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1. Biological basis of extensive pleiotropy between blood traits and cancer risk

Author

Pardo-Cea, Miguel Angel, Farré, Xavier, Esteve, Anna, Palade, Joanna, Espín, Roderic, Mateo, Francesca, Alsop, Eric, Alorda, Marc, Blay, Natalia, Baiges, Alexandra, Shabbir, Arzoo, Comellas, Francesc, Gómez, Antonio, Arnan, Montserrat, Teulé, Alex, Salinas, Monica, Berrocal, Laura, Brunet, Joan, Rofes, Paula, Lázaro, Conxi, Conesa, Miquel, Rojas, Juan Jose, Velten, Lars, Fendler, Wojciech, Smyczynska, Urszula, Chowdhury, Dipanjan, Zeng, Yong, He, Housheng Hansen, Li, Rong, Van Keuren-Jensen, Kendall, de Cid, Rafael, and Pujana, Miquel Angel

Published
2024
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3. Persistent varices in cured patients: Understanding the role of hepatic venous pressure gradient

Author

Pol Olivas, Alexandre Soler-Perromat, Luis Tellez, José Antonio Carrión, Edilmar Alvarado-Tapias, José Ferrusquía-Acosta, Sabela Lens, Antonio Guerrero, Ángeles Falgà, Pamela Vizcarra, Lara Orts, Valeria Perez-Campuzano, Sarah Shalaby, Sonia Torres, Anna Baiges, Fanny Turon, Juan Carlos García-Pagán, Ángeles García-Criado, and Virginia Hernández-Gea

Subjects
Portal hypertension, Etiologic factor removal, WHVP, Cirrhosis regression, Cirrhosis recompensation, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Etiologic factor removal (ER) drives recompensation and improves portal hypertension in cirrhosis. Esophageal varices (EV) and portosystemic shunts (PSS) have been found in patients despite hepatic venous pressure gradient (HVPG) dropping below 10 mmHg after ER, questioning HVPG accuracy in reflecting true portal pressure in the setting of ER. We aim to evaluate the correlation of HVPG with direct portal pressure (DPP) in patients with persistence of EV after ER despite HVPG

Published
2024
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4. La mejora de la competencia digital docente, avanzando hacia la madurez digital institucional: una revisión sistemática

Author

Aida Ralda Baiges, José Luis Lázaro-Cantabrana, and Josep Holgado García

Subjects
competencia digital docente, alfabetización tecnológica, madurez digital, educación primaria, Theory and practice of education, LB5-3640
Abstract

Las tecnologías digitales (TD) están transformando la educación, exigiendo a los docentes desarrollar competencias digitales. La madurez digital de las instituciones educativas es cada vez más importante con la integración de las TD en las estrategias y prácticas docentes. El objetivo del estudio es definir acciones e identificar ámbitos de actuación para mejorar la Competencia Digital Docente (CDD) y avanzar hacia la madurez digital. La revisión está basada en el modelo PRISMA entre 2017 y enero 2023. Las bases de datos utilizadas son WoS, Scopus y ERIC. Después de aplicar los criterios, la muestra es de 25 artículos. Las siete líneas de acción para mejorar la CDD son la formación, la autoeficacia, la evaluación, la integración de la Competencia Digital (CD), el asesoramiento, la reflexión y la integración en el currículo. Para avanzar en la madurez digital se distinguen cuatro ámbitos a tener en cuenta: CD del alumnado, CDD, gestión de recursos e infraestructura y gestión del centro educativo.

Published
2024
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6. Persistent varices in cured patients: Understanding the role of hepatic venous pressure gradient

Author

Olivas, Pol, Soler-Perromat, Alexandre, Tellez, Luis, Carrión, José Antonio, Alvarado-Tapias, Edilmar, Ferrusquía-Acosta, José, Lens, Sabela, Guerrero, Antonio, Falgà, Ángeles, Vizcarra, Pamela, Orts, Lara, Perez-Campuzano, Valeria, Shalaby, Sarah, Torres, Sonia, Baiges, Anna, Turon, Fanny, García-Pagán, Juan Carlos, García-Criado, Ángeles, and Hernández-Gea, Virginia

Published
2024
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9. Biological basis of extensive pleiotropy between blood traits and cancer risk

Author

Miguel Angel Pardo-Cea, Xavier Farré, Anna Esteve, Joanna Palade, Roderic Espín, Francesca Mateo, Eric Alsop, Marc Alorda, Natalia Blay, Alexandra Baiges, Arzoo Shabbir, Francesc Comellas, Antonio Gómez, Montserrat Arnan, Alex Teulé, Monica Salinas, Laura Berrocal, Joan Brunet, Paula Rofes, Conxi Lázaro, Miquel Conesa, Juan Jose Rojas, Lars Velten, Wojciech Fendler, Urszula Smyczynska, Dipanjan Chowdhury, Yong Zeng, Housheng Hansen He, Rong Li, Kendall Van Keuren-Jensen, Rafael de Cid, and Miquel Angel Pujana

Subjects
Blood trait, Cancer, Eosinophil, Hematopoiesis, Myeloid, Pleiotropy, Medicine, Genetics, QH426-470
Abstract

Abstract Background The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations. Methods Multivariate Cox regression was used to evaluate associations between blood traits and cancer diagnosis in cases in the UK Biobank. Shared genetic variants were identified from the summary statistics of the genome-wide association studies of 27 blood traits and 27 cancer types and subtypes, applying the conditional/conjunctional false-discovery rate approach. Analysis of genomic positions, expression quantitative trait loci, enhancers, regulatory marks, functionally defined gene sets, and bulk- and single-cell expression profiles predicted the biological impact of pleiotropic variants. Plasma small RNAs were sequenced to assess association with cancer diagnosis. Results The study identified 4093 common genetic variants, involving 1248 gene loci, that contributed to blood–cancer pleiotropism. Genomic hotspots of pleiotropism include chromosomal regions 5p15-TERT and 6p21-HLA. Genes whose products are involved in regulating telomere length are found to be enriched in pleiotropic variants. Pleiotropic gene candidates are frequently linked to transcriptional programs that regulate hematopoiesis and define progenitor cell states of immune system development. Perturbation of the myeloid lineage is indicated by pleiotropic associations with defined master regulators and cell alterations. Eosinophil count is inversely associated with cancer risk. A high frequency of pleiotropic associations is also centered on the regulation of small noncoding Y-RNAs. Predicted pleiotropic Y-RNAs show specific regulatory marks and are overabundant in the normal tissue and blood of cancer patients. Analysis of plasma small RNAs in women who developed breast cancer indicates there is an overabundance of Y-RNA preceding neoplasm diagnosis. Conclusions This study reveals extensive pleiotropism between blood traits and cancer risk. Pleiotropism is linked to factors and processes involved in hematopoietic development and immune system function, including components of the major histocompatibility complexes, and regulators of telomere length and myeloid lineage. Deregulation of Y-RNAs is also associated with pleiotropism. Overexpression of these elements might indicate increased cancer risk.

Published
2024
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10. Las nuevas formas de hábitat ibérico en los siglos III y II a. C. y la irrupción del mundo romano en el yacimiento del Turó de Peralada (Peralada, Girona)

Author

Jaume Puigredon Boixadera, Arnau Sirvent Ferrés, and Montse Baiges Minguella

Subjects
turó de peralada, contexto doméstico, ibérico pleno-tardío, brasero de bronce, Prehistoric archaeology, GN700-890, Auxiliary sciences of history, Archaeology, CC1-960
Abstract

Las últimas excavaciones realizadas en la parte baja del Turó de Peralada han puesto al descubierto dos nuevas viviendas del Ibérico Pleno y Tardío que modifican la interpretación que se tenía actualmente del hábitat doméstico de este período en el yacimiento. Por esta razón, con base en estas nuevas evidencias y su posterior abandono intencionado a mediados del siglo I a. C. por la irrupción del mundo romano, se evidencian importantes cambios en el Turó de Peralada de los cuales hasta ahora se tenían muy pocos datos.

