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273 results on '"Zhao, Yuanli"'

6. Treatment of Intracranial Vertebral Artery Dissecting Aneurysms Using Pipeline Embolization Devices: A Multicenter Cohort Study

Author

Zhang, Ying, Zhang, Fujunhui, Turhon, Mirzat, Huang, Jiliang, Li, Mengxing, Peng, Qichen, Zheng, Zhaoxu, Liu, Jian, Zhang, Yisen, Liu, Jianmin, Zhang, Hongqi, Li, Tianxiao, Song, Donglei, Zhao, Yuanli, Aisha, Maimaitili, Wang, Yunyan, Feng, Wenfeng, Wang, Yang, Wan, Jieqing, Mao, Guohua, Shi, Huaizhang, and Guan, Sheng

Published
2023
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7. Recurrence of Cerebral Arteriovenous Malformation Following Complete Obliteration Through Endovascular Embolization

Author

Hao, Qiang, Zhang, Haibin, Han, Heze, Jin, Hengwei, Ma, Li, Li, Ruinan, Li, Zhipeng, Li, Anqi, Yuan, Kexin, Zhu, Qinghui, Wang, Ke, Li, Runting, Lin, Fa, Wang, Chengzhuo, Zhang, Yukun, Zhang, Hongwei, Zhao, Yang, Jin, Weitao, Gao, Dezhi, Guo, Geng, Yan, Debin, Pu, Jun, Kang, Shuai, Ye, Xun, Li, Youxiang, Sun, Shibin, Wang, Hao, Chen, Yu, Chen, Xiaolin, and Zhao, Yuanli

Published
2023
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9. Comparison of Long-Term Outcomes in Ruptured Diffuse Brain Arteriovenous Malformations Between Interventional Therapy and Conservative Management

Author

Lu, Changyu, Han, Heze, Ma, Li, Li, Ruinan, Li, Zhipeng, Zhang, Haibin, Yuan, Kexin, Zhang, Yukun, Li, Anqi, Wang, Ke, Zhao, Yang, Jin, Weitao, Gao, Dezhi, Jin, Hengwei, Meng, Xiangyu, Yan, Debin, Li, Runting, Lin, Fa, Hao, Qiang, Wang, Hao, Ye, Xun, Kang, Shuai, Pu, Jun, Shi, Zhiyong, Chao, Xiaofeng, Lin, Zhengfeng, Lu, Junlin, Li, Youxiang, Zhao, Yuanli, Sun, Shibin, Chen, Xiaolin, Chen, Weiwei, Chen, Yu, and Wang, Shuo

Published
2023
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17. A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score

Author

Li, Runting, Lin, Fa, Chen, Yu, Lu, Junlin, Han, Heze, Ma, Li, Zhao, Yahui, Yan, Debin, Li, Ruinan, Yang, Jun, He, Shihao, Li, Zhipeng, Zhang, Haibin, Yuan, Kexin, Wang, Ke, Hao, Qiang, Ye, Xun, Wang, Hao, Li, Hongliang, Zhang, Linlin, Shi, Guangzhi, Zhou, Jianxin, Zhao, Yang, Zhang, Yukun, Li, Youxiang, Wang, Shuo, Chen, Xiaolin, and Zhao, Yuanli

Published
2023
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24. The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis

Author

Li, Runting, Lin, Fa, Chen, Yu, Lu, Junlin, Yang, Jun, Han, Heze, Yuan, Kexin, Wang, Ke, Yan, Debin, Li, Ruinan, He, Shihao, Li, Zhipeng, Zhang, Haibin, Chen, Xiheng, Ma, Li, Zhao, Yahui, Hao, Qiang, Ye, Xun, Wang, Hao, Li, Hongliang, Zhang, Linlin, Shi, Guangzhi, Zhou, Jianxin, Li, Youxiang, Wang, Shuo, Chen, Xiaolin, and Zhao, Yuanli

Published
2022
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27. Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage

Author

Li, Runting, Lin, Fa, Chen, Yu, Lu, Junlin, Han, Heze, Ma, Li, Zhao, Yahui, Yan, Debin, Li, Ruinan, Yang, Jun, He, Shihao, Li, Zhipeng, Zhang, Haibin, Yuan, Kexin, Wang, Ke, Hao, Qiang, Ye, Xun, Wang, Hao, Li, Hongliang, Zhang, Linlin, Shi, Guangzhi, Zhou, Jianxin, Zhao, Yang, Zhang, Yukun, Li, Youxiang, Wang, Shuo, Chen, Xiaolin, and Zhao, Yuanli

Published
2022
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30. Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry

Author

Chen, Yu, Han, Heze, Ma, Li, Li, Ruinan, Li, Zhipeng, Yan, Debin, Zhang, Haibin, Yuan, Kexin, Wang, Ke, Zhao, Yang, Zhang, Yukun, Jin, Weitao, Li, Runting, Lin, Fa, Meng, Xiangyu, Hao, Qiang, Wang, Hao, Ye, Xun, Kang, Shuai, Jin, Hengwei, Li, Youxiang, Gao, Dezhi, Sun, Shibin, Liu, Ali, Wang, Shuo, Chen, Xiaolin, and Zhao, Yuanli

Published
2022
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31. Differential WNT4 expression among various subtypes of moyamoya disease results in alterations of microtubule stability.

