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204 results on '"de Jong, Marcus C."'

2. Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study

Author

de Bloeme , Christiaan M., Jansen, Robin W., Cardoen, Liesbeth, Göricke, Sophia, van Elst, Sabien, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H., Miller, Audra K., Maeder, Philippe, Uner, Ogul E., Hubbard, G. Baker, Grossniklaus, Hans, Boldt, H. Culver, Nichols, Kim E., Brennan, Rachel C., Sen, Saugata, Koob, Mériam, Sirin, Selma, Brisse, Hervé J., Galluzzi, Paolo, Dommering, Charlotte J., Cysouw, Matthijs, Boellaard, Ronald, Dorsman, Josephine C., Moll, Annette C., de Jong, Marcus C., and de Graaf, Pim

Published
2024
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3. Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

Author

Jansen, Robin W., Roohollahi, Khashayar, Uner, Ogul E., de Jong, Yvonne, de Bloeme, Christiaan M., Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J., Cardoen, Liesbeth, Castelijns, Jonas A., van der Valk, Paul, Moll, Annette C., Grossniklaus, Hans, Hubbard, G. Baker, de Jong, Marcus C., Dorsman, Josephine, and de Graaf, Pim

Published
2024
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7. Treatment evaluation by volumetric segmentation in pediatric optic pathway glioma: evaluation of the effect of bevacizumab on intra-tumor components

Author

Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Cancer, Bennebroek, Carlien A., Schouten, Christiaan R., Montauban-van Swijndregt, Maartje C., Saeed, Peerooz, Porro, Giorgio L., Pott, Jan W.R., Dittrich, Anne T.M., Oostenbrink, Rianne, Schouten-van Meeteren, Antoinette Y., de Jong, Marcus C., de Graaf, Pim, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Cancer, Bennebroek, Carlien A., Schouten, Christiaan R., Montauban-van Swijndregt, Maartje C., Saeed, Peerooz, Porro, Giorgio L., Pott, Jan W.R., Dittrich, Anne T.M., Oostenbrink, Rianne, Schouten-van Meeteren, Antoinette Y., de Jong, Marcus C., and de Graaf, Pim

Published
2024

8. MR Imaging of Adverse Effects and Ocular Growth Decline after Selective Intra-Arterial Chemotherapy for Retinoblastoma

Author

de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Göricke, Sophia, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Bot, Joseph C J, Munier, Francis L; https://orcid.org/0000-0002-8928-1050, Beck-Popovic, Maja; https://orcid.org/0000-0001-9502-5697, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Koob, Mériam, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Haan, Joeka; https://orcid.org/0009-0008-3050-6703, Göricke, Sophia, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, Bot, Joseph C J, Munier, Francis L; https://orcid.org/0000-0002-8928-1050, Beck-Popovic, Maja; https://orcid.org/0000-0001-9502-5697, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Koob, Mériam, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, and de Graaf, Pim; https://orcid.org/0000-0003-1938-0747

Abstract

This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment. Eyes were categorized into three groups: eyes receiving SIAC (Rb-SIAC), eyes treated with other eye-saving methods (Rb-control), and healthy eyes. The most prevalent adverse effects post-SIAC were inflammatory and vascular features, with therapy-induced contrast enhancement observed in the intraorbital optic nerve segment in 6% of patients. Quantitative analysis revealed significant growth arrest in Rb-SIAC eyes, particularly when treatment commenced ≤ 12 months of age. Optic nerve atrophy was a significant complication in Rb-SIAC eyes. In conclusion, this study highlights the vascular and inflammatory adverse effects observed post-SIAC in retinoblastoma patients and demonstrates a negative impact on eye and optic nerve growth, particularly in children treated ≤ 12 months of age, providing crucial insights for clinical management and future research.

Published
2024

9. Transcatheter CT Hepatic Arteriography Compared with Conventional CT Fluoroscopy Guidance in Percutaneous Thermal Ablation to Treat Colorectal Liver Metastases: A Single-Center Comparative Analysis of 2 Historical Cohorts

Author

Puijk, Robbert S., Nieuwenhuizen, Sanne, van den Bemd, Bente A.T., Ruarus, Alette H., Geboers, Bart, Vroomen, Laurien G.P.H., Muglia, Riccardo, de Jong, Marcus C., de Vries, Jan J.J., Scheffer, Hester J., van den Tol, Petrousjka M.P., and Meijerink, Martijn R.