Published
2023
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11. Porto-sinusoidal vascular disorder in chronic HBV: A significant coexistence not to be overlooked

Author

Pol Olivas, Valeria Perez-Campuzano, Lara Orts, Carla Montironi, Marta Magaz, Pablo Ruiz, Sarah Shalaby, Asunción Ojeda, Pau Rosich, Anna Baiges, Fanny Turon, Sabela Lens, Juan Carlos García Pagán, and Virginia Hernández-Gea

Subjects
Porto-Sinusoidal Vascular Disease, Non-cirrhotic Portal Hypertension, Vascular liver diseases, Idiopathic portal hypertension, Chronic Hepatitis B, Obliterative portal venopathy, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Porto-sinusoidal vascular disorder (PSVD) encompasses a group of liver diseases with vascular abnormalities that can cause portal hypertension in the absence of cirrhosis. The new diagnostic criteria allow for coexistence with other liver diseases, however its relationship with chronic hepatitis B (CHB) remains unclear. This study aimed to assess HBV prevalence in a PSVD cohort and evaluate its clinical impact. Methods: This retrospective study was conducted on patients with PSVD at Hospital Clínic Barcelona. HBV serology was evaluated, and patients were categorized into HBV chronic infection, past infection, or no HBV exposure. Clinical characteristics and outcomes were compared. Results: We included 155 patients with PSVD. Prevalence of CHB and past HBV infection in patients with PSVD was higher than in the general population (5.8% vs. 0.5%, p

Published
2024
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13. Laparoscopic Sleeve Gastrectomy in Patients with Severe Obesity Restores Adaptive Responses Leading to Nonalcoholic Steatohepatitis

Author

Cabré, Noemí, Luciano-Mateo, Fedra, Chapski, Douglas J, Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Castañé, Helena, Rodríguez-Tomàs, Elisabet, París, Marta, Sabench, Fàtima, Del Castillo, Daniel, del Bas, Josep M, Tomé, Mercedes, Bodineau, Clément, Sola-García, Alejandro, López-Miranda, José, Martín-Montalvo, Alejandro, Durán, Raúl V, Vondriska, Thomas M, Rosa-Garrido, Manuel, Camps, Jordi, Menéndez, Javier A, and Joven, Jorge

Subjects
Biochemistry and Cell Biology, Biological Sciences, Obesity, Clinical Research, Liver Disease, Chronic Liver Disease and Cirrhosis, Human Genome, Digestive Diseases, Biotechnology, Genetics, Hepatitis, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Gastrectomy, Humans, Ketoglutaric Acids, Laparoscopy, Non-alcoholic Fatty Liver Disease, Obesity, Morbid, TOR Serine-Threonine Kinases, bariatric surgery, DNA methylation, energy metabolism, epigenetics, functional studies, glutaminolysis, multi-omics approach, Other Chemical Sciences, Other Biological Sciences, Chemical Physics, Biochemistry and cell biology, Microbiology, Medicinal and biomolecular chemistry
Abstract

The surgically induced remission of liver disease represents a model to investigate the signalling processes that trigger the development of nonalcoholic steatohepatitis with the aim of identifying novel therapeutic targets. We recruited patients with severe obesity with or without nonalcoholic steatohepatitis and obtained liver and plasma samples before and after laparoscopic sleeve gastrectomy for immunoblotting, immunocytochemical, metabolomic, transcriptomic and epigenetic analyses. Functional studies were performed in HepG2 cells and primary hepatocytes. Surgery was associated with a decrease in the inflammatory response and revealed the role of mitogen-activated protein kinases. Nonalcoholic steatohepatitis was associated with an increased glutaminolysis-induced production of α-ketoglutarate and the hyperactivation of mammalian target of rapamycin complex 1. These changes were crucial for adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-driven pathways that modulated hepatocyte survival by coordinating apoptosis and autophagy and affected methylation-related epigenomic remodelling enzymes. Hepatic transcriptome signatures and differentially methylated genomic regions distinguished patients with and without steatohepatitis. Our results suggest that the increased glutaminolysis-induced α-ketoglutarate production and the mammalian target of rapamycin complex 1 dysregulation play a crucial role in the inefficient adaptive responses leading to steatohepatitis in obesity.

Published
2022

14. Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis

Author

Vidal-González, Judit, Martínez, Javier, Mulay, Akhilesh, López, Marta, Baiges, Anna, Elmahdy, Ahmed, Lampichler, Katharina, Maleux, Geert, Chang, Johannes, Poncela, Marta, Low, Gavin, Ghigliazza, Gabriele, Zipprich, Alexander, Picón, Carmen, Shah, Rushabh, Llop, Elba, Darnell, Anna, Maurer, Martin H., Bonne, Lawrence, Ramón, Enrique, Quiroga, Sergi, Abraldes, Juan G., Krag, Aleksander, Trebicka, Jonel, Ripoll, Cristina, La Mura, Vincenzo, Tandon, Puneeta, García-Martínez, Rita, Praktiknjo, Michael, Laleman, Wim, Reiberger, Thomas, Berzigotti, Annalisa, Hernández-Gea, Virginia, Calleja, José Luis, Tsochatzis, Emmanuel A., Albillos, Agustín, Simón-Talero, Macarena, and Genescà, Joan

Published
2024
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15. Impact of SARS-CoV-2 vaccination in patients with vascular liver diseases: Observations from a VALDIG multicenter study

Author

Perez-Campuzano, Valeria, Rautou, Pierre-Emmanuel, Marjot, Thomas, Praktiknjo, Michael, Alvarado, Edilmar, Turco, Laura, Ibáñez-Samaniego, Luis, González-Alayón, Carlos, Puente, Ángela, Llop, Elba, Simón-Talero, Macarena, Álvarez-Navascués, Carmen, Reiberger, Thomas, Verhelst, Xavier, Tellez, Luis, Bergmann, Johanna Birte, Orts, Lara, Grassi, Giuseppe, Baiges, Anna, Audrey, Payance, Trebicka, Jonel, Villanueva, Candid, Morelli, Maria Cristina, Murray, Sam, Meacham, Georgina, Luetgehetmann, Marc, Schulze zur Wiesch, Julian, García-Pagán, Juan-Carlos, Barnes, Eleanor, Plessier, Aurélie, and Hernandez-Gea, Virginia

Published
2024
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16. Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis

Author

Judit Vidal-González, Javier Martínez, Akhilesh Mulay, Marta López, Anna Baiges, Ahmed Elmahdy, Katharina Lampichler, Geert Maleux, Johannes Chang, Marta Poncela, Gavin Low, Gabriele Ghigliazza, Alexander Zipprich, Carmen Picón, Rushabh Shah, Elba Llop, Anna Darnell, Martin H. Maurer, Lawrence Bonne, Enrique Ramón, Sergi Quiroga, Juan G. Abraldes, Aleksander Krag, Jonel Trebicka, Cristina Ripoll, Vincenzo La Mura, Puneeta Tandon, Rita García-Martínez, Michael Praktiknjo, Wim Laleman, Thomas Reiberger, Annalisa Berzigotti, Virginia Hernández-Gea, José Luis Calleja, Emmanuel A. Tsochatzis, Agustín Albillos, Macarena Simón-Talero, and Joan Genescà

Subjects
Collateral vessels, Portal hypertension, Advanced chronic liver disease, Computed tomography, Magnetic resonance imaging, Hepatitis C virus, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Spontaneous portosystemic shunts (SPSS) develop frequently in cirrhosis. Changes over time and the effect of aetiological interventions on SPSS are unknown, so we aimed to explore the effect of these variables on SPSS evolution. Methods: Patients with cirrhosis from the Baveno VI-SPSS cohort were selected provided a follow-up abdominal CT or MRI scan was available. Clinical and laboratory data were collected at baseline and follow-up. Imaging tests were reviewed to evaluate changes in the presence and size of SPSS (large (L)-SPSS was ≥8 mm) over time. Regarding alcohol- or HCV-related cirrhosis, two populations were defined: cured patients (abstinent from alcohol or successful HCV therapy), and non-cured patients. Results: A total of 617 patients were included. At baseline SPSS distribution was 22% L-SPSS, 30% small (S)-SPSS, and 48% without (W)-SPSS. During follow-up (median follow-up of 63 months), SPSS distribution worsened: L-SPSS 26%, S-SPSS 32%, and W-SPSS 42% (p

