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1,155 results on '"Zhang, Baoshan"'

1. Sequential Design with Derived Win Statistics

Author

Zhang, Baoshan and Wu, Yuan

Subjects
Statistics - Methodology
Abstract

The Win Ratio has gained significant traction in cardiovascular trials as a novel method for analyzing composite endpoints (Pocock and others, 2012). Compared with conventional approaches based on time to the first event, the Win Ratio accommodates the varying priorities and types of outcomes among components, potentially offering greater statistical power by fully utilizing the information contained within each outcome. However, studies using Win Ratio have largely been confined to fixed design, limiting flexibility for early decisions, such as stopping for futility or efficacy. Our study proposes a sequential design framework incorporating multiple interim analyses based on Win Ratio or Net Benefit statistics. Moreover, we provide rigorous proof of the canonical joint distribution for sequential Win Ratio and Net Benefit statistics, and an algorithm for sample size determination is developed. We also provide results from a finite sample simulation study, which show that our proposed method controls Type I error maintains power level, and has a smaller average sample size than the fixed design. A real study of cardiovascular study is applied to illustrate the proposed method., Comment: 36 pages, 1 figure, 5 tables

Published
2024

3. Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

Author

Gorman, Jason, Cheung, Crystal Sao-Fong, Duan, Zhijian, Ou, Li, Wang, Maple, Chen, Xuejun, Cheng, Cheng, Biju, Andrea, Sun, Yaping, Wang, Pengfei, Yang, Yongping, Zhang, Baoshan, Boyington, Jeffrey C., Bylund, Tatsiana, Charaf, Sam, Chen, Steven J., Du, Haijuan, Henry, Amy R., Liu, Tracy, Sarfo, Edward K., Schramm, Chaim A., Shen, Chen-Hsiang, Stephens, Tyler, Teng, I-Ting, Todd, John-Paul, Tsybovsky, Yaroslav, Verardi, Raffaello, Wang, Danyi, Wang, Shuishu, Wang, Zhantong, Zheng, Cheng-Yan, Zhou, Tongqing, Douek, Daniel C., Mascola, John R., Ho, David D., Ho, Mitchell, and Kwong, Peter D.

Published
2024
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6. Research Progress on the Sources and Enrichment of Selenium and Selenium-Rich Dietary Resources

Author

SUN Nan, WANG Huina, ZHANG Wei, ZHANG Yuyao, ZHAO Yu, HE Bo, ZHANG Haisheng, ZHANG Baoshan

Subjects
selenium-rich foods, selenium cycling, edible mushrooms, physiological metabolism, Food processing and manufacture, TP368-456
Abstract

Selenium-rich foods serve the dual-function of providing nutrients and organic selenium. In the situation of selenium deficiency in the entire population, it is crucial to understand the sources of selenium and its circulation in the natural environment and biological systems. Current research on selenium-rich foods focuses mostly on chemical synthesis and bio-organic conversion, which is highly specialized and not suitable for horizontal comparison of different selenium-rich foods. There are few studies on the circulation of selenium and the selenium contents and health benefits of different selenium-rich foods. This article summarizes the sources, circulation and metabolism of selenium, the sources and forms of natural selenium in selenium-rich foods, and the selenium absorption and metabolism pathways in plants, animals, and microorganisms. Next, it reviews the current status of research on selenium-rich foods from various sources, and gives an outlook on the future of selenium-rich foods. This review may serve as a foundation for in-depth comparison of selenium-rich foods from various sources, and provide scientific guidance for the research and development of novel healthy selenium-rich foods.

Published
2024
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9. Cholesterol reduction by immunization with a PCSK9 mimic

Author

Zhang, Baoshan, Chuang, Gwo-Yu, Biju, Andrea, Biner, Daniel, Cheng, Jiaxuan, Wang, Yiran, Bao, Saran, Chao, Cara W., Lei, Haotian, Liu, Tracy, Nazzari, Alexandra F., Yang, Yongping, Zhou, Tongqing, Chen, Steven J., Chen, Xuejun, Kong, Wing-Pui, Ou, Li, Parchment, Danealle K., Sarfo, Edward K., SiMa, HaoMin, Todd, John-Paul, Wang, Shuishu, Woodward, Ruth A., Cheng, Cheng, Rawi, Reda, Mascola, John R., and Kwong, Peter D.

