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Submitted by phemiran@stj.jus.br (phemiran@stj.jus.br) on 2022-05-09T18:32:34Z No. of bitstreams: 2 direito_financeiro_faculdades_abraham.pdf: 1432124 bytes, checksum: 6897f0ab1900e627ad8719493e4ee153 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2022-05-19T00:44:34Z (GMT) No. of bitstreams: 2 direito_financeiro_faculdades_abraham.pdf: 1432124 bytes, checksum: 6897f0ab1900e627ad8719493e4ee153 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2022-05-19T00:44:34Z (GMT). No. of bitstreams: 2 direito_financeiro_faculdades_abraham.pdf: 1432124 bytes, checksum: 6897f0ab1900e627ad8719493e4ee153 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2022

Introduction: Diabetes mellitus is regarded as a pro-thrombotic state1. Extreme hyperglycemia and dehydration in the hyperglycemic hyperosmolar state (HHS) add to the risk for thrombo-ischemic events2,3. Lower limb ischemia and occlusion of the femoral arteries in HHS is a distinct association, but its development may be hard to recognize due to its infrequent occurrence in daily practice. Prompt recognition is important to prevent irreversible damage3,4,5. Case Presentation: A 50-year old female was admitted to the intensive care unit (ICU) with epigastric pain for 1 day. She reported no other medical conditions except hypertension. Clinical examination showed a fully conscious female who was severely dehydrated. Clinical and laboratory parameters on admission are represented in Table 1. Based on a glucose level >30 mmol/L and an osmolarity >320 mOsm/L, HHS was diagnosed. Other investigations (septic work up, chest X ray, and ECG) were normal. The patient received a total of 9 liters of 0.9% saline with insulin/potassium over 6 hours. Dalteparin was given subcutaneously (5000 IU daily). On the second day of admission signs of acute ischemia were noticed in the left upper and left lower limbs. An ultrasound doppler and CT angiography confirmed the occlusion of the left subclavian, left femoral artery and aortic arch thrombosis (Figures 1A). Echocardiography showed a thrombus in the aortic arch. An emergency thrombectomy of the brachial and femoral arteries and a left arm fasciotomy took place and therapeutic unfractionated heparin infusion was started. A thrombophilia work up for antiphospholipid syndrome, heparin induced thrombocytopenia, complements 3 and 5, antinuclear antibody (ANCA), lupus screen, homocysteine, antithrombin, Factor V leiden, anticardiolipin, anti-B2 glycoprotein, protein S and C activity were normal. The patient and the family denied a personal or family history of thromboembolic events. On the fifth day post-admission, the patient developed septic shock with multi-organ failure (circulatory, respiratory, renal, and coagulation). The patient responded to ICU management. Parameters of her coagulation profile are given in Table 1. On the ninth day the patient developed dry gangrene in the left foot, which required a below the knee amputation. On the eleventh day the patient was extubated, neurological assessment was showing right-sided hemiparesis. The MRI was showing multiple microcerebral hemorrhages, an infarction in the left paramedian pons and a cerebellar infarction (Figures 1B). On the fourteenth day the patient developed abdominal distension. The CT showed partial mesenteric vein thrombosis despite the patient being on therapeutic heparin (Figure 2). On the seventeenth day the patient had a tracheostomy and was discharged from the ICU for rehabilitation on a therapeutic dose of dalteparin. Conclusion: Current guidelines provide for thromboprophylaxis in HHS, i.e., heparin during admission. This covers the risk for deep venous thrombosis (DVT), but might be insufficient in case of an imminent arterial thrombosis, especially in cases of long existing diabetes. Alternative therapy targeting crucial factors in the coagulation pathway leading to an arterial thrombus should be searched. The development of an algorithm for thromboprophylaxis in a hyperglycemic crisis needs our attention to improve the outcome of this high-risk condition.

Submitted by Maria Fernanda Leite (leitem@stj.jus.br) on 2020-10-15T22:12:17Z No. of bitstreams: 2 covid_respostas_direito_abraham.pdf: 336239 bytes, checksum: ba1556e2e92bef86ec863dffb08ccb95 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2020-10-16T19:17:46Z (GMT) No. of bitstreams: 2 covid_respostas_direito_abraham.pdf: 336239 bytes, checksum: ba1556e2e92bef86ec863dffb08ccb95 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2020-10-16T19:17:46Z (GMT). No. of bitstreams: 2 covid_respostas_direito_abraham.pdf: 336239 bytes, checksum: ba1556e2e92bef86ec863dffb08ccb95 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2020

