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3. Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response

Author

BROZZETTI A, MARZOTTI S, LA TORRE D, BACOSI ML, MORELLI S, BINI V, AMBROSI B, GIORDANO R, PERNIOLA R, DE BELLIS, Annamaria, BETTERLE C, FALORNI A, ITALIAN ADDISON NETWORK, Brozzetti, A, Marzotti, S, LA TORRE, D, Bacosi, Ml, Morelli, S, Bini, V, Ambrosi, B, Giordano, R, Perniola, R, DE BELLIS, Annamaria, Betterle, C, Falorni, A, and ITALIAN ADDISON, Network

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Primary Ovarian Insufficiency, medicine.disease_cause, Subclass, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Addison Disease, Internal medicine, medicine, Adrenal insufficiency, Humans, Cholesterol Side-Chain Cleavage Enzyme, Child, Polyendocrinopathies, Autoimmune, 030304 developmental biology, Aged, Autoantibodies, 0303 health sciences, Chi-Square Distribution, biology, business.industry, Hypogonadism, Autoantibody, General Medicine, Middle Aged, medicine.disease, Isotype, 3. Good health, Autoimmune polyendocrine syndrome type 1, Addison's disease, Immunoglobulin G, Infertility, Immunology, biology.protein, Female, Immunoradiometric Assay, Steroid 21-Hydroxylase, Antibody, business
Abstract

ObjectiveSteroid-producing cell autoantibodies (SCAs) directed against 21-hydroxylase autoantibodies (21OHAbs), 17α-hydroxylase autoantibodies (17OHAb), and cholesterol side-chain cleavage enzyme (side-chain cleavage autoantibodies, P450sccAb) characterize autoimmune primary ovarian insufficiency (SCA-POI). The aim of the study was to analyze IgG subclass specificity of autoantibodies related to adrenal and ovarian autoimmunity.DesignWe studied 29 women with SCA-POI, 30 women with autoimmune Addison's disease (AAD) without POI, and 14 patients with autoimmune polyendocrine syndrome type 1 (APS1). 21OHAb isotypes were also analyzed in 14 subjects with preclinical AAD. Samples from 30 healthy women served as control group to determine the upper level of normality in the isotype assays.MethodsImmunoradiometric assays with IgG subclass-specific secondary antibodies.ResultsIn 21OHAb-positive sera, IgG1 isotype was detected in 90% SCA-POI and non-POI AAD sera and 67% APS1 patients. IgG1 isotype was found in 69% 17OHAb-positive SCA-POI and 100% 17OHAb-positive APS1 sera, and in 60% P450sccAb-positive SCA-POI and 80% P450sccAb-positive APS1 sera. For 21OHAb, IgG4 isotype was detected in 17% SCA-POI, 7% non-POI AAD, and 8% APS1 sera. None of the 17OHAb-positive sera was positive for IgG4. In P450sccAb-positive sera, 15% POI and 20% APS1 sera were positive for IgG4. Two 21OHAb-positive SCA-POI (7%), one 21OHAb-positive AAD (3%), three P450sccAb-positive SCA-POI (15%), and two P450sccAb-positive APS1 (20%) sera were positive for IgG4, in the absence of IgG1. All preclinical AAD sera resulted as positive for IgG1-21OHAb, but not for IgG4-21OHAb.ConclusionsThe autoantibody responses in POI and AAD are IgG1 dominated, which suggests a predominant Th1 response. Selective IgG4 isotype specificity identified a small subset of patients with Th2-oriented response.

Published
2010

6. Epidemiology of overweight and obesity among school children and adolescents in three provinces of central Italy, 1993-2001: study of potential influencing variables.

Author

Celi F, Bini V, De Giorgi G, Molinari D, Faraoni F, Di Stefano G, Bacosi ML, Berioli MG, Contessa G, and Falorni A

Subjects
Adolescent, Age Factors, Birth Order, Birth Weight physiology, Body Mass Index, Causality, Child, Child, Preschool, Female, Humans, Italy epidemiology, Logistic Models, Male, Menarche physiology, Parents, Prevalence, Risk Factors, Sex Distribution, Obesity epidemiology
Abstract

Objective: The prevalence of overweight and obesity was estimated among the school children and adolescents of three provinces of central Italy, and the role of several possible influencing factors was analysed., Design, Subjects and Measurements: Body mass index (BMI) was measured in 44 231 subjects, age 3-17.5 y, and a household questionnaire was filled out by the parents of 12 143 subjects to collect the following data: subjects, only child or firstborn status, prematurity, birth weight, type of feeding until the fifth month, menarche status in girls; parents, age at the time of the subject's birth; BMI (mean of the two parents) at the time the subject was measured, mother's age of menarche, socioeconomic status. BMI was measured in a subgroup of 10 795 subjects 1 y later to study the yearly sex- and age-related variations from the categories of normal weight to overweight or obesity and vice versa. All females aged 11-14 y were asked if they had their menarche., Results: Striking differences in the proportions of overweight and obesity resulted from the use of two different criteria for defining cutoff points. The overall prevalence of overweight was 13.2 and 20.7% in males, and 13.7 and 18.6% in females, and the overall prevalence of obesity varied between 24.2 and 6.3% in males, and between 22.9 and 6.1% in females, respectively. Parents' BMI, birth weight, firstborn status and post-menarche status in girls showed a significant association with overweight and/or obesity in logistic regression models., Conclusions: A large prevalence of overweight and obesity was observed in school subjects from three provinces of central Italy. From the comparisons of the prevalence rate, the new internationally agreed criteria seem more appropriate for epidemiological studies in this population., Sponsor: University of Perugia, Region of Umbria, Commune of Perugia.

Published
2003
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