu, Gabriel, additional, Tabacaru, Radu, additional, Trante, Irina, additional, Munteanu, Valentin, additional, Morariu, Mihai, additional, Nyíri, Emese, additional, Budic, Ivana, additional, Marjanovic, Vesna, additional, Drašković, Biljana, additional, Pandurov, Marina, additional, Ilic, Jordanka, additional, Mandras, Ana, additional, Rados, Zdenka, additional, Stankovic, Nikola, additional, Suica, Maja, additional, Vasiljevic, Sladjana, additional, Knezevic, Mirjana, additional, Milojevic, Irina, additional, Petrov, Ivana, additional, Puric Racic, Selena, additional, Simic, Dusica, additional, Simic, Irena, additional, Stevic, Marija, additional, Vulicevic, Irena, additional, Cabanová, Barbora, additional, Hanula, Miloslav, additional, Berger, Jelena, additional, Janjatovic, Darja, additional, Pirtovšek Štupnik, Špela, additional, Méndez, Dolores, additional, Pino, Gema, additional, Rubio, Paloma, additional, Izquierdo, Alberto, additional, López, Silvia, additional, González Serrano, Cristina, additional, Cebrián, Jesús, additional, Peleteiro, Ana, additional, Del Rey de Diego, Pilar, additional, Martínez García, Ernesto, additional, Tormo de las Heras, Carolina, additional, Troncoso Montero, Pablo, additional, Arbona, Celia, additional, Artés, David, additional, Chamizo, Alicia, additional, Serrano, Silvia, additional, Suarez Comas, Montserrat, additional, Escribá, Francisco, additional, Auli, Cristina, additional, Pérez Pardo, Osvaldo, additional, Sierra Biddle, Natalia, additional, Suárez Castaño, Ceferina, additional, Villalobos Rico, María Isabel, additional, Manrique Muñoz, Susana, additional, García Martínez, Irene, additional, Montferrer Estruch, Nuria, additional, Vilardell Ortíz, Elena, additional, Poves-Álvarez, Rodrigo, additional, Kohn, Ivan, additional, Lindestam, Ulf, additional, Reinhard, Jarl, additional, Castellheim, Albert, additional, Sandström, Kerstin, additional, Bengt, Sporre, additional, Dörenberg, Rainer, additional, Frykholm, Peter, additional, Garcia, Maria, additional, Kvarnström, Ann, additional, Pontén, Emma, additional, Bruelisauer, Thomas, additional, Erdoes, Gabor, additional, Kaiser, Heiko, additional, Marchon, Mathias, additional, Seiler, Stefan, additional, Bögli, Yann, additional, Dolci, Mirko, additional, Marcucci, Carine, additional, Pichon, Isabelle, additional, Vutskits, Laszlo, additional, Casutt, Mattias, additional, Hölzle, Martin, additional, Hurni, Thomas, additional, Jöhr, Martin, additional, Malär, Anna-Ursina, additional, Mauch, Jacqueline, additional, Erb, Thomas, additional, Oeinck, Karin, additional, Akin, Mine, additional, Keskin, Gulsen, additional, Senayli, Yesim, additional, Kaya, Guner, additional, Kendigelen, Pinar, additional, Tutuncu, Ayse Çiğdem, additional, Hatipoğlu, Zehra, additional, Özcengiz, Dilek, additional, Erdost, Hale Aksu, additional, Öçmen, Elvan, additional, Olguner, Çimen, additional, Ayanoglu, Hilmi, additional, Dincer, Pelin Corman, additional, Umuroglu, Tumay, additional, Azizoglu, Mustafa, additional, Birbiçer, Handan, additional, Doruk, Nurcan, additional, Sagun, Aslı, additional, Baris, Sibel, additional, Dmytriiev, Dmytro, additional, Kuchi, Sridevi, additional, Masip, Nuria, additional, Brooks, Peter, additional, Hare, Alison, additional, Ahmad, Nargis, additional, Casey, Michelle, additional, De Silva, Sam, additional, Dobby, Nadine, additional, Krishnan, Prakash, additional, Sogbodjor, L. Amaki, additional, Walker, Ellie, additional, Walker, Suellen, additional, King, Stephanie, additional, Nicholson, Katy, additional, Quinney, Michelle, additional, Stevens, Paul, additional, Blevin, Andrew, additional, Giombini, Mariangela, additional, Goonasekera, Chulananda, additional, Adil, Sadia, additional, Bew, Stephanie, additional, Bodlani, Carol, additional, Gilpin, Dan, additional, Jinks, Stephanie, additional, Malarkkan, Nalini, additional, Miskovic, Alice, additional, Pad, Rebecca, additional, Wolfe Barry, Juliet, additional, Abbott, Joy, additional, Armstrong, James, additional, Cooper, Natalie, additional, Crate, Lindsay, additional, Emery, John, additional, James, Kathryn, additional, King, Hannah, additional, Martin, Paul, additional, Scalia Catenacci, Stefano, additional, Bomont, Rob, additional, Smith, Paul, additional, Mele, Sara, additional, Verzelloni, Alessandra, additional, Dix, Philippa, additional, Bell, Graham, additional, Gordeva, Elena, additional, McKee, Lesley, additional, Ngan, Esther, additional, Scheffczik, Jutta, additional, Tan, Li-En, additional, Worrall, Mark, additional, Cassar, Carmel, additional, Goddard, Kevin, additional, Barlow, Victoria, additional, Oshan, Vimmi, additional, Shah, Khairi, additional, Bell, Sarah, additional, Daniels, Lisa, additional, Gandhi, Monica, additional, Pachter, David, additional, Perry, Chris, additional, Robertson, Andrew, additional, Scott, Carmen, additional, Waring, Lynne, additional, Barnes, David, additional, Childs, Sophie, additional, Norman, Joanne, additional, Sunderland, Robin, additional, Julia, Dowell, additional, Prisca, Feijten, additional, Pierre, Harlet, additional, Sarah, Herbineaux, additional, Brigitte, Leva, additional, Benoît, Plichon, additional, and Katalin, Virág, additional

Published
2021
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17. HydroSOS – the Hydrological Status and Outlook System towards providing information for better water management

Author

Jenkins, Alan, Dixon, Harry, Barlow, Victoria, Smith, Katie, Cullmann, Johannes, Berod, Dominique, Kim, Hwirin, Schwab, Michael, Silva Vara, Luis Roberto, Jenkins, Alan, Dixon, Harry, Barlow, Victoria, Smith, Katie, Cullmann, Johannes, Berod, Dominique, Kim, Hwirin, Schwab, Michael, and Silva Vara, Luis Roberto

Abstract

The main objective of HydroSOS is to develop a global framework for the production and sharing of water-related information products to inform water resources management by bringing National Meteorological and Hydrological Services together.

Published
2020

18. The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway

Author

De Cesare, Virginia, Johnson, Clare, Barlow, Victoria, Hastie, James, Knebel, Axel, and Trost, Matthias

Subjects
MALDI-TOF, E2 enzyme, high-throughput assay, HOIP, Ubiquitin, Ubiquitin-Protein Ligases, Ubiquitination, ITCH, Article, High-Throughput Screening Assays, Small Molecule Libraries, MDM2, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Drug Discovery, Ubiquitin-Conjugating Enzymes, Humans, Enzyme Inhibitors, E3 ligase, mass spectrometry
Abstract

Summary Due to their role in many diseases, enzymes of the ubiquitin system have recently become interesting drug targets. Despite efforts, primary screenings of compound libraries targeting E2 enzymes and E3 ligases have been strongly limited by the lack of robust and fast high-throughput assays. Here we report a label-free high-throughput screening assay for ubiquitin E2 conjugating enzymes and E3 ligases based on MALDI-TOF mass spectrometry. The MALDI-TOF E2/E3 assay allows testing E2 enzymes and E3 ligases for their ubiquitin transfer activity, identifying E2/E3 active pairs, inhibitor potency and specificity and screening compound libraries in vitro without chemical or fluorescent probes. We demonstrate that the MALDI-TOF E2/E3 assay is a universal tool for drug discovery screening in the ubiquitin pathway as it is suitable for working with all E3 ligase families and requires a reduced amount of reagents, compared with standard biochemical assays., Graphical Abstract, Highlights • We have developed a high-throughput MALDI-TOF assay for E2/E3 enzymes • It allows screening compound libraries without chemical or fluorescent probes • We tested the screen on three disease-relevant E3 ligases: MDM2, ITCH, and HOIP • We performed a proof-of-concept high-throughput screen against 1,430 compounds, Due to their role in many diseases, there is a need to identify drug candidates for enzymes of the ubiquitin system in robust and high-throughput assays. Here we report as label-free high-throughput screening assay for ubiquitin E2 conjugating enzymes and E3 ligases based on MALDI-TOF mass spectrometry.