Published
2020
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10. Value of CT-Guided Percutaneous Irreversible Electroporation Added to FOLFIRINOX Chemotherapy in Locally Advanced Pancreatic Cancer: A Post Hoc Comparison

Author

van Veldhuisen, Eran, Vroomen, Laurien G., Ruarus, Alette H., Derksen, Tyche C., Busch, Olivier R., de Jong, Marcus C., Kazemier, Geert, Puijk, Robbert S., Sorgedrager, Natasha S., Vogel, Jantien A., Scheffer, Hester J., van Lienden, Krijn P., Wilmink, Johanna W., Besselink, Marc G., and Meijerink, Martijn R.

Published
2020
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11. Treatment evaluation by volumetric segmentation in pediatric optic pathway glioma: evaluation of the effect of bevacizumab on intra-tumor components

Author

Bennebroek, Carlien A., primary, Schouten, Christiaan R., additional, Montauban-van Swijndregt, Maartje C., additional, Saeed, Peerooz, additional, Porro, Giorgio L., additional, Pott, Jan W. R., additional, Dittrich, Anne T. M., additional, Oostenbrink, Rianne, additional, Schouten-van Meeteren, Antoinette Y., additional, de Jong, Marcus C., additional, and de Graaf, Pim, additional

Published
2023
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14. MR Imaging of Adverse Effects and Ocular Growth Decline after Selective Intra-Arterial Chemotherapy for Retinoblastoma.

Author

de Bloeme, Christiaan M., van Elst, Sabien, Galluzzi, Paolo, Jansen, Robin W., de Haan, Joeka, Göricke, Sophia, Moll, Annette C., Bot, Joseph C. J., Munier, Francis L., Beck-Popovic, Maja, Puccinelli, Francesco, Aerts, Isabelle, Hadjistilianou, Theodora, Sirin, Selma, Koob, Mériam, Brisse, Hervé J., Cardoen, Liesbeth, Maeder, Philippe, de Jong, Marcus C., and de Graaf, Pim

Subjects
OPTIC nerve diseases, VISION disorders, EYE, QUALITATIVE research, RESEARCH funding, DISEASE management, MAGNETIC resonance imaging, RETROSPECTIVE studies, QUANTITATIVE research, TREATMENT effectiveness, RETINOBLASTOMA, CANCER chemotherapy, RESEARCH, DEEP learning, COMPARATIVE studies, INFLAMMATION
Abstract

Simple Summary: This study investigates the adverse effects of selective intra-arterial chemotherapy (SIAC) on the eyes and optic nerves of retinoblastoma patients using magnetic resonance imaging (MRI). We aim to understand the post-SIAC changes in orbital and ocular structures and evaluate their impact on eye and optic nerve growth. Experienced radiologists analyzed MR images of retinoblastoma eyes treated with SIAC, comparing them to eyes treated with other eye-saving methods and healthy eyes. Results reveal common adverse effects like inflammation and vascular changes, along with significant ocular growth arrest and optic nerve atrophy in eyes treated with SIAC, especially in children treated ≤ 12 months of age. This study underscores the importance of careful consideration when utilizing SIAC, particularly in young patients, due to its potential negative effects on eye and optic nerve development. This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment. Eyes were categorized into three groups: eyes receiving SIAC (Rb-SIAC), eyes treated with other eye-saving methods (Rb-control), and healthy eyes. The most prevalent adverse effects post-SIAC were inflammatory and vascular features, with therapy-induced contrast enhancement observed in the intraorbital optic nerve segment in 6% of patients. Quantitative analysis revealed significant growth arrest in Rb-SIAC eyes, particularly when treatment commenced ≤ 12 months of age. Optic nerve atrophy was a significant complication in Rb-SIAC eyes. In conclusion, this study highlights the vascular and inflammatory adverse effects observed post-SIAC in retinoblastoma patients and demonstrates a negative impact on eye and optic nerve growth, particularly in children treated ≤ 12 months of age, providing crucial insights for clinical management and future research. [ABSTRACT FROM AUTHOR]

Published
2024
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15. The Prediction of Biological Features Using Magnetic Resonance Imaging in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Author

van der Hulst, Hedda J., primary, Jansen, Robin W., additional, Vens, Conchita, additional, Bos, Paula, additional, Schats, Winnie, additional, de Jong, Marcus C., additional, Martens, Roland M., additional, Bodalal, Zuhir, additional, Beets-Tan, Regina G. H., additional, van den Brekel, Michiel W. M., additional, de Graaf, Pim, additional, and Castelijns, Jonas A., additional

Published
2023
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16. Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts

Author

Puijk, Robbert S., Ziedses des Plantes, Valentijn, Nieuwenhuizen, Sanne, Ruarus, Alette H., Vroomen, Laurien G. P. H., de Jong, Marcus C., Geboers, Bart, Hoedemaker-Boon, Caroline J., Thöne-Passchier, Deirdre H., Gerçek, Ceylan C., de Vries, Jan J. J., van den Tol, Petrousjka M. P., Scheffer, Hester J., and Meijerink, Martijn R.

