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4. Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations

Author

Ahmad Sajjad, Jinfei Mei, Chuanbo Wang, and Hongqi Ai

Subjects
Five lipids, Gamma secretase, Presenilin, Nicastrin, Effect of lipid on GS, Chemistry, QD1-999, Physics, QC1-999
Abstract

Gamma secretase (GS) is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid membranes. The enzyme is responsible for amyloid-β propagation, one of the well-known causes of Alzheimer's disease. However, the effects of lipids on GS activity and structural dynamics are unknown. Therefore, in this study, we performed coarse-grained molecular dynamics simulations to probe the effects of five individual lipids on GS. These lipids included 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-dipalmitoyl-sn-phosphatidylcholine (DOPC), 2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC). These lipids are structurally characterized by different heads (i.e., NH3 [PE] for POPE vs. NC3 [PC] for POPC), number of double bonds (one for POPC vs. two for DOPC), and alkyl tail chain lengths (16:1/18:1 for DOPC vs. 14:0/14:0 for DMPC vs. 12:0/12:0 for DLPC). This indicates distinct microenvironments and adjustable structural elements for catalytic function when GS is embedded. Our results revealed that the presence of more unsaturated bonds in DOPC than in POPC resulted in greater GS stability. Moreover, lipids with short alkyl tail chains or with PC heads instead of PE heads had improved mobility of the sixth transmembrane helix of GS, which is responsible for the considerable active site flexibility and presenilin 1 subunit plasticity. The length of the DMPC alkyl tail chain was between that of DOPC and DLPC because the up-down and cross-correlation motions of GS in DMPC was the lowest among the three lipids, and GS mobility in DMPC was the lowest among all five lipids. This may be because the alkyl tail chain length (i.e., 3. 8 nm thickness of the DMPC bilayer) was suitable for GS embedding, thereby restraining more GS motions than that of the long (DOPC) or short lipids (DLPC). Collectively, these results indicated that GS activity can be modulated through changes in conformational fluctuations, structural perturbations, molecular motion, and cross-correlation motion when embedded in different lipids. Exploration of such fundamental information can reveal the possible mechanisms by which GS is affected by individual lipid species.

Published
2024
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7. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Collaborators, GBD 2019 Antimicrobial Resistance, Ikuta, Kevin S, Swetschinski, Lucien R, Aguilar, Gisela Robles, Sharara, Fablina, Mestrovic, Tomislav, Gray, Authia P, Weaver, Nicole Davis, Wool, Eve E, Han, Chieh, Hayoon, Anna Gershberg, Aali, Amirali, Abate, Semagn Mekonnen, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abd-Elsalam, Sherief, Abebe, Getachew, Abedi, Aidin, Abhari, Amir Parsa, Abidi, Hassan, Aboagye, Richard Gyan, Absalan, Abdorrahim, Ali, Hiwa Abubaker, Acuna, Juan Manuel, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Afzal, Saira, Aghdam, Zahra Babaei, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Araz Ramazan, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Ali, Ahmed, Haroon, Ahmed, Jivan Qasim, Rashid, Tarik Ahmed, Ajami, Marjan, Aji, Budi, Akbarzadeh-Khiavi, Mostafa, Akunna, Chisom Joyqueenet, Hamad, Hanadi Al, Alahdab, Fares, Al-Aly, Ziyad, Aldeyab, Mamoon A, Aleman, Alicia V, Alhalaiqa, Fadwa Alhalaiqa Naji, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Alizadeh, Atiyeh, Aljunid, Syed Mohamed, Allel, Kasim, Almustanyir, Sami, Ameyaw, Edward Kwabena, Amit, Arianna Maever L, Anandavelane, Nivedita, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Anggraini, Dewi, Ansar, Adnan, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y, Areda, Demelash, Aripov, Timur, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Asaduzzaman, Muhammad, Ashraf, Tahira, Athari, Seyyed Shamsadin, Atlaw, Daniel, Attia, Sameh, Ausloos, Marcel, Awoke, Tewachew, Quintanilla, Beatriz Paulina Ayala, Ayana, Tegegn Mulatu, Azadnajafabad, Sina, Jafari, Amirhossein Azari, Darshan, BB, Badar, Muhammad, Badiye, Ashish D, Baghcheghi, Nayereh, Bagherieh, Sara, Baig, Atif Amin, Banerjee, Indrajit, Barac, Aleksandra, Bardhan, Mainak, and Barone-Adesi, Francesco

Subjects
Hematology, Sepsis, Emerging Infectious Diseases, Prevention, Lung, Vaccine Related, Biodefense, Pneumonia, Pneumonia & Influenza, Immunization, Infectious Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Child, Male, Female, Humans, Global Burden of Disease, Syndrome, Africa South of the Sahara, Global Health, Bacterial Infections, Risk Factors, Bacteria, GBD 2019 Antimicrobial Resistance Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundReducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes.MethodsWe estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2·5th and 97·5th percentiles across 1000 posterior draws for each quantity of interest.FindingsFrom an estimated 13·7 million (95% UI 10·9-17·1) infection-related deaths in 2019, there were 7·7 million deaths (5·7-10·2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13·6% (10·2-18·1) of all global deaths and 56·2% (52·1-60·1) of all sepsis-related deaths in 2019. Five leading pathogens-Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa-were responsible for 54·9% (52·9-56·9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185-285) per 100 000 population, and lowest in the high-income super-region, with 52·2 deaths (37·4-71·5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths.InterpretationThe 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development.FundingBill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care, using UK aid funding managed by the Fleming Fund.

Published
2022

9. Tri-system integration in metal-oxide nanocomposites via in-situ solution-processed method for ultrathin flexible transparent electrodes

Author

John Jinwook Kim, Kojima Shuji, Jiawei Zheng, Xinjun He, Ahmad Sajjad, Hong Zhang, Haibin Su, and Wallace C. H. Choy

Subjects
Science
Abstract

Abstract For stable operation of ultrathin flexible transparent electrodes (uFTEs), it is critical to implement effective risk management during concurrent multi-loading operation of electrical bias and mechanical folding cycles in high-humidity environments. Despite extensive efforts in preparing solution-processed uFTEs with cost-effective and high-throughput means, achieving in-situ nano-adhesion in heterogeneous metal-oxide nanocomposites remains challenging. In this work, we observed by serendipity liquid-like behaviour of transparent metal-oxide-semiconductor zinc oxide nanoparticles (ZnONPs) onto silver nanowires (AgNWs) developed by in-situ solution processed method (iSPM). This enabled us to address the long-standing issue of vulnerability in the nanocomposite caused by the interface of dissimilar materials between AgNWs and ZnONPs, resulting in a remarkably improved multi-loading operation. Importantly, substrate-integrated uFTEs constituted of the metal-oxide nanocomposite electrode semi-embedded in the polymer matrix of greatly thin

Published
2024
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11. Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019

Author

Collaborators, GBD 2019 LRI, Kyu, Hmwe Hmwe, Vongpradith, Avina, Sirota, Sarah Brooke, Novotney, Amanda, Troeger, Christopher E, Doxey, Matthew C, Bender, Rose G, Ledesma, Jorge R, Biehl, Molly H, Albertson, Samuel B, Frostad, Joseph Jon, Burkart, Katrin, Bennitt, Fiona B, Zhao, Jeff T, Gardner, William M, Hagins, Hailey, Bryazka, Dana, Dominguez, Regina-Mae Villanueva, Abate, Semagn Mekonnen, Abdelmasseh, Michael, Abdoli, Amir, Abdoli, Gholamreza, Abedi, Aidin, Abedi, Vida, Abegaz, Tadesse M, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abtew, Yonas Derso, Ali, Hiwa Abubaker, Abu-Gharbieh, Eman, Abu-Zaid, Ahmed, Adamu, Kidist, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Muhammad Sohail, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Araz Ramazan, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Jivan Qasim, Rashid, Tarik Ahmed, Akbarzadeh-Khiavi, Mostafa, Hamad, Hanadi Al, Albano, Luciana, Aldeyab, Mamoon A, Alemu, Bezatu Mengistie, Alene, Kefyalew Addis, Algammal, Abdelazeem M, Alhalaiqa, Fadwa Alhalaiqa Naji, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Musa Mohammed, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Al-Jumaily, Adel, Aljunid, Syed Mohamed, Almustanyir, Sami, Al-Raddadi, Rajaa M, Al-Rifai, Rami H Hani, AlRyalat, Saif Aldeen S, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Ameyaw, Edward Kwabena, Dehkordi, Javad Javad Aminian, Amuasi, John H, Amugsi, Dickson A, Anbesu, Etsay Woldu, Ansar, Adnan, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Areda, Demelash, Argaw, Ayele Mamo, Argaw, Zeleke Gebru, Arulappan, Judie, Aruleba, Raphael Taiwo, Asemahagn, Mulusew A, Athari, Seyyed Shamsadin, Atlaw, Daniel, Attia, Engi F, Attia, Sameh, Aujayeb, Avinash, Awoke, Tewachew, Ayana, Tegegn Mulatu, Ayanore, Martin Amogre, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, Azari, Samad, Jafari, Amirhossein Azari, Badar, Muhammad, and Badiye, Ashish D

Subjects
Prevention, Good Health and Well Being, Adult, Child, Female, Male, Humans, Child, Preschool, Aged, Aged, 80 and over, Global Burden of Disease, Bayes Theorem, Sex Characteristics, Pyridinolcarbamate, Global Health, Respiratory Tract Infections, Risk Factors, Particulate Matter, Quality-Adjusted Life Years, GBD 2019 LRI Collaborators, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Microbiology
Abstract

BackgroundThe global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children younger than 5 years. We assessed the burden and trends of LRIs and risk factors across all age groups by sex, for 204 countries and territories.MethodsIn this analysis of data for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we used clinician-diagnosed pneumonia or bronchiolitis as our case definition for LRIs. We included International Classification of Diseases 9th edition codes 079.6, 466-469, 470.0, 480-482.8, 483.0-483.9, 484.1-484.2, 484.6-484.7, and 487-489 and International Classification of Diseases 10th edition codes A48.1, A70, B97.4-B97.6, J09-J15.8, J16-J16.9, J20-J21.9, J91.0, P23.0-P23.4, and U04-U04.9. We used the Cause of Death Ensemble modelling strategy to analyse 23 109 site-years of vital registration data, 825 site-years of sample vital registration data, 1766 site-years of verbal autopsy data, and 681 site-years of mortality surveillance data. We used DisMod-MR 2.1, a Bayesian meta-regression tool, to analyse age-sex-specific incidence and prevalence data identified via systematic reviews of the literature, population-based survey data, and claims and inpatient data. Additionally, we estimated age-sex-specific LRI mortality that is attributable to the independent effects of 14 risk factors.FindingsGlobally, in 2019, we estimated that there were 257 million (95% uncertainty interval [UI] 240-275) LRI incident episodes in males and 232 million (217-248) in females. In the same year, LRIs accounted for 1·30 million (95% UI 1·18-1·42) male deaths and 1·20 million (1·07-1·33) female deaths. Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16-1·18) and 1·31 times (95% UI 1·23-1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortality rates declined at different rates across age groups and an increase in LRI episodes and deaths was estimated among all adult age groups, with males aged 70 years and older having the highest increase in LRI episodes (126·0% [95% UI 121·4-131·1]) and deaths (100·0% [83·4-115·9]). During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (-70·7% [-77·2 to -61·8]). The leading risk factors for LRI mortality varied across age groups and sex. More than half of global LRI deaths in children younger than 5 years were attributable to child wasting (population attributable fraction [PAF] 53·0% [95% UI 37·7-61·8] in males and 56·4% [40·7-65·1] in females), and more than a quarter of LRI deaths among those aged 5-14 years were attributable to household air pollution (PAF 26·0% [95% UI 16·6-35·5] for males and PAF 25·8% [16·3-35·4] for females). PAFs of male LRI deaths attributed to smoking were 20·4% (95% UI 15·4-25·2) in those aged 15-49 years, 30·5% (24·1-36·9) in those aged 50-69 years, and 21·9% (16·8-27·3) in those aged 70 years and older. PAFs of female LRI deaths attributed to household air pollution were 21·1% (95% UI 14·5-27·9) in those aged 15-49 years and 18·2% (12·5-24·5) in those aged 50-69 years. For females aged 70 years and older, the leading risk factor, ambient particulate matter, was responsible for 11·7% (95% UI 8·2-15·8) of LRI deaths.InterpretationThe patterns and progress in reducing the burden of LRIs and key risk factors for mortality varied across age groups and sexes. The progress seen in children younger than 5 years was clearly a result of targeted interventions, such as vaccination and reduction of exposure to risk factors. Similar interventions for other age groups could contribute to the achievement of multiple Sustainable Development Goals targets, including promoting wellbeing at all ages and reducing health inequalities. Interventions, including addressing risk factors such as child wasting, smoking, ambient particulate matter pollution, and household air pollution, would prevent deaths and reduce health disparities.FundingBill & Melinda Gates Foundation.

