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Erectile dysfunction (ED) is increasingly becoming more common in young healthy males and is attributed mainly to psychogenic causes in these patients. Recent studies have reported that ED could be secondary to pudendal nerve or artery entrapment. This perspective assessed the efficacy of laparoscopic pudendal nerve and artery decompression in young patients suffering from refractory ED, associated to a pudendal nerve entrapment syndrome. After excluding patients with psychological ED and venous leakage, five young male patients with a history of both ED and pudendal nerve entrapment syndrome diagnosed based on the Nantes criteria were recruited. Pudendal nerve and artery release was performed using a laparoscopic transperitoneal approach. International Index for Erectile Function (IIEF-5) and erectile hardness score (EHS) improved significantly in all patients, 3 months after surgery. Pudendal nerve and artery entrapment could be therefore a reversible cause of ED in young healthy males, and its treatment by laparoscopic pudendal nerve and artery decompression seems to be safe and effective.

The evidence for the existence of a common pathway for health issues in men is presented in this review. Several epidemiological studies have shown that conditions like cardiovascular diseases (CVD), metabolic syndrome, diabetes, lower urinary tract symptom (LUTS), erectile dysfunction (ED), prostate cancer, hypogonadism, depression and suicide can be associated as risk factors for each other. Thus, the risk of CVD is significantly increased in men with metabolic syndrome, ED, hypogonadism, prostate cancer and/or LUTS. In addition, the above mentioned conditions are more prevalent in atherosclerotic patients. In addition, growing evidence indicates that low androgen levels can cause metabolic syndrome. In addition, obesity, dyslipidaemia and diabetes can further reduce androgen levels potentiating their adverse effect. Low testosterone levels are also associated with a higher incidence of aggressive prostate cancer on biopsy and on definitive pathology, and lower probability of abiraterone response in the metastatic setting. Several recent studies point towards diffuse endothelial dysfunction and dysregulated pro-inflammatory state as the biological link between all these disorders. Our current hypothesis is that oxidative stress caused by these dysfunctions explains the pathogenesis of each of these conditions., SCOPUS: re.j, info:eu-repo/semantics/published

A 2 years old boy was admitted in our institution for abdominal mass. He presented a growing abdominal mass, associated with constipation, and recently complained of pain with walking. The computed tomography-scan showed a large mass of the retroperitoneum, compressing the right ureter with upper urinary tract dilation. The alphafoetoprotein (AFP) blood level was 7500 ng/mL.

Vesicoureteral reflux (VUR) represents nowadays a controversial issue regarding its diagnosis, screening and treatment for its potential renal damage is not clearly understood. We aim in this mini-review to study the pathogenesis of VUR mechanisms in order to understand its clinical presentation and then be able to evaluate evidence in its screening and diagnosis. Primary VUR is essentially related to short intravesical length of the ureter, while secondary reflux is more related to anatomic or neuro functional anomalies of the bladder. Prevalence of VUR is high in siblings and offspring of index patients making its genetic predisposition quite evident. Recommendations in evaluation of VUR in case of antenatal hydronephrosis or urinary tract infection (UTI) differ among experts and organizations with benefits and inconveniences to each attitude.

The presence of a renal agenesis with an ipsilateral seminal vesicle cyst and an ejaculatory duct obstruction is a rare congenital anomaly initially reported by Zinner in 1914. This anomaly can be responsible of perineal pain, hemospermia, hematuria, post-ejaculatory pain, urinary tract infection, infertility and lower urinary tract symptoms (LUTS).