Submitted by tgoncalv@stj.jus.br (tgoncalv@stj.jus.br) on 2020-06-15T17:46:47Z No. of bitstreams: 2 negocio_juridico_processual_abraham.pdf: 196169 bytes, checksum: c74e907ed2b0efc0393933cc7d18634d (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2020-06-15T22:31:32Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) negocio_juridico_processual_abraham.pdf: 196169 bytes, checksum: c74e907ed2b0efc0393933cc7d18634d (MD5) Made available in DSpace on 2020-06-15T22:31:33Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) negocio_juridico_processual_abraham.pdf: 196169 bytes, checksum: c74e907ed2b0efc0393933cc7d18634d (MD5) Previous issue date: 2020

Submitted by Maria Fernanda Leite (leitem@stj.jus.br) on 2021-01-27T19:41:16Z No. of bitstreams: 2 eficiencia_processual_recuperalidade_abraham.pdf: 591478 bytes, checksum: 974cb616912f661dadba996f2ed7577c (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2021-02-22T11:39:28Z (GMT) No. of bitstreams: 2 eficiencia_processual_recuperalidade_abraham.pdf: 591478 bytes, checksum: 974cb616912f661dadba996f2ed7577c (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2021-02-22T11:39:28Z (GMT). No. of bitstreams: 2 eficiencia_processual_recuperalidade_abraham.pdf: 591478 bytes, checksum: 974cb616912f661dadba996f2ed7577c (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2019

Submitted by Iury Batista (iurys@stj.jus.br) on 2019-06-26T19:01:51Z No. of bitstreams: 2 plano_equilibrio_fiscal_abraham.pdf: 99082 bytes, checksum: b5f3fe5406e548d50ddb80a569be6fad (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2019-06-27T15:51:31Z (GMT) No. of bitstreams: 2 plano_equilibrio_fiscal_abraham.pdf: 99082 bytes, checksum: b5f3fe5406e548d50ddb80a569be6fad (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2019-06-27T15:51:31Z (GMT). No. of bitstreams: 2 plano_equilibrio_fiscal_abraham.pdf: 99082 bytes, checksum: b5f3fe5406e548d50ddb80a569be6fad (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2019

Submitted by rafaelrn@stj.jus.br (rafaelrn@stj.jus.br) on 2020-01-22T16:30:20Z No. of bitstreams: 2 consideracoes_sobre_propostas_abraham.pdf: 131843 bytes, checksum: dff3f651c86378f956dc6dfdb56862b5 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Roberta Marins (rmarins@stj.jus.br) on 2020-01-22T20:44:44Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) consideracoes_sobre_propostas_abraham.pdf: 131843 bytes, checksum: dff3f651c86378f956dc6dfdb56862b5 (MD5) Made available in DSpace on 2020-01-22T20:44:44Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) consideracoes_sobre_propostas_abraham.pdf: 131843 bytes, checksum: dff3f651c86378f956dc6dfdb56862b5 (MD5) Previous issue date: 2019

Contains fulltext : 172582.pdf (Publisher’s version ) (Open Access) Objective Postpartum hemorrhage (PPH) has a continuously rising incidence worldwide, suggesting suboptimal care. An important step in optimizing care is the translation of evidence-based guidelines into comprehensive hospital protocols. However, knowledge about the quality of these protocols is lacking. The objective of this study was to evaluate the quality of PPH-protocols on structure and content in the Netherlands. Methods We performed an observational multicenter study. Eighteen PPH-protocols from 3 University Hospitals (UH), 8 Teaching Hospitals (TH) and 7 Non-Teaching hospitals (NTH) throughout the Netherlands were acquired. The structure of the PPH-protocols was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE-II) Instrument. The content was appraised using previously developed quality indicators, based on international guidelines and Advance-Trauma-Life-Support (ATLS)-based course instructions. Results The quality of the protocols for postpartum hemorrhage for both structure and content varied widely between different hospitals, but all of them showed room for improvement. The protocols scored mainly below average on the different items of the AGREE-II instrument (8 of the 10 items scored

Submitted by Iury Batista (iurys@stj.jus.br) on 2018-09-10T17:14:26Z No. of bitstreams: 2 valores_principios_licoes_abraham.pdf: 141197 bytes, checksum: 59a5b3da9a248fa6b6cfc22c8d90f341 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Roberta Marins (rmarins@stj.jus.br) on 2018-09-10T20:59:23Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) valores_principios_licoes_abraham.pdf: 141197 bytes, checksum: 59a5b3da9a248fa6b6cfc22c8d90f341 (MD5) Made available in DSpace on 2018-09-10T20:59:24Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) valores_principios_licoes_abraham.pdf: 141197 bytes, checksum: 59a5b3da9a248fa6b6cfc22c8d90f341 (MD5) Previous issue date: 2018

Thrombus formation was measured by the viscoelastic test: ROTEM (Tem International GmbH c/o Dutch Affiliate, Tilburg, The Netherlands). Standard assays were used according to the manufac- turer’s recommendations: EXTEM (ref.: 503-05, Tem International GmbH c/o Dutch Affiliate, Til- burg, The Netherlands), FIBTEM (ref.: 503-06, Tem International GmbH c/o Dutch Affiliate, Til- burg, The Netherlands), and HEPTEM (ref.: 503-09, Tem International GmbH c/o Dutch Affiliate, Tilburg, The Netherlands). All samples were measured within 1 h after blood collection. Further- more, by means of EXTEM and FIBTEM results, the contribution of platelet count to the thrombus formation was calculated as the PLTEM parameter [22].