Published
2024
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17. Del territorio al asentamiento y del asentamiento al territorio: la investigación arqueológica en áreas de montaña y alta montaña en el Pirineo central

Author

Ermengol Gassiot Ballbè, Guillem Salvador Baiges, Laura Obea Gómez, Sara Díaz Bonilla, David Garcia Casas, David Rodríguez Antón, Ignacio Clemente Conte, and Niccolò Mazzucco

Subjects
arqueología espacial, arqueología del paisaje, arqueología de la alta montaña, Pirineos, Mesolítico, Neolítico, Archaeology, CC1-960
Abstract

Aunque reciente en nuestra disciplina, la arqueología de las zonas de alta montaña poco a poco va consolidándose, generando corpus empíricos y procedimientos que en muchas ocasiones constituyen sus señas de identidad. Por encima de la diversidad de equipos y programas de investigación, algunos aspectos tienden a presentarse de forma recurrente. Uno es un cierto interés por las secuencias de larga duración. Otro lo constituye la mirada hacia un espacio amplio, que va mucho más allá del asentamiento. Este interés por el territorio o el paisaje, que en ocasiones se prefigura como un verdadero objeto de estudio, conlleva cambios en el diseño metodológico de la investigación. En este trabajo pretendemos recoger los ya casi veinte años de experiencia del Grupo de Arqueología de la Alta Montaña (GAAM) de la UAB y el CSIC para presentar una breve reflexión teórica sobre un aspecto que, a nuestro entender, es central en nuestra disciplina. La arqueología, en cuanto ciencia social, aborda una existencia humana colectiva que ocurre tanto en el tiempo como en el espacio. Por diversos motivos, la arqueología en áreas de alta montaña ha sido especialmente proclive a incorporar elementos metodológicos para tratar con el espacio también como instancia social. Quizás ha llegado el momento de empezar a evaluar los puntos fuertes de estas propuestas y tratar de identificar aquellas cuestiones que merecen mayor atención. En la parte final del artículo ilustramos, con un caso empírico, la pertinencia de la reflexión teórica planteada.

Published
2023
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22. Splanchnic vein thrombosis associated with SARS-CoV-2 infection: A VALDIG case–control study

Author

Pierre Deltenre, Audrey Payancé, Laure Elkrief, Vincenzo La Mura, Florent Artru, Anna Baiges, Jean-Paul Cervoni, Louise China, Isabelle Colle, Elise Lemaitre, Bogdan Procopet, Dietmar Schiller, Christophe Bureau, Odile Goria, Isabelle Ollivier, Alexandre Nuzzo, Pierre-Emmanuel Rautou, and Aurélie Plessier

Subjects
Splanchnic vein thrombosis, Portal vein thrombosis, SARS-CoV-2 infection, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a risk factor for splanchnic vein thrombosis (SVT) is unknown. This study aims to assess the impact of SARS-CoV-2 infection on the presentation and prognosis of recent SVT and to identify specific characteristics of SARS-CoV-2-associated SVT. Methods: This is a retrospective study collecting health-related data of 27 patients presenting with recent SVT in the context of SARS-CoV-2 infection in 12 Vascular Liver Disease Group (VALDIG) centres and in comparison with 494 patients with recent SVT before the SARS-CoV-2 pandemic. Results: Twenty-one patients with SARS-CoV-2 had portal vein thrombosis with or without thrombosis of another splanchnic vein, two had superior mesenteric vein thrombosis, one had splenic vein thrombosis, and three had hepatic vein thrombosis. Diagnosis of SVT was made 10 days (95% CI 0–24 days) after the diagnosis of SARS-CoV-2 infection. Fever (52 vs. 15%; p

Published
2023
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27. Impact of SARS-CoV-2 Pandemic on Vascular Liver Diseases

Author

Baiges, Anna, Cerda, Eira, Amicone, Caroline, Téllez, Luis, Alvarado-Tapias, Edilmar, Puente, Angela, Fortea, Jose Ignacio, Llop, Elba, Rocha, Filipa, Orts, Lara, Ros-Fargas, Oliva, Vizcarra, Pamela, Zekrini, Kamal, Lounes, Ould Amara, Touati, Ghiles, Jiménez-Esquivel, Natalia, Serrano, Maria Jose, Falgà, Angels, Magaz, Marta, Olivas, Pol, Betancourt, Fabian, Perez-Campuzano, Valeria, Turon, Fanny, Payancé, Audrey, Goria, Odile, Rautou, Pierre-Emmanuel, Hernández-Gea, Virginia, Villanueva, Candid, Albillos, Agustin, Plessier, Aurélie, and García-Pagán, Juan-Carlos

Published
2022
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28. Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Author

Mateo, Francesca, He, Zhengcheng, Mei, Lin, de Garibay, Gorka Ruiz, Herranz, Carmen, García, Nadia, Lorentzian, Amanda, Baiges, Alexandra, Blommaert, Eline, Gómez, Antonio, Mirallas, Oriol, Garrido-Utrilla, Anna, Palomero, Luis, Espín, Roderic, Extremera, Ana I., Soler-Monsó, M. Teresa, Petit, Anna, Li, Rong, Brunet, Joan, Chen, Ke, Tan, Susanna, Eaves, Connie J., McCloskey, Curtis, Hakem, Razq, Khokha, Rama, Lange, Philipp F., Lázaro, Conxi, Maxwell, Christopher A., and Pujana, Miquel Angel

Published
2022
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29. Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Author

Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I. Extremera, M. Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J. Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F. Lange, Conxi Lázaro, Christopher A. Maxwell, and Miquel Angel Pujana

Subjects
Science
Abstract

The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune permissive environment for breast cancer development.

Published
2022
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30. Degenerative joint disease (DJD) in non-human primates and its relationship to locomotor adaptation and support use

Author

Baiges Sotos, Laura, Nystrom, Pia, and Kuykendall, Kevin

Subjects
930
Abstract

This thesis examines degenerative joint disease (DJD) in non-human primates with the aim to detect potentially contributing factors to its presence. Locomotor behaviour has received little attention in studies on DJD in non-human primates as a potential causal factor, despite the great locomotor diversity of the order and the link between human bipedalism and DJD. The main goal was to explore the relationship between the disease and the stress exerted on joints, mainly as a result of locomotion. Locomotor adaptation and locomotor strategy were considered alongside with non-locomotor factors (principally body mass and age) as causal factors for joint degeneration. DJD was recorded for the main weight-bearing joints of 35 taxa of non-human primates, representing a wide variety of locomotor adaptations (vertical clingers and leapers, slow arboreal quadrupeds, leapers, quadrupeds, knuckle-walkers and suspensory primates). These taxa move according to different locomotor strategies, such as different speeds (fast and slow moving species) or different patterns of habitat use (arboreal, terrestrial or semi-arboreal species), which led to interactions with supports of different levels of compliance. The primate taxa studied showed different patterns of DJD expression, which were partially determined by locomotor behaviour. Primates of different locomotor adaptations showed different distribution patterns of DJD according to the levels of stress exerted on different joints or body compartments as a result of locomotion. Moreover, the adoption of different locomotor strategies was coupled with variability of DJD. Other factors, such as body mass or age showed significant correlations with DJD severity exhibiting different coefficients at different joints and body compartments, suggesting that their effect on DJD expression was likely to be important but only in combination with other factors. Multivariate analyses confirmed this conclusion, demonstrating the important effect of mechanical factors in variability of the early development of DJD, as well as a consistent effect of age, especially correlated with an increase in DJD severity and variability. DJD in non-human primates is clearly a multifactorial phenomenon, where stress related to locomotion plays an important role. A new perspective in the study of DJD was presented, providing a good basis for future studies from which other areas could benefit, such as sports medicine, evolutionary primatology or captive care studies.

