3,448 results on '"A. McIvor"'
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2. DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2
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Bjarnason, Sveinn, McIvor, Jordan A. P., Prestel, Andreas, Demény, Kinga S., Bullerjahn, Jakob T., Kragelund, Birthe B., Mercadante, Davide, and Heidarsson, Pétur O.
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- 2024
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3. Doing research in non-specialist mental health services for children and young people: lessons learnt from a process evaluation of the ICALM (Interpersonal Counselling for Adolescent Low Mood) feasibility randomised controlled trial
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Katangwe-Chigamba, Thando, Murdoch, Jamie, Wilkinson, Paul, Cestaro, Viktoria, Seeley, Carys, Charami-Roupa, Eirini, Clarke, Tim, Dunne, Aoife, Gee, Brioney, Jarrett, Sharon, Laphan, Andrew, McIvor, Susie, Meiser-Stedman, Richard, Rhodes, Thomas, Shepstone, Lee, Turner, David A., and Wilson, Jon
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- 2024
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4. Space
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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5. Introduction
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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6. Language
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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7. Body
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McIvor, Charlotte, Walsh, Ian R, McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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8. Conclusion
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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9. The Celtic Tiger, Inward-Migration and the Peace Process (1994–2008)
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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10. Recession, Commemoration and Covid-19 (2008–2023)
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McIvor, Charlotte, Walsh, Ian R, McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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11. Nation
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McIvor, Charlotte, Walsh, Ian R, McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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12. Rapid Change, Revision and the 'Troubles' (1966–1980)
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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13. Crisis, Uncertainty and Scandal (1980–1994)
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McIvor, Charlotte, Walsh, Ian R., McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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14. Economic Expansion and Moral Conservatism (1957–1966)
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McIvor, Charlotte, Walsh, Ian R, McIvor, Charlotte, and Walsh, Ian R.
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- 2024
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15. Building the capacity of older adults and community: findings from a developmental evaluation of United Way British Columbia’s social prescribing programs for older adults
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Laura Kadowaki, Bobbi Symes, Kahir Lalji, Grace Park, Wynona Giannasi, Jennifer Hystad, and Elayne McIvor
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Medicine (General) ,R5-920 - Abstract
IntroductionOlder adults with higher needs are ideal candidates for social prescribing interventions, given the complex and intersectoral nature of their needs. This article describes findings from a developmental evaluation of 19 social prescribing programs for older adults at risk of frailty. MethodsAn evaluation of the programs was conducted from 2020 to 2023. We used data from three components of the evaluation: (1) initial evaluation data collected in 2020 and 2021; (2) program profiles developed in 2022; and (3) co-creation sessions conducted in 2023. ResultsFrom startup until March 2023, the programs served a total of 2544 older adults. The community connectors identified factors at the individual, interpersonal, institutional, community and policy levels that contributed to the successful implementation and delivery of their programs (e.g. physician champions, communities of practice, strong pre-existing relationships with the health care system), as well as challenges (e.g. limited capacity of family physicians, lack of community resources). There was strong agreement among community connectors that successful social prescribing programs should include the following core elements: (1) making connections to needed community resources; (2) co-creation of a wellness plan with long-term clients or clients who require intensive supports; (3) ongoing follow-up and check-ins for clients with wellness plans; and (4) an assessment and triaging process for the prioritization of clients. ConclusionTo leverage the full potential of social prescribing interventions, it is essential that programs engage with a range of health and social care providers, that community connectors are skilled and well supported, and that adequate investments are made in the nonprofit and voluntary sector.
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- 2024
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16. Renforcer les capacités des aînés et de la collectivité : résultats d’une évaluation de l’élaboration des programmes de prescription sociale conçus par Centraide Colombie-Britannique à l’intention des aînés
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Laura Kadowaki, Bobbi Symes, Kahir Lalji, Grace Park, Wynona Giannasi, Jennifer Hystad, and Elayne McIvor
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Medicine (General) ,R5-920 - Abstract
IntroductionLes aînés ayant des besoins accrus sont des candidats idéaux pour les interventions de prescription sociale, compte tenu de la nature complexe et intersectorielle de leurs besoins. Cet article présente les résultats d’une évaluation de l’élaboration de 19 programmes de prescription sociale destinés aux aînés à risque de fragilité. MéthodologieNous avons effectué une évaluation des programmes pour la période 2020-2023. Nous avons utilisé les données de trois composantes de l’évaluation : 1) les données de l’évaluation initiale, recueillies en 2020 et en 2021, 2) les profils des programmes élaborés en 2022 et 3) les séances de cocréation tenues en 2023. RésultatsDe leur lancement jusqu’au mois de mars 2023, les programmes ont servi 2 544 aînés. Les agents de liaison communautaire ont cerné les facteurs au niveau individuel, au niveau interpersonnel, au niveau des établissements, au niveau de la collectivité et au niveau des politiques qui ont contribué à la mise en oeuvre et à la prestation de leurs programmes (médecins champions, communautés de pratique, solides relations préexistantes avec le système de santé, etc.), de même que les difficultés qui ont été rencontrées (capacité limitée des médecins de famille, manque de ressources communautaires, etc.). Les agents de liaison communautaire ont convenu qu’un programme de prescription sociale efficace devrait comprendre les éléments essentiels suivants : 1) établir des liens avec les ressources communautaires nécessaires, 2) prévoir la cocréation d’un plan de mieux-être avec les clients ayant besoin d’un soutien de longue durée ou intensif, 3) assurer un suivi et des vérifications de façon continuelle dans le cas des clients ayant des plans de mieux-être et 4) prévoir un processus d’évaluation et de triage pour la priorisation des clients. ConclusionPour tirer pleinement parti des possibilités offertes par les interventions de prescription sociale, il est essentiel que les programmes mobilisent un éventail de fournisseurs de soins de santé et de services sociaux, que les agents de liaison communautaire soient qualifiés et bien appuyés et que des investissements adéquats soient faits dans le secteur des organismes à but non lucratif et du bénévolat.
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- 2024
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17. Mark-recapture validates the use of photo-identification for the widely distributed blue-spotted ribbontail ray, Taeniura lymma
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Ashlie J. McIvor, Collin T. Williams, Walter A. Rich, Anna M. Knochel, Neil M. Burns, and Michael L. Berumen
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Medicine ,Science - Abstract
Abstract The ability to identify individual animals can provide valuable insights into the behaviour, life history, survivorship, and demographics of wild populations. Photo-identification (photo-ID) uses unique natural markings to identify individuals and can be effective for scalable and non-invasive research on marine fauna. The successful application of photo-ID requires that chosen distinguishing markings are unique to individuals and persist over time. In this study, we validate the use of dorsal spot patterns for identifying individual blue-spotted ribbontail rays (Taeniura lymma) in conjunction with traditional tagging methods. Spot patterns were unique among T. lymma with 90.3% of individuals correctly identified using I3S photo-matching software from images taken up to 496 days apart. In comparison, traditional physical tagging methods showed a tag loss rate of 27% and a maximum tag retention period of only 356 days. Our findings demonstrate the effectiveness of photo-ID as a tool to monitor populations and better understand the ecology of the blue-spotted ribbontail ray without the need for physical tagging. The validation of photo-ID for this widespread species is important as it enables behavioural and demographic changes to be easily tracked in relation to coastal threats such as human development and habitat degradation.
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- 2024
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18. Stratified analyses refine association between TLR7 rare variants and severe COVID-19
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Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca V.C. Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J. Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustín Albillos, Jesus M. Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Joachim L. Schultze, Olaf Riess, Andre Franke, Konrad Rawlik, David Ellinghaus, Alexander Hoischen, Axel Schmidt, Kerstin U. Ludwig, Valeria Rimoldi, Elvezia M. Paraboschi, Alessandra Bandera, Flora Peyvandi, Giacomo Grasselli, Francesco Blasi, Francesco Malvestiti, Serena Pelusi, Cristiana Bianco, Lorenzo Miano, Angela Lombardi, Pietro Invernizzi, Alessio Gerussi, Giuseppe Citerio, Andrea Biondi, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Giuseppe Foti, Ilaria Beretta, Mariella D'Angiò, Laura Rachele Bettini, Xavier Farré, Susana Iraola-Guzmán, Manolis Kogevinas, Gemma Castaño-Vinyals, Koldo Garcia-Etxebarria, Beatriz Nafria, Mauro D'Amato, Adriana Palom, Colin Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian Knight, Lowell Ling, David Maslove, Danny McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter J.M. Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar-Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard Clark, Audrey Coutts, Judy Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Fineran, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, Rachel Law, Sarah Law, Rebecca Lidstone-Scott, Louise Macgillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Owen Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Christopher Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, Christopher Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jeronimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Kumar Rohit, Frater Alasdair, Malik Saleem, Carter David, Jenkins Samuel, Zoe Lamond, Wall Alanna, Jaime Fernandez-Roman, David O. Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia A.C. Waite, Victoria Waugh, Ingeborg D. Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O'Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andres Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sohphie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Ceri Battle, Elaine Brinkworth, Rachel Harford, Carl Murphy, Luke Newey, Tabitha Rees, Marie Williams, Sophie Arnold, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Lina Grauslyte, Musarat Hussain, Mandeep Phull, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Laura Ortiz-Ruiz de Gordoa, Emily Peasgood, Claire Phillips, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, James Scriven, Carlos Castro Delgado, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Sarah Farnell-Ward, Abiola Harrison, Rebecca Kanu, Susannah Leaver, Elena Maccacari, Soumendu Manna, Romina Pepermans Saluzzio, Joana Queiroz, Tinashe Samakomva, Christine Sicat, Joana Texeira, Edna Fernandes Da Gloria, Ana Lisboa, John Rawlins, Jisha Mathew, Ashley Kinch, William James Hurt, Nirav Shah, Victoria Clark, Maria Thanasi, Nikki Yun, Kamal Patel, Sara Bennett, Emma Goodwin, Matthew Jackson, Alissa Kent, Clare Tibke, Wiesia Woodyatt, Ahmed Zaki, Azmerelda Abraheem, Peter Bamford, Kathryn Cawley, Charlie Dunmore, Maria Faulkner, Rumanah Girach, Helen Jeffrey, Rhianna Jones, Emily London, Imrun Nagra, Farah Nasir, Hannah Sainsbury, Clare Smedley, Tahera Patel, Matthew Smith, Srikanth Chukkambotla, Aayesha Kazi, Janice Hartley, Joseph Dykes, Muhammad Hijazi, Sarah Keith, Meherunnisa Khan, Janet Ryan-Smith, Philippa Springle, Jacqueline Thomas, Nick Truman, Samuel Saad, Dabheoc Coleman, Christopher Fine, Roseanna Matt, Bethan Gay, Jack Dalziel, Syamlan Ali, Drew Goodchild, Rhiannan Harling, Ravi Bhatterjee, Wendy Goddard, Chloe Davison, Stephen Duberly, Jeanette Hargreaves, Rachel Bolton, Miriam Davey, David Golden, Rebecca Seaman, Shiney Cherian, Sean Cutler, Anne Emma Heron, Anna Roynon-Reed, Tamas Szakmany, Gemma Williams, Owen Richards, Yusuf Cheema, Hollie Brooke, Sarah Buckley, Jose Cebrian Suarez, Ruth Charlesworth, Karen Hansson, John Norris, Alice Poole, Alastair Rose, Rajdeep Sandhu, Brendan Sloan, Elizabeth Smithson, Muthu Thirumaran, Veronica Wagstaff, Alexandra Metcalfe, Mark Brunton, Jess Caterson, Holly Coles, Matthew Frise, Sabi Gurung Rai, Nicola Jacques, Liza Keating, Emma Tilney, Shauna Bartley, Parminder Bhuie, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Bryan Yates, Jessica Reynolds, Helen Campbell, Maria Thompsom, Steve Dodds, Stacey Duffy, Sandra Greer, Karen Shuker, Ascanio Tridente, Reena Khade, Ashok Sundar, George Tsinaslanidis, Isobel Birkinshaw, Joseph Carter, Kate Howard, Joanne Ingham, Rosie Joy, Harriet Pearson, Samantha Roche, Zoe Scott, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, Maria Croft, Ian White, Victoria Frost, Maia Aquino, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Christine Almaden-Boyle, Pauline Austin, Louise Cabrelli, Stephen Cole, Matt Casey, Susan Chapman, Clare Whyte, Yolanda Baird, Aaron Butler, Indra Chadbourn, Linda Folkes, Heather Fox, Amy Gardner, Raquel Gomez, Gillian Hobden, Luke Hodgson, Kirsten King, Michael Margarson, Tim Martindale, Emma Meadows, Dana Raynard, Yvette Thirlwall, David Helm, Jordi Margalef, Kristine Criste, Rebecca Cusack, Kim Golder, Hannah Golding, Oliver Jones, Samantha Leggett, Michelle Male, Martyna Marani, Kirsty Prager, Toran Williams, Belinda Roberts, Karen Salmon, Peter Anderson, Katie Archer, Karen Austin, Caroline Davis, Alison Durie, Olivia Kelsall, Jessica Thrush, Charlie Vigurs, Laura Wild, Hannah-Louise Wood, Helen Tranter, Alison Harrison, Nicholas Cowley, Michael McAlindon, Andrew