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2 results on '"Amofah GK"'

1. The Affordable Medicines Facility-malaria--a success in peril.

Author

Talisuna AO, Adibaku S, Amojah CN, Amofah GK, Aubyn V, Dodoo A, Juma E, Jackou DH, Mkude S, Okui AP, Ramarosandratana B, and Shija SJ

Subjects
Africa, Drug Therapy, Combination economics, Drug Therapy, Combination methods, Drug Utilization statistics & numerical data, Humans, Treatment Outcome, Antimalarials economics, Antimalarials therapeutic use, Artemisinins economics, Artemisinins therapeutic use, Health Services Accessibility statistics & numerical data, Lactones economics, Lactones therapeutic use, Malaria drug therapy
Abstract

The Affordable Medicines Facility-malaria (AMFm) has put into place a bold financing plan for artemisinin-combination therapy in a pilot phase in seven countries covering half the population at risk of malaria in Africa. A report of the AMFm independent evaluation, conducted by ICF International and the London School of Hygiene and Tropical Medicine, describes the success of the programme in the pilot sites: Ghana, Kenya, Madagascar, Niger, Nigeria, Tanzania (mainland and Zanzibar) and Uganda, comparing availability and affordability of high-quality artemisinin-combination therapies before and after AMFm launched. Proof of concept was achieved: AMFm increased availability and kept prices low, meeting its initial, ambitious benchmarks in most settings. Despite this overwhelming success, opposition to the programme and dwindling resources for malaria control conspire to cripple or kill AMFm.

Published
2012
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2. Risk factors for Buruli ulcer disease (Mycobacterium ulcerans Infection): results from a case-control study in Ghana.

Author

Raghunathan PL, Whitney EA, Asamoa K, Stienstra Y, Taylor TH Jr, Amofah GK, Ofori-Adjei D, Dobos K, Guarner J, Martin S, Pathak S, Klutse E, Etuaful S, van der Graaf WT, van der Werf TS, King CH, Tappero JW, and Ashford DA

Subjects
Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Female, Ghana epidemiology, Humans, Infant, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors, Sex Characteristics, Skin Ulcer epidemiology, Mycobacterium Infections, Nontuberculous epidemiology, Mycobacterium Infections, Nontuberculous microbiology, Mycobacterium ulcerans isolation & purification, Skin Ulcer microbiology
Abstract

Background: Morbidity due to Buruli ulcer disease (BUD), a cutaneous infection caused by Mycobacterium ulcerans, has been increasingly recognized in rural West Africa. The source and mode of transmission remain unknown., Methods: To identify BUD risk factors, we conducted a case-control study in 3 BUD-endemic districts in Ghana. We enrolled case patients with clinically diagnosed BUD and obtained skin biopsy specimens. M. ulcerans infection was confirmed by at least 1 of the following diagnostic methods: histopathologic analysis, culture, polymerase chain reaction, and Ziehl-Neelsen staining of a lesion smear. We compared characteristics of case patients with confirmed BUD with those of age- and community-matched control subjects using conditional logistic regression analysis., Results: Among 121 case patients with confirmed BUD, leg lesions (49%) or arm lesions (36%) were common. Male case patients were significantly more likely than female case patients to have lesions on the trunk (25% vs. 6%; P = .009). Multivariable modeling among 116 matched case-control pairs identified wading in a river as a risk factor for BUD (odds ratio [OR], 2.69; 95% confidence interval [CI], 1.27-5.68; P = .0096). Wearing a shirt while farming (OR, 0.27; 95% CI, 0.11-0.70; P = .0071), sharing indoor living space with livestock (OR, 0.36; 95% CI, 0.15-0.86; P = .022), and bathing with toilet soap (OR, 0.41; 95% CI, 0.19-0.90; P = .026) appeared to be protective. BUD was not significantly associated with penetrating injuries (P = .14), insect bites near water bodies (P = .84), bacille Calmette-Guerin vaccination (P = .33), or human immunodeficiency virus infection (P = .99)., Conclusions: BUD is an environmentally acquired infection strongly associated with exposure to river areas. Exposed skin may facilitate transmission. Until transmission is better defined, control strategies in BUD-endemic areas could include covering exposed skin.

Published
2005
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