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Preparing students to be critical thinkers and effective communicators is essential in today's multinational and technologically sophisticated environment. New electronic technologies provide opportunities for creating learning environments that extend the possibilities of "old" but still essential technologies: books, blackboards, and linear, one-way communication media. Such technologies contribute to engagement and meaningful learning in the higher education sector. Greater understanding in educational psychology and the effectiveness of educational interventions has motivated the development of various student-centred pedagogies (e.g. Problem-Based Learning [PBL]) addressing perceived shortcomings of traditional didactic instruction. PBL as a pedagogy promotes meaningful learning due largely to its power to stimulate critical, reflective and creative thinking. Can teaching staff, then, adopt technology-based approaches to create multi-disciplinary interactive PBL environments that enhance learning and excite students, inspiring them to take ownership of their own education? This paper presents a cross-case analysis of four cases that explore how classroom-based learning activities have been transferred to online formats in universities to improve critical thinking, problem-solving skills, and other learning attributes across a range of disciplines.

Interest and participation in science in schools has been declining for many years and there is a genuine need to rejuvenate interest in science at the high school level. One possible solution is the completion of challenging science projects which fulfill an authentic purpose in the community. This paper discusses the results of ongoing research into the establishment of a rural and regional Science Challenge which makes use of partnerships with local industries and community groups to encourage the development of authentic science projects. In the development of the Science Challenge, many issues are emerging in relation to teachers' work, resources, administration and school cultures. This paper reports on the preliminary findings and indicates directions for the future. (Contains 4 tables.)

The realisation to integrate science, ethics and morality is recognised with growing impetus in recent years (as noted with introducing the Australian Curriculum "Science as a Human Endeavour" strand), to develop sophisticated epistemologies of science, which includes an appreciation of the social context including ethical thinking. To fulfil the aim where pedagogy and curriculum enable students to integrate ideas about scientific issues and their own values, beliefs and ethics, educators need to understand how an individual naturally construes these issues. This paper is based on an investigation to address the need, in particular, how students construe genetic engineering issues as ethical issues and/or moral problems and how these values (faith/beliefs) influence their decision making regarding these issues, in a ten-week Year 10 biotechnology program in a faith-based school. Using an interpretative case study approach, a mixed method data collection and action research, analyses of instructional strategies, students' beliefs/values/attitudes and achievement outcomes were evaluated. The investigation is unique as it presents one of the few studies that incorporate faith values in the ethical frameworks, to explore the connection between cognitive learning, moral reasoning and moral development, and in the wider sense, between scientific literacy and ethical reasoning. It suggests that allegiance to belief systems and ideologies can sometimes override the influence of one's own sense of fairness in making decisions of moral rightness, and this has implications in mapping out curriculum for moral education and socio-scientific education.

Increasing the scientific literacy of Australians has become an educational priority in recent times. The "Science State--Smart State" initiative of the Queensland Government involves an action plan for improving science education that includes a Science for Life action. A desired outcome is for an increased understanding of the natural world so that responsible decisions concerning our future wellbeing can be made in an age of science and technology. Biotechnology is a technology that is having profound impact on our lives. This paper describes how 15-16 year old students and biology teachers revealed a mismatch in both attitudes and interests towards biotechnology between the students and teachers. The findings are of interest as the teachers are writing biotechnology into their work programs in response to new syllabus documents. The teacher's areas of interest did not match those of the students, possibly resulting in a curriculum the teachers want to teach, but the students do not want to learn. (Contains 4 tables and 2 figures.)

Background: When patient selection processes determine who can and cannot use healthcare there can be inequalities and inequities in individuals' opportunities to benefit. This paper evaluates the influence of a hospital selection process on opportunities to access outpatient cardiac rehabilitation (CR). Methods: A secondary data analysis was conducted on a cohort of inpatients (n = 2,375) who were all eligible for invitation to an Australian CR program. Eligibility was determined by hospital discharge diagnosis codes. Only invited patients could attend. Logistic regression analysis tested the extent to which individual patient characteristics were statistically significantly associated with the outcome 'invitation' after adjusting for cardiac disease and other factors. Results: Less than half of the eligible patients were invited to the CR program. After allowing for known factors that may have justified not being selected, there was bias towards inviting males, younger patients, married patients, and patients who nominated English as their preferred language. Conclusions: Health service managers typically monitor service utilisation patterns as indicators of access but often pay little attention to ways in which locally determined system factors influence access to care. The paper shows how a hospital selection process can unreasonably influence patients' opportunities to benefit from an evidence-based healthcare program. [ABSTRACT FROM AUTHOR]