Published
2018

34. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author

García-Tornel, Álvaro, Flores, Alan, Terceño, Mikel, Cardona, Pedro, Amaro, Sergi, Gomis, Meritxell, Zaragoza, Josep, Krupinski, Jerzy, Gómez-Choco, Manuel, Mas, Natalia, Cocho, Dolores, Catena, Esther, Purroy, Francesc, Deck, Matias, Rubiera, Marta, Pagola, Jorge, Rodriguez-Luna, David, Juega, Jesús, Rodríguez-Villatoro, Noelia, Molina, Carlos A., Soro, Cristina, Jimenez, Xavier, Salvat-Plana, Mercè, Dávalos, Antoni, Jovin, Tudor G, Abilleira, Sonia, Pérez de la Ossa, Natalia, Ribó, Marc, Sanjuan, Estela, Santana, Katherine, Maisterra, Olga, Santamarina, Estevo, Muchada, Marian, Boned, Sandra, Franco, Antonio Palasi, Gadea, Marta Olivé, Deck, Matías, Requena, Manuel, Sala, Victoria, Muñoz, Lucía, Millán, Mónica, López-Cancio, Elena, Dorado, Laura, Hernández-Pérez, María, Ciurans, Jordi, Samaniego, Daniela, Canento, Tamara, Martin, Lorena, Planas, Anna, Broto, Joaquin, Sorrentino, Agustín, Paré, Martí, Zhu, Nuole, Garrido, Alicia, Grau, Laia, Crespo, Ane Miren, Presas, Silvia, Almendrote, Miriam, Ramos, Alba, Lucente, Giuseppe, Ispierto, Lourdes, Lozano, Manuel, Becerra, Juan Luis, Jiménez, Marta, Rolán, Dolores Vilas, Guanyabens, Nicolas, Sanchez-Ojanguren, Josep, Martínez-Piñeiro, Alicia, Forcén, Sara, Gea, Mireia, Álvarez, Marta, Ramos, Anna, Lizarbe, Manuel Domínguez, Guerra, Rubio, Bragado, Irene, Arbex, Andrea, Rodríguez, Luis, Bustamante, Alejandro, Portela, Pere Cardona, García, Helena Quesada, Rodríguez, Blanca Lara, Cayuela, Nuria, Miró, Julia, Marzal, Clara, Paipa, Andrés, Campoy, Sergio, Núñez, Ana, Arroyo, Pablo, Besora, Sarah, Adell, Vanessa, Campdelacreu, Jaume, Martí, Montse Alemany, González, Belén, Vila, Laura Bau, Crespo, Marta Fiter, Berbel, Anna, Urbaneja, Ma. Cristina Villaescusa, Guillen, Núria, Vidal, Nuria, Santamaria, Patricia Valentina Vérez, Navarro, Diego Herrero, Simó, Marta, Falip, Mercedes, Matas, Elisabeth, Ochoa, Neus Mongay, Gifreu, Ariadna, Muñoz, Albert, Romero, Lucía, Portell, Eduard, Perez, Guillermo Hernández, Esteve, F. Ruiz, Teixidor, Silvia, Talavera, Augusto Salazar, Gómez, Roser, Nuin, Xabier Urra, Vargas, Martha, Chamorro, Ángel, Llull, Laura, Renú, Arturo, Rudilosso, Salvatore, del Valle, Raquel Sánchez, Ariño, Helena, Solà, Nuria, la Puma, Delón, Gil, Francisco, Gómez, Juan Bernardo, Matos, Nuria, Falgàs, Neus, Borrego, Sergi, Sánchez, Almudena, Balasa, Mircea, Montejo, Carmen, Guasp, Mar, Reyes, David, Cervilla, Pablo Sánchez, Contador, Jose Miguel, Monge, Victor Augusto Vera, Ramos, Oscar, Rodríguez, Alejandro, Campello, Ana Rodríguez, Ballester, Gemma Romeral, Trujillano, Mireia Llop, Steinhauer, Eva Giralt, Godia, Elisa Cuadrado, Santiago, Angel Javier Ois, Conde, Jordi Jimenez, Fábregas, Joan Martí, Guisado, Daniel, Prats, Luís, Camps, Pol, Delgado, Raquel, Domeño, Alejandro Martínez, Marín, Rebeca, Cànovas, David, Estela, Jordi, Ros, Marta, Aranceta, Sonsoles, Espinosa, Jordi, Rubio, Marta, Lafuente, Cristina, Barrachina, Oriol, Anguita, Alicia, Reverter, Anna, García, Carmen, Sansa, Gemma, Hervas, Mariona, Crosas, Monica, Delgado, Tania, Folch, Dra Sonia Huertas, Gamito, Gemma Muñoz, Alvarez, Josep Trenado, Subirana, Teresa, Molina, Jessica, Besora, Sarah, Romero, Laura Comes, Valls, Gemma Guardia, Jover, Miriam, Sotova, Javier Joaquín, García Sánchez, Sonia Mª, Valenzuela, Sebastian, Mengual, Juan José, Font, M. Àngels, Gómez Ruiz, Mª Isabel, Zubizarreta, Irati, González, Susana Fernández, Gubieras, Laura, Cobos, Carmen E., Romo, Luis Mena, Caballol, Nuria, Cano, Luis, Leal, Joaquín Serena, Blas, Yolanda Silva, Trigo, Irene Bragado, Viturro, Saima Bashir, Albiñana, Laura Pardo, Garrido, Montserrat Reina, Cazcarra, Carla Marco, Uscamaita, Karol Enrique, Márquez, Fabian, Coll, Cristina, Villlas, Mar Irida Lloret, Vila, Berta Solano, Perna, Berta Alemany, Domínguezl, Daniel López, de Lera, Mercedes, Foraster, Anna Cots, Monge, Victor Augusto Vera, Bojaryn, Urszula, Benabdelhak, Ikram, Capdevila, Gerard Mauri, Montesinos, Jordi Sanahuja, Vázquez, Daniel, Hervás, José Vicente, González, Cristina, Quílez, Alejandro, Pascual, Mikel Vicente, Ruiz, María, Riba, Yolanda, Villar, M. Pilar Gil, García, Cristina, Roig, Xavier Ustrell, Mora, Mònica Baldrich, Guinjoan, Anna Pellisé, Borras, Judit, Martínez, Alba Mañé, Marés, Rafael, Viñas i Gaya, Jaume, Seró, Laia, Rodríguez, Paula, Castilho, Gislaine, Ortega, Angela Monterde, Reverté, Silvia, Baiges, Joan Josep, Ozaeta, Gisela Martín, Escalante, Sonia, Belloch, Patricia Esteve, Payo, Iago, Salvado, Júlia Saura, Soler Insa, Josep M, Vilamala, Ester Tio, Navarro, Josep Abos, Tabuenca, Héctor Cruz, Sánchez, Tamara Canento, Ros, Marta, Matos, Nuria, Roldán, Elisabet, Rubiol, Elsa Puiggrós, Franquet, Elisabet, Fuentes, Lidia, Donaire, Javier, Martí, Elena, Giménez, Laura, Vázquez, Junior Gil, Ambrós, Eloisa Nieto Clara Gris, Rodríguez, Puri, Oletta, José Félix, Mellado, Pilar Pons, Gómez, Bárbara, Raileau, Vergilin, Pardina, Oscar, Mercadal, Jordi, López-Diéguez, María, Pérez, Pilar, Gabarró, Lourdes, Orriols, María, Molina, José Carlos, Canet, Joan Josep, Roca, Mireia, Álvaro, Muriel, Boneu, Francesc, Giménez, Georgina, Albà, Jaume, Gibert, Francesc, Garcia, Jéssica, Barragan, Patricia, Jurado, Gustavo, Pascual_Medicina Interna, Vanesa, Ortega, Josep Sabaté, Solano, Joan Amaurys Martínez, Fernández, Víctor, Torres, Mónica, Alvaredo, Ana Belén Montero, Parejo, Laura Redondo, Aragonés, Josep Maria, Bullón, Anna, Loste, Cora, González, Paula, Bejarano, Neker, Sanchez, Francisco, Lucchetti, Gianni, Pla, Xavier, Gimeno, Dr Javier, Reynaga, Esteban, Barcons, Montse, Celedón, Gabriel, Ortiz, Juan, Anastasovski, Dr Goran, Mascaró, Dr Oscar, de los Ríos, Dr Javier Diez, Feliu, Meritxell, Ribera, Anna, Ruiz, Cristhian, Corominas, Gerard, Nunes, Dra Daniella, Roca, Claudia, Latorre, Nadina, Yataco, Lizbeth, Cruz, Maricelys, Blanco, Nerea, Castejón, Santiago, Sunyer, Claustre Pont, Garcia, Jordi Espinosa, Martin, Rodrigo Paz, de Luis Sanchez, Albert, Vivas, Dolores