Published
2017

19. Corrigendum to ‘Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study’ (Br J Anaesth 2021; 126: 1173–81)

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Kerovec Sorić, Ivana, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Nouette Gaulain, Karine, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cécile, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Brière, François, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Puric Racic, Selena, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Pirtovšek Štupnik, Špela, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, González Serrano, Cristina, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, Martínez García, Ernesto, Tormo de las Heras, Carolina, Troncoso Montero, Pablo, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Suarez Comas, Montserrat, Escribá, Francisco, Auli, Cristina, Pérez Pardo, Osvaldo, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Villalobos Rico, María Isabel, Manrique Muñoz, Susana, García Martínez, Irene, Montferrer Estruch, Nuria, Vilardell Ortíz, Elena, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Wolfe Barry, Juliet, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Scalia Catenacci, Stefano, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Virag, Katalin, and Engelhardt, Thomas

Published
2021
Full Text
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20. Identification of bacterial posttranslational modifications that regulate antimicrobial resistance

Author

Barlow, Victoria and Barlow, Victoria

Abstract

Rapidly spreading antimicrobial resistance is one of the greatest threats to human health of our time. There exists many mechanisms by which bacteria evade destruction by antibiotics and various research is being conducted globally in an attempt to combat this alarming situation. A so far under-researched area is the hypothesised role of protein post-translational modifications in the regulation of antimicrobial resistance responses. This thesis identifies two proteins involved in antimicrobial resistance and known to undergo post-translational modification, then uses genetic code expansion and unnatural amino acid incorporation to characterise the effect of these modifications on protein function. The first protein is AdeT1, a component of a multi-drug efflux pump from the multidrug resistant pathogen Acinetobacter baumannii, which undergoes lysine propionylation at Lys280 in vivo. Here, such propionylation is shown to modulate function of the efflux pump in living cells, with the propionylated protein complex demonstrating increased ethidium bromide efflux. Further, cells producing propionylated AdeT1 required a 6-fold higher concentration of erythromycin to inhibit their growth compared to cells producing unmodified AdeT1. The second protein investigated is the DNA-binding protein HU from Escherichia coli, which undergoes acetylation at five lysine residues in vivo. The protein was characterised in DNA-binding assays in vitro, which revealed that protein acetylated at Lys86 has significantly lower affinity for DNA compared to its wildtype counterpart. The consequences of such altered binding on bacterial gene expression and antimicrobial resistance are contemplated. Together, the results presented here are in agreement with the known roles of post-translational modifications in modulating protein function and provide evidence toward a novel analysis of posttranslational modifications as regulatory components in antimicrobial resistance responses

21. Identification of bacterial posttranslational modifications that regulate antimicrobial resistance

Author

Barlow, Victoria and Barlow, Victoria

Abstract

Rapidly spreading antimicrobial resistance is one of the greatest threats to human health of our time. There exists many mechanisms by which bacteria evade destruction by antibiotics and various research is being conducted globally in an attempt to combat this alarming situation. A so far under-researched area is the hypothesised role of protein post-translational modifications in the regulation of antimicrobial resistance responses. This thesis identifies two proteins involved in antimicrobial resistance and known to undergo post-translational modification, then uses genetic code expansion and unnatural amino acid incorporation to characterise the effect of these modifications on protein function. The first protein is AdeT1, a component of a multi-drug efflux pump from the multidrug resistant pathogen Acinetobacter baumannii, which undergoes lysine propionylation at Lys280 in vivo. Here, such propionylation is shown to modulate function of the efflux pump in living cells, with the propionylated protein complex demonstrating increased ethidium bromide efflux. Further, cells producing propionylated AdeT1 required a 6-fold higher concentration of erythromycin to inhibit their growth compared to cells producing unmodified AdeT1. The second protein investigated is the DNA-binding protein HU from Escherichia coli, which undergoes acetylation at five lysine residues in vivo. The protein was characterised in DNA-binding assays in vitro, which revealed that protein acetylated at Lys86 has significantly lower affinity for DNA compared to its wildtype counterpart. The consequences of such altered binding on bacterial gene expression and antimicrobial resistance are contemplated. Together, the results presented here are in agreement with the known roles of post-translational modifications in modulating protein function and provide evidence toward a novel analysis of posttranslational modifications as regulatory components in antimicrobial resistance responses

22. MRES Solar Trailer Lights Up the Night.

Author

Barlow, Victoria

Subjects
TRAILERS, RENEWABLE energy transition (Government policy)
Abstract

The GLOW winter wonderland experience featured a COVID-safe one-mile drive thru at the MN State Fairgrounds, employing more than a million LED holiday lights, a dozen stunning stops, a 100-foot glistening Christmas tree, icicles, art installations and a Minnesota State Fair foods finale. The Minnesota Renewable Energy Society Solar Trailer "lit up the night" with renewable energy at the inaugural GLOW Holiday Festival at the Minnesota State Fairgrounds November 19th through January 3rd. [Extracted from the article]

Published
2021

23. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE)