Biotechnology is a rapidly expanding field of science that has led to the formation of a large number of companies that together form a significant sector within the Australian economy. Even though there has been considerable growth in the Australian biotechnology sector as a whole, a large percentage of Australian biotechnology firms are small and medium sized enterprises (SMEs) that suffer from a lack of funding and expertise. The development and management of effective strategic alliances are critical to the success and development of biotechnology firms as they provide opportunities to share resources and expertise, access funding and develop new ideas. However, developing and managing strategic alliances is fraught with difficulties which are compounded by size and resource asymmetries and the nature of the biotechnology market. In this paper, we identify the difficulties faced by biotechnology firms and examine the importance of knowledge management related to alliance formation and development with special reference to the Australian context. We examine the knowledge and expertise that are required to be effective in developing strategic alliances in the biotechnology sector and provide a framework for managing knowledge related to strategic alliances. We suggest that critical systems approaches, in particular creative holism, are needed to manage the various forms of knowledge associated with strategic alliances. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

This paper analyses Australian biotechnology initial public offerings and the role of media coverage during the issue period in explaining capital raising, sentiment and underpricing. This paper finds empirical support for the hypothesis that an issuing company that receives more press coverage during the listing process leaves significantly more money on the table than those who receive less coverage, a finding consistent with the presence of sentiment effects and hot issue periods.Journal of Commercial Biotechnology (2006) 13, 43–47. doi:10.1057/palgrave.jcb.3050033 [ABSTRACT FROM AUTHOR]

The Duboisia species, a group of plants native to Australia, have been historically valued for their pharmacological properties and have played a significant role in traditional medicine and pharmaceutical research. Persistent efforts are underway to enhance the efficacy of the active ingredient scopolamine, employing both conventional breeding methods and advanced biotechnology tools. The primary objective of this research was to establish a highly efficient method for isolating mesophyll protoplasts and facilitating their regeneration, thereby laying a robust foundation for the application of various advanced plant biotechnology tools in the pursuit of genetic enhancement. The mesophyll protoplast isolation process was developed for hybrid D. myoporoides × D. hopwoodii with careful optimisation of the following parameters: leaf strip size; incubation conditions; physical treatment; and enzyme concentration. The optimal parameters were combined in each individual step; the best enzyme concentration was determined to be 2% (w/v) cellulysin and 0.5% (w/v) macerase. Protoplast yield was found to be greatly affected by the enzyme concentrations. The isolated protoplasts were cultured at a density of 0.5 × 105 to best sustain the highest cell division (33.2%) and a microcalli induction frequency of 17.9%. After 40 days of culture in a modified KM8P medium at 25 °C in darkness, visible microcalli were transferred to a solidified Murashige and Skoog (MS) medium with 1 mg L−1 2,4-dichlorophenoxyacetic acid (2,4-D) for callus induction under a 16 h photoperiod. After 30 days of culture, compact organogenic calli were transferred into a solid MS medium with 6-benzylaminopurine (BA) alone or thidiazuron (TDZ) alone or in combination with BA or naphthalene acetic acid (NAA) for shoot regeneration. The maximum shoot regeneration frequency (63.3%) was observed in the medium with 1.5 mg L−1 TDZ alone. For the first time, a reliable protoplast isolation and regeneration system from mesophyll cells was established for Duboisia with high protoplast viability, successful microcalli formation, and intact plant regeneration. This innovation will significantly contribute towards the genetic enhancement of the Duboisia species. [ABSTRACT FROM AUTHOR]