Platelet activation was quantitatively assessed on a randomly selected subgroup of 10 patients (not treated with acetylsalicylic acid) in un-processed blood by the PACT (Platelet activation test, adjusted from Roest 2013). In the original paper, Roest performs the tests at room temperature while in this manuscript, the PACT test is performed at 37°C which requires higher agonist doses. The PACT is based on platelet activation induced by addition of a specific agonist to whole blood and gives specific insight in the granule release capacity and in the aggregation potential of platelets. The test contains three agonists to activate the platelets: (1) the protease activated receptor (PAR-1) agonist thrombin receptor activator peptide (TRAP f.c. 30 μM, SFLLRN, H-2936; Bachem, Germany), (2) the glycoprotein VI (GPVI) agonist collagen-related peptide (CRP f.c. 5 μg/ml, Pro- fessor Farndale, university of Cambridge, UK), and (3) the P2Y12 agonist ADP (f.c. 30 μM, 01897, Sigma-Aldrich, Zwijndrecht, the Netherlands) in HEPES-buffered saline (HBS, 10 mmol/L HEPES, 150 mmol/L NaCl, 1 mmol/L MgSO4, 5 mmol/L KCL, pH 7.4). The reaction mixtures also contain three antibodies directed against GPIb (APC-conjugated CD42b, BD Bioscience), activated αIIbβ3 (FITC-conjugated PAC-1) and P-selectin (PE-conjugated CD62P) purchased from BD Pharmingen (Franklin Lakes, USA). Whole blood was heated at 37°C for 10 min and the tests were performed at 37°C. Whole blood was diluted 1:4 in HEPES-buffered saline and 5 μl of this diluted blood was added to each reaction mixture. Reactions were stopped by adding 250 μl fixation solution (137 mmol/L NaCl, 2.7 mmol/L KCl, 1.12 mmol/L NaH2PO4, 1.15 mmol/L KH2PO4, 10.2 mmol/L Na2HPO4, 4 mmol/L EDTA, 0.5% formaldehyde) after exactly 20 min of incubation at 37°C. Flow cytometry was used to distinguish between platelets and other cells on forward and sideward scatter pattern and by gating on the CD42b positive cells. Fluorescent intensity in the FITC gate and PE gate was selected to determine activated αIIbβ3 and P-selectin density, respectively, and results are expressed as median fluorescent intensity (MFI).

TG in plasma was measured with the calibrated automated thrombogram (CAT) assay as developed by Hemker and co-workers [18-20]. Briefly, 80 μl platelet poor plasma (PPP) was mixed with 20 μl of a mixture containing tissue factor (Dade-Behring) at a final concentration of 1 pM and phospholipid vesicles (f.c. 4 μM 20 mol% phosphatidylserine, 60 mol% phosphatidylcholine and 20 mol% phosphatidyl-ethanolamine, Avanti). To calibrator wells, 20 μl of calibrator (α2macroglobulin- thrombin complex, [19]) was added instead of TF and PL. After 10 minutes of incubation at 37°C, thrombin generation was initiated by the addition of 20 μl of the thrombin specific substrate, Z- Gly-Gly-Arg-7-amino-4-methylcoumarin (f.c. 416 μM, Bachem) and CaCl2 (f.c. 16.7 mM). Fluorescence was measured with a Fluoroscan Ascent reader (Thermo Labsystems) and data were analyzed with dedicated software (Thrombinoscope, Stago) [20]. Thrombin generation was expressed based on endogenous thrombin potential (ETP); lagtime (LT); thrombin peak (TP), time-to-thrombin peak (TTP).

Standard hematological analyses EDTA-anticoagulated blood was used for cytometric analysis using a whole blood counter Sysmex XE 2100® (Sysmex,Kobe, Japan) to obtain a whole blood count. Fibrinogen levels were determined with an ACL-9000 (Diamond Diagnostics, Holliston, MA) coagulation analyser, using a PT-fibrinogen high sensitivity reagent, which is a high-sensitivity calcium thromboplastin that allows the simultaneous determination of PT and fibrinogen levels. aPTT was measured using an ACL-9000 coagulation analyser and INR was calculated by the formula INR (PT patient/PT normal).

