1. Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait.
- Author
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Wani VB, Al-Kandari J, Sabti K, Aljassar F, Qali H, Kumar N, Uboweja A, Al-Sabah K, Diab FA, and Al-Rashidi S
- Subjects
- Aged, Angiogenesis Inhibitors chemistry, Anti-Bacterial Agents therapeutic use, Bevacizumab chemistry, Drug Compounding, Endophthalmitis drug therapy, Endophthalmitis microbiology, Eye Infections, Bacterial drug therapy, Eye Infections, Bacterial microbiology, Female, Humans, Incidence, Intravitreal Injections, Kuwait epidemiology, Macular Degeneration drug therapy, Macular Edema drug therapy, Male, Middle Aged, Operating Rooms, Pneumococcal Infections drug therapy, Pneumococcal Infections microbiology, Retrospective Studies, Staphylococcus lugdunensis isolation & purification, Streptococcal Infections drug therapy, Streptococcal Infections microbiology, Streptococcus pneumoniae isolation & purification, Vascular Endothelial Growth Factor A antagonists & inhibitors, Visual Acuity, Angiogenesis Inhibitors therapeutic use, Bevacizumab therapeutic use, Endophthalmitis epidemiology, Eye Infections, Bacterial epidemiology, Pneumococcal Infections epidemiology, Streptococcal Infections epidemiology
- Abstract
Purpose: To report the incidence of endophthalmitis after intravitreal injection of bevacizumab and the outcomes of treatment of endophthalmitis at two centers in Kuwait., Subjects and Methods: The aliquots of bevacizumab were prepared under aseptic precautions and administered in the operating theater on the same day at both centers. All patients received antibiotic drops after injection of bevacizumab. Data were collected on the number of cases that received intravitreal bevacizumab (IVB) and those that developed endophthalmitis were identified at the two centers. All cases of endophthalmitis received an intravitreal antibiotic injection and additional treatments as warranted. Data were collected on the outcomes of endophthalmitis treatment., Results: There were 5 cases of endophthalmitis among a total of 5429 injections (0.09%: Confidence interval: 0.084-0.1). The incidence was 3 cases among 4690 (0.06%) and 2 cases among 739 injections (0.027%) at each center, respectively (P = 0.08). Four cases of endophthalmitis were culture-positive and organisms isolated were, coagulase negative Staphylococcus in 2 cases, Staphylococcus lugdunensis and Streptococcus pneumoniae in 1 case each. The final visual acuity was better than pre-IVB in 3 cases, same as pre-IVB in 1 case and worse in 1 case with streptococcal infection. No eyes developed phthisis bulbi or required enucleation., Conclusions: The incidence of endophthalmitis after intravitreal injection of bevacizumab using aliquots prepared in the operating room is comparable to other studies. There were no clusters of endophthalmitis cases.
- Published
- 2016
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