Author

Nicola Disma, Katalin Virag, Thomas Riva, Jost Kaufmann, Thomas Engelhardt, Walid Habre, Christian Breschan, Rudolf Likar, Manuela Platzer, Isole Edelman, Johanes Eger, Stefan Heschl, Brigitte Messerer, Maria Vittinghof, Ruth Kroess, Martina Stichlberger, David Kahn, Thierry Pirotte, Caroline Pregardien, Francis Veyckemans, France Stevens, Johan Berghmans, Annemie Bauters, Luc De Baerdemaeker, Stefan De Hert, Koen Lapage, Aliaksandra Parashchanka, Jurgen Van Limmen, Piet Wyffels, Julie Lauweryns, Nadia Najafi, Joris Vundelinckx, Diana Butković, Ivana Kerovec Sorić, Sandra Kralik, Ana Markić, Josip Azman, Josko Markic, Daniela Pupacic, Michal Frelich, Petr Reimer, René Urbanec, Petra Cajková, Vladimír Mixa, Yvona Sedláčková, Lenka Knoppová, Alena Zlámalová (neé Květoňová), Martin Vavřina, Jiří Žurek, Tom Hansen, Arash Afshari, Anders Bastholm Bille, Marguerite Ellekvist, Mari-Liis Ilmoja, Reet Moor, Reet Kikas, Merle Väli, Kariantti Kallio, Elisa Reponen, Pertti Suominen, Sami Suvanto, Raisa Vähätalo, Hannu Kokki, Merja Kokki, Jarkko Harju, Miia Kokkonen, Jenni Vieri, Tuula Manner, Catherine Amory, Hugues Ludot, Dina Bert, Juliette Godart, Anne Laffargue, Hervé Dupont, Benjamin Urbina, Catherine Baujard, Philippe Roulleau, Giuseppe Staiti, Maryline Bordes, Karine Nouette Gaulain, Yann Hamonic, François Semjen, Olivier Jacqmarcq, Caroline Lejus-Bourdeau, Cécile Magne, Léa Petry, Lilica Ros, Aurélien Zang, Mehdi Bennis, Bernard Coustets, Rose Fesseau, Isabelle Constant, Eliane Khalil, Nada Sabourdin, Noemie Audren, Thomas Descarpentries, Fanny Fabre, Aurélien Legrand, Emilie Druot, Gilles Orliaguet, Lucie Sabau, Lynn Uhrig, François de la Brière, Karin Jonckheer, Jean-Paul Mission, Lucia Scordo, Caroline Couchepin, Christophe Dadure, Pablo De la Arena, Laurent Hertz, Philippe Pirat, Chrystelle Sola, Myriam Bellon, Souhayl Dahmani, Florence Julien-Marsollier, Daphne Michelet, Veronique Depret-Donatien, Anne Lesage, Michael Laschat, Frank Wappler, Karin Becke, Lena Brunner, Karin Oppenrieder, Gregor Badelt, Karin Hochmuth, Bernhard Koller, Anita Reil, Sebastian Richter, Thomas Fischer, Anja Diers, Clemens Schorer, Andreas Weyland, Ruth Cohausz, Franz-Josef Kretz, Michaela Löffler, Markus Wilbs, Claudia Hoehne, Johanna Ulrici, Christiane Goeters, Armin Flinspach, Matthias Klages, Simone Lindau, Leila Messroghli, Kai Zacharowski, Christoph Eisner, Thomas Mueller, Daniel Richter, Melanie Schäfer, Markus Weigand, Sebastian Weiterer, Miriam Ochsenreiter, Michael Schöler, Tom Terboven, Isabel Eggemann, Sascha Haussmann, Nicolas Leister, Christoph Menzel, Uwe Trieschmann, Sirin Yücetepe, Susanna Keilig, Peter Kranke, Yvonne Jelting, Torsten Baehner, Richard Ellerkmann, Shahab Ghamari, Claudia Neumann, Martin Söhle, Pelagia Chloropoulou, Vagia Ntritsou, Pinelopi Papagiannopoulou, Eleana Garini, Afroditi Karafotia, Panagoula Mammi, Evangelia Bali, Despoina Iordanidou, Anna Malisiova, Artemis Polyzoi, Adelais Tsiotou, Erzsebet Sapi, Edgar Székely, Nandor Kosik, Veronika Maráczi, Janos Schnur, Judit Csillag, János Gál, Gergely Göbl, Balázs Hauser, András Petróczy, Gyula Tövisházi, Stuart Blain, Sarah Gallagher, Sinead Harte, Mandy Jackson, Emma Meehan, Zeenat Nawoor, Brendan O’Hare, Mark Ross, Daniela Lerro, Marinella Astuto, Chiara Grasso, Rita Scalisi, Giulia Frasacco, Elena Lenares, Roberto Leone, Maurizia Grazzini, Carmelo Minardi, Nicola Zadra, Gilda Cinnella, Antonella Cotoia, Dario Galante, Brita De Lorenzo, Beate Kuppers, Giulia Bottazzi, Fabio Caramelli, Maria Cristina Mondardini, Emanuele Rossetti, Sergio Picardo, Alessandro Vittori, Anna Camporesi, Andrea Wolfler, Edoardo Calderini, Laura Brigitta Colantonio, Simona Anna Finamore, Giuliana Anna Porro, Rachele Bonfiglio, Svetlana Kotzeva, Leila Mameli, Girolamo Mattioli, Camilla Micalizzi, Alessia Montaguti, Angela Pistorio, Clelia Zanaboni, Anna Guddo, Gerald Rogan Neba, Moreno Favarato, Bruno Guido Locatelli, Micol Maffioletti, Valter Sonzogni, Rossella Garra, Maria Sammartino, Fabio Sbaraglia, Andrea Cortegiani, Alessandra Moscarelli, Elena Attanasi, Simonetta Tesoro, Cristina Agapiti, Francesca Pinzoni, Cesare Vezzoli, Federico Bilotta, Arta Barzdina, Zane Straume, Anda Zundane, Laura Lukosiene, Irena Maraulaite, Ilona Razlevice, Bernd Schmitz, Stephanie Mifsud, Carolin Aehling, Celia Allison, Rients De Boer, Dina Emal, Markus Stevens, Marielle Buitenhuis, Jurgen de Graaff, Inge De Liefde, Andreas Machotta, Gail Scoones, Lonneke Staals, Jeremy Tomas, Anouk Van der Knijff-van Dortmont, Marianne Veldhuizen, David Alders, Wolfgang Buhre, Eva Schafrat, Jan Schreiber, Petronella Mari Vermeulen, Mark Hendriks, Sandra Lako, Marieke Voet-Lindner, Barbe Pieters, Gert-Jan Scheffer, Luc Tielens, Anthony R. Absalom, Margot Bergsma, Joke De Ruiter, Sascha Meier, Martin Volkers, Tjerk Zweers, Anne M. Beukers, Christa Boer, Jurgen Dertinger, Sandra Numan, Bas Van Zaane, Wenche B. Boerke, Nil Ekiz, Kristoffer Stensrud, Inger Marie Drage, Erik Ramon Isern, Alicja Bartkowska-Sniatkowska, Malgorzata Grzeskowiak, Magdalena Juzwa-Sobieraj, Jowita Rosada-Kurasińska, Artur Baranowski, Karina Jakubowska, Dorota Lewandowska, Magdalena Mierzewska-Schmidt, Piotr Sawicki, Magdalena Urban-Lechowicz, Pomianek Przemyslaw, Marzena Zielinska, Teresa Leal, Maria Soares, Pedro Pina, Sílvia Pinho, Maria Domingas Patuleia, Catarina Cruz Esteves, Helena Salgado, Maria João Santos, Rodica Badeti, Iulia Cindea, Loredana Oana, Adriana Gurita, Luminita Ilie, Gabriel Mocioiu, Radu Tabacaru, Irina Trante, Valentin Munteanu, Mihai Morariu, Emese Nyíri, Ivana Budic, Vesna Marjanovic, Biljana Drašković, Marina Pandurov, Jordanka Ilic, Ana Mandras, Zdenka Rados, Nikola Stankovic, Maja Suica, Sladjana Vasiljevic, Mirjana Knezevic, Irina Milojevic, Ivana Petrov, Selena Puric Racic, Dusica Simic, Irena Simic, Marija Stevic, Irena Vulicevic, Barbora Cabanová, Miloslav Hanula, Jelena Berger, Darja Janjatovic, Špela Pirtovšek Štupnik, Dolores Méndez, Gema Pino, Paloma Rubio, Alberto Izquierdo, Silvia López, Cristina González Serrano, Jesús Cebrián, Ana Peleteiro, Pilar Del Rey de Diego, Ernesto Martínez García, Carolina Tormo de las Heras, Pablo Troncoso Montero, Celia Arbona, David Artés, Alicia Chamizo, Silvia Serrano, Montserrat Suarez Comas, Francisco Escribá, Cristina Auli, Osvaldo Pérez Pardo, Natalia Sierra Biddle, Ceferina Suárez Castaño, María Isabel Villalobos Rico, Susana Manrique Muñoz, Irene García Martínez, Nuria Montferrer Estruch, Elena Vilardell Ortíz, Rodrigo Poves-Álvarez, Ivan Kohn, Ulf Lindestam, Jarl Reinhard, Albert Castellheim, Kerstin Sandström, Sporre Bengt, Rainer Dörenberg, Peter Frykholm, Maria Garcia, Ann Kvarnström, Emma Pontén, Thomas Bruelisauer, Gabor Erdoes, Heiko Kaiser, Mathias Marchon, Stefan Seiler, Yann Bögli, Mirko Dolci, Carine Marcucci, Isabelle Pichon, Laszlo Vutskits, Mattias Casutt, Martin Hölzle, Thomas Hurni, Martin Jöhr, Anna-Ursina Malär, Jacqueline Mauch, Thomas Erb, Karin Oeinck, Mine Akin, Gulsen Keskin, Yesim Senayli, Guner Kaya, Pinar Kendigelen, Ayse Çiğdem Tutuncu, Zehra Hatipoğlu, Dilek Özcengiz, Hale Aksu Erdost, Elvan Öçmen, Çimen Olguner, Hilmi Ayanoglu, Pelin Corman Dincer, Tumay Umuroglu, Mustafa Azizoglu, Handan Birbiçer, Nurcan Doruk, Aslı Sagun, Sibel Baris, Dmytro Dmytriiev, Sridevi Kuchi, Nuria Masip, Peter Brooks, Alison Hare, Nargis Ahmad, Michelle Casey, Sam De Silva, Nadine Dobby, Prakash Krishnan, L. Amaki Sogbodjor, Ellie Walker, Suellen Walker, Stephanie King, Katy Nicholson, Michelle Quinney, Paul Stevens, Andrew Blevin, Mariangela Giombini, Chulananda Goonasekera, Sadia Adil, Stephanie Bew, Carol Bodlani, Dan Gilpin, Stephanie Jinks, Nalini Malarkkan, Alice Miskovic, Rebecca Pad, Juliet Wolfe Barry, Joy Abbott, James Armstrong, Natalie Cooper, Lindsay Crate, John Emery, Kathryn James, Hannah King, Paul Martin, Stefano Scalia Catenacci, Rob Bomont, Paul Smith, Sara Mele, Alessandra Verzelloni, Philippa Dix, Graham Bell, Elena Gordeva, Lesley McKee, Esther Ngan, Jutta Scheffczik, Li-En Tan, Mark Worrall, Carmel Cassar, Kevin Goddard, Victoria Barlow, Vimmi Oshan, Khairi Shah, Sarah Bell, Lisa Daniels, Monica Gandhi, David Pachter, Chris Perry, Andrew Robertson, Carmen Scott, Lynne Waring, David Barnes, Sophie Childs, Joanne Norman, Robin Sunderland, Dowell Julia, Feijten Prisca, Harlet Pierre, Herbineaux Sarah, Leva Brigitte, Plichon Benoît, Virág Katalin, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Anesthesiology, HUS Children and Adolescents, Children's Hospital, Clinicum, Anestesiologian yksikkö, Disma, Nicola, Virag, Katalin, Riva, Thoma, Kaufmann, Jost, Engelhardt, Thoma, Habre, Walid, Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johane, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Franci, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Jori, Butković, Diana, Kerovec Sorić, Ivana, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Lii, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugue, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Nouette Gaulain, Karine, Hamonic, Yann, Semjen, Françoi, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cécile, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thoma, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gille, Sabau, Lucie, Uhrig, Lynn, de la Brière, Françoi, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thoma, Diers, Anja, Schorer, Clemen, Weyland, Andrea, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Marku, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthia, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thoma, Richter, Daniel, Schäfer, Melanie, Weigand, Marku, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicola, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemi, Tsiotou, Adelai, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Jano, Csillag, Judit, Gál, Jáno, Göbl, Gergely, Hauser, Baláz, Petróczy, Andrá, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rient, Emal, Dina, Stevens, Marku, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andrea, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Ba, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Dominga, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Puric Racic, Selena, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Pirtovšek Štupnik, Špela, Méndez, Dolore, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, González Serrano, Cristina, Cebrián, Jesú, Peleteiro, Ana, Del Rey de Diego, Pilar, Martínez García, Ernesto, Tormo de las Heras, Carolina, Troncoso Montero, Pablo, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Suarez Comas, Montserrat, Escribá, Francisco, Auli, Cristina, Pérez Pardo, Osvaldo, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Villalobos Rico, María Isabel, Manrique Muñoz, Susana, García Martínez, Irene, Montferrer Estruch, Nuria, Vilardell Ortíz, Elena, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thoma, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathia, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattia, Hölzle, Martin, Hurni, Thoma, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thoma, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargi, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Wolfe Barry, Juliet, Abbott, Joy, Armstrong, Jame, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Scalia Catenacci, Stefano, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chri, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, IOO, ACS - Microcirculation, APH - Quality of Care, and ANS - Neuroinfection & -inflammation

