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20 results on '"Alexander, Kevin M."'

1. Heart Failure Epidemiology and Outcomes Statistics: A Report of the Heart Failure Society of America

Author

Bozkurt, Biykem, Ahmad, Tariq, Alexander, Kevin M, Baker, William L, Bosak, Kelly, Breathett, Khadijah, Fonarow, Gregg C, Heidenreich, Paul, Ho, Jennifer E, Hsich, Eileen, Ibrahim, Nasrien E, Jones, Lenette M, Khan, Sadiya S, Khazanie, Prateeti, Koelling, Todd, Krumholz, Harlan M, Khush, Kiran K, Lee, Christopher, Morris, Alanna A, Page, Robert L, Pandey, Ambarish, Piano, Mariann R, Stehlik, Josef, Stevenson, Lynne Warner, Teerlink, John R, Vaduganathan, Muthiah, Ziaeian, Boback, and Members, Writing Committee

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Humans, Heart Failure, Hospitalization, Prevalence, Incidence, Writing Committee Members, Heart failure, epidemiology, incidence, mortality, outcomes, prevalence, Cardiorespiratory Medicine and Haematology, Nursing, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Published
2023

2. High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy with Cardiovascular Deep Learning

Author

Duffy, Grant, Cheng, Paul P, Yuan, Neal, He, Bryan, Kwan, Alan C., Shun-Shin, Matthew J., Alexander, Kevin M., Ebinger, Joseph, Lungren, Matthew P., Rader, Florian, Liang, David H., Schnittger, Ingela, Ashley, Euan A., Zou, James Y., Patel, Jignesh, Witteles, Ronald, Cheng, Susan, and Ouyang, David

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Left ventricular hypertrophy (LVH) results from chronic remodeling caused by a broad range of systemic and cardiovascular disease including hypertension, aortic stenosis, hypertrophic cardiomyopathy, and cardiac amyloidosis. Early detection and characterization of LVH can significantly impact patient care but is limited by under-recognition of hypertrophy, measurement error and variability, and difficulty differentiating etiologies of LVH. To overcome this challenge, we present EchoNet-LVH - a deep learning workflow that automatically quantifies ventricular hypertrophy with precision equal to human experts and predicts etiology of LVH. Trained on 28,201 echocardiogram videos, our model accurately measures intraventricular wall thickness (mean absolute error [MAE] 1.4mm, 95% CI 1.2-1.5mm), left ventricular diameter (MAE 2.4mm, 95% CI 2.2-2.6mm), and posterior wall thickness (MAE 1.2mm, 95% CI 1.1-1.3mm) and classifies cardiac amyloidosis (area under the curve of 0.83) and hypertrophic cardiomyopathy (AUC 0.98) from other etiologies of LVH. In external datasets from independent domestic and international healthcare systems, EchoNet-LVH accurately quantified ventricular parameters (R2 of 0.96 and 0.90 respectively) and detected cardiac amyloidosis (AUC 0.79) and hypertrophic cardiomyopathy (AUC 0.89) on the domestic external validation site. Leveraging measurements across multiple heart beats, our model can more accurately identify subtle changes in LV geometry and its causal etiologies. Compared to human experts, EchoNet-LVH is fully automated, allowing for reproducible, precise measurements, and lays the foundation for precision diagnosis of cardiac hypertrophy. As a resource to promote further innovation, we also make publicly available a large dataset of 23,212 annotated echocardiogram videos.

Published
2021
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4. Pulling at the heart: COVID-19, race/ethnicity and ongoing disparities

Author

Chin-Hong, Peter, Alexander, Kevin M, Haynes, Norrisa, and Albert, Michelle A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Behavioral and Social Science, Heart Disease, Cardiovascular, Good Health and Well Being, Antiviral Agents, Betacoronavirus, Black People, COVID-19, Cardiovascular Diseases, Comorbidity, Coronavirus Infections, Health Services Accessibility, Health Services Needs and Demand, Health Status Disparities, Healthcare Disparities, Humans, Mortality, Pandemics, Pneumonia, Viral, Prevalence, SARS-CoV-2, United States, Association of Black Cardiologists, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Social determinants of health in the African diaspora drive the lack of disease testing, increased prevalence of comorbid disease and reduced access to drugs, resulting in disproportionately higher COVID-19-related mortality among Black individuals than the rest of the population. We urge decisive attention to and action against ethnicity-based inequities that undermine cardiovascular health.