Published
2019
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18. MRI Features for Identifying MYCN-amplified RB1 Wild-type Retinoblastoma

Author

Jansen, Robin W., primary, de Bloeme, Christiaan M., additional, Cardoen, Liesbeth, additional, Göricke, Sophia, additional, van Elst, Sabien, additional, Jessen, Jaime Lyn, additional, Ramasubramanian, Aparna, additional, Skalet, Alison H., additional, Miller, Audra K., additional, Maeder, Philippe, additional, Uner, Ogul E., additional, Hubbard, G. Baker, additional, Grossniklaus, Hans, additional, Boldt, H. Culver, additional, Nichols, Kim E., additional, Brennan, Rachel C., additional, Sen, Saugata, additional, Sirin, Selma, additional, Brisse, Hervé J., additional, Galluzzi, Paolo, additional, Dommering, Charlotte J., additional, Castelijns, Jonas A., additional, van der Valk, Paul, additional, Boellaard, Ronald, additional, Dorsman, Josephine, additional, Moll, Annette C., additional, de Jong, Marcus C., additional, and de Graaf, Pim, additional

Published
2023
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22. Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study

Author

Jansen, Robin W, Roohollahi, Khashayar, Uner, Ogul E, de Jong, Yvonne, de Bloeme, Christiaan M, Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J, Cardoen, Liesbeth, Castelijns, Jonas A, van der Valk, Paul, Moll, Annette C, Grossniklaus, Hans, Hubbard, G Baker, de Jong, Marcus C, Dorsman, Josephine, de Graaf, Pim, Jansen, Robin W, Roohollahi, Khashayar, Uner, Ogul E, de Jong, Yvonne, de Bloeme, Christiaan M, Göricke, Sophia, Sirin, Selma, Maeder, Philippe, Galluzzi, Paolo, Brisse, Hervé J, Cardoen, Liesbeth, Castelijns, Jonas A, van der Valk, Paul, Moll, Annette C, Grossniklaus, Hans, Hubbard, G Baker, de Jong, Marcus C, Dorsman, Josephine, and de Graaf, Pim

Abstract

OBJECTIVES To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma. METHODS In this retrospective multicenter cohort study, retinoblastoma patients with gene expression data and MRI were included. MRI features (scored blinded for clinical data) and matched genome-wide gene expression data were used to perform radiogenomic analysis. Expression data from each center were first separately processed and analyzed. The end product normalized expression values from different sites were subsequently merged by their Z-score to permit cross-sites validation analysis. The MRI features were non-parametrically correlated with expression of photoreceptorness (radiogenomic analysis), a gene expression signature informing on disease progression. Outcomes were compared to outcomes in a previous described cohort. RESULTS Thirty-six retinoblastoma patients were included, 15 were female (42%), and mean age was 24 (SD 18) months. Similar to the prior evaluation, this validation study showed that low photoreceptorness gene expression was associated with advanced stage imaging features. Validated imaging features associated with low photoreceptorness were multifocality, a tumor encompassing the entire retina or entire globe, and a diffuse growth pattern (all p < 0.05). There were a number of radiogenomic associations that were also not validated. CONCLUSIONS A part of the radiogenomic associations could not be validated, underlining the importance of validation studies. Nevertheless, cross-center validation of imaging features associated with photoreceptorness gene expression highlighted the capability radiogenomics to non-invasively inform on molecular subtypes in retinoblastoma. CLINICAL RELEVANCE STATEMENT Radiogenomics may serve as a surrogate for molecular subtyping based on histopathology material in an era of eye-sparing retinoblastoma treatment strategies. KEY POINTS - Sin