Published
2022

13. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

Author

Collaborators, GBD 2019 Cancer Risk Factors, Tran, Khanh Bao, Lang, Justin J, Compton, Kelly, Xu, Rixing, Acheson, Alistair R, Henrikson, Hannah Jacqueline, Kocarnik, Jonathan M, Penberthy, Louise, Aali, Amirali, Abbas, Qamar, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed Abdelwahab, Abdoli, Gholamreza, Abdulkadir, Hanan Abdulkadir, Abedi, Aidin, Abegaz, Kedir Hussein, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Absalan, Abdorrahim, Abtew, Yonas Derso, Ali, Hiwa Abubaker, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Acuna, Juan Manuel, Addison, Daniel, Addo, Isaac Yeboah, Adegboye, Oyelola A, Adesina, Miracle Ayomikun, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afrin, Sumia, Afzal, Muhammad Sohail, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Rizwan, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Rashid, Tarik Ahmed, Aiman, Wajeeha, Ajami, Marjan, Akalu, Gizachew Taddesse, Akbarzadeh-Khiavi, Mostafa, Aklilu, Addis, Akonde, Maxwell, Akunna, Chisom Joyqueenet, Hamad, Hanadi Al, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alessy, Saleh Ali, Algammal, Abdelazeem M, Al-Hanawi, Mohammed Khaled, Alhassan, Robert Kaba, Ali, Beriwan Abdulqadir, Ali, Liaqat, Ali, Syed Shujait, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Al-Maweri, Sadeq Ali Ali, Almustanyir, Sami, Alonso, Nivaldo, Alqalyoobi, Shehabaldin, Al-Raddadi, Rajaa M, Al-Rifai, Rami H Hani, Al-Sabah, Salman Khalifah, Al-Tammemi, Ala'a B, Altawalah, Haya, Alvis-Guzman, Nelson, Amare, Firehiwot, Ameyaw, Edward Kwabena, Dehkordi, Javad Javad Aminian, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderson, Jason A, Animut, Yaregal Animut, Anoushiravani, Amir, Anoushirvani, Ali Arash, Ansari-Moghaddam, Alireza, Ansha, Mustafa Geleto, Antony, Benny, Antwi, Maxwell Hubert, Anwar, Sumadi Lukman, and Anwer, Razique

Subjects
Prevention, Cancer, Aetiology, 2.2 Factors relating to the physical environment, Good Health and Well Being, Female, Global Burden of Disease, Global Health, Humans, Male, Neoplasms, Quality-Adjusted Life Years, Risk Assessment, Risk Factors, Smoking, GBD 2019 Cancer Risk Factors Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundUnderstanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.MethodsThe GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented.FindingsGlobally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]).InterpretationThe leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.FundingBill & Melinda Gates Foundation.

Published
2022

16. The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Collaborators, GBD 2019 Adolescent Young Adult Cancer, Alvarez, Elysia M, Force, Lisa M, Xu, Rixing, Compton, Kelly, Lu, Dan, Henrikson, Hannah Jacqueline, Kocarnik, Jonathan M, Harvey, James D, Pennini, Alyssa, Dean, Frances E, Fu, Weijia, Vargas, Martina T, Keegan, Theresa HM, Ariffin, Hany, Barr, Ronald D, Erdomaeva, Yana Arturovna, Gunasekera, D Sanjeeva, John-Akinola, Yetunde O, Ketterl, Tyler G, Kutluk, Tezer, Malogolowkin, Marcio Henrique, Mathur, Prashant, Radhakrishnan, Venkatraman, Ries, Lynn Ann Gloeckler, Rodriguez-Galindo, Carlos, Sagoyan, Garik Barisovich, Sultan, Iyad, Abbasi, Behzad, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abbastabar, Hedayat, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdoli, Amir, Abebe, Haimanot, Abedi, Aidin, Abidi, Hassan, Abolhassani, Hassan, Ali, Hiwa Abubaker, Abu-Gharbieh, Eman, Achappa, Basavaprabhu, Acuna, Juan Manuel, Adedeji, Isaac Akinkunmi, Adegboye, Oyelola A, Adnani, Qorinah Estiningtyas Sakilah, Advani, Shailesh M, Afzal, Muhammad Sohail, Meybodi, Mohamad Aghaie, Ahadinezhad, Bahman, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmadi, Sepideh, Ahmed, Muktar Beshir, Rashid, Tarik Ahmed, Salih, Yusra Ahmed, Aiman, Wajeeha, Akalu, Gizachew Taddesse, Al Hamad, Hanadi, Alahdab, Fares, AlAmodi, Abdulhadi A, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alem, Adugnaw Zeleke, Alem, Dejene Tsegaye, Alemayehu, Yosef, Alhalaiqa, Fadwa Naji, Alhassan, Robert Kaba, Ali, Saqib, Alicandro, Gianfranco, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Alluri, Sunitha, Almasri, Nihad A, Al-Maweri, Sadeq Ali, Almustanyir, Sami, Al-Raddadi, Rajaa M, Alvis-Guzman, Nelson, Ameyaw, Edward Kwabena, Amini, Saeed, Amu, Hubert, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Anvari, Davood, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Argaw, Ayele Mamo, Arshad, Muhammad, Arulappan, Judie, Aryannejad, Armin, Asemi, Zatollah, Jafarabadi, Mohammad Asghari, Atashzar, Mohammad Reza, Atorkey, and Atreya, Alok

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Rare Diseases, Burden of Illness, Cancer, Pediatric, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Adult, Cause of Death, Disability-Adjusted Life Years, Female, Global Burden of Disease, Global Health, Humans, Incidence, Life Expectancy, Male, Mortality, Neoplasms, Prevalence, Risk Factors, Socioeconomic Factors, Young Adult, GBD 2019 Adolescent Young Adult Cancer Collaborators, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundIn estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults.MethodsUsing the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults.FindingsThere were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9-15·6] per 100 000 person-years) and middle SDI (13·6 [12·6-14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9-25·2) DALYs to the global burden of disease, of which 2·7% (1·9-3·6) came from YLDs and 97·3% (96·4-98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally.InterpretationAdolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts.FundingBill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute.

Published
2022

23. Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study

Author

Sharma, Rajesh, Abbastabar, Hedayat, Abdulah, Deldar Morad, Abidi, Hassan, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Absalan, Abdorrahim, Ali, Hiwa Abubaker, Abu-Gharbieh, Eman, Acuna, Juan Manuel, Adib, Nasrin, Sakilah Adnani, Qorinah Estiningtyas, Aghaei, Abbas, Ahmad, Aqeel, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Luai A., Ajami, Marjan, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Alanezi, Fahad Mashhour, Saeed Al-Gheethi, Adel Ali, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Beriwan Abdulqadir, Alimohamadi, Yousef, Aljunid, Syed Mohamed, Ali Al-Maweri, Sadeq Ali, Alqahatni, Saleh A., AlQudah, Mohammad, Al-Raddadi, Rajaa M., Al-Tammemi, Ala'a B., Ansari-Moghaddam, Alireza, Anwar, Sumadi Lukman, Anwer, Razique, Aqeel, Muhammad, Arabloo, Jalal, Arab-Zozani, Morteza, Ariffin, Hany, Artaman, Al, Arulappan, Judie, Ashraf, Tahira, Askari, Elaheh, Athar, Mohammad, Wahbi Atout, Maha Moh'd, Azadnajafabad, Sina, Badar, Muhammad, Badiye, Ashish D., Baghcheghi, Nayereh, Bagherieh, Sara, Bai, Ruhai, Bajbouj, Khuloud, Baliga, Shrikala, Bardhan, Mainak, Bashiri, Azadeh, Baskaran, Pritish, Basu, Saurav, Belgaumi, Uzma Iqbal, Nazer C Bermudez, Amiel, Bhandari, Bharti, Bhardwaj, Nikha, Bhat, Ajay Nagesh, Bitaraf, Saeid, Boloor, Archith, Hashemi, Milad Bonakdar, Butt, Zahid A., Chadwick, Joshua, Kai Chan, Jeffrey Shi, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Cho, William C.S., Darwesh, Aso Mohammad, Dash, Nihar Ranjan, Dehghan, Amin, Dhali, Arkadeep, Dianatinasab, Mostafa, Dibas, Mahmoud, Dixit, Abhinav, Dixit, Shilpi Gupta, Dorostkar, Fariba, Dsouza, Haneil Larson, Elbarazi, Iffat, Elemam, Noha Mousaad, El-Huneidi, Waseem, Elkord, Eyad, Abdou Elmeligy, Omar Abdelsadek, Emamian, Mohammad Hassan, Erkhembayar, Ryenchindorj, Ezzeddini, Rana, Fadoo, Zehra, Faiz, Razana, Fakhradiyev, Ildar Ravisovich, Fallahzadeh, Aida, Faris, MoezAlIslam Ezzat Mahmoud, Farrokhpour, Hossein, Fatehizadeh, Ali, Fattahi, Hamed, Fekadu, Ginenus, Fukumoto, Takeshi, Gaidhane, Abhay Motiramji, Galehdar, Nasrin, Garg, Priyanka, Ghadirian, Fataneh, Ghafourifard, Mansour, Ghasemi, MohammadReza, Nour, Mohammad Ghasemi, Ghassemi, Fariba, Gholamalizadeh, Maryam, Gholamian, Asadollah, Ghotbi, Elena, Golechha, Mahaveer, Goleij, Pouya, Goyal, Sahil, Mohialdeen Gubari, Mohammed Ibrahim, Gunasekera, D Sanjeeva, Gunawardane, Damitha Asanga, Gupta, Sapna, Habibzadeh, Parham, Haeri Boroojeni, Helia Sadat, Halboub, Esam S., Hamadeh, Randah R., Hamoudi, Rifat, Harorani, Mehdi, Hasanian, Mohammad, Hassan, Treska S., Hay, Simon I., Heidari, Mohammad, Heidari-Foroozan, Mahsa, Hessami, Kamran, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hoseini, Mohammad, Hossain, Md Mahbub, Hossain, Sahadat, Hsieh, Vivian Chia-rong, Huang, Junjie, Hussein, Nawfal R., Hwang, Bing-Fang, Iravanpour, Farideh, Ismail, Nahlah Elkudssiah, Iwagami, Masao, Merin J, Linda, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jahani, Mohammad Ali, Jahrami, Haitham, Jaiswal, Abhishek, Jakovljevic, Mihajlo, Jalili, Mahsa, Jamshidi, Elham, Jayarajah, Umesh, Jayaram, Shubha, Jha, Sweety Suman, Jokar, Mohammad, Joseph, Nitin, Kabir, Ali, Kabir, Md. Awal, Kadir, Dler Hussein, Kakodkar, Pradnya Vishal, Kalankesh, Laleh R., Kalankesh, Leila R., Kalhor, Rohollah, Kaliyadan, Feroze, Kamal, Vineet Kumar, Kamal, Zul, Kamath, Ashwin, Kar, Sitanshu Sekhar, Karimi, Hanie, Kaur, Navjot, Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khan, Ejaz Ahmad, Khan, M Nuruzzaman, Khan, Maseer, Khan, Moien A.B., Khan, Yusra H., Khanmohammadi, Shaghayegh, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khayamzadeh, Maryam, Khayat Kashani, Hamid Reza, Kim, Min Seo, Kompani, Farzad, Koohestani, Hamid Reza, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Kumar, Narinder, Kumar, Naveen, Kutluk, Tezer, Kuttikkattu, Ambily, Ching Lai, Daphne Teck, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lasrado, Savita, Lee, Sang-Woong, Lee, Seung Won, Lee, Yeong Yeh, Lee, Yo Han, Leong, Elvynna, Li, Ming-Chieh, Liu, Jue, Madadizadeh, Farzan, Mafi, Ahmad R., Mahjoub, Soleiman, Malekzadeh, Reza, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Mansournia, Mohammad Ali, Martini, Santi, Mathews, Elezebeth, Mathur, Manu Raj, Meena, Jitendra Kumar, Menezes, Ritesh G., Mirfakhraie, Reza, Mirinezhad, Seyed Kazem, Mirza-Aghazadeh-Attari, Mohammad, Mithra, Prasanna, Mohamadkhani, Ashraf, Mohammadi, Soheil, Mohammadzadeh, Maryam, Mohan, Syam, Mokdad, Ali H., Al Montasir, Ahmed, Montazeri, Fateme, Moradi, Maryam, Sarabi, Mostafa Moradi, Moradpour, Farhad, Moradzadeh, Maliheh, Moraga, Paula, Mosapour, Abbas, Motaghinejad, Majid, Mubarik, Sumaira, Muhammad, Jibran Sualeh, Murray, Christopher J.L., Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Nargus, Shumaila, Natto, Zuhair S., Nayak, Biswa Prakash, Nejadghaderi, Seyed Aria, Nguyen, Phuong The, Niazi, Robina Khan, Noroozi, Nafise, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Ong, Sokking, Oommen, Anu Mary, Padubidri, Jagadish Rao, Pandey, Ashok, Park, Eun-Kee, Park, Seoyeon, Pati, Siddhartha, Patil, Shankargouda, Paudel, Rajan, Paudel, Uttam, Pirestani, Majid, Podder, Indrashis, Pourali, Ghazaleh, Pourjafar, Mona, Pourshams, Akram, Syed, Zahiruddin Quazi, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Rahman, Mosiur, Rahmani, Shayan, Rahmanian, Vahid, Ramesh, Pushkal Sinduvadi, Rana, Juwel, Rao, Indu Ramachandra, Rao, Sowmya J., Rashedi, Sina, Rashidi, Mohammad-Mahdi, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaei, Saeid, Rezaeian, Mohsen, Roshandel, Gholamreza, Chandan, S.N., Saber-Ayad, Maha Mohamed, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Saeed, Umar, Safi, Sher Zaman, Sharif-Askari, Fatemeh Saheb, Sahebkar, Amirhossein, Sahoo, Harihar, Sajedi, Seyed Aidin, Sajid, Mirza Rizwan, Salehi, Mohammad Amin, Farrokhi, Amir Salek, Sarasmita, Made Ary, Sargazi, Saman, Sarode, Gargi Sachin, Sarode, Sachin C., Sathian, Brijesh, Satpathy, Maheswar, Semwal, Prabhakar, Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Shafeghat, Melika, Shahabi, Saeed, Shahbandi, Ataollah, Shahraki-Sanavi, Fariba, Shaikh, Masood Ali, Shannawaz, Mohammed, Sheikhi, Rahim Ali, Shobeiri, Parnian, Shorofi, Seyed Afshin, Shrestha, Sunil, Siabani, Soraya, Singh, Garima, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Siwal, Samarjeet Singh, Sreeram, Saraswathy, Suleman, Muhammad, Abdulkader, Rizwan Suliankatchi, Sultan, Iyad, Sultana, Abida, Tabish, Mohammad, Tabuchi, Takahiro, Taheri, Majid, Talaat, Iman M., Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Thangaraju, Pugazhenthan, Thomas, Nihal, Thomas, Nikhil Kenny, Tiyuri, Amir, Tobe-Gai, Ruoyan, Toghroli, Razie, Tovani-Palone, Marcos Roberto, Ullah, Sana, Unnikrishnan, Bhaskaran, Upadhyay, Era, Tahbaz, Sahel Valadan, Valizadeh, Rohollah, Varthya, Shoban Babu, Waheed, Yasir, Wang, Song, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Xiao, Hong, Yonemoto, Naohiro, Younis, Mustafa Z., Yu, Chuanhua, Zahir, Mazyar, Zaki, Nazar, Zamanian, Maryam, Zhang, Zhi-Jiang, Zhao, Hanqing, Zitoun, Osama A., and Zoladl, Mohammad