Espinosa, Molina, Juan Valencia, Palome, Planels, Chaume, Laia Tomas, Vilella, Ares Villagrasa, Bustamante, Marco, Boltes, Anunciación, Rodríguez, Fernando, Arrieta, Itziar, Molist, Jordi Ciurans, Andreu, Barnés, Soler, Ernest Palomeras, Buscà, Nicolau Guanyabens, López, Manuel Daza, Farreres, Jordi Bigas, Ruiz, Virginia Casado, Batiste, Desiree Muriana, Sanz Cartagena, Mª Pilar, de Vega, Eulalia Cabot, Real, Josep Bassa, Roman, Hector Pelaez, Socolich, César, Alonso Camp, Josep Mª, Orgaz, Antonio Tomás Cano, Fossas Felip, Mª Pilar, Morón, Nicolás, Bacca, Sandra, Molina, Mauricio, Casarramona, Francesc, Elias, Lorena, Bukaei, Muhammad Zidane, Gutierrez, Jose Antonio Martos, Escuin, Judith Lopez, Olaizola, Cristina, Vargas, Yolexis López, Oyonarte, Juan Jiménez, Soultana, Rashida, Golpe, Eduardo Sanjurjo, Salvador, Esther, Vila, Guillem, Serrano, Marcos, Claverol, Matilde Nuria López, Lamolla, Marian, Amate, Miquel, Rodriguez, Adriana, Romero, Ruth, del Carpio, Montgomery, Hernandez, Ana Isabel, Martín, Julián, Rosas, M Carmen, Nogueroles, Antonio, Encarnación, Sorilandy, Robles, Augusto, Herrera, Jose Antonio, Gavilán, Roger, Mameghani, Toghrol, Araujo, Gastón, Morales, M.Angeles Garrido, Segui, Enric Ramon Albert, Climent, Eva Fernandez, Pujol, Francesc Paris, Seira, Mireia Judit Garrofé, Pía, Lucía Gómez, Nuñez, Fernando Salleres, Peñalver, Cristina Aguar, Lopes, Cristina Vaz, Tasa, Elisenda Ribera, Vilchez, Carmen Repullo, Zambrana, Modesto Sánchez, Ribas, Beatriu Suescun, Panés, Inés Vilà, Planavila, Montserrat Vila, Lorenzo, Alicia Vaqueiro, Guixes, Meritxell Sabartés, Medina, Jorge, Sambrano, David, Zamarreño, Javi, Pirela, Carmen, Vélez, Paola, Cajamarca, Luis, Pérez, Honey, Martínez, Yarles, Gonçalves, Jesus Alexander, Regordosa, Carles, Mormeneo, Claudia, Griu, Laura, Colina, Maria Francia, Farik, Enric, Duch, Dolors Carrión, Badenas, Carles, Bernal, Oscar, Agramunt, Núria, Morales, Shyrlei, Reynoso, Victoria, Guerrero, Miguel, Cid, Primitivo Romera, Folqué, Mònica, Pedroza, Claudia, Hachem, Adnan, Martínez, Íñigo Soteras, García, Xavier Verdera, Amorós, Mercè López, Subirós, Xavier Costa, Benet, Marta Cufí, Van Eendenburg, Cecile, Osuna, Teresa, Santos, Dra Gina, Pallisera, Dra Mireia, Oliva, Dr Lluís Gonzalo, Sanchez, Dra Gemma, Basurto, Dr Xavier, Vivoda, Dr Ludgi, Van der Kleyn, Dr Richard, Robles, Dra Laura, Barranco, Ana Cabanelas, Almendros, Mª Cruz, Oliveras, Marc Pérez, Álvarez, Amelia Fernández, Rybyeva, Maria, Viñas, Antoni, Barcons, Maria, Tavera, Joaquim Danès Alberto, Burbano, Pablo, López, Cintie, Cruz, David, Bisbe, Paula, Fernández, Nora, Palacio, Juan Carlos, Fraiz, Eduardo, Aguiló, Oriol, Amorodjo, Rollmy, Velázquez, John, Sánchez, Elena, Español, Jaume, Perez de Celis, Judit, Coll, Anna, Díaz, Glòria, Vergés i Sala, Margarida, Casas Capdevila, Mª Ángels, Ferrini, Yosmairy Yoselin, Gorriz, Aitor, Navarro, Diego-Javier Cucurell, Velásquez, Dulce, Pla Soler, Jaume, González, Josep, Higuera, Julian David, Cuellar, Lina, Miniello, Liza Margarita, Pujol, Lluis, Cracan, Sorin, Vives, Mora, Angela, M, Lopez, Lopez, Molist, Montse Gorchs, Anna, Delofeu, Muñoz, Silvia Solà, Yolanda, Ferreres, Pujalte, Carol, Marín, Elisabeth Téllez, Casas, Yolanda Font, Luque, Sara Hernández, Sendra, Joaquim Mejias, Valero, Francesca Mellado, Escala, Campos, De Lacanal, Galup, Diaz, Lopez, Paramio, Castillo, Estopà, Català, Moreda, Español, Majo, Calafell, Almeida, Carballo, Naval, Castro, Elena, M, Ruiz, Cregut, Lluis, Pere, Font, Deulofeu, Sanjuan, Fabregat, Pere, Joan, Gorchs, Fontquerni, Bellés, Forés, Antoni, Joan, Herrera, Gomez, Carlos, Juan, Prades, Hijazo, Torvisco, Itzaina, Rovira, Marti, Gonzalez, Obiols, Cavero, Olive, Gil, Querol, Soledad, M, Rodriguez, Rico, Sambernardo, Rios, Molina, Ropero, Ramon, Jose, Valero, Sanchez, Arevalo, Santos, Jose, Maria, Garcia, Soto, Angeles, Maria, Escribano, Tebar, Garcia, Torres, José, Pedro, Carrion, Verdes, Isabel, M, Lopez, Verge, Jose, Juan, Canela, Lopez, Angeles, M, Guarque, Lucas, Alvarez, Morales, Arnulfo, Jorge, Fornieles, Morell, Gomez, Subirats, Teresa, Maria, Masa, Miquel, Torello, Lopez, Val, Mercedes, Maria, Reyes, Palmero, Manuel, Juan, Forne, Rodriguez, Turiel, Ruana, Gonzalez, Sanchez, Gornals, Sebastia, Rico, Abrio, Falip, Albert Gual, Oliveros, Aznar, Perotti, Brugues, Molinero, Calvet, Franco, Catells, Medina, Corrales, Miro, Daroca, Marquez, Duran, Pradas, Feliu, Casanova, Figueras, Tortajada, Garcia, Gallego, Grajera, del Mar, Azahara, Arroyo, Las, de Jesus, Dulcenombre, Sanz, Laserreta, Vidal, Llambrich, Corral, Monllao, de la Cruz, Morales, Blanco, Moreno, Orgaz, Orejuela, Suazo, Piñana, Minguillon, Pons, Gómez, Rodríguez, Carlos, José, Pereira, Rodriguez, Porcel, Anna, Sedo, Villar, Sevil, Lopez, Sierra, Romero, Torres, Calveres, Anna, Trepat, Arnella, Ventura, Gil, Acera, Teresa, M, Vico, Biesot, Galea, Castro, Maria, Rosa, Chafer, Escorcia, Antonio, Juan, Moreda, Español, Faure, Gil, Luque, Hernandez, Delgado, Jimenez, Gay, Mallafre, Angel, M., Sanzo, Olivares, Fondevila, Pubill, Fort, Sabate, Agámez, Segovia, Carlos, Antonio, Longaretti, Turata, Hernandez, Valle, Guixens, Trayner, Valor, Aguilar, Alvarez, Aguirre, Naval, Alastrue, Baquero, Alferez, Marne, Alonso, Orozco, Aloy, Colino, Alvarez, Peñuela, Alvarez, Cirilo, Ameller, Vanessa, Maria, Guerrero, Andujar, Remedios, Estefania, Sillero, Auladell, Sorbet, Azcarate, Genesca, Basany, Barduena, Benavent, Tudela, Benito, Pardo, Blanch, Pla, Boluda, Gonzalez, Bonilla, Serramalera, Bru, Andreu, Burnat, Calvo-Rayo, Caballero, Casellas, Calvo, Mombiela, Camps, Bresme, Cano, Fernandez, Carcelen, Solà, Caro, Matavacas, Casasas, Bolado, Castanedo, Cortina, Cerdeña, Jane, Abella, Borrego, Laia Collado, Orri, Colom, Vilanova, Comellas, Sole, Conillera, Torres, Cots, Estepa, Cuchi, de Sostoa Graell, Marc, del Rio Lopez, Laura, Compte, Delgado, Bueno, Diaz, Maneiro, Diaz, Lucia, Andrea, Palau, Domenech, Carme, M., Carasso, Duran, Javier, Pablo, Marquez, Duran, Abidi, El, Martin, Escoda, Casanovas, Esteve, Perez, Fernandez, Quintero, Ferre, Escobar, Flores, Abad, Fontcuberta, del