Published
2023

23. MRI Features for Identifying MYCN-amplified RB1 Wild-type Retinoblastoma

Author

Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Castelijns, Jonas A, van der Valk, Paul, Boellaard, Ronald, Dorsman, Josephine, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, de Graaf, Pim; https://orcid.org/0000-0003-1938-0747, Jansen, Robin W; https://orcid.org/0000-0003-0347-1919, de Bloeme, Christiaan M; https://orcid.org/0000-0002-4901-0301, Cardoen, Liesbeth; https://orcid.org/0000-0001-7842-8638, Göricke, Sophia, van Elst, Sabien; https://orcid.org/0000-0003-2784-1988, Jessen, Jaime Lyn, Ramasubramanian, Aparna, Skalet, Alison H, Miller, Audra K; https://orcid.org/0000-0003-2774-6059, Maeder, Philippe; https://orcid.org/0000-0002-2875-4889, Uner, Ogul E; https://orcid.org/0000-0002-8730-6859, Hubbard, G Baker; https://orcid.org/0000-0001-5427-438X, Grossniklaus, Hans, Boldt, H Culver; https://orcid.org/0000-0002-7292-2093, Nichols, Kim E; https://orcid.org/0000-0002-5581-6555, Brennan, Rachel C; https://orcid.org/0000-0002-2090-4395, Sen, Saugata; https://orcid.org/0000-0002-0418-712X, Sirin, Selma; https://orcid.org/0000-0003-4555-0367, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Galluzzi, Paolo; https://orcid.org/0000-0002-7553-5064, Dommering, Charlotte J; https://orcid.org/0000-0001-5565-7526, Castelijns, Jonas A, van der Valk, Paul, Boellaard, Ronald, Dorsman, Josephine, Moll, Annette C; https://orcid.org/0000-0002-9313-8345, de Jong, Marcus C; https://orcid.org/0000-0002-8524-5108, and de Graaf, Pim; https://orcid.org/0000-0003-1938-0747

Abstract

Background MYCN-amplified RB1 wild-type (MYCN$^{A}$RB1$^{+/+}$) retinoblastoma is a rare but clinically important subtype of retinoblastoma due to its aggressive character and relative resistance to typical therapeutic approaches. Because biopsy is not indicated in retinoblastoma, specific MRI features might be valuable to identify children with this genetic subtype. Purpose To define the MRI phenotype of MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and evaluate the ability of qualitative MRI features to help identify this specific genetic subtype. Materials and Methods In this retrospective, multicenter, case-control study, MRI scans in children with MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and age-matched children with RB1$^{-/-}$ subtype retinoblastoma were included (case-control ratio, 1:4; scans acquired from June 2001 to February 2021; scans collected from May 2018 to October 2021). Patients with histopathologically confirmed unilateral retinoblastoma, genetic testing (RB1/MYCN status), and MRI scans were included. Associations between radiologist-scored imaging features and diagnosis were assessed with the Fisher exact test or Fisher-Freeman-Halton test, and Bonferroni-corrected P values were calculated. Results A total of 110 patients from 10 retinoblastoma referral centers were included: 22 children with MYCN$^{A}$RB1$^{+/+}$ retinoblastoma and 88 control children with RB1$^{-/-}$ retinoblastoma. Children in the MYCN$^{A}$RB1$^{+/+}$ group had a median age of 7.0 months (IQR, 5.0-9.0 months) (13 boys), while children in the RB1$^{-/-}$ group had a median age of 9.0 months (IQR, 4.6-13.4 months) (46 boys). MYCN$^{A}$RB1$^{+/+}$ retinoblastomas were typically peripherally located (in 10 of 17 children; specificity, 97%; P < .001) and exhibited plaque or pleomorphic shape (in 20 of 22 children; specificity, 51%; P = .011) with irregular margins (in 16 of 22 children; specificity, 70%; P = .008) and extensive retina folding with vitreous enclosure (specificity, 94%; P < .0

Published
2023

28. Magnetic Resonance Imaging Can Reliably Differentiate Optic Nerve Inflammation from Tumor Invasion in Retinoblastoma with Orbital Cellulitis

Author

Jansen, Robin W., primary, van der Heide, Sophie, additional, Cardoen, Liesbeth, additional, Sirin, Selma, additional, de Bloeme, Christiaan M., additional, Galluzzi, Paolo, additional, Göricke, Sophia, additional, Brisse, Hervé J., additional, Maeder, Philippe, additional, Sen, Saugata, additional, Biewald, Eva, additional, Castelijns, Jonas A., additional, Moll, Annette C., additional, van der Valk, Paul, additional, de Jong, Marcus C., additional, de Graaf, Pim, additional, and Jansen, Robin W., additional

Published
2022
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31. Colorectal liver metastases: surgery versus thermal ablation (COLLISION) – a phase III single-blind prospective randomized controlled trial