Published
2024
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28. New 2,4-dihydro-1H-1,2,4-triazole-3-selones and 3,3′-di(4H-1,2,4-triazolyl)diselenides. Synthesis, biological evaluation, and in silico studies as antibacterial and fungicidal agents

Author

oglu Askerov, Rizvan K., eL Bakri, Youness, Osmanov, Vladimir K., Chipinsky, Evgeny V., Ahmad, Sajjad, Matsulevich, Zanna V., Borisova, Galina N., Kuzina, Olga V., Khrustalev, Victor N., Peregudov, Alexander S., Chizhov, Alexander O., oglu Magerramov, Abel M., Al-Salahi, Rashad, and Borisov, Aleksandr V.

Published
2023
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29. Global, regional, and national mortality due to unintentional carbon monoxide poisoning, 2000–2021: results from the Global Burden of Disease Study 2021

Author

Moberg, Madeline E, Hamilton, Erin B, Zeng, Scott M, Bryazka, Dana, Zhao, Jeff T, Feldman, Rachel, Abate, Yohannes Habtegiorgis, Abbasi-Kangevari, Mohsen, Abdurehman, Ame Mehadi, Abedi, Aidin, Abu-Gharbieh, Eman, Addo, Isaac Yeboah, Adepoju, Abiola Victor, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmed, Danial, Ahmed, Haroon, Alem, Dejene Tsegaye, Al-Gheethi, Adel Ali Saeed, Alimohamadi, Yousef, Ameyaw, Edward Kwabena, Amrollahi-Sharifabadi, Mohammad, Anagaw, Tadele Fentabil, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Aravkin, Aleksandr Y, Athari, Seyyed Shamsadin, Atreya, Alok, Azari Jafari, Amirhossein, Badiye, Ashish D, Baghcheghi, Nayereh, Bagherieh, Sara, Bansal, Hansi, Barrow, Amadou, Bashiri, Azadeh, Bayileyegn, Nebiyou Simegnew, Berhie, Alemshet Yirga, Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Boloor, Archith, Cámera, Luis Alberto, Carvalho, Felix, Carvalho, Márcia, Chandrasekar, Eeshwar K, Chang, Jung-Chen, Chattu, Vijay Kumar, Chu, Dinh-Toi, Coberly, Kaleb, Cruz-Martins, Natália, Dadras, Omid, Dai, Xiaochen, Darvishi Cheshmeh Soltani, Reza, Das, Saswati, Das, Subasish, Debela, Sisay Abebe, Demessa, Berecha Hundessa, Deng, Xinlei, Desta, Abebaw Alemayehu, Desye, Belay, Dhimal, Meghnath, Dibas, Mahmoud, Dsouza, Haneil Larson, Ekholuenetale, Michael, El Sayed, Iman, El-Huneidi, Waseem, Enyew, Daniel Berhanie, Fagbamigbe, Adeniyi Francis, Fatehizadeh, Ali, Fatima, Syeda Anum Fatima, Fischer, Florian, Franklin, Richard Charles, Garg, Tushar, Gebi, Tilaye Gebru, Gerema, Urge, Getachew, Melaku, Getachew, Motuma Erena, Ghamari, Farhad, Golechha, Mahaveer, Goleij, Pouya, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Harorani, Mehdi, Hasani, Hamidreza, Hassan, Abbas M, Hassanian-Moghaddam, Hossein, Hassen, Mohammed Bheser, Hay, Simon I, Hayat, Khezar, Heidari, Mohammad, Heidari-Foroozan, Mahsa, Heyi, Demisu Zenbaba, Holla, Ramesh, Hoogar, Praveen, Hossain, Md Shakhaoat, Hosseini, Mohammad-Salar, Hostiuc, Sorin, Hoveidamanesh, Soodabeh, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Immurana, Mustapha, Iwu, Chidozie C D, Jayarajah, Umesh, Joseph, Nitin, Joshua, Charity Ehimwenma, Kadashetti, Vidya, Kanchan, Tanuj, Kandel, Himal, Kantar, Rami S, Kapoor, Neeti, Karaye, Ibraheem M, Katoto, Patrick DMC, Khajuria, Himanshu, Khan, Ejaz Ahmad, Khateri, Sorour, Khodamoradi, Farzad, Khormali, Moein, Khubchandani, Jagdish, Kim, Grace, Kisa, Adnan, Koohestani, Hamid Reza, Krishan, Kewal, Kumar, Naveen, Laflamme, Lucie, Landires, Iván, Larijani, Bagher, Lauriola, Paolo, Le, Thao Thi Thu, Ledda, Caterina, Lee, Seung Won, Lim, Stephen S, Lobo, Stany W, Lunevicius, Raimundas, Maharaj, Sandeep B, Menezes, Ritesh G, Mentis, Alexios-Fotios A, Mestrovic, Tomislav, Miller, Ted R, Mirmoeeni, Seyyedmohammadsadeq, Misganaw, Awoke, Mishra, Manish, Misra, Sanjeev, Mittal, Chaitanya, Mohammadi, Esmaeil, Mokdad, Ali H, Moni, Mohammad Ali, Mostafavi, Ebrahim, Mubarik, Sumaira, Mulita, Francesk, Mulualem, Jember Azanaw, Mulugeta, Temesgen, Murray, Christopher J L, Myers, Isabella, Nayak, Biswa Prakash, Nayak, Vinod C, Nejadghaderi, Seyed Aria, Nguyen, Huong Lan Thi, Nguyen, Van Thanh, Nouraei, Hasti, Nzoputam, Ogochukwu Janet, Okati-Aliabad, Hassan, Olufadewa, Isaac Iyinoluwa, Ordak, Michal, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pandey, Ashok, Pant, Suman, Parekh, Utsav, Pawar, Shrikant, Peden, Amy E, Petcu, Ionela-Roxana, Piel, Frédéric B, Piracha, Zahra Zahid, Pourali, Ghazaleh, Qattea, Ibrahim, Qureshi, Maryam Faiz, Raghav, Pankaja Raghav, Rahman, Mosiur, Rahmani, Shayan, Ramasubramani, Premkumar, Ramazanu, Sheena, Rawaf, Salman, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Saddik, Basema, Sadeghi, Malihe, Sadeghian, Farideh, Saeed, Umar, Sahebkar, Amirhossein, Saif, Zahra, Sakshaug, Joseph W, Salahi, Saina, Salamati, Payman, Samy, Abdallah M, Sarmiento-Suárez, Rodrigo, Schwebel, David C, Senthilkumaran, Subramanian, Seylani, Allen, Shaikh, Masood Ali, Sham, Sunder, Shashamo, Bereket Beyene, Sheikhi, Rahim Ali, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Sibhat, Migbar Mekonnen, Singh, Harpreet, Singh, Paramdeep, Sisay, Eskinder Ayalew, Solomon, Yonatan, Taheri, Majid, Ullah, Irfan, Ullah, Sana, Violante, Francesco S, Vu, Linh Gia, Wickramasinghe, Nuwan Darshana, Yigit, Arzu, Yonemoto, Naohiro, Yousefi, Zabihollah, Zaman, Muhammad, Zastrozhin, Mikhail Sergeevich, Zhang, Zhi-Jiang, Zheng, Peng, Zoladl, Mohammad, Steinmetz, Jaimie D, Vos, Theo, Naghavi, Mohsen, and Ong, Kanyin Liane

Published
2023
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30. Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

