1. Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation
- Author
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Jeanine E. Vasmel, MD, Maureen L. Groot Koerkamp, MSc, Stefano Mandija, PhD, Wouter B. Veldhuis, PhD, Maaike R. Moman, PhD, Martijn Froeling, PhD, Bas H.M. van der Velden, PhD, Ramona K. Charaghvandi, PhD, Celien P.H. Vreuls, PhD, Paul J. van Diest, PhD, A.M. Gijs van Leeuwen, MD, Joost van Gorp, PhD, Marielle E.P. Philippens, PhD, Bram van Asselen, PhD, Jan J.W. Lagendijk, PhD, Helena M. Verkooijen, PhD, H.J.G. Desirée van den Bongard, PhD, and Antonetta C. Houweling, PhD
- Subjects
Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: We aimed to evaluate changes in dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) scans acquired before and after single-dose ablative neoadjuvant partial breast irradiation (NA-PBI), and explore the relation between semiquantitative MRI parameters and radiologic and pathologic responses. Methods and Materials: We analyzed 3.0T DCE and DW-MRI of 36 patients with low-risk breast cancer who were treated with single-dose NA-PBI, followed by breast-conserving surgery 6 or 8 months later. MRI was acquired before NA-PBI and 1 week, 2, 4, and 6 months after NA-PBI. Breast radiologists assessed the radiologic response and breast pathologists scored the pathologic response after surgery. Patients were grouped as either pathologic responders or nonresponders (
- Published
- 2022
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