Author

Puijk, Robbert S., Ruarus, Alette H., Vroomen, Laurien G. P. H., van Tilborg, Aukje A. J. M., Scheffer, Hester J., Nielsen, Karin, de Jong, Marcus C., de Vries, Jan J. J., Zonderhuis, Babs M., Eker, Hasan H., Kazemier, Geert, Verheul, Henk, van der Meijs, Bram B., van Dam, Laura, Sorgedrager, Natasha, Coupé, Veerle M. H., van den Tol, Petrousjka M. P., Meijerink, Martijn R., and COLLISION Trial Group

Published
2018
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35. Magnetic Resonance Imaging Can Reliably Differentiate Optic Nerve Inflammation from Tumor Invasion in Retinoblastoma with Orbital Cellulitis

Author

Jansen, Robin W, van der Heide, Sophie, Cardoen, Liesbeth, Sirin, Selma, de Bloeme, Christiaan M, Galluzzi, Paolo, Göricke, Sophia, Brisse, Hervé J, Maeder, Philippe, Sen, Saugata, Biewald, Eva, Castelijns, Jonas A, Moll, Annette C, van der Valk, Paul, de Jong, Marcus C, de Graaf, Pim, European Retinoblastoma Imaging Collaboration, Jansen, Robin W, van der Heide, Sophie, Cardoen, Liesbeth, Sirin, Selma, de Bloeme, Christiaan M, Galluzzi, Paolo, Göricke, Sophia, Brisse, Hervé J, Maeder, Philippe, Sen, Saugata, Biewald, Eva, Castelijns, Jonas A, Moll, Annette C, van der Valk, Paul, de Jong, Marcus C, de Graaf, Pim, and European Retinoblastoma Imaging Collaboration

Abstract

PURPOSE To investigate the prevalence and magnetic resonance imaging (MRI) phenotype of retinoblastoma-associated orbital cellulitis. Additionally, this study aimed to identify postlaminar optic nerve enhancement (PLONE) patterns differentiating between inflammation and tumor invasion. DESIGN A monocenter cohort study assessed the prevalence of orbital cellulitis features on MRI in retinoblastoma patients. A multicenter case-control study compared MRI features of the retinoblastoma-associated orbital cellulitis cases with retinoblastoma controls. PARTICIPANTS A consecutive retinoblastoma patient cohort of 236 patients (311 eyes) was retrospectively investigated. Subsequently, 30 retinoblastoma cases with orbital cellulitis were compared with 30 matched retinoblastoma controls without cellulitis. METHODS In the cohort study, retinoblastoma MRI scans were scored on presence of inflammatory features. In the case-control study, MRI scans were scored on intraocular features and PLONE patterns. Postlaminar enhancement patterns were compared with histopathologic assessment of postlaminar tumor invasion. Interreader agreement was assessed, and exact tests with Bonferroni correction were adopted for statistical comparisons. MAIN OUTCOME MEASURES Prevalence of retinoblastoma-associated orbital cellulitis on MRI was calculated. Frequency of intraocular MRI features was compared between cases and controls. Sensitivity and specificity of postlaminar optic nerve patterns for detection of postlaminar tumor invasion were assessed. RESULTS The MRI prevalence of retinoblastoma-associated orbital cellulitis was 6.8% (16/236). Retinoblastoma with orbital cellulitis showed significantly more tumor necrosis, uveal abnormalities (inflammation, hemorrhage, and necrosis), lens luxation (all P < 0.001), and a larger eye size (P = 0.012). The inflammatory pattern of optic nerve enhancement (strong enhancement similar to adjacent choroid) was solely found in orbital cellulitis cases, of whi

Published
2022

36. Assessment of early-stage optic nerve invasion in retinoblastoma using high-resolution 1.5 Tesla MRI with surface coils: a multicentre, prospective accuracy study with histopathological correlation

Author

Brisse, Hervé J., de Graaf, Pim, Galluzzi, Paolo, Cosker, Kristel, Maeder, Philippe, Göricke, Sophia, Rodjan, Firazia, de Jong, Marcus C., Savignoni, Alexia, Aerts, Isabelle, Desjardins, Laurence, Moll, Annette C., Hadjistilianou, Theodora, Toti, Paolo, van der Valk, Paul, Castelijns, Jonas A., Sastre-Garau, Xavier, and on behalf of the European Retinoblastoma Imaging Collaboration (ERIC)

Published
2015
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41. Screening for pineal trilateral retinoblastoma revisited: a meta-analysis

Author

de Jong, Marcus C, Kors, Wijnanda A, Moll, Annette C, de Graaf, Pim, Castelijns, Jonas A, Jansen, Robin W, Gallie, Brenda, Soliman, Sameh E, Shaikh, Furqan, Dimaras, Helen, Kivelä, Tero T, HUS Head and Neck Center, Silmäklinikka, Department of Ophthalmology and Otorhinolaryngology, University of Helsinki, and Helsinki University Hospital Area