Burtenshaw, Stephen Digby, Emma Low, Aled Morgan, Naiara Cother, Tobias Rankin, Sarah Clayton, Alex McCurdy, Cecilia Ahmed, Balvinder Baines, Sarah Clamp, Julie Colley, Risna Haq, Anne Hayes, Jonathan Hulme, Samia Hussain, Sibet Joseph, Rita Kumar, Zahira Maqsood, Manjit Purewal, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Jason Cupitt, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Bethan Deacon, Ceri Lynch, Carla Pothecary, Lisa Roche, Gwenllian Sera Howe, Jayaprakash Singh, Keri Turner, Hannah Ellis, Natalie Stroud, Jodie Hunt, Joy Dearden, Emma Dobson, Andy Drummond, Michelle Mulcahy, Sheila Munt, Grainne O'Connor, Jennifer Philbin, Chloe Rishton, Redmond Tully, Sarah Winnard, Susanne Cathcart, Katharine Duffy, Alex Puxty, Kathryn Puxty, Lynne Turner, Jane Ireland, Gary Semple, Kate Long, Simon Whiteley, Elizabeth Wilby, Bethan Ogg, Amanda Cowton, Andrea Kay, Melanie Kent, Kathryn Potts, Ami Wilkinson, Suzanne Campbell, Ellen Brown, Julie Melville, Jay Naisbitt, Rosane Joseph, Maria Lazo, Olivia Walton, Alan Neal, Peter Alexander, Schvearn Allen, Joanne Bradley-Potts, Craig Brantwood, Jasmine Egan, Timothy Felton, Grace Padden, Luke Ward, Stuart Moss, Susannah Glasgow, Lynn Abel, Michael Brett, Brian Digby, Lisa Gemmell, James Hornsby, Patrick MacGoey, Pauline O'Neil, Richard Price, Natalie Rodden, Kevin Rooney, Radha Sundaram, Nicola Thomson, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Charlotte Downes, Kathleen Holding, Katie Riches, Mary Hilton, Mel Hayman, Deepak Subramanian, Priya Daniel, Oluronke Adanini, Nikhil Bhatia, Maines Msiska, Rebecca Collins, Ian Clement, Bijal Patel, A. Gulati, Carole Hays, K. Webster, Anne Hudson, Andrea Webster, Elaine Stephenson, Louise McCormack, Victoria Slater, Rachel Nixon, Helen Hanson, Maggie Fearby, Sinead Kelly, Victoria Bridgett, Philip Robinson, Julie Camsooksai, Charlotte Humphrey, Sarah Jenkins, Henrik Reschreiter, Beverley Wadams, Yasmin Death, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Gillian Bell, Katy English, Amro Katary, Louise Wilcox, Michelle Bruce, Karen Connolly, Tracy Duncan, Helen T-Michael, Gabriella Lindergard, Samuel Hey, Claire Fox, Jordan Alfonso, Laura Jayne Durrans, Jacinta Guerin, Bethan Blackledge, Jade Harris, Martin Hruska, Ayaa Eltayeb, Thomas Lamb, Tracey Hodgkiss, Lisa Cooper, Joanne Rothwell, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Liana Lankester, Nikitas Nikitas, Colin Wells, Bethan Stowe, Kayleigh Spencer, Craig Brandwood, Lara Smith, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Elena Apetri, Cathrine Basikolo, Laura Catlow, Bethan Charles, Paul Dark, Reece Doonan, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Tracey Cosier, Gemma Millen, Neil Richardson, Natasha Schumacher, Heather Weston, James Rand, Nicola Baxter, Steven Henderson, Sophie Kennedy-Hay, Christopher McParland, Laura Rooney, Malcolm Sim, Gordan McCreath, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Jeremy Bewley, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Rebekah Johnson, Katie Sweet, Denise Webster, Georgia Efford, Karen Convery, Deirdre Fottrell-Gould, Lisa Hudig, Jocelyn Keshet-Price, Georgina Randell, Katie Stammers, Maria Bokhari, Vanessa Linnett, Rachael Lucas, Wendy McCormick, Jenny Ritzema, Amanda Sanderson, Helen Wild, Anthony Rostron, Alistair Roy, Lindsey Woods, Sarah Cornell, Fiona Wakinshaw, Kimberley Rogerson, Jordan Jarmain, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Georgia Bercades, David Brealey, Ingrid Hass, Niall MacCallum, Gladys Martir, Eamon Raith, Anna Reyes, Deborah Smyth, Letizia Zitter, Sarah Benyon, Suzie Marriott, Linda Park, Samantha Keenan, Elizabeth Gordon, Helen Quinn, Kizzy Baines, Lenka Cagova, Adama Fofano, Lucie Garner, Helen Holcombe, Sue Mepham, Alice Michael Mitchell, Lucy Mwaura, Krithivasan Praman, Alain Vuylsteke, Julie Zamikula, Bally Purewal, Vanessa Rivers, Stephanie Bell, Hayley Blakemore, Borislava Borislavova, Beverley Faulkner, Emma Gendall, Elizabeth Goff, Kati Hayes, Matt Thomas, Ruth Worner, Kerry Smith, Deanna Stephens, Louise Mew, Esther Mwaura, Richard Stewart, Felicity Williams, Lynn Wren, Sara-Beth Sutherland, Emily Bevan, Jane Martin, Dawn Trodd, Geoff Watson, Caroline Wrey Brown, Amy Collins, Waqas Khaliq, Estefania Treus Gude, Olugbenga Akinkugbe, Alasdair Bamford, Emily Beech, Holly Belfield, Michael Bell, Charlene Davies, Gareth A.L. Jones, Tara McHugh, Hamza Meghari, Lauran O'Neill, Mark J. Peters, Samiran Ray, Ana Luisa Tomas, Iona Burn, Geraldine Hambrook, Katarina Manso, Ruth Penn, Pradeep Shanmugasundaram, Julie Tebbutt, Danielle Thornton, Jade Cole, Rhys Davies, Donna Duffin, Helen Hill, Ben Player, Emma Thomas, Angharad Williams, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Reni Jacob, Cathy Jones, Craig Denmade, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Patricia Doble, Joanne Hutter, Corinne Pawley, Charmaine Shovelton, Marius Vaida, Deborah Butcher, Susie O'Sullivan, Nicola Butterworth-Cowin, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Gary H. 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SARS-CoV-2 ,host genetics ,toll-like receptor 7 ,targeted sequencing ,rare variants ,variant collapsing analysis ,Genetics ,QH426-470 - Abstract
Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (
- Published
- 2024
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19. Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID
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Omer Elneima, John R. Hurst, Carlos Echevarria, Jennifer K. Quint, Samantha Walker, Salman Siddiqui, Petr Novotny, Paul E. Pfeffer, Jeremy S. Brown, Manu Shankar-Hari, Hamish J.C. McAuley, Olivia C. Leavy, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Matthew Richardson, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Rachael A. Evans, Louise V. Wain, Aziz Sheikh, Chris E. Brightling, Anthony De Soyza, Liam G. Heaney, J.K. Baillie, N.I. Lone, E. Pairo-Castineira, N. Avramidis, K. Rawlik, S Jones, L. Armstrong, B. Hairsine, H. Henson, C. Kurasz, A. Shaw, L. Shenton, H. Dobson, A. Dell, S. Fairbairn, N. Hawkings, J. Haworth, M. Hoare, V. Lewis, A. Lucey, G. Mallison, H. Nassa, C. Pennington, A. Price, C. Price, A. Storrie, G. Willis, S. Young, K. Poinasamy, S. Walker, I. Jarrold, A. Sanderson, K. Chong-James, C. David, W.Y. James, P. Pfeffer, O. Zongo, A. Martineau, C. Manisty, C. Armour, V. Brown, J. Busby, B. Connolly, T. Craig, S. Drain, L.G. Heaney, B. King, N. Magee, E. Major, D. McAulay, L. McGarvey, J. McGinness, T. Peto, R. Stone, A. Bolger, F. Davies, A. Haggar, J. Lewis, A. Lloyd, R. Manley, E. McIvor, D. Menzies, K. Roberts, W. Saxon, D. Southern, C. Subbe, V. Whitehead, A. Bularga, N.L. Mills, J. Dawson, H. El-Taweel, L. Robinson, L. Brear, K. Regan, D. Saralaya, K. Storton, S. Amoils, A. Bermperi, I. Cruz, K. Dempsey, A. Elmer, J. Fuld, H. Jones, S. Jose, S. Marciniak, M. Parkes, C. Ribeiro, J. Taylor, M. Toshner, L. Watson, J. Worsley, L. Broad, T. Evans, M. Haynes, L. Jones, L. Knibbs, A. McQueen, C. Oliver, K. Paradowski, R. Sabit, J. Williams, I. Jones, L. Milligan, E. Harris, C. Sampson, E. Davies, C. Evenden, A. Hancock, K. Hancock, C. Lynch, M. Rees, L. Roche, N. Stroud, T. Thomas-Woods, S. Heller, T. Chalder, K. Shah, E. Robertson, B. Young, M. Babores, M. 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Spencer, B. Vinson, M. Ashworth, K. Abel, H. Chinoy, B. Deakin, M. Harvie, C.A. Miller, S. Stanel, P. Barran, D. Trivedi, H. McAllister-Williams, S. Paddick, A. Rostron, J.P. Taylor, D. Baguley, C. Coleman, E. Cox, L. Fabbri, S. Francis, I. Hall, E. Hufton, S. Johnson, F. Khan, P. Kitterick, R. Morriss, N. Selby, L. Wright, C. Antoniades, A. Bates, M. Beggs, K. Bhui, K. Breeze, K.M. Channon, D. Clark, X. Fu, M. Husain, X. Li, E. Lukaschuk, C. McCracken, K. McGlynn, R. Menke, K. Motohashi, T.E. Nichols, G. Ogbole, S. Piechnik, I. Propescu, J. Propescu, A.A. Samat, Z.B. Sanders, L. Sigfrid, M. Webster, L. Kingham, P. Klenerman, H. Lamlum, G. Carson, M. Taquet, L. Finnigan, L.C. Saunders, J.M. Wild, P.C. Calder, N. Huneke, G. Simons, D. Baldwin, S. Bain, L. Daines, E. Bright, P. Crisp, R. Dharmagunawardena, M. Stern, L. Bailey, A. Reddington, A. Wight, A. Ashish, J. Cooper, E. Robinson, A. Broadley, L. Barman, C. Brookes, K. Elliott, L. Griffiths, Z. Guy, K. Howard, D. Ionita, H. Redfearn, C. Sarginson, and A. Turnbull
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Medicine - Abstract
Background The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown. Methods Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group. Results A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, p
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- 2024
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20. Long COVID and cardiovascular disease: a prospective cohort study
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Amitava Banerjee, Jennifer Kathleen Quint, Linzy Houchen-Wolloff, S Thomas, Kamlesh Khunti, Naveed Sattar, J Breeze, Michael Marks, S Johnson, D Smith, C Wright, Colin Berry, Matthew Richardson, Ling-Pei Ho, C Tong, Amisha Singapuri, J Chen, Gerry P McCann, J Cole, X Li, J Greenwood, S Plein, A Brown, J Smith, J Brown, M Brown, J Lewis, A Young, Nicholas L Mills, A Banerjee, R Hughes, C King, L Osborne, S Jones, A Wilson, R Francis, Stefan Neubauer, D Wilkinson, P Marino, N Hart, G Kaltsakas, Alastair James Moss, Betty Raman, John Greenwood, F Khan, J Martin, S Smith, A Casey, A Sheikh, P Carter, T Thompson, B Patel, N Rahman, C Coleman, N Smith, B Williams, K Turner, D Lee, S Barratt, J Williams, L Jones, A Smith, A Gupta, R Reddy, S White, N Williams, A Michael, V Turner, H Evans, L Hall, C Lawson, J Hughes, H Gordon, C Dawson, A Ford, J Simpson, C Bloomfield, E Lee, A Taylor, D Anderson, J Clarke, S Turner, K Shaw, P Shah, S Misra, J Evans, H Jones, M Ali, A Arias, C Dupont, A 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Wolf-Roberts, S Anifowose, E Calvelo, D Copeland, L Evison, T Fayzan, K March, M Mariveles, L McLeavey, S Moriera, U Munawar, J Nunag, U Nwanguma, L Orriss- Dib, J Schronce, L Tarusan, N Yasmin, A-M Guerdette, K Warwick, R Adrego, H Assefa-Kebede, P Dulawan, A Knighton, M Malim, S Patale, K Shevket, A Te, C Favager, J Rangeley, B Whittam, N Window, L Allerton, AM All, A Berridge, S L Dobson, K Hainey, V Highett, S Kaprowska, AL Key, S Koprowska, G Madzamba, F Malein, C Mears, L Melling, M J Noonan, L Poll, K A Tripp, B Vinson, L O Wajero, S A Williams-Howard, J Wyles, S N Diwanji, P Papineni, S Quaid, G F Tiongson, P Barran, J Blaikely, N Choudhury, Z Kausar, N Odell, R Osbourne, S Stockdale, P Hogarth, L Gilmour, R Hamil, K Leitch, L Macliver, B Welsh, S Clohisey, A Deans, J Furniss, C Deas, A R Solstice, C J Tee, S Waterson, T Light, M Chrystal, W Jang, S Linford, R Needham, A Nikolaidis, S Prosper, A Bloss, M Cassar, F Conneh, M Havinden-Williams, P Kurupati, C Megson, K Motohashi, G Ogg, E Pacpaco, J Propescu, E Tunnicliffe, D Cristiano, N Dormand, M Gummadi, D Matila, O Olaosebikan, L Garner, J Pack, K Paques, NDiar Bakerly, D Holgate, N Mairs, L McMorrow, J Oxton, J Pendlebury, C Summersgill, R Ugwuoke, W Matimba-Mupaya, S Strong-Sheldrake, J Bagshaw, K Birchall, H Carborn, L Chetham, Z Coburn, J Finnigan, H Foot, D Foote, L Haslam, L Hesselden, A Holbourn, B Holroyd- Hind, E Hurditch, F Ilyas, C Jarman, R Lenagh, A Lye, I Macharia, A Mbuyisa, S Megson, J Meiring, H Newell, L Nwafor, D Pattenadk, P Ravencroft, C Roddis, J Sidebottom, N Steele, R Stimpson, B Thamu, N Tinker, N Msimanga, M Mencias, T Samakomva, V Tavoukjian, C Goodwin, M Greatorex, W Lovegrove, TA Sewell, D Sissons, D Sowter, V Whitworth, L Warburton, T Wainwright, J Tilley, L Connor, M Coulding, S Kilroy, H Savill, J Vere, E Fraile, J Ugoji, H Lota, G Landers, M Nasseri, S Portukhay, J Ingham, M Chablani, N Ahwireng, B Bang, R Jastrub, M Merida Morillas, H Plant, N Ahmad Haider, R Baggott, A Botkai, J Dasgin, K Draxlbauer, T Hiwot, V Kamwa, K Mcgee, A Neal, A Newton Cox, J Nyaboko, Z Peterkin, Z Suleiman, S Walder, S Yasmin, K P Yip, M Aljaroof, M Bakau, M Bingham, A Charalambou, B Gootpu, K Hadley, P McCourt, A Prickett, I N Qureshi, T J C Ward, E Marouzet, T Sass, E Bright, A Reddington, L Barman, Z Guy, and D Ionita
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.Trail registration number ISRCTN10980107.
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- 2024
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21. Lentiviral Gene Therapy for Artemis-Deficient SCID
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Cowan, Morton J, Yu, Jason, Facchino, Janelle, Fraser-Browne, Carol, Sanford, Ukina, Kawahara, Misako, Dara, Jasmeen, Long-Boyle, Janel, Oh, Jess, Chan, Wendy, Chag, Shivali, Broderick, Lori, Chellapandian, Deepak, Decaluwe, Hélène, Golski, Catherine, Hu, Diana, Kuo, Caroline Y, Miller, Holly K, Petrovic, Aleksandra, Currier, Robert, Hilton, Joan F, Punwani, Divya, Dvorak, Christopher C, Malech, Harry L, McIvor, R Scott, and Puck, Jennifer M
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Medical Biotechnology ,Biomedical and Clinical Sciences ,Hematology ,Transplantation ,Regenerative Medicine ,Gene Therapy ,Biotechnology ,Pediatric ,Genetics ,Vaccine Related ,6.2 Cellular and gene therapies ,5.2 Cellular and gene therapies ,Evaluation of treatments and therapeutic interventions ,Development of treatments and therapeutic interventions ,Inflammatory and immune system ,Good Health and Well Being ,Humans ,Infant ,Busulfan ,Genetic Therapy ,Immunoglobulin M ,Severe Combined Immunodeficiency ,DNA Repair Enzymes ,Antigens ,CD34 ,Transplantation ,Autologous ,Lentivirus ,Genetic Vectors ,T-Lymphocytes ,B-Lymphocytes ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundThe DNA-repair enzyme Artemis is essential for rearrangement of T- and B-cell receptors. Mutations in DCLRE1C, which encodes Artemis, cause Artemis-deficient severe combined immunodeficiency (ART-SCID), which is poorly responsive to allogeneic hematopoietic-cell transplantation.MethodsWe carried out a phase 1-2 clinical study of the transfusion of autologous CD34+ cells, transfected with a lentiviral vector containing DCLRE1C, in 10 infants with newly diagnosed ART-SCID. We followed them for a median of 31.2 months.ResultsMarrow harvest, busulfan conditioning, and lentiviral-transduced CD34+ cell infusion produced the expected grade 3 or 4 adverse events. All the procedures met prespecified criteria for feasibility at 42 days after infusion. Gene-marked T cells were detected at 6 to 16 weeks after infusion in all the patients. Five of 6 patients who were followed for at least 24 months had T-cell immune reconstitution at a median of 12 months. The diversity of T-cell receptor β chains normalized by 6 to 12 months. Four patients who were followed for at least 24 months had sufficient B-cell numbers, IgM concentration, or IgM isohemagglutinin titers to permit discontinuation of IgG infusions. Three of these 4 patients had normal immunization responses, and the fourth has started immunizations. Vector insertion sites showed no evidence of clonal expansion. One patient who presented with cytomegalovirus infection received a second infusion of gene-corrected cells to achieve T-cell immunity sufficient for viral clearance. Autoimmune hemolytic anemia developed in 4 patients 4 to 11 months after infusion; this condition resolved after reconstitution of T-cell immunity. All 10 patients were healthy at the time of this report.ConclusionsInfusion of lentiviral gene-corrected autologous CD34+ cells, preceded by pharmacologically targeted low-exposure busulfan, in infants with newly diagnosed ART-SCID resulted in genetically corrected and functional T and B cells. (Funded by the California Institute for Regenerative Medicine and the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT03538899.).