Texto de autoria de Ministro do Superior Tribunal de Justiça. Submitted by Tiago Carvalho (tiagosc@stj.jus.br) on 2017-09-28T13:42:26Z No. of bitstreams: 2 prefacio_lei_responsabilidade_salomao.pdf: 435902 bytes, checksum: 3f77a1610f1379a32b185cb0a6ac6bdf (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Patrícia Rabello (rabello@stj.jus.br) on 2017-10-23T17:36:45Z (GMT) No. of bitstreams: 2 prefacio_lei_responsabilidade_salomao.pdf: 435902 bytes, checksum: 3f77a1610f1379a32b185cb0a6ac6bdf (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2017-10-23T17:36:45Z (GMT). No. of bitstreams: 2 prefacio_lei_responsabilidade_salomao.pdf: 435902 bytes, checksum: 3f77a1610f1379a32b185cb0a6ac6bdf (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2017

Submitted by Patrícia Rabello (rabello@stj.jus.br) on 2018-02-27T18:12:32Z No. of bitstreams: 2 etica_confianca_legitima_abraham.pdf: 138054 bytes, checksum: cc07ed83b05059d66b440a7465694791 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Roberta Marins (rmarins@stj.jus.br) on 2018-02-28T19:41:46Z (GMT) No. of bitstreams: 2 etica_confianca_legitima_abraham.pdf: 138054 bytes, checksum: cc07ed83b05059d66b440a7465694791 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2018-02-28T19:41:46Z (GMT). No. of bitstreams: 2 etica_confianca_legitima_abraham.pdf: 138054 bytes, checksum: cc07ed83b05059d66b440a7465694791 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2017

GOMES, Marcus Lívio; ABRAHAM, Marcus; PEREIRA, Vítor Pimentel. O sigilo bancário e a privacidade do cidadão: alguns aspectos da jurisprudência do STF. NOMOS - Revista do Programa de Pós-Graduação em Direito da Universidade Federal do Ceará, Fortaleza, v.36, n.1, p. 331-349, jan./jun., 2016. This article addresses the issue of banking secrecy in the judicial precedents of the Brazil ian Supreme Court, demonstrating how the constitutionally qualified conflict of interests between privacy of citizens and fundamental duty to pay taxes has been settled by the Supreme Court in different ways over the years, especially with the recent Court decision allowing access by tax thorities (without previous judicial authorization) to taxpayers' bank dat O presente artigo aborda o tema do sigilo bancário na jurisprudência do Supremo Tribu nal Federal, demonstrando como o conflito de interesses constitucionalmente qualificado entre privacidade dos cidadãos e dever fundamental de pagar tributos tem sido resolvido pela Suprema Corte de forma distinta ao longo dos anos, sobretudo com a recente decisão do STF que permite o acesso pelo Fisco, sem prévia autorização judicial, aos dados bancários do contribuinte.

Apresenta pequena ampliação de texto em relação ao artigo publicado sob o título “Os 15 anos da Lei de Responsabilidade Fiscal” na revista Justiça & Cidadania, Rio de Janeiro, v. 17, n. 177, p. 27-31, maio 2015. Submitted by rafaelrn@stj.jus.br (rafaelrn@stj.jus.br) on 2020-01-23T17:26:41Z No. of bitstreams: 2 transparencia_cidadania_fiscal_abraham.pdf: 537900 bytes, checksum: 2d35cc8294b558d78d79f8a786307546 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Roberta Marins (rmarins@stj.jus.br) on 2020-01-27T20:25:13Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) transparencia_cidadania_fiscal_abraham.pdf: 537900 bytes, checksum: 2d35cc8294b558d78d79f8a786307546 (MD5) Made available in DSpace on 2020-01-27T20:25:13Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) transparencia_cidadania_fiscal_abraham.pdf: 537900 bytes, checksum: 2d35cc8294b558d78d79f8a786307546 (MD5) Previous issue date: 2016

ABRAHAM, Marcus; GOMES, Marcus Lívio; PEREIRA, Vítor Pimentel. A execução fiscal de dívida ativa não-tributária e a dissolução irregular da pessoa jurídica. NOMOS: Revista do Programa de Pós-Graduação em Direito da UFC, Fortaleza, v.35, n.1, 2015, p. 255-274. This paper analyses the possibility of redirecting fiscal executory procedures of public active non-tax debt against the company's representative that caused the irregular dissolution of the company. The breach of private law regulation configures sufficient legal cause for the redirecting of the executory procedure against the legal representative, regardless of the application of tax laws. Although the normative basis on the liability of the managing partner may be divergent in the case of public active tax debt or non-tax debt, the same fact (the irregular dissolution) couldn’t be considered illicit in one case and not for another. O presente texto analisa a possibilidade de que a execução fiscal de dívida ativa não-tributária possa ser redirecionada ao sócio-administrador que deu causa à dissolução irregular da sociedade empresária. A violação às normas de direito privado presente na dissolução irregular configura causa jurídica suficiente para o redirecionamento, sem qualquer dependência da aplicação de normas tributárias. Embora os fundamentos normativos para a responsabilização do sócio-administrador sejam diversos caso se trate de dívida ativa tributária ou não-tributária, não poderia um mesmo fato (a dissolução irregular) ser considerado ilícito para um e não para o outro.