Author

Wu, Dongze, Jin, Yingzhao, Xing, Yuhan, Abate, Melsew Dagne, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abd-Allah, Foad, Abdelmasseh, Michael, Abdollahifar, Mohammad-Amin, Abdulah, Deldar Morad, Abedi, Aidin, Abedi, Vida, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abuabara, Katrina, Abyadeh, Morteza, Addo, Isaac Yeboah, Adeniji, Kayode Nelson, Adepoju, Abiola Victor, Adesina, Miracle Ayomikun, Sakilah Adnani, Qorinah Estiningtyas, Afarideh, Mohsen, Aghamiri, Shahin, Agodi, Antonella, Agrawal, Anurag, Aguilera Arriagada, Constanza Elizabeth, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Sajjad, Ahmad, Sohail, Ahmadi, Ali, Ahmed, Ali, Ahmed, Ayman, Aithala, Janardhana P., Ajadi, Abdullateef Abiodun, Ajami, Marjan, Akbarzadeh-Khiavi, Mostafa, Alahdab, Fares, AlBataineh, Mohammad T., Alemi, Sharifullah, Saeed Al-Gheethi, Adel Ali, Ali, Liaqat, Alif, Sheikh Mohammad, Almazan, Joseph Uy, Almustanyir, Sami, Alqahtani, Jaber S., Alqasmi, Ibrahim, Khan Altaf, Ihsan Ullah, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Al-Worafi, Yaser Mohammed, Aly, Hany, Amani, Reza, Amu, Hubert, Amusa, Ganiyu Adeniyi, Andrei, Catalina Liliana, Ansar, Adnan, Ansariniya, Hossein, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arefnezhad, Reza, Arulappan, Judie, Asghari-Jafarabadi, Mohammad, Ashraf, Tahira, Atata, Jamila Abdulhamid, Athari, Seyyed Shamsadin, Atlaw, Daniel, Wahbi Atout, Maha Moh'd, Aujayeb, Avinash, Awan, Asma Tahir, Ayatollahi, Haleh, Azadnajafabad, Sina, Azzam, Ahmed Y., Badawi, Alaa, Badiye, Ashish D., Bagherieh, Sara, Baig, Atif Amin, Bantie, Berihun Bantie, Barchitta, Martina, Bardhan, Mainak, Barker-Collo, Suzanne Lyn, Barone-Adesi, Francesco, Batra, Kavita, Bayileyegn, Nebiyou Simegnew, Behnoush, Amir Hossein, Belgaumi, Uzma Iqbal, Bemanalizadeh, Maryam, Bensenor, Isabela M., Beyene, Kebede A., Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bitaraf, Saeid, Bitra, Veera R., Boloor, Archith, Bora, Kaustubh, Botelho, João Silva, Buchbinder, Rachelle, Calina, Daniela, Cámera, Luis Alberto, Carvalho, Andre F., Kai Chan, Jeffrey Shi, Chattu, Vijay Kumar, Abebe, Endeshaw Chekol, Chichagi, Fatemeh, Choi, Sungchul, Chou, Tzu-Chieh, Chu, Dinh-Toi, Coberly, Kaleb, Costa, Vera Marisa, Couto, Rosa A.S., Cruz-Martins, Natália, Dadras, Omid, Dai, Xiaochen, Damiani, Giovanni, Dascalu, Ana Maria, Dashti, Mohsen, Debela, Sisay Abebe, Dellavalle, Robert Paul, Demetriades, Andreas K., Demlash, Alemayehu Anley, Deng, Xinlei, Desai, Hardik Dineshbhai, Desai, Rupak, Rahman Dewan, Syed Masudur, Dey, Sourav, Dharmaratne, Samath Dhamminda, Diaz, Daniel, Dibas, Mahmoud, Dinis-Oliveira, Ricardo Jorge, Diress, Mengistie, Do, Thanh Chi, Doan, Duy Khanh, Dodangeh, Masoud, Dodangeh, Milad, Dongarwar, Deepa, Dube, John, Dziedzic, Arkadiusz Marian, Ed-Dra, Abdelaziz, Edinur, Hisham Atan, Eissazade, Negin, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elemam, Noha Mousaad, Elhadi, Muhammed, Elmehrath, Ahmed O., Abdou Elmeligy, Omar Abdelsadek, Emamverdi, Mehdi, Emeto, Theophilus I., Esayas, Hawi Leul, Eshetu, Habitu Birhan, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faghani, Shahriar, Fakhradiyev, Ildar Ravisovich, Fatehizadeh, Ali, Fathi, Mobina, Feizkhah, Alireza, Fekadu, Ginenus, Fereidouni, Mohammad, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C., Ferrara, Pietro, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Foroutan, Behzad, Foroutan, Masoud, Fukumoto, Takeshi, Ganesan, Balasankar, Belete Gemeda, Belete Negese, Ghamari, Seyyed-Hadi, Ghasemi, MohammadReza, Gholamalizadeh, Maryam, Gill, Tiffany K., Gillum, Richard F., Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Goudarzi, Houman, Guan, Shi-Yang, Guo, Yang, Gupta, Bhawna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haddadi, Rasool, Hadi, Najah R., Halwani, Rabih, Haque, Shafiul, Hasan, Ikramul, Hashempour, Reza, Hassan, Amr, Hassan, Treska S., Hassanzadeh, Sara, Hassen, Mohammed Bheser, Haubold, Johannes, Hayat, Khezar, Heidari, Golnaz, Heidari, Mohammad, Heidari-Soureshjani, Reza, Herteliu, Claudiu, Hessami, Kamran, Hezam, Kamal, Hiraike, Yuta, Holla, Ramesh, Hosseini, Mohammad-Salar, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilic, Irena M., Ilic, Milena D., Iranmehr, Arad, Iravanpour, Farideh, Ismail, Nahlah Elkudssiah, Iwagami, Masao, Iwu, Chidozie C.D., Jacob, Louis, Jafarinia, Morteza, Jafarzadeh, Abdollah, Jahankhani, Kasra, Jahrami, Haitham, Jakovljevic, Mihajlo, Jamshidi, Elham, Jani, Chinmay T., Janodia, Manthan Dilipkumar, Jayapal, Sathish Kumar, Jayaram, Shubha, Jeganathan, Jayakumar, Jonas, Jost B., Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Vaishali, K., Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kaliyadan, Feroze, Kalroozi, Fatemeh, Kamal, Vineet Kumar, Kandel, Amit, Kandel, Himal, Kanungo, Srikanta, Karami, Jafar, Karaye, Ibraheem M., Karimi, Hanie, Kasraei, Hengameh, Kazemian, Sina, Kebede, Sewnet Adem, Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khamesipour, Faham, Khan, Ejaz Ahmad, Khan, Imteyaz A., Khan, Maseer, Khan, Md Jobair, Khan, Moien A.B., Khan, Muhammad Arslan, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khateri, Sorour, Khayat Kashani, Hamid Reza, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Koh, Hyun Yong, Kolkhir, Pavel, Korzh, Oleksii, Kotnis, Ashwin Laxmikant, Koul, Parvaiz A., Koyanagi, Ai, Krishan, Kewal, Kuddus, Mohammed, Kulkarni, Vishnutheertha Vishnutheertha, Kumar, Narinder, Kundu, Satyajit, Kurmi, Om P., La Vecchia, Carlo, Lahariya, Chandrakant, Laksono, Tri, Lám, Judit, Latief, Kamaluddin, Lauriola, Paolo, Lawal, Basira Kankia, Thu Le, Thao Thi, Bich Le, Trang Thi, Lee, Munjae, Lee, Seung Won, Lee, Wei-Chen, Lee, Yo Han, Lenzi, Jacopo, Levi, Miriam, Li, Wei, Ligade, Virendra S., Lim, Stephen S., Liu, Gang, Liu, Xuefeng, Llanaj, Erand, Lo, Chun-Han, Machado, Vanessa Sintra, Maghazachi, Azzam A., Mahmoud, Mansour Adam, Mai, Tuan A., Majeed, Azeem, Sanaye, Pantea Majma, Makram, Omar Mohamed, Rad, Elaheh Malakan, Malhotra, Kashish, Malik, Ahmad Azam, Malik, Iram, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martorell, Miquel, Masoudi, Sahar, Masoumi, Seyedeh Zahra, Mathangasinghe, Yasith, Mathews, Elezebeth, Mathioudakis, Alexander G., Maugeri, Andrea, Mayeli, Mahsa, Carabeo Medina, John Robert, Meles, Gebrekiros Gebremichael, Mendes, José João, Menezes, Ritesh G., Mestrovic, Tomislav, Michalek, Irmina Maria, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mihretie, Ephrem Tesfaye, Nhat Minh, Le Huu, Mirfakhraie, Reza, Mirrakhimov, Erkin M., Misganaw, Awoke, Mohamadkhani, Ashraf, Mohamed, Nouh Saad, Mohammadi, Faezeh, Mohammadi, Soheil, Mohammed, Salahuddin, Mohammed, Shafiu, Mohan, Syam, Mohseni, Anita, Mokdad, Ali H., Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moniruzzaman, Md, Moradi, Yousef, Morovatdar, Negar, Mostafavi, Ebrahim, Mousavi, Parsa, Mukoro, George Duke, Mulita, Admir, Mulu, Getaneh Baye, Murillo-Zamora, Efrén, Musaigwa, Fungai, Mustafa, Ghulam, Muthu, Sathish, Nainu, Firzan, Nangia, Vinay, Swamy, Sreenivas Narasimha, Natto, Zuhair S., Navaraj, Perumalsamy, Nayak, Biswa Prakash, Nazri-Panjaki, Athare, Negash, Hadush, Nematollahi, Mohammad Hadi, Nguyen, Dang H., Hien Nguyen, Hau Thi, Nguyen, Hien Quang, Nguyen, Phat Tuan, Nguyen, Van Thanh, Niazi, Robina Khan, Nikolouzakis, Taxiarchis Konstantinos, Nnyanzi, Lawrence Achilles, Noreen, Mamoona, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Oh, In-Hwan, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Okwute, Patrick Godwin, Olagunju, Andrew T., Olatubi, Matthew Idowu, Olufadewa, Isaac Iyinoluwa, Ordak, Michal, Otstavnov, Nikita, Owolabi, Mayowa O., Mahesh, P.A., Padubidri, Jagadish Rao, Pak, Anton, Pakzad, Reza, Palladino, Raffaele, Pana, Adrian, Pantazopoulos, Ioannis, Papadopoulou, Paraskevi, Pardhan, Shahina, Parthasarathi, Ashwaghosha, Pashaei, Ava, Patel, Jay, Pathan, Aslam Ramjan, Patil, Shankargouda, Paudel, Uttam, Pawar, Shrikant, Pedersini, Paolo, Pensato, Umberto, Pereira, David M., Pereira, Jeevan, Pereira, Maria Odete, Pereira, Renato B., Peres, Mario F.P., Perianayagam, Arokiasamy, Perna, Simone, Petcu, Ionela-Roxana, Pezeshki, Parmida Sadat, Pham, Hoang Tran, Philip, Anil K., Piradov, Michael A., Podder, Indrashis, Podder, Vivek, Poddighe, Dimitri, Sady Prates, Elton Junio, Qattea, Ibrahim, Radfar, Amir, Raee, Pourya, Rafiei, Alireza, Raggi, Alberto, Rahim, Fakher, Rahimi, Mehran, Rahimifard, Mahban, Rahimi-Movaghar, Vafa, Rahman, Md Obaidur, Ur Rahman, Mohammad Hifz, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Mohamed, Rahmani, Shayan, Rahmanian, Vahid, Ramasubramani, Premkumar, Rancic, Nemanja, Rao, Indu Ramachandra, Rashedi, Sina, Rashid, Ahmed Mustafa, Ravikumar, Nakul, Rawaf, Salman, Mohamed Redwan, Elrashdy Moustafa, Rezaei, Nazila, Rezaei, Negar, Rezaei, Nima, Rezaeian, Mohsen, Ribeiro, Daniela, Rodrigues, Mónica, Buendia Rodriguez, Jefferson Antonio, Roever, Leonardo, Romero-Rodríguez, Esperanza, Saad, Aly M.A., Saddik, Basema, Sadeghian, Saeid, Saeed, Umar, Safary, Azam, Safdarian, Mahdi, Safi, Sher Zaman, Saghazadeh, Amene, Sagoe, Dominic, Sharif-Askari, Fatemeh Saheb, Sharif-Askari, Narjes Saheb, Sahebkar, Amirhossein, Sahoo, Harihar, Sahraian, Mohammad Ali, Sajid, Mirza Rizwan, Sakhamuri, Sateesh, Sakshaug, Joseph W., Saleh, Mohamed A., Salehi, Leili, Salehi, Sana, Farrokhi, Amir Salek, Samadzadeh, Sara, Samargandy, Saad, Samieefar, Noosha, Samy, Abdallah M., Sanadgol, Nima, Sanjeev, Rama Krishna, Sawhney, Monika, Saya, Ganesh Kumar, Schuermans, Art, Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Sethi, Yashendra, Shafie, Mahan, Shah, Humaira, Shahid, Izza, Shahid, Samiah, Shaikh, Masood Ali, Sharfaei, Sadaf, Sharma, Manoj, Shayan, Maryam, Shehata, Hatem Samir, Sheikh, Aziz, Shetty, Jeevan K., Shin, Jae Il, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shivakumar, K.M., Shivarov, Velizar, Shobeiri, Parnian, Siabani, Soraya, Sibhat, Migbar Mekonnen, Siddig, Emmanuel Edwar, Simpson, Colin R., Sinaei, Ehsan, Singh, Harpreet, Singh, Inderbir, Singh, Jasvinder A., Singh, Paramdeep, Singh, Surjit, Siraj, Md Shahjahan, Al Mamun Sohag, Abdullah, Solanki, Ranjan, Solikhah, Solikhah, Solomon, Yonatan, Soltani-Zangbar, Mohammad Sadegh, Sun, Jing, Szeto, Mindy D., Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabish, Mohammad, Taheri, Ensiyeh, Tahvildari, Azin, Talaat, Iman M., Lukenze Tamuzi, Jacques J.L., Tan, Ker-Kan, Tat, Nathan Y., Oliaee, Razieh Tavakoli, Tavasol, Arian, Temsah, Mohamad-Hani, Thangaraju, Pugazhenthan, Tharwat, Samar, Tibebu, Nigusie Selomon, Vera Ticoalu, Jansje Henny, Tillawi, Tala, Tiruye, Tenaw Yimer, Tiyuri, Amir, Tovani-Palone, Marcos Roberto, Tripathi, Manjari, Tsegay, Guesh Mebrahtom, Tualeka, Abdul Rohim, Ty, Sree Sudha, Ubah, Chukwudi S., Ullah, Saif, Ullah, Sana, Umair, Muhammad, Umakanthan, Srikanth, Upadhyay, Era, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Tahbaz, Sahel Valadan, Valizadeh, Rohollah, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Verras, Georgios-Ioannis, Villafañe, Jorge Hugo, Vlassov, Vasily, Vo, Danh Cao, Waheed, Yasir, Waris, Abdul, Welegebrial, Brhane Gebrehiwot, Westerman, Ronny, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Willekens, Barbara, Woldegeorgis, Beshada Zerfu, Woldemariam, Melat, Xiao, Hong, Yada, Dereje Y., Yahya, Galal, Yang, Lin, Yazdanpanah, Fereshteh, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Zahir, Mazyar, Zaidi, Syed Saoud, Zangiabadian, Moein, Zare, Iman, Zeineddine, Mohammad A., Zemedikun, Dawit T., Zeru, Naod Gebrekrstos, Zhang, Chen, Zhao, Hanqing, Zhong, Chenwen, Zielińska, Magdalena, Zoladl, Mohammad, Zumla, Alimuddin, Guo, Cui, and Tam, Lai-shan