Background: Calls have been made for governments to adopt a cohesive approach to rare diseases through the development of national plans. At present, Australia does not have a national plan for rare diseases. To progress such a plan an inaugural Australian Rare Diseases Symposium was held in Western Australia in April 2011. This paper describes the key issues identified by symposium attendees for the development of a national plan, compares these to the content of EUROPLAN and national plans elsewhere and discusses how the outcomes might be integrated for national planning. Methods: The symposium was comprised of a series of plenary sessions followed by workshops. The topics covered were; 1) Development of national plans for rare diseases; 2) Patient empowerment; 3) Patient care, support and management; 4) Research and translation; 5) Networks, partnerships and collaboration. All stakeholders within the rare diseases community were invited to participate, including: people affected by rare diseases such as patients, carers, and families; clinicians and allied health practitioners; social and disability services; researchers; patient support groups; industry (e.g. pharmaceutical, biotechnology and medical device companies); regulators and policy-makers. Results: All of these stakeholder groups were represented at the symposium. Workshop participants indicated the need for a national plan, a national peak body, a standard definition of 'rare diseases', education campaigns, lobbying of government, research infrastructure, streamlined whole-of-lifetime service provision, case co-ordination, early diagnosis, support for health professionals and dedicated funding. Conclusions: These findings are consistent with frameworks and initiatives being undertaken internationally (such as EUROPLAN), and with national plans in other countries. This implies that the development of an Australian national plan could plausibly draw on frameworks for plan development that have been proposed for use in other jurisdictions. The translation of the symposium outcomes to government policy (i.e. a national plan) requires the consideration of several factors such as the under-representation of some stakeholder groups (e.g. clinicians) and the current lack of evidence required to translate some of the symposium outcomes to policy options. The acquisition of evidence provides a necessary first step in a comprehensive planning approach. [ABSTRACT FROM AUTHOR]

This paper analyses what influences professionals’ beliefs on agricultural genetic engineering. A telephone survey was conducted in 2004 on Australian public agricultural professionals. Using an ordered probit regression, some of the significant key influences on overall beliefs were: age; research relevance; ethnicity; farm background; information and occupational effects; attitudes towards the current sustainability of conventional agriculture; attitudes towards agricultural research issues; and attitudes towards the individual aspects of genetic engineering. Somewhat surprisingly, subjective knowledge of genetic engineering was not a significant factor in influencing overall beliefs, although it did play a positive influence on some individual beliefs (such as the technology’s profitability benefits and that there is no need for more long-term research before further general release of genetically engineered products). However, more research on the links between actual knowledge and acceptance are needed before any definitive conclusions can be drawn. [ABSTRACT FROM AUTHOR]

This paper assesses growth models for biotechnology organisations, comparing the dynamics of company evolution in the previous decade with circumstances pertinent to the more recent market downturn and financial constraints. Using anecdotal evidence gained from senior executives in biotechnology companies in the USA, Australia and Europe, the author demonstrates how the utilisation of human talent has evolved over the past decade. The creative use of human capital for companies with limited financial means is discussed, in the context of the differing needs of organisations as they progress along the biotechnology life cycle. [ABSTRACT FROM AUTHOR]

The biotechnology industry in Australia is continuing to grow rapidly, providing many opportunities for those with the relevant skills and qualifications to enter the field. Biotechnologists play a vital role in the financial development of biotech firms due to their innovative capacity, which is why they need to receive interactive and entrepreneurial education to ensure their productivity. This study aimed to determine the impact of these educational methods on the innovative capacity of biotechnologists in Australia. Two hundred seventy-six biotechnologists from different research sectors and biotech companies in Australia were surveyed for this study. Data was collected and analyzed using various statistical tools. The results from the path analysis suggested the presence of a significant and positive impact of interactive learning and entrepreneurial education on the innovation capacity of biotechnologists. The findings from the study are useful from policy, managerial, and theoretical perspectives. [ABSTRACT FROM AUTHOR]

Public interest in assisted reproduction (AR) has remained high since the birth of the first 'test tube baby' in the United Kingdom in 1978. Australian scientists have been frontrunners in the development and implementation of reproductive technology and recently, there has been renewed debate about government funding and access to AR. This paper provides a timely overview of reproductive technology services in Australia and examines the body of social research on the impacts of this technology, particularly previous research on how women and their partners experience assisted reproduction procedures. The popular expectations of success are compared to the latest success rates. It is argued that there is a need for more social research to counterbalance the dominance of the biomedical aspects of AR, in particular, for more research into people's actual experiences of AR, expectations of the likelihood of success, access issues and on the general impact of involuntary childlessness. [ABSTRACT FROM AUTHOR]

