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Business schools seek to prepare students for the workplace with employer-valued skills such as communication, teamwork, and application of knowledge. As such, a common practice for business and management educators is to involve students in collaborative team-based assignments and community projects. For example, to facilitate the development of teamwork skills, faculty members may have students create a team charter, which involves student teams identifying goals, roles, and norms. However, empirical evidence of the value of team charters is limited. This study examined student perceptions of team charters to determine if they played a role in effective teamwork or if other variables accounted for team success. The study entailed an analysis of a mid-semester team evaluation survey and an end-of-semester team charter survey. Findings indicated that overall, including the development and application of student charters in student group projects leads to several significant benefits and learning outcomes. However, the perceived usefulness of charters varies among students by level of experience and year in school.

Schools of business aim to help students develop employer-valued skills, which include communication, teamwork, critical thinking, and application of learning. This can be achieved through team assignments and community-based learning. Such approaches help students apply the concepts they are learning, collaborate with others, develop managerial skills, and solve real-life workplace issues. Teamwork is commonly thought to be enhanced when students establish a team charter outlining their goals, norms, and processes. Research on the value of team charters in business education, however, is limited. This study examined the role of team charters on student perceptions of working well together. Data was collected and analyzed from a mid-term team evaluation and a final team charter assessment. Findings indicated that perceived value of team charters differs across the year in school and tends to be higher for less experienced students. The provision of a structured project roadmap clarified team member roles, responsibilities, personal accountability, and team vision.

BACKGROUND: As many as 2.4 million Americans are affected by chronic Hepatitis C Virus (HCV) in the United States.In 2018, the estimated number of adults with a history of HCV infection in San Diego County was 55,354 (95% CI: 25,411-93,329). This corresponded to a seroprevalence of 2.1% (95% CI: 2.1-3.4%). One-third of infections were among PWID. Published research has demonstrated that direct-acting antivirals (DAAs) have high efficacy and can now be used by primary care providers to treat HCV. In addition, limited evidence exists to support the effectiveness of simplified algorithms in clinical trial and real-world settings. Even with expanded access to HCV treatment in primary care settings, there are still groups, especially people who inject drugs (PWID) and people experiencing homelessness, who experience treatment disparities due to access and treatment barriers. The current study extends the simplified algorithm with a streetside one-stop-shop approach with integrated care (including the offer of buprenorphine prescriptions and abscess care) using a mobile clinic situated adjacent to a syringe service program serving many homeless populations. Rates of HCV treatment initiation and retention will be compared between patients offered HCV care in a mobile clinic adjacent to a syringe services program (SSP) and homeless encampment versus those who are linked to a community clinics current practice of usual care, which includes comprehensive patient navigation. METHODS: A quasi-experimental, prospective, interventional, comparative effectiveness trial with allocation of approximately 200 patients who inject drugs and have chronic HCV to the simplified care pathway (intervention group) or the usual care pathway (control group). Block randomization will be performed with a 1:1 randomization. DISCUSSION: Previous research has demonstrated acceptable outcomes for patients treated using simplified algorithms for DAAs and point-of-care testing in mobile medical clinics; however, there are opportunities to explore how these new, innovative systems of care impact treatment initiation rates or other HCV care cascade outcomes among PWID. TRIAL REGISTRATION: We have registered our study with ClinicalTrials.gov, a resource of the United States National Library of Medicine. This database contains research studies from United States and other countries around the world. Our study has not been previously published. The ClinicalTrials.gov registration identifier is NCT04741750.

Students report experiencing elevated levels of academic stress while in Advanced Placement (AP) and International Baccalaureate Diploma (IBD) classes. In response, we developed a classwide, preventative coping and connectedness curriculum, which consists of 12 50-minute modules for 9th-grade students enrolled in accelerated coursework. In this pilot study, we implemented the curriculum in 2 schools and sought user feedback. After describing the curriculum, we examine the acceptability of this social-emotional curriculum at three stages: prior to, during, and following implementation. Overall, all stakeholders--including students, parents, and educators--deemed the curriculum highly acceptable. Teachers, administrators, and parents rated the content and lessons as highly acceptable for addressing students' academic stressors and development of necessary coping and strategies. Included is a discussion of these findings relative to prior acceptability research, including research with gifted learners, limitations, and the role of acceptability in the line of inquiry for this curriculum intervention development.

Abstract The dataset presents a 43 year-long reanalysis of pollen seasons for three major allergenic genera of trees in Europe: alder (Alnus), birch (Betula), and olive (Olea). Driven by the meteorological reanalysis ERA5, the atmospheric composition model SILAM predicted the flowering period and calculated the Europe-wide dispersion pattern of pollen for the years 1980–2022. The model applied an extended 4-dimensional variational data assimilation of in-situ observations of aerobiological networks in 34 European countries to reproduce the inter-annual variability and trends of pollen production and distribution. The control variable of the assimilation procedure was the total pollen release during each flowering season, implemented as an annual correction factor to the mean pollen production. The dataset was designed as an input to studies on climate-induced and anthropogenically driven changes in the European vegetation, biodiversity monitoring, bioaerosol modelling and assessment, as well as, in combination with intra-seasonal observations, for health-related applications.