Published
2023
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32. Vaginal Microbiome-Based Bacterial Signatures for Predicting the Severity of Cervical Intraepithelial Neoplasia.

Author

Lee, Yoon, Kang, Gi-Ung, Jeon, Se, Tagele, Setu, Pham, Huy, Kim, Min-Sueng, Ahmad, Sajjad, Jung, Da-Ryung, Park, Yeong-Jun, Han, Hyung, Shin, Jae-Ho, and Chong, Gun

Subjects
cervical intraepithelial neoplasia, machine learning, vaginal microbiome
Abstract

Although emerging evidence revealed that the gut microbiome served as a tool and as biomarkers for predicting and detecting specific cancer or illness, it is yet unknown if vaginal microbiome-derived bacterial markers can be used as a predictive model to predict the severity of CIN. In this study, we sequenced V3 region of 16S rRNA gene on vaginal swab samples from 66 participants (24 CIN 1-, 42 CIN 2+ patients) and investigated the taxonomic composition. The vaginal microbial diversity was not significantly different between the CIN 1- and CIN 2+ groups. However, we observed Lactobacillus amylovorus dominant type (16.7%), which does not belong to conventional community state type (CST). Moreover, a minimal set of 33 bacterial species was identified to maximally differentiate CIN 2+ from CIN 1- in a random forest model, which can distinguish CIN 2+ from CIN 1- (area under the curve (AUC) = 0.952). Among the 33 bacterial species, Lactobacillus iners was selected as the most impactful predictor in our model. This finding suggests that the random forest model is able to predict the severity of CIN and vaginal microbiome may play a role as biomarker.

Published
2020

35. Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Author

Momtazmanesh, Sara, Moghaddam, Sahar Saeedi, Ghamari, Seyyed-Hadi, Rad, Elaheh Malakan, Rezaei, Negar, Shobeiri, Parnian, Aali, Amirali, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdoun, Meriem, Abdulah, Deldar Morad, Md Abdullah, Abu Yousuf, Abedi, Aidin, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Achappa, Basavaprabhu, Adane Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adnan, Mohammad, Sakilah Adnani, Qorinah Estiningtyas, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ali, Ahmed, Ayman, Rashid, Tarik Ahmed, Al Hamad, Hanadi, Alahdab, Fares, Alemayehu, Astawus, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Almustanyir, Sami, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Dehkordi, Javad Aminian, Amir-Behghadami, Mehrdad, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Antony, Catherine M., Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arulappan, Judie, Ashraf, Tahira, Athari, Seyyed Shamsadin, Attia, Engi F., Ayele, Meshesha Tsegazeab, Azadnajafabad, Sina, Babu, Abraham Samuel, Bagherieh, Sara, Baltatu, Ovidiu Constantin, Banach, Maciej, Bardhan, Mainak, Barone-Adesi, Francesco, Barrow, Amadou, Basu, Saurav, Bayileyegn, Nebiyou Simegnew, Bensenor, Isabela M., Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhat, Ajay Nagesh, Bhattacharyya, Krittika, Bouaoud, Souad, Braithwaite, Dejana, Brauer, Michael, Butt, Muhammad Hammad, Butt, Zahid A., Calina, Daniela, Cámera, Luis Alberto, Chanie, Gashaw Sisay, Charalampous, Periklis, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chu, Dinh-Toi, Cohen, Aaron J., Cruz-Martins, Natália, Dadras, Omid, Darwesh, Aso Mohammad, Das, Saswati, Debela, Sisay Abebe, Delgado-Ortiz, Laura, Dereje, Diriba, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dirirsa, Gebisa, Doku, Paul Narh, Dongarwar, Deepa, Douiri, Abdel, Dsouza, Haneil Larson, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Mustafa Elagali, Ahmed Elabbas, Elhadi, Muhammed, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faro, Andre, Fatehizadeh, Ali, Fekadu, Ginenus, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Franklin, Richard Charles, Gaal, Peter Andras, Gaihre, Santosh, Gaipov, Abduzhappar, Gebrehiwot, Mesfin, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamiru, Ghafourifard, Mansour, Ghanbari, Reza, Ghashghaee, Ahmad, Gholami, Ali, Gil, Artyom Urievich, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Guadie, Habtamu Alganeh, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hadei, Mostafa, Halwani, Rabih, Hanif, Asif, Hargono, Arief, Harorani, Mehdi, Hartono, Risky Kusuma, Hasani, Hamidreza, Hashi, Abdiwahab, Hay, Simon I., Heidari, Mohammad, Hellemons, Merel E., Herteliu, Claudiu, Holla, Ramesh, Horita, Nobuyuki, Hoseini, Mohammad, Hosseinzadeh, Mehdi, Huang, Junjie, Hussain, Salman, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ibrahim, Sufyan, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Immurana, Mustapha, Ismail, Nahlah Elkudssiah, Merin J, Linda, Jakovljevic, Mihajlo, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jha, Ravi Prakash, Johnson, Olatunji, Joo, Tamas, Joseph, Nitin, Jozwiak, Jacek Jerzy, K, Vaishali, Kaambwa, Billingsley, Kabir, Zubair, Kalankesh, Laleh R., Kalhor, Rohollah, Kandel, Himal, Karanth, Shama D., Karaye, Ibraheem M., Kassa, Bekalu Getnet, Kassie, Gizat M., Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Imteyaz A., Khan, Moien A.B., Khan, Yusra H., Khreis, Haneen, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Knibbs, Luke D., Kolkhir, Pavel, Komaki, Somayeh, Kompani, Farzad, Koohestani, Hamid Reza, Koolivand, Ali, Korzh, Oleksii, Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J., Kumar, Naveen, Kumar, Nithin, Kurmi, Om P., Kuttikkattu, Ambily, La Vecchia, Carlo, Lám, Judit, Lan, Qing, Lasrado, Savita, Latief, Kamaluddin, Lauriola, Paolo, Lee, Sang-woong, Lee, Yo Han, Legesse, Samson Mideksa, Lenzi, Jacopo, Li, Ming-Chieh, Lin, Ro-Ting, Liu, Gang, Liu, Wei, Lo, Chun-Han, Lorenzovici, László, Lu, Yifei, Mahalingam, Soundarya, Mahmoudi, Elham, Mahotra, Narayan B., Malekpour, Mohammad-Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansouri, Borhan, Mathews, Elezebeth, Maulud, Sazan Qadir, Mechili, Enkeleint A., Nasab, Entezar Mehrabi, Menezes, Ritesh G., Mengistu, Dechasa Adare, Mentis, Alexios-Fotios, Meshkat, Mahboobeh, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mirrakhimov, Erkin M., Misganaw, Awoke, Mithra, Prasanna, Moghadasi, Javad, Mohammadi, Esmaeil, Mohammadi, Mokhtar, Mohammadshahi, Marita, Mohammed, Shafiu, Mohan, Syam, Moka, Nagabhishek, Monasta, Lorenzo, Moni, Mohammad Ali, Moniruzzaman, Md, Montazeri, Fateme, Moradi, Maryam, Mostafavi, Ebrahim, Mpundu-Kaambwa, Christine, Murillo-Zamora, Efrén, Murray, Christopher J.L., Nair, Tapas Sadasivan, Nangia, Vinay, Swamy, Sreenivas Narasimha, Narayana, Aparna Ichalangod, Natto, Zuhair S., Nayak, Biswa Prakash, Negash, Wogene Wogene, Nena, Evangelia, Kandel, Sandhya Neupane, Niazi, Robina Khan, Nogueira de Sá, Antonio Tolentino, Nowroozi, Ali, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obaidur, Rahman Md, Odukoya, Oluwakemi Ololade, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T., Bali, Ahmed Omar, Ostojic, Sergej M., A, Mahesh P., Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pahlevan Fallahy, Mohammad Taha, Palicz, Tamás, Pana, Adrian, Park, Eun-Kee, Patel, Jay, Paudel, Rajan, Paudel, Uttam, Pedersini, Paolo, Pereira, Marcos, Pereira, Renato B., Petcu, Ionela-Roxana, Pirestani, Majid, Postma, Maarten J., Prashant, Akila, Rabiee, Mohammad, Radfar, Amir, Rafiei, Sima, Rahim, Fakher, Ur Rahman, Mohammad Hifz, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajput, Prashant, Rana, Juwel, Rao, Chythra R., Rao, Sowmya J., Rashedi, Sina, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Mohamed Redwan, Elrashdy Moustafa, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Nima, Rezaeian, Mohsen, Rodrigues, Mónica, Buendia Rodriguez, Jefferson Antonio, Roever, Leonardo, Rojas-Rueda, David, Rudd, Kristina E., Saad, Aly M.A., Sabour, Siamak, Saddik, Basema, Sadeghi, Erfan, Sadeghi, Masoumeh, Saeed, Umar, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahoo, Harihar, Sajid, Mirza Rizwan, Sakhamuri, Sateesh, Salehi, Sana, Samy, Abdallah M., Santric-Milicevic, Milena M., Sao Jose, Bruno Piassi, Sathian, Brijesh, Satpathy, Maheswar, Saya, Ganesh Kumar, Senthilkumaran, Subramanian, Seylani, Allen, Shahabi, Saeed, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sheikhi, Rahim Ali, Shekhar, Shashank, Sibhat, Migbar Mekonnen, Simpson, Colin R., Singh, Jasvinder A., Singh, Paramdeep, Singh, Surjit, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Soyiri, Ireneous N., Steiropoulos, Paschalis, Stockfelt, Leo, Sun, Jing, Takahashi, Ken, Talaat, Iman M., Tan, Ker-Kan, Tat, Nathan Y., Tat, Vivian Y., Taye, Birhan Tsegaw, Thangaraju, Pugazhenthan, Thapar, Rekha, Thienemann, Friedrich, Tiyuri, Amir, Ngoc Tran, Mai Thi, Tripathy, Jaya Prasad, Car, Lorainne Tudor, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Sana, Vacante, Marco, Valdez, Pascual R., Valizadeh, Rohollah, van Boven, Job F.M., Vasankari, Tommi Juhani, Vaziri, Siavash, Violante, Francesco S., Vo, Bay, Wang, Ning, Wei, Melissa Y., Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Yu, Yong, Yunusa, Ismaeel, Zahir, Mazyar, Zangiabadian, Moein, Zareshahrabadi, Zahra, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zegeye, Zelalem Banjaw, Zhang, Yunquan, Naghavi, Mohsen, Larijani, Bagher, and Farzadfar, Farshad

