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Mega construction projects (MCPs) play an indispensable role in the process of urbanization and urban sustainable development, while their planning often faces challenges due to diverse public opinion. Therefore, strategies to improve public acceptance of MCP's are essential during planning and development stages of such projects. Drawing on the Social Cognitive Theory (SCT), this research investigated the determinants of public acceptance of MCPs. A comparative case study was conducted on two MCPs (Guanshan substation and Stage II of Metro Line 8) in Wuhan city, China, with 450 and 640 responses, respectively to a face-to-face questionnaire survey. Adopting Structural Equation Modeling (SEM) for hypothesis testing, the results showed differences between the acceptance levels of these two MCPs among the public. Moreover, the influencing pathways found to be different between the projects. This study revealed self-efficacy having no direct effect on public acceptance while perceived risks to have a significant direct effect on MCP with more perceived benefits. Hence, the mediating roles of different perceived benefit-risk on public acceptance were identified in this study. This research enriches the understanding of how internal and external factors affect public acceptance and highlights the multi-faceted roles of perceived benefit-risk from the different MCPs perspective. Therefore, the policy design for the development of MCPs should be with a view to developing "one project type, one policy" that are better suited to local conditions. In addition, scientific and appropriate communication tools are necessary to gain public support in future. [ABSTRACT FROM AUTHOR]

Objectives: Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and symptomatic patients infected with SARS‐CoV‐2. Methods: We collected clinical, laboratory and epidemiological records of patients hospitalised in a coronavirus field hospital in Wuhan. We performed qualitative detection of anti‐SARS‐CoV‐2 immunoglobulin M (IgM) and immunoglobulin G (IgG) using archived blood samples. Results: Of 214 patients with SARS‐CoV‐2, 26 (12%) were asymptomatic at hospital admission and during hospitalisation. Most asymptomatic patients were ≤ 60 years (96%) and females (65%) and had few comorbidities (< 16%). Serum levels of white and red blood cells were higher in asymptomatic than in symptomatic patients (P‐values < 0.05). During hospitalisation, IgG seroconversion was commonly observed in both asymptomatic and symptomatic patients (85% versus 94%, P‐value = 0.07); in contrast, IgM seroconversion was less common in asymptomatic than in symptomatic patients (31% versus 74%, P‐value < 0.001). The median time from the first virus‐positive screening to IgG or IgM seroconversion was significantly shorter in asymptomatic than in symptomatic patients (median: 7 versus 14 days, P‐value < 0.01). Furthermore, IgG/IgM seroconversion rates increased concomitantly with the clearance of SARS‐CoV‐2 in both asymptomatic and symptomatic patients. At the time of virus clearance, IgG/IgM titres and plasma neutralisation capacity were significantly lower in recovered asymptomatic than in recovered symptomatic patients (P‐values < 0.01). Conclusion: Asymptomatic and symptomatic patients exhibited different kinetics of IgG/IgM responses to SARS‐CoV‐2. Asymptomatic patients may transmit SARS‐CoV‐2, highlighting the importance of early diagnosis and treatment. [ABSTRACT FROM AUTHOR]

• The severity of COVID-19 in pediatric cases was milder than adults. • Children younger than 2 years were more susceptible to COVID-19. • The average length of stay and the time of SARS-CoV-2 clearance were 10.57 and 6.39 days, respectively. At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. We retrospectively summarized the characteristics, treatment and outcomes of pediatric cases in Wuhan Children's Hospital which was the only designated hospital for children with COVID-19 in Hubei Province. A Cox proportional hazards regression analysis was used to evaluate factors associated with clinical outcomes. As of February 29, 75 children had been discharged, of which only one was has severe pneumonia and one was critical cases. Children younger than 2 years were more susceptible to COVID-19. All patients have received interferon-α nebulization, and eight cases including the severe and critical cases were co-administrated ribavirin. Five patients with mild pneumonia were given arbidol. Twenty-three patients were given traditional Chinese medicine (TCM). The average length of stay (LOS) and the time of SARS-CoV-2 clearance were 10.57 and 6.39 days, respectively. None of the factors was associated with LOS or time of SARS-CoV-2 clearance. The severity of COVID-19 in pediatric cases were milder than adults. The efficacy of the antiviral therapy in children with COVID-19 remains to be evaluated. [ABSTRACT FROM AUTHOR]

Of 322 stool specimens collected from children with diarrhea from October 2005 through September 2006 in Wuhan, China, group A rotavirus was identified in 101 (31.4%). The most prevalent group A rotavirus genotype was G3P[8] (62.6%), followed by G1P[8](17.6%), G1+G3P[8](8.8%), G3P[4](6.6%), G1P[4](2.2%), and G9P[8](2.2%). The G9 strains were first detected in Wuhan. [ABSTRACT FROM AUTHOR]