Mild therapeutic hypothermia is considered standard care in the treatment of patients resuscitated from cardiac arrest. With increasingly more frequent concomitant use of platelet-inhibiting drugs, clinicians must be cognizant of the ramifications of hypothermia on platelet function as part of hemostasis. The effects of hypothermia on platelet function have been studied for more than 50 years, but the results are inconsistent and may be related to the circumstances during which hypothermia is achieved. This review summarizes current knowledge of platelet function during hypothermia and the impact on hemostasis.

ABRAHAM, Marcus. Common law e os precedentes vinculantes na jurisprudência tributária. NOMOS: Revista do Programa de Pós-Graduação em Direito da UFC, Fortaleza, v.34, n.1, 2014, p.145-167. The paper deals with the rapprochement between the Brazilian legal system and Common Law (Anglo-Saxon legal tradition) in relation to procedural law, especially in the resolution of repetitive litigation, with the adoption of the so-called stare decisis theory as a means to achieve greater promptness and uniformity of case law through the verticalization of Superior Courts' judicial precedents. It also examines the influence of such an approach on Brazilian Tax Law system, especially in the case law of the Brazilian Supreme Federal Court and the Brazilian Superior Court of Justice. O artigo trata da aproximação do direito brasileiro ao sistema jurídico do common law (tradição jurídica anglo-saxã) quanto ao direito processual, especialmente na resolução de demandas repetitivas, com a adoção da chamada teoria dos precedentes como meio para se conseguir maior celeridade processual e uniformização da jurisprudência pela verticalização da jurisprudência dos Tribunais Superiores. Além disso, analisa a influência de tal aproximação sobre o direito tributário nacional, sobretudo na jurisprudência do Supremo Tribunal Federal e do Superior Tribunal de Justiça.

Submitted by Tiago Carvalho (ctscarva@stj.jus.br) on 2016-04-28T17:06:43Z No. of bitstreams: 2 50_anos_lei_abraham.pdf: 139249 bytes, checksum: 81be1335e997fb19568526f5254f2591 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Rafaella Monterei (rcarine@stj.jus.br) on 2016-05-04T19:44:51Z (GMT) No. of bitstreams: 2 50_anos_lei_abraham.pdf: 139249 bytes, checksum: 81be1335e997fb19568526f5254f2591 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2016-05-04T19:44:51Z (GMT). No. of bitstreams: 2 50_anos_lei_abraham.pdf: 139249 bytes, checksum: 81be1335e997fb19568526f5254f2591 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2014

Submitted by Ludmylla Matsuura Correa null (lucorrea@stj.jus.br) on 2014-12-16T19:22:39Z No. of bitstreams: 1 orcamento_publico_direito_abraham.pdf: 817380 bytes, checksum: 40bfc671b3aa1dcb3d8a5ba581a5a114 (MD5) Made available in DSpace on 2014-12-16T19:22:39Z (GMT). No. of bitstreams: 1 orcamento_publico_direito_abraham.pdf: 817380 bytes, checksum: 40bfc671b3aa1dcb3d8a5ba581a5a114 (MD5) Previous issue date: 2014

Submitted by jualmei@stj.jus.br (jualmei@stj.jus.br) on 2021-08-09T15:48:10Z No. of bitstreams: 2 teoria_adimplemento_substancial_abraham.pdf: 632651 bytes, checksum: fd85b50d5c11743e6815326313dbdcdd (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2021-08-09T20:17:09Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) teoria_adimplemento_substancial_abraham.pdf: 632651 bytes, checksum: fd85b50d5c11743e6815326313dbdcdd (MD5) Made available in DSpace on 2021-08-09T20:17:09Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) teoria_adimplemento_substancial_abraham.pdf: 632651 bytes, checksum: fd85b50d5c11743e6815326313dbdcdd (MD5) Previous issue date: 2014

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Platelet function can be quantitatively assessed by specific assays such as light-transmission aggregometry, multiple-electrode aggregometry measuring the response to adenosine diphosphate (ADP), arachidonic acid, collagen, and thrombin-receptor activating peptide and viscoelastic tests such as rotational thromboelastometry (ROTEM). The task of extracting meaningful statistical and clinical information from high-dimensional data spaces in temporal multivariate clinical data represented in multivariate time series is complex. Building insightful visualizations for multivariate time series demands adequate usage of normalization techniques. In this article, various methods for data normalization (z-transformation, range transformation, proportion transformation, and interquartile range) are presented and visualized discussing the most suited approach for platelet function data series. Normalization was calculated per assay (test) for all time points and per time point for all tests. Interquartile range, range transformation, and z-transformation demonstrated the correlation as calculated by the Spearman correlation test, when normalized per assay (test) for all time points. When normalizing per time point for all tests, no correlation could be abstracted from the charts as was the case when using all data as 1 dataset for normalization.