A recent study assessed the investor performance of the Australian drug development biotech (DDB) sector over a 15-year period from 2003 to 2018. The current study builds on that research and extends the analysis to 2020, using a 10-year period starting 2010, to exclude the impact of the global financial crisis in 2008/09. Based on a value-weighted portfolio of all 41 DDB firms, the overall sector delivered a negative annualized return of -4.1%. Individual firm performance was also assessed using the compound annual growth rate (CAGR) in share price over the period as a measure of investor outcomes. On this basis 68% of firms produced negative CAGRs over the period, and of the 32% of firms that produced positive CAGRs, six firms produced CAGRs greater than 20% per annum and in three cases of recently-listed firms, the CAGR's were greater than 50%. Overall however, the sector overall delivered very poor investor returns and despite a relatively large number of listed biotech firms, Australian biotechnology continues to be small and weak in terms of its contribution to global biotechnology industrialization. As such it lacks the critical mass to grow a robust bioeconomy based on drug development, which remains the standard-bearer of biotechnology industrialization. [ABSTRACT FROM AUTHOR]

Australia is an interesting case study of biotechnology ecosystem development. Despite its distance from the US biotechnology superclusters, the country has had high expectations for its potential development into a biotechnology superpower. These expectations have not been met over the last two decades. Despite generous R&D tax incentives and a robust network of public research organizations (PROs), the local biotechnology industry has remained small and weak, without a single 'big biotech' emerging. Cluster analysis over 11 years of all private and public DBFs indicated that the PRO network output failed to translate to the development by the local biotech industry of drug candidates that could attract Big Pharma deals. Analysis of the investor returns over 15 years from all public drug development biotech firms (DDBs) showed that not a single firm produced attractive long-term investor returns and the sector overall generated negative returns for investors. Despite high promissory expectations, favorable government policies and an inflated view of the quality of the country's science output, Australia has failed to create a sustainable biotechnology ecosystem. Some of the reasons are identified and suggestions are offered for changes in government policy that could improve value creation by the local biotech sector. [ABSTRACT FROM AUTHOR]

Purpose: Ageing in place is one of the greatest desires of elderly people. Assistive digital technologies could potentially delay the institutionalization of the elderly people and allow them ageing in place. This study develops a population-wide cost estimating framework for adopting digital technologies that can improve the quality of life of elderly people through examining an Australian region. Methods: We developed a five-stage cost estimation framework, which involved progressive forecasting of elderly population and direct cost estimation methods. The forecasting and cost estimation models have been set for a 10-year period because the prediction accuracy from cross-sectional data is better in the short to medium term compared to the long-term. For cost estimation, we categorised the ageing population on the basis of the number of chronic diseases that they have contracted. Costs of assistive technologies were collected from open sources. The model has been tested in the Fitzroy and Central West, a regional area of Queensland in Australia. A stakeholder panel discussion in a workshop format was used to validate the appropriateness of the proposed framework and the study findings. Results: This study identified eight common chronic diseases with different comorbidity patterns in Australia. We also identified the required assistive technologies to assist patients with chronic diseases. This study estimated that annual per capita cost for technological intervention could range from AUD 4,169 to AUD 7,551 on the basis of different price margins of the technologies. Conclusion: The approach of categorising the aged cohorts on the basis of the number of chronic diseases helps estimate population-wide costs compared to using single technology intervention costs for a particular chronic disease cohort. The cost estimation framework and the method developed in this study can assist the government to estimate costs for ageing-in-place programs. [ABSTRACT FROM AUTHOR]

Planning for a re-emergent epidemic of smallpox requires surge capacity of space, resources and personnel within health systems. There are many uncertainties in such a scenario, including likelihood and size of an attack, speed of response and health system capacity. We used a model for smallpox transmission to determine requirements for hospital beds, contact tracing and health workers (HCWs) in Sydney, Australia, during a modelled epidemic of smallpox. Sensitivity analysis was done on attack size, speed of response and proportion of case isolation and contact tracing. We estimated 100638 clinical HCWs and 14595 public hospital beds in Sydney. Rapid response, case isolation and contact tracing are influential on epidemic size, with case isolation more influential than contact tracing. With 95% of cases isolated, outbreak control can be achieved within 100 days even with only 50% of contacts traced. However, if case isolation and contact tracing both fall to 50%, epidemic control is lost. With a smaller initial attack and a response commencing 20 days after the attack, health system impacts are modest. The requirement for hospital beds will vary from up to 4% to 100% of all available beds in best and worst case scenarios. If the response is delayed, or if the attack infects 10000 people, all available beds will be exceeded within 40 days, with corresponding surge requirements for clinical health care workers (HCWs). We estimated there are 330 public health workers in Sydney with up to 940,350 contacts to be traced. At least 3 million respirators will be needed for the first 100 days. To ensure adequate health system capacity, rapid response, high rates of case isolation, excellent contact tracing and vaccination, and protection of HCWs should be a priority. Surge capacity must be planned. Failures in any of these could cause health system failure, with inadequate beds, quarantine spaces, personnel, PPE and inability to manage other acute health conditions. [ABSTRACT FROM AUTHOR]