Published
2024
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11. Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

Author

Banach, Bailey B., Pletnev, Sergei, Olia, Adam S., Xu, Kai, Zhang, Baoshan, Rawi, Reda, Bylund, Tatsiana, Doria-Rose, Nicole A., Nguyen, Thuy Duong, Fahad, Ahmed S., Lee, Myungjin, Lin, Bob C., Liu, Tracy, Louder, Mark K., Madan, Bharat, McKee, Krisha, O’Dell, Sijy, Sastry, Mallika, Schön, Arne, Bui, Natalie, Shen, Chen-Hsiang, Wolfe, Jacy R., Chuang, Gwo-Yu, Mascola, John R., Kwong, Peter D., and DeKosky, Brandon J.

Published
2023
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12. Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Author

Liu, Cuiping, Wang, Lingshu, Merriam, Jonah S., Shi, Wei, Yang, Eun Sung, Zhang, Yi, Chen, Man, Kong, Wing-Pui, Cheng, Cheng, Tsybovsky, Yaroslav, Stephens, Tyler, Verardi, Raffaello, Leung, Kwanyee, Stein, Cody, Olia, Adam S., Harris, Darcy R., Choe, Misook, Zhang, Baoshan, Graham, Barney S., Kwong, Peter D., Koup, Richard A., Pegu, Amarendra, and Mascola, John R.

Published
2023
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13. Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles

Author

MacDonald, Nicholas J., Singh, Kavita, Reiter, Karine, Nguyen, Vu, Shimp, Jr., Richard, Gittis, Apostolos G., Chen, Beth, Burkhardt, Martin, Zhang, Baoshan, Wang, Zhixiong, Herrera, Raul, Moler, Mackenzie, Lee, Duck-Yeon, Orr-Gonzalez, Sachy, Herrod, Jessica, Lambert, Lynn E., Rausch, Kelly M., Muratova, Olga, Jones, David S., Wu, Yimin, Jin, Albert J., Garboczi, David N., Duffy, Patrick E., and Narum, David L.

Published
2023
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16. Self-affirmation training can relieve negative emotions by improving self-integrity among older adults

Author

Dang, Qingxiu, Wu, Jiayi, Bai, Ruibei, and Zhang, Baoshan

Subjects
Emotions -- Research, Aged -- Care and treatment -- Psychological aspects, Self-affirmation (Psychology) -- Training, Integrity -- Research, Psychological research, Psychology and mental health
Abstract

Negative emotions have been prevalent with older adults and negatively affect their physical and mental health. On the basis of self-affirmation theory, the present study explored a set of simple and effective time-saving early intervention programs for older adults whose negative emotions are in a normal and controllable range. We designed a three-week intervention program to boost self-integrity and relieve negative emotions in older adults. The self-affirmation intervention group (n = 88) and control group (n = 85) received three different experimental manipulations, respectively. Self-integrity, depression, anxiety, and loneliness were assessed before and after the intervention. Results showed that the self-affirmation intervention highly improved self-integrity and further relieved the negative emotions of older adults in the intervention group. Further mediation analyses indicated that self-integrity mediated the effect of self-affirmation intervention on negative emotions. These findings enrich the field of research on the relationship between self-integrity and negative emotions. They also have important practical implications for interventions aimed at mitigating negative emotions among older adults., Author(s): Qingxiu Dang [sup.1] , Jiayi Wu [sup.2] , Ruibei Bai [sup.3] , Baoshan Zhang [sup.1] Author Affiliations: (1) grid.412498.2, 0000 0004 1759 8395, School of Psychology, Shaanxi Normal University, [...]

Published
2023
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17. The effect of stereotype threat on females' spatial perspective taking and the mediating role of executive functions

Author

Lin, Yao, Zhang, Baoshan, Jin, Dou, Zhang, Heyating, and Dang, Junhua

Subjects
Stereotype threat -- Influence, Psychology and mental health
Abstract

Females are considered to be at a disadvantage in spatial perspective taking. In this study, we examined whether stereotype threat negatively affects females' spatial perspective-taking ability and executive functions. Then we explored which components of executive function play a mediating role in the effect of stereotype threat on females' spatial perspective-taking ability. We carried out two experiments. In Experiment 1, female participants in a stereotype threat condition or a control condition completed a spatial perspective-taking test. The results showed that females' spatial perspective-taking ability was reduced by stereotype threat. In Experiment 2, female participants were again assigned to a stereotype threat condition or a control condition; then they were asked to complete tasks measuring three executive functions (inhibition, shifting, and updating), following which they completed the spatial perspective-taking test. Experiment 2 found that stereotype threat decreased inhibition, updating, and spatial perspective-taking performance. The results also showed that only inhibition accounted for the effect of stereotype threat on spatial perspective taking. To sum up, the results from the current study shed new light on the relationship between stereotype threat and spatial perspective-taking ability and explained the relationship from a more detailed perspective., Author(s): Yao Lin [sup.1] , Baoshan Zhang [sup.1] , Dou Jin [sup.1] , Heyating Zhang [sup.1] , Junhua Dang [sup.2] Author Affiliations: (1) grid.412498.2, 0000 0004 1759 8395, School of [...]

