Search

Annotations enrich text corpora and provide necessary labels for natural language processing studies. To reason and infer underlying implicit knowledge captured by labels, an ontology is needed to provide a semantically annotated corpus with structured domain knowledge. Utilizing a corpus of adverse event documents annotated for sepsis-related signs and symptoms as a use case, this paper details how a terminology and corresponding ontology were developed. The Annotated Adverse Event NOte TErminology (AAENOTE) represents annotated documents and assists annotators in annotating text. In contrast, the complementary Catheter Infection Indications Ontology (CIIO) is intended for clinician use and captures domain knowledge needed to reason and infer implicit information from data. The approach taken makes ontology development understandable and accessible to domain experts without formal ontology training.

Figure S1. Derived allele frequency spectrum of macaque variants shared with the 1000Genomes Phase 3 dataset. The proportion of variants for each allele frequency is shown for the entire mGAP release 1.7 dataset (blue), and the subset of variants that intersect with sites reported in the 1000Genomes Phase 3 dataset (red). (PDF 69 kb)

Supplemental Methods. (DOCX 24 kb)

The distinction between primary and reactive thrombocytosis by bone marrow histology is very important. Reactive thrombocytosis, the most common cause of thrombocytosis, can be expected in postsplenectomy states; however, close hematological evaluation of prolonged thrombocytosis is essential to identify patients who may have an underlying myeloproliferative neoplasm. We report a 37-year-old woman who was found to have portal, mesenteric, and splenic vein thrombosis with thrombocytosis, two months after she had a splenectomy for spontaneous splenic rupture. Other reactive conditions and myeloproliferative neoplasms (MPN) were excluded, and subsequently, the diagnosis of triple-negative essential thrombocythemia (ET) was established by bone marrow histology. This case of primary thrombocythemia following splenectomy in a young patient illustrates some of the diagnostic difficulties associated with postsplenectomy thrombocytosis. Continuing reports of anecdotal experiences in managing similar complex scenarios is essential and remains the only reference for clinicians facing these rare conditions.

Date Presented 04/06/19 This study aims to investigate primary-school teachers' expectations of handwriting skills in primary-school children and explore differences in expectations between upper and lower primary-school children’s handwriting skills. Identification of handwriting components primary-school teachers view as important will allow OTs to better tailor interventions to ensure that handwriting concerns are adequately addressed. Primary Author and Speaker: Li Hui Ong Contributing Authors: Siok Khoon Soh, Shu-Jun Ho, May Yan Melissa Yeong

Venereal disease, now known as sexually-transmitted disease, has a long history of association with humanity. Syphilis, in particular, has attracted enormous debate and controversy ever since the fifteenth century when it erupted in epidemic form in Naples, Italy. This controversy continues not only because there are unresolved questions about where and when syphilis emerged (Powell and Cook 2005), but also because shifting attitudes, perceptions and values toward sexuality affect medical practice, social behaviour, public health practices and the experiences of people afflicted with it (Brandt 1987). This was certainly the case in early twentieth century Canada, the period within which this book is set. The shocking revelation in 1914 that the Canadian Expeditionary Force had the highest level of venereal disease of all the militaryunits serving in Europe was met with surprise, disgust and fear (Cassel 1987). At the time, venereal disease symbolized corrupt sexuality and was understood to be a sign of moral pollution, filth, and disordered sexual practice (Brandt 1987). How could such a disturbing situation have arisen in Canadian society? What did it signal about the state of morality, personal character, and the social order? Who was to blame for this hidden epidemic: irresponsible individuals or deplorable social conditions? What did the unexpectedly high prevalence of diseases transmitted through sexual behaviour mean for the future of the fledgling country? How could the damage wrought by venereal disease be prevented, controlled and cured? Damage Control takes up these questions and tells the untold story of how venereal disease, particularly syphilis, was experienced and understood in Hamilton, Ontario from World War I (WWI) to the mid-twentieth century. Written by fourth-year Honours Anthropology students studying infectious disease at McMaster University, this book is the product of a collaborative writing process. The authors brainstormed the subject matter of the book, then conducted in-depth research in archives in Hamilton and beyond to compile a rich set of newspapers, public health reports, images, and statistics which they shared through a university website. They made stimulating suggestions for each others’ chapters as the writing progressed from the germ of an idea to a fully-developed discussion. In short, everyone contributed to the entirety of the book in an exemplary demonstration of dedicated teamwork and commitment to the project.