Machado Joseph Disease (MJD) (spinocerebellar ataxia 3) is a hereditary neurodegenerative disease causing progressive ataxia and loss of mobility. It is the most common spinocerebellar ataxia worldwide. Among Aboriginal families of Groote Eylandt and related communities across Australia’s Top End, MJD is estimated to be more prevalent than anywhere else in the world. This study explored lived experiences of individuals and families with MJD to determine what is important and what works best to keep walking and moving around. A collaborative qualitative exploratory study, drawing from constructivist grounded theory methods, was undertaken for data collection and analysis. Semi-structured in-depth interviews were conducted with individuals with MJD (n = 8) and their family members (n = 4) from the Groote Eylandt Archipelago where ~1500 Aboriginal people (Warnumamalya) live. Interviews were led by Warnumamalya community research partners in participants’ preferred language(s). Participants described their experience of living with MJD, from ‘knowing about MJD’, ‘protecting yourself from MJD’ and ‘adjusting to life with MJD’. While the specific importance of walking and moving around differed widely between participants, all perceived that walking and moving around enabled them to do what mattered most to them in life. ‘Staying strong on the inside and outside’ (physically, mentally, emotionally, spiritually) was perceived to work best to keep walking and moving around as long as possible. A framework that included personal and environmental strategies for staying strong emerged: ‘Exercising your body’, ‘having something important to do’, ‘keeping yourself happy’, ‘searching for good medicine’, ‘families helping each other’ and ‘going country’. This study, the first to explore lived experiences of MJD in Australia, highlights the importance of maintaining mobility as long as possible. Strategies perceived to work best address physical and psychosocial needs in an integrated manner. Services supporting families with MJD need flexibility to provide individualised, responsive and holistic care. [ABSTRACT FROM AUTHOR]

Highlights the annual AusBiotech conference held by the Australian biotechnology trade association in August 2003. Theme of the event; Status of the biotechnology sector in the country; Fund raising effort launched by a Californian venture capital group to invest in Australian biotechnology.

Freshwater macroalgae from the genus Oedogonium have recently been targeted for biomass applications; however, strains of Oedogonium for domestication have not yet been identified. Therefore, the objective of this study was to compare the performance of isolates of Oedogonium collected from multiple geographic locations under varying environmental conditions. We collected and identified wild-type isolates of Oedogonium from three geographic locations in Eastern Australia, then measured the growth of these isolates under a range of temperature treatments corresponding to ambient conditions in each geographic location. Our sampling identified 11 isolates of Oedogonium that could be successfully maintained under culture conditions. It was not possible to identify most isolates to species level using DNA barcoding techniques or taxonomic keys. However, there were considerable genetic and morphological differences between isolates, strongly supporting each being an identifiable species. Specific growth rates of species were high (>26% day−1) under 7 of the 9 temperature treatments (average tested temperature range: 20.9–27.7°C). However, the variable growth rates of species under lower temperature treatments demonstrated that some were better able to tolerate lower temperatures. There was evidence for local adaptation under lower temperature treatments (winter conditions), but not under higher temperature treatments (summer conditions). The high growth rates we recorded across multiple temperature treatments for the majority of species confirm the suitability of this diverse genus for biomass applications and the domestication of Oedogonium. [ABSTRACT FROM AUTHOR]