Community-based learning (CBL) is a mutually beneficial partnership involving higher education institutions (HEIs), students, faculty, and the community. It provides students with the opportunity to apply academic concepts to real-life situations and community organizations with the opportunity to gain insights from evidence-based theories and current research. Significant changes for HEIs and businesses resulting from the COVID-19 pandemic, such as online course delivery, business lockdowns, telecommuting, and physical distancing, suggest a large potential impact on CBL practice and increased challenges for faculty members who manage CBL processes. This study explores the faculty perspective on CBL practices with a specific focus on the impact of COVID-19. Findings indicate that both institutions and faculty within them found innovative solutions for overcoming disruptions caused by the pandemic. The findings also indicate a range of practices related to support and training for CBL and overwhelming indicate strong faculty commitment to pedagogical approaches that deepen student learning while also benefiting local communities.

Agricultural price fluctuations impact the economy and society, highlighting the importance of price stability for sustainable development, poverty alleviation, food security, and economic stability. This issue is particularly pronounced in the cocoa industry, where volatile prices and inefficient supply chains often harm the livelihoods of cocoa farmers. This study aimed to develop a mitigation plan to address cocoa price volatility at the farm level. The study was conducted in Tubbi Taramanu Sub-district, Polewali Mandar District, Indonesia. Through the innovative use of Interpretative Structural Modeling (ISM), the key elements are delineated in their hierarchical relationships and categorized into four quadrants: autonomous, independent, dependent, and linkage, to formulate a strategy for stabilizing cocoa prices at the farm level. This research’s findings underscored the importance of reducing farmers’ dependency on middlemen as the primary strategy for mitigating fluctuations in cocoa bean prices at the farm level. This approach is particularly vital due to the excessive reliance on middlemen, a key driver of price instability at the farm level. Furthermore, it is evident that promoting and nurturing cooperation between farmers and cocoa industry stakeholders can prove highly effective and significant when fortified by the local government’s support through the implementation of appropriate public policies.

Contract farming is widely recognised as an empowering tool to improve the welfare of farmers in developing countries and as an institutional solution to address issues related to market failure, credit, insurance, and information. This research endeavours to scrutinise the socio-economic distinctions between farmers engaged in contract farming and those not involved in such agreements. Additionally, it seeks to identify the factors influencing farmers’ participation in contract farming schemes and assess the impact of such arrangements on the income of red chilli farmers. The study, conducted in Magelang District, included 40 respondents from contract farmers and 45 from non-contract farmers. Employing the probit model, the ordinary least square model, and the treatment effect by Heckman, the research aimed to estimate the income impacts of existing contract farming. The findings revealed a noteworthy 57.50% increase in farmers’ incomes attributed to enhanced productivity and effective product management within the context of contract farming. Moreover, contracted farmers demonstrated advanced socio-economic conditions, boasting higher levels of education, knowledge, productivity, and agricultural assets compared to their non-contracted counterparts.

Maize is a significant food crop in Indonesia’s agricultural development endeavors. In South Sulawesi Province, Bantaeng Regency is one of the regencies that developed corn farming with a large land area. This study aimed to examine the impact of input application on maize yield and assess the degree of efficiency and inefficiency in maize farming. The study was conducted in Bantaeng Regency, utilizing a sample size of 180 households engaged in maize farming as the primary data collection method. The data collected was analyzed using the Stochastic Frontier Cobb-Douglas Model, Technical Efficiency Analysis, Allocative Efficiency Analysis, Economic Efficiency Analysis, and Inefficiency Model. The findings indicated that the variables of land area, seed application, urea fertilizer, insecticide, and herbicide exhibited a significant positive impact on yields of maize. Conversely, the variable of NPK fertilizer had a significant negative impact. In the meantime, it is observed that the labor variable demonstrates a negative impact. The observed values in technical (0.544), allocative (1.840), and economic (1.001) suggest that maize cultivation has not attained technical, allocative, or economic efficiency. Meanwhile, it was also found that the variables significant positive to the technical inefficiency of maize farming are farming experience and education level. Therefore, in a short-term perspective, from a technical-managerial perspective, expanding the area of land under management, increasing the volume of seeds, urea fertilizer, insecticides, and herbicides to the optimum use is the right choice and an effective way for farmers to increase maize production. On the local government side, reviewing the price of certified seeds, subsidizing the price of maize seeds, ensuring the availability of urea and NPK fertilizers, insecticides, and herbicides, and intensifying extension activities and technical guidance on maize cultivation are alternative agricultural policies that the government can implement to support the efficiency and effectiveness of maize farming management.

