1. Association of In-Hospital Surgical Bleeding Events with Prolonged Hospital Length of Stay, Days Spent in Critical Care, Complications, and Mortality: A Retrospective Cohort Study Among Patients Undergoing Neoplasm-Directed Surgeries in English Hospitals
- Author
-
Johnston SS, Jamous N, Mistry S, Jain S, Gangoli G, Danker W, Ammann E, and Hampton K
- Subjects
hysterectomy ,low anterior resection ,lung resection ,mastectomy ,prostate surgery ,hospital episode statistics admitted patient care database ,clinical practice research datalink gold database ,Medicine (General) ,R5-920 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Stephen S Johnston,1 Nadine Jamous,2 Sameer Mistry,3 Simran Jain,4 Gaurav Gangoli,5 Walter Danker,5 Eric Ammann,6 Kingsley Hampton7 1Department of Epidemiology, Medical Devices, Johnson & Johnson, New Brunswick, NJ, USA; 2Department of Health Economics and Market Access, Johnson & Johnson Medical Ltd, Edinburgh, UK; 3Department of Medical Affairs, Johnson & Johnson Medical Ltd, Berkshire, UK; 4Department of Decision Science, Mu Sigma, Bangalore, India; 5Department of Health Economics and Market Access, Ethicon, Inc, Somerville, NJ, USA; 6Department of Epidemiology, Janssen, Titusville, NJ, USA; 7Department of Cardiovascular Science, University of Sheffield, Sheffield, UKCorrespondence: Stephen S JohnstonDepartment of Epidemiology, Medical Devices, Johnson & Johnson, 410 George Street, New Brunswick, NJ 08901, USATel +1-443-254-2222Email sjohn147@its.jnj.comPurpose: To evaluate the association of in-hospital surgical bleeding events with the outcomes of hospital length of stay (LOS), days spent in critical care, complications, and mortality among patients undergoing neoplasm-directed surgeries in English hospitals.Patients and Methods: This is a retrospective cohort study using English hospital discharge data (Hospital Episode Statistics [HES]) linked to electronic health records (Clinical Practice Research Datalink [CPRD]). HES includes information on patient demographics, admission and discharge dates, diagnoses and procedures, days spent in critical care, and discharge status. CPRD includes information on patient demographics, diagnoses and symptoms, drug exposures, vaccination history, and laboratory tests. Patients aged ≥ 18 years who underwent selected neoplasm-directed surgeries between 1-Jan-2010 and 29-February-2016: hysterectomy, low anterior resection (LAR), lung resection, mastectomy, and prostate surgery were included. The primary independent variable was in-hospital surgical bleeding events identified by diagnosis of haemorrhage and haematoma complicating a procedure or reopening/re-exploration and surgical arrest of postoperative bleeding. Outcomes included LOS, days spent in critical care, in-hospital complications (diagnoses of infections, acute renal failure, vascular events), and in-hospital mortality, identified during surgery through discharge. Multivariable regression was used to examine the adjusted association of bleeding events with outcomes.Results: The study included 26,437 neoplasm-directed surgeries (hysterectomy=6092; LAR=2957; lung=1538; mastectomy=12,806; prostate=3044). Incidence proportions of bleeding events were: hysterectomy=1.9% (95% confidence interval=1.1– 2.5%); LAR=3.0% (CI=2.3– 3.6%); lung=1.8% (CI=1.1– 2.5%); mastectomy=1.6% (CI=1.3– 1.8%); prostate=1.0% (CI=0.6– 1.3%). In adjusted analyses, bleeding events were associated with: prolonged LOS: 3.1 (CI=1.1– 6.3) mastectomy to 5.7 (CI=3.6– 8.2) LAR days longer; more days spent in critical care: 0.4 (CI=0.03– 0.27) mastectomy to 6.5 (CI=2.5– 13.6) hysterectomy days more; and higher incidence proportions of all examined complications; all P< 0.05.Conclusion: This study quantifies a substantial clinical and healthcare resource utilization burden associated with surgical bleeding among patients undergoing neoplasm-directed surgery in England hospitals.Keywords: hysterectomy, low anterior resection, lung resection, mastectomy, prostate surgery, hospital episode statistics admitted patient care database, clinical practice research datalink GOLD database
- Published
- 2021