Author

He, Shihao, Zhou, Zhenyu, Zhang, Junze, Wang, Yanru, Liu, Ziqi, Hao, Xiaokuan, Wang, Xilong, Ye, Xun, Zhao, Yuanli, and Wang, Rong

Subjects
GLYCOGEN synthase kinase, ADENOMATOUS polyposis coli, THORACIC aneurysms, INTRACELLULAR tracking, INTERNAL carotid artery, TAU proteins
Abstract

This article discusses the findings of a study on moyamoya disease (MMD), a condition characterized by the occlusion of the intracranial internal carotid artery and the formation of collateral vessels. The study focuses on the differential protein metabolism among different subtypes of MMD and the role of WNT4 (wingless‐type MMTV integration site family member 4) in causing cellular impairments by reducing microtubule stability. The researchers used proteomic profiling and in vitro experiments to identify the differences in protein metabolism and explore the potential mechanisms of haemorrhagic MMD. The study suggests that overexpression of WNT4 may lead to decreased stability of cellular microtubules, which could contribute to the rupture and hemorrhage of moyamoya vessels. These findings provide new insights into the biomarkers and mechanisms of haemorrhagic MMD. [Extracted from the article]

Published
2024
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38. The association between hemoglobin concentration and clinical outcomes after aneurysmal subarachnoid hemorrhage: Insights from the LongTEAM registry.

Author

Lin, Fa, Lu, Changyu, Li, Runting, Chen, Yu, Han, Heze, Zhao, Yuanli, Chen, Xiaolin, and Zhao, Jizong

Subjects
SUBARACHNOID hemorrhage, CEREBRAL vasospasm, VENOUS thrombosis, HEMOGLOBINS, PROPORTIONAL hazards models, TREATMENT effectiveness
Abstract

Objective: The aim of this study is to explore whether preoperative hemoglobin levels could serve as a prospective biomarker for early brain injury in patients with aneurysmal subarachnoid hemorrhage (aSAH). This investigation seeks to discern its association with postoperative complications and unfavorable clinical outcomes. Methods: We conducted a comprehensive analysis of data derived from the LongTeam registry, including patients with aSAH diagnosed between January 2015 and September 2021. These patients were stratified into three distinct groups based on their hemoglobin levels: anemic, standard, and elevated HGB. We employed logistic models featuring spline transformations to assess the relationship between HGB levels and in‐hospital complications. Furthermore, a multivariate Cox proportional hazard model was employed to estimate the impact of elevated hemoglobin levels on the hazard function, which was elucidated through Kaplan–Meier curves. Results: Our study comprised a total of 988 patients, among whom 115 (11.6%) presented preoperative anemia, and 63 (6.4%) exhibited elevated preoperative HGB levels. Following adjustments for potential confounding factors, no significant disparity in risk was evident between anemic patients and those with standard HGB levels. However, individuals with elevated HGB levels displayed a heightened incidence and an increased risk of developing deep vein thrombosis (DVT, odds ratio [OR] = 2.39, 95% confidence interval [CI] = 1.16–4.91, p = 0.018; hazard ratio [HR] = 2.05, 95% CI 1.08–3.92, p = 0.015). Aberrant HGB concentrations did not demonstrate an association with other clinical outcomes. Conclusion: Our findings emphasize that abnormal HGB levels show no association with adverse outcomes at the 90 days mark after accounting for clinical confounding factors in patients with aSAH. Simultaneously, the study illuminates the potential of HGB as an early indicator for identifying patients at a heightened risk of developing DVT. [ABSTRACT FROM AUTHOR]

Published
2024
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39. ITGA2 as a prognostic factor of glioma promotes GSCs invasion and EMT by activating STAT3 phosphorylation.

Author

Zhang, Jin, Li, Ruinan, Zhang, Haibin, Wang, Shanshan, and Zhao, Yuanli

Abstract

Glioma is the most common malignant brain tumor in adults with a high mortality and recurrence rate. Integrin alpha 2 (ITGA2) is involved in cell adhesion, stem cell regulation, angiogenesis and immune cell function. The role of ITGA2 in glioma malignant invasion remains unknown. The function and clinical relevance of ITGA2 were analysed by bioinformatics databases. The expression of ITGA2 in parent cells and GSCs was detected by flow cytometry and immunofluorescence double staining. The role of ITGA2 on the malignant phenotype of GSCs and epithelial–mesenchymal transition (EMT) was identified by stem cell function assays and Western blot. The effect of ITGA2 on glioma progression in vivo was determined by the intracranial orthotopic xenograft model. Immunohistochemistry, Spearman correlation and Kaplan–Meier were used to analyse the relationship of ITGA2 with clinical features and glioma prognosis. Biological analysis showed that ITGA2 might be related to cell invasion and migration. ITGA2, enriched in GSCs and co-expressed with SOX2, promoted the invasion and migration of GSCs by activating STAT3 phosphorylation and enhancing EMT. ITGA2 knockout suppressed the intracranial orthotopic xenograft growth and prolonged the survival of xenograft mice. In addition, the expression level of ITGA2 was significantly correlated to the grade of malignancy, N-cadherin and Ki67. High expression of ITGA2 indicated a worse prognosis of glioma patients. As a biomarker for the prediction of prognosis, ITGA2 promotes the malignant invasion of GSCs by activating STAT3 phosphorylation and enhancing EMT, leading to tumor recurrence and poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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