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- 2022
22. Intrathecal or intravenous AAV9-IDUA/RGX-111 at minimal effective dose prevents cardiac, skeletal and neurologic manifestations of murine MPS I
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Belur, Lalitha R., Huber, Avery K., Mantone, Hillary, Robertson, Mason, Smith, Miles C., Karlen, Andrea D., Kitto, Kelley F., Ou, Li, Whitley, Chester B., Braunlin, Elizabeth, Furcich, Justin, Lund, Troy C., Seelig, Davis, Fairbanks, Carolyn A., Buss, Nicholas, Kim, Kwi Hye, and McIvor, R. Scott
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- 2024
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23. Stratified analyses refine association between TLR7 rare variants and severe COVID-19
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Rimoldi, Valeria, Paraboschi, Elvezia M., Bandera, Alessandra, Peyvandi, Flora, Grasselli, Giacomo, Blasi, Francesco, Malvestiti, Francesco, Pelusi, Serena, Bianco, Cristiana, Miano, Lorenzo, Lombardi, Angela, Invernizzi, Pietro, Gerussi, Alessio, Citerio, Giuseppe, Biondi, Andrea, Valsecchi, Maria Grazia, Cazzaniga, Marina Elena, Foti, Giuseppe, Beretta, Ilaria, D'Angiò, Mariella, Bettini, Laura Rachele, Farré, Xavier, Iraola-Guzmán, Susana, Kogevinas, Manolis, Castaño-Vinyals, Gemma, Garcia-Etxebarria, Koldo, Nafria, Beatriz, D'Amato, Mauro, Palom, Adriana, Begg, Colin, Clohisey, Sara, Hinds, Charles, Horby, Peter, Knight, Julian, Ling, Lowell, Maslove, David, McAuley, Danny, Millar, Johnny, Montgomery, Hugh, Nichol, Alistair, Openshaw, Peter J.M., Pereira, Alexandre C., Ponting, Chris P., Rowan, Kathy, Semple, Malcolm G., Shankar-Hari, Manu, Summers, Charlotte, Walsh, Timothy, Baillie, J. Kenneth, Aravindan, Latha, Armstrong, Ruth, Biggs, Heather, Boz, Ceilia, Brown, Adam, Clark, Richard, Coutts, Audrey, Coyle, Judy, Cullum, Louise, Das, Sukamal, Day, Nicky, Donnelly, Lorna, Duncan, Esther, Fawkes, Angie, Fineran, Paul, Fourman, Max Head, Furlong, Anita, Furniss, James, Gallagher, Bernadette, Gilchrist, Tammy, Golightly, Ailsa, Griffiths, Fiona, Hafezi, Katarzyna, Hamilton, Debbie, Hendry, Ross, Law, Andy, Law, Dawn, Law, Rachel, Law, Sarah, Lidstone-Scott, Rebecca, Macgillivray, Louise, Maclean, Alan, Mal, Hanning, McCafferty, Sarah, Mcmaster, Ellie, Meikle, Jen, Moore, Shona C., Morrice, Kirstie, Murphy, Lee, Murphy, Sheena, Hellen, Mybaya, Oosthuyzen, Wilna, Zheng, Chenqing, Chen, Jiantao, Parkinson, Nick, Paterson, Trevor, Schon, Katherine, Stenhouse, Andrew, Das, Mihaela, Swets, Maaike, Szoor-McElhinney, Helen, Taneski, Filip, Turtle, Lance, Wackett, Tony, Ward, Mairi, Weaver, Jane, Wrobel, Nicola, Zechner, Marie, Arbane, Gill, Bociek, Aneta, Campos, Sara, Grau, Neus, Jones, Tim Owen, Lim, Rosario, Marotti, Martina, Ostermann, Marlies, Whitton, Christopher, Alldis, Zoe, Astin-Chamberlain, Raine, Bibi, Fatima, Biddle, Jack, Blow, Sarah, Bolton, Matthew, Borra, Catherine, Bowles, Ruth, Burton, Maudrian, Choudhury, Yasmin, Collier, David, Cox, Amber, Easthope, Amy, Ebano, Patrizia, Fotiadis, Stavros, Gurasashvili, Jana, Halls, Rosslyn, Hartridge, Pippa, Kallon, Delordson, Kassam, Jamila, Lancoma-Malcolm, Ivone, Matharu, Maninderpal, May, Peter, Mitchelmore, Oliver, Newman, Tabitha, Patel, Mital, Pheby, Jane, Pinzuti, Irene, Prime, Zoe, Prysyazhna, Oleksandra, Shiel, Julian, Taylor, Melanie, Tierney, Carey, Wood, Suzanne, Zak, Anne, Zongo, Olivier, Bonner, Stephen, Hugill, Keith, Jones, Jessica, Liggett, Steven, Headlam, Evie, Bandla, Nageswar, Gellamucho, Minnie, Davies, Michelle, Thompson, Christopher, Abdelrazik, Marwa, Bakthavatsalam, Dhanalakshmi, Elhassan, Munzir, Ganesan, Arunkumar, Haldeos, Anne, Moreno-Cuesta, Jeronimo, Purohit, Dharam, Vincent, Rachel, Xavier, Kugan, Rohit, Kumar, Alasdair, Frater, Saleem, Malik, David, Carter, Samuel, Jenkins, Lamond, Zoe, Alanna, Wall, Fernandez-Roman, Jaime, Hamilton, David O., Johnson, Emily, Johnston, Brian, Martinez, Maria Lopez, Mulla, Suleman, Shaw, David, Waite, Alicia A.C., Waugh, Victoria, Welters, Ingeborg D., Williams, Karen, Cavazza, Anna, Cockrell, Maeve, Corcoran, Eleanor, Depante, Maria, Finney, Clare, Jerome, Ellen, McPhail, Mark, Nayak, Monalisa, Noble, Harriet, O'Reilly, Kevin, Pappa, Evita, Saha, Rohit, Saha, Sian, Smith, John, Knighton, Abigail, Antcliffe, David, Banach, Dorota, Brett, Stephen, Coghlan, Phoebe, Fernandez, Ziortza, Gordon, Anthony, Rojo, Roceld, Arias, Sonia Sousa, Templeton, Maie, Meredith, Megan, Morris, Lucy, Ryan, Lucy, Clark, Amy, Sampson, Julia, Peters, Cecilia, Dent, Martin, Langley, Margaret, Ashraf, Saima, Wei, Shuying, Andrew, Angela, Bashyal, Archana, Davidson, Neil, Hutton, Paula, McKechnie, Stuart, Wilson, Jean, Baptista, David, Crowe, Rebecca, Fernandes, Rita, Herdman-Grant, Rosaleen, Joseph, Anna, O'Connor, Denise, Allen, Meryem, Loveridge, Adam, McKenley, India, Morino, Eriko, Naranjo, Andres, Simms, Richard, Sollesta, Kathryn, Swain, Andrew, Venkatesh, Harish, Khera, Jacyntha, Fox, Jonathan, Andrew, Gillian, Barclay, Lucy, Callaghan, Marie, Campbell, Rachael, Clark, Sarah, Hope, Dave, Marshall, Lucy, McCulloch, Corrienne, Briton, Kate, Singleton, Jo, Birch, Sohphie, Brimfield, Lutece, Daly, Zoe, Pogson, David, Rose, Steve, Battle, Ceri, Brinkworth, Elaine, Harford, Rachel, Murphy, Carl, Newey, Luke, Rees, Tabitha, Williams, Marie, Arnold, Sophie, Polgarova, Petra, Stroud, Katerina, Meaney, Eoghan, Jones, Megan, Ng, Anthony, Agrawal, Shruti, Pathan, Nazima, White, Deborah, Daubney, Esther, Elston, Kay, Grauslyte, Lina, Hussain, Musarat, Phull, Mandeep, Pogreban, Tatiana, Rosaroso, Lace, Salciute, Erika, Franke, George, Wong, Joanna, George, Aparna, Ortiz-Ruiz de Gordoa, Laura, Peasgood, Emily, Phillips, Claire, Bates, Michelle, Dasgin, Jo, Gill, Jaspret, Nilsson, Annette, Scriven, James, Delgado, Carlos Castro, Dawson, Deborah, Ding, Lijun, Durrant, Georgia, Ezeobu, Obiageri, Farnell-Ward, Sarah, Harrison, Abiola, Kanu, Rebecca, Leaver, Susannah, Maccacari, Elena, Manna, Soumendu, Saluzzio, Romina Pepermans, Queiroz, Joana, Samakomva, Tinashe, Sicat, Christine, Texeira, Joana, Da Gloria, Edna Fernandes, Lisboa, Ana, Rawlins, John, Mathew, Jisha, Kinch, Ashley, Hurt, William James, Shah, Nirav, Clark, Victoria, Thanasi, Maria, Yun, Nikki, Patel, Kamal, Bennett, Sara, Goodwin, Emma, Jackson, Matthew, Kent, Alissa, Tibke, Clare, Woodyatt, Wiesia, Zaki, Ahmed, Abraheem, Azmerelda, Bamford, Peter, Cawley, Kathryn, Dunmore, Charlie, Faulkner, Maria, Girach, Rumanah, Jeffrey, Helen, Jones, Rhianna, London, Emily, Nagra, Imrun, Nasir, Farah, Sainsbury, Hannah, Smedley, Clare, Patel, Tahera, Smith, Matthew, Chukkambotla, Srikanth, Kazi, Aayesha, Hartley, Janice, Dykes, Joseph, Hijazi, Muhammad, Keith, Sarah, Khan, Meherunnisa, Ryan-Smith, Janet, Springle, Philippa, Thomas, Jacqueline, Truman, Nick, Saad, Samuel, Coleman, Dabheoc, Fine, Christopher, Matt, Roseanna, Gay, Bethan, Dalziel, Jack, Ali, Syamlan, Goodchild, Drew, Harling, Rhiannan, Bhatterjee, Ravi, Goddard, Wendy, Davison, Chloe, Duberly, Stephen, Hargreaves, Jeanette, Bolton, Rachel, Davey, Miriam, Golden, David, Seaman, Rebecca, Cherian, Shiney, Cutler, Sean, Heron, Anne Emma, Roynon-Reed, Anna, Szakmany, Tamas, Williams, Gemma, Richards, Owen, Cheema, Yusuf, Brooke, Hollie, Buckley, Sarah, Suarez, Jose Cebrian, Charlesworth, Ruth, Hansson, Karen, Norris, John, Poole, Alice, Rose, Alastair, Sandhu, Rajdeep, Sloan, Brendan, Smithson, Elizabeth, Thirumaran, Muthu, Wagstaff, Veronica, Metcalfe, Alexandra, Brunton, Mark, Caterson, Jess, Coles, Holly, Frise, Matthew, Rai, Sabi Gurung, Jacques, Nicola, Keating, Liza, Tilney, Emma, Bartley, Shauna, Bhuie, Parminder, Gibson, Sian, Lyle, Amanda, McNeela, Fiona, Radhakrishnan, Jayachandran, Hughes, Alistair, Yates, Bryan, Reynolds, Jessica, Campbell, Helen, Thompsom, Maria, Dodds, Steve, Duffy, Stacey, Greer, Sandra, Shuker, Karen, Tridente, Ascanio, Khade, Reena, Sundar, Ashok, Tsinaslanidis, George, Birkinshaw, Isobel, Carter, Joseph, Howard, Kate, Ingham, Joanne, Joy, Rosie, Pearson, Harriet, Roche, Samantha, Scott, Zoe, Bancroft, Hollie, Bellamy, Mary, Carmody, Margaret, Daglish, Jacqueline, Moore, Faye, Rhodes, Joanne, Sangombe, Mirriam, Kadiri, Salma, Croft, Maria, White, Ian, Frost, Victoria, Aquino, Maia, Jha, Rajeev, Krishnamurthy, Vinodh, Lim, Lai, Lim, Li, Combes, Edward, Joefield, Teishel, Monnery, Sonja, Beech, Valerie, Trotman, Sallyanne, Almaden-Boyle, Christine, Austin, Pauline, Cabrelli, Louise, Cole, Stephen, Casey, Matt, Chapman, Susan, Whyte, Clare, Baird, Yolanda, Butler, Aaron, Chadbourn, Indra, Folkes, Linda, Fox, Heather, Gardner, Amy, Gomez, Raquel, Hobden, Gillian, Hodgson, Luke, King, Kirsten, Margarson, Michael, Martindale, Tim, Meadows, Emma, Raynard, Dana, Thirlwall, Yvette, Helm, David, Margalef, Jordi, Criste, Kristine, Cusack, Rebecca, Golder, Kim, Golding, Hannah, Jones, Oliver, Leggett, Samantha, Male, Michelle, Marani, Martyna, Prager, Kirsty, Williams, Toran, Roberts, Belinda, Salmon, Karen, Anderson, Peter, Archer, Katie, Austin, Karen, Davis, Caroline, Durie, Alison, Kelsall, Olivia, Thrush, Jessica, Vigurs, Charlie, Wild, Laura, Wood, Hannah-Louise, Tranter, Helen, Harrison, Alison, Cowley, Nicholas, McAlindon, Michael, Burtenshaw, Andrew, Digby, Stephen, Low, Emma, Morgan, Aled, Cother, Naiara, Rankin, Tobias, Clayton, Sarah, McCurdy, Alex, Ahmed, Cecilia, Baines, Balvinder, Clamp, Sarah, Colley, Julie, Haq, Risna, Hayes, Anne, Hulme, Jonathan, Hussain, Samia, Joseph, Sibet, Kumar, Rita, Maqsood, Zahira, Purewal, Manjit, Benham, Leonie, Bradshaw, Zena, Brown, Joanna, Caswell, Melanie, Cupitt, Jason, Melling, Sarah, Preston, Stephen, Slawson, Nicola, Stoddard, Emma, Warden, Scott, Deacon, Bethan, Lynch, Ceri, Pothecary, Carla, Roche, Lisa, Howe, Gwenllian Sera, Singh, Jayaprakash, Turner, Keri, Ellis, Hannah, Stroud, Natalie, Hunt, Jodie, Dearden, Joy, Dobson, Emma, Drummond, Andy, Mulcahy, Michelle, Munt, Sheila, O'Connor, Grainne, Philbin, Jennifer, Rishton, Chloe, Tully, Redmond, Winnard, Sarah, Cathcart, Susanne, Duffy, Katharine, Puxty, Alex, Puxty, Kathryn, Turner, Lynne, Ireland, Jane, Semple, Gary, Long, Kate, Whiteley, Simon, Wilby, Elizabeth, Ogg, Bethan, Cowton, Amanda, Kay, Andrea, Kent, Melanie, Potts, Kathryn, Wilkinson, Ami, Campbell, Suzanne, Brown, Ellen, Melville, Julie, Naisbitt, Jay, Joseph, Rosane, Lazo, Maria, Walton, Olivia, Neal, Alan, Alexander, Peter, Allen, Schvearn, Bradley-Potts, Joanne, Brantwood, Craig, Egan, Jasmine, Felton, Timothy, Padden, Grace, Ward, Luke, Moss, Stuart, Glasgow, Susannah, Abel, Lynn, Brett, Michael, Digby, Brian, Gemmell, Lisa, Hornsby, James, MacGoey, Patrick, O'Neil, Pauline, Price, Richard, Rodden, Natalie, Rooney, Kevin, Sundaram, Radha, Thomson, Nicola, Hopkins, Bridget, Thrasyvoulou, Laura, Willis, Heather, Clark, Martyn, Coulding, Martina, Jude, Edward, McCormick, Jacqueline, Mercer, Oliver, Potla, Darsh, Rehman, Hafiz, Savill, Heather, Turner, Victoria, Downes, Charlotte, Holding, Kathleen, Riches, Katie, Hilton, Mary, Hayman, Mel, Subramanian, Deepak, Daniel, Priya, Adanini, Oluronke, Bhatia, Nikhil, Msiska, Maines, Collins, Rebecca, Clement, Ian, Patel, Bijal, Gulati, A., Hays, Carole, Webster, K., Hudson, Anne, Webster, Andrea, Stephenson, Elaine, McCormack, Louise, Slater, Victoria, Nixon, Rachel, Hanson, Helen, Fearby, Maggie, Kelly, Sinead, Bridgett, Victoria, Robinson, Philip, Camsooksai, Julie, Humphrey, Charlotte, Jenkins, Sarah, Reschreiter, Henrik, Wadams, Beverley, Death, Yasmin, Bastion, Victoria, Clarke, Daphene, David, Beena, Kent, Harriet, Lorusso, Rachel, Lubimbi, Gamu, Murdoch, Sophie, Penacerrada, Melchizedek, Thomas, Alastair, Valentine, Jennifer, Vochin, Ana, Wulandari, Retno, Djeugam, Brice, Bell, Gillian, English, Katy, Katary, Amro, Wilcox, Louise, Bruce, Michelle, Connolly, Karen, Duncan, Tracy, T-Michael, Helen, Lindergard, Gabriella, Hey, Samuel, Fox, Claire, Alfonso, Jordan, Durrans, Laura Jayne, Guerin, Jacinta, Blackledge, Bethan, Harris, Jade, Hruska, Martin, Eltayeb, Ayaa, Lamb, Thomas, Hodgkiss, Tracey, Cooper, Lisa, Rothwell, Joanne, Allan, Angela, Anderson, Felicity, Kaye, Callum, Liew, Jade, Medhora, Jasmine, Scott, Teresa, Trumper, Erin, Botello, Adriana, Lankester, Liana, Nikitas, Nikitas, Wells, Colin, Stowe, Bethan, Spencer, Kayleigh, Brandwood, Craig, Smith, Lara, Birchall, Katie, Kolakaluri, Laurel, Baines, Deborah, Sukumaran, Anila, Apetri, Elena, Basikolo, Cathrine, Catlow, Laura, Charles, Bethan, Dark, Paul, Doonan, Reece, Harvey, Alice, Horner, Daniel, Knowles, Karen, Lee, Stephanie, Lomas, Diane, Lyons, Chloe, Marsden, Tracy, McLaughlan, Danielle, McMorrow, Liam, Pendlebury, Jessica, Perez, Jane, Poulaka, Maria, Proudfoot, Nicola, Slaughter, Melanie, Slevin, Kathryn, Thomas, Vicky, Walker, Danielle, Michael, Angiy, Collis, Matthew, Cosier, Tracey, Millen, Gemma, Richardson, Neil, Schumacher, Natasha, Weston, Heather, Rand, James, Baxter, Nicola, Henderson, Steven, Kennedy-Hay, Sophie, McParland, Christopher, Rooney, Laura, Sim, Malcolm, McCreath, Gordan, Akeroyd, Louise, Bano, Shereen, Bromley, Matt, Gurr, Lucy, Lawton, Tom, Morgan, James, Sellick, Kirsten, Warren, Deborah, Wilkinson, Brian, McGowan, Janet, Ledgard, Camilla, Stacey, Amelia, Pye, Kate, Bellwood, Ruth, Bentley, Michael, Bewley, Jeremy, Garland, Zoe, Grimmer, Lisa, Gumbrill, Bethany, Johnson, Rebekah, Sweet, Katie, Webster, Denise, Efford, Georgia, Convery, Karen, Fottrell-Gould, Deirdre, Hudig, Lisa, Keshet-Price, Jocelyn, Randell, Georgina, Stammers, Katie, Bokhari, Maria, Linnett, Vanessa, Lucas, Rachael, McCormick, Wendy, Ritzema, Jenny, Sanderson, Amanda, Wild, Helen, Rostron, Anthony, Roy, Alistair, Woods, Lindsey, Cornell, Sarah, Wakinshaw, Fiona, Rogerson, Kimberley, Jarmain, Jordan, Parker, Robert, Reddy, Amie, Turner-Bone, Ian, Wilding, Laura, Harding, Peter, Abernathy, Caroline, Foster, Louise, Gratrix, Andrew, Martinson, Vicky, Parkinson, Priyai, Stones, Elizabeth, Carbral-Ortega, Llucia, Bercades, Georgia, Brealey, David, Hass, Ingrid, MacCallum, Niall, Martir, Gladys, Raith, Eamon, Reyes, Anna, Smyth, Deborah, Zitter, Letizia, Benyon, Sarah, Marriott, Suzie, Park, Linda, Keenan, Samantha, Gordon, Elizabeth, Quinn, Helen, Baines, Kizzy, Cagova, Lenka, Fofano, Adama, Garner, Lucie, Holcombe, Helen, Mepham, Sue, Mitchell, Alice