Abstract Infectious diseases can cause considerable mortality in vertebrate populations, especially when a new pathogen emerges. Quantifying the impact of diseases on wild populations and dissecting the underlying mechanisms requires longitudinal individual monitoring combining demographic and epidemiologic data. Such longitudinal population studies are rare. Rabbit hemorrhagic disease (RHD) is one of the main causes of the decline in European wild rabbit (Oryctolagus cuniculus) populations. A new genotype of RHD virus (RHDV), called RHDV2 or GI.2, emerged in 2010, posing a new threat to previously weakened populations, particularly as this virus can infect individuals already immune to classical RHDV strains. Taking advantage of intensive monitoring from 2009 to 2014 by physical captures and microchip detections of a semi‐captive population of rabbits, we finely assessed the demographic impact of an initial RHDV2 outbreak that occurred in the population and identified the most affected demographic parameters. A multi‐event modeling analysis revealed decreased survival in both juveniles and adults in 2011 and 2012, suggesting an RHDV2 outbreak for two consecutive years. The short‐term survival benefit of vaccination against classical RHDV strains only during these years, and the recovery of carcasses with RHDV2 detection, supported this hypothesis. Variations in population vaccination coverage also explain the difference in adult survival between the two years of the outbreak. And the transient protective effect of vaccination could explain the prolonged duration of the outbreak. A brief episode of myxomatosis in 2011 seems to have had only a limited impact on the population. During outbreak years, in individuals not recently vaccinated, monthly juvenile survival crashed (0.55), and annual adult survival was three times lower than in normal years (0.21 vs. 0.69). The combination of successive juvenile and adult survival estimates for unvaccinated rabbits during the outbreak years resulted in a very low recruitment rate in the breeding population. Finally, RHDV2 outbreaks appear to have caused mortalities comparable to those caused by older classical RHDV strains and may have a strong demographic impact on wild populations of European rabbit. This work highlights the importance of long‐term observational and experimental studies to better understand the impact of epidemics on animal populations.

ABSTRACT Peru holds a high mammalian diversity in its Amazonian region, with 326 species. However, our knowledge about the actual diversity is still considered incomplete, and the molecular information for those species in genetic databases is even less comprehensive. To assess the availability of genetic information for Peruvian Amazonian mammals relative to known diversity, we surveyed the Amazonian mammals with at least one molecular marker in the most widely used repositories for nucleotide sequences, GenBank and BOLD Systems. Our survey focused on widely used molecular markers in evolutionary biology-cytochrome b [cyt-b], cytochrome oxidase I [COI], 12S ribosomal RNA [12S], and the mitogenome [mit]-derived from Peruvian Amazon mammals. Additionally, to gain insights into the current mammalian sampling effort in Peruvian Amazonia, we generated a map of unique sampling localities and a heat map, utilizing 41951 records, which identified six major information gaps. This comprehensive analysis found 1597 genetic sequences corresponding to 180 mammalian species (55.2% of Peruvian Amazonian species): COI (38 species), cyt-b (167 species), 12S (56 species), and mitogenome (16 species). Taxonomically, Rodentia (53 species, four markers), Chiroptera (63 species, three markers), and Didelphimorphia (27 species, four markers) represented most molecular data, with a concentration of molecular markers in the orders Chiroptera (703) and Rodentia (499). Geographically, the Loreto department has the largest genetic information (530 records, 99 species). These results confirm a worrying underrepresentation of Peruvian Amazonian diversity in molecular databases. Consequently, we advocate for the use of scientific collections as an alternative source to systematically generate genetic information for the Amazonian mammal diversity in Peru to compensate for the current underrepresentation.

Through a project undertaken under a programme funded by United Kingdom Research and Innovation (UKRI) called Transforming Education for Sustainable Futures (TESF), alternative learning approaches associated with the introduction of a form of vertical farming called ‘tower gardens’ at primary schools were explored. Methods that were new to the local education context were used to support the learning process, for example role-playing sketches that allowed learners to share their own knowledge about gardening activities with their peers, teachers and staff from the non-governmental organisation that facilitated the process. This collective sharing and recall were key elements of the social learning process, building into individual and group knowledge. Corroborated memory recall contributed to group learning and also built into the collective storage of knowledge. Learning was firmly embedded in social interaction, in collective symbolism and arts – music specifically. These forms of learning and storing of knowledge resonated with the learners as it was a continuation of life as they know it in their community. It became clear from the project that educators saw the value of introducing concepts from classroom subjects when constructing and managing the tower gardens and were pleasantly surprised by the responses of the learners to this new way of learning, suggesting that creating scope within the curriculum and schoolwork plan is necessary in tandem with building the required capacity to replicate this without external support.