Subjects
Male, Time Factors, paediatric, medicine.medical_treatment, morbidity, Severity of Illness Index, 0302 clinical medicine, 030202 anesthesiology, Risk Factors, Clinical endpoint, Anesthesia, Prospective Studies, 610 Medicine & health, Hypoxia, Medical Audit, medicine.diagnostic_test, ddc:617, infants, Incidence (epidemiology), Incidence, Age Factors, anaesthesia, respiratory system, Europe, Treatment Outcome, Cohort, Female, medicine.symptom, Bradycardia, Laryngoscopy, Anesthesia/adverse effects/mortality, Risk Assessment, Europe/epidemiology, 03 medical and health sciences, Laryngoscopy/adverse effects/mortality, Hypoxia/diagnosis/epidemiology/mortality, medicine, Intubation, Intratracheal, Humans, difficult intubation, business.industry, Tracheal intubation, Infant, Newborn, Infant, Perioperative, Newborn, 3126 Surgery, anesthesiology, intensive care, radiology, mortality, neonates, Clinical trial, Intratracheal, Anesthesiology and Pain Medicine, airway, Intubation, Intratracheal/adverse effects/mortality, neonate, Intubation, business, airways
Abstract

Background: Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences. Methods: We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children audiT of Anaesthesia pRactice IN Europe [NECTARINE]) in neonates and small infants with difficult tracheal intubation. The primary endpoint was the incidence of difficult intubation and the related complications. The secondary endpoints were the risk factors for severe hypoxaemia attributed to difficult airway management, and 30 and 90 day outcomes. Results: Tracheal intubation was planned in 4683 procedures. Difficult tracheal intubation, defined as two failed attempts of direct laryngoscopy, occurred in 266 children (271 procedures) with an incidence (95% confidence interval [CI]) of 5.8% (95% CI, 5.1e6.5). Bradycardia occurred in 8% of the cases with difficult intubation, whereas a significant decrease in oxygen saturation (SpO2

Published
2021

24. Morbidity and mortality after anaesthesia in early life:results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Author