Michael, Mwaura, Lucy, Praman, Krithivasan, Vuylsteke, Alain, Zamikula, Julie, Purewal, Bally, Rivers, Vanessa, Bell, Stephanie, Blakemore, Hayley, Borislavova, Borislava, Faulkner, Beverley, Gendall, Emma, Goff, Elizabeth, Hayes, Kati, Thomas, Matt, Worner, Ruth, Smith, Kerry, Stephens, Deanna, Mew, Louise, Mwaura, Esther, Stewart, Richard, Williams, Felicity, Wren, Lynn, Sutherland, Sara-Beth, Bevan, Emily, Martin, Jane, Trodd, Dawn, Watson, Geoff, Brown, Caroline Wrey, Collins, Amy, Khaliq, Waqas, Gude, Estefania Treus, Akinkugbe, Olugbenga, Bamford, Alasdair, Beech, Emily, Belfield, Holly, Bell, Michael, Davies, Charlene, Jones, Gareth A.L., McHugh, Tara, Meghari, Hamza, O'Neill, Lauran, Peters, Mark J., Ray, Samiran, Tomas, Ana Luisa, Burn, Iona, Hambrook, Geraldine, Manso, Katarina, Penn, Ruth, Shanmugasundaram, Pradeep, Tebbutt, Julie, Thornton, Danielle, Cole, Jade, Davies, Rhys, Duffin, Donna, Hill, Helen, Player, Ben, Thomas, Emma, Williams, Angharad, Griffin, Denise, Muchenje, Nycola, Mupudzi, Mcdonald, Partridge, Richard, Conyngham, Jo-Anna, Thomas, Rachel, Wright, Mary, Corral, Maria Alvarez, Jacob, Reni, Jones, Cathy, Denmade, Craig, Beavis, Sarah, Dale, Katie, Gascoyne, Rachel, Hawes, Joanne, Pritchard, Kelly, Stevenson, Lesley, Whileman, Amanda, Doble, Patricia, Hutter, Joanne, Pawley, Corinne, Shovelton, Charmaine, Vaida, Marius, Butcher, Deborah, O'Sullivan, Susie, Butterworth-Cowin, Nicola, Ahmad, Norfaizan, Barker, Joann, Bauchmuller, Kris, Bird, Sarah, Cawthron, Kay, Harrington, Kate, Jackson, Yvonne, Kibutu, Faith, Lenagh, Becky, Masuko, Shamiso, Mills, Gary H., Raithatha, Ajay, Wiles, Matthew, Willson, Jayne, Newell, Helen, Lye, Alison, Nwafor, Lorenza, Jarman, Claire, Rowland-Jones, Sarah, Foote, David, Cole, Joby, Thompson, Roger, Watson, James, Hesseldon, Lisa, Macharia, Irene, Chetam, Luke, Smith, Jacqui, Ford, Amber, Anderson, Samantha, Birchall, Kathryn, Housley, Kay, Walker, Sara, Milner, Leanne, Hanratty, Helena, Trower, Helen, Phillips, Patrick, Oxspring, Simon, Donne, Ben, Jardine, Catherine, Williams, Dewi, Hay, Alasdair, Flanagan, Rebecca, Hughes, Gareth, Latham, Scott, McKenna, Emma, Anderson, Jennifer, Hull, Robert, Rhead, Kat, Cruz, Carina, Pattison, Natalie, Charnock, Rob, McFarland, Denise, Cosgrove, Denise, Ahmed, Ashar, Morris, Anna, Jakkula, Srinivas, Ali, Asifa, Brady, Megan, Dale, Sam, Dance, Annalisa, Gledhill, Lisa, Greig, Jill, Hanson, Kathryn, Holdroyd, Kelly, Home, Marie, Kelly, Diane, Kitson, Ross, Matapure, Lear, Melia, Deborah, Mellor, Samantha, Nortcliffe, Tonicha, Pinnell, Jez, Robinson, Matthew, Shaw, Lisa, Shaw, Ryan, Thomis, Lesley, Wilson, Alison, Wood, Tracy, Bayo, Lee-Ann, Merwaha, Ekta, Ishaq, Tahira, Hanley, Sarah, Hibbert, Meg, Tetla, Dariusz, Woodford, Chrsitopher, Durga, Latha, Kennard-Holden, Gareth, Branney, Debbie, Frankham, Jordan, Pitts, Sally, White, Nigel, Laha, Shondipon, Verlander, Mark, Williams, Alexandra, Altabaibeh, Abdelhakim, Alvaro, Ana, Gilbert, Kayleigh, Ma, Louise, Mostoles, Loreta, Parmar, Chetan, Simpson, Kathryn, Jetha, Champa, Booker, Lauren, Pratley, Anezka, Adams, Colene, Agasou, Anita, Arden, Tracie, Bowes, Amy, Boyle, Pauline, Beekes, Mandy, Button, Heather, Capps, Nigel, Carnahan, Mandy, Carter, Anne, Childs, Danielle, Donaldson, Denise, Hard, Kelly, Hurford, Fran, Hussain, Yasmin, Javaid, Ayesha, Jones, James, Jose, Sanal, Leigh, Michael, Martin, Terry, Millward, Helen, Motherwell, Nichola, Rikunenko, Rachel, Stickley, Jo, Summers, Julie, Ting, Louise, Tivenan, Helen, Tonks, Louise, Wilcox, Rebecca, Holland, Maureen, Keenan, Natalie, Lyons, Marc, Wassall, Helen, Marsh, Chris, Mahenthran, Mervin, Carter, Emma, Kong, Thomas, Blackman, Helen, Creagh-Brown, Ben, Donlon, Sinead, Michalak-Glinska, Natalia, Mtuwa, Sheila, Pristopan, Veronika, Salberg, Armorel, Smith, Eleanor, Stone, Sarah, Piercy, Charles, Verula, Jerik, Burda, Dorota, Montaser, Rugia, Harden, Lesley, Mayangao, Irving, Marriott, Cheryl, Bradley, Paul, Harris, Celia, Anderson, Susan, Andrews, Eleanor, Birch, Janine, Collins, Emma, Hammerton, Kate, O'Leary, Ryan, Clark, Michele, Purvis, Sarah, Barber, Russell, Hewitt, Claire, Hilldrith, Annette, Jackson-Lawrence, Karen, Shepardson, Sarah, Wills, Maryanne, Butler, Susan, Tavares, Silvia, Cunningham, Amy, Hindale, Julia, Arif, Sarwat, Bean, Sarah, Burt, Karen, Spivey, Michael, Demetriou, Carrie, Eckbad, Charlotte, Hierons, Sarah, Howie, Lucy, Mitchard, Sarah, Ramos, Lidia, Serrano-Ruiz, Alfredo, White, Katie, Kelly, Fiona, Cristiano, Daniele, Dormand, Natalie, Farzad, Zohreh, Gummadi, Mahitha, Liyanage, Kamal, Patel, Brijesh, Salmi, Sara, Sloane, Geraldine, Thwaites, Vicky, Varghese, Mathew, Zborowski, Anelise C., Allan, John, Geary, Tim, Houston, Gordon, Meikle, Alistair, O'Brien, Peter, Forsey, Miranda, Kaliappan, Agilan, Nicholson, Anne, Riches, Joanne, Vertue, Mark, Allan, Elizabeth, Darlington, Kate, Davies, Ffyon, Easton, Jack, Kumar, Sumit, Lean, Richard, Menzies, Daniel, Pugh, Richard, Qiu, Xinyi, Davies, Llinos, Williams, Hannah, Scanlon, Jeremy, Davies, Gwyneth, Mackay, Callum, Lewis, Joannne, Rees, Stephanie, Oblak, Metod, Popescu, Monica, Thankachen, Mini, Higham, Andrew, Simpson, Kerry, Craig, Jayne, Baruah, Rosie, Morris, Sheila, Ferguson, Susie, Shepherd, Amy, Prockter Moore, Luke Stephen, Vizcaychipi, Marcela Paola, Gomes de Almeida Martins, Laura, Carungcong, Jaime, Mohamed Ali, Inthakab Ali, Beaumont, Karen, Blunt, Mark, Coton, Zoe, Curgenven, Hollie, Elsaadany, Mohamed, Fernandes, Kay, Ally, Sameena Mohamed, Rangarajan, Harini, Sarathy, Varun, Selvanayagam, Sivarupan, Vedage, Dave, White, Matthew, Gill, Mandy, Paul, Paul, Ratnam, Valli, Shelton, Sarah, Wynter, Inez, Carmody, Siobhain, Page, Valerie Joan, Beith, Claire Marie, Black, Karen, Clements, Suzanne, Morrison, Alan, Strachan, Dominic, Taylor, Margaret, Clarkson, Michelle, D'Sylva, Stuart, Norman, Kathryn, Auld, Fiona, Donnachie, Joanne, Edmond, Ian, Prentice, Lynn, Runciman, Nikole, Salutous, Dario, Symon, Lesley, Todd, Anne, Turner, Patricia, Short, Abigail, Sweeney, Laura, Murdoch, Euan, Senaratne, Dhaneesha, Hill, Michaela, Kannan, Thogulava, Laura, Wild, Crawley, Rikki, Crew, Abigail, Cunningham, Mishell, Daniels, Allison, Harrison, Laura, Hope, Susan, Inweregbu, Ken, Jones, Sian, Lancaster, Nicola, Matthews, Jamie, Nicholson, Alice, Wray, Gemma, Langton, Helen, Prout, Rachel, Watters, Malcolm, Novis, Catherine, Barron, Anthony, Collins, Ciara, Kaul, Sundeep, Passmore, Heather, Prendergast, Claire, Reed, Anna, Rogers, Paula, Shokkar, Rajvinder, Woodruff, Meriel, Middleton, Hayley, Polgar, Oliver, Nolan, Claire, Mahay, Kanta, Collier, Dawn, Hormis, Anil, Maynard, Victoria, Graham, Cheryl, Walker, Rachel, Knights, Ellen, Price, Alicia, Thomas, Alice, Thorpe, Chris, Behan, Teresa, Burnett, Caroline, Hatton, Jonathan, Heeney, Elaine, Mitra, Atideb, Newton, Maria, Pollard, Rachel, Stead, Rachael, Amin, Vishal, Anastasescu, Elena, Anumakonda, Vikram, Karthik, Komala, Kausar, Rizwana, Reid, Karen, Smith, Jacqueline, Imeson-Wood, Janet, Skinner, Denise, Gaylard, Jane, Mullan, Dee, Newman, Julie, Brown, Alison, Crickmore, Vikki, Debreceni, Gabor, Wilkins, Joy, Nicol, Liz, Reece-Anthony, Rosie, Birt, Mark, Ghosh, Alison, Williams, Emma, Allen, Louise, Beranova, Eva, Crisp, Nikki, Deery, Joanne, Hazelton, Tracy, Knight, Alicia, Price, Carly, Tilbey, Sorrell, Turki, Salah, Turney, Sharon, Cooper, Joshua, Finch, Cheryl, Liderth, Sarah, Quinn, Alison, Waddington, Natalia, Coventry, Tina, Fowler, Susan, MacMahon, Michael, McGregor, Amanda, Cowley, Anne, Highgate, Judith, Gregory, Jane, O'Connell, Susan, Smith, Tim, Barberis, Luigi, Gopal, Shameer, Harris, Nichola, Lake, Victoria, Metherell, Stella, Radford, Elizabeth, Daniel, Amelia, Finn, Joanne, Saha, Rajnish, White, Nikki, Donnison, Phil, Trim, Fiona, Eapen, Beena, Birch, Jenny, Bough, Laura, Goodsell, Josie, Tutton, Rebecca, Williams, Patricia, Williams, Sarah, Winter-Goodwin, Barbara, Nichol, Ailstair, Brickell, Kathy, Smyth, Michelle, Murphy, Lorna, Coetzee, Samantha, Gales, Alistair, Otahal, Igor, Raj, Meena, Sell, Craig, Hilltout, Paula, Evitts, Jayne, Tyler, Amanda, Waldron, Joanne, Beesley, Kate, Board, Sarah, Kubisz-Pudelko, Agnieszka, Lewis, Alison, Perry, Jess, Pippard, Lucy, Wood, Di, Buckley, Clare, Barry, Peter, Flint, Neil, Rekha, Patel, Hales, Dawn, Bunni, Lara, Jennings, Claire, Latif, Monica, Marshall, Rebecca, Subramanian, Gayathri, McGuigan, Peter J., Wasson, Christopher, Finn, Stephanie, Green, Jackie, Collins, Erin, King, Bernadette, Campbell, Andy, Smuts, Sara, Duffield, Joseph, Smith, Oliver, Mallon, Lewis, Claire, Watkins, Botfield, Liam, Butler, Joanna, Dexter, Catherine, Fletcher, Jo, Garg, Atul, Kuravi, Aditya, Ranga, Poonam, Virgilio, Emma, Belagodu, Zakaula, Fuller, Bridget, Gherman, Anca, Olufuwa, Olumide, Paramsothy, Remi, Stuart, Carmel, Oakley, Naomi, Kamundi, Charlotte, Tyl, David, Collins, Katy, Silva, Pedro, Taylor, June, King, Laura, Coates, Charlotte, Crowley, Maria, Wakefield, Phillipa, Beadle, Jane, Johnson, Laura, Sargeant, Janet, Anderson, Madeleine, Brady, Ailbhe, Chan, Rebekah, Little, Jeff, McIvor, Shane, Prady, Helena, Whittle, Helen, Mathew, Bijoy, Attwood, Ben, Parsons, Penny, Ward, Geraldine, Bremmer, Pamela, Joe, West, Tracy, Baird, Jim, Ruddy, Davies, Ellie, Sathe, Sonia, Dennis, Catherine, McGregor, Alastair, Parris, Victoria, Srikaran, Sinduya, Sukha, Anisha, Clarke, Noreen, Whiteside, Jonathan, Mascarenhas, Mairi, Donaldson, Avril, Matheson, Joanna, Barrett, Fiona, O'Hara, Marianne, Okeefe, Laura, Bradley, Clare, Eastgate-Jackson, Christine, Filipe, Helder, Martin, Daniel, Maharajh, Amitaa, Garcia, Sara Mingo, Pakou, Glykeria, De Neef, Mark, Dent, Kathy, Horsley, Elizabeth, Akhtar, Muhmmad Nauman, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Clapham, Melanie, Harper, Rosemary, Poultney, Una, Rice, Polly, Mutch, Rachel, Armstrong, Lisa, Bates, Hayley, Dooks, Emma, Farquhar, Fiona, Hairsine, Brigid, McParland, Chantal, Packham, Sophie, Bi, Rehana, Scholefield, Barney, Ashton, Lydia, George, Linsha, Twiss, Sophie, Wright, David, Chablani, Manish, Kirkby, Amy, Netherton, Kimberley, Davies, Kim, O'Brien, Linda, Omar, Zohra, Perkins, Emma, Lewis, Tracy, Sutherland, Isobel, Burns, Karen, Ben Chandler, Dr, Elliott, Kerry, Mallinson, Janine, Turnbull, Alison, Gondo, Prisca, Hadebe, Bernard, Kayani, Abdul, Masunda, Bridgett, Anderson, Taya, Hawcutt, Dan, O'Malley, Laura, Rad, Laura, Rogers, Naomi, Saunderson, Paula, Allison, Kathryn Sian, Afolabi, Deborah, Whitbread, Jennifer, Jones, Dawn, Dore, Rachael, Halkes, Matthew, Mercer, Pauline, Thornton, Lorraine, Dawson, Joy, Garrioch, Sweyn, Tolson, Melanie, Aldridge, Jonathan, Kapoor, Ritoo, Loader, David, Castle, Karen, Humphreys, Sally, Tampsett, Ruth, Mackintosh, Katherine, Ayers, Amanda, Harrison, Wendy, North, Julie, Allibone, Suzanne, Genetu, Roman, Kasipandian, Vidya, Patel, Amit, Mac, Ainhi, Murphy, Anthony, Mahjoob, Parisa, Nazari, Roonak, Worsley, Lucy, Fagan, Andrew, Bemand, Thomas, Black, Ethel, Dela Rosa, Arnold, Howle, Ryan, Jhanji, Shaman, Baikady, Ravishankar Rao, Tatham, Kate Colette, Thomas, Benjamin, Bell, Dina, Boyle, Rosalind, Douglas, Katie, Glass, Lynn, Lee, Emma, Lennon, Liz, Rattray, Austin, Taylor, Abigail, Hughes, Rachel Anne, Thomas, Helen, Rees, Alun, Duskova, Michaela, Phipps, Janet, Brooks, Suzanne, Edwards, Michelle, Quaid, Sheena, Watson, Ekaterina, Brayne, Adam, Fisher, Emma, Hunt, Jane, Jackson, Peter, Kaye, Duncan, Love, Nicholas, Parkin, Juliet, Tuckey, Victoria, Van Koutrik, Lynne, Carter, Sasha, Andrew, Benedict, Findlay, Louise, Adams, Katie, Service, Jen, Williams, Alison, Cheyne, Claire, Saunderson, Anne, Moultrie, Sam, Odam, Miranda, Hall, Kathryn, Mapfunde, Isheunesu, Willis, Charlotte, Lyon, Alex, Sri-Chandana, Chunda, Scherewode, Joslan, Stephenson, Lorraine, Marsh, Sarah, Hardy, John, Houlden, Henry, Moncur, Eleanor, Tariq, Ambreen, Tucci, Arianna, Hobrok, Maria, Loosley, Ronda, McGuinness, Heather, Tench, Helen, Wolf-Roberts, Rebecca, Irvine, Val, Shelley, Benjamin, Gorman, Claire, Gupta, Abhinav, Timlick, Elizabeth, Brady, Rebecca, Milligan, Barry, Bellini, Arianna, Bryant, Jade, Mayer, Anton, Pickard, Amy, Roe, Nicholas, Sowter, Jason, Howlett, Alex, Fidler, Katy, Tagliavini, Emma, Donnelly, Kevin, Boos, Jannik, van der Made, Caspar I., Ramakrishnan, Gayatri, Coughlan, Eamon, Asselta, Rosanna, Löscher, Britt-Sabina, Valenti, Luca V.C., de Cid, Rafael, Bujanda, Luis, Julià, Antonio, Pairo-Castineira, Erola, May, Sandra, Zametica, Berina, Heggemann, Julia, Albillos, Agustín, Banales, Jesus M., Barretina, Jordi, Blay, Natalia, Bonfanti, Paolo, Buti, Maria, Fernandez, Javier, Marsal, Sara, Prati, Daniele, Ronzoni, Luisa, Sacchi, Nicoletta, Schultze, Joachim L., Riess, Olaf, Franke, Andre, Rawlik, Konrad, Ellinghaus, David, Hoischen, Alexander, Schmidt, Axel, and Ludwig, Kerstin U.
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- 2024
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24. DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2
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Sveinn Bjarnason, Jordan A. P. McIvor, Andreas Prestel, Kinga S. Demény, Jakob T. Bullerjahn, Birthe B. Kragelund, Davide Mercadante, and Pétur O. Heidarsson
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Science - Abstract
Abstract More than 1600 human transcription factors orchestrate the transcriptional machinery to control gene expression and cell fate. Their function is conveyed through intrinsically disordered regions (IDRs) containing activation or repression domains but lacking quantitative structural ensemble models prevents their mechanistic decoding. Here we integrate single-molecule FRET and NMR spectroscopy with molecular simulations showing that DNA binding can lead to complex changes in the IDR ensemble and accessibility. The C-terminal IDR of pioneer factor Sox2 is highly disordered but its conformational dynamics are guided by weak and dynamic charge interactions with the folded DNA binding domain. Both DNA and nucleosome binding induce major rearrangements in the IDR ensemble without affecting DNA binding affinity. Remarkably, interdomain interactions are redistributed in complex with DNA leading to variable exposure of two activation domains critical for transcription. Charged intramolecular interactions allowing for dynamic redistributions may be common in transcription factors and necessary for sensitive tuning of structural ensembles.