Currently, two-level Mokken scale analysis for clustered test data is being developed. This paper contributes to this development by providing model-fit procedures for two-level Mokken scale analysis. New theoretical insights suggested that the existing model-fit procedure from traditional (one-level) Mokken scale analyses can be used for investigating model fit at both level 1 (respondent level) and level 2 (cluster level) of two-level Mokken scale analysis. However, the traditional model-fit procedure requires some modifications before it can be used at level 2. In this paper, we made these modifications and investigated the resulting model-fit procedure. For two model assumptions, monotonicity and invariant item ordering, we investigated the false-positive count and the sensitivity count of the level 2 model-fit procedure, with respect to the number of model violations detected, and the number of detected model violations deemed statistically significant. For monotonicity, the detection of model violations was satisfactory, but the significance test lacked power. For invariant item ordering, both aspects were satisfactory.

Abstract Background Nursing homes (NHs) have been particularly affected by COVID-19. The aim of this study is to estimate the burden of COVID-19 and to investigate factors associated with mortality during the first epidemic wave in a large French NHs network. Methods An observational cross-sectional study was conducted in September-October 2020. 290 NHs were asked to complete an online questionnaire covering the first epidemic wave on facilities and resident characteristics, number of suspected/confirmed COVID-19 deaths, and preventive/control measures taken at the facility level. Data were crosschecked using routinely collected administrative data on the facilities. The statistical unit of the study was the NH. Overall COVID-19 mortality rate was estimated. Factors associated with COVID-19 mortality were investigated using a multivariable multinomial logistic regression. The outcome was classified in 3 categories: “no COVID-19 death in a given NH”, occurrence of an “episode of concern” (at least 10% of the residents died from COVID-19), occurrence of a “moderate episode” (deaths of COVID-19, less than 10% of the residents). Results Of the 192 (66%) participating NHs, 28 (15%) were classified as having an “episode of concern”. In the multinomial logistic regression, moderate epidemic magnitude in the NHs county (adjusted OR = 9.3; 95%CI=[2.6–33.3]), high number of healthcare and housekeeping staff (aOR = 3.7 [1.2–11.4]) and presence of an Alzheimer’s unit (aOR = 0.2 [0.07–0.7]) were significantly associated with an “episode of concern”. Conclusions We found a significant association between the occurrence of an “episode of concern” in a NH and some of its organizational characteristics and the epidemic magnitude in the area. These results can be used to improve the epidemic preparedness of NHs, particularly regarding the organization of NHs in small units with dedicated staff. Brief summary Factors associated with COVID-19 mortality and preventive measures taken in nursing homes in France during the first epidemic wave.

Road traffic related death and injury continues to be a major challenge globally. Unsafe road use is particularly evident in low- and middle-income countries while also being a growing concern for private sector organisations. The Safe System approach is recognized internationally as the leading approach to improving road safety and previous work has codified the essential management functions and interventions evident in its successful implementation. Tracking the development of Safe System adoption within the public and private sectors is of interest for several reasons. This paper presents recent development and use of road safety maturity frameworks and discusses the utility of these approaches for road safety practitioners and researchers.

ObjectiveDistal sensory polyneuropathy (DSP) and neuropathic pain are important clinical concerns in virally suppressed people with HIV. We determined how these conditions evolved, what factors influenced their evolution, and their clinical impact.MethodsAmbulatory, community-dwelling HIV seropositive individuals were recruited at six research centers. Clinical evaluations at baseline and 12 years later determined neuropathy signs and distal neuropathic pain (DNP). Additional assessments measured activities of daily living and quality of life (QOL). Factors potentially associated with DSP and DNP progression included disease severity, treatment, demographics, and co-morbidities. Adjusted odds ratios were calculated for follow-up neuropathy outcomes.ResultsOf 254 participants, 21.3% were women, 57.5% were non-white. Mean baseline age was 43.5 years. Polyneuropathy prevalence increased from 25.7% to 43.7%. Of 173 participants initially pain-free, 42 (24.3%) had incident neuropathic pain. Baseline risk factors for incident pain included unemployment (OR [95% CI], 5.86 [1.97, 17.4]) and higher baseline body mass index (BMI) (1.78 [1.03, 3.19] per 10-units). Participants with neuropathic pain at follow-up had significantly worse QOL and greater dependence in activities of daily living than those who remained pain-free.InterpretationHIV DSP and neuropathic pain increased in prevalence and severity over 12 years despite high rates of viral suppression. The high burden of neuropathy included disability and poor life quality. However, substantial numbers remained pain-free despite clear evidence of neuropathy on exam. Protective factors included being employed and having a lower BMI. Implications for clinical practice include promotion of lifestyle changes affecting reversible risk factors.

El aprendizaje del inglés, por su importancia desde el punto de vista cultural y su utilidad en la materialización de las más diversas relaciones que se establecen a nivel mundial, es una prioridad, por ello el presente artículo tiene como objetivo profundizar conceptualmente en la utilización de las tecnologías y las clases online, para desarrollar una propuesta que contribuya de una forma amena, motivadora y actualizada a la comunicación en idioma inglés. Fueron utilizados diferentes métodos, como el análisis, la síntesis, la revisión de documentos, observación, entrevistas, que permitieron arribar a conclusiones como la necesidad de estructuración de un proceso que atienda al aprendizaje del idioma inglés desde una perspectiva integral, con el soporte de las nuevas tecnologías y las clases online, para lograr una lógica en la enseñanza-aprendizaje de la expresión oral y al contexto, ideal para recibir y ofrecer ayudas y transitar gradualmente hacia una independencia lingüística y comunicativa.