Nicola Disma, Francis Veyckemans, Katalin Virag, Tom G. Hansen, Karin Becke, Pierre Harlet, Laszlo Vutskits, Suellen M. Walker, Jurgen C. de Graaff, Marzena Zielinska, Dusica Simic, Thomas Engelhardt, Walid Habre, Christian Breschan, Rudolf Likar, Manuela Platzer, Isole Edelman, Johanes Eger, Stefan Heschl, Brigitte Messerer, Maria Vittinghof, Ruth Kroess, Martina Stichlberger, David Kahn, Thierry Pirotte, Caroline Pregardien, France Stevens, Johan Berghmans, Annemie Bauters, Luc De Baerdemaeker, Stefan De Hert, Koen Lapage, Aliaksandra Parashchanka, Jurgen Van Limmen, Piet Wyffels, Julie Lauweryns, Nadia Najafi, Joris Vundelinckx, Diana Butković, Ivana Kerovec Sorić, Sandra Kralik, Ana Markić, Josip Azman, Josko Markic, Daniela Pupacic, Michal Frelich, Petr Reimer, Rene Urbanec, Petra Cajkova, Vladimir Mixa, Yvona Sedlačkova, Lenka Knoppova, Alena Zlamalova (nee Květoňova), Martin Vavřina, Jiři Žurek, Tom Hansen, Arash Afshari, Anders B. Bille, Marguerite Ellekvist, Mari-Liis Ilmoja, Reet Moor, Reet Kikas, Merle Vali, Kariantti Kallio, Elisa Reponen, Pertti Suominen, Sami Suvanto, Raisa Vahatalo, Hannu Kokki, Merja Kokki, Jarkko Harju, Miia Kokkonen, Jenni Vieri, Tuula Manner, Catherine Amory, Hugues Ludot, Dina Bert, Juliette Godart, Anne Laffargue, Herve Dupont, Benjamin Urbina, Catherine Baujard, Philippe Roulleau, Giuseppe Staiti, Maryline Bordes, Karine Nouette Gaulain, Yann Hamonic, Francois Semjen, Olivier Jacqmarcq, Caroline Lejus-Bourdeau, Cecile Magne, Lea Petry, Lilica Ros, Aurelien Zang, Mehdi Bennis, Bernard Coustets, Rose Fesseau, Isabelle Constant, Eliane Khalil, Nada Sabourdin, Noemie Audren, Thomas Descarpentries, Fanny Fabre, Aurelien Legrand, Emilie Druot, Gilles Orliaguet, Lucie Sabau, Lynn Uhrig, Francois de la Briere, Karin Jonckheer, Jean-Paul Mission, Lucia Scordo, Caroline Couchepin, Christophe Dadure, Pablo De la Arena, Laurent Hertz, Philippe Pirat, Chrystelle Sola, Myriam Bellon, Souhayl Dahmani, Florence Julien-Marsollier, Daphne Michelet, Veronique Depret-Donatien, Anne Lesage, Jost Kaufmann, Michael Laschat, Frank Wappler, Lena Brunner, Karin Oppenrieder, Gregor Badelt, Karin Hochmuth, Bernhard Koller, Anita Reil, Sebastian Richter, Thomas Fischer, Anja Diers, Clemens Schorer, Andreas Weyland, Ruth Cohausz, Franz-Josef Kretz, Michaela Loffler, Markus Wilbs, Claudia Hoehne, Johanna Ulrici, Christiane Goeters, Armin Flinspach, Matthias Klages, Simone Lindau, Leila Messroghli, Kai Zacharowski, Christoph Eisner, Thomas Mueller, Daniel Richter, Melanie Schafer, Markus Weigand, Sebastian Weiterer, Miriam Ochsenreiter, Michael Scholer, Tom Terboven, Isabel Eggemann, Sascha Haussmann, Nicolas Leister, Christoph Menzel, Uwe Trieschmann, Sirin Yucetepe, Susanna Keilig, Peter Kranke, Yvonne Jelting, Torsten Baehner, Richard Ellerkmann, Shahab Ghamari, Claudia Neumann, Martin Sohle, Pelagia Chloropoulou, Vagia Ntritsou, Pinelopi Papagiannopoulou, Eleana Garini, Afroditi Karafotia, Panagoula Mammi, Evangelia Bali, Despoina Iordanidou, Anna Malisiova, Artemis Polyzoi, Adelais Tsiotou, Erzsebet Sapi, Edgar Szekely, Nandor Kosik, Veronika Maraczi, Janos Schnur, Judit Csillag, Janos Gal, Gergely Gobl, Balazs Hauser, Andras Petroczy, Gyula Tovishazi, Stuart Blain, Sarah Gallagher, Sinead Harte, Mandy Jackson, Emma Meehan, Zeenat Nawoor, Brendan O’Hare, Mark Ross, Daniela Lerro, Marinella Astuto, Chiara Grasso, Rita Scalisi, Giulia Frasacco, Elena Lenares, Roberto Leone, Maurizia Grazzini, Carmelo Minardi, Nicola Zadra, Gilda Cinnella, Antonella Cotoia, Dario Galante, Brita De Lorenzo, Beate Kuppers, Giulia Bottazzi, Fabio Caramelli, Maria C. Mondardini, Emanuele Rossetti, Sergio Picardo, Alessandro Vittori, Anna Camporesi, Andrea Wolfler, Edoardo Calderini, Laura B. Colantonio, Simona A. Finamore, Giuliana A. Porro, Rachele Bonfiglio, Svetlana Kotzeva, Leila Mameli, Girolamo Mattioli, Camilla Micalizzi, Alessia Montaguti, Angela Pistorio, Clelia Zanaboni, Anna Guddo, Gerald R. Neba, Moreno Favarato, Bruno G. Locatelli, Micol Maffioletti, Valter Sonzogni, Rossella Garra, Maria Sammartino, Fabio Sbaraglia, Andrea Cortegiani, Alessandra Moscarelli, Elena Attanasi, Simonetta Tesoro, Cristina Agapiti, Francesca Pinzoni, Cesare Vezzoli, Federico Bilotta, Arta Barzdina, Zane Straume, Anda Zundane, Laura Lukosiene, Irena Maraulaite, Ilona Razlevice, Bernd Schmitz, Stephanie Mifsud, Carolin Aehling, Celia Allison, Rients De Boer, Dina Emal, Markus Stevens, Marielle Buitenhuis, Jurgen de Graaff, Inge De Liefde, Andreas Machotta, Gail Scoones, Lonneke Staals, Jeremy Tomas, Anouk Van der, Knijff-van Dortmont, Marianne Veldhuizen, David Alders, Wolfgang Buhre, Eva Schafrat, Jan Schreiber, Petronella M. Vermeulen, Mark Hendriks, Sandra Lako, Marieke Voet-Lindner, Barbe Pieters, Gert-Jan Scheffer, Luc Tielens, Anthony R. Absalom, Margot Bergsma, Joke De Ruiter, Sascha Meier, Martin Volkers, Tjerk Zweers, Anne M. Beukers, Christa Boer, Jurgen Dertinger, Sandra Numan, Bas Van Zaane, Wenche B. Boerke, Nil Ekiz, Kristoffer Stensrud, Inger M. Drage, Erik R. Isern, Alicja Bartkowska-Sniatkowska, Malgorzata Grzeskowiak, Magdalena Juzwa-Sobieraj, Jowita Rosada-Kurasińska, Artur Baranowski, Karina Jakubowska, Dorota Lewandowska, Magdalena Mierzewska-Schmidt, Piotr Sawicki, Magdalena Urban-Lechowicz, Pomianek Przemyslaw, Teresa Leal, Maria Soares, Pedro Pina, Silvia Pinho, Maria Domingas Patuleia, Catarina C. Esteves, Helena Salgado, Maria J. Santos, Rodica Badeti, Iulia Cindea, Loredana Oana, Adriana Gurita, Luminita Ilie, Gabriel Mocioiu, Radu Tabacaru, Irina Trante, Valentin Munteanu, Mihai Morariu, Emese Nyiri, Ivana Budic, Vesna Marjanovic, Biljana Drašković, Marina Pandurov, Jordanka Ilic, Ana Mandras, Zdenka Rados, Nikola Stankovic, Maja Suica, Sladjana Vasiljevic, Mirjana Knezevic, Irina Milojevic, Ivana Petrov, Selena Puric Racic, Irena Simic, Marija Stevic, Irena Vulicevic, Barbora Cabanova, Miloslav Hanula, Jelena Berger, Darja Janjatovic, Špela P. Štupnik, Ivan Kohn, Ulf Lindestam, Jarl Reinhard, Albert Castellheim, Kerstin Sandstrom, Sporre Bengt, Rainer Dorenberg, Peter Frykholm, Maria Garcia, Ann Kvarnstrom, Emma Ponten, Thomas Bruelisauer, Gabor Erdoes, Heiko Kaiser, Mathias Marchon, Thomas Riva, Stefan Seiler, Yann Bogli, Mirko Dolci, Carine Marcucci, Isabelle Pichon, Mattias Casutt, Martin Holzle, Thomas Hurni, Martin Johr, null Anna-Ursina, null Malar, Jacqueline Mauch, Thomas Erb, Karin Oeinck, Mine Akin, Gulsen Keskin, Yesim Senayli, Guner Kaya, Pinar Kendigelen, Ayse C. Tutuncu, Zehra Hatipoğlu, Dilek Ozcengiz, Hale Aksu Erdost, Elvan Ocmen, Cimen Olguner, Hilmi Ayanoglu, Pelin C. Dincer, Tumay Umuroglu, Mustafa Azizoglu, Handan Birbicer, Nurcan Doruk, Aslı Sagun, Sibel Baris, Dmytro Dmytriiev, Sridevi Kuchi, Nuria Masip, Peter Brooks, Alison Hare, Nargis Ahmad, Michelle Casey, Sam De Silva, Nadine Dobby, Prakash Krishnan, L. Amaki Sogbodjor, Ellie Walker, Suellen Walker, Stephanie King, Katy Nicholson, Michelle Quinney, Paul Stevens, Andrew Blevin, Mariangela Giombini, Chulananda Goonasekera, Sadia Adil, Stephanie Bew, Carol Bodlani, Dan Gilpin, Stephanie Jinks, Nalini Malarkkan, Alice Miskovic, Rebecca Pad, Juliet W. Barry, Joy Abbott, James Armstrong, Natalie Cooper, Lindsay Crate, John Emery, Kathryn James, Hannah King, Paul Martin, Stefano S. Catenacci, Rob Bomont, Paul Smith, Sara Mele, Alessandra Verzelloni, Philippa Dix, Graham Bell, Elena Gordeva, Lesley McKee, Esther Ngan, Jutta Scheffczik, Li-En Tan, Mark Worrall, Carmel Cassar, Kevin Goddard, Victoria Barlow, Vimmi Oshan, Khairi Shah, Sarah Bell, Lisa Daniels, Monica Gandhi, David Pachter, Chris Perry, Andrew Robertson, Carmen Scott, Lynne Waring, David Barnes, Sophie Childs, Joanne Norman, Robin Sunderland, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anesthésiologie, Tampere University, Department of Prehospital Emergency Care, Pain Management and Anaesthesiology, Anesthesiology, APH - Quality of Care, ANS - Neuroinfection & -inflammation, Disma, Nicola, Veyckemans, Franci, Virag, Katalin, Hansen, Tom G., Becke, Karin, Harlet, Pierre, Vutskits, Laszlo, Walker, Suellen M., de Graaff, Jurgen C., Zielinska, Marzena, Simic, Dusica, Engelhardt, Thoma, Habre, Walid, Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johane, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Jori, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, Rene, Cajkova, Petra, Mixa, Vladimir, Sedlačkova, Yvona, Knoppova, Lenka, Zlamalova (nee Květoňova), Alena, Vavřina, Martin, Žurek, Jiři, Hansen, Tom, Afshari, Arash, Bille, Anders B., Ellekvist, Marguerite, Ilmoja, Mari-Lii, Moor, Reet, Kikas, Reet, Vali, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vahatalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugue, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Herve, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, Francoi, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cecile, Petry, Lea, Ros, Lilica, Zang, Aurelien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thoma, Fabre, Fanny, Legrand, Aurelien, Druot, Emilie, Orliaguet, Gille, Sabau, Lucie, Uhrig, Lynn, de la Briere, Francoi, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thoma, Diers, Anja, Schorer, Clemen, Weyland, Andrea, Cohausz, Ruth, Kretz, Franz-Josef, Loffler, Michaela, Wilbs, Marku, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthia, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thoma, Richter, Daniel, Schafer, Melanie, Weigand, Marku, Weiterer, Sebastian, Ochsenreiter, Miriam, Scholer, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicola, Menzel, Christoph, Trieschmann, Uwe, Yucetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Sohle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemi, Tsiotou, Adelai, Sapi, Erzsebet, Szekely, Edgar, Kosik, Nandor, Maraczi, Veronika, Schnur, Jano, Csillag, Judit, Gal, Jano, Gobl, Gergely, Hauser, Balaz, Petroczy, Andra, Tovishazi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria C., Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura B., Finamore, Simona A., Porro, Giuliana A., Bonfiglio, Rachele, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald R., Favarato, Moreno, Locatelli, Bruno G., Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rient, Emal, Dina, Stevens, Marku, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andrea, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der, Anouk, Dortmont, Knijff-van, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella M., Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Ba, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger M., Isern, Erik R., Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Silvia, Patuleia, Maria Dominga, Esteves, Catarina C., Salgado, Helena, Santos, Maria J., Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyiri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanova, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela P., Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandstrom, Kerstin, Bengt, Sporre, Dorenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnstrom, Ann, Ponten, Emma, Bruelisauer, Thoma, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathia, Riva, Thoma, Seiler, Stefan, Bogli, Yann, Dolci, Mirko, Marcucci, Carine, Pichon, Isabelle, Casutt, Mattia, Holzle, Martin, Hurni, Thoma, Johr, Martin, Anna-Ursina, null, Malar, null, Mauch, Jacqueline, Erb, Thoma, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse C., Hatipoğlu, Zehra, Ozcengiz, Dilek, Erdost, Hale Aksu, Ocmen, Elvan, Olguner, Cimen, Ayanoglu, Hilmi, Dincer, Pelin C., Umuroglu, Tumay, Azizoglu, Mustafa, Birbicer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargi, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet W., Abbott, Joy, Armstrong, Jame, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano S., Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chri, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, HUS Children and Adolescents, Children's Hospital, and Clinicum