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- 2024
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25. Doing research in non-specialist mental health services for children and young people: lessons learnt from a process evaluation of the ICALM (Interpersonal Counselling for Adolescent Low Mood) feasibility randomised controlled trial
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Thando Katangwe-Chigamba, Jamie Murdoch, Paul Wilkinson, Viktoria Cestaro, Carys Seeley, Eirini Charami-Roupa, Tim Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Thomas Rhodes, Lee Shepstone, David A. Turner, and Jon Wilson
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Depression ,Low mood ,Early help ,Process evaluation ,Qualitative ,Medicine (General) ,R5-920 - Abstract
Abstract Background The rising prevalence of adolescent mild depression in the UK and the paucity of evidence-based interventions in non-specialist sectors where most cases present, creates an urgent need for early psychological interventions. Randomised controlled trials (RCTs) are considered the gold standard for obtaining unbiased estimates of intervention effectiveness. However, the complexity of mental health settings poses great challenges for effectiveness evaluations. This paper reports learning from an embedded process evaluation of the ICALM RCT which tested the feasibility of delivering Interpersonal Counselling for Adolescents (IPC-A) plus Treatment as Usual (TAU) versus TAU only for adolescent (age 12–18) mild depression by non-qualified mental health professionals in non-specialist sectors. Methods A qualitative mixed methods process evaluation, drawing on Bronfenbrenner’s socioecological model to investigate key influences on trial delivery across macro-(e.g. policy), meso-(e.g. service characteristics) and micro-(e.g. on-site trial processes) contextual levels. Data collection methods included 9 site questionnaires, 4 observations of team meetings, policy documents, and 18 interviews with stakeholders including therapists, heads of service and managers. Thematic analysis focused on understanding how contextual features shaped trial implementation. Results The ICALM trial concluded in 2022 having only randomised 14 out of the target 60 young people. At a macro-level, trial delivery was impacted by the COVID-19 pandemic, with services reporting a sharp increase in cases of (social) anxiety over low mood, and backlogs at central referral points which prolonged waiting times for mild cases (e.g. low mood). An interaction between high demand and lack of capacity at a meso-service level led to low prioritisation of trial activities at a micro-level. Unfamiliarity with research processes (e.g. randomisation) and variation in TAU support also accentuated the complexities of conducting an RCT in this setting. Conclusions Conducting a RCT of IPC-A in non-specialist services is not feasible in the current context. Failure to conduct effectiveness trials in this setting has clinical implications, potentially resulting in escalation of mild mental health problems. Research done in this setting should adopt pragmatic and innovative recruitment and engagement approaches (e.g. creating new referral pathways) and consider alternative trial designs, e.g. cluster, stepped-wedge or non-controlled studies using complex systems approaches to embrace contextual complexity. Trial registration ISRCTN registry, ISRCTN82180413. Registered on 31 December 2019.
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- 2024
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26. Changing Prevalence of Medication Use in People with Cirrhosis: A Retrospective Cohort Study Using Pharmaceutical Benefits Scheme Data
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Hayward, Kelly L., Weersink, Rianne A., Bernardes, Christina M., McIvor, Carolyn, Rahman, Tony, Skoien, Richard, Clark, Paul J., Stuart, Katherine A., Hartel, Gunter, Valery, Patricia C., and Powell, Elizabeth E.
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- 2023
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27. Photography, war and gender : redefining women's militancy during and after conflict in Ireland and Spain
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McIvor, Jessica Elizabeth, Soo, Gregory, and Lavery, Jane
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Bringing together the comparative case studies of revolutionary Ireland (1916-1923) and the Spanish Civil War (1936-1939), this thesis provides an innovative social history of militant women's photographic practices during conflict and in its aftermath. In particular, this study draws on material and feminist approaches to photography as it focuses on women's roles as producers, editors, and collectors of photography across public and private networks, as it traces the complex lives and afterlives of these photographs as they circulate during and after war. Historicising and rereading militant women's photography uncovers alternative narratives of war that enrich scholarly knowledge of gender and conflict. This research reveals that militant women used photography to articulate their own militant identities, to legitimise and negotiate their participation during war, and to contest their erasure from public narratives of conflict. Despite facing violent repression, militant women's photographic practices subverted the institutional attempts to erase them by building counter-narratives of defiant remembrance. This thesis calls on us to recognise these narratives and bring them to the forefront of our understanding of gender and war in Ireland and Spain. In addition, reconceptualising our approach to militant women's photographic practices enables us to move beyond linear narratives of forgetting and rediscovery, and interrogate the role of photographic visibility within patriarchal narratives of war. Within contemporary cultural discourses, visibility is framed as a means of recovery for women; however, the case studies in this thesis reveal that this renewed visibility is still formed in negotiation with patriarchal frameworks of war. Within this representation of women's militancy, active participation is visualised within a masculinist framework that erases those who do not fit within this limited definition. This thesis argues that the alternative gazes on war seen in militant women's photographic practices hold the potential to disrupt and dismantle patriarchal narratives of war.
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- 2022
28. Pharmacist-led medication management services: a qualitative exploration of transition-of-care cardiovascular disease patient experiences
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Jennifer White, Aaron L Sverdlov, Joshua Bennetts, Hayley Croft, Joyce Cooper, Dawn McIvor, Nicholas Eadie, Marcelle Appay, and Doan Ngo
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Medicine - Abstract
Objective Hospitalisation due to medication-related problems is a major health concern, particularly for those with pre-existing, or those at high risk of developing cardiovascular disease (CVD). Postdischarge medication reviews (PDMRs) may form a core component of reducing hospital readmissions due to medication-related problems. This study aimed to explore postdischarge CVD patients’ perspectives of, and experiences with, pharmacist-led medication management services. A secondary aim explored attitudes towards the availability of PDMRs.Design An interpretative qualitative study involving 16 semistructured interviews. Data were analysed using an inductive thematic approach.Setting Patients with CVD discharged to a community setting from the John Hunter Hospital, an 820-bed tertiary referral hospital based in New South Wales, Australia.Participants Patients with pre-existing or newly diagnosed CVD who were recently discharged from the hospital.Results A total of 16 interviews were conducted to reach thematic saturation. Nine participants (56%) were male. The mean age of participants was 57.5 (±13.2) years. Three emergent themes were identified: (1) poor medication understanding impacts transition from the hospital to home; (2) factors influencing medication concordance following discharge and (3) perceived benefits of routine PDMRs.Conclusions There is a clear need to further improve the quality use of medicines and health literacy of transition-of-care patients with CVD. Our findings indicate that the engagement of transition-of-care patients with CVD with pharmacist-led medication management services is minimal. Pharmacists are suitable to provide essential and tailored medication review services to patients with CVD as part of a multidisciplinary healthcare team. The implementation of routine, pharmacist-led PDMRs may be a feasible means of providing patients with access to health education following their transition from hospital back to community, improving their health literacy and reducing rehospitalisations due to medication-related issues.
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- 2024
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29. Changing Prevalence of Medication Use in People with Cirrhosis: A Retrospective Cohort Study Using Pharmaceutical Benefits Scheme Data
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Kelly L. Hayward, Rianne A. Weersink, Christina M. Bernardes, Carolyn McIvor, Tony Rahman, Richard Skoien, Paul J. Clark, Katherine A. Stuart, Gunter Hartel, Patricia C. Valery, and Elizabeth E. Powell
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Therapeutics. Pharmacology ,RM1-950 ,Pharmacy and materia medica ,RS1-441 - Abstract
Abstract Background Safe and appropriate use of medicines is essential to improve health outcomes in cirrhosis. However, little is known about the number and type of medicines dispensed to people with cirrhosis in Australia, as this predominantly occurs in the community. We aimed to characterise the prescriptions dispensed to people with cirrhosis and explore changes in the use of medication groups over time. Methods Pharmaceutical Benefits Scheme data between 1 January 2016 and 30 June 2020 was extracted for consenting CirCare participants (multi-site, prospective, observational study). Prescriptions dispensed from cirrhosis diagnosis until liver transplant or death were included. Safety classifications for dispensed medicines were defined using published evidence-based recommendations. The pattern of medication use was analysed in 6-monthly time intervals. Generalised estimating equations models were used to estimate the change in consumption of medicines over time. Results Five hundred twenty-two patients (mean age 60 years, 70% male, 34% decompensated at recruitment) were dispensed 89,615 prescriptions during the follow-up period, representing a median of 136 [interquartile range (IQR) 62–237] prescriptions and a median of 16 (IQR 11–23) unique medicines per patient (total n = 9306 medicines). The most commonly used medicines were proton pump inhibitors (PPIs) (dispensed at least once to 73% of patients), opioids (68%) and antibiotics (89%). Polypharmacy was prevalent, with 59–69% of observed participants in each time period dispensed five or more unique medicines. Prescription medication use increased over time (p
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- 2023
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30. Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
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Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., drury, H.J.C., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A.-M., Guio, B. Guillen, Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., Henson, H.H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., s. Kaprowska, Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J.-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., D-C. Man, W., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, G., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newman, J., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O'Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Hanley, K. Piper, Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Reddy, A., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., McCall, J. Weir, Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Brown, C. Wrey, Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., Zheng, Bang, Vivaldi, Giulia, Daines, Luke, Leavy, Olivia C., Richardson, Matthew, Elneima, Omer, McAuley, Hamish J.C., Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M., Harris, Victoria C., Houchen-Wolloff, Linzy, Greening, Neil J., Pfeffer, Paul E., Hurst, John R., Brown, Jeremy S., Shankar-Hari, Manu, Echevarria, Carlos, De Soyza, Anthony, Harrison, Ewen M., Docherty, Annemarie B., Lone, Nazir, Quint, Jennifer K., Chalmers, James D., Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krishna, Raman, Betty, Heaney, Liam G., Wain, Louise V., Evans, Rachael A., Brightling, Christopher E., Martineau, Adrian, and Sheikh, Aziz
- Published
- 2023
- Full Text
- View/download PDF
31. A MEMS gravimeter with multi-axis gravitational sensitivity
- Author
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Middlemiss, Richard P., Campsie, Paul, Cunningham, William, Douglas, Rebecca, McIvor, Victoria, Hough, James, Rowan, Sheila, Paul, Douglas J., Prasad, Abhinav, and Hammond, G. D.
- Subjects
Physics - Applied Physics - Abstract
A single-axis Microelectromechanical system gravimeter has recently been developed at the University of Glasgow. The sensitivity and stability of this device was demonstrated by measuring the Earth tides. The success of this device was enabled in part by its extremely low resonant frequency. This low frequency was achieved with a geometric anti-spring design, fabricated using well-established photolithography and dry etch techniques. Analytical models can be used to calculate the results of these non-linear oscillating systems, but the power of finite element analysis has not been fully utilised to explore the parameter space before now. In this article, the results of previous analytical solutions are replicated using finite element models, before applying the same techniques to optimise the design of the gravimeter. These computer models provide the ability to investigate the effect of the fabrication material of the device: anisotropic <100> crystalline silicon. This is a parameter that is difficult to investigate analytically, but finite element modelling is demonstrated here to provide accurate predictions of real gravimeter behaviour by taking anisotropy into account. The finite element models are then used to demonstrate the design of a three-axis gravimeter enabling the gravity tensor to be measured - a significantly more powerful surveying tool than the original single-axis device.
- Published
- 2021
32. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
- Author
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Abel, K., Adamali, H., Adeloye, D., Adeyemi, O., Adrego, R., Aguilar Jimenez, L.A., Ahmad, S., Ahmad Haider, N., Ahmed, R., Ahwireng, N., Ainsworth, M., Al-Sheklly, B., Alamoudi, A., Ali, M., Aljaroof, M., All, A.M., Allan, L., Allen, R.J., Allerton, L., Allsop, L., Almeida, P., Altmann, D., Alvarez Corral, M., Amoils, S., Anderson, D., Antoniades, C., Arbane, G., Arias, A., Armour, C., Armstrong, L., Armstrong, N., Arnold, D., Arnold, H., Ashish, A., Ashworth, A., Ashworth, M., Aslani, S., Assefa-Kebede, H., Atkin, C., Atkin, P., Aul, R., Aung, H., Austin, L., Avram, C., Ayoub, A., Babores, M., Baggott, R., Bagshaw, J., Baguley, D., Bailey, L., Baillie, J.K., Bain, S., Bakali, M., Bakau, M., Baldry, E., Baldwin, D., Baldwin, M., Ballard, C., Banerjee, A., Bang, B., Barker, R.E., Barman, L., Barratt, S., Barrett, F., Basire, D., Basu, N., Bates, M., Bates, A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Drury, H.J.C., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A.-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., Henson, H.H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, 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- 2023
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33. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
- Author