Tujuan artikel ini adalah untuk mengetahui sistem pembelajaran dalam pengembangan karakter peserta didik di SDN 7 LAWANG. Pendidikan di sekolah sampai saat ini masih dipercaya sebagai media yang sangat ampuh dalam membangun kecerdasan, keterampilan dan kepribadian peserta didik. Sekolah merupakan suatu tempat yang mengelola dan menyelenggarakan kegiatan belajar yang memiliki konsistensi intensitas dan berkesinambungan agar transformasi ilmu menjadi tuntas, mengembangkan keperibadian dan karakter disekolah yang intensif merupakan usaha untuk membangkitkan dan meningkatkan kegiatan belajar secara efektif dalam menanamkan nilai dan karakter kepada setiap siswa. Pendekatan yang dapat diterapkan di sekolah dasar antara lain sebagai berikut: (1) Model Contextual Teaching and Learning (CTL), (2) Pendekatan Kontruktivisme, (3) Pendekatan Religi.

Abstract Effective wildlife monitoring and management are reliant on unbiased estimators of population parameters. Most standard survey approaches ignore spatial pattern in the data although spatial relationships can be leveraged to produce more efficient designs for future surveys, thereby reducing project cost. Landscape‐scale surveys for brown bears are notoriously expensive and difficult to complete, leading to the development of a non‐invasive mark–resight aerial survey approach as a practical alternative to more commonly employed approaches for estimating brown bear density across large areas. Here we extend that model to accommodate spatial covariate information and explicitly model residual spatial autocorrelation. Using brown bear survey data from northwestern Alaska, USA from 2015 to 2021, we demonstrate how our extension can be useful in exploring ecological factors related to spatial variation in bear density and detection probability. We found that detection probability was higher in more rugged terrain, and occurrence probability was higher at mid‐elevations where denning habitat was more prevalent and in areas with more salmon streams. The descriptive model of residual autocorrelation confirmed that additional unmeasured factors were associated with bear distribution. While these findings were not unexpected, they are very useful when considering future survey effort. Using this information, we explored a hypothetical redesign of the 2021 brown bear survey that removed 50% of the survey subunits with elevation values below the mean, where bears were least likely to occur. We demonstrated that the resulting estimates were unbiased, suggesting that adopting the spatial approach to analysis could reduce overall project costs by ~20%–30% going forward. Overall, our work indicates that directly accounting for spatial pattern within the non‐invasive mark–resight framework has substantive advantages over the original non‐spatial approach and may be useful in increasing the amount of information available for brown bear populations.

BackgroundPremenstrual dysphoric disorder (PMDD) is an understudied, debilitating disorder of women. Given evidence for prefrontal cortical and limbic dysfunction in PMDD, we compared intrinsic connectivity of the executive control network (ECN), default mode network (DMN), and amygdala in women with PMDD vs. controls.MethodsThirty-six women (18 PMDD, 18 control) participated in fMRI during the follicular and luteal phases of the menstrual cycle. At each time, resting-state functional connectivity was evaluated both before and after participants performed an emotion regulation task. The ECN was identified using independent components analysis, and connectivity of left and right amygdala seeds was also evaluated.ResultsNonparametric permutation testing identified a cluster in the left middle temporal gyrus (MTG) with significantly stronger connectivity to the left ECN in women with PMDD vs. controls in all four fMRI sessions. Women with PMDD exhibited no difference in functional connectivity between menstrual cycle phases. Amygdala connectivity did not differ between the groups but differed significantly with menstrual phase, with left amygdala connectivity to cingulate cortex being significantly stronger during the follicular vs. luteal phase. Right amygdala connectivity to the middle frontal gyrus was also stronger during the follicular vs. luteal phase, with no group differences. These findings suggest that women with PMDD have different intrinsic network dynamics in the left executive control network compared to healthy controls.

A variety of genetic techniques have been devised to determine cell lineage relationships during tissue development. Some of these systems monitor cell lineages spatially and/or temporally without regard to gene expression by the cells, whereas others correlate gene expression with the lineage under study. The GAL4 Technique for Real-time and Clonal Expression (G-TRACE) system allows for rapid, fluorescent protein-based visualization of both current and past GAL4 expression patterns and is therefore amenable to genome-wide expression-based lineage screens. Here we describe the results from such a screen, performed by undergraduate students of the University of California, Los Angeles (UCLA) Undergraduate Research Consortium for Functional Genomics (URCFG) and high school summer scholars as part of a discovery-based education program. The results of the screen, which reveal novel expression-based lineage patterns within the brain, the imaginal disc epithelia, and the hematopoietic lymph gland, have been compiled into the G-TRACE Expression Database (GED), an online resource for use by the Drosophila research community. The impact of this discovery-based research experience on student learning gains was assessed independently and shown to be greater than that of similar programs conducted elsewhere. Furthermore, students participating in the URCFG showed considerably higher STEM retention rates than UCLA STEM students that did not participate in the URCFG, as well as STEM students nationwide.