Subjects
endocrine system, AGED 0-5 YEARS, MRI-BASED ASSESSMENT, PINEALOBLASTOMA, screening, CHILDREN, lead time, eye diseases, retinoblastoma, period at risk, HIGH-DOSE CHEMOTHERAPY, GLAND, STEM-CELL RESCUE, trilateral retinoblastoma, INTRAARTERIAL, 3125 Otorhinolaryngology, ophthalmology, LARGE POPULATION, pineoblastoma, MRI
Abstract

TOPIC: To determine the age up to which children are at risk of trilateral retinoblastoma (TRb) developing, whether its onset is linked to the age at which intraocular retinoblastomas develop, and the lead time from a detectable pineal TRb to symptoms.CLINICAL RELEVANCE: Approximately 45% of patients with retinoblastoma-those with a germline RB1 pathogenic variant-are at risk of pineal TRb developing. Early detection and treatment are essential for survival. Current evidence is unclear regarding the usefulness of screening for pineal TRb and, if useful, the age up to which screening should be continued.METHODS: We conducted a study according to the Meta-analysis of Observational Studies in Epidemiology guidelines for reporting meta-analyses of observational studies. We searched PubMed and Embase between January 1, 1966, and February 27, 2019, for published literature. We considered articles reporting patients with TRb with survival and follow-up data. Inclusion of articles was performed separately and independently by 2 authors, and 2 authors also independently extracted the relevant data. They resolved discrepancies by consensus.RESULTS: One hundred thirty-eight patients with pineal TRb were included. Of 22 asymptomatic patients, 21 (95%) were diagnosed before the age of 40 months (median, 16 months; interquartile range, 9-29 months). Age at diagnosis of pineal TRb in patients diagnosed with retinoblastoma at 6 months or younger versus older than 6 months were comparable (P = 0.44), suggesting independence between the ages at diagnosis of intraocular retinoblastoma and pineal TRb. The laterality of intraocular retinoblastoma and its treatment were not associated with the age at which pineal TRb was diagnosed. The lead time from asymptomatic to symptomatic pineal TRb was approximately 1 year. By performing a screening magnetic resonance imaging scan every 6 months after the diagnosis of heritable retinoblastoma (median age, 6 months) until 36 months of age, at least 311 and 776 scans would be required to detect 1 case of asymptomatic pineal TRb and to save a single life, respectively.CONCLUSIONS: Patients with retinoblastoma are at risk of pineal TRb developing for a shorter period than previously assumed, and the age at diagnosis of pineal TRb is independent of the age at diagnosis of retinoblastoma. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) level of evidence for these conclusions remains low.

Published
2020

42. MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature

Author

Jansen, Robin W., primary, de Bloeme, Christiaan M., additional, Brisse, Hervé J., additional, Galluzzi, Paolo, additional, Cardoen, Liesbeth, additional, Göricke, Sophia, additional, Maeder, Philippe, additional, Cassoux, Nathalie, additional, Gauthier, Arnaud, additional, Schlueter, Sabrina, additional, Hadjistilianou, Theodora, additional, Munier, Francis L., additional, Castelijns, Jonas A., additional, van der Valk, Paul, additional, Moll, Annette C., additional, de Jong, Marcus C., additional, and de Graaf, Pim, additional

Published
2020
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43. Screening for Pineal Trilateral Retinoblastoma Revisited

Author

de Jong, Marcus C., primary, Kors, Wijnanda A., additional, Moll, Annette C., additional, de Graaf, Pim, additional, Castelijns, Jonas A., additional, Jansen, Robin W., additional, Gallie, Brenda, additional, Soliman, Sameh E., additional, Shaikh, Furqan, additional, Dimaras, Helen, additional, and Kivelä, Tero T., additional

Published
2020
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45. Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis.

Author

de Jong, Marcus C., Shaikh, Furqan, Gallie, Brenda, Kors, Wijnanda A., Jansen, Robin W., Dommering, Charlotte, de Graaf, Pim, Moll, Annette C., Dimaras, Helen, Shroff, Manohar, Kivelä, Tero T., and Soliman, Sameh E.

