29 results on '"Adiego, B."'
Search Results
2. Comparison of different methods of first‐trimester screening for preterm pre‐eclampsia: cohort study.
- Author
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Cuenca‐Gómez, D., De Paco Matallana, C., Rolle, V., Mendoza, M., Valiño, N., Revello, R., Adiego, B., Casanova, M. C., Molina, F. S., Delgado, J. L., Wright, A., Figueras, F., Nicolaides, K. H., Santacruz, B., and Gil, M. M.
- Subjects
MEDICAL screening ,PREECLAMPSIA ,PLACENTAL growth factor ,OBSTETRICS ,PREGNANT women ,MOLAR pregnancy ,ECLAMPSIA - Abstract
Objective: To compare the predictive performance of three different mathematical models for first‐trimester screening of pre‐eclampsia (PE), which combine maternal risk factors with mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI) and serum placental growth factor (PlGF), and two risk‐scoring systems. Methods: This was a prospective cohort study performed in eight fetal medicine units in five different regions of Spain between September 2017 and December 2019. All pregnant women with singleton pregnancy and a non‐malformed live fetus attending their routine ultrasound examination at 11 + 0 to 13 + 6 weeks' gestation were invited to participate in the study. Maternal characteristics and medical history were recorded and measurements of MAP, UtA‐PI, serum PlGF and pregnancy‐associated plasma protein‐A (PAPP‐A) were converted into multiples of the median (MoM). Risks for term PE, preterm PE (< 37 weeks' gestation) and early PE (< 34 weeks' gestation) were calculated according to the FMF competing‐risks model, the Crovetto et al. logistic regression model and the Serra et al. Gaussian model. PE classification was also performed based on the recommendations of the National Institute for Health and Care Excellence (NICE) and the American College of Obstetricians and Gynecologists (ACOG). We estimated detection rates (DR) with their 95% CIs at a fixed 10% screen‐positive rate (SPR), as well as the area under the receiver‐operating‐characteristics curve (AUC) for preterm PE, early PE and all PE for the three mathematical models. For the scoring systems, we calculated DR and SPR. Risk calibration was also assessed. Results: The study population comprised 10 110 singleton pregnancies, including 32 (0.3%) that developed early PE, 72 (0.7%) that developed preterm PE and 230 (2.3%) with any PE. At a fixed 10% SPR, the FMF, Crovetto et al. and Serra et al. models detected 82.7% (95% CI, 69.6–95.8%), 73.8% (95% CI, 58.7–88.9%) and 79.8% (95% CI, 66.1–93.5%) of early PE; 72.7% (95% CI, 62.9–82.6%), 69.2% (95% CI, 58.8–79.6%) and 74.1% (95% CI, 64.2–83.9%) of preterm PE; and 55.1% (95% CI, 48.8–61.4%), 47.1% (95% CI, 40.6–53.5%) and 53.9% (95% CI, 47.4–60.4%) of all PE, respectively. The best correlation between predicted and observed cases was achieved by the FMF model, with an AUC of 0.911 (95% CI, 0.879–0.943), a slope of 0.983 (95% CI, 0.846–1.120) and an intercept of 0.154 (95% CI, –0.091 to 0.397). The NICE criteria identified 46.7% (95% CI, 35.3–58.0%) of preterm PE at 11% SPR and ACOG criteria identified 65.9% (95% CI, 55.4–76.4%) of preterm PE at 33.8% SPR. Conclusions: The best performance of screening for preterm PE is achieved by mathematical models that combine maternal factors with MAP, UtA‐PI and PlGF, as compared to risk‐scoring systems such as those of NICE and ACOG. While all three algorithms show similar results in terms of overall prediction, the FMF model showed the best performance at an individual level. © 2024 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
3. OP13.09: Validating the machine learning model for first trimester prediction of pre‐eclampsia using a cohort from Spain
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Gil, M., primary, Rolle, V., additional, Gómez, D. C., additional, Valiño, N., additional, Revello, R., additional, Adiego, B., additional, Ansbacher‐Feldman, Z., additional, Meiri, H., additional, Louzoun, Y., additional, Santacruz, B., additional, and de Paco Matallana, C., additional
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- 2023
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4. Validating a machine‐learning model for first‐trimester prediction of pre‐eclampsia using the cohort from the PREVAL study
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Gil, M. M., primary, Cuenca‐Gómez, D., additional, Rolle, V., additional, Pertegal, M., additional, Díaz, C., additional, Revello, R., additional, Adiego, B., additional, Mendoza, M., additional, Molina, F. S., additional, Santacruz, B., additional, Ansbacher‐Feldman, Z., additional, Meiri, H., additional, Martin‐Alonso, R., additional, Louzoun, Y., additional, and de Paco Matallana, C., additional
- Published
- 2023
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5. Validation of machine‐learning model for first‐trimester prediction of pre‐eclampsia using cohort from PREVAL study.