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Baillie, J. Kenneth, Openshaw, Peter J.M., Semple, Malcolm G., Alex, Beatrice, Andrikopoulos, Petros, Bach, Benjamin, Barclay, Wendy S., Bogaert, Debby, Chand, Meera, Chechi, Kanta, Cooke, Graham S., da Silva Filipe, Ana, de Silva, Thushan, Docherty, Annemarie B., dos Santos Correia, Gonçalo, Dumas, Marc-Emmanuel, Dunning, Jake, Fletcher, Tom, Green, Christopher A., Greenhalf, William, Griffin, Julian, Gupta, Rishi K., Harrison, Ewen M., Ho, Antonia Y.W., Holden, Karl, Horby, Peter W., Ijaz, Samreen, Khoo, Say, Klenerman, Paul, Law, Andrew, Lewis, Matthew, Liggi, Sonia, Lim, Wei Shen, Maslen, Lynn, Mentzer, Alexander J., Merson, Laura, Meynert, Alison M, Moore, Shona C., Noursadeghi, Mahdad, Olanipekun, Michael, Osagie, Anthonia, Palmarini, Massimo, Palmieri, Carlo, Paxton, William A., Pollakis, Georgios, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Russell, Clark D., Sancho-Shimizu, Vanessa, Sands, Caroline, Scott, Janet T., Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Summers, Charlotte, Swann, Olivia V., Takats, Zoltan, Takis, Panteleimon, Tedder, Richard S., Thompson, A.A. Roger, Thomson, Emma C., Thwaites, Ryan S., Turtle, Lance C.W., Zambon, Maria, Drake, Thomas M., Fairfield, Cameron J., Knight, Stephen R., Mclean, Kenneth A., Murphy, Derek, Norman, Lisa, Pius, Riinu, Shaw, Catherine A., Connor, Marie, Dalton, Jo, Gamble, Carrol, Girvan, Michelle, Halpin, Sophie, Harrison, Janet, Jackson, Clare, Lee, James, Marsh, Laura, Plotkin, Daniel, Roberts, Stephanie, Saviciute, Egle, Clohisey, Sara, Hendry, Ross, Knight, Susan, Lahnsteiner, Eva, Leeming, Gary, Norris, Lucy, Scott-Brown, James, Tait, Sarah, Wham, Murray, Clark, Richard, Coutts, Audrey, Donelly, Lorna, Fawkes, Angie, Gilchrist, Tammy, Hafezi, Katarzyna, MacGillivray, Louise, Maclean, Alan, McCafferty, Sarah, Morrice, Kirstie, Murphy, Lee, Wrobel, Nicola, Carson, Gail, Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L., Alegria, Ana, Allen, Sam, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nicholas, Bassford, 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Joyce, Murphy, Ellen G, Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. 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A., Batterham, R., Baxendale, H., Bayes, H., Beadsworth, M., Beckett, P., Beggs, M., Begum, M., Beirne, P., Bell, D., Bell, R., Bennett, K., Beranova, E., Bermperi, A., Berridge, A., Berry, C., Betts, S., Bevan, E., Bhui, K., Bingham, M., Birchall, K., Bishop, L., Bisnauthsing, K., Blaikely, J., Bloss, A., Bolger, A., Bolton, C.E., Bonnington, J., Botkai, A., Bourne, C., Bourne, M., Bramham, K., Brear, L., Breen, G., Breeze, J., Briggs, A., Bright, E., Brightling, C.E., Brill, S., Brindle, K., Broad, L., Broadley, A., Brookes, C., Broome, M., Brown, A., Brown, J., Brown, J.S., Brown, M., Brown, V., Brugha, T., Brunskill, N., Buch, M., Buckley, P., Bularga, A., Bullmore, E., Burden, L., Burdett, T., Burn, D., Burns, G., Burns, A., Busby, J., Butcher, R., Butt, A., Byrne, S., Cairns, P., Calder, P.C., Calvelo, E., Carborn, H., Card, B., Carr, C., Carr, L., Carson, G., Carter, P., Casey, A., Cassar, M., Cavanagh, J., Chablani, M., Chalder, T., Chalmers, J.D., Chambers, R.C., Chan, F., Channon, K.M., Chapman, K., Charalambou, A., Chaudhuri, N., Checkley, A., Chen, J., Cheng, Y., Chetham, L., Childs, C., Chilvers, E.R., Chinoy, H., Chiribiri, A., Chong-James, K., Choudhury, G., Choudhury, N., Chowienczyk, P., Christie, C., Chrystal, M., Clark, D., Clark, C., Clarke, J., Clohisey, S., Coakley, G., Coburn, Z., Coetzee, S., Cole, J., Coleman, C., Conneh, F., Connell, D., Connolly, B., Connor, L., Cook, A., Cooper, B., Cooper, J., Cooper, S., Copeland, D., Cosier, T., Coulding, M., Coupland, C., Cox, E., Craig, T., Crisp, P., Cristiano, D., Crooks, M.G., Cross, A., Cruz, I., Cullinan, P., Cuthbertson, D., Daines, L., Dalton, M., Daly, P., Daniels, A., Dark, P., Dasgin, J., David, A., David, C., Davies, E., Davies, F., Davies, G., Davies, G.A., Davies, K., Davies, M.J., Dawson, J., Daynes, E., De Soyza, A., Deakin, B., Deans, A., Deas, C., Deery, J., Defres, S., Dell, A., Dempsey, K., Denneny, E., Dennis, J., Dewar, A., Dharmagunawardena, R., Diar-Bakerly, N., Dickens, C., Dipper, A., Diver, S., Diwanji, S.N., Dixon, M., Djukanovic, R., Dobson, H., Dobson, S.L., Docherty, A.B., Donaldson, A., Dong, T., Dormand, N., Dougherty, A., Dowling, R., Drain, S., Draxlbauer, K., Drury, K., Dulawan, P., Dunleavy, A., Dunn, S., Dupont, C., Earley, J., Easom, N., Echevarria, C., Edwards, S., Edwardson, C., El-Taweel, H., Elliott, A., Elliott, K., Ellis, Y., Elmer, A., Elneima, O., Evans, D., Evans, H., Evans, J., Evans, R., Evans, R.A., Evans, R.I., Evans, T., Evenden, C., Evison, L., Fabbri, L., Fairbairn, S., Fairman, A., Fallon, K., Faluyi, D., Favager, C., Fayzan, T., Featherstone, J., Felton, T., Finch, J., Finney, S., Finnigan, J., Finnigan, L., Fisher, H., Fletcher, S., Flockton, R., Flynn, M., Foot, H., Foote, D., Ford, A., Forton, D., Fraile, E., Francis, C., Francis, R., Francis, S., Frankel, A., Fraser, E., Free, R., French, N., Fu, X., Fuld, J., Furniss, J., Garner, L., Gautam, N., Geddes, J.R., George, J., George, P., Gibbons, M., Gill, M., Gilmour, L., Gleeson, F., Glossop, J., Glover, S., Goodman, N., Goodwin, C., Gooptu, B., Gordon, H., Gorsuch, T., Greatorex, M., Greenhaff, P.L., Greenhalf, W., Greenhalgh, A., Greening, N.J., Greenwood, J., Gregory, H., Gregory, R., Grieve, D., Griffin, D., Griffiths, L., Guerdette, A-M., Guillen Guio, B., Gummadi, M., Gupta, A., Gurram, S., Guthrie, E., Guy, Z., H Henson, H., Hadley, K., Haggar, A., Hainey, K., Hairsine, B., Haldar, P., Hall, I., Hall, L., Halling-Brown, M., Hamil, R., Hancock, A., Hancock, K., Hanley, N.A., Haq, S., Hardwick, H.E., Hardy, E., Hardy, T., Hargadon, B., Harrington, K., Harris, E., Harris, V.C., Harrison, E.M., Harrison, P., Hart, N., Harvey, A., Harvey, M., Harvie, M., Haslam, L., Havinden-Williams, M., Hawkes, J., Hawkings, N., Haworth, J., Hayday, A., Haynes, M., Hazeldine, J., Hazelton, T., Heaney, L.G., Heeley, C., Heeney, J.L., Heightman, M., Heller, S., Henderson, M., Hesselden, L., Hewitt, M., Highett, V., Hillman, T., Hiwot, T., Ho, L.P., Hoare, A., Hoare, M., Hockridge, J., Hogarth, P., Holbourn, A., Holden, S., Holdsworth, L., Holgate, D., Holland, M., Holloway, L., Holmes, K., Holmes, M., Holroyd-Hind, B., Holt, L., Hormis, A., Horsley, A., Hosseini, A., Hotopf, M., Houchen-Wolloff, L., Howard, K., Howard, L.S., Howell, A., Hufton, E., Hughes, A.D., Hughes, J., Hughes, R., Humphries, A., Huneke, N., Hurditch, E., Hurst, J., Husain, M., Hussell, T., Hutchinson, J., Ibrahim, W., Ilyas, F., Ingham, J., Ingram, L., Ionita, D., Isaacs, K., Ismail, K., Jackson, T., Jacob, J., James, W.Y., Jang, W., Jarman, C., Jarrold, I., Jarvis, H., Jastrub, R., Jayaraman, B., Jenkins, R.G., Jezzard, P., Jiwa, K., Johnson, C., Johnson, S., Johnston, D., Jolley, C.J., Jones, D., Jones, G., Jones, H., Jones, I., Jones, L., Jones, M.G., Jones, S., Jose, S., Kabir, T., Kaltsakas, G., Kamwa, V., Kanellakis, N., Kaprowska, s., Kausar, Z., Keenan, N., Kelly, S., Kemp, G., Kerr, S., Kerslake, H., Key, A.L., Khan, F., Khunti, K., Kilroy, S., King, B., King, C., Kingham, L., Kirk, J., Kitterick, P., Klenerman, P., Knibbs, L., Knight, S., Knighton, A., Kon, O., Kon, S., Kon, S.S., Koprowska, S., Korszun, A., Koychev, I., Kurasz, C., Kurupati, P., Laing, C., Lamlum, H., Landers, G., Langenberg, C., Lasserson, D., Lavelle-Langham, L., Lawrie, A., Lawson, C., Layton, A., Lea, A., Leavy, O.C., Lee, D., Lee, J-H., Lee, E., Leitch, K., Lenagh, R., Lewis, D., Lewis, J., Lewis, K.E., Lewis, V., Lewis-Burke, N., Li, X., Light, T., Lightstone, L., Lilaonitkul, W., Lim, L., Linford, S., Lingford-Hughes, A., Lipman, M., Liyanage, K., Lloyd, A., Logan, S., Lomas, D., Lone, N.I., Loosley, R., Lord, J.M., Lota, H., Lovegrove, W., Lucey, A., Lukaschuk, E., Lye, A., Lynch, C., MacDonald, S., MacGowan, G., Macharia, I., Mackie, J., Macliver, L., Madathil, S., Madzamba, G., Magee, N., Magtoto, M.M., Mairs, N., Majeed, N., Major, E., Malein, F., Malim, M., Mallison, G., Man, W.D.-C., Mandal, S., Mangion, K., Manisty, C., Manley, R., March, K., Marciniak, S., Marino, P., Mariveles, M., Marks, M., Marouzet, E., Marsh, S., Marshall, B., Marshall, M., Martin, J., Martineau, A., Martinez, L.M., Maskell, N., Matila, D., Matimba-Mupaya, W., Matthews, L., Mbuyisa, A., McAdoo, S., McAllister-Williams, H., McArdle, A., McArdle, P., McAulay, D., McCann, G.P., drury, H.J.C., McCormick, J., McCormick, W., McCourt, P., McGarvey, L., McGee, C., Mcgee, K., McGinness, J., McGlynn, K., McGovern, A., McGuinness, H., McInnes, I.B., McIntosh, J., McIvor, E., McIvor, K., McLeavey, L., McMahon, A., McMahon, M.J., McMorrow, L., Mcnally, T., McNarry, M., McNeill, J., McQueen, A., McShane, H., Mears, C., Megson, C., Megson, S., Mehta, P., Meiring, J., Melling, L., Mencias, M., Menzies, D., Merida Morillas, M., Michael, A., Miller, C., Milligan, L., Mills, C., Mills, N.L., Milner, L., Misra, S., Mitchell, J., Mohamed, A., Mohamed, N., Mohammed, S., Molyneaux, P.L., Monteiro, W., Moriera, S., Morley, A., Morrison, L., Morriss, R., Morrow, A., Moss, A.J., Moss, P., Motohashi, K., Msimanga, N., Mukaetova-Ladinska, E., Munawar, U., Murira, J., Nanda, U., Nassa, H., Nasseri, M., Neal, A., Needham, R., Neill, P., Neubauer, S., Newby, D.E., Newell, H., Newman, T., Newton-Cox, A., Nicholson, T., Nicoll, D., Nikolaidis, A., Nolan, C.M., Noonan, M.J., Norman, C., Novotny, P., Nunag, J., Nwafor, L., Nwanguma, U., Nyaboko, J., O'Brien, C., O'Donnell, K., O'Regan, D., O'Brien, L., Odell, N., Ogg, G., Olaosebikan, O., Oliver, C., Omar, Z., Openshaw, P.J.M., Orriss-Dib, L., Osborne, L., Osbourne, R., Ostermann, M., Overton, C., Owen, J., Oxton, J., Pack, J., Pacpaco, E., Paddick, S., Painter, S., Pakzad, A., Palmer, S., Papineni, P., Paques, K., Paradowski, K., Pareek, M., Parekh, D., Parfrey, H., Pariante, C., Parker, S., Parkes, M., Parmar, J., Patale, S., Patel, B., Patel, M., Patel, S., Pattenadk, D., Pavlides, M., Payne, S., Pearce, L., Pearl, J.E., Peckham, D., Pendlebury, J., Peng, Y., Pennington, C., Peralta, I., Perkins, E., Peterkin, Z., Peto, T., Petousi, N., Petrie, J., Pfeffer, P., Phipps, J., Pimm, J., Piper Hanley, K., Pius, R., Plant, H., Plein, S., Plekhanova, T., Plowright, M., Poinasamy, K., Polgar, O., Poll, L., Porter, J.C., Porter, J., Portukhay, S., Powell, N., Prabhu, A., Pratt, J., Price, A., Price, C., Price, D., Price, L., Prickett, A., Propescu, J., Prosper, S., Pugmire, S., Quaid, S., Quigley, J., Quint, J., Qureshi, H., Qureshi, I.N., Radhakrishnan, K., Rahman, N.M., Ralser, M., Raman, B., Ramos, A., Ramos, H., Rangeley, J., Rangelov, B., Ratcliffe, L., Ravencroft, P., Reddington, A., Reddy, R., Redfearn, H., Redwood, D., Reed, A., Rees, M., Rees, T., Regan, K., Reynolds, W., Ribeiro, C., Richards, A., Richardson, E., Richardson, M., Rivera-Ortega, P., Roberts, K., Robertson, E., Robinson, E., Robinson, L., Roche, L., Roddis, C., Rodger, J., Ross, A., Ross, G., Rossdale, J., Rostron, A., Rowe, A., Rowland, A., Rowland, J., Rowland, M.J., Rowland-Jones, S.L., Roy, K., Roy, M., Rudan, I., Russell, R., Russell, E., Saalmink, G., Sabit, R., Sage, E.K., Samakomva, T., Samani, N., Sampson, C., Samuel, K., Samuel, R., Sanderson, A., Sapey, E., Saralaya, D., Sargant, J., Sarginson, C., Sass, T., Sattar, N., Saunders, K., Saunders, R.M., Saunders, P., Saunders, L.C., Savill, H., Saxon, W., Sayer, A., Schronce, J., Schwaeble, W., Scott, J.T., Scott, K., Selby, N., Semple, M.G., Sereno, M., Sewell, T.A., Shah, A., Shah, K., Shah, P., Shankar-Hari, M., Sharma, M., Sharpe, C., Sharpe, M., Shashaa, S., Shaw, A., Shaw, K., Shaw, V., Sheikh, A., Shelton, S., Shenton, L., Shevket, K., Shikotra, A., Short, J., Siddique, S., Siddiqui, S., Sidebottom, J., Sigfrid, L., Simons, G., Simpson, J., Simpson, N., Singapuri, A., Singh, C., Singh, S., Singh, S.J., Sissons, D., Skeemer, J., Slack, K., Smith, A., Smith, D., Smith, S., Smith, J., Smith, L., Soares, M., Solano, T.S., Solly, R., Solstice, A.R., Soulsby, T., Southern, D., Sowter, D., Spears, M., Spencer, L.G., Speranza, F., Stadon, L., Stanel, S., Steele, N., Steiner, M., Stensel, D., Stephens, G., Stephenson, L., Stern, M., Stewart, I., Stimpson, R., Stockdale, S., Stockley, J., Stoker, W., Stone, R., Storrar, W., Storrie, A., Storton, K., Stringer, E., Strong-Sheldrake, S., Stroud, N., Subbe, C., Sudlow, C.L., Suleiman, Z., Summers, C., Summersgill, C., Sutherland, D., Sykes, D.L., Sykes, R., Talbot, N., Tan, A.L., Tarusan, L., Tavoukjian, V., Taylor, A., Taylor, C., Taylor, J., Te, A., Tedd, H., Tee, C.J., Teixeira, J., Tench, H., Terry, S., Thackray-Nocera, S., Thaivalappil, F., Thamu, B., Thickett, D., Thomas, C., Thomas, D.C., Thomas, S., Thomas, A.K., Thomas-Woods, T., Thompson, T., Thompson, A.A.R., Thornton, T., Thorpe, M., Thwaites, R.S., Tilley, J., Tinker, N., Tiongson, G.F., Tobin, M., Tomlinson, J., Tong, C., Toshner, M., Touyz, R., Tripp, K.A., Tunnicliffe, E., Turnbull, A., Turner, E., Turner, S., Turner, V., Turner, K., Turney, S., Turtle, L., Turton, H., Ugoji, J., Ugwuoke, R., Upthegrove, R., Valabhji, J., Ventura, M., Vere, J., Vickers, C., Vinson, B., Wade, E., Wade, P., Wain, L.V., Wainwright, T., Wajero, L.O., Walder, S., Walker, S., Wall, E., Wallis, T., Walmsley, S., Walsh, J.A., Walsh, S., Warburton, L., Ward, T.J.C., Warwick, K., Wassall, H., Waterson, S., Watson, E., Watson, L., Watson, J., Weir McCall, J., Welch, C., Welch, H., Welsh, B., Wessely, S., West, S., Weston, H., Wheeler, H., White, S., Whitehead, V., Whitney, J., Whittaker, S., Whittam, B., Whitworth, V., Wight, A., Wild, J., Wilkins, M., Wilkinson, D., Williams, B., Williams, N., Williams, J., Williams-Howard, S.A., Willicombe, M., Willis, G., Willoughby, J., Wilson, A., Wilson, D., Wilson, I., Window, N., Witham, M., Wolf-Roberts, R., Wood, C., Woodhead, F., Woods, J., Wootton, D.G., Wormleighton, J., Worsley, J., Wraith, D., Wrey Brown, C., Wright, C., Wright, L., Wright, S., Wyles, J., Wynter, I., Xu, M., Yasmin, N., Yasmin, S., Yates, T., Yip, K.P., Young, B., Young, S., Young, A., Yousuf, A.J., Zawia, A., Zeidan, L., Zhao, B., Zheng, B., Zongo, O., Liew, Felicity, Talwar, Shubha, Cross, Andy, Willett, Brian J., Scott, Sam, Logan, Nicola, Siggins, Matthew K., Swieboda, Dawid, Sidhu, Jasmin K., Efstathiou, Claudia, Davis, Chris, Mohamed, Noura, Nunag, Jose, King, Clara, Rowland-Jones, Sarah L., Chalmers, James D., Ho, Ling-Pei, Horsley, Alexander, Raman, Betty, Poinasamy, Krisnah, Marks, Michael, Kon, Onn Min, Howard, Luke, Wootton, Daniel G., Dunachie, Susanna, Quint, Jennifer K., Evans, Rachael A., Wain, Louise V., Fontanella, Sara, de Silva, Thushan I., Ho, Antonia, Harrison, Ewen, Brightling, Christopher, and Turtle, Lance
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- 2023
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34. Language-in-Education Policies and Indigenous Language Revitalization Efforts in Canada: Considerations for Non-Dominant Language Education in the Global South
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McIvor, Onowa and Ball, Jessica
- Abstract
Indigenous languages are struggling for breath in the Global North. In Canada, Indigenous language medium schools and early childhood programs remain independent and marginalized. Despite government commitments, there is little support for Indigenous language-in-education policy and initiatives. This article describes an inaugural, countrywide, federally-funded, Indigenous-led language revitalization research project, entitled NE?OL?EW__("one mind-one people"). The project brings together nine Indigenous partners to build a country-wide network and momentum to pressure multi-levels of government to honour agreements enshrining the right of children to learn their Indigenous language. The project is documenting approaches to create new Indigenous language speakers, focusing on adult language learners able to keep the language vibrant and teach their language to children. The article reflects upon how this Northern emphasis on Indigenous language revitalization and country-wide networking initiative is relevant to mother tongue-based education and policy examples in the Global South. The article underscores the need for both community level initiatives (top-down) and government level policy and funding (bottom up) to support child and adult Indigenous language learning.
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- 2019
35. Comparative dose effectiveness of intravenous and intrathecal AAV9.CB7.hIDS, RGX-121, in mucopolysaccharidosis type II mice
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Smith, Miles C., Belur, Lalitha R., Karlen, Andrea D., Erlanson, Olivia, Furcich, Justin, Lund, Troy C., Seelig, Davis, Kitto, Kelley F., Fairbanks, Carolyn A., Kim, Kwi Hye, Buss, Nick, and McIvor, R. Scott
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- 2024
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36. Wild jackdaws can selectively adjust their social associations while preserving valuable long-term relationships
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Michael Kings, Josh J. Arbon, Guillam E. McIvor, Martin Whitaker, Andrew N. Radford, Jürgen Lerner, and Alex Thornton
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Science - Abstract
Abstract Influential theories of the evolution of cognition and cooperation posit that tracking information about others allows individuals to adjust their social associations strategically, re-shaping social networks to favour connections between compatible partners. Crucially, to our knowledge, this has yet to be tested experimentally in natural populations, where the need to maintain long-term, fitness-enhancing relationships may limit social plasticity. Using a social-network-manipulation experiment, we show that wild jackdaws (Corvus monedula) learned to favour social associations with compatible group members (individuals that provided greater returns from social foraging interactions), but resultant change in network structure was constrained by the preservation of valuable pre-existing relationships. Our findings provide insights into the cognitive basis of social plasticity and the interplay between individual decision-making and social-network structure.