Subjects
*EARLY diagnosis, *RETINOBLASTOMA, *MEDICAL screening, *MAGNETIC resonance imaging
Abstract

Purpose: To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening. Methods: We updated the search (PubMed and Embase) for published literature as performed by our research group in 2014 and 2019. Trilateral retinoblastoma (TRb) patients were eligible for inclusion if identifiable as unique and the age at which TRb was diagnosed was available. The search yielded 97 new studies. Three new studies and eight new patients were included. Combined with 189 patients from the previous meta‐analysis, the database included 197 patients. The main outcome was the percentage of asynchronous TRb in patients diagnosed before and after preset age thresholds of 6 and 12 months of age at retinoblastoma diagnosis. Results: Seventy‐nine per cent of patients with pineoblastoma are diagnosed with retinoblastoma before the age of 12 months. However, baseline MRI screening at time of retinoblastoma diagnosis fails to detect the later diagnosed pineal TRb in 89% of patients. We modelled that an additional MRI performed at the age of 29 months picks up 53% of pineoblastomas in an asymptomatic phase. The detection rate increased to 72%, 87% and 92%, respectively, with 2, 3 and 4 additional MRIs. Conclusions: An MRI of the brain in heritable retinoblastoma before the age of 12 months misses most pineoblastomas, while retinoblastomas are diagnosed most often before the age of 12 months. Optimally timed additional MRI scans of the brain can increase the asymptomatic detection rate of pineoblastoma. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Author

Martens, Roland M, Noij, Daniel P, Koopman, Thomas, Zwezerijnen, Ben, Heymans, Martijn, de Jong, Marcus C, Hoekstra, Otto S, Vergeer, Marije R, de Bree, Remco, Leemans, C René, de Graaf, Pim, Boellaard, Ronald, Castelijns, Jonas A, Martens, Roland M, Noij, Daniel P, Koopman, Thomas, Zwezerijnen, Ben, Heymans, Martijn, de Jong, Marcus C, Hoekstra, Otto S, Vergeer, Marije R, de Bree, Remco, Leemans, C René, de Graaf, Pim, Boellaard, Ronald, and Castelijns, Jonas A

Published
2019

47. Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M, Noij, Daniel P, Koopman, Thomas, Zwezerijnen, Ben, Heymans, Martijn, de Jong, Marcus C, Hoekstra, Otto S, Vergeer, Marije R, de Bree, Remco, Leemans, C René, de Graaf, Pim, Boellaard, Ronald, Castelijns, Jonas A, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M, Noij, Daniel P, Koopman, Thomas, Zwezerijnen, Ben, Heymans, Martijn, de Jong, Marcus C, Hoekstra, Otto S, Vergeer, Marije R, de Bree, Remco, Leemans, C René, de Graaf, Pim, Boellaard, Ronald, and Castelijns, Jonas A

Published
2019

48. Functional imaging early during (chemo)radiotherapy for response prediction in head and neck squamous cell carcinoma; a systematic review

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M., Noij, Daniel P., Ali, Meedie, Koopman, Thomas, Marcus, J. Tim, Vergeer, Marije R., de Vet, Henrica, de Jong, Marcus C., Leemans, C. René, Hoekstra, Otto S., de Bree, Remco, de Graaf, Pim, Boellaard, Ronald, Castelijns, Jonas A., MS Hoofd-Hals Chirurgische Oncologie, Cancer, Martens, Roland M., Noij, Daniel P., Ali, Meedie, Koopman, Thomas, Marcus, J. Tim, Vergeer, Marije R., de Vet, Henrica, de Jong, Marcus C., Leemans, C. René, Hoekstra, Otto S., de Bree, Remco, de Graaf, Pim, Boellaard, Ronald, and Castelijns, Jonas A.

Published
2019

49. Diagnostic Accuracy of Intraocular Tumor Size Measured with MR Imaging in the Prediction of Postlaminar Optic Nerve Invasion and Massive Choroidal Invasion of Retinoblastoma

Author

De Jong, Marcus C., van der Meer, Fenna J. S., Goricke, Sophia L., Brisse, Herve J., Galluzzi, Paolo, Maeder, Philippe, Sirin, Selma, De Francesco, Sonia, Sastre-Garau, Xavier, Metz, Klaus A., Cerase, Alfonso, Noij, Daniel P., van der Valk, Paul, Moll, Annette C., Castelijns, Jonas A., de Graaf, Pim, Radiology and nuclear medicine, Cardio-thoracic surgery, Pathology, Ophthalmology, EMGO - Quality of care, and CCA - Imaging