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Gil, M. M., Cuenca‐Gómez, D., Rolle, V., Pertegal, M., Díaz, C., Revello, R., Adiego, B., Mendoza, M., Molina, F. S., Santacruz, B., Ansbacher‐Feldman, Z., Meiri, H., Martin‐Alonso, R., Louzoun, Y., and De Paco Matallana, C.
- Subjects
PLACENTAL growth factor ,PREECLAMPSIA ,MACHINE learning ,UTERINE artery ,ARTIFICIAL intelligence - Abstract
Objective: Effective first‐trimester screening for pre‐eclampsia (PE) can be achieved using a competing‐risks model that combines risk factors from the maternal history with multiples of the median (MoM) values of biomarkers. A new model using artificial intelligence through machine‐learning methods has been shown to achieve similar screening performance without the need for conversion of raw data of biomarkers into MoM. This study aimed to investigate whether this model can be used across populations without specific adaptations. Methods: Previously, a machine‐learning model derived with the use of a fully connected neural network for first‐trimester prediction of early (< 34 weeks), preterm (< 37 weeks) and all PE was developed and tested in a cohort of pregnant women in the UK. The model was based on maternal risk factors and mean arterial blood pressure (MAP), uterine artery pulsatility index (UtA‐PI), placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A). In this study, the model was applied to a dataset of 10 110 singleton pregnancies examined in Spain who participated in the first‐trimester PE validation (PREVAL) study, in which first‐trimester screening for PE was carried out using the Fetal Medicine Foundation (FMF) competing‐risks model. The performance of screening was assessed by examining the area under the receiver‐operating‐characteristics curve (AUC) and detection rate (DR) at a 10% screen‐positive rate (SPR). These indices were compared with those derived from the application of the FMF competing‐risks model. The performance of screening was poor if no adjustment was made for the analyzer used to measure PlGF, which was different in the UK and Spain. Therefore, adjustment for the analyzer used was performed using simple linear regression. Results: The DRs at 10% SPR for early, preterm and all PE with the machine‐learning model were 84.4% (95% CI, 67.2–94.7%), 77.8% (95% CI, 66.4–86.7%) and 55.7% (95% CI, 49.0–62.2%), respectively, with the corresponding AUCs of 0.920 (95% CI, 0.864–0.975), 0.913 (95% CI, 0.882–0.944) and 0.846 (95% CI, 0.820–0.872). This performance was achieved with the use of three of the biomarkers (MAP, UtA‐PI and PlGF); inclusion of PAPP‐A did not provide significant improvement in DR. The machine‐learning model had similar performance to that achieved by the FMF competing‐risks model (DR at 10% SPR, 82.7% (95% CI, 69.6–95.8%) for early PE, 72.7% (95% CI, 62.9–82.6%) for preterm PE and 55.1% (95% CI, 48.8–61.4%) for all PE) without requiring specific adaptations to the population. Conclusions: A machine‐learning model for first‐trimester prediction of PE based on a neural network provides effective screening for PE that can be applied in different populations. However, before doing so, it is essential to make adjustments for the analyzer used for biochemical testing. © 2023 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
6. Performance of first‐trimester combined screening of preterm pre‐eclampsia: results from cohort of 10 110 pregnancies in Spain
- Author
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Gómez, D. Cuenca, primary, De Paco Matallana, C., additional, Rolle, V., additional, Valiño, N., additional, Revello, R., additional, Adiego, B., additional, Mendoza, M., additional, Molina, F. S., additional, Carrillo, M. P., additional, Delgado, J. L., additional, Wright, A., additional, Santacruz, B., additional, and Gil, M. M., additional
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- 2023
- Full Text
- View/download PDF
7. Performance of first‐trimester combined screening for preterm pre‐eclampsia: findings from cohort of 10 110 pregnancies in Spain.