The objective of this article was to analyze the credit activity of the Popular and Solidarity Financial Sector of Ecuador in the first five-month period of 2021, according to the data generated by the Superintendency of Popular and Solidarity Economy with cuts to the months of January, February, March, April, and May of the same year. The figures of the loan portfolio by the segment of the popular and solidarity financial sector, by economic activity, as well as the distribution of the loan portfolio by segment, type of credit, sex, age range, and level of education were identified and analyzed, which made it possible to know the performance of the credit portfolio in this sector during the time analyzed.

This article presents initial results from excavations at Maritime Academy, Frindsbury, which produced several handaxes, two of which can be classed as 'giant handaxes'. Artefacts were recovered from fluvial deposits in the Medway Valley and are thought to date from the Marine Isotope Stage 9 interglacial. This article focuses on the largest of these handaxes and presents metrical data for the artefact and initial comparison with similar artefacts from the British Palaeolithic.

Secondary lesions and hemopathy localized in sternal bone may be responsible for persistent pain and resistant to classical analgesics. Surgical treatment is not applicable in these cases. We report on 2 cases of sternal osteosynthesis by internal cemented screw fixation, under fluoroscopy and CT scan control, without complication and with clear, immediate reduction of pain. Cementoplasty alone does not appear to be the most appropriate approach for treating lytic sternal lesions which are subject to traction and distraction forces, and resistant to analgesics. Discussion of these 2 cases demonstrate that internal cemented screw fixation allows for rapid management of pain in lytic lesions of the sternum in cancer-related context and should be more widespread in the medical community.

La dinámica escolar ha dependido del sector económico garantizando que el conocimiento circule, en la escuela, de manera homogénea, al ocultar sistemáticamente, las epistemes afrocolombianas que el Movimiento Social Afro ha protegido. De hecho, los planes de desarrollo definen el horizonte institucional al que se ve sujeto toda la ciudadanía, poniendo en tensión a las comunidades, sin tener en cuenta su concepción de desarrollo. El presente artículo, producto de una investigación en curso, visibiliza que a partir de la expedición de la Ley Páez se consolidó el modelo económico generando transformaciones de las concepciones educativas y curriculares causando impedimento para garantizar el respeto a la integridad étnica, cultural, ambiental, territorial y política, de las comunidades afronortecaucanas.

BackgroundDifficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD.MethodsOn the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems, eligible participants were assigned to two groups: PMDD and control (18 per group). Functional magnetic resonance imaging (fMRI) and a well-validated task were used to assess brain function during emotion regulation. Participants were tested twice, once during the follicular (asymptomatic) and once in the late luteal (symptomatic) phase of the menstrual cycle.ResultsWomen with PMDD gave higher ratings of negative affect in the luteal phase than in the follicular phase, and compared with healthy control participants during the luteal phase. A region-of-interest fMRI analysis indicated that during the late luteal phase, women with PMDD had hypoactivation in right dorsolateral prefrontal cortex (dlPFC) during all conditions of the emotion-regulation task, not only in the contrast that isolated emotion regulation. An exploratory whole-brain, voxel-wise analysis showed that women with PMDD had less activation in the precentral gyrus during the luteal phase than the follicular phase, and less activation in the postcentral gyrus compared with control participants.ConclusionsDuring the luteal phase of the menstrual cycle, women with PMDD experience difficulty regulating emotions. Hypoactivation in the right dlPFC may contribute to this problem, but may be related more generally to other affective symptoms of PMDD. Hypofunction in the right pre- and postcentral gyri warrants additional study.

Improved forest management (IFM) has the potential to remove and store large quantities of carbon from the atmosphere. Around the world, 293 IFM offset projects have produced 11% of offset credits by voluntary offset registries to date, channeling substantial climate mitigation funds into forest management projects. This paper summarizes the state of the scientific literature for key carbon offset quality criteria—additionality, baselines, leakage, durability, and forest carbon accounting—and discusses how well currently used IFM protocols align with this literature. Our analysis identifies important areas where the protocols deviate from scientific understanding related to baselines, leakage, risk of reversal, and the accounting of carbon in forests and harvested wood products, risking significant over-estimation of carbon offset credits. We recommend specific improvements to the protocols that would likely result in more accurate estimates of program impact, and identify areas in need of more research. Most importantly, more conservative baselines can substantially reduce, but not resolve, over-crediting risk from multiple factors.