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- 2023
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37. Ultimate drivers of forced extra-pair copulations in birds lacking a penis: jackdaws as a case-study
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Rebecca Hooper, Kathryn Maher, Karen Moore, Guillam McIvor, David Hosken, and Alex Thornton
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forced ,extra-pair ,copulations ,FEPC ,jackdaw ,Science - Abstract
Forced copulation is common, presumably because it can increase male reproductive success. Forced extra-pair copulation (FEPC) occurs in birds, even though most species lack a penis and are widely thought to require female cooperation for fertilization. How FEPC persists, despite a presumed lack of siring success and likely non-negligible costs to the male, is unknown. Using the jackdaw (Corvus monedula) as a case study, we use SNPs to quantify the extra-pair paternity rate through FEPC and evaluate explanations for the persistence of FEPC in species without a penis. We then collate evidence for FEPC across penis-lacking birds. Combining genetic and behavioural analyses, our study suggests that the most likely explanations for the maintenance of FEPC in jackdaws are that it provides a selective advantage to males or it is a relic. Our literature review shows that across birds lacking a penis, FEPC is taxonomically widespread, and yet, little is known about its evolution. A broader implementation of the approach used here, combining both genetic and behavioural data, may shed light on why this widespread sexual behaviour persists. Additional work is necessary to understand whether a penis is needed for paternity through forced copulation and to quantify the costs of FEPC.
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- 2024
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38. Comparative dose effectiveness of intravenous and intrathecal AAV9.CB7.hIDS, RGX-121, in mucopolysaccharidosis type II mice
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Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Olivia Erlanson, Justin Furcich, Troy C. Lund, Davis Seelig, Kelley F. Kitto, Carolyn A. Fairbanks, Kwi Hye Kim, Nick Buss, and R. Scott McIvor
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mucopolysaccharidosis type II ,MPS II ,Hunter syndrome ,gene therapy ,adeno-associated virus ,dose-ranging study ,Genetics ,QH426-470 ,Cytology ,QH573-671 - Abstract
Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disease caused by iduronate-2-sulfatase (IDS) deficiency, leading to accumulation of glycosaminoglycans (GAGs) and the emergence of progressive disease. Enzyme replacement therapy is the only currently approved treatment, but it leaves neurological disease unaddressed. Cerebrospinal fluid (CSF)-directed administration of AAV9.CB7.hIDS (RGX-121) is an alternative treatment strategy, but it is unknown if this approach will affect both neurologic and systemic manifestations. We compared the effectiveness of intrathecal (i.t.) and intravenous (i.v.) routes of administration (ROAs) at a range of vector doses in a mouse model of MPS II. While lower doses were completely ineffective, a total dose of 1 × 109 gc resulted in appreciable IDS activity levels in plasma but not tissues. Total doses of 1 × 1010 and 1 × 1011 gc by either ROA resulted in supraphysiological plasma IDS activity, substantial IDS activity levels and GAG reduction in nearly all tissues, and normalized zygomatic arch diameter. In the brain, a dose of 1 × 1011 gc i.t. achieved the highest IDS activity levels and the greatest reduction in GAG content, and it prevented neurocognitive deficiency. We conclude that a dose of 1 × 1010 gc normalized metabolic and skeletal outcomes, while neurologic improvement required a dose of 1 × 1011 gc, thereby suggesting the prospect of a similar direct benefit in humans.
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- 2024
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39. Children's behavioural and emotional wellbeing during the COVID-19 pandemic: Findings from the Born in Bradford COVID-19 mixed methods longitudinal study [version 1; peer review: 1 approved, 2 approved with reservations]
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Rosemary R. C. McEachan, Kate E. Pickett, Kirsty Crossley, Ellena Badrick, Rachael H. Moss, Josie Dickerson, Zahrah Tanveer, Claire McIvor, and Charlotte Endacott
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COVID-19 ,mental health ,children ,poverty ,health inequalities ,ethnicity ,eng ,Medicine ,Science - Abstract
Background The COVID-19 pandemic led to a multitude of immediate social restrictions for many across the world. In the UK, the lives of children and young people were quickly impacted when COVID-19 restrictions led to school closures for most children and restrictions on social interactions. The Born in Bradford COVID-19 longitudinal research study explored the impact of the COVID-19 pandemic on the lives of children and their families living in Bradford. Methods Surveys were administered during the first wave of the pandemic (March to June 2020) and compared to findings from before the pandemic. The current study examined the social and emotional wellbeing of children from before to during the pandemic, measured using the parent completed Strengths and Difficulties questionnaire (SDQ). Regression analyses looked at associations between a range of social determinants of health and changes in SDQ scores. Results The results showed that those children most likely to experience difficulties during the pandemic were boys, younger children, those from White British ethnicity (compared to Pakistani heritage children) and those living in the most deprived areas. There were associations between experiencing difficulties and: food insecurity; financial worry; getting below recommended levels of physical activity; and having less than the recommended amount of sleep. Conclusions The effect of COVID-19 restrictions are likely to have had negative consequences on children that could, in time, have long-lasting impacts on the health, wellbeing and development of children in the UK.
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- 2024
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40. Low diversity and abundance of predatory fishes in a peripheral coral reef ecosystem
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Collin T. Williams, Francesco Garzon, Jesse E. M. Cochran, Lyndsey K. Tanabe, Lucy A. Hawkes, Ashlie J. McIvor, Ameer A. Eweida, Paul A. Marshall, and Michael L. Berumen
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biogeography ,fisheries ,Gulf of Aqaba ,marginal seas ,Red Sea ,sharks ,Ecology ,QH540-549.5 - Abstract
Abstract Semi‐enclosed seas are often associated with elevated local threats and distinct biogeographic patterns among marine fishes, but our understanding of how fish assemblage dynamics vary in relation to relatively small semi‐enclosed seas (e.g., the Gulf of Aqaba) remains limited. Baited remote underwater video surveys (n = 111) were conducted across ~300 km of coral reef habitats in the Gulf of Aqaba and the northern Red Sea. A total of 55 predatory fish species were detected, with less than half of all species (n = 23) observed in both basins. Relative abundance patterns between the Gulf of Aqaba and the northern Red Sea were variable among taxa, but nearly twice as many predatory fish were observed per unit of effort in the northern Red Sea. In general, assemblages in both basins were dominated by three taxa (Epinephelinae, Carangidae, and Lethrinidae). Large‐bodied and threatened species were recorded at very low abundances. Multivariate analysis revealed distinct assemblage structuring of coral reef predators between the Gulf of Aqaba and the northern Red Sea. Most of the species driving these differences were recorded in both basins, but occurred at varying levels of abundance. Environmental factors were largely unsuccessful in explaining variation in assemblage structuring. These findings indicate that biological assemblages in the Gulf of Aqaba are more distinct than previously reported and that reef fish assemblage structuring can occur even within a relatively small semi‐enclosed sea. Despite inter‐basin assemblage structuring, the overall low abundance of vulnerable fish species is suggestive of overexploitation in both the Gulf of Aqaba and the northern Red Sea of Saudi Arabia. As the region surveyed is currently undergoing large‐scale coastal development, the results presented herein aim to guide spatial management and recovery plans for these coral reef systems in relation to this development.
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- 2024
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41. Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance
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Caroline C. Churchill, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, and Carolyn A. Fairbanks
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AAV5 ,agmatine ,human arginine decarboxylase ,intrathecal ,opioid tolerance ,AAV9 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration. Endogenous agmatine has been previously detected in the central nervous system. The presence of a biochemical pathway for agmatine synthesis offers the opportunity for site-specific overexpression of the presumptive synthetic enzyme for local therapeutic effects. In the present study, we evaluated the development of opioid analgesic tolerance in ICR-CD1 mice pre-treated with either vehicle control or intrathecally delivered adeno-associated viral vectors (AAV) carrying the gene for human arginine decarboxylase (hADC). Vehicle-treated or AAV-hADC-treated mice were each further divided into two groups which received repeated delivery over three days of either saline or systemically-delivered morphine intended to induce opioid analgesic tolerance. Morphine analgesic dose-response curves were constructed in all subjects on day four using the warm water tail flick assay as the dependent measure. We observed that pre-treatment with AAV-hADC prevented the development of analgesic tolerance to morphine. Peripheral and central nervous system tissues were collected and analyzed for presence of hADC mRNA. In a similar experiment, AAV-hADC pre-treatment prevented the development of analgesic tolerance to a high dose of the opioid neuropeptide endomorphin-2. Intrathecal delivery of anti-agmatine IgG (but not normal IgG) reversed the inhibition of endomorphin-2 analgesic tolerance in AAV-hADC-treated mice. To summarize, we report here the effects of AAV-mediated gene transfer of human ADC (hADC) in models of opioid-induced analgesic tolerance. This study suggests that gene therapy may contribute to reducing opioid analgesic tolerance.
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- 2024
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42. Wild jackdaws can selectively adjust their social associations while preserving valuable long-term relationships
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Kings, Michael, Arbon, Josh J., McIvor, Guillam E., Whitaker, Martin, Radford, Andrew N., Lerner, Jürgen, and Thornton, Alex
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- 2023
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43. Clinical Strains of Mycobacterium tuberculosis Representing Different Genotype Families Exhibit Distinct Propensities to Adopt the Differentially Culturable State
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Bhavna Gowan Gordhan, Kiyasha Padarath, Astika Sewcharran, Amanda McIvor, Michael S. VanNieuwenhze, Ziyaad Waja, Neil Martinson, and Bavesh Davandra Kana
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differentially culturable tubercle bacteria ,tuberculosis ,Mycobacterium tuberculosis ,Beijing strains ,LAM strains ,Medicine - Abstract
Growing evidence points to the presence of differentially culturable tubercle bacteria (DCTB) in clinical specimens from individuals with active tuberculosis (TB) disease. These bacteria are unable to grow on solid media but can resuscitate in liquid media. Given the epidemiological success of certain clinical genotype families of Mycobacterium tuberculosis, we hypothesize that different strains may have distinct mechanisms of adaptation and tolerance. We used an in vitro carbon starvation model to determine the propensity of strains from lineages 2 and 4 that included the Beijing and LAM families respectively, to generate DCTB. Beijing strains were associated with a greater propensity to produce DCTB compared to LAM strains. Furthermore, LAM strains required culture filtrate (CF) for resuscitation whilst starved Beijing strains were not dependent on CF. Moreover, Beijing strains showed improved resuscitation with cognate CF, suggesting the presence of unique growth stimulatory molecules in this family. Analysis of starved Beijing and LAM strains showed longer cells, which with resuscitation were restored to a shorter length. Cell wall staining with fluorescent D-amino acids identified strain-specific incorporation patterns, indicating that cell surface remodeling during resuscitation was distinct between clinical strains. Collectively, our data demonstrate that M. tuberculosis clinical strains from different genotype lineages have differential propensities to generate DCTB, which may have implications for TB treatment success.
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- 2024
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44. Exploring the Client-Therapist Relationship in Music Therapy
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Denise Straume Hansen McIvor
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user perspective ,music therapy ,mental health ,client-therapist relationship ,trusting relationship ,power relations ,Music ,M1-5000 ,Psychology ,BF1-990 - Abstract
Introduction: Most of the existing literature on the therapeutic relationship in music therapy rests on the researcher’s point of view. Hence, there is a limited amount of research that focuses on what creates a helpful client-therapist relationship from the client’s perspective. This study aimed to explore what participants from various psychiatric units at different hospitals in Norway find to be helpful characteristics in the client-therapist relationship in music therapy. Method: Four participants were interviewed using in-depth semi-structured interviews focusing on their perspectives on what creates a helpful client-therapist relationship in music therapy. Through the use of interpretative phenomenological analysis, two superordinate themes, each with four following subordinate themes, were developed. Results: Two super-ordinate themes were developed, namely “Power relations” and “Feeling safe and being challenged.” The participants expressed that “to not feel judged,” “the use of layman’s language,” “informality, flexibility, and collaboration in treatment,” as well as “trust” and “honesty” are important elements for a helpful client-therapist relationship. Discussion: The findings presented in this article, are discussed in relation to theory from psychology, music therapy, and previous studies from the field of mental healthcare. All participants spoke about previous experiences of power imbalance in mental health care. The findings suggest that a relationship that is based on equality and mutual respect contributes to a feeling of trust – all of which are proposed as helpful characteristics in the client-therapist relationship in music therapy.
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- 2023
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45. Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine
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Peterson, Cristina D., Waataja, Jonathan J., Kitto, Kelley F., Erb, Samuel J., Verma, Harsha, Schuster, Daniel J., Churchill, Caroline C., Riedl, Maureen S., Belur, Lalitha R., Wolf, Daniel A., McIvor, R. Scott, Vulchanova, Lucy, Wilcox, George L., and Fairbanks, Carolyn A.
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- 2023
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46. Non-invasive intravenous administration of AAV9 transducing iduronate sulfatase leads to global metabolic correction and prevention of neurologic deficits in a mouse model of Hunter syndrome
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Laoharawee, Kanut, Podetz-Pedersen, Kelly M., Nguyen, Tam T., Singh, Sajya M., Smith, Miles C., Belur, Lalitha R., Low, Walter C., Kozarsky, Karen F., and McIvor, R. Scott
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- 2023
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47. An investigation into what role anti-Americanism plays in attracting Middle Eastern Arab Sunni men to Islamist extremism, in the contemporary era
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McIvor, Paul Anthony Rashid
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320.55 - Abstract
In order to address this research question at the appropriate length, breadth and depth, it has necessitated the use of texts and academic debates across 'time and space', both ancient and modern, crossing a range of disciplines and encompassing Western and Middle Eastern academic sources.
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- 2019
48. AAV-mediated gene transfer to colon-innervating primary afferent neurons
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Reshma Gore, Tina Esmail, Kelsey Pflepsen, Ezequiel Marron Fernandez de Velasco, Kelley F. Kitto, Maureen S. Riedl, Andrea Karlen, R. Scott McIvor, Christopher N. Honda, Carolyn A. Fairbanks, and Lucy Vulchanova
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AAV ,visceral ,nociception ,chemogenetic ,intrathecal ,colon ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components. In this study, we adapted a dual AAV approach, used for projection-specific transgene expression in the CNS, to explore the potential for targeted delivery of transgenes to primary afferent neurons innervating visceral organs. Focusing on the extrinsic sensory innervation of the mouse colon, we first characterized the extent of dual transduction following intrathecal delivery of one AAV9 vector and intracolonic delivery of a second AAV9 vector. We found that if the two AAV9 vectors were delivered one week apart, dorsal root ganglion (DRG) neuron transduction by the second vector was greatly diminished. Following delivery of the two viruses on the same day, we observed colocalization of the transgenes in DRG neurons, indicating dual transduction. Next, we delivered intrathecally an AAV9 vector encoding the inhibitory chemogenetic actuator hM4D(Gi) in a Cre-recombinase dependent manner, and on the same day injected an AAV9 vector carrying Cre-recombinase in the colon. DRG expression of hM4D(Gi) was demonstrated at the mRNA and protein level. However, we were unable to demonstrate selective inhibition of visceral nociception following hM4D(Gi) activation. Taken together, these results establish a foundation for development of strategies for targeted transduction of primary afferent neurons for neuromodulation of peripheral neural circuits.