Subjects
Male, Pathology, medicine.medical_specialty, Retinal Neoplasms, Enucleation, Medizin, Intraocular Retinoblastoma, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Medicine, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, Retrospective Studies, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Retinoblastoma, Choroid Neoplasms, Optic Nerve Neoplasms, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Confidence interval, 030221 ophthalmology & optometry, Optic nerve, Regression Analysis, Population study, Female, business, Nuclear medicine, Forecasting
Abstract

Purpose To assess the correlation of intraocular retinoblastoma tumor size measured with magnetic resonance (MR) imaging in the prediction of histopathologically determined metastatic risk factors (postlaminar optic nerve invasion and massive choroidal invasion). Materials and Methods The ethics committee approved this retrospective multicenter study with a waiver of informed consent. The study population included 370 consecutive patients with retinoblastoma (375 eyes) who underwent baseline MR imaging, followed by primary enucleation from 1993 through 2014. Tumor sizes (maximum diameter and volume) were measured independently by two observers and correlated with histopathologic risk factors. Receiver operating characteristic curves were used to analyze the diagnostic accuracy of tumor size, and areas under the curve were calculated. Logistic regression analysis was performed to evaluate potential confounders. Results Receiver operating characteristic analysis of volume and diameter, respectively, yielded areas under the curve of 0.77 (95% confidence interval [CI]: 0.70, 0.85; P < .0001) and 0.78 (95% CI: 0.71, 0.85; P < .0001) for postlaminar optic nerve invasion (n = 375) and 0.67 (95% CI: 0.57, 0.77; P = .0020) and 0.70 (95% CI: 0.59, 0.80; P = .0004) for massive choroidal tumor invasion (n = 219). For the detection of co-occurring massive choroidal invasion and postlaminar optic nerve invasion (n = 219), volume and diameter showed areas under the curve of 0.81 (95% CI: 0.70, 0.91; P = .0032) and 0.83 (95% CI: 0.73, 0.93; P = .0016), respectively. Conclusion Intraocular tumor size shows a strong association with postlaminar optic nerve invasion and a moderate association with massive choroidal invasion. These findings provide diagnostic accuracy measures at different size cutoff levels, which could potentially be useful in a clinical setting, especially within the scope of the increasing use of eye-salvage treatment strategies. (©) RSNA, 2015 Online supplemental material is available for this article.

Published
2016

50. 9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology

Author

de Jong, Marcus C., de Graaf, Pim, Pouwels, Petra J.W., Beenakker, Jan Willem, Jansen, Robin W., Geurts, Jeroen J.G., Moll, Annette C., Castelijns, Jonas A., van der Valk, Paul, van der Weerd, Louise, Radiology and Nuclear Medicine, ARD - Amsterdam Reproduction and Development, CCA - Imaging and biomarkers, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Reproduction & Development (AR&D), Anatomy and neurosciences, APH - Quality of Care, APH - Health Behaviors & Chronic Diseases, ACS - Diabetes & metabolism, Ophthalmology, and Pathology

Subjects
eye diseases
Abstract

Background: Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of mortality, but detailed information about tumor morphology and disease extent in retinoblastoma is important for treatment decision making. Purpose: To demonstrate ultrahigh-field MRI tumor morphology and tumor extent in retinoblastoma correlating with in and ex vivo images with histopathology. Study Type: Prospective case series. Population: Six retinoblastoma patients (median age 5.5 months, range 2–14) were prospectively included in this study. Median time between diagnosis and enucleation was 8 days (range 7–19). Field Strength/Sequence: In vivo pre-enucleation at 1.5T MRI with a circular surface coil. Ex vivo imaging (FLASH T1-weighted and RARE T2-weighted) was performed at field strengths of 9.4T and 17.6T. Assessment: After ex vivo imaging, the eyes were histopathologically analyzed and morphologically matched with MRI findings by three authors (two with respectively 14 and 4 years of experience in ocular MRI and one with 16 years of experience in ophthalmopathology). Results: Small submillimeter morphological aspects of intraocular retinoblastoma were successfully depicted with higher-resolution MRI and matched with histopathology images. With ex vivo MRI a small subretinal tumor seed (300 μm) adjacent to the choroid was morphologically matched with histopathology. Also, a characteristic geographical pattern of vital tumor tissue (400 μm) surrounding a central vessel interspersed with necrotic areas correlated with histopathology images. Tumor invasion into the optic nerve showed a higher signal intensity on T1-weighted higher-resolution MRI. Data Conclusion: Higher-resolution MRI allows for small morphological aspects of intraocular retinoblastoma and extraocular disease extent not visible on currently used clinical in vivo MRI to be depicted. Level of Evidence: 4. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;47:1487–1497.

Published
2018

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