Valle, Fortes, del Valle, Fortes, Luisa, Mª, Quesada, Franco, Maria, Sara, Romero, Franco, Teresa, Maria, Francisco, Gallego, Gala, Gamiz, Castañeda, Garcia, Rodriguez, Garcia, Gemma, Casajuana, Arroyo, Gomez, Girbau, Gomez, Fernandez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Lopez, Gonzalez, Obeso, Gual, Blanco, Guerrero, Roca, Guillemas, Eudaldo, Guillermo, Hernandez, Sebastia, Covas, Homar, Alvarez, Hostench, Royo, Huerta, Barcelo, Ibañez, Cruz, Izquiero, Etxetxikia, Jaione Urdangarin, Gimenez, Juárez, Alami, Khlifi, Gasco, Laparra, Moreales, Lara, Arroyo, Las, de Jesus, Dulcenombre, Medina, Lasaosa, Lourdes, Maria, Cava, Lazaro, Berrar, Leon, Maturana, López, Ramirez, Lopez, Romero, López, Marco, Lorente, Martin, Lorenzo, Casals, Lozano, Nicola, Lujan, Diaz, Madrid, Antonio, Jose, Morales, Maria Teresa Peris, Clemente, Marti, Castaño, Martinez, Natanael, David, Gamez, Martinez, Gonzalez, Martinez, Quesada, Martinez, de la Cabeza, Maria, Fusté, Marzà, Lasheras, Melendo, Mestre, Miralles, Pastalle, Montserrat Puig, Vidal, Montserrate, Mellado, Mora, Ponce, Morales, Fornieles, Morell, Cabre, Morera, Vivet, Morera, Souza, Mundi, Quiles, Muñoz, Rosa, Navea, Iglesias, Neira, Asuncion, M, Manrique, Nuñez, Pilar, Mª, Martinez, Obiols, Reig, Pallares, Torres, Partegas, Berengueras, Pascual, Gamez, Perez, Oset, Perez, Restrepo, Perez, Alejandra, Maria, Yeste, Planas, Mangado, Planells, Minguillon, Pons, Carbonell, Puertas, Blanco, Quinteiro, Benavente, Rebollar, Fernandez, Recasens, Gomez, Reyes, del Carmen, Maria, Pou, Roca, Ferrer, Rodriguez, Franco, Rodriguez, Fuertes, Rodriguez, Muñoz, Rodriguez, Navarro, Rodriguez, Iniesta, Roig, Gracia, Romero, Brunet, Rovira, de Eugenio, Rovira, Baena, Rubio, Llorens, Ruiz, Llamazares, Sala, Alaez, San Juan, Segura, Sanchez, Soldevilla, Santasusana, Salmeron, Sanz, Perez, Segura, Balcells, Serra, Dumitras, Sorina, Montoya, Teixidor, Vicente, Tena, Salinas, Tierno, Ines, Ester, Testa, Toledo, Figueras, Tomàs, Ruperez, Tomas, Garcia-Penche, Torrano, Esparza, Torres, Blanco, Vazquez, De la Paz, Vazquez, Gil, Vazquez, Gonzalez, Vazquez, Meler, Vidal, Cots, Vilalta, Jimenez, Vilches, Jose, Maria, Fernandez, Visser, Gavin, Viu, Vives, Vives, Jimenez, Carmona, Jose, Francisco, Vilches, Galobardes, Gomez, Gonzalez, Manzanera, Jodar, Cortes, Marimon, Orive, Marrodan, Bosch, Martin, Jose, Maria, Lopez, Martorell, Roca, Millares, Jesus, M, Guri, Miralles, Hernandez, Muliterno, Oliva, Muñoz, Pujol, Pons, Conde, Postius, Arruñada, Prieto, Antonio, Jose, Mathé, Quintana, Mata, Rosell, Alvarez, Aguirre, Alvarez, Alvarin, Flores, Arrufat, Pago, Bañuelos, Andreu, Burnat, Vilar, Campo, Hidalgo, Cardus, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Estopà, Català, Garces, Clave, Sanroma, Comes, Sequi, Descalzo, Ricol, Errando, Campillo, Escudero, del Mar, Maria, Alvarez, Fernandez, Gomez, Fernandez, Perez, Fernandez, Espinosa, Franch, Graells, Freixes, Plaza, Garcia, Gallego, Garcia-Marron, Simancas, Hernandez, Covas, Homar, Royo, Huerta, Armas, Jaraba, Ramos, Jimenez, Canela, Lopez, Angeles, M, Lopez, Lopez, Oganissian, Lopez, Romero, Madrona, Rosa, M, Millan, Martinez, Morón, Martínez, Encinas, Merchan, Fornieles, Morell, Jimenez, Moreno, Rico, Muñoz, Rodriguez, Navarro, Ibañez, Nogales, Maria, Rita, Viera, Novillo, Torrabadella, Parella, Alba, Mari, Villar, Pera, Montserrat, Carla, Carbonell, Puertas, Miralles, Rabella, Trilles, Ramis, Ortiz, Ribera, Fuertes, Rodriguez, Gonzalez, Sanchez, Perez, Sastre, Perez, Segura, Borrega, Soro, Garcia, Soto, Angeles, Maria, Fores, Tapia, Bernad, Tellez, Alvarez, Trenado, Moreda, Español, Martin, Felix, Perez, Herrero, Manzanera, Jodar, Fuster, Lanau, Gomariz, Lopez, Orive, Marrodan, Bosch, Martin, Jose, Maria, Guri, Miralles, Oliva, Muñoz, Lozano, Pardo, Pujol, Pons, Altimiras, Quintana, Lopez, Ventosa, Damian, Almodovar, Colino, Alvarez, Monterroso, Alvarez, Comas, Arambudo, Garzon, Boullon, Capella, Burgos, Garcia, Campuzano, Del Mar, Maria, Olivas, Capdevila, Fernandez, Carcelen, Solà, Caro, Marti, Carre, Isabel, Clara, Bacaicoa, Carretero, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Calderon, Cazorla, Osuna, Chacon, Planas, Cortes, Olio, Cortit, Estany, Delhomme, Carasso, Duran, Javier, Pablo, Campillo, Escudero, del Mar, Maria, Martinez, Fructuos, Lopez, Garcia, Luis, Pascual, Plaza, Garcia, Vallve, Genis Amill, Arroyo, Gomez, Girbau, Gomez, Muñoz, Gonzalez, Ventura, Hernaez, Covas, Homar, Gimenez, Lavernia, Rojo, Martin, Medina, Martínez, Millan, Martinez, Barrera, Mayol, Pi, Mercader, Dalmau, Merino, Campodarbe, Miguel, Pastalle, Montserrat Puig, de la Cruz, Morales, Fornieles, Morell, Sanchez, Moreno, Javier, Francisco, Reig, Pallares, Torrabadella, Parella, Alba, Mari, Barrameda, Penela, Ajenjo, Prieto, Benavente, Rebollar, Pareja, Rodriguez, Piñar, Rodríguez, Javier, Francisco, Tello, Rodriguez, Pereda, Romero, Saborido, Sainz, Martin, Santacana, Martinez, Santos, Chavez, Sierra, Testa, Toledo, Figueras, Tomàs, Garcia, Torres, José, Pedro, Torres, Turbau, Domenech, Vicente, Esteo, Villena, Pertegaz, Vives, Gonzalez, Baena, Pont, Bagaria, Sanchez, Beltran, Alarcon, Bonet, Ballescà, Borch, Clanchet, Buhils, Garcia, Closa, Carril, Colomina, Sanchez, Cristina Fernandez, Toledo, Edurne Judith Fernandez, Rodriguez, Espases, Resa, Espert, Xavier, F, Sol, Fernández, Lugo, Gonzalez, Llesera, Gracia, Lendinez, Herrada, Liesa, Juliench, Alicia, Sandra, Ortega, Lopez, Yuste, Lopez, Villanueva, Lozano, Soto, Lucia Sola, Castellano, Madrid, Cano, Megias, Jesus, Daniel, Ponce, Montasell, Sospedra, Montesinos, Martinez, Moya, Herrera, Muñoz, Isabel, M, Fernandez, Ocaña, Jose, Maria, Bernal, Palau, Sole, Perez, Carbonell, Ramon, Lop, Ribas, López, Rubio, Lopez, Rueda, Castaño, Sabat, Lara, Sabata, Ramírez, Salmerón, Gornals, Sebastia, Creus, Serra, Dalmau, Serrano, Mainero, Sumasi, Gabriel, Gonzalo, Masa, Torello, Primo, Valencia, Muñoz, Ana Maria Viñuales, Roig, Josep, and Hidalgo, Verònica