Subjects
Male, Time Factors, Health Status, Comorbidity, Intraoperative Complications/diagnosis/epidemiology/mortality/therapy, 0302 clinical medicine, Postoperative Complications, 030202 anesthesiology, Risk Factors, patient safety, Medicine, Anesthesia, Prospective Studies, Prospective cohort study, Intraoperative Complications, Medical Audit, ddc:617, Incidence (epidemiology), Incidence, Age Factors, Gestational age, critical events, Europe, Anesthetics/adverse effects, quality, Surgical Procedures, Operative, outcome, Female, Infant, Premature, Gestational Age, Anesthesia/adverse effects/mortality, Risk Assessment, Europe/epidemiology, 03 medical and health sciences, Humans, Anesthetics, business.industry, Postoperative Complications/diagnosis/epidemiology/mortality/therapy, Postmenstrual Age, Infant, Newborn, Infant, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, neonates, Clinical trial, Surgical Procedures, Operative/adverse effects/mortality, Anesthesiology and Pain Medicine, Blood pressure, Observational study, critical event, neonate, business
Abstract

Background: Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown. Methods: This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. The primary aim was to identify thresholds of pre-determined physiological variables that triggered a medical intervention. The secondary aims were to evaluate morbidities, mortality at 30 and 90 days, or both, and associations with critical events. Results: Infants (n=5609) born at mean (standard deviation [SD]) 36.2 (4.4) weeks postmenstrual age (35.7% preterm) underwent 6542 procedures within 63 (48) days of birth. Critical event(s) requiring intervention occurred in 35.2% of cases, mainly hypotension (>30% decrease in blood pressure) or reduced oxygenation (SpO2