Submitted by Gabriela Evangelista Botelho null (gbotelho@stj.jus.br) on 2014-11-24T17:56:05Z No. of bitstreams: 1 reflexoes_sobre_ec_abraham.pdf: 648625 bytes, checksum: eb306fc9018325dd21d5c88f3b1077d5 (MD5) Made available in DSpace on 2014-11-24T17:56:05Z (GMT). No. of bitstreams: 1 reflexoes_sobre_ec_abraham.pdf: 648625 bytes, checksum: eb306fc9018325dd21d5c88f3b1077d5 (MD5) Previous issue date: 2010

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Submitted by Natalia Cristina Aragao Gomes (ntgomes@stj.jus.br) on 2015-04-24T13:45:21Z No. of bitstreams: 1 responsabilidade_tributaria_socios_abraham.pdf: 651702 bytes, checksum: 6581f1d1e0d62c303aefcdd502a99f91 (MD5) Made available in DSpace on 2015-04-24T13:45:21Z (GMT). No. of bitstreams: 1 responsabilidade_tributaria_socios_abraham.pdf: 651702 bytes, checksum: 6581f1d1e0d62c303aefcdd502a99f91 (MD5) Previous issue date: 2008

Our previous work indicated that suspension-cultured plant cells show remarkable flexibility in altering cell wall structure in response either to growth on saline medium or in the presence of the cellulose synthesis inhibitor 2,-6-dichlorobenzonitrile (DCB). We have continued to analyze the structure of these modified cell walls to understand how the changes modify wall strength, porosity, and ability to expand. The major load-bearing network in the walls of DCB-adapted dicot cells that lack a substantial cellulose-xyloglucan network is comprised of Ca2+-bridged pectates; these cells also have an unusual and abundant soluble pectic fraction. By contrast, DCB-adapted barley, a graminaceous monocot achieves extra wall strength by enhanced cross-linking of its non-cellulosic polysaccharide network via phenolic residues. Our results have also shed new light on normal wall stucture: 1) the cellulose-xyloglucan network may be independent of other wall networks in dicot primary walls and accounts for about 70% of the total wall strength; 2) the pectic network in dicot walls is the primary determinant of wall porosity; 3) both wall strength and porosity in graminaceous monocot primary walls is greatly influenced by the degree of phenolic cross-linking between non-cellulosic polysaccharides; and 4) the fact that the monocot cells do not secrete excess glucuronoarabinoxylan and mixed-linked glucan in response to growth on DCB, suggests that these two non-cellulosic polymers do not normally interact with cellulose in a manner similar to xyloglucan. We also attempted to understand the factors which limit cell expansion during growth of cells in saline medium. Analyses of hydrolytic enzyme activities suggest that xyloglucan metabolism is not repressed during growth on NaCl. Unlike non-adapted cells, salt-adapted cells were found to lack pectin methyl esterase, but it is not clear how this difference could relate to alterations in wall expansibility. Salt-adaped cell walls contain reduced hyp and secrete two unique PRPP-related proteins suggesting that high NaCl inhibits the cross-linking of these proteins into the walls, a finding that might relate to their altered expansibility.

Summary The localization of the cell wall proline-rich proteins (PRPs), and the gene expression of the cell wall glycine-rich proteins (GRPs) and the hydroxyproline-rich glycoproteins (HRGPs) were examined in several dicot species. The PRPs are accumulated in the corner walls of the cortex where several cells are joined together and in the protoxylem cell walls of 3-day-old soybean root. In 1-month-old soybean plants, the PRPs are specifically deposited in xylem vessel elements of the young stem, and they are accumulated in both phloem fibers and xylem vessel elements and fibers of the older stem. Likewise, the PRPs are localized in xylem vessel elements and fibers in tomato, petunia, potato and tobacco stems. They are also found in outer and inner phloem fiber cell walls of tomato stem and in outer phloem fiber cell walls of petunia stem. The gene expression of the HRGPs and the GRPs is develop-mentally regulated in tomato, petunia and tobacco stems. HRGP mRNAs are abundant in outer and inner phloem regions, while GRP mRNAs are present mostly in primary xylem and in the cambium region. Immunocytochemical localization showed that the GRPs have a localization pattern similar to that of the PRPs in tomato, petunia and tobacco stems.

Peptidyl proline hydroxylase inhibitors block the growth of cultured soybean (Glycine max) cells and bring about the disappearance of the major salt-extractable hydroxyproline-rich protein, the 33 kilodalton repetitive proline-rich protein (RPRP2). Three polypeptides of 28, 20, and 14 kilodalton that cross-react with an antibody to RPRP2 accumulate in the culture during steady-state growth. In the presence of the proline hydroxylase inhibitors, all of these repetitive proline-rich proteins disappear. These results indicate that the hydroxyproline-rich proteins play a role in cell growth, and that hydroxylation may regulate the steady-state level of at least one of these proteins by influencing its turnover.