Published
2023
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35. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry

Author

Salvatore Rudilosso, José Ríos, Alejandro Rodríguez, Meritxell Gomis, Víctor Vera, Manuel Gómez-Choco, Arturo Renú, Núria Matos, Laura Llull, Francisco Purroy, Sergio Amaro, Mikel Terceño, Víctor Obach, Joaquim Serena, Joan Martí-Fàbregas, Pedro Cardona, Carlos Molina, Ana Rodríguez-Campello, David Cánovas, Jerzy Krupinski, Xavier Ustrell, Ferran Torres, Luis San Román, Mercè Salvat-Plana, Francesc Xavier Jiménez-Fàbrega, Ernest Palomeras, Esther Catena, Carla Colom, Dolores Cocho, Juanjo Baiges, Josep Maria Aragones, Gloria Diaz, Xavier Costa, María Cruz Almendros, Maria Rybyeba, Miquel Barceló, Dolors Carrión, Matilde Núria Lòpez, Eduard Sanjurjo, Natalia Pérez de la Ossa, Xabier Urra, Ángel Chamorro, and for the Catalan Stroke Code and Reperfusion (Cat-SCR) Consortium

Subjects
thrombectomy, stroke, prognosis, outcome, registries, propensity score, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score 3), good (if NIHSS

Published
2021
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36. Mountains, Herds and Crops: Notes on New Evidence from the Early Neolithic in the Southern Central Pyrenees

Author

Gassiot-Ballbè Ermengol, Mazzucco Niccolò, Díaz-Bonilla Sara, Obea-Gómez Laura, Rey-Lanaspa Javier, Barba-Pérez Marcos, Garcia-Casas David, Rodríguez-Antón David, Salvador-Baiges Guillem, Majó-Ortín Tona, and Clemente-Conte Ignacio

Subjects
early neolithic, mesolithic, pyrenees, agriculture, livestock, Archaeology, CC1-960
Abstract

After years of intense fieldwork, our knowledge about the Neolithisation of the Pyrenees has considerably increased. In the southern central Pyrenees, some previously unknown Neolithic sites have been discovered at subalpine and alpine altitudes (1,000–1,500 m a.s.l.). One of them is Cueva Lóbrica, 1,170 m a.s.l., which has an occupation phase with impressed pottery dated ca. 5400 cal BCE. Another is Coro Trasito, 1,558 m a.s.l., a large rock shelter that preserves evidence of continuous occupations in the Early Neolithic, 5300–4600 cal BCE. Evidence of human occupation at higher altitudes has also been documented. In the Axial Pyrenees, at the Obagues de Ratera rock shelter, 2,345 m a.s.l., an occupation has been dated to around 5730–5600 cal BCE. At Cova del Sardo, in the Sant Nicolau Valley, at 1,780 m a.s.l., a series of occupations have been excavated, dated to ca. 5600–4500 cal BCE. These sites allow us to discuss patterns of occupation of the mountainous areas between the Late Mesolithic and Early Neolithic. Recent data suggest that the last hunter–gatherer occupied all altitudinal stages of the Pyrenees, both in the outer and inner ranges. A change in the settlement pattern seems to have occurred in the Early Neolithic, which consisted of a concentration of occupations in the valley bottom and mid-slopes, in biotopes favourable to both herding and agriculture.

Published
2021
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38. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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39. Perspectivas metodológicas docentes en estudios de posgrado de historia y antropología de América

Author

Ruz Barrio, Miguel Ángel, Batalla Rosado, Juan José, Bordón Ojeda, Marisa Leonor, Díaz Baiges, David, Gil García, Francisco Miguel, Luque Talaván, Miguel, Moreno Amador, Carlos, Muñoz Morán, Óscar, Prado Prieto, Gustavo Hernán, Redondo Carrero, Emilio Vicente, Rojas Gutiérrez Gandarilla, José Luis De, San Martín Molina, Alicia, Guiteras Mombiola, Anna, Santis Miranda, Ángel Sebastián de, Romero Luna, Diego, Bordas Pérez, Irene Lin, Ortiz Nieto-Márquez, Irene, Ruz Barrio, Miguel Ángel, Batalla Rosado, Juan José, Bordón Ojeda, Marisa Leonor, Díaz Baiges, David, Gil García, Francisco Miguel, Luque Talaván, Miguel, Moreno Amador, Carlos, Muñoz Morán, Óscar, Prado Prieto, Gustavo Hernán, Redondo Carrero, Emilio Vicente, Rojas Gutiérrez Gandarilla, José Luis De, San Martín Molina, Alicia, Guiteras Mombiola, Anna, Santis Miranda, Ángel Sebastián de, Romero Luna, Diego, Bordas Pérez, Irene Lin, and Ortiz Nieto-Márquez, Irene

Published
2024

40. Els darrers volums de la Catalunya Carolíngia

Author

Baiges Jardí, Ignasi J. and Baiges Jardí, Ignasi J.

