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Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate the effects of Momordica charantia (MC) on ovarian tissue injury induced by ovarian ischemia-reperfusion. Twenty-four rats were assigned to three groups: control group, ischemia-reperfusion (I/R) group and IR + MC group. 600 mg/kg MC extract were given rats via orogastric route. 3-hour ischemia and 3-hour reperfusion were performed for IR protocol. At the end of experiment, ovarian tissues were excised, fixed in zinc-formalin and processed for routine paraffin wax tissue embedding. Sections were stained with hematoxylin and eosin. Ovarian sections of control group showed regular histological appearance. In ovarian sections of I/R group, hemorrhage, fibrin accumulation, mononuclear cell infiltration and degenerated follicles were observed. I/R + MC group showed improved histopathology caused by I/R injury. We think that MC extract may protect ovarian tissue integrity and its histological structures.

Objective Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. Methods Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage). Brain tissues were dissected from anesthetized rats 7 days after injury. For biochemical analysis, malondialdehyde, glutathione and myeloperoxidase values were measured. Results In histopathological examination, neuronal damage in brain cortex and changes in blood brain barrier were observed. In the analysis of immunohistochemical and western blot, p38 mitogen-activated protein kinase, vascular endothelial growth factor and cluster of differentiation 68 expression levels were shown. These analyzes demonstrated the beneficial effects of GLPs on brain injury. Conclusion We propose that GLPs treatment after brain injury could be an alternative treatment to decraseing inflammation and edema, preventing neuronal and glial cells degeneration if given in appropriate dosage and in particular time intervals.