- Author
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Cuenca‐Gómez, D., de Paco Matallana, C., Rolle, V., Valiño, N., Revello, R., Adiego, B., Mendoza, M., Molina, F. S., Carrillo, M. P., Delgado, J. L., Wright, A., Santacruz, B., and Gil, M. M.
- Subjects
MEDICAL screening ,PLACENTAL growth factor ,PREECLAMPSIA ,PREGNANCY outcomes ,OBSTETRICS - Abstract
Objective: To evaluate the diagnostic accuracy of the Fetal Medicine Foundation (FMF) competing‐risks model, incorporating maternal characteristics, mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI) and placental growth factor (PlGF) (the 'triple test'), for the prediction at 11–13 weeks' gestation of preterm pre‐eclampsia (PE) in a Spanish population. Methods: This was a prospective cohort study performed in eight fetal medicine units in five different regions of Spain between September 2017 and December 2019. All pregnant women with a singleton pregnancy and a non‐malformed live fetus attending a routine ultrasound examination at 11 + 0 to 13 + 6 weeks' gestation were invited to participate. Maternal demographic characteristics and medical history were recorded and MAP, UtA‐PI, serum PlGF and pregnancy‐associated plasma protein‐A (PAPP‐A) were measured following standardized protocols. Treatment with aspirin during pregnancy was also recorded. Raw values of biomarkers were converted into multiples of the median (MoM), and audits were performed periodically to provide regular feedback to operators and laboratories. Patient‐specific risks for term and preterm PE were calculated according to the FMF competing‐risks model, blinded to pregnancy outcome. The performance of screening for PE, taking into account aspirin use, was assessed by calculating the area under the receiver‐operating‐characteristics curve (AUC) and detection rate (DR) at a 10% fixed screen‐positive rate (SPR). Risk calibration of the model was assessed. Results: The study population comprised 10 110 singleton pregnancies, including 72 (0.7%) that developed preterm PE. In the preterm PE group, compared to those without PE, median MAP MoM and UtA‐PI MoM were significantly higher, and median serum PlGF MoM and PAPP‐A MoM were significantly lower. In women with PE, the deviation from normal in all biomarkers was inversely related to gestational age at delivery. Screening for preterm PE by a combination of maternal characteristics and medical history with MAP, UtA‐PI and PlGF had a DR, at 10% SPR, of 72.7% (95% CI, 62.9–82.6%). An alternative strategy of replacing PlGF with PAPP‐A in the triple test was associated with poorer screening performance for preterm PE, giving a DR of 66.5% (95% CI, 55.8–77.2%). The calibration plot showed good agreement between predicted risk and observed incidence of preterm PE, with a slope of 0.983 (95% CI, 0.846–1.120) and an intercept of 0.154 (95% CI, −0.091 to 0.397). Conclusions: The FMF model is effective in predicting preterm PE in the Spanish population at 11–13 weeks' gestation. This method of screening is feasible to implement in routine clinical practice, but it should be accompanied by a robust audit and monitoring system, in order to maintain high‐quality screening. © 2023 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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8. Non‐visualization of choroid plexus of fourth ventricle as first‐trimester predictor of posterior fossa anomalies and chromosomal defects
- Author
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Martinez‐Ten, P., Illescas, T., Adiego, B., Estevez, M., Bermejo, C., Wong, A. E., and Sepulveda, W.
- Published
- 2018
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9. Is Rotavirus Contributing to an Increase of Diarrhoea in a Region of Spain?
- Author
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Gerstel, L., Rodrigo, M. P., Adiego, B., Luquero, F. J., Revillo, M. J., Castillo, F. J., Barrasa, A., and Valenciano, M.