Abstract

Aquesta contribució al Congrés Homenatge a Ramon d’Abadal i Vinyals (1888-1970), presenta els volums de la col·lecció Catalunya carolíngia publicats després de la mort del seu creador i impulsor, Ramon d’Abadal i de Vinyals, que completen la part del diplomatari de l’obra tal com havia estat planificada. Se centra, doncs, en els volums IV a VIII de la col·lecció., This contribution to the Congress Tribute to Ramon d’Abadal i de Vinyals (1888-1970), presents the volumes of the collection Catalunya carolíngia published after the death of its creator and promoter, Ramon d’Abadal i de Vinyals, which complete the part of the diplomat of the work as planned. It therefore focuses on volumes IV to VIII of the collection.

Published
2024

41. Stress–displacement stabilized finite element analysis of thin structures using Solid-Shell elements. Part II: Finite strain hyperelasticity

Author

Universitat Politècnica de Catalunya. Doctorat en Anàlisi Estructural, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ANiComp - Anàlisi Numèrica i Computació Científica, Aguirre Ruz, Alejandro, Codina, Ramon, Baiges Aznar, Joan, Castañar Pérez, Inocencio, Universitat Politècnica de Catalunya. Doctorat en Anàlisi Estructural, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ANiComp - Anàlisi Numèrica i Computació Científica, Aguirre Ruz, Alejandro, Codina, Ramon, Baiges Aznar, Joan, and Castañar Pérez, Inocencio

Abstract

This work is the second of a two-part research project focused on modeling solid-shell elements using a stabilized two-field finite element formulation. The first part introduces a stabilization technique based on the Variational Multiscale framework, which is proven to effectively address numerical locking in infinitesimal strain problems. The primary objective of the study was to characterize the inherent numerical locking effects of solid-shell elements in order to comprehensively understand their triggers and how stabilized mixed formulations can overcome them. In this current phase of the work, the concept is extended to finite strain solid dynamics involving hyperelastic materials. The aim of introducing this method is to obtain a robust stabilized mixed formulation that enhances the accuracy of the stress field. This improved formulation holds great potential for accurately approximating shell structures undergoing finite deformations. To this end, three techniques based in the Variational Multiscale stabilization framework are presented. These stabilized formulations allow circumventing the compatibility restriction of interpolating spaces of the unknowns inherent to mixed formulations, thus allowing any combination of them. The accuracy of the stress field is successfully enhanced while maintaining the accuracy of the displacement field. These improvements are also inherited to the solid-shell elements, providing locking-free approximation of thin structures., This work was supported by Vicerrectoría de Investigación, Desarrollo e Innovación (VRIDEI) of the Univeridad de Santiago de Chile, and the National Agency for Research and Development (ANID) Doctorado Becas Chile/2019 - 72200128 of the Government of Chile. I. Castañar gratefully acknowledges the support received from the Agència de Gestió d’Ajut i de Recerca through the predoctoral FI grant 2019-FI-B-00649. R. Codina gratefully acknowledges the support received through the ICREA Acadèmia Research Program of the Catalan Government. This work was partially funded through the TOPFSI-APP: Ref. PDC2022-133581-I00 MICINN of the Spanish Government. CIMNE is a recipient of a “Severo Ochoa Programme for Centers of Excellence in R&D” grant (CEX2018-000797-S) by the Spanish Ministry of Economy and Competitiveness ., Peer Reviewed, Postprint (published version)

Published
2024

42. Stress–displacement stabilized finite element analysis of thin structures using solid-shell elements. Part I: On the need of interpolating the stresses

Author

Universitat Politècnica de Catalunya. Doctorat en Anàlisi Estructural, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ANiComp - Anàlisi Numèrica i Computació Científica, Aguirre Ruz, Alejandro, Codina, Ramon, Baiges Aznar, Joan, Universitat Politècnica de Catalunya. Doctorat en Anàlisi Estructural, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. ANiComp - Anàlisi Numèrica i Computació Científica, Aguirre Ruz, Alejandro, Codina, Ramon, and Baiges Aznar, Joan

Abstract

This work studies the solid-shell finite element approach to approximate thin structures using a stabilized mixed displacement-stress formulation based on the Variational Multiscale framework. The work is divided in two parts. In Part I, the numerical locking effects inherent to the solid-shell approach are characterized using a variety of benchmark problems in the infinitesimal strain approximation. In Part II, the results are extended to formulate the mixed approach in finite strain hyperelastic problems. In the present work, the stabilized mixed displacement-stress formulation is proven to be adequate to deal with all kinds of numerical locking. Additionally, a more comprehensive analysis of each individual type of numerical locking, how it is triggered and how it is overcome is also provided. The numerical locking usually occurs when parasitic strains overtake the system of equations through specific components of the stress tensor. To properly analyze them, the direction of each component of the stress tensor has been defined with respect to the shell directors. Therefore, it becomes necessary to formulate the solid-shell problem in curvilinear coordinates, allowing to give mechanical meaning to the stress components (shear, twisting, membrane and thickness stresses) independently of the global frame of reference. The conditions in which numerical locking is triggered as well as the stress tensor component responsible of correcting the locking behavior have been identified individually by characterizing the numerical response of a set of different benchmark problems., Peer Reviewed, Postprint (published version)

Published
2024

43. El pueblo gunadule a través de la mirada fotográfica de los misioneros carmelitas descalzos en la prefectura apostólica de Urabá, Colombia (1918-1941)

Author

David Díaz Baiges

Subjects
historia, historia cultural, fotografías, colombia, obra misionera, población indígena, History (General), D1-2009, Latin America. Spanish America, F1201-3799, History of specific doctrines and movements. Heresies and schisms, BT1313-1480
Abstract

Desde finales del siglo XIX y durante el XX se produjo una reactivación de la actividad misional a nivel global. En Colombia, este renacer otorgó un papel protagónico a la Iglesia Católica en las tareas de incorporar a la nación a las poblaciones indígenas que vivían al margen del Estado. Los estudios que analizan el papel de las misiones en el avance estatal hacia territorios «baldíos» en Colombia no han tenido en cuenta las representaciones que los religiosos construyeron sobre los pueblos originarios que debían «civilizar». En estas representaciones se clasificó a dichas poblaciones a partir de criterios raciales y culturales que dotaban de sentido a la actuación misional y, a su vez, legitimaban el nuevo orden republicano. Por ello, en este artículo se analizan las representaciones que los misioneros carmelitas descalzos construyeron sobre el pueblo gunadule de la región del golfo de Urabá. Para emprender esta tarea utilizaremos unas fuentes poco trabajadas, las fotografías.

Published
2021
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44. Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease

Author

Noemí Cabré, Míriam Gil, Núria Amigó, Fedra Luciano-Mateo, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Elisabet Rodríguez-Tomàs, Anna Hernández-Aguilera, Helena Castañé, Marta París, Fàtima Sabench, Daniel Del Castillo, Jordi Camps, and Jorge Joven

Subjects
Medicine, Science
Abstract

Abstract Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.

Published
2021
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45. El pueblo gunadule a traves de la mirada fotografica de los misioneros carmelitas descalzos en la prefectura apostolica de Uraba, Colombia (1918-1941)/The Gunadule People Through the Photographic Gaze of the Barefoot Carmelite Missionaries in the Apostolic Prefecture of Uraba, Colombia (1918-1941)/O povo Gunadule atraves do olhar fotografico dos missionarios Carmelitas Descalcos da Prefeitura Apostolica de Uraba, Colombia (1918-1941)

Author

Baiges, David Díaz

Published
2021
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50. Serum DNA methylome of the colorectal cancer serrated pathway enables non‐invasive detection

Author

Gallardo‐Gómez, María, primary, Costas‐Ríos, Lara, additional, Garcia‐Prieto, Carlos A., additional, Álvarez‐Rodríguez, Lara, additional, Bujanda, Luis, additional, Barrero, Maialen, additional, Castells, Antoni, additional, Balaguer, Francesc, additional, Jover, Rodrigo, additional, Esteller, Manel, additional, Tardío Baiges, Antoni, additional, González‐Carreró Fojón, Joaquín, additional, Cubiella, Joaquín, additional, and De Chiara, Loretta, additional

Published
2023
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