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6 results on '"Bahnassawy, Lamiaa"'

1. Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations

Author

Bahnassawy, Lamiaa, Nicolaisen, Nathalie, Untucht, Christopher, Mielich-Süss, Benjamin, Reinhardt, Lydia, Ried, Janina S., Morawe, Martina P., Geist, Daniela, Finck, Anja, Käfer, Elke, Korffmann, Jürgen, Townsend, Matthew, Ravikumar, Brinda, Lakics, Viktor, Cik, Miroslav, and Reinhardt, Peter

Published
2024
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2. Functional characterization of a single nucleotide polymorphism associated with Alzheimer’s disease in a hiPSC-based neuron model

Author

Stolzenburg, Lindsay R., primary, Esmaeeli, Sahar, additional, Kulkarni, Ameya S., additional, Murphy, Erin, additional, Kwon, Taekyung, additional, Preiss, Christina, additional, Bahnassawy, Lamiaa, additional, Stender, Joshua D., additional, Manos, Justine D., additional, Reinhardt, Peter, additional, Rahimov, Fedik, additional, Waring, Jeffrey F., additional, and Ramathal, Cyril Y., additional

Published
2023
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3. Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (epsilon 2/epsilon 3/epsilon 4) and knock-out for the study of APOE biology in health and disease

Author

Schmid, Benjamin, Holst, Bjorn, Clausen, Christian, Bahnassawy, Lamiaa, Reinhardt, Peter, Bakker, Margot H. M., Diaz-Guerra, Eva, Vicario, Carlos, Martino-Adami, Pamela, V, Thoenes, Michaela, Ramirez, Alfredo, Flissbach, Klaus, Grezella, Clara, Bruestle, Oliver, Peitz, Michael, Ebneth, Andreas, Cabrera-Socorro, Alfredo, Schmid, Benjamin, Holst, Bjorn, Clausen, Christian, Bahnassawy, Lamiaa, Reinhardt, Peter, Bakker, Margot H. M., Diaz-Guerra, Eva, Vicario, Carlos, Martino-Adami, Pamela, V, Thoenes, Michaela, Ramirez, Alfredo, Flissbach, Klaus, Grezella, Clara, Bruestle, Oliver, Peitz, Michael, Ebneth, Andreas, and Cabrera-Socorro, Alfredo

Abstract

APOE genotype is the strongest genetic risk factor for Alzheimer's Disease (AD). The low degree of homology between mouse and human APOE is a concerning issue in preclinical models currently used to study the role of this gene in AD pathophysiology. A key objective of ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project was to generate in vitro models that better recapitulate human APOE biology. We describe a new set of induced pluripotent stem cells (iPSC) lines carrying common APOE variants (epsilon 2,epsilon 3, and epsilon 3/epsilon 4) and a knock-out isogenic to the parental APOE epsilon 4/epsilon 4 line (UKBi011-A).

Published
2021

4. Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease

Author

Schmid, Benjamin, primary, Holst, Bjørn, additional, Clausen, Christian, additional, Bahnassawy, Lamiaa, additional, Reinhardt, Peter, additional, Bakker, Margot H.M., additional, Díaz-Guerra, Eva, additional, Vicario, Carlos, additional, Martino-Adami, Pamela V., additional, Thoenes, Michaela, additional, Ramirez, Alfredo, additional, Fliessbach, Klaus, additional, Grezella, Clara, additional, Brüstle, Oliver, additional, Peitz, Michael, additional, Ebneth, Andreas, additional, and Cabrera-Socorro, Alfredo, additional

Published
2021
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6. TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation

Author

Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group) [research center], Hillje, Anna-Lena, Pavlou, Maria Angeliki, Beckmann, Elisabeth, Worlitzer, Maik, Bahnassawy, Lamiaa, Lewejohann, Lars, Palm, Thomas, Schwamborn, Jens Christian, Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group) [research center], Hillje, Anna-Lena, Pavlou, Maria Angeliki, Beckmann, Elisabeth, Worlitzer, Maik, Bahnassawy, Lamiaa, Lewejohann, Lars, Palm, Thomas, and Schwamborn, Jens Christian

Published
2013
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