Published
2023
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38. The state of health in Pakistan and its provinces and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Hafeez, Assad, Dangel, William James, Ostroff, Samuel M, Kiani, Ayyaz Gul, Glenn, Scott D, Abbas, Jaffar, Afzal, Muhammad Sohail, Afzal, Saira, Ahmad, Sajjad, Ahmed, Ali, Ahmed, Haroon, Ali, Liaqat, Ali, Muhammad, Ali, Zahid, Arshad, Muhammad, Ashraf, Tahira, Bhutta, Zulfiqar A, Bibi, Sadia, Butt, Zahid A, Das, Jai K, Fadoo, Zehra, Hanif, Asif, Hayat, Khezar, Humayun, Ayesha, Iqbal, Khalid, Iqbal, Usman, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Malik, Ahmad Azam, Naveed, Muhammad, Naz, Shumaila, Niazi, Robina Khan, Piracha, Zahra Zahid, Saeed, Umar, Salman, Muhammad, Samad, Zainab, Saqib, Muhammad Arif Nadeem, Shah, Syed Mahboob, Shahid, Izza, Shaikh, Masood Ali, Shamshad, Hina, Shuja, Kanwar Hamza, Suleman, Muhammad, Ullah, Anayat, Ullah, Irfan, Ullah, Saif, Ullah, Sana, Waheed, Yasir, Waris, Abdul, Hay, Simon I, Murray, Christopher J L, and Mokdad, Ali H

Published
2023
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41. Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019

Author

Haakenstad, Annie, Yearwood, Jamal Akeem, Fullman, Nancy, Bintz, Corinne, Bienhoff, Kelly, Weaver, Marcia R, Nandakumar, Vishnu, LeGrand, Kate E, Knight, Megan, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abdoli, Amir, Abeldaño Zuñiga, Roberto Ariel, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adetokunboh, Olatunji O, Afzal, Muhammad Sohail, Afzal, Saira, Agudelo-Botero, Marcela, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Ali, Ahmed Rashid, Tarik, Aji, Budi, Akande-Sholabi, Wuraola, Alam, Khurshid, Al Hamad, Hanadi, Alhassan, Robert Kaba, Ali, Liaqat, Alipour, Vahid, Aljunid, Syed Mohamed, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amu, Hubert, Amugsi, Dickson A, Ancuceanu, Robert, Andrade, Pedro Prata, Anjum, Afifa, Arabloo, Jalal, Arab-Zozani, Morteza, Ariffin, Hany, Arulappan, Judie, Aryan, Zahra, Ashraf, Tahira, Atnafu, Desta Debalkie, Atreya, Alok, Ausloos, Marcel, Avila-Burgos, Leticia, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Badiye, Ashish D, Baig, Atif Amin, Bairwa, Mohan, Bakkannavar, Shankar M, Baliga, Shrikala, Banik, Palash Chandra, Bärnighausen, Till Winfried, Barra, Fabio, Barrow, Amadou, Basu, Sanjay, Bayati, Mohsen, Belete, Rebuma, Bell, Arielle Wilder, Bhagat, Devidas S., Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhardwaj, Nikha, Bhaskar, Sonu, Bhattacharyya, Krittika, Bhurtyal, Ashok, Bhutta, Zulfiqar A, Bibi, Sadia, Bijani, Ali, Bikbov, Boris, Biondi, Antonio, Bolarinwa, Obasanjo Afolabi, Bonny, Aime, Brenner, Hermann, Buonsenso, Danilo, Burkart, Katrin, Busse, Reinhard, Butt, Zahid A, Butt, Nadeem Shafique, Caetano dos Santos, Florentino Luciano, Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Cárdenas, Rosario, Carneiro, Vera L A, Catalá-López, Ferrán, Chandan, Joht Singh, Charan, Jaykaran, Chavan, Prachi P, Chen, Simiao, Chen, Shu, Choudhari, Sonali Gajanan, Chowdhury, Enayet Karim, Chowdhury, Mohiuddin Ahsanul Kabir, Cirillo, Massimo, Corso, Barbara, Dadras, Omid, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, Deuba, Keshab, Dhimal, Meghnath, Dhimal, Mandira Lamichhane, Djalalinia, Shirin, Do, Huyen Phuc, Doshmangir, Leila, Duncan, Bruce B, Effiong, Andem, Ehsani-Chimeh, Elham, Elgendy, Islam Y, Elhadi, Muhammed, El Sayed, Iman, El Tantawi, Maha, Erku, Daniel Asfaw, Eskandarieh, Sharareh, Fares, Jawad, Farzadfar, Farshad, Ferrero, Simone, Ferro Desideri, Lorenzo, Fischer, Florian, Foigt, Nataliya A., Foroutan, Masoud, Fukumoto, Takeshi, Gaal, Peter Andras, Gaihre, Santosh, Gardner, William M., Garg, Tushar, Getachew Obsa, Abera, Ghafourifard, Mansour, Ghashghaee, Ahmad, Ghith, Nermin, Gilani, Syed Amir, Gill, Paramjit Singh, Goharinezhad, Salime, Golechha, Mahaveer, Guadamuz, Jenny S., Guo, Yuming, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Vivek Kumar, Gupta, Veer Bala, Hamiduzzaman, Mohammad, Hanif, Asif, Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md. Mehedi, Hasan, M Tasdik, Hashi, Abdiwahab, Hay, Simon I, Hayat, Khezar, Heidari, Mohammad, Heidari, Golnaz, Henry, Nathaniel J, Herteliu, Claudiu, Holla, Ramesh, Hossain, Sahadat, Hossain, Sheikh Jamal, Hossain, Mohammad Bellal Hossain, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hoveidamanesh, Soodabeh, Hsieh, Vivian Chia-rong, Hu, Guoqing, Huang, Junjie, Huda, M Mamun, Ifeagwu, Susan C., Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Rakibul M, Islam, Sheikh Mohammed Shariful, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Itumalla, Ramaiah, Iwagami, Masao, Jahani, Mohammad Ali, Jahanmehr, Nader, Jain, Rajesh, Jakovljevic, Mihajlo, Janodia, Manthan Dilipkumar, Jayapal, Sathish Kumar, Jayaram, Shubha, Jha, Ravi Prakash, Jonas, Jost B., Joo, Tamas, Joseph, Nitin, Jürisson, Mikk, Kabir, Ali, Kalankesh, Leila R, Kalhor, Rohollah, Kamath, Aruna M., Kamenov, Kaloyan, Kandel, Himal, Kantar, Rami S., Kapoor, Neeti, Karanikolos, Marina, Katikireddi, Srinivasa Vittal, Kavetskyy, Taras, Kawakami, Norito, Kayode, Gbenga A., Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khalilov, Rovshan, Khammarnia, Mohammad, Khan, Md Nuruzzaman, Khan, Moien AB, Khan, Maseer, Khezeli, Mehdi, Kim, Min Seo, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Klymchuk, Vitalii, Koly, Kamrun Nahar, Korzh, Oleksii, Kosen, Soewarta, Koul, Parvaiz A, Kuate Defo, Barthelemy, Kumar, G Anil, Kusuma, Dian, Kyu, Hmwe Hmwe, Larsson, Anders O, Lasrado, Savita, Lee, Wei-Chen, Lee, Yo Han, Lee, Chiachi Bonnie, Li, Shanshan, Lucchetti, Giancarlo, Mahajan, Preetam Bhalchandra, Majeed, Azeem, Makki, Alaa, Malekzadeh, Reza, Malik, Ahmad Azam, Malta, Deborah Carvalho, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Martinez-Valle, Adolfo, Martins-Melo, Francisco Rogerlândio, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Maude, Richard James, Maulik, Pallab K, McKee, Martin, Mendoza, Walter, Menezes, Ritesh G, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mirrakhimov, Erkin M, Misganaw, Awoke, Misra, Sanjeev, Moazen, Babak, Mohammadi, Mokhtar, Mohammed, Shafiu, Moitra, Modhurima, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moni, Mohammad Ali, Moradi, Ghobad, Moreira, Rafael Silveira, Mosser, Jonathan F., Mostafavi, Ebrahim, Mouodi, Simin, Nagarajan, Ahamarshan Jayaraman, Nagata, Chie, Naghavi, Mohsen, Nangia, Vinay, Narasimha Swamy, Sreenivas, Narayana, Aparna Ichalangod, Nascimento, Bruno Ramos, Nassereldine, Hasan, Nayak, Biswa Prakash, Nazari, Javad, Negoi, Ionut, Nepal, Samata, Neupane Kandel, Sandhya, Ngunjiri, Josephine W., Nguyen, Huong Lan Thi, Nguyen, Cuong Tat, Ningrum, Dina Nur Anggraini, Noubiap, Jean Jacques, Oancea, Bogdan, Oghenetega, Onome Bright, Oh, In-Hwan, Olagunju, Andrew T, Olakunde, Babayemi Oluwaseun, Omar Bali, Ahmed, Omer, Emad, Onwujekwe, Obinna E, Otoiu, Adrian, Padubidri, Jagadish Rao, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pardhan, Shahina, Pasupula, Deepak Kumar, Pathak, Praveen Kumar, Patton, George C, Pawar, Shrikant, Pereira, Jeevan, Pilania, Manju, Piroozi, Bakhtiar, Podder, Vivek, Pokhrel, Khem Narayan, Postma, Maarten J, Prada, Sergio I, Quazi Syed, Zahiruddin, Rabiee, Navid, Radhakrishnan, Raghu Anekal, Rahman, Md. Mosfequr, Rahman, Mosiur, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahmani, Amir Masoud, Ranabhat, Chhabi Lal, Rao, Chythra R, Rao, Sowmya J, Rasella, Davide, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Renzaho, Andre M.N., Reshmi, Bhageerathy, Resnikoff, Serge, Rezapour, Aziz, Riahi, Seyed Mohammad, Ripon, Rezaul Karim, Sacco, Simona, Sadeghi, Masoumeh, Saeed, Umar, Sahebkar, Amirhossein, Sahiledengle, Biniyam, Sahoo, Harihar, Sahu, Maitreyi, Salama, Joseph S, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M., Sathian, Brijesh, Sawhney, Monika, Schmidt, Maria Inês, Seidu, Abdul-Aziz, Sepanlou, Sadaf G, Seylani, Allen, Shaikh, Masood Ali, Sheikh, Aziz, Shetty, Adithi, Shigematsu, Mika, Shiri, Rahman, Shivakumar, K M, Shokri, Azad, Singh, Jasvinder A., Sinha, Dhirendra Narain, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sofi-Mahmudi, Ahmad, Sousa, Raúl A R C, Stephens, Jacqueline H, Sun, Jing, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tadbiri, Hooman, Tamiru, Animut Tagele, Thankappan, Kavumpurathu Raman, Topor-Madry, Roman, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Tran, Bach Xuan, Tripathi, Niharika, Tripathy, Jaya Prasad, Troeger, Christopher E, Uezono, Deinzel Robles, Ullah, Saif, Ullah, Anayat, Unnikrishnan, Bhaskaran, Vacante, Marco, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasic, Milena, Veroux, Massimiliano, Vervoort, Dominique, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Waheed, Yasir, Wamai, Richard G, Wang, Yuan-Pang, Wang, Yanzhong, Ward, Paul, Wiangkham, Taweewat, Yadav, Lalit, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yi, Siyan, Yiğit, Vahit, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Yunusa, Ismaeel, Zaman, Sojib Bin, Zastrozhin, Mikhail Sergeevich, Zhang, Zhi-Jiang, Zhong, Chenwen, Zuniga, Yves Miel H, Lim, Stephen S, Murray, Christopher J L, and Lozano, Rafael