Financial support is a critical enabling factor for healthy agri-food innovation systems, particularly within resource-limited settings, though additional forms of support are also necessary. This motivated a critical comparative review of evidence in peer-reviewed and gray literature on the range of instruments that support innovation in agri-food systems in the Global South, toward achieving sustainable agriculture intensification. The main aim is to provide recommendations to innovation managers on the choice of different instruments for supporting innovation. The key guiding questions for the comparative analysis were whether the instrument fosters uptake of innovation and whether it promotes inclusive development. A review of the literature was supplemented with a scan of websites for sources of peer-reviewed and gray literature documenting the application of the 12 selected instruments. The study revealed three categories of instruments: (Type A) those that support entrepreneurship; (Type B) those that primarily finance innovation; and (Type C) those that support innovation in real-life contexts. Our analysis indicates that innovation managers and funders need to select instruments that are likely to fit the specific context as well as to address the mandates of their organizations, and in so doing, they must consider how to ensure the sustainability of their investments and meet the needs of their beneficiaries. This review represents one of a handful that have compared the use of multiple instruments across multiple continents in the Global South, and can serve as an important decision-making tool for investors and funders looking to invest in agri-food innovation systems.

This study aims to count the transaction costs on farms of hybrid corn of dry seeds and analyze the factors that the transaction costs affect on farms of hybrid corn of dry seeds at through UPJ. This research was conducted in the Gorontalo province with samples in Gorontalo disctrict and Boalemo and using ekononometric equation analysis as a method of analysis. The results showed that the value of the average transaction costs on farm of hybrid corn of dry seed sales amounted to Rp1.545.466,- per transaction on per farming, and the factors that affect significantly the fault tolerance of 5 percent to the transaction cost on farms of hybrid corn of dry seeds sales consist of the total production, regional market prices, technical labor wages, commissions and degradation rate. The conclusions in this study stated that the total transaction costs incurred the hybrid maize of dry seeds farmers on sales is still high enough to reduce farm income and the factors that the transaction cost affect on sales of hybrid corn of dry seeds significantly includes the total production, regional market prices, technical labor wages, commissions and degradation rate. Penelitian ini bertujuan untuk menghitung biaya transaksi usahatani jagung hibrida pipilan kering dan menganalisis faktor-faktor yang mempengaruhi biaya transaksi usahatani jagung hibrida pipilan kering melalui penjualan ke UPJ. Penelitian ini dilakukan di Provinsi Gorontalo dengan sampel kabupaten Gorontalo dan kabupaten Boalemo dengan menggunakan analisis persamaan ekononometrika sebagai metode analisisnya. Hasil penelitian menunjukkan bahwa besaran biaya transaksi ratarata penjualan jagung hibrida pipilan kering sebesar Rp1.545.466,- per transaksi per usahatani, serta terdapat faktor-faktor yang mempengaruhi secara signifikan pada toleransi kesalahan 5 persen terhadap biaya transaksi penjualan jagung pipilan kering yang meliputi total produksi, harga pasar regional, upah tenaga teknis, komisi dan nilai degradasi. Kesimpulan dalam penelitian ini menyatakan bahwa total biaya transaksi yang dikeluarkan petani atas penjualan jagung pipilan kering masih cukup tinggi sehingga memperkecil pendapatan usahatani jagung hibrida, serta faktor-faktor yang mempengaruhi biaya transaksi penjualan jagung hibrida pipilan kering secara signifikan meliputi total produksi, harga pasar regional, upah tenaga teknis, komisi dan nilai degradasi.

Cocoa is one of the important plantation commodities that plays a significant role in Indonesia's economy. CV. Putra Mataram is an industry in Polewali Mandar, South Sulawesi, that processes cocoa into Macoa chocolate products. The challenges faced by the company in developing Macoa chocolate products include its less strategic geographic location, limited labor during production and marketing, inadequate production equipment for small businesses, insufficient funding for large stock procurement, numerous competitors for Macoa chocolate products, lack of continuous supply of fermented cocoa beans, rising raw material costs, and unpredictable weather. This study aims to analyze the priority strategies suitable for developing Macoa chocolate products at CV. Putra Mataram in Polewali Mandar. The research methods used were TOWS and QSPM analysis. The results showed that the appropriate strategy for the business development of Macoa chocolate products at CV. Putra Mataram, based on the IE matrix, falls into cell II, with weighted scores from internal and external factors (2.97 and 3.23), placing CV. Putra Mataram in the "Hold and Maintain" position. This strategy indicates that the marketing activities of Macoa chocolate products require a "hold and maintain" approach. Based on the TOWS analysis, nine alternative strategies were identified. The priority strategies for developing Macoa chocolate products at CV. Putra Mataram, based on QSPM analysis, include improving the quality of Macoa chocolate products and expanding partnerships in various cities/regions. The highest total attractiveness score (TAS) for the SO strategy was 6.26. [ABSTRACT FROM AUTHOR]