- Published
- 2009
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10. TRANSLUCENCIA NUCAL AUMENTADA Y CARIOTIPO NORMAL
- Author
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Tamara lllescas M, Javier Pérez P, Pilar Martínez T, Belén Santacruz M, Begoña Adiego B, and Esther Barrón A
- Subjects
Translucencia nucal ,malformación fetal ,cariotipo normal ,Nuchal translucency ,fetal malformation ,normal karyotype ,Gynecology and obstetrics ,RG1-991 - Abstract
Antecedentes: La exploración ecográfica entre las semanas 11 y 14 tiene un papel fundamental en el cribado de anomalías cromosómicas, siendo la medida de la translucencia nucal un método bien establecido y ampliamente aceptado para este fin. Objetivo: Evaluar retrospectivamente la evolución de los fetos con translucencia nucal aumentada y cariotipo normal. Método: Se recogieron los datos de 104 fetos con TN >percentil 95 (p95) entre las semanas 11 y 14, evaluados en nuestro centro. En los 61 que resultaron eu-ploides, se estudió la incidencia de anomalías estructurales diagnosticadas tanto prenatalmente como tras el nacimiento, así como las pérdidas fetales anteparto. De estos fetos, nacieron sanos el 80% cuando la TN estaba entre p95 y 3,4 mm, el 50% con TN entre 3,5 y 4,4 mm, el 30% con TN entre 4,5 y 5,4 mm, y el 18% con TN > 5,5 mm. Entre los 4 recién nacidos euploides con patología, hubo 3 con cardiopatía. Conclusión: La presencia de TN aumentada entre las 11 -14 semanas en fetos euploides se asocia a un incremento del riesgo de anomalías estructurales mayores, principalmente cardiacas. La prevalencia de malformaciones aumenta significativamente con TN >3,5 mm, y el pronóstico gestacional adverso empeora conforme aumenta la medida de la TN.Background: Ultrasound scan has a main role at the 11-14 weeks screening for chromosomal abnormalities. The measurement of nuchal translucency (NT) thickness is a widespread stablished method to achieve this target. Objective: To assess retrospectively the outcome of fetuses with increased nuchal translucency and normal karyotype. Method: Data were collected from 104 fetuses with NT > 95th percentile at 11 to 14 weeks of gestation, followed in our institution. The sixty one euploid fetuses were studied in order to determine the incidence of structural abnormalities, diagnosed either before or after delivery, as well as antenatal fetal loss. Among these fetuses, there were no malformations at birth in 80% for NT between the 95th percentile and 3.4 mm; 50% for NT between 3.5 and 4.4 mm; 30% for NT of 4.5-5.4 mm; and 18% for NT > 5.5 mm. There were 4 euploid newborns with some kind of structural defect at birth, 3 of them presented a cardiac malformation. Conclusion: The presence of increased NT at 11-14 weeks scan in euploid fetuses it's associated with a higher risk of major structural abnormalities, mainly cardiac ones. The prevalence of malformations is significantly increased for NT > 3.5 mm, and the adverse perinatal outcome is directly associated with the thickness of NT.
- Published
- 2010
11. First-trimester assessment of nasal bone using retronasal triangle view: a prospective study
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Adiego, B., Martinez-Ten, P., Illescas, T., Bermejo, C., and Sepulveda, W.
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- 2014
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12. First-trimester diagnosis of cleft lip and palate using three-dimensional ultrasound
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MARTINEZ-TEN, P., ADIEGO, B., ILLESCAS, T., BERMEJO, C., WONG, A. E., and SEPULVEDA, W.
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- 2012
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13. Three-dimensional ultrasound diagnosis of cleft palate: ‘reverse face’, ‘flipped face’ or ‘oblique face’–which method is best?
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Martínez Ten, P., Pérez Pedregosa, J., Santacruz, B., Adiego, B., Barrón, E., and Sepúlveda, W.
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- 2009
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14. Modelling and Formal Verification of Timing Aspects in Large PLC Programs
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Fernandez Adiego, B, Darvas, D, Blanco Vinuela, E, Tournier, J-C, Gonzalez Suarez, V M, and Blech, J O
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Engineering ,Accelerators and Storage Rings - Abstract
One of the main obstacle that prevents model checking from being widely used in industrial control systems is the complexity of building formal models out of PLC programs, especially when timing aspects need to be integrated. This paper brings an answer to this obstacle by proposing a methodology to model and verify timing aspects of PLC programs. Two approaches are proposed to allow the users to balance the trade-off between the complexity of the model, i.e. its number of states, and the set of specifications possible to be verified. A tool supporting the methodology which allows to produce models for different model checkers directly from PLC programs has been developed. Verification of timing aspects for real-life PLC programs are presented in this paper using NuSMV.