Marcus Abraham. Poverty and poor relief in eighteenth century Aleppo. In: Revue du monde musulman et de la Méditerranée, n°55-56, 1990. Villes au Levant. pp. 171-179.

The rate of synthesis of RNA during early germination of wheat and soybean embryos was investigated by ascertaining the incorporation of radioactive uridine into RNA. In wheat embryos, where the lag period preceding rapid growth is 5.5 hours, there is a 2-fold increase in RNA synthesis between 1.5 and 5.5 hours, with half of the increase occurring by 3.5 hours. In soybean axes, where the lag period is 9.5 hours, the increased rate of RNA synthesis is 5.5-fold between 1.5 and 9.5 hours, with three fourths of this increase occurring after 4 hours. Analysis of the ratio of radioactivity incorporated into the 18S and 26S rRNAs of the germinating embryos provided a further measure of the increased rates of RNA synthesis. With wheat embryos, the 26S/18S ratio increased from 1.0 at 1.5 hours to 1.5 at 3.5 hours, while with the soybean axes, distinct ribosomal patterns were obtained only after 4 hours and the 26S/18S rRNA ratio increased from 0.4 at 4 hours to 1.0 at 9 hours. The extent of methylation of the rRNA synthesized at 4 and 9 hours in the soybean axes was similar, indicating that the methylating capacity of the axes is probably not rate limiting to rRNA synthesis. In both seed embryo systems the level of UTP increased 2 to 3-fold during the lag phase of germination. With wheat embryos, the time course of the increase in UTP correlated approximately with the change in the rate of RNA synthesis. With the soybean axes, however, the increase in the rate of RNA synthesis occurred predominantly after the rise in the level of UTP.

Wheat ( Triticum aestivum L. var. Lew) embryonic axes take up externally supplied radioactive amino acid (from a solution greater than 2 millimolar) such that the specific radioactivity of the total internal amino acid rapidly reaches that of the external solution. Nevertheless, incorporation of radioactive amino acid into protein increases steadily as the concentration of external amino acid is increased, indicating that the amino acid that is precursor to protein synthesis is not in equilibrium with the total internal amino acid pool. When the external source of amino acid is removed, incorporation of radiolabeled amino acid into protein continues at a rate comparable to that of embryos maintained in the radioactive solution. In explanation of these data, it is suggested that there are two separate cytoplasmic pools of amino acids, one a protein synthesis precursor pool, and the second, an expandable pool into which exogenous radioactive amino acids are taken up. The protein synthesis pool is fed at a limited rate from the expandable pool and at a far greater rate from an endogenous source. As a consequence, the specific activity of the amino acid that is the precursor for protein synthesis is considerably below that of the total internal pool and is determined by the rate of movement into the protein synthesis pool from the expanded radioactive cytoplasmic pool. The rate of movement of amino acids from the expandable pool into the protein synthesis pool increases approximately 5-fold during the initial 4.5 hours of embryo germination. When this change is considered in analyzing the relative rates of protein synthesis, there is probably no more than a 2-fold increase in protein synthetic capacity between embryos germinated for 1.5 and 4.5 hours. The leveling off of the change in transport capacity after 4.5 hours suggests that the earlier increase in the rate of this process may be a necessary step before the embryos can begin to accelerate their growth rate.

Protein synthesis in a resolved homogenate of wheat germ requires ATP and eight factors functioning at the level of protein chain initiation. To identify the component(s) interacting with ATP, the different factors were treated with the ATP affinity analogue 5'-p-fluorosulfonylbenzoyladenosine (FSBA) and tested for their function in protein synthesis. The activity of eukaryotic initiation factor 4A (eIF4A) was strongly curtailed, whereas all other factors were unaffected. At a concentration of 250 microM, AMP, ADP, and ATP protected eIF4A against FSBA inactivation, whereas at a concentration 50 microM, protection was afforded only by ATP. GTP did not protect at a concentration of 250 microM. In another approach, the substrate analogue 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate (TNP-ATP) was found to inhibit protein synthesis in a manner, at least in part, competitive with ATP. Supplementing a TNP-ATP inhibited reaction with eIF4A substantially reversed the inhibition. Except for a small effect by factor C1, no reversal was obtained with any other component. Finally, a preincubation of ribosomes with ATP, mRNA, and eIF4A resulted in the formation of a complex capable of TNP-ATP-resistant amino acid incorporation. These data are interpreted to indicate that the primary interaction of ATP is with eIF4A. A model is proposed reconciling this conclusion with other observations relevant to the mRNA . ribosome attachment reaction.