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2022
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44. Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Author

Peden, Amy E, Cullen, Patricia, Francis, Kate Louise, Moeller, Holger, Peden, Margaret M, Ye, Pengpeng, Tian, Maoyi, Zou, Zhiyong, Sawyer, Susan M, Aali, Amirali, Abbasi-Kangevari, Zeinab, Abbasi-Kangevari, Mohsen, Abdelmasseh, Michael, Abdoun, Meriem, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abebe, Getachew, Abebe, Ayele Mamo, Abedi, Aidin, Abidi, Hassan, Aboagye, Richard Gyan, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adewole, Ololade Grace, Adhikari, Sangeet, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Afolabi, Aanuoluwapo Adeyimika Bachelor, Afzal, Saira, Afzal, Muhammad Sohail, Aghdam, Zahra Babaei, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Tauseef, Ahmad, Sajjad, Ahmadi, Ali, Ahmed, Haroon, Ahmed, Muktar Beshir, Ahmed, Ali, Ahmed, Ayman, Ahmed, Jivan Qasim, Ahmed Rashid, Tarik, Aithala, Janardhana P, Aji, Budi, Akhlaghdoust, Meisam, Alahdab, Fares, Alanezi, Fahad Mashhour, Alemayehu, Astawus, Al Hamad, Hanadi, Ali, Syed Shujait, Ali, Liaqat, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Almidani, Louay, Almustanyir, Sami, Altirkawi, Khalid A, Alvis-Zakzuk, Nelson J, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amir-Behghadami, Mehrdad, Amiri, Sohrab, Amiri, Hoda, Anagaw, Tadele Fentabil, Andrei, Tudorel, Andrei, Catalina Liliana, Anvari, Davood, Anwar, Sumadi Lukman, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Arja, Asrat, Arulappan, Judie, Arumugam, Ashokan, Aryannejad, Armin, Asgary, Saeed, Ashraf, Tahira, Athari, Seyyed Shamsadin, Atreya, Alok, Attia, Sameh, Aujayeb, Avinash, Awedew, Atalel Fentahun, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, Azari, Samad, Azari Jafari, Amirhossein, Azizi, Hosein, Azzam, Ahmed Y, Badiye, Ashish D, Baghcheghi, Nayereh, Bagherieh, Sara, Baig, Atif Amin, Bakkannavar, Shankar M, Balta, Asaminew Birhanu, Banach, Maciej, Banik, Palash Chandra, Bansal, Hansi, Bardhan, Mainak, Barone-Adesi, Francesco, Barrow, Amadou, Bashiri, Azadeh, Baskaran, Pritish, Basu, Saurav, Bayileyegn, Nebiyou Simegnew, Bekel, Abebe Ayalew, Bekele, Alehegn Bekele, Bendak, Salaheddine, Bensenor, Isabela M, Berhie, Alemshet Yirga, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhardwaj, Nikha, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bibi, Sadia, Bintoro, Bagas Suryo, Bitaraf, Saeid, Bodicha, Belay Boda Abule, Boloor, Archith, Bouaoud, Souad, Brown, Julie, Burkart, Katrin, Butt, Nadeem Shafique, Butt, Muhammad Hammad, Cámera, Luis Alberto, Campuzano Rincon, Julio Cesar, Cao, Chao, Carvalho, Andre F, Carvalho, Márcia, Chakraborty, Promit Ananyo, Chandrasekar, Eeshwar K, Chang, Jung-Chen, Charalampous, Periklis, Charan, Jaykaran, Chattu, Vijay Kumar, Chekole, Bitew Mekonnen, Chitheer, Abdulaal, Cho, Daniel Youngwhan, Chopra, Hitesh, Christopher, Devasahayam J, Chukwu, Isaac Sunday, Cruz-Martins, Natália, Dadras, Omid, Dahlawi, Saad M A, Dai, Xiaochen, Damiani, Giovanni, Darmstadt, Gary L, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Das, Saswati, Dastiridou, Anna, Debela, Sisay Abebe, Dehghan, Amin, Demeke, Getnet Makasha, Demetriades, Andreas K, Demissie, Solomon, Dessalegn, Fikadu Nugusu, Desta, Abebaw Alemayehu, Dianatinasab, Mostafa, Diao, Nancy, Dias da Silva, Diana, Diaz, Daniel, Digesa, Lankamo Ena, Diress, Mengistie, Djalalinia, Shirin, Doan, Linh Phuong, Dodangeh, Milad, Doku, Paul Narh, Dongarwar, Deepa, Dsouza, Haneil Larson, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elagali, Ahmed Elabbas Mustafa, Elbahnasawy, Mostafa Ahmed, Elhabashy, Hala Rashad, Elhadi, Muhammed, El Sayed Zaki, Maysaa, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Eskandarieh, Sharareh, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faris, Pawan Sirwan, Farmany, Abbas, Faro, Andre, Farzadfar, Farshad, Fatehizadeh, Ali, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Foroutan, Behzad, Foroutan, Masoud, Fowobaje, Kayode Raphael, Franklin, Richard Charles, Fukumoto, Takeshi, Gaal, Peter Andras, Gadanya, Muktar A, Galali, Yaseen, Galehdar, Nasrin, Ganesan, Balasankar, Garg, Tushar, Gebrehiwot, Mesfin Gebrehiwot Damtew, Gebremariam, Yosef Haile, Gela, Yibeltal Yismaw, Gerema, Urge, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghanbari, Reza, Ghasemi Nour, Mohammad, Gholamalizadeh, Maryam, Gholami, Ali, Gholamrezanezhad, Ali, Ghozy, Sherief, Gilani, Syed Amir, Gill, Tiffany K, Giné-Vázquez, Iago, Girma, Zeleke Abate, Glasbey, James C, Glozah, Franklin N, Golechha, Mahaveer, Goleij, Pouya, Grivna, Michal, Guadie, Habtamu Alganeh, Gunawardane, Damitha Asanga, Guo, Yuming, Gupta, Veer Bala, Gupta, Sapna, Gupta, Bhawna, Gupta, Vivek Kumar, Haj-Mirzaian, Arvin, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hanif, Asif, Hargono, Arief, Harlianto, Netanja I, Harorani, Mehdi, Hasaballah, Ahmed I, Hasan, S M Mahmudul, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J, Hay, Simon I, Heidari, Mohammad, Hendrie, Delia, Heyi, Demisu Zenbaba, Hiraike, Yuta, Holla, Ramesh, Horita, Nobuyuki, Hossain, Sheikh Jamal, Hossain, Mohammad Bellal Hossain, Hosseini Shabanan, Sedighe, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hoveidaei, Amir Human, Hsiao, Alexander Kevin, Hussain, Salman, Hussein, Amal, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Inbaraj, Leeberk Raja, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Islam, Mohammad Mainul, Ismail, Nahlah Elkudssiah, J, Linda Merin, Jahrami, Haitham, Jakovljevic, Mihajlo, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayarajah, Umesh Umesh, Jayaraman, Sudha, Jeganathan, Jayakumar, Jemal, Bedru, Jha, Ravi Prakash, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kadashetti, Vidya, Kadir, Dler Hussein, Kalankesh, Laleh R, Kalankesh, Leila R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kamath, Rajesh, Kandel, Himal, Kantar, Rami S, Kapoor, Neeti, Karami, Hassan, Karaye, Ibraheem M, Karkhah, Samad, Katoto, Patrick DMC, Kauppila, Joonas H, Kayode, Gbenga A, Keikavoosi-Arani, Leila, Keskin, Cumali, Khader, Yousef Saleh, Khajuria, Himanshu, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khan, Maseer, Khan, Yusra H, Khan, Imteyaz A, Khan, Abbas, Khan, Moien AB, Khanali, Javad, Khatatbeh, Moawiah Mohammad, Khayat Kashani, Hamid Reza, Khubchandani, Jagdish, Kifle, Zemene Demelash, Kim, Jihee, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Kneib, Cameron J, Kompani, Farzad, Koohestani, Hamid Reza, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kucuk Bicer, Burcu, Kumar, Nithin, Kumar, Naveen, Kumar, Narinder, Kumar, Manasi, Kurmi, Om P, Laflamme, Lucie, Lám, Judit, Landires, Iván, Larijani, Bagher, Lasrado, Savita, Lauriola, Paolo, La Vecchia, Carlo, Lee, Shaun Wen Huey, Lee, Yo Han, Lee, Sang-woong, Lee, Wei-Chen, Legesse, Samson Mideksa, Li, Shanshan, Lim, Stephen S, Lorenzovici, László, Luke, Amana Ogeto, Madadizadeh, Farzan, Madureira-Carvalho, Áurea M, Magdy Abd El Razek, Muhammed, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Razzagh, Mahmoudimanesh, Marzieh, Majeed, Azeem, Makki, Alaa, Malakan Rad, Elaheh, Malekpour, Mohammad-Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansouri, Borhan, Mansournia, Mohammad Ali, Mathews, Elezebeth, Maulud, Sazan Qadir, Mazingi, Dennis, Mehrabi Nasab, Entezar, Mendoza-Cano, Oliver, Menezes, Ritesh G, Mengistu, Dechasa Adare, Mentis, Alexios-Fotios A, Meretoja, Atte, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Miller, Ted R, Mirghaderi, Seyed Peyman, Mirica, Andreea, Mirmoeeni, Seyyedmohammadsadeq, Mirrakhimov, Erkin M, Mirza, Moonis, Misra, Sanjeev, Mithra, Prasanna, Mittal, Chaitanya, Moberg, Madeline E, Mohammadi, Mokhtar, Mohammadi, Soheil, Mohammadi, Esmaeil, Mohammadpourhodki, Reza, Mohammed, Shafiu, Mohammed, Teroj Abdulrahman, Mohseni, Mohammad, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moreira, Rafael Silveira, Morrison, Shane Douglas, Mostafavi, Ebrahim, Mousavi Isfahani, Haleh, Mubarik, Sumaira, Muccioli, Lorenzo, Mukherjee, Soumyadeep, Mulita, Francesk, Mustafa, Ghulam, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Nangia, Vinay, Nassereldine, Hasan, Natto, Zuhair S, Nayak, Biswa Prakash, Negoi, Ionut, Nejadghaderi, Seyed Aria, Nepal, Samata, Neupane Kandel, Sandhya, Noroozi, Nafise, Nuñez-Samudio, Virginia, Nzoputam, Ogochukwu Janet, Nzoputam, Chimezie Igwegbe, Ochir, Chimedsuren, Odhiambo, Julius Nyerere, Odukoya, Oluwakemi Ololade, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Olagunju, Andrew T, Omar Bali, Ahmed, Omer, Emad, Otoiu, Adrian, Otstavnov, Stanislav S, Otstavnov, Nikita, Oumer, Bilcha, Owolabi, Mayowa O, P A, Mahesh, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pahlevan Fallahy, Mohammad Taha, Palicz, Tamás, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pardhan, Shahina, Park, Eun-Kee, Patel, Sangram Kishor, Pathan, Aslam Ramjan, Pati, Siddhartha, Paudel, Uttam, Pawar, Shrikant, Pedersini, Paolo, Peres, Mario F P, Petcu, Ionela-Roxana, Phillips, Michael R, Pillay, Julian David, Piracha, Zahra Zahid, Poursadeqiyan, Mohsen, Pourtaheri, Naeimeh, Qattea, Ibrahim, Radfar, Amir, Rafiee, Ata, Raghav, Pankaja Raghav, Rahim, Fakher, Rahman, Muhammad Aziz, Rahman, Firman Suryadi, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmani, Shayan, Raj Moolambally, Sheetal, Ramazanu, Sheena, Ramezanzadeh, Kiana, Rana, Juwel, Rao, Chythra R, Rao, Sowmya J, Rashedi, Vahid, Rashidi, Mohammad-Mahdi, Rastogi, Prateek, Rasul, Azad, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Rawassizadeh, Reza, Rezaei, Negar, Rezaei, Nazila, Rezaeian, Mohsen, Rezapour, Aziz, Riad, Abanoub, Riaz, Muhammad, Rickard, Jennifer, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Ronfani, Luca, Roy, Bedanta, S, Manjula, Saad, Aly M A, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Sadeghi, Malihe, Saeb, Mohammad Reza, Saeed, Umar, Saeedi Moghaddam, Sahar, Safi, Sher Zaman, Sahiledengle, Biniyam, Sahoo, Harihar, Sahraian, Mohammad Ali, Saki, Morteza, Salamati, Payman, Salehi, Sana, Salem, Marwa Rashad, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saqib, Muhammad Arif Nadeem, Sarikhani, Yaser, Sarveazad, Arash, Sathian, Brijesh, Satpathy, Maheswar, Saya, Ganesh Kumar, Schneider, Ione Jayce Ceola, Schwebel, David C, Seddighi, Hamed, Senthilkumaran, Subramanian, Seylani, Allen, Shabaninejad, Hosein, Shafeghat, Melika, Shah, Pritik A, Shahabi, Saeed, Shahbandi, Ataollah, Shahraki-Sanavi, Fariba, Shaikh, Masood Ali, Shaker, Elaheh, Shams-Beyranvand, Mehran, Shanawaz, Mohd, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharma, Neeraj, Shashamo, Bereket Beyene, Shayan, Maryam, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shin, Jae Il, Shitaye, Nebiyu Aniley, Shivakumar, K M, Shobeiri, Parnian, Shorofi, Seyed Afshin, Shrestha, Sunil, Siabani, Soraya, Sidemo, Negussie Boti, Simegn, Wudneh, Sinaei, Ehsan, Singh, Paramdeep, Sinto, Robert, Siraj, Md Shahjahan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, S N, Chandan, Socea, Bogdan, Solmi, Marco, Solomon, Yonatan, Song, Yi, Sousa, Raúl A R C, Soyiri, Ireneous N, Stokes, Mark A, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sun, Jing, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabish, Mohammad, Taheri, Ensiyeh, Taheri Soodejani, Moslem, Tampa, Mircea, Tan, Ker-Kan, Tarigan, Ingan Ukur, Tariqujjaman, Md, Tat, Nathan Y, Tat, Vivian Y, Tavakoli, Arash, Tefera, Belay Negash, Tefera, Yibekal Manaye, Temesgen, Gebremaryam, Temsah, Mohamad-Hani, Thangaraju, Pugazhenthan, Thapar, Rekha, Thomas, Nikhil Kenny, Ticoalu, Jansje Henny Vera, Tincho, Marius Belmondo, Tiyuri, Amir, Togtmol, Munkhsaikhan, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Ullah, Sana, Ullah, Saif, Ullah, Irfan, Umakanthan, Srikanth, Unnikrishnan, Bhaskaran, Upadhyay, Era, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasankari, Tommi Juhani, Vaziri, Siavash, Veroux, Massimiliano, Vervoort, Dominique, Violante, Francesco S, Vlassov, Vasily, Vu, Linh Gia, Waheed, Yasir, Wang, Yanzhong, Wang, Yuan-Pang, Wang, Cong, Wiangkham, Taweewat, Wickramasinghe, Nuwan Darshana, Woday, Abay Tadesse, Wu, Ai-Min, Yahya, Gahin Abdulraheem Tayib, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yaya, Sanni, Yigit, Arzu, Yiğit, Vahit, Yisihak, Eshetu, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yunusa, Ismaeel, Yusefi, Hossein, Zahir, Mazyar, Zaman, Sojib Bin, Zare, Iman, Zarea, Kourosh, Zastrozhin, Mikhail Sergeevich, Zhang, Zhi-Jiang, Zhang, Yunquan, Ziapour, Arash, Zodpey, Sanjay, Zoladl, Mohammad, Patton, George C, and Ivers, Rebecca Q