Abstract Monitoring of airborne pollen concentrations provides an important source of information for the globally increasing number of hay fever patients. Airborne pollen is traditionally counted under the microscope, but with the latest developments in image recognition methods, automating this process has become feasible. A challenge that persists, however, is that many pollen grains cannot be distinguished beyond the genus or family level using a microscope. Here, we assess the use of Convolutional Neural Networks (CNNs) to increase taxonomic accuracy for airborne pollen. As a case study we use the nettle family (Urticaceae), which contains two main genera (Urtica and Parietaria) common in European landscapes which pollen cannot be separated by trained specialists. While pollen from Urtica species has very low allergenic relevance, pollen from several species of Parietaria is severely allergenic. We collect pollen from both fresh as well as from herbarium specimens and use these without the often used acetolysis step to train the CNN model. The models show that unacetolyzed Urticaceae pollen grains can be distinguished with > 98% accuracy. We then apply our model on before unseen Urticaceae pollen collected from aerobiological samples and show that the genera can be confidently distinguished, despite the more challenging input images that are often overlain by debris. Our method can also be applied to other pollen families in the future and will thus help to make allergenic pollen monitoring more specific.

Despite data supporting the rapid adoption of telehealth in the delivery of clinical care in North America, the implementation of telehealth visits in clinical research studies has faced critical barriers. These challenges include: (1) variations in state licensure requirements for telehealth; (2) disparities in access to telehealth among disadvantaged populations; (3) lack of consistency among individual Investigational Review Boards (IRBs). Each barrier prevents the systematic conversion of research protocols to include telehealth visits. The Parkinson’s Foundation and members of the Parkinson Study Group submit this Comment to highlight current challenges to implementing telehealth visits for clinical research studies. Our objective is to provide a consensus statement emphasizing the urgent need for regulators to standardize adoption of telehealth practices and to propose recommendations to reduce the burden for implementation in existing research study protocols.

Perú ha sido uno de los países más afectados por la pandemia de COVID-19. Luego de haber sufrido dos olas epidémicas devastadoras, el departamento de emergencia del Hospital Nacional Edgardo Rebagliati Martins mantuvo como reto la preparación, de forma constante y dinámica, para afrontar una tercera ola que ya azotó a muchos países del mundo. Para esto, el departamento se preparó en todos los ámbitos para contribuir a la reducción del impacto de la enfermedad, garantizando no solo la calidad en la atención, sino también la seguridad del personal de salud, modulando la carga laboral y mental generada por la sobredemanda de la pandemia. De esta manera, el departamento estuvo mejor preparado cuando ocurrió la tercera ola. En conclusión, la preparación constante y dinámica es fundamental para afrontar el aumento de casos; así como también, garantizar la seguridad y bienestar del personal de salud.

El ibis de la puna Plegadis ridgwayi, es una especie de Threskiornithidae que habita humedales andinos y realiza migraciones altitudinales hacia la costa. Datos propios, de GBIF, información bibliográfica y del Censo Neotropical de Aves Acuáticas (1992 a 2015) muestran que el ibis de la puna Plegadis ridgwayi se distribuye en Ecuador, Perú, Bolivia, Argentina y Chile, con las mayores densidades poblacionales en Perú y Bolivia en siete y tres localidades respectivamente, que acumulan más del 1% de la población biogeográfica. Se encuentran de 0 a 5000 m de altitud, con las mayores densidades entre 3000 a 4500 m y 0 a 500 m. La mayor incidencia de registros ocurre al sur y centro del Perú, así como costa del centro y norte del Perú. La ampliación de la distribución hacia el norte y costa peruana puede deberse a la disponibilidad ambiental y al deterioro de su hábitat andino. En cuatro humedales costeros del centro del Perú se registraron hasta 818 ibis en 2006, la gran mayoría en Pantanos de Villa y Paraíso. El número de migrantes costeros parece relacionado a la intensidad de sequías en la sierra del Perú central. La abundancia de ibis en el lago altoandino de Junín muestra una disminución histórica, con énfasis después de la sequía de 2004-2005. La expansión distribucional requiere investigar la posible hibridación con las otras especies del género antes alopátridas.

Premenstrual dysphoric disorder (PMDD) is a psychiatric disorder that causes serious impairments in the functioning and quality of life of affected women. Until recently, research efforts were somewhat hampered by the lack of formal diagnostic criteria, which have now been codified as a category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Better characterization of deficits in socioemotional functioning caused by PMDD may aid in improving treatment efforts. In this investigation, prospective symptom ratings, based on DSM-5 criteria, were used to measure PMDD symptoms in 36 women (18 with PMDD and 18 healthy controls). Two self-report inventories, the Emotion Regulation Questionnaire and the Difficulties in Emotion Regulation Scale, were used to measure ability to regulate emotions, and socioemotional functioning was measured by inventories of social connectedness, perceived stress, and affect. Potential relationships between ability to regulate emotion and PMDD symptom severity, as well as other measures of socioemotional functioning and affective state, were tested. Women with PMDD reported significantly more behavioral impulsivity and greater difficulties in regulating emotion and in socioemotional functioning. Cognitive or behavioral strategies to improve these problems may benefit women with PMDD and help to alleviate distress caused by this disorder.