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1. Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Author

Heike Stein, Joao Barbosa, Mireia Rosa-Justicia, Laia Prades, Alba Morató, Adrià Galan-Gadea, Helena Ariño, Eugenia Martinez-Hernandez, Josefina Castro-Fornieles, Josep Dalmau, and Albert Compte

Subjects
Science
Abstract

Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.

Published
2020
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2. Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Author

João Barbosa, Helena Ariño, Heike Stein, Adrià Galan, Josep Dalmau, Josefina Castro-Fornieles, Laia Prades, Alba Morató, Albert Compte, Eugenia Martinez-Hernandez, and Mireia Rosa-Justicia

Subjects
0303 health sciences, business.industry, Long-term potentiation, Anti-NMDAR Encephalitis, medicine.disease, 03 medical and health sciences, Neural activity, 0302 clinical medicine, Schizophrenia, Medicine, business, Cortical excitation, Neuroscience, 030217 neurology & neurosurgery, Serial dependence, Encephalitis, 030304 developmental biology
Abstract

We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. We argue that NMDAR-related changes in cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support a disruption of a memory mechanism operating on a longer timescale, such as short-term potentiation.

Published
2019
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