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- 2023
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49. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort studyResearch in context
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Hamish J.C. McAuley, Rachael A. Evans, Charlotte E. Bolton, Christopher E. Brightling, James D. Chalmers, Annemarie B. Docherty, Omer Elneima, Paul L. Greenhaff, Ayushman Gupta, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Alex Horsley, Linzy Houchen-Wolloff, Caroline J. Jolley, Olivia C. Leavy, Nazir I. Lone, William D-C Man, Michael Marks, Dhruv Parekh, Krisnah Poinasamy, Jennifer K. Quint, Betty Raman, Matthew Richardson, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Sally J. Singh, Michael Steiner, Ai Lyn Tan, Louise V. Wain, Carly Welch, Julie Whitney, Miles D. Witham, Janet Lord, Neil J. Greening, K. Abel, H. Adamali, D. Adeloye, O. Adeyemi, R. Adrego, L.A. Aguilar Jimenez, S. Ahmad, N. Ahmad Haider, R. Ahmed, N. Ahwireng, M. Ainsworth, B. Al-Sheklly, A. Alamoudi, M. Ali, M. Aljaroof, A.M. All, L. Allan, R.J. Allen, L. Allerton, L. Allsop, P. Almeida, D. Altmann, M. Alvarez Corral, S. Amoils, D. Anderson, C. Antoniades, G. Arbane, A. Arias, C. Armour, L. Armstrong, N. Armstrong, D. Arnold, H. Arnold, A. Ashish, A. Ashworth, M. Ashworth, S. Aslani, H. Assefa-Kebede, C. Atkin, P. Atkin, R. Aul, H. Aung, L. Austin, C. Avram, A. Ayoub, M. Babores, R. Baggott, J. Bagshaw, D. Baguley, L. Bailey, J.K. Baillie, S. Bain, M. Bakali, M. Bakau, E. Baldry, D. Baldwin, M. Baldwin, C. Ballard, A. Banerjee, B. Bang, R.E. Barker, L. Barman, S. Barratt, F. Barrett, D. Basire, N. Basu, M. Bates, A. Bates, R. Batterham, H. Baxendale, H. Bayes, M. Beadsworth, P. Beckett, M. Beggs, M. Begum, P. Beirne, D. Bell, R. Bell, K. Bennett, E. Beranova, A. Bermperi, A. Berridge, C. Berry, S. Betts, E. Bevan, K. Bhui, M. Bingham, K. Birchall, L. Bishop, K. Bisnauthsing, J. Blaikely, A. Bloss, A. Bolger, C.E. Bolton, J. Bonnington, A. Botkai, C. Bourne, M. Bourne, K. Bramham, L. Brear, G. Breen, J. Breeze, A. Briggs, E. Bright, C.E. Brightling, S. Brill, K. Brindle, L. Broad, A. Broadley, C. Brookes, M. Broome, A. Brown, J. Brown, J.S. Brown, M. Brown, V. Brown, T. Brugha, N. Brunskill, M. Buch, P. Buckley, A. Bularga, E. Bullmore, L. Burden, T. Burdett, D. Burn, G. Burns, A. Burns, J. Busby, R. Butcher, A. Butt, S. Byrne, P. Cairns, P.C. Calder, E. Calvelo, H. Carborn, B. Card, C. Carr, L. Carr, G. Carson, P. Carter, A. Casey, M. Cassar, J. Cavanagh, M. Chablani, T. Chalder, J.D. Chalmers, R.C. Chambers, F. Chan, K.M. Channon, K. Chapman, A. Charalambou, N. Chaudhuri, A. Checkley, J. Chen, Y. Cheng, L. Chetham, C. Childs, E.R. Chilvers, H. Chinoy, A. Chiribiri, K. Chong-James, G. Choudhury, N. Choudhury, P. Chowienczyk, C. Christie, M. Chrystal, D. Clark, C. Clark, J. Clarke, S. Clohisey, G. Coakley, Z. Coburn, S. Coetzee, J. Cole, C. Coleman, F. Conneh, D. Connell, B. Connolly, L. Connor, A. Cook, B. Cooper, J. Cooper, S. Cooper, D. Copeland, T. Cosier, M. Coulding, C. Coupland, E. Cox, T. Craig, P. Crisp, D. Cristiano, M.G. Crooks, A. Cross, I. Cruz, P. Cullinan, D. Cuthbertson, L. Daines, M. Dalton, P. Daly, A. Daniels, P. Dark, J. Dasgin, A. David, C. David, E. Davies, F. Davies, G. Davies, G.A. Davies, K. Davies, M.J. Davies, J. Dawson, E. Daynes, A. De Soyza, B. Deakin, A. Deans, C. Deas, J. Deery, S. Defres, A. Dell, K. Dempsey, E. Denneny, J. Dennis, A. Dewar, R. Dharmagunawardena, N. Diar-Bakerly, C. Dickens, A. Dipper, S. Diver, S.N. Diwanji, M. Dixon, R. Djukanovic, H. Dobson, S.L. Dobson, A.B. Docherty, A. Donaldson, T. Dong, N. Dormand, A. Dougherty, R. Dowling, S. Drain, K. Draxlbauer, K. Drury, H.J.C. Drury, P. Dulawan, A. Dunleavy, S. Dunn, C. Dupont, J. Earley, N. Easom, C. Echevarria, S. Edwards, C. Edwardson, H. El-Taweel, A. Elliott, K. Elliott, Y. Ellis, A. Elmer, O. Elneima, D. Evans, H. Evans, J. Evans, R. Evans, R.A. Evans, R.I. Evans, T. Evans, C. Evenden, L. Evison, L. Fabbri, S. Fairbairn, A. Fairman, K. Fallon, D. Faluyi, C. Favager, T. Fayzan, J. Featherstone, T. Felton, J. Finch, S. Finney, J. Finnigan, L. Finnigan, H. Fisher, S. Fletcher, R. Flockton, M. Flynn, H. Foot, D. Foote, A. Ford, D. Forton, E. Fraile, C. Francis, R. Francis, S. Francis, A. Frankel, E. Fraser, R. Free, N. French, X. Fu, J. Fuld, J. Furniss, L. Garner, N. Gautam, J.R. Geddes, J. George, P. George, M. Gibbons, M. Gill, L. Gilmour, F. Gleeson, J. Glossop, S. Glover, N. Goodman, C. Goodwin, B. Gooptu, H. Gordon, T. Gorsuch, M. Greatorex, P.L. Greenhaff, W. Greenhalf, A. Greenhalgh, N.J. Greening, J. Greenwood, H. Gregory, R. Gregory, D. Grieve, D. Griffin, L. Griffiths, A.-M. Guerdette, B. Guillen Guio, M. Gummadi, A. Gupta, S. Gurram, E. Guthrie, Z. Guy, H.H. Henson, K. Hadley, A. Haggar, K. Hainey, B. Hairsine, P. Haldar, I. Hall, L. Hall, M. Halling-Brown, R. Hamil, A. Hancock, K. Hancock, N.A. Hanley, S. Haq, H.E. Hardwick, E. Hardy, T. Hardy, B. Hargadon, K. Harrington, E. Harris, V.C. Harris, E.M. Harrison, P. Harrison, N. Hart, A. Harvey, M. Harvey, M. Harvie, L. Haslam, M. Havinden-Williams, J. Hawkes, N. Hawkings, J. Haworth, A. Hayday, M. Haynes, J. Hazeldine, T. Hazelton, L.G. Heaney, C. Heeley, J.L. Heeney, M. Heightman, S. Heller, M. Henderson, L. Hesselden, M. Hewitt, V. Highett, T. Hillman, T. Hiwot, L.P. Ho, A. Hoare, M. Hoare, J. Hockridge, P. Hogarth, A. Holbourn, S. Holden, L. Holdsworth, D. Holgate, M. Holland, L. Holloway, K. Holmes, M. Holmes, B. Holroyd-Hind, L. Holt, A. Hormis, A. Horsley, A. Hosseini, M. Hotopf, L. Houchen-Wolloff, K. Howard, L.S. Howard, A. Howell, E. Hufton, A.D. Hughes, J. Hughes, R. Hughes, A. Humphries, N. Huneke, E. Hurditch, J. Hurst, M. Husain, T. Hussell, J. Hutchinson, W. Ibrahim, F. Ilyas, J. Ingham, L. Ingram, D. Ionita, K. Isaacs, K. Ismail, T. Jackson, J. Jacob, W.Y. James, W. Jang, C. Jarman, I. Jarrold, H. Jarvis, R. Jastrub, B. Jayaraman, R.G. Jenkins, P. Jezzard, K. Jiwa, C. Johnson, S. Johnson, D. Johnston, C.J. Jolley, D. Jones, G. Jones, H. Jones, I. Jones, L. Jones, M.G. Jones, S. Jones, S. Jose, T. Kabir, G. Kaltsakas, V. Kamwa, N. Kanellakis, S. Kaprowska, Z. Kausar, N. Keenan, S. Kelly, G. Kemp, S. Kerr, H. Kerslake, A.L. Key, F. Khan, K. Khunti, S. Kilroy, B. King, C. King, L. Kingham, J. Kirk, P. Kitterick, P. Klenerman, L. Knibbs, S. Knight, A. Knighton, O. Kon, S. Kon, S.S. Kon, S. Koprowska, A. Korszun, I. Koychev, C. Kurasz, P. Kurupati, C. Laing, H. Lamlum, G. Landers, C. Langenberg, D. Lasserson, L. Lavelle-Langham, A. Lawrie, C. Lawson, A. Layton, A. Lea, O.C. Leavy, D. Lee, J.-H. Lee, E. Lee, K. Leitch, R. Lenagh, D. Lewis, J. Lewis, K.E. Lewis, V. Lewis, N. Lewis-Burke, X. Li, T. Light, L. Lightstone, W. Lilaonitkul, L. Lim, S. Linford, A. Lingford-Hughes, M. Lipman, K. Liyanage, A. Lloyd, S. Logan, D. Lomas, N.I. Lone, R. Loosley, J.M. Lord, H. Lota, W. Lovegrove, A. Lucey, E. Lukaschuk, A. Lye, C. Lynch, S. MacDonald, G. MacGowan, I. Macharia, J. Mackie, L. Macliver, S. Madathil, G. Madzamba, N. Magee, M.M. Magtoto, N. Mairs, N. Majeed, E. Major, F. Malein, M. Malim, G. Mallison, W. D-C Man, S. Mandal, K. Mangion, C. Manisty, R. Manley, K. March, S. Marciniak, P. Marino, M. Mariveles, M. Marks, E. Marouzet, S. Marsh, B. Marshall, M. Marshall, J. Martin, A. Martineau, L.M. Martinez, N. Maskell, D. Matila, W. Matimba-Mupaya, L. Matthews, A. Mbuyisa, S. McAdoo, H. McAllister-Williams, A. McArdle, P. McArdle, D. McAulay, G.P. McCann, J. McCormick, W. McCormick, P. McCourt, L. McGarvey, C. McGee, K. Mcgee, J. McGinness, K. McGlynn, A. McGovern, H. McGuinness, I.B. McInnes, J. McIntosh, E. McIvor, K. McIvor, L. McLeavey, A. McMahon, M.J. McMahon, L. McMorrow, T. Mcnally, M. McNarry, J. McNeill, A. McQueen, H. McShane, C. Mears, C. Megson, S. Megson, P. Mehta, J. Meiring, L. Melling, M. Mencias, D. Menzies, M. Merida Morillas, A. Michael, C. Miller, L. Milligan, C. Mills, G. Mills, N.L. Mills, L. Milner, S. Misra, J. Mitchell, A. Mohamed, N. Mohamed, S. Mohammed, P.L. Molyneaux, W. Monteiro, S. Moriera, A. Morley, L. Morrison, R. Morriss, A. Morrow, A.J. Moss, P. Moss, K. Motohashi, N. Msimanga, E. Mukaetova-Ladinska, U. Munawar, J. Murira, U. Nanda, H. Nassa, M. Nasseri, A. Neal, R. Needham, P. Neill, S. Neubauer, D.E. Newby, H. Newell, T. Newman, J. Newman, A. Newton-Cox, T. Nicholson, D. Nicoll, A. Nikolaidis, C.M. Nolan, M.J. Noonan, C. Norman, P. Novotny, J. Nunag, L. Nwafor, U. Nwanguma, J. Nyaboko, C. O'Brien, K. O'Donnell, D. O'Regan, L. O’Brien, N. Odell, G. Ogg, O. Olaosebikan, C. Oliver, Z. Omar, P.J.M. Openshaw, L. Orriss-Dib, L. Osborne, R. Osbourne, M. Ostermann, C. Overton, J. Owen, J. Oxton, J. Pack, E. Pacpaco, S. Paddick, S. Painter, A. Pakzad, S. Palmer, P. Papineni, K. Paques, K. Paradowski, M. Pareek, D. Parekh, H. Parfrey, C. Pariante, S. Parker, M. Parkes, J. Parmar, S. Patale, B. Patel, M. Patel, S. Patel, D. Pattenadk, M. Pavlides, S. Payne, L. Pearce, J.E. Pearl, D. Peckham, J. Pendlebury, Y. Peng, C. Pennington, I. Peralta, E. Perkins, Z. Peterkin, T. Peto, N. Petousi, J. Petrie, P. Pfeffer, J. Phipps, J. Pimm, K. Piper Hanley, R. Pius, H. Plant, S. Plein, T. Plekhanova, M. Plowright, K. Poinasamy, O. Polgar, L. Poll, J.C. Porter, J. Porter, S. Portukhay, N. Powell, A. Prabhu, J. Pratt, A. Price, C. Price, D. Price, L. Price, A. Prickett, J. Propescu, S. Prosper, S. Pugmire, S. Quaid, J. Quigley, J. Quint, H. Qureshi, I.N. Qureshi, K. Radhakrishnan, N.M. Rahman, M. Ralser, B. Raman, A. Ramos, H. Ramos, J. Rangeley, B. Rangelov, L. Ratcliffe, P. Ravencroft, A. Reddington, R. Reddy, A. Reddy, H. Redfearn, D. Redwood, A. Reed, M. Rees, T. Rees, K. Regan, W. Reynolds, C. Ribeiro, A. Richards, E. Richardson, M. Richardson, P. Rivera-Ortega, K. Roberts, E. Robertson, E. Robinson, L. Robinson, L. Roche, C. Roddis, J. Rodger, A. Ross, G. Ross, J. Rossdale, A. Rostron, A. Rowe, A. Rowland, J. Rowland, M.J. Rowland, S.L. Rowland-Jones, K. Roy, M. Roy, I. Rudan, R. Russell, E. Russell, G. Saalmink, R. Sabit, E.K. Sage, T. Samakomva, N. Samani, C. Sampson, K. Samuel, R. Samuel, A. Sanderson, E. Sapey, D. Saralaya, J. Sargant, C. Sarginson, T. Sass, N. Sattar, K. Saunders, R.M. Saunders, P. Saunders, L.C. Saunders, H. Savill, W. Saxon, A. Sayer, J. Schronce, W. Schwaeble, J.T. Scott, K. Scott, N. Selby, M.G. Semple, M. Sereno, T.A. Sewell, A. Shah, K. Shah, P. Shah, M. Shankar-Hari, M. Sharma, C. Sharpe, M. Sharpe, S. Shashaa, A. Shaw, K. Shaw, V. Shaw, A. Sheikh, S. Shelton, L. Shenton, K. Shevket, A. Shikotra, J. Short, S. Siddique, S. Siddiqui, J. Sidebottom, L. Sigfrid, G. Simons, J. Simpson, N. Simpson, A. Singapuri, C. Singh, S. Singh, S.J. Singh, D. Sissons, J. Skeemer, K. Slack, A. Smith, D. Smith, S. Smith, J. Smith, L. Smith, M. Soares, T.S. Solano, R. Solly, A.R. Solstice, T. Soulsby, D. Southern, D. Sowter, M. Spears, L.G. Spencer, F. Speranza, L. Stadon, S. Stanel, N. Steele, M. Steiner, D. Stensel, G. Stephens, L. Stephenson, M. Stern, I. Stewart, R. Stimpson, S. Stockdale, J. Stockley, W. Stoker, R. Stone, W. Storrar, A. Storrie, K. Storton, E. Stringer, S. Strong-Sheldrake, N. Stroud, C. Subbe, C.L. Sudlow, Z. Suleiman, C. Summers, C. Summersgill, D. Sutherland, D.L. Sykes, R. Sykes, N. Talbot, A.L. Tan, L. Tarusan, V. Tavoukjian, A. Taylor, C. Taylor, J. Taylor, A. Te, H. Tedd, C.J. Tee, J. Teixeira, H. Tench, S. Terry, S. Thackray-Nocera, F. Thaivalappil, B. Thamu, D. Thickett, C. Thomas, D.C. Thomas, S. Thomas, A.K. Thomas, T. Thomas-Woods, T. Thompson, A.A.R. Thompson, T. Thornton, M. Thorpe, R.S. Thwaites, J. Tilley, N. Tinker, G.F. Tiongson, M. Tobin, J. Tomlinson, C. Tong, M. Toshner, R. Touyz, K.A. Tripp, E. Tunnicliffe, A. Turnbull, E. Turner, S. Turner, V. Turner, K. Turner, S. Turney, L. Turtle, H. Turton, J. Ugoji, R. Ugwuoke, R. Upthegrove, J. Valabhji, M. Ventura, J. Vere, C. Vickers, B. Vinson, E. Wade, P. Wade, L.V. Wain, T. Wainwright, L.O. Wajero, S. Walder, S. Walker, E. Wall, T. Wallis, S. Walmsley, J.A. Walsh, S. Walsh, L. Warburton, T.J.C. Ward, K. Warwick, H. Wassall, S. Waterson, E. Watson, L. Watson, J. Watson, J. Weir McCall, C. Welch, H. Welch, B. Welsh, S. Wessely, S. West, H. Weston, H. Wheeler, S. White, V. Whitehead, J. Whitney, S. Whittaker, B. Whittam, V. Whitworth, A. Wight, J. Wild, M. Wilkins, D. Wilkinson, B. Williams, N. Williams, J. Williams, S.A. Williams-Howard, M. Willicombe, G. Willis, J. Willoughby, A. Wilson, D. Wilson, I. Wilson, N. Window, M. Witham, R. Wolf-Roberts, C. Wood, F. Woodhead, J. Woods, D.G. Wootton, J. Wormleighton, J. Worsley, D. Wraith, C. Wrey Brown, C. Wright, L. Wright, S. Wright, J. Wyles, I. Wynter, M. Xu, N. Yasmin, S. Yasmin, T. Yates, K.P. Yip, B. Young, S. Young, A. Young, A.J. Yousuf, A. Zawia, L. Zeidan, B. Zhao, B. Zheng, and O. Zongo
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COVID-19 ,Physical frailty ,Long-COVID ,Fried's frailty phenotype ,Hospitalisation ,Medicine (General) ,R5-920 - Abstract
Summary: Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK (PHOSP-COVID). The burden of frailty was objectively measured using Fried's Frailty Phenotype (FFP). The primary outcome was the prevalence of each FFP group—robust (no FFP criteria), pre-frail (one or two FFP criteria) and frail (three or more FFP criteria)—at 5 months and 1 year after discharge from hospital. For inclusion in the primary analysis, participants required complete outcome data for three of the five FFP criteria. Longitudinal changes across frailty domains are reported at 5 months and 1 year post-hospitalisation, along with risk factors for frailty status. Patient-perceived recovery and health-related quality of life (HRQoL) were retrospectively rated for pre-COVID-19 and prospectively rated at the 5 month and 1 year visits. This study is registered with ISRCTN, number ISRCTN10980107. Findings: Between March 5, 2020, and March 31, 2021, 2419 participants were enrolled with FFP data. Mean age was 57.9 (SD 12.6) years, 933 (38.6%) were female, and 429 (17.7%) had received invasive mechanical ventilation. 1785 had measures at both timepoints, of which 240 (13.4%), 1138 (63.8%) and 407 (22.8%) were frail, pre-frail and robust, respectively, at 5 months compared with 123 (6.9%), 1046 (58.6%) and 616 (34.5%) at 1 year. Factors associated with pre-frailty or frailty were invasive mechanical ventilation, older age, female sex, and greater social deprivation. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. Interpretation: Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although two-thirds of the population remained pre-frail or frail. This suggests comprehensive assessment and interventions targeting pre-frailty and frailty beyond the initial illness are required. Funding: UK Research and Innovation and National Institute for Health Research.
- Published
- 2023
- Full Text
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50. Aboriginal men's programs tackling family violence: A scoping review
- Author
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Gallant, David, Andrews, Shawana, Humphreys, Cathy, Diemer, Kristin, Ellis, David, Burton, John, Harrison, Wally, Briggs, Ron, Black, Carly, Bamblett, Alfie, Torres-Carne, Steven, and McIvor, Robyn
- Published
- 2017
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