Published
2021

25. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Walid Habre, Nicola Disma, Katalin Virag, Karin Becke, Tom G Hansen, Martin Jöhr, Brigitte Leva, Neil S Morton, Petronella M Vermeulen, Marzena Zielinska, Krisztina Boda, Francis Veyckemans, Walter Klimscha, Regina Konecny, Robert Luntzer, Ulrike Morawk-Wintersperger, Franz Neiger, Lydia Rustemeyer, Christian Breschan, Denise Frey, Manuela Platzer, Reinhard Germann, Joachim Oeding, Birgit Stoegermüller, Bernhard Ziegler, Philipp Brotatsch, Anton Gutmann, Gerlinde Mausser, Brigitte Messerer, Wolfgang Toller, Maria Vittinghoff, Gregor Zangl, Natascha Seidel-Ahyai, Christoph Hochhold, Ruth Kroess, Peter Paal, Steven Cnudde, Patricia Coucke, Birgit Loveniers, John Mitchell, David Kahn, Thierry Pirotte, Caroline Pregardien, Marc Coppens, Stefan De Hert, Björn Heyse, Martine Neckebroek, Aliaksandra Parashchanka, Jurgen Van Limmen, Nancy Van Den Eynde, Caroline Vanpeteghem, Piet Wyffels, Michaël Lalot, Jean-Paul Lechat, France Stevens, Sari Casaer, Françoise De Groote, Françoise De Pooter, Andrée De Villé, Marc Gerin, Natalia Magasich, Cristel Sanchez Torres, Denise Van Deenen, Johan Berghmans, Dirk Himpe, Eva Roofthooft, Ellen Joukes, Carine Smitz, Veronique Van Reeth, Christel Huygens, Julie Lauweryns, Karen De Smet, Nadia Najafi, Jan Poelaert, Anne Van de Velde, Veerle Van Mossevelde, Ivan Bekavac, Diana Butkovic, Dubravka Heli Litvic, Ivana Kerovec Soric, Hrvoje Maretic, Djurdjica Moscatello, Ljiljana Popovic, Slobodan Micici, Ivana Stuck Tus, Lada Kalagac Fabris, Tatjana Simurina, Nina Sulen, Gordana Kesic-Valpotic, Dajana Djapic, Jirí Žurek, Lucie Jureckova, Iveta Mackova, Monika Skacel, Stanislava Weinlichova, Jan Divák, Michal Frelich, René Urbanec, Vera Biskupova, Vladimir Mixa, Jana Pavlickova, Arash Afshari, Morten Bøttger, Marguerite B. Ellekvist, Mathias Johansen, Birgitte Ingeborg Madsen, Jens Christian Nilsson, Birgitte MB Schousboe, Nicola G. Clausen, Tom G. Hansen, Nick Phaff Steen, Mari-Liis Ilmoja, Virge Tonise, Juri Karjagin, Reet Kikas, Mika Isohanni, Anniina Lyly, Annika Takala, Johanna Happo, Kai Kiviluoma, Kati Martikainen, Riku Aantaa, Tuula Manner, Sanna Vilo, Catherine Amory, Hugues Ludot, Patricia Lambotte, René Busche, Olivier Jacqmarcq, Corinne Lejus, Julien Corouge, Christian Erb, Delphine Garrigue, Patricia Gillet, Anne Laffargue, Veronique Lambelin, Hélène Le Freche, Daliana Peresbota, Pierre Richart, Jerome Berton, Catherine Chapotte, Laurent Colbus, Thierry Lehousse, Jean Monrigal, Catherine Baujard, Philippe Roulleau, Giuseppe Staiti, Hélène Batoz, Maryline Bordes, Anne Didier, Yann Hamonic, Sylvaine Lagarde, Karine Nouette-Gaulain, François Semjen, Brigitte Zaghet, Jacky Dekens, Axelle Delcuze, Hervé Dupont, Aurélien Legrand, Celine Raffoflandreur, Noémie Audren, Blandine Camus, Marielle Cartal, Chantal Chazelet, Isabelle Davin, Marion Guillier, Luc Desjeux, Claire Larcher, Elodie Grein, Mickeal Leclercq, Roxana Levitchi, Lilica Rosu, Dominique Simon, Aurélien Zang, Anne Migeon, Anne-Charlotte Gagey, Nathalie Bourdaud, Anne-Charlotte Carre, Frédéric Duflo, Jean-Claude Riche, Philippe Robert, Emilie Druot, Olivier Maupain, Gilles Orliaguet, Lucie Sabau, Hanna Taright, Lynn Uhrig, Juliette Verchere-Montmayeur, Lise Debrabant, Clotaire Pilla, Alexandre Podvin, Benjamin Roth, Souhayl Dahmani, Florence Julien-Marsollier, Nada Sabourdin, Bogdan Alexandri, Gilles Brezac, Francois de la Brière, Catherine Hayem, Elizabeth Lhubat, Jean Paul Mission, Charlotte Rémond, Christophe Dadure, Maud Maniora, Anais Marie, Philippe Pirat, Anne-Charlotte Saour, Chrystelle Sola, Claude Ecoffey, Eric Wodey, Christian Adam, Thomas Standl, Ehrenfried Schindler, Tomohiro Yamamoto, Michael Brackhahn, Christoph Bernhard Eich, Holger Guericke, Petra Kindermann, Michael Laschat, Cornel Schink, Frank Wappler, Claudia Hoehne, Natalia Skordou, Johanna Ulrici, Martin Jetzek-Zader, Peter Kienbaum, Tanja Meyer-Treschan, Olaf Picker, Maximilian S. Schaefer, Golo Mielke, Sabine Baethge, Axel Ramminger, Martin Bauer, Matthias Bollinger, José Hinz, Michael Quintel, Sebastian G. 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Giusi, Almenrader, Nicole, Aurilio, Caterina, Sansone, Pasquale, Albarello, Raffaella, Bracci, Paolo, Cecini, Mariateresa, Cristina Mondardini, Maria, Pasini, Lorena, Vason, Milo, Zani, Gianluca, Zoppellari, Roberto, Pistidda, Laura, Cortegiani, Andrea, Maurizio Raineri, Santi, Hasani, Antigona, Hashimi, Medita, Ancupans, Agri, Barzdina, Arta, Straume, Zane, Zundane, Anda, Chlopin, Mikhail, Gestautaite, Dalia, Lukosiene, Laura, Paliokaite, Evelina, Razlevice, Ilona, Armoniene, Inesa, Bernotiene, Aurelija, Daugelavicius, Viduna, Dockiene, Ilona, Gaidelyte, Lina, Saviciene, Nijole, Krikstaponiene, Jolita, Sidlovskaite Baltake, Dominika, Stasevski, Vladyslav, Vaitoskaite, Agne, Gatt, David, Mifsud, Stephanie, Zammit, Simone, Allison, Celia, Aslami, Hamid, Eberl, Susanne, van Stijn, Mireille F. M, Stevens, Markus F, Punt, Kee, van Osch, Rob, Bauwman, Arthur, Scholten, Harm, Svircevic, Vesna, Adriaens, Veronique, Dirckx, Maaike, Dogger, Jaap, Dons Sinke, Ilse, Machotta, Andrea, Moors, Xavier, Rad, Mandana, Staals, Lonneke, Van, der Knijff, van der Marel, Caroline, Sieben, Anne, van der Zwan, Tim, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Engel, Nicole, Vossen, Carine, Mahadewsing, Ravin, Meijer, Patrick, Gerling, Volker, van der Schatte Olivier, Roelof, van Doorn, Thea, Vons Mark Hendriks, Kristy, Lako, Sandra, jan Scheffer, Gert, Tielens, Luc, Voet, Marieke, Absalom, Anthony, Bergsma, Margot, Spanjer, Vera, Spanjersberg, Rob, van de Riet, Yvette, Volkers, Martin, de Graaff, Jurgen C., Hopman, Geranne A. J., Kappen, Teus H., Hannie, J., Megens, A. M., Numan, Sandra C., Schouten, Anton N. J., Turner, Nigel M., Van Der Werff, Désirée B. M., Wensing, Renee T. M., Ephraim, Erik, Nolte, Claire, Reikvam, Tore, Fredrik Lund, Ole, Skaaden, Lene, Marthe Ballovarre, Kari, Bakken Boerke, Wenche, Grindheim, Guro, Lindenskov, Pal H. H, Beate Solas, Anne, Sponheim, Sjur, Ullensvang, Kyrre, Viken, Oddbjorn, Marie Drage, Inger, Gymoese Berthelsen, Kasper, Anders Kroken, Bjørn, Bergland, Unni, Pryzmont, Miroslaw, Talalaj, Mariola, Wasiluk, Malgorzata, Zalewska, Dorota, Damps, Maria, Siemek Mitela, Jadzia, Wieczorek, Pawel, Juzwa, Magdalena, Rosada Kurasinska, Jowita, Bartkowska Sniatkowska, Alicja, Cettler, Maciej, Kopycinska, Renata, Rudewicz, Iwona, Sobczyk, Jaek, Wojciechowski, Dariusz, Baranowski, Artur, Basiewicz, Ewa, Mierzewska Schmidt, Magdalena, Retka, Wlodzimierz, Sawicki, Piotr, Checinska, Magdalena, Zurawska, Magdalena, Leal, Teresa, Mascarenhas, Catia, Pedro Pina, António, Joao Susano, Maria, Moniz, Antonio, Teresa Rocha, Maria, Calvao Santos, Carolina, Domingas Patuleia, M., Pereira, Ricardo, Roxo, Helena, Amaral, Rosa, Guedes, Isabel, Gomes, Cristina, Gonçalves, Marta, Salgado, Helena, Santos, Maria, Rodrigues, Sara, Sa, Angela, Machado, Elvira, Pé d'Arca, Sandra, Seabra, Manuel, Mihaela Gheorghe, Ligia, Ivascu, Constantin, Moraru Draghici, Lucia, Suvejan, Mirela, Babici, Remu, Eniko, Kovac, Hogea, Cristiana, Mihaela, Dubau, Nicoleta, Daraban, Barbunc, Danut, Maria Nistor, Alina, Stefan, Violeta, Catalina Ionescu, Gabriela, Davidescu, Irina, Teodora Nastase, Alina, Dumitru Rusu, Florin, Badarau, Victoria, Cindea, Iulia, Moscaliuc, Melania, Olteanu, Dana, Petrescu, Luxita, Ceuca, Daniela, Galinescu, Irena, Badeti, Rodica, Capusan, Alin, Cucui Cozma, Cosmina, Popescu, Barbura, Cimpeanu, Luminita, Birliba, Mihaela Petronela, Miulescu, Magdalena, Balamat, Stefania, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Pick, Darina, Sirghie, Rodica, Tabacaru, Radu, Trante, Irinel, Horhota, Lucian, Bandrabur, Daniela, Ciobanu, Tudor, Cuciuc, Veaceslav, Munteanu, Valentin, Olaru, Valentin, Paiu, Corneliu, Savu, Anca, Trifan, Oana, Elena Malos, Anca, Glazunov, Anton, Ivanov, Alexander, Poduskov, Evgeny, Popov, Alexander, Guskov, Igor, Lugovoy, Alexander, Nechaev, Vladislav, Ovezov, Alexey, Basov, Mikhail, Kochkin, Vladimir, Lazarev, Vladimir, Chizhov, Dmitri, Ostreikov, Ivan, Tolasov, Konstantin, Budic, Ivana, Marjanovic, Vesna, Draskovic, Biljana, Pandurov, Marina, Simin, Jovana, Dolinaj, Vladimir, Janjevic, Dusanka, Mandras, Ana, Mircetic, Maja, Petrovic, Sladjana, Rebac, Vlatka, Slavkovic, Bojana, Stevanovic, Vesna, Velcev, Ana, Knezevic, Mirjana, Milojevic, Irina, Puric, Selena, Simic, Irena, Stevic, Marija, Stranjanac, Vladimir, Simic, Dusica, Cabanova, Barbora, Hanula, Miloslav, Grynyuk, Andry, Berger, Jelena, Cerne, Uro, Nastran, Andraz, Pirc, Dejan, Popic, Rok, Stupnik, Spela, Rubio, Paloma, del Río, Cristina, Benito, Pilar, Pino, Gema, Gutierrez, Ignacio, Gutierrez Valcarcel, Andrea, León Carsi, Irene, Perez Garcia, Anibal, López Galera, Sílvia, Marco Valls, Joan, Ricol Lainez, Laura, Vallejo Tarrat, Andrea, Artes, David, Banus, Ester, Chirichiello, Luca, De Abreu, Leidy, De Josemaria, Belen, Helena Gaitan, M., Garces, Antonio, Lazaro, Juan J, Manen Berga, Ferran, Molies, Dolor, Monclus, Enric, Navaro, Montserrat, Pamies, Carmen, Perelló, Marina, Prat, Mar, Ribo, Laura, Angeles Sanz, M., Serrano, Silvia, Sola Ruiz, Eva, Anuncia Escontrela Rodríguez, Blanca, Maria Gago Martinez, Andrea, Martínez Ruiz, Alberto, De La Cruz Benito, Fausto, Gabilondo Garcia, Gustavo, Martinez Maldonado, Ever, Noriega, Bryant, Oller Duque, Lara, Olmos Mendez, Alberto, Perez Ferrer, Antonio, Reinoso Barbero, Francisco, Acevedo Bambaren, Ismael, Domínguez, Fernando, Franco, Teresa, Jiménez, Anabel, Melero, Alicia, Feliu, Montserrat, García, Irene, Montferrer, Núria, Munar, Francisca, Muro, Cristina, Nuño, Rosario, Perera, Remel, Schmucker, Erika, Börjesson, Glenda, Gillberg, Lar, Castellheim, Albert, Sandström, Kerstin, Bauer, Annette, Roos, Torbjörn, Hedlund, Lar, Boegli, Yann, Dolci, Mirko, Marcucci, Carine, Spahr Schopfer, Isabelle, Pellegrini, Michel, Book, Malte, Errass, Loreen, Riggenbach, Christine, Casutt, Mattia, Hölzle, Martin, Hurni, Thoma, Mauch, Jacqueline, Anselmi, Luciano, Anselmi, Irene, Jacomet, Alfred, Oberhauser, Marku, Wossner, Stephanie, Zettl, Angelika, Erb, Thoma, Mackiewicz, Tomasz, Simitzes, Helena, Ozer, Yetkin, Takil, Arzu, Alanoglu, Zekeriyya, Bermede, Onat, Cakar Turhan, K. Sanem, Alkis, Neslihan, Yildirim Guclu, Cigdem, Ceyda Meco, Basak, Hatipoglu, Zehra, Ozcengiz, Dilek, Begec, Zekine, Ilksen Toprak, Huseyin, Kendigelen, Pinar, Cigdem Tütüncü, Ayse, Karadeniz, Meltem Savran, Seyhan Ozkan, Tulay, Sivrikoz, Nuket, Kemal Arslantas, Mustafa, Hizal, Ayse, Tore Altun, Gülbin, Umuroglu, Tumay, Baris, Sibel, Kazak Bengisun, Zuleyha, Goncharenko, Galyna, Khrapak, Maksym, Klymenko, Tetyana, Pavlenko, Vitaliy, Prysiazhniuk, Dmytro, Rudio, Olga, Varyvoda, Mykhailo, Vodianytskyi, Sergii, Boryshkevych, Ivanna, Kyselova, Iryna, Trikash, Nikolay, Albokrinov, Andrew, Perova Sharonova, Valentina, Sklyar, Vitaliy, Surkov, Deni, Abdelaal, Amr, Barber, Nicola, Checuti, Sarah, Godsiff, Leisha, Johanne, Lynch, Simpson, Joanna, Underhill, Helen, Diwan, Rishi, Kelgeri, Nivedita, Masip, Nuria, Ravi, Radha, Roberts, Steve, Cillis, Annagrazia, Marcus, Ritchie, Merella, Federica, Love, David, Baraggia, Paolo, Bird, Victoria, Hussey, Joseph, Alderson, Peter, Bartholomew, Karen, Moncreiff, Michael, Davidson, Sarah, Hare, Alison, Kotecha, Ami, Lee, Corina, Liyanage, Ganga, Patel, Shivali, Samani, Amee, Abou Samra, Mark, Boyd, Matthew, Hullatt, Laurence, Levy, David, Pauling, Mark, Sharman, Sarah Jane, Smith, Natalie, Rutherford, John, Cavalier, Alison, Locke, Christie, Sage, Frederic, Bapat, Smita, Hammerschlag, Jacinda, Ioannou, Ioanni, King, Stephanie, Pegg, Rachel, Salota, Vishal, Sketcher, Jonathan, Thadsad, Muthu, Zeitlin, Deborah, Jack, Ewan, Lang, Colin, Ahmed, Samira, Ayyash, Reema, Bari, Francoise, Bell, Sarah J, Elizabeth Biercamp, Claire, Briggs, Sandra, Gabriella Elena Clement, Maria, Dalton, Mark, Ali Eissa Eid, Mohamed, Gandhi, Monica, Harmen Herrema, Idse, Khaffaf, Ranj, Jeng Min Law, Savio, Mcclintock, Joanna, Ireland, Nichola, Majid Saleem, Mohammed, Smith, Fiona, Cohen, Marc, Lee, Clover Ann, O'Donahue, Lizanne, Powell, Alex, Rawlinson, Ellen, Snoek, Aarjan, Weiss, Katja, Wellesley, Hugo, Crawford, Michael, Abdel Hafiz, Mostafa, Day, Alexandra, Rajamani, Balaji, Saha, Rita, Wright, Dave, Chee, Lew Chin, Bew, Stephanie, Homer, Rachel, Malarkkan, Nalini, Wolfe Barry, Juliet, Angadi, Pradeep, Cagney, Brid, De Melo, Eric, Dekker, Elsa, Helm, Emma, Jones, Gareth, Peiris, Kawshala, Russell, William, Slater, Patricia, Sodhi, Puja, Browning, Mike, Phillips, Trudie, Van Hecke, Rachel, Muir, Vimty, Singh, Piyush, Soskova, Tereza, Cumming, Craig, Farquharson, Pamela, Pearson, Karen, Shaw, Neil, Whiteside, Jonathan, Whyte, Emma, Byers, Gordon, Davies, Kay, Engelhardt, Thoma, Faliszewski, Isabella, Johnston, Graham, Kaufmann, Nil, Kusnirikova, Zuzana, Wilson, Graham, Carachi, Peter, Makin, Andrew, Foster, Brian, Lipczynski, Dariusz, Mawer, Rebecca, Rutherford, William, Rogerson, David, Rushman, Sarah, Taylor, Christopher, Tomlinson, William, Dix, Philippa, Woodward, Tom, Bell, Graham, Boyle, David, Cloherty, Marianne, Cullen, Julia, Cullen, Pauline, Fairgrieve, Ro, Ghent, Robert, Glasgow, Russell, Gordeeva, Elena, Harden, Alison, Hivey, Sarah, Jerome, Kevin, Mckee, Lesley, Morton, Neil, Pribul, Vicky, Sinclair, John, Steiner, Maria, Steward, Heather, Sweeney, Lorraine, Thomson, Wendy, Whiteside, Jeanette, Dalton, Andrew, Ross, Mark, Smith, Carolyn, Allen, Claire, Anders, Nicola, Barlow, Victoria, Bassett, Mike, Darwin, Leanne, Davison, Rachel, Diacono, Jacque, Hobbs, Amy, Hutchinson, Adel, Lomas, Bernadette, Lonsdale, Hannah, Nasser, Leila, Oshan, Vimmi, Patel, Pradip, Raistrick, Christopher, Scott Warren, Victoria, Talbot, Laura, Wai, Carolynn, Childs, Sophie, Dickinson, Matthew, Bloomfield, Tom, Garrioch, Sweyn, Watson, Karen, Gaynor, Jame, Harrison, Richard, Lee, Juliette, Blythe, Elizabeth, Dorman, Teresa, Eissa, Ayman, Ellwood, Jame, Gooch, Ingrid, Hearn, Robert, Hodgetts, Vanessa, John, Robert, Kirton, Christine, Ladak, Nadia, Morgan, Judith, Plant, Nina, Shepherd, Elizabeth, Short, Judith, Stack, Charle, Steel, Simon, Taylor, Matthew, Thomas, Deborah, Wilson, Catharine, Wilson Smith, Elaine, Bradbury, Carol L., Hussain, Nageena, Mayell, Antonia, Mesbah, Ahmed, Qureshi, Arif, Vaidyanath, Chandra, Geary, Tim, Hawksworth, Chri, Parasuraman, Tamaraichelvi, Perry, Nicole, Banerjee, Indrani, Barr, Katharine, Butler, Patrick, Davies, Jack, Flewin, Lisa, Gande, Richard, Montague, Jame, Plumb, Jame, Pratt, Thoma, Sutherland, Paul, Vail, Hannah, Wilkins, Andrew, Hunter, Catherine, Russell, Susan, Thomas, Alun, Mifsud, Mark, Strachan, Dominic, Plichon, Benoit, Harlet, Pierre, Child and Adolescent Psychiatry / Psychology, Morawk-Wintersperger, Ulrike, Seidel-Ahyai, Natascha, Lechat, Jean-Paul, Kesic-Valpotic, Gordana, Ilmoja, Mari-Lii, Nouette-Gaulain, Karine, Gagey, Anne-Charlotte, Carre, Anne-Charlotte, Riche, Jean-Claude, Verchere-Montmayeur, Juliette, Julien-Marsollier, Florence, Saour, Anne-Charlotte, Jetzek-Zader, Martin, Meyer-Treschan, Tanja, Preussler, Niels-Peter, Sidlovskaite-Baltake, Dominika, van Stijn, Mireille F M, Dons-Sinke, Ilse, van der Knijff - van Dortmont, Anouk, Hopman, Geranne A.J., Megens, A.M., Schouten, Anton N.J., Van Der Werff, Désirée B.M., Wensing, Renee T.M., Lindenskov, Pal H H, Siemek-Mitela, Jadzia, Rosada-Kurasinska, Jowita, Bartkowska-Sniatkowska, Alicja, Mierzewska-Schmidt, Magdalena, Moraru-Draghici, Lucia, Cucui-Cozma, Cosmina, Birliba, Mihaela-Petronela, Perez- Ferrer, Antonio, Spahr-Schopfer, Isabelle, Cakar Turhan, K.Sanem, Perova-Sharonova, Valentina, Abou-Samra, Mark, Sharman, Sarah-Jane, McClintock, Joanna, Lee, Clover-Ann, Abdel-Hafiz, Mostafa, Chee, Lew-Chin, McKee, Lesley, Scott-Warren, Victoria, and Wilson-Smith, Elaine