The Southwest Australian Floristic Region (SWAFR) is a plant biodiversity hotspot with a geographically isolated and predominantly endemic flora. Known threatening processes (i.e. excessive clearing of native vegetation, soil salinity, soil erosion and chronic weed infestation) combined with uncertain but potentially deleterious environmental (climate) changes pose great challenges for conservation and restoration efforts. With a paucity of nature reserves, in situ protection of species can be problematic. For many species, ex situ conservation becomes the only viable strategy for saving species from extinction via seed banking or living collections established through vegetative propagation, or tissue ( in vitro) culture methods. Development of specific in vitro protocols is necessary to successfully initiate culture lines, with considerable development of nutrient media, plant growth regulator regimes and incubation conditions required to optimise shoot regeneration and multiplication, especially with woody species of the SWAFR. In addition, integration of root induction and acclimatization stages has allowed significant improvements in speed and success of plant production of both endangered and difficult-to-propagate woody species. We contend that there is also considerable potential for expansion of alternative in vitro technologies such as somatic embryogenesis for difficult taxa to complement existing ex situ conservation and restoration strategies in biodiversity hotspots such as SWAFR. [ABSTRACT FROM AUTHOR]

Background: We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL) observed in clinical trials has been experienced by an Australian NHL patient population. Methods: NHL cases diagnosed in 1985-2004 in New South Wales (NSW) were followed-up to the end of 2004. Rituximab prescription data were obtained from Medicare Australia. Using a Poisson regression model adjusted for age group, sex, NHL subtype and time period (1990-1994, 1995-1999 and 2000-2004), we estimated excess risk of death after a diagnosis of NHL. To give context to the survival trend, trends in incidence and mortality were also estimated. Results: Compared with 1990-1994, after adjusting for age, sex and NHL subtype the relative excess risk of death was significantly lower (p < 0.0001) in 1995-1999 (0.89) and 2000-2004 (0.74). A sharp fall in mortality was observed from 2000 to 2004 (annual percentage change (APC) = -4.7, p = 0.009), while a small but significant rise in incidence was seen from 1990 to 2004 (APC = 0.5, p = 0.01). The number of times rituximab was dispensed in NSW increased rapidly from 1274 in 1999 to 9250 in 2004. Conclusion: It is likely that some benefit of adding rituximab to the standard chemotherapy for NHL has been experienced at the population level. [ABSTRACT FROM AUTHOR]

Marine biogeographers have long recognized broad east–west differentiation of marine communities across southern Australia, but few studies have explicitly assessed the site of disjunction or the factors potentially underlying this biodiversity. A recent, detailed phylogeographical and distributional study of the dispersive gastropod genus Nerita revealed an abrupt shift in species abundance across mainland Australia, apparently correlated with the site of an historical vicariant barrier: the Bassian Isthmus. In the current study I provide an independent assessment of this vicariant hypothesis by morphologically analysing over 3000 intertidal Nerita specimens from eight coastal sites around Tasmania. Consistent with the Bassian Isthmus hypothesis, the study reveals a dramatic east–west disjunction across north-east Tasmania. A survey of marine biogeographical literature reveals several additional examples supporting the east–west species turnover detected in Nerita. I discuss the role of contemporary oceanographic factors in preserving the biogeographical signature of marine vicariance, even in highly dispersive taxa. Based on recent marine connectivity data, the east–west disjunction in Nerita taxa can be interpreted as an historic vicariant pattern perpetuated by contemporary oceanographic conditions. The results of this study emphasize the potential importance of considering relative abundance data – rather than just species range data – in marine biogeographical analyses. As the observed disjunction is likely to have broad implications for Australia's marine biodiversity, it is imperative that conservation biologists incorporate such data in the design of marine protected areas. [ABSTRACT FROM AUTHOR]

Australia is largely accepted as an active biotech nation and claims the sixth position globally in the industry. A recent survey of the Australian biotechnology industry reported 370 biotechnology and 600 medical-device companies, most, if not all, products of Australia's academic research initiatives. The country presents a unique biotechnology landscape dominated by seed-stage companies and a handful of larger companies with validated technologies and/or products in development. The reason for this skewed distribution lies, in part, in Australia's funding infrastructure. This is characterised by a large and high-quality academic system that derives applied research support from numerous government incentives for seed funding without a critical mass of downstream venture capital or other financial support to fund continued growth. The unique challenges faced by Australian companies, such as visibility, distance to key markets and potential commercial collaborators and lack of development funding, have resulted in a number of strategies being implemented. These include efforts to raise money, often prematurely and very discounted, through public markets in Australia and/or partnerships around very early, very high-risk development-stage projects with US/European pharmaceutical or biotechnology companies. In addition, a recent strategy has been to merge with or acquire another Australian or overseas small company. [ABSTRACT FROM AUTHOR]