Published
2023
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19. Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases

Author

Olia, Adam S., Cheng, Cheng, Zhou, Tongqing, Biju, Andrea, Harris, Darcy R., Changela, Anita, Duan, Hongying, Ivleva, Vera B., Kong, Wing-Pui, Ou, Li, Rawi, Reda, Tsybovsky, Yaroslav, Van Wazer, David J., Corrigan, Angela R., Gonelli, Christopher A., Lee, Myungjin, McKee, Krisha, Narpala, Sandeep, O’Dell, Sijy, Parchment, Danealle K., Stancofski, Erik-Stephane D., Stephens, Tyler, Tan, Ivy, Teng, I-Ting, Wang, Shuishu, Wei, Qing, Yang, Yongping, Yang, Zhengrong, Zhang, Baoshan, Novak, Jan, Renfrow, Matthew B., Doria-Rose, Nicole A., Koup, Richard A., McDermott, Adrian B., Gall, Jason G., Lei, Q. Paula, Mascola, John R., and Kwong, Peter D.

Published
2023
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21. Cryo-EM structures of prefusion SIV envelope trimer

Author

Gorman, Jason, Wang, Chunyan, Mason, Rosemarie D., Nazzari, Alexandra F., Welles, Hugh C., Zhou, Tongqing, Bess, Jr, Julian W., Bylund, Tatsiana, Lee, Myungjin, Tsybovsky, Yaroslav, Verardi, Raffaello, Wang, Shuishu, Yang, Yongping, Zhang, Baoshan, Rawi, Reda, Keele, Brandon F., Lifson, Jeffrey D., Liu, Jun, Roederer, Mario, and Kwong, Peter D.

Published
2022
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22. The Relationship between Math-Gender Stereotype and Academic Burnout: The Mediating Roles of the Performance-Avoidance Goal and Self-Handicapping

Author

Zhang, Heyating, Chen, Xin, Zhang, Baoshan, and Kelley, Grant W.

Abstract

In the current study, we examined the relationship between math-gender stereotypes, academic burnout, achievement goal orientation, and self-handicapping in Chinese adolescent students. The data came from 1170 participants (552 boys and 618 girls) from four secondary schools and was analyzed with structural equation models. The results showed that the math-gender stereotype was positively associated with academic burnout in the girls' group. Meanwhile, girls' endorsement of the math-gender stereotype was positively associated with academic burnout through the individual mediating effect of the performance-avoidance goal and that of self-handicapping. More importantly, the chain from performance-avoidance goal to self-handicapping also played a mediating role in the relationship between math-gender stereotypes and academic burnout among adolescent girls. However, in the boys' group, we did not find an obvious significant relationship between math-gender stereotypes and academic burnout. The results can contribute to the theoretical system of the motivational mechanism of academic burnout, and it may also have implications on the practice of alleviating negative effects of math-gender stereotypes on academic burnout through minimizing the tendency of performance-avoidance goals and self-handicapping.

Published
2021
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23. HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide

Author

Wang, Shuishu, Matassoli, Flavio, Zhang, Baoshan, Liu, Tracy, Shen, Chen-Hsiang, Bylund, Tatsiana, Johnston, Timothy, Henry, Amy R., Teng, I-Ting, Tripathi, Prabhanshu, Becker, Jordan E., Changela, Anita, Chaudhary, Ridhi, Cheng, Cheng, Gaudinski, Martin, Gorman, Jason, Harris, Darcy R., Lee, Myungjin, Morano, Nicholas C., Novik, Laura, O’Dell, Sijy, Olia, Adam S., Parchment, Danealle K., Rawi, Reda, Roberts-Torres, Jesmine, Stephens, Tyler, Tsybovsky, Yaroslav, Wang, Danyi, Van Wazer, David J., Zhou, Tongqing, Doria-Rose, Nicole A., Koup, Richard A., Shapiro, Lawrence, Douek, Daniel C., McDermott, Adrian B., and Kwong, Peter D.