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- 2014
15. Automated Generation of Formal Models from ST Control Programs for Verification Purposes
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Fernandez Adiego, B, Darvas, D, Tournier, J-C, Blanco Vinuela, E, Blech, J-O, and Gonzalez Suarez, V
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Accelerators and Storage Rings - Abstract
In large industrial control systems such as the ones installed at CERN, one of the main issues is the ability to verify the correct behaviour of the Programmable Logic Controller (PLC) programs. While manual and automated testing can achieve good results, some obvious problems remain unsolved such as the difficulty to check safety or liveness properties. This paper proposes a general methodology and a tool to verify PLC programs by automatically generating formal models for different model checkers out of ST code. The proposed methodology defines an automata-based formalism used as intermediate model (IM) to transform PLC programs written in ST language into different formal models for verification purposes. A tool based on Xtext has been implemented that automatically generates models for the NuSMV and UPPAAL model checkers and the BIP framework.
- Published
- 2014
16. Transforming PLC Programs into Formal Models for Verification Purposes
- Author
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Darvas, D, Fernandez Adiego, B, and Blanco, E
- Subjects
Accelerators and Storage Rings - Abstract
Most of CERN’s industrial installations rely on PLC-based (Programmable Logic Controller) control systems developed using the UNICOS framework. This framework contains common, reusable program modules and their correctness is a high priority. Testing is already applied to find errors, but this method has limitations. In this work an approach is proposed to transform automatically PLC programs into formal models, with the goal of applying formal verification to ensure their correctness. We target model checking which is a precise, mathematical-based method to check formalized requirements automatically against the system.
- Published
- 2013
17. Caso de Rabia canina importada de Marruecos a España. Junio de 2013
- Author
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Suarez-Rodriguez, Berta, Santos, S., Sánchez-Gómez, A., Saravia, G., Sierra, M.J., Amela, Carmen, Gutierrez, G, Jané, M., Adiego, B, Lopaz, Maria Ángeles, Sáez, Jose Luís, García Villacieros, Elena, Echevarria, Juan Emilio, Rodriguez Valin, Elena, and Simón, F.
- Abstract
El 5 de junio de 2013, el servicio de epidemiología de Castilla-La Mancha notificó al Centro de Coordinación de Alertas y Emergencias Sanitarias (CCAES) un caso confirmado de rabia en un perro abatido por la policía en la ciudad de Toledo el 1 de junio. El animal había mordido a cuatro niños y un adulto. Uno de los niños requirió hospitalización e ingresó en la Unidad de Cuidados Intensivos. El Laboratorio Nacional de Referencia para lyssavirus realizó el diagnóstico por inmunofluorescencia, PCR y cultivo celular, así como la secuenciación genómica de la cepa del virus y su comparación con las cepas circulantes en países endémicos. Inmediatamente tras conocerse los resultados, los cuatro niños y el adulto recibieron profilaxis post-exposición con vacuna e inmunoglobulina. Las investigaciones preliminares revelaron que el perro había viajado con sus dueños el 22 de mayo desde Cataluña a una pequeña localidad a 10 km de Toledo. Según los dueños, el perro había escapado unos días antes de ser localizado en Toledo. En ese momento existía la sospecha, aún sin confirmar, de que el perro hubiera estado unos meses antes en Marruecos. España (territorio peninsular, Islas Baleares y Canarias) ha estado libre de rabia terrestre desde 1978. Tras recibir la notificación y según lo establecido en el Plan de Contingencia para el control de la rabia en España, se constituyó una comisión técnica formada por representantes de la Dirección General de Salud Pública, Calidad e Innovación del Ministerio de Sanidad, Servicios Sociales e Igualdad (DGSPCI), la Dirección General de Sanidad de la Producción Agrícola y Ganadera del Ministerio de Agricultura, Alimentación y Medio Ambiente (DGSPA), las Comunidades Autónomas afectadas, el Laboratorio Nacional de Referencia de rabia y el Centro Nacional de Epidemiología (CNE). Los objetivos de esta comisión eran coordinar la investigación del suceso, evaluar el riesgo para la salud humana y animal, proponer la activación de los correspondientes niveles de alerta y coordinar la aplicación de las medidas de control apropiadas. No
- Published