Published
2022
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46. Key wound healing genes as diagnostic biomarkers and therapeutic targets in uterine corpus endometrial carcinoma: an integrated in silico and in vitro study.

Author

Jiang, Fuchuan, Ahmad, Sajjad, kanwal, Sadia, Hameed, Yasir, and Tang, Qian

Subjects
*IMMUNOSTAINING, *LIFE sciences, *GENE expression, *CANCER genetics, *RECEIVER operating characteristic curves
Abstract

Background: Uterine Corpus Endometrial Carcinoma (UCEC) is a prevalent gynecologic malignancy with complex molecular underpinnings. This study identifies key woundhealing genes involved in UCEC and elucidates their roles through a comprehensive analysis. Methods: In silico and in vitro experiments. Results: Seventy wound healing-associated genes were extracted from the Gene Ontology (GO) database, and a protein-protein interaction (PPI) network was constructed using the STRING database. CytoHubba analysis in Cytoscape identified six pivotal hub genes: CD44, FGF2, FGF10, KDM6A, FN1, and MMP2. These genes exhibited significantly lower expression in UCEC cell lines compared to normal controls, as confirmed by RT-qPCR. Receiver Operating Characteristic (ROC) analysis demonstrated their potential as diagnostic biomarkers, with Area Under the Curve (AUC) values ranging from 0.94 to 1.00. Validation using TCGA datasets revealed consistent downregulation of these genes in UCEC samples, corroborated by immunohistochemical staining. Promoter methylation analysis showed significantly higher methylation levels in UCEC, correlating with decreased mRNA expression and poor survival outcomes. Genetic alteration analysis indicated frequent mutations in FN1 and KDM6A, although these did not significantly affect survival. Functional analysis using the CancerSEA database highlighted the involvement of these genes in critical cancer-related processes, including angiogenesis, apoptosis, and metastasis. Immune correlation studies revealed significant associations with immune inhibitor genes and distinct expression patterns across immune subtypes. Overexpression studies in UCEC cell lines demonstrated that CD44 and MMP2 reduce proliferative ability while enhancing migration and wound healing. Conclusion: Collectively, these findings underscore the crucial roles of CD44, FGF2, FGF10, KDM6A, FN1, and MMP2 in UCEC pathogenesis, highlighting their potential as biomarkers and therapeutic targets in this malignancy. [ABSTRACT FROM AUTHOR]

Published
2025
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47. Physicochemical properties and antioxidant potentials of leafy vegetables grown under different agroecological conditions.

Author

Batool, Uzma, Nawaz, Rab, Ahmad, Sajjad, Irfan, Ali, Atif Irshad, Muhammad, Arshad, Muhammad, Mohammad Salamatullah, Ahmad, Noor Shah, Ali, Dauelbait, Musaab, Rehman Butt, Afifa, and Bourhia, Mohammed

Subjects
EDIBLE greens, BRASSICA juncea, VEGETABLE farming, VITAMIN C, SPINACH, FENUGREEK
Abstract

Leafy vegetables are very healthy for human beings having high contents of phyto- and physico-chemicals and are low in fat and calories. Mountainous regions worldwide have diverse agroclimatic conditions conducive for the cultivation of different leafy vegetables. Present research study assessed six leafy vegetables for their composition at fifteen different agroecological sites. Fresh leaves of six leafy vegetables, i.e. alfalfa, water clover, spinach, leaf mustard, pennywort, and fenugreek, were collected from the mountainous region. Procured leaf samples were brought to analytical laboratory and were subjected to physicochemical and phytochemical analysis, i.e. moisture content, pH, TSS, ascorbic acid, carotenoids, phenolic content, flavonoids, and antioxidant potential. Among all the sampling sites and vegetables, a significant variation was observed for the physicochemical and phytochemical parameters. In samples procured from different agroecological sites, the better retention of quality parameters was observed among the leaf sample collected from fifteen different agroecological sites. The highest values were recorded for moisture content in spinach at site 1, for pH in leaf mustard at sites 4, 5 and 6, for TSS in spinach at sites 6 and 9, for ascorbic acid in alfalfa at site 6, for total phenolics in spinach at site 5, for carotenoid in leaf mustard at site 5, for flavonoids in fenugreek at site 5, and for antioxidant in spinach at site 6. It can be concluded that mountainous regions are rich in agroecological conditions suitable for producing leafy vegetables carrying healthful constituents for the consumption by human beings. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Design, Synthesis and Biological Exploration of Novel N -(9-Ethyl-9 H -Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (M pro), Spike Glycoprotein and RdRp.

Author

Zahoor, Ameer Fawad, Munawar, Saba, Ahmad, Sajjad, Iram, Fozia, Anjum, Muhammad Naveed, Khan, Samreen Gul, Javid, Jamila, Nazeer, Usman, and Bhat, Mashooq Ahmad

Abstract

A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency of the synthesized compounds against SARS-CoV-2 was evaluated by enacting molecular docking against its three pivotal proteins, namely, Mpro (main protease; PDB ID: 6LU7), the spike glycoprotein (PDB ID: 6WPT), and RdRp (RNA-dependent RNA polymerase; PDB ID: 6M71). The docking results indicated strong binding affinities between SARS-CoV-2 proteins and the synthesized compounds, which were thereby expected to obstruct the function of SARS proteins. Among the synthesized derivatives, the compounds 9e, 9h, 9i, and 9j exposited the best binding scores of −8.77, −8.76, −8.87, and −8.85 Kcal/mol against Mpro, respectively, −6.69, −6.54, −6.44, and −6.56 Kcal/mol against the spike glycoprotein, respectively, and −7.61, −8.10, −8.01, and −7.54 Kcal/mol against RdRp, respectively. Furthermore, the binding scores of 9b (−8.83 Kcal/mol) and 9c (−8.92 Kcal/mol) against 6LU7 are worth mentioning. Regarding the spike glycoprotein, 9b, 9d, and 9f expressed high binding energies of −6.43, −6.38, and −6.41 Kcal/mol, accordingly. Correspondingly, the binding affinity of 9g (−7.62 Kcal/mol) against RdRp is also noteworthy. Furthermore, the potent compounds were also subjected to ADMET analysis to evaluate their pharmacokinetic properties, suggesting that the compounds 9e, 9h, 9i, and 9j exhibited comparable values. These potent compounds may be selected as inhibitory agents and provide a pertinent context for further investigations. [ABSTRACT FROM AUTHOR]

Published
2024
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