Published
2020

8. Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial

Author

Sharma, Kavita, Vaishnav, Joban, Kalathiya, Rohan, Hu, Jiun-Ruey, Miller, John, Shah, Nishant, Hill, Terence, Sharp, Michelle, Tsao, Allison, Alexander, Kevin M., Gupta, Richa, Montemayor, Kristina, Kovell, Lara, Chasler, Jessica E., Lee, Yizhen J., Fine, Derek M., Kass, David A., Weiss, Robert G., Thiemann, David R., Ndumele, Chiadi E., Schulman, Steven P., and Russell, Stuart D.

Published
2018
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9. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Author

Schimmel, Katharina, Jung, Mira, Foinquinos, Ariana, José, Gorka San, Beaumont, Javier, Bock, Katharina, Grote-Levi, Lea, Xiao, Ke, Bär, Christian, Pfanne, Angelika, Just, Annette, Zimmer, Karina, Ngoy, Soeun, López, Begoña, Ravassa, Susana, Samolovac, Sabine, Janssen-Peters, Heike, Remke, Janet, Scherf, Kristian, Dangwal, Seema, Piccoli, Maria-Teresa, Kleemiss, Felix, Kreutzer, Fabian Philipp, Kenneweg, Franziska, Leonardy, Julia, Hobuß, Lisa, Santer, Laura, Do, Quoc-Tuan, Geffers, Robert, Braesen, Jan Hinrich, Schmitz, Jessica, Brandenberger, Christina, Müller, Dominik N., Wilck, Nicola, Kaever, Volkhard, Bähre, Heike, Batkai, Sandor, Fiedler, Jan, Alexander, Kevin M., Wertheim, Bradley M., Fisch, Sudeshna, Liao, Ronglih, Diez, Javier, González, Arantxa, and Thum, Thomas

Published
2020
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10. Nurturing Diverse Generations of the Medical Workforce for Success With Authenticity: An Association of Black Cardiologists’ Roundtable

Author

Haynes, Norrisa A., primary, Johnson, Michelle, additional, Lewsey, Sabra C., additional, Alexander, Kevin M., additional, Anstey, D. Edmund, additional, Dillenburg, Tierra, additional, Njoroge, Joyce N., additional, Gordon, Debra, additional, Ofili, Elizabeth O., additional, Yancy, Clyde W., additional, and Albert, Michelle A., additional

Published
2023
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13. Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support

Author

Birati, Edo Y., primary, Najjar, Samer S., additional, Tedford, Ryan J., additional, Houston, Brian A., additional, Shore, Supriya, additional, Vorovich, Esther, additional, Atluri, Pavan, additional, Urgo, Kimberly, additional, Molina, Maria, additional, Chambers, Susan, additional, Escobar, Nicole, additional, Hsich, Eileen, additional, Estep, Jerry D., additional, Alexander, Kevin M., additional, Teuteberg, Jeffrey J., additional, Chaudhry, Sunit-Preet, additional, Ravichandran, Ashwin, additional, DeVore, Adam D., additional, Margulies, Kenneth B., additional, Hanff, Thomas C., additional, Zimmer, Ross, additional, Kilic, Arman, additional, Wald, Joyce W., additional, Vidula, Himabindu, additional, Martens, John, additional, Blumberg, Emily A., additional, Mazurek, Jeremy A., additional, Owens, Anjali T., additional, Goldberg, Lee R., additional, Alvarez-Garcia, Jesus, additional, Mancini, Donna M., additional, Moss, Noah, additional, and Genuardi, Michael V., additional

Published
2021
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