Search

目的探讨治疗前炎性指标在卵巢癌患者预后中的作用，建立卵巢癌患者的便捷、准确的生存预测模型。方法回顾性分析2013年1月至2018年12月在广州市第一人民医院就诊的145例卵巢癌患者及同期60例卵巢良性肿瘤患者的临床、病理及随访资料。根据随访截止日期时患者的生存情况，将患者分成生存组（48例）和死亡组（97例），比较两组患者治疗前外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞与淋巴细胞计数比值（MLR）、单核细胞与淋巴细胞计数比值（NAR）水平，采用Cox回归分析明确影响卵巢癌患者生存的因素，用R软件建立列线图生存预测模型，并进行内部验证。结果NLR、PLR、MLR、NAR在卵巢癌患者中的中位数（四分位数间距）分别为2.98 （1.85， 5.55）、156.17 （110.38， 194.66）、0.28 （0.21， 0.42）、0.17 （0.13， 0.28）；四个指标在卵巢良性肿瘤患者中的中位数（四分位数间距）分别为1.94 （1.49， 3.65）、125.00 （109.38， 180.66）、0.09 （0.04， 0.19）、0.14 （0.11， 0.17）。卵巢癌患者四个指标均高于卵巢良性肿瘤患者，差异具有统计学差异（P ＜0.05）；卵巢癌生存亚组在年龄、FIGO分期、治疗前血清白蛋白水平（37.22±4.86）、NLR （3.12±2.00）、PLR （143.61±54.18）、MLR （0.30±0.17）、NAR ［0.14 （0.11， 0.18）］与死亡亚组的年龄、FIGO分期、治疗前血清白蛋白水平 （34.33±3.73）、NLR （5.38±2.29）、PLR （185.76±64.04）、MLR （0.41±0.19）、NAR ［0.56 （0.19， 0.61）］存在统计学差异（P ＜0.05）；多因素分析显示病理分型、腹水、淋巴结转移、NLR、PLR、NAR是卵巢癌患者5年生存的独立预测因素。列线图预测术后生存模型的C-index为 0.865（0.792，0.921），校准预测曲线和理想曲线拟合良好。结论病理分型、腹水、淋巴结转移、治疗前外周血的NLR、PLR、NAR值是卵巢癌患者预后的独立预测因素，以此为基础构建的列线图模型对卵巢癌患者术后生存情况有良好的预测价值。

【目的】探讨信号转导与转录激活因子4（STAT4）基因rs10181656及rs16833431位点多态性与子痫前期相关性 的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者（病例组）和179名健康孕妇（对照 组）的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】①rs10181656位点在病例组中C/C、C/G及G/ G基因型频率分别是35.96％、47.81％及16.23％，而对照组中的三种基因型的频率分别是46.37％、44.69％及8.94％，C/C、C/ G及G/G基因型频率在病例组和对照组中分布具有统计学差异（P = 0.031），C、G等位基因频率在病例组和对照组中分布具 有统计学差异（P = 0.009）；②rs16833431位点：三种基因型和C、T等位基因频率在病例组和对照组的分布无统计学意义 （P = 0.508，0.461）。【结论】STAT4基因rs10181656位点多态性与子痫前期相关，而rs16833431位点多态性与子痫前期发病 无关。

【目的】研究IGF1、IGF2和IGF1R、IGF2R的表达及与胃肠道间质瘤(GISTs)临床病理学特征的关系及其相互间的相关性。【方法】应用免疫组化SABC法检测55例胃肠道间质瘤中IGF1、IGF2和IGF1R、IGF2R的表达情况,结合临床病理学资料(性别、组织学分型、肿瘤直径、组织学分级及部位)分组比较并进行统计学分析。【结果】55例GISTs中IGF1、IGF2和IGF1R、IGF2R阳性表达率分别为61.8%(34/55)、49.1%(28/55)和10.9%(6/55)、18.2%(10/55)。不同肿瘤直径及组织学分级之间IGF1和IGF2的阳性率有显著性差异(P0.05)。IGF1和IGF2、IGF1R和IGF1、IGF1R和IGF2、IGF1R和IGF2R、IGF2R和IGF2的表达均呈正相关(P

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Isotopes is the property of Journal of Isotopes Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Isotopes is the property of Journal of Isotopes Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Space-Integrated-Ground Information Networks is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Telecommunications Science is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Forest & Environment is the property of Journal of Forest & Environment Editorial and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)