- 2013
18. UNICOS Evolution: CPC Version 6
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Blanco Vinuela, E, Beckers, J M, Bradu, B, Durand, Ph, Fernandez Adiego, B, Izquierdo Rosas, S, Merezhin, A, Ortola Vidal, J, Rochez, J, and Willeman, D
- Subjects
Accelerators and Storage Rings - Abstract
The UNICOS (UNified Industrial COntrol System) framework was created back in 1998. Since then a noticeable number of applications in different domains have used this framework. Furthermore UNICOS has been formalized and its supervision layer has been reused in other kinds of applications (e.g. monitoring or supervisory tasks) where a control layer is not necessarily UNICOS oriented. The process control package has been reformulated as the UNICOS CPC package (Continuous Process Control) and a reengineering process has been followed. The drive behind these noticeable changes was (1) being able to upgrade to the new more performing IT technologies in the automatic code generation, (2) being flexible enough to create new additional device types to cope with other needs (e.g. Vacuum or Cooling and Ventilation applications) without major impact on the framework or the PLC code baselines and (3) enhance the framework with new functionalities (e.g. recipes). This publication addresses the motivation, changes, new functionalities and results obtained. It introduces in an overall view the technologies used and changes followed, emphasizing what has been gained for the developer and the final user. Finally some of the new domains where UNICOS CPC has been used will be illustrated.
- Published
- 2011
19. UNICOS CPC6: Automated Code Generation for Process Control Applications
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Fernandez Adiego, B, Blanco Vinuela, E, and Prieto Barreiro, I
- Subjects
Accelerators and Storage Rings - Abstract
The Continuous Process Control package (CPC) is one of the components of the CERN Unified Industrial Control System framework (UNICOS) [1]. As a part of this framework, UNICOS-CPC provides a well defined library of device types, amethodology and a set of tools to design and implement industrial control applications. The new CPC version uses the software factory UNICOS Application Builder (UAB) [2] to develop CPC applications. The CPC component is composed of several platform oriented plugins PLCs and SCADA) describing the structure and the format of the generated code. It uses a resource package where both, the library of device types and the generated file syntax, are defined. The UAB core is the generic part of this software, it discovers and calls dynamically the different plug-ins and provides the required common services. In this paper the UNICOS CPC6 package is introduced. It is composed of several plug-ins: the Instance generator and the Logic generator for both, Siemens and Schneider PLCs, the SCADA generator (based on PVSS) and the CPC wizard as a dedicated plug-in created to provide the user a friendly GUI. A tool called UAB Bootstrap will manage the different UAB components, like CPC, and its dependencies with the resource packages. This tool guides the control system developer during the installation, update and execution of the UAB components.
- Published
- 2011
20. Model Oriented Application Generation for Industrial Control Systems
- Author
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Copy, B, Barillere, R, Blanco Vinuela, E, Fernandez Adiego, B, Nogueira Ferandes, R, and Prieto Barreiro, I
- Subjects
ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Accelerators and Storage Rings - Abstract
The CERN Unified Industrial Control Systems framework (UNICOS) is a software generation methodology and a collection of development tools that standardizes the design of industrial control applications [1]. A Software Factory, named the UNICOS Application Builder (UAB) [2], was introduced to ease extensibility and maintenance of the framework, introducing a stable metamodel, a set of platformindependent models and platformspecific configurations against which code generation plugins and configuration generation plugins can be written. Such plugins currently target PLC programming environments (Schneider and SIEMENS PLCs) as well as SIEMENS WinCC Open Architecture SCADA (previously known as ETM PVSS) but are being expanded to cover more and more aspects of process control systems. We present what constitutes the UNICOS metamodel and the models in use, how these models can be used to capture knowledge about industrial control systems and how this knowledge can be leveraged to generate both code and configuration for a variety of target usages.