Published
2023
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25. Vaccine elicitation and structural basis for antibody protection against alphaviruses

Author

Sutton, Matthew S., Pletnev, Sergei, Callahan, Victoria, Ko, Sungyoul, Tsybovsky, Yaroslav, Bylund, Tatsiana, Casner, Ryan G., Cerutti, Gabriele, Gardner, Christina L., Guirguis, Veronica, Verardi, Raffaello, Zhang, Baoshan, Ambrozak, David, Beddall, Margaret, Lei, Hong, Yang, Eun Sung, Liu, Tracy, Henry, Amy R., Rawi, Reda, Schön, Arne, Schramm, Chaim A., Shen, Chen-Hsiang, Shi, Wei, Stephens, Tyler, Yang, Yongping, Florez, Maria Burgos, Ledgerwood, Julie E., Burke, Crystal W., Shapiro, Lawrence, Fox, Julie M., Kwong, Peter D., and Roederer, Mario

Published
2023
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31. Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses

Author

Stewart-Jones, Guillaume B. E., Gorman, Jason, Ou, Li, Zhang, Baoshan, Joyce, M. Gordon, Yang, Lijuan, Cheng, Cheng, Chuang, Gwo-Yu, Foulds, Kathryn E., Kong, Wing-Pui, Olia, Adam S., Sastry, Mallika, Shen, Chen-Hsiang, Todd, John-Paul, Tsybovsky, Yaroslav, Verardi, Raffaello, Yang, Yongping, Collins, Peter L., Corti, Davide, Lanzavecchia, Antonio, Scorpio, Diana G., Mascola, John R., Buchholz, Ursula J., and Kwong, Peter D.

Published
2021

37. Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life

Author

Zhang, Baoshan, Gollapudi, Deepika, Gorman, Jason, O’Dell, Sijy, Damron, Leland F., McKee, Krisha, Asokan, Mangaiarkarasi, Yang, Eun Sung, Pegu, Amarendra, Lin, Bob C., Chao, Cara W., Chen, Xuejun, Gama, Lucio, Ivleva, Vera B., Law, William H., Liu, Cuiping, Louder, Mark K., Schmidt, Stephen D., Shen, Chen-Hsiang, Shi, Wei, Stein, Judith A., Seaman, Michael S., McDermott, Adrian B., Carlton, Kevin, Mascola, John R., Kwong, Peter D., Lei, Q. Paula, and Doria-Rose, Nicole A.

Published
2022
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38. Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency

Author

Cai, Cindy X., Doria-Rose, Nicole A., Schneck, Nicole A., Ivleva, Vera B., Tippett, Brad, Shadrick, William R., O’Connell, Sarah, Cooper, Jonathan W., Schneiderman, Zachary, Zhang, Baoshan, Gowetski, Daniel B., Blackstock, Daniel, Demirji, Jacob, Lin, Bob C., Gorman, Jason, Liu, Tracy, Li, Yile, McDermott, Adrian B., Kwong, Peter D., Carlton, Kevin, Gall, Jason G., and Lei, Q. Paula

Published
2022
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39. Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody

Author

Madan, Bharat, Zhang, Baoshan, Xu, Kai, Chao, Cara W., O’Dell, Sijy, Wolfe, Jacy R., Chuang, Gwo-Yu, Fahad, Ahmed S., Geng, Hui, Kong, Rui, Louder, Mark K., Nguyen, Thuy Duong, Rawi, Reda, Schön, Arne, Sheng, Zizhang, Nimrania, Rajani, Wang, Yiran, Zhou, Tongqing, Lin, Bob C., Doria-Rose, Nicole A., Shapiro, Lawrence, Kwong, Peter D., and DeKosky, Brandon J.

Published
2021

49. Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

Author

Cottrell, Christopher A., Manne, Kartik, Kong, Rui, Wang, Shuishu, Zhou, Tongqing, Chuang, Gwo-Yu, Edwards, Robert J., Henderson, Rory, Janowska, Katarzyna, Kopp, Megan, Lin, Bob C., Louder, Mark K., Olia, Adam S., Rawi, Reda, Shen, Chen-Hsiang, Taft, Justin D., Torres, Jonathan L., Wu, Nelson R., Zhang, Baoshan, Doria-Rose, Nicole A., Cohen, Myron S., Haynes, Barton F., Shapiro, Lawrence, Ward, Andrew B., Acharya, Priyamvada, Mascola, John R., and Kwong, Peter D.

Published
2021
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