Subjects
Male, Pediatrics, Health Status, OPERATING-ROOM, Respiratory Tract Diseases, CHILDREN, 0302 clinical medicine, REGIONAL ANESTHESIA, Postoperative Complications, 030202 anesthesiology, CARDIAC-ARREST, Medicine, General anaesthesia, Prospective Studies, Prospective cohort study, Child, Intraoperative Complications, COMPLICATIONS, ddc:617, Incidence (epidemiology), Mortality rate, musculoskeletal, neural, and ocular physiology, Incidence, Age Factors, Hospitals, Europe, Cardiovascular Diseases, Child, Preschool, RESPIRATORY ADVERSE EVENTS, Female, Clinical Competence, Cohort study, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, macromolecular substances, Anesthesia, General, Drug Hypersensitivity, 03 medical and health sciences, MORBIDITY, Journal Article, Humans, business.industry, Infant, Newborn, Infant, 030208 emergency & critical care medicine, Perioperative, nervous system, PROSPECTIVE COHORT, Relative risk, RISK-FACTORS, Observational study, Human medicine, Nervous System Diseases, business, SYSTEM
Abstract

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0–5·5) with an incidence of respiratory critical events of 3·1% (2·9–3·3). Cardiovascular instability occurred in 1·9% (1·7–2·1), with an immediate poor outcome in 5·4% (3·7–7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86–0·90; p

Published
2017

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