Wheat germ S100 supernatant was resolved into 10 components, all of which are required for tobacco mosaic virus RNA-directed incorporation of amino acid into protein. Two of the components, C2b and C2a, are, respectively, elongation factors 1 and 2, having molecular weights of 51,000 and 72,000. A third factor (C2e) binds Met-tRNA in a GTP-requiring reaction and is absolutely required for the formation of both 40 S ribosome.Met-tRNAiMet and 80 S ribosome.Met-tRNAiMet complexes. This factor is considered to be eucaryotic initiation factor 2. Formation of 80 S ribosome Met-tRNAiMet complexes is augmented 2 to 3-fold by the simultaneous addition of an mRNA, factor C1, and fraction D2(a + b). Factor C1 also reverses the inhibition of translation by an increased concentration of monovalent cations and promotes the translation of a "competitively inhibited" mRNA. These observations suggest that factor C1 and either factor D2a and D2b (or both) function in mRNA attachment reactions. Factor C1 has a molecular weight of 115,000 and appears to be made up of two or three subunits. Factor D2b has been purified to essential homogeneity and has a molecular weight of 55,000. Its interaction with mRNA and its molecular weight suggest that this factor is the wheat germ equivalent of reticulocyte eucaryotic initiation factor 4A.

A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine. On the likelihood that such a protein might be a hydroxyproline-rich cell-wall glycoprotein (HRGP), cell walls of a soybean cell culture were extracted by procedures used to obtain soluble basic cell-wall glycoproteins, and the proteins were fractionated and purified. A 33-kDa protein (and possibly a 28-kDa protein) was obtained that has an amino acid distribution similar to that of the cDNA clone. The protein lacks histidine and serine and contains 20% hydroxyproline and 20% proline. The HRGP is thus distinct both in its amino acid content and in its pentameric repeat of Pro-Pro-Val-Tyr-Lys, with half of the prolines being hydroxylated.

Wheat germ supernatant is resolved into four fractions, C3alpha, C3beta, D and A, all of which are required in addition to elongation EF1 and EF2 for tobacco mosaic virus-RNA (TMV-RNA)-catalyzed amino acid polymerization. Fractions C3beta and D function in the binding of Met-tRNAiMet to the 40 S ribosomal subunit forming an unstable 40 S-Met-tRNA1Met complex that is detected in sucrose gradients only after fixation with glutaraldehyde. Fraction C3beta binds Met-tRNAiMet suggesting that a C3beta-Met-tRNAiMet complex may be an intermediate in the formation of the 40 S complex. GTP is required for the formation of both the C3beta-Met-tRNAiMet and the 40 S-Met-tRNAiMet complexes. In either reaction the nucleotide is partially replaceable by quanyl-5'-yl methylene diphosphonate (GMP-P (CH2) P) while ATP is inactive. When ATP, C3alpha, mRNA, and magnesium acetate (final concentration 3.6 mM) are added to an incubation reaction containing the 40 S-Met-tRNAiMet complex, a stable 80 S-Met-tRNAiMet complex is formed. Radioactive TM virus-RNA binds specifically to the 80 S-Met-tRNAi complex suggesting that mRNA is a component of this complex. C3beta and D, the fractions required in the formation of the 40 S-Met-tRNAiMet complex, are also required for formation of the 80 S-Met-tRNAiMet complex. In addition, unlabeled Met-trnaiMet does not compete significantly with preformed 40 S-Met-tRNAiMet in the 80 S complex-forming reaction. These observations suggest that the 40 S-Met-tRNAiMet complex is an intermediate in the 80 S reaction. The 80 S-Met-tRNAiMet product of the sequential reaction is reactive with puromycin and on this basis it is tentatively considered to be a functional initiation complex. The additional requirement of Fraction A for amino acid polymerization suggests, however, that the initiation process may be more complex.

Wheat ( Triticum aestivum L.) embryo homogenates have been fractionated into three cell fractions from which RNA was extracted and assayed for mRNA content by in vitro translation and by [ 3 H]polyuridylic acid hybridization. In dry embryos the preformed mRNAs are distributed equally between a rapidly sedimenting “pellet” fraction and a cytoplasmic “ribosomal/subribosomal” fraction. During germination 25 to 40% of the total mRNA becomes polyribosomal. The remaining 60 to 75% is retained in the pellet and ribosomal/subribosomal fractions. To compare the nucleotide sequences of the different mRNA fractions, cDNAs were transcribed from polyribosomal (A+) RNA of 40-minute imbibed embryos and from total A(+) RNA of dry embryos, and the ability of these cDNAs to hybridize with the more prevalent classes of mRNA from the different cell fractions was analyzed. The results suggest that there is no significant difference between the preformed mRNAs that move into polyribosomes and those remaining in the nonpolyribosomal fractions. In addition there appears to be no difference between the mRNAs of polyribosomes from embryos germinated for 45 minutes and 5 hours. Between 5 hours and 2 days, however, there is a considerable change in the mRNA composition of the embryos. We conclude for the prevalent classes of message, that the preformed mRNAs of the wheat embryo are not involved in temporal regulation of early development but that they function primarily to allow a rapid resumption of growth upon exposure of the embryo to water.