- Published
- 2011
21. TRANSLUCENCIA NUCAL AUMENTADA Y CARIOTIPO NORMAL
- Author
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Belén Santacruz M, Begoña Adiego B, Javier Pérez P, Esther Barrón A, Pilar Martínez T, and Tamara lllescas M
- Subjects
normal karyotype ,Nuchal translucency ,Obstetrics and Gynecology ,Translucencia nucal ,cariotipo normal ,malformación fetal ,fetal malformation - Abstract
Antecedentes: La exploración ecográfica entre las semanas 11 y 14 tiene un papel fundamental en el cribado de anomalías cromosómicas, siendo la medida de la translucencia nucal un método bien establecido y ampliamente aceptado para este fin. Objetivo: Evaluar retrospectivamente la evolución de los fetos con translucencia nucal aumentada y cariotipo normal. Método: Se recogieron los datos de 104 fetos con TN >percentil 95 (p95) entre las semanas 11 y 14, evaluados en nuestro centro. En los 61 que resultaron eu-ploides, se estudió la incidencia de anomalías estructurales diagnosticadas tanto prenatalmente como tras el nacimiento, así como las pérdidas fetales anteparto. De estos fetos, nacieron sanos el 80% cuando la TN estaba entre p95 y 3,4 mm, el 50% con TN entre 3,5 y 4,4 mm, el 30% con TN entre 4,5 y 5,4 mm, y el 18% con TN > 5,5 mm. Entre los 4 recién nacidos euploides con patología, hubo 3 con cardiopatía. Conclusión: La presencia de TN aumentada entre las 11 -14 semanas en fetos euploides se asocia a un incremento del riesgo de anomalías estructurales mayores, principalmente cardiacas. La prevalencia de malformaciones aumenta significativamente con TN >3,5 mm, y el pronóstico gestacional adverso empeora conforme aumenta la medida de la TN. Background: Ultrasound scan has a main role at the 11-14 weeks screening for chromosomal abnormalities. The measurement of nuchal translucency (NT) thickness is a widespread stablished method to achieve this target. Objective: To assess retrospectively the outcome of fetuses with increased nuchal translucency and normal karyotype. Method: Data were collected from 104 fetuses with NT > 95th percentile at 11 to 14 weeks of gestation, followed in our institution. The sixty one euploid fetuses were studied in order to determine the incidence of structural abnormalities, diagnosed either before or after delivery, as well as antenatal fetal loss. Among these fetuses, there were no malformations at birth in 80% for NT between the 95th percentile and 3.4 mm; 50% for NT between 3.5 and 4.4 mm; 30% for NT of 4.5-5.4 mm; and 18% for NT > 5.5 mm. There were 4 euploid newborns with some kind of structural defect at birth, 3 of them presented a cardiac malformation. Conclusion: The presence of increased NT at 11-14 weeks scan in euploid fetuses it's associated with a higher risk of major structural abnormalities, mainly cardiac ones. The prevalence of malformations is significantly increased for NT > 3.5 mm, and the adverse perinatal outcome is directly associated with the thickness of NT.
- Published
- 2010
22. OC24.06: Absence of the choroid plexus of the IV ventricle in the first trimester as a predictor of posterior fossa anomalies and aneuploidies: a 3‐dimensional ultrasound study
- Author
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Martínez‐Ten, P., primary, Illescas, T., additional, Adiego, B., additional, Estévez, M., additional, and Sepulveda, W., additional
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- 2014
- Full Text
- View/download PDF
23. P02.13: Transcervical chorionic villous sampling: experience in a private centre in Spain
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Illescas, T., primary, Adiego, B., additional, and Martínez-Ten, P., additional
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- 2014
- Full Text
- View/download PDF
24. P24.15: Non-visible gallbladder during the second half of pregnancy: case report
- Author
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Illescas, T., primary, Martínez-Ten, P., additional, Adiego, B., additional, Crespo, A., additional, Estévez, M., additional, and Huertas, M., additional
- Published
- 2014
- Full Text
- View/download PDF
25. Three-dimensional ultrasound diagnosis of cleft palate: 'reverse face', 'flipped face' or 'oblique face'--which method is best?
- Author
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Ten PM, Perez Pedregosa J, Santacruz B, Adiego B, Barrón E, Sepúlveda W, Martínez Ten, P, Pérez Pedregosa, J, Santacruz, B, Adiego, B, Barrón, E, and Sepúlveda, W
- Abstract
Objectives: To compare the performance of three sonographic techniques, the 'reverse-face', 'flipped-face' and 'oblique-face' methods, for visualizing the hard and soft palate in diagnosing cleft lip and palate (CLP).Methods: A total of 60 fetuses (10 with CLP) with a gestational age ranging from 20 to 33 weeks were examined. We compared visualization of the secondary palate with the previously described reverse-face and flipped-face methods (the latter modified by us) and the oblique-face method developed by us using Oblique View imaging technology.Results: Among the 10 fetuses with CLP the defect involved the lip, alveolus and secondary palate in seven, and the primary palate only in the remaining three. The upper lip and alveolar ridge were well visualized in all cases with all three methods. Involvement of the hard palate was diagnosed correctly in 71% (5/7) of the cases using the reverse-face view, in 86% (6/7) with the flipped-face view, and in 100% (7/7) with the oblique-face view; the hard palate was correctly found to be intact in 78%, 84% and 86%, respectively, of the 50 normal fetuses examined with each view. Involvement of the soft palate was diagnosed correctly in only one of the seven fetuses with defects of the secondary palate in flipped-face and oblique-face views, and was correctly considered intact in only 16% of normal fetuses in flipped-face view and in 26% in oblique-face images.Conclusions: Accurate visualization of the soft palate requires an excellent initially acquired volume, fluid between the fetal tongue and palate, and curving of the plane to follow the structure of the palate. The oblique-face or flipped-face views make it possible to visualize the soft palate well in selected cases. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
26. P13.03: Transabdominal assessment of the mid-sagittal plane of the fetal brain: comparison between two- and three-dimensional ultrasound
- Author
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Illescas, T., primary, Martínez-Ten, P., additional, Adiego, B., additional, Bermejo, C., additional, Gómez, M., additional, and Sepulveda, W., additional
- Published
- 2012
- Full Text
- View/download PDF
27. OC08.01: Diagnosis of fetal orofacial clefts in the first trimester: a three‐dimensional (3D) ultrasound study
- Author
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Martinez‐Ten, P., primary, Adiego, B., additional, Illescas, T., additional, Bermejo, C., additional, Wong, A. E., additional, and Sepulveda, W., additional
- Published
- 2011
- Full Text
- View/download PDF
28. OC08.01:.
- Author
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Martinez-Ten, P., Adiego, B., Illescas, T., Bermejo, C., Wong, A. E., and Sepulveda, W.
- Subjects
- *
CLEFT palate , *FIRST trimester of pregnancy ,ABSTRACTS - Abstract
An abstract of the article "Diagnosis of fetal orofacial clefts in the first trimester: a three-dimensional (3D) ultrasound study," by P. Martinez-Ten and colleagues is presented.
- Published
- 2011
- Full Text
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29. Prenatal screening and diagnosis of genetic abnormalities: SEGO, SEQC ML , AEDP consensus recommendations.
- Author
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Prieto B, Adiego B, Suela J, Martín I, Santacruz B, García-Planells J, Gil M, González C, and Eva Barrenechea
- Abstract
In this paper, the scientific societies SEGO, SEQC
ML and AEDP provide a series of consensus-based recommendations for prenatal screening and diagnosis of genetic abnormalities. A set of evaluation indicators are also proposed as a means to improve the quality of the biochemical, ultrasound, and genetic processes involved in prenatal screening and diagnosis of genetic anomalies. Some recommendations are also proposed in relation to invasive prenatal diagnostic procedures, more specifically regarding sample collection and genetic testing. The purpose of this proposal is to unify performance criteria and quality indicators at national level, with audits performed on a regular basis. It is strongly recommended that a national prenatal screening strategy be established and provided with the resources necessary to evaluate the performance of quality indicators and diagnostic procedures under the supervision of health authorities. Protocols should be revised on a regular basis to consider the incorporation of new cost-effective technologies., Competing Interests: Competing interests: Authors state no conflict of interest., (© 2020 Belén Prieto et al., published by De Gruyter, Berlin/Boston.)- Published